Search

Your search keyword '"Bindra, Anivind Kaur"' showing total 21 results
Start Over Author "Bindra, Anivind Kaur"
21 results on '"Bindra, Anivind Kaur"'

6. Light‐Triggered Hypoxia‐Responsive Nanoscale Metal‐Organic Frameworks for Highly Efficient Antitumor Treatment.

Author

Yang, Guangbao, Bindra, Anivind Kaur, Phua, Soo Zeng Fiona, Liu, Jiawei, Wu, Hongwei, Wang, Dongdong, Qian, Cheng, Liu, Guofeng, and Zhao, Yanli

Subjects
*METAL-organic frameworks, *REACTIVE oxygen species, *TUMOR treatment, *PHOTODYNAMIC therapy, *SERUM albumin, *HYPOXEMIA
Abstract

Photodynamic therapy (PDT), as a noninvasive therapeutic tool, can result in a high level of hypoxia in tumors. Herein, hypoxia‐responsive nanoscale metal‐organic frameworks (UiO‐AZB) are prepared, which contain an azo group in its organic linker. After modifying the surface of UiO‐AZB with chlorin e6 (Ce6)‐conjugated human serum albumin (HSA), tirapazamine (TPZ) is employed as a hypoxia‐activated prodrug to be encapsulated into UiO‐AZB. The obtained nanosystem (UiO‐AZB/HC‐TPZ) can efficiently produce singlet oxygen under 660 nm light irradiation and cause severe hypoxia in tumors. This process in turn triggers the degradation of the frameworks and controllable release of activated TPZ for chemotherapy, finally leading to improved antitumor treatment through combinational PDT and hypoxia‐activated chemotherapy. This research demonstrates a distinctive treatment strategy, that is, using a simple stimulus (light irradiation) to trigger a series of activities (PDT, disintegration of UiO‐AZB structure, activation of TPZ, and controllable release) for realizing an effective treatment of tumors. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

8. Albumin-Based Therapeutics Capable of Glutathione Consumption and Hydrogen Peroxide Generation for Synergetic Chemodynamic and Chemotherapy of Cancer

Author

Yang, Guangbao, primary, Wang, Dongdong, additional, Phua, Soo Zeng Fiona, additional, Bindra, Anivind Kaur, additional, Qian, Cheng, additional, Zhang, Rui, additional, Cheng, Liang, additional, Liu, Guofeng, additional, Wu, Hongwei, additional, Liu, Zhuang, additional, and Zhao, Yanli, additional

Published
2022
Full Text
View/download PDF

9. A Plasmonic Supramolecular Nanohybrid as a Contrast Agent for Site‐Selective Computed Tomography Imaging of Tumor

Author

Bindra, Anivind Kaur, primary, Sreejith, Sivaramapanicker, additional, Prasad, Rajendra, additional, Gorain, Mahadeo, additional, Thomas, Rijil, additional, Jana, Deblin, additional, Nai, Mui Hoon, additