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1. Preliminary Results and Research Perspectives on the Submerged Stone Age Sites in Storstrømmen, Denmark

Author

Fiedler Klara, Johansen Morten, and Binder Andreas G.

Subjects
submerged landscapes, southeast denmark, maritime archaeology, kongemose culture, mesolithic, Archaeology, CC1-960
Abstract

This article gives an overview of the survey campaigns and excavations undertaken within an area of the sound Storstrømmen in southeast Denmark from 2014 to 2017. Before the construction of a new bridge over the sound, geophysical data from the bridge corridor and other areas affected by the development project were used to give a representation of the moraine till as a proxy for the submerged prehistoric topography, with the topographical interpretation serving as a base for appointing areas with high potential for finding well-preserved Mesolithic sites. Several new Mesolithic sites were found during test excavations. The sites are preserved at different depths in the channel and range in date over the entire Danish Mesolithic period. All sites are located along former waterfronts, and the majority showed good preservation for organic material. Four of the discovered sites have been subject to excavations. The sites are located at different elevations and have between them the potential of contributing to the understanding of the human response to the dramatic topographic and environmental change that took place in Storstrømmen during the Atlantic period as a consequence of the rising sea level.

Published
2022
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2. Poster: Patient Community -- A Test Bed For Privacy Threat Analysis

Author

Kunz, Immanuel, Schneider, Angelika, Banse, Christian, Weiss, Konrad, and Binder, Andreas

Subjects
Computer Science - Cryptography and Security
Abstract

Research and development of privacy analysis tools currently suffers from a lack of test beds for evaluation and comparison of such tools. In this work, we propose a benchmark application that implements an extensive list of privacy weaknesses based on the LINDDUN methodology. It represents a social network for patients whose architecture has first been described in an example analysis conducted by one of the LINDDUN authors. We have implemented this architecture and extended it with more privacy threats to build a test bed that enables comprehensive and independent testing of analysis tools., Comment: 3 pages, 1 figure

Published
2023
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4. Application-Oriented Selection of Privacy Enhancing Technologies

Author

Kunz, Immanuel and Binder, Andreas

Subjects
Computer Science - Cryptography and Security
Abstract

To create privacy-friendly software designs, architects need comprehensive knowledge of existing privacy-enhancing technologies (PETs) and their properties. Existing works that systemize PETs, however, are outdated or focus on comparison criteria rather than providing guidance for their practical selection. In this short paper we present an enhanced classification of PETs that is more application-oriented than previous proposals. It integrates existing criteria like the privacy protection goal, and also considers practical criteria like the functional context, a technology's maturity, and its impact on various non-functional requirements. We expect that our classification simplifies the selection of PETs for experts and non-experts.

Published
2022
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6. Error Analysis of a Model Order Reduction Framework for Financial Risk Analysis

Author

Binder, Andreas, Jadhav, Onkar, and Mehrmann, Volker

Subjects
Mathematics - Numerical Analysis, Quantitative Finance - Computational Finance
Abstract

A parametric model order reduction (MOR) approach for simulating the high dimensional models arising in financial risk analysis is proposed on the basis of the proper orthogonal decomposition (POD) approach to generate small model approximations for the high dimensional parametric convection-diffusion reaction partial differential equations (PDE). The proposed technique uses an adaptive greedy sampling approach based on surrogate modeling to efficiently locate the most relevant training parameters, thus generating the optimal reduced basis. The best suitable reduced model is procured such that the total error is less than a user-defined tolerance. The three major errors considered are the discretization error associated with the full model obtained by discretizing the PDE, the model order reduction error, and the parameter sampling error. The developed technique is analyzed, implemented, and tested on industrial data of a puttable steepener under the two-factor Hull-White model. The results illustrate that the reduced model provides a significant speedup with excellent accuracy over a full model approach, demonstrating its potential applications in the historical or Monte Carlo value at risk calculations., Comment: 44 pages, 15 figures

Published
2021

9. Model order reduction for parametric high dimensional models in the analysis of financial risk

Author

Binder, Andreas, Jadhav, Onkar, and Mehrmann, Volker

Subjects
Quantitative Finance - Computational Finance, Mathematics - Numerical Analysis, 35L10, 65M06, 91G30, 91G60, 91G80
Abstract

This paper presents a model order reduction (MOR) approach for high dimensional problems in the analysis of financial risk. To understand the financial risks and possible outcomes, we have to perform several thousand simulations of the underlying product. These simulations are expensive and create a need for efficient computational performance. Thus, to tackle this problem, we establish a MOR approach based on a proper orthogonal decomposition (POD) method. The study involves the computations of high dimensional parametric convection-diffusion reaction partial differential equations (PDEs). POD requires to solve the high dimensional model at some parameter values to generate a reduced-order basis. We propose an adaptive greedy sampling technique based on surrogate modeling for the selection of the sample parameter set that is analyzed, implemented, and tested on the industrial data. The results obtained for the numerical example of a floater with cap and floor under the Hull-White model indicate that the MOR approach works well for short-rate models., Comment: 39 pages, 10 figures

Published
2020
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10. Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features

Author

Hopfner Franziska, Schormair Barbara, Knauf Franziska, Berthele Achim, Tölle Thomas R, Baron Ralf, Maier Christoph, Treede Rolf-Detlef, Binder Andreas, Sommer Claudia, Maihöfner Christian, Kunz Wolfram, Zimprich Friedrich, Heemann Uwe, Pfeufer Arne, Näbauer Michael, Kääb Stefan, Nowak Barbara, Gieger Christian, Lichtner Peter, Trenkwalder Claudia, Oexle Konrad, and Winkelmann Juliane

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Action myoclonus-renal failure syndrome is a hereditary form of progressive myoclonus epilepsy associated with renal failure. It is considered to be an autosomal-recessive disease related to loss-of-function mutations in SCARB2. We studied a German AMRF family, additionally showing signs of demyelinating polyneuropathy and dilated cardiomyopathy. To test the hypothesis whether isolated appearance of individual AMRF syndrome features could be related to heterozygote SCARB2 mutations, we screened for SCARB2 mutations in unrelated patients showing isolated AMRF features. Methods In the AMRF family all exons of SCARB2 were analyzed by Sanger sequencing. The mutation screening of unrelated patients with isolated AMRF features affected by either epilepsy (n = 103, progressive myoclonus epilepsy or generalized epilepsy), demyelinating polyneuropathy (n = 103), renal failure (n = 192) or dilated cardiomyopathy (n = 85) was performed as high resolution melting curve analysis of the SCARB2 exons. Results A novel homozygous 1 bp deletion (c.111delC) in SCARB2 was found by sequencing three affected homozygous siblings of the affected family. A heterozygous sister showed generalized seizures and reduction of nerve conduction velocity in her legs. No mutations were found in the epilepsy, renal failure or dilated cardiomyopathy samples. In the polyneuropathy sample two individuals with demyelinating disease were found to be carriers of a SCARB2 frameshift mutation (c.666delCCTTA). Conclusions Our findings indicate that demyelinating polyneuropathy and dilated cardiomyopathy are part of the action myoclonus-renal failure syndrome. Moreover, they raise the possibility that in rare cases heterozygous SCARB2 mutations may be associated with PNP features.

Published
2011
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11. Complexity Reduction for Parametric High Dimensional Models in the Analysis of Financial Risk

Author

Binder, Andreas, Jadhav, Onkar, Mehrmann, Volker, Bock, Hans Georg, Series Editor, de Hoog, Frank, Series Editor, Friedman, Avner, Series Editor, Gupta, Arvind, Series Editor, Nachbin, André, Series Editor, Ozawa, Tohru, Series Editor, Pulleyblank, William R., Series Editor, Rusten, Torgeir, Series Editor, Santosa, Fadil, Series Editor, Seo, Jin Keun, Series Editor, Tornberg, Anna-Karin, Series Editor, Ehrhardt, Matthias, editor, and Günther, Michael, editor

Published
2022
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12. Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial

Author

Beyersdorf, Friedhelm, Macharzina, Roland-Richard, Lechner, Gabriele, Menz, Carolin, Schonhardt, Sabine, Weinbeck, Michael, Greb, Olga, Otto, Dagmar, Winker, Thomas, Berger, Hermann, Poppert, Holger, Kühnl, Andreas, Pütz, Volker, Haase, Kathrin, Bodechtel, Ulf, Weiss, Norbert, Bergert, Hendrik, Meyne, Johannes, Groß, Justus, Kruse, Matthias, Gerdes, Berthold, Reinbold, Wolf-Dieter, Wuttig, Helge, Maier-Hasselmann, Andreas, Segerer, Manuela, Fuchs, Hans-Hermann, Gass, Sabine, Groden, Christoph, Niedergethmann, Marco, Griebe, Martin, Rosenkranz, Michael, Beck, Jürgen, Thomalla, Götz, Zeumer, Hermann H., Jauß, Marek, Kneist, Werner, Kneist, Martina, Staudacher, Thomas, Bernhard, Alfons, Jost, Petra, Prey, Nico, Knippschild, Jürgen, Kastrup, Oliver, Köhrmann, Martin, Frank, Benedikt, Bongers, Volkmar, Hoffmann, Johannes, Kniemeyer, Horst-Wilhelm, Knauth, Michael, Wasser, Kathrin, Stojanovic, Tomislav, Emmert, Hans, Tacke, Josef, Schwalbe, Bernhard, Nam, Eun-Mi, van Lengerich, Ulrike, Lowens, Stephan, Gröschel, Klaus, Uphaus, Timo, Gröschel, Sonja, Boor, Stephan, Dorweiler, Bernhard, Schmid, Elisabeth, Henkes, Hans, Hupp, Thomas, Singer, Oliver, Hamann, Gerhard, Wagner-Heck, Michaela, Kerth-Krick, Sibylle, Kilic, Metin, Huppert, Peter, Niederkorn, Kurt, Fruhwirth, Johannes, Klein, Günther, Pulkowski, Ulrich, Jöster, Karsten, Wacks, Jens-Henning, Kloppmann, Egbert, Vatankhah, Bijan, Hopf-Jensen, Silke, Stolze, Henning, Müller-Hülsbeck, Stefan, Walluscheck, Knut Peer, Schmitt, Hans-Michael, Grüger, Albert, Seemann, Jörg, Tilahun, Belay, Dichgans, Martin, Wollenweber, Frank Arne, Dörr, Angelika, Zollver, Adelgunde, Gäbel, Gabor, Hedtmann, Günter, Kollmar, Rainer, Claus, Detlef, Petermann, Christian, Kirsch, Stefanie, Bosnjak, Branko, Heiß, Johannes, Mühling, Holger, Wunderlich, Silke, Sabisch, Peter Nikolaus, Gahn, Georg, Storck, Martin, Arnold, Sebastian, Fischer, Urs, Gralla, Jan, von Mering, Matthias, Dißmann, Rüdiger, Kirsch, Delia, Schmidauer, Christoph, Waldenberger, Peter, Furtner, Martin, Kazarians, Haiko, Breuer, Peter, Arning, Christian, Rieper, Jürgen, Schmidt, Georg, Arnold, Marcel, Schroth, Gerhard, Weise, Jens, Zanow, Jürgen, Mayer, Thomas, Töpper, Rudolf, Gross-Fengels, Walter, Daum, Harald, Dittrich, Ralf, Ritter, Martin, Kasprzak, Bernd, Torsello, Giovanni, Pohlmann, Carsten, Brüning, Roland, Crispin, Alexander, Hofmann, Miriam, Müller, Thomas, Blessing, Erwin, Möhlenbruch, Markus, Ludwig, Ines, Amiri, Hemasse, Reiff, Tilman, Eckstein, Hans-Henning, Mansmann, Ulrich, Jansen, Olav, Fraedrich, Gustav, Mudra, Harald, Böckler, Dittmar, Böhm, Michael, Debus, E Sebastian, Fiehler, Jens, Mathias, Klaus, Ringelstein, Erich B, Schmidli, Jürg, Stingele, Robert, Zahn, Ralf, Zeller, Thomas, Niesen, Wolf-Dirk, Barlinn, Kristian, Binder, Andreas, Glahn, Jörg, Hacke, Werner, and Ringleb, Peter Arthur

Published
2022
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15. Numerical modeling of HTS excited medium‐speed wind generators with diode rectifier stator feeding.

Author

Köster, Robin and Binder, Andreas

Subjects
*STATORS, *ELECTRIC current rectifiers, *SUPERCONDUCTORS, *DIODES, *VOLTAGE, *MACHINERY
Abstract

Medium‐speed wind generators in the MW‐range with high‐temperature superconducting excitation winding are analyzed by means of non‐linear 2D and 3D FEM models. Besides an inverter‐based sinusoidal stator current feeding, a grid connection via a diode rectifier is analyzed by using coupled FEM and circuit simulations. The newly proposed modeling techniques are used to determine the excitation requirement for speed‐variable, unity power factor operation at constant stator voltage, as required for a diode rectifier feeding of the stator winding. 2D FEM models in the H‐A‐formulation are developed and used for the calculation of the hysteresis loss in the superconducting field winding at stationary operation as well as for an investigation of field current variations in the HTS field winding. The major modeling challenges consist in very long settling times of voltage‐fed models, several strong model non‐linearities and high requirements on the spatial discretization. Approaches for overcoming these difficulties with reasonable computational efficiency are proposed. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2)

Author

Beyersdorf, F, Grügerny, M, Macharzina, R-R, Lechner, G, Menz, C, Schonhardt, S, Weinbeck, M, Greb, O, Otto, D, Winker, T, Berger, H, Poppert, H, Pütz, V, Haase, K, Bodechtel, U, Weiss, N, Bergert, H, Meyne, J, Groß, J, Botsch, A, Kruse, M, Gerdes, B, Reinbold, WD, Wuttig, H, Maier-Hasselmann, A, Segerer, M, Fuchs, H-H, Gass, S, Schultz, H, Groden, C, Niedergethman, M, Griebe, M, Rosenkranz, M, Beck, C, Thomalla, G, Zeumer, H, Jauß, M, Kneist, W, Kneist, M, Staudacher, T, Bernhard, A, Jost, D, Prey, N, Knippschild, J, Kastrup, O, Köhrmann, M, Frank, B, Bongers, V, Hoffmann, J, Kniemeyer, H-W, Knauth, M, Wasser, K, Stojanovic, T, Emmert, H, Tacke, J, Schwalbe, B, Nam, E-M, van Lengerich, U, Lowens, S, Gröschel, K, Uphaus, T, Gröschel, S, Boor, S, Dorweiler, B, Schmid, E, Henkes, H, Hupp, T, Singer, O, Hamann, G, Wagner-Heck, M, Kerth-Krick, S, Kilic, M, Huppert, P, Niederkorn, K, Fruhwirth, J, Klein, G, Pulkowski, U, Jöster, K, Wacks, J-H, Kloppmann, E, Vatankhah, B, Hopf-Jensen, S, Stolze, H, Müller-Hülsbeck, S, Walluscheck, KP, Schmitt, H-M, Grüger, A, Seemann, J, Tilahun, B, Dichgans, M, Wollenweber, F, Dörr, A, Zollver, A, Gäbel, G, Hedtmann, G, Kollmar, R, Claus, D, Petermann, C, Kirsch, S, Bosnjak, B, Heiß, J, Mühling, H, Wunderlich, S, Sabisch, PN, Gahn, G, Storck, M, Arnold, S, Fischer, U, Gralla, J, von Mering, M, Dißmann, R, Kirsch, D, Schmidauer, C, Waldenberger, P, Furtner, M, Kazarians, H, Breuer, P, Arning, C, Rieper, J, Schmidt, G, Arnold, M, Schroth, G, Weise, J, Zanow, J, Mayer, T, Töpper, R, Gross-Fengels, W, Daum, H, Dittrich, R, Ritter, M, Kasprzak, B, Torsello, G, Pohlmann, C, Brüning, R, Amiri, H, Ludwig, I, Blessing, E, Möhlenbruch, M, Crispin, A, Hofman, M, Müller, T, Reiff, Tilman, Eckstein, Hans-Henning, Mansmann, Ulrich, Jansen, Olav, Fraedrich, Gustav, Mudra, Harald, Böckler, Dittmar, Böhm, Michael, Brückmann, Hartmut, Debus, E. Sebastian, Fiehler, Jens, Mathias, Klaus, Ringelstein, E. Bernd, Schmidli, Jürg, Stingele, Robert, Zahn, Ralf, Zeller, Thomas, Niesen, Wolf-Dirk, Barlinn, Kristian, Binder, Andreas, Glahn, Jörg, and Ringleb, Peter Arthur

Published
2021
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23. WLI, XPS and SEM/FIB/EDS Surface Characterization of an Electrically Fluted Bearing Raceway.

Author

Safdarzadeh, Omid, Farahi, Alireza, Binder, Andreas, Sezen, Hikmet, and Hofmann, Jan Philipp

Abstract

Electrical bearing currents may disturb the performance of the bearings via electro-corrosion if they surpass a limit of ca. 0.1 to 0.3 A/mm2. A continuous current flow, or, after a longer time span, an alternating current or a repeating impulse-like current, damages the raceway surface, leading in many cases to a fluting pattern on the raceway. Increased bearing vibration, audible noise, and decreased bearing lubrication as a result may demand a replacement of the bearings. Here, an electrically corroded axial ball bearing (type 51208) with fluting patterns is investigated. The bearing was lubricated with grease lubrication and was exposed to 4 A DC current flow. It is shown that the electric current flow causes higher concentrations of iron oxides and iron carbides on the bearing raceway surface together with increased surface roughness, leading to a mixed lubrication also at elevated bearing speeds up to 1500 rpm. The "electrically insulating" iron oxide layer and the "mechanically hard" iron carbide layer on the bearing steel are analysed by WLI, XPS, SEM, and EDS. White Light Interferometry (WLI) is used to provide an accurate measurement of the surface topography and roughness. X-ray Photoelectron Spectroscopy (XPS) measurements are conducted to analyze the chemical surface composition and oxidation states. Scanning Electron Microscopy (SEM) is applied for high-resolution imaging of the surface morphology, while the Focused Ion Beam (FIB) is used to cut a trench into the bearing surface to inspect the surface layers. With the Energy Dispersive X-ray spectrometry (EDS), the presence of composing elements is identified, determining their relative concentrations. The electrically-caused iron oxide and iron carbide may develop periodically along the raceway due to the perpendicular vibrations of the rolling ball on the raceway, leading gradually to the fluting pattern. Still, a simulation of this vibration-induced fluting-generation process from the start with the first surface craters—of the molten local contact spots—to the final fluting pattern is missing. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Neuropathischer Schmerz

Author

Binder, Andreas, Tomforde, Maike, Baron, Ralf, Baron, Ralf, editor, Koppert, Wolfgang, editor, Strumpf, Michael, editor, and Willweber-Strumpf, Anne, editor

Published
2019
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27. Effects of state-wide implementation of the Los Angeles Motor Scale for triage of stroke patients in clinical practice

Author

Behnke, Stefanie, Schlechtriemen, Thomas, Binder, Andreas, Bachhuber, Monika, Becker, Mark, Trauth, Benedikt, Lesmeister, Martin, Spüntrup, Elmar, Walter, Silke, Hoor, Lukas, Ragoschke-Schumm, Andreas, Merzou, Fatma, Tarantini, Luca, Bertsch, Thomas, Guldner, Jürgen, Magull-Seltenreich, Achim, Maier, Frank, Massing, Christoph, Fischer, Volkmar, Gawlitza, Michael, Donnevert, Katrin, Lamberty, Hans-Michael, Jung, Stefan, Strittmatter, Matthias, Tonner, Silke, Schuler, Johannes, Liszka, Robert, Wagenpfeil, Stefan, Grunwald, Iris Q., Reith, Wolfgang, and Fassbender, Klaus

Published
2021
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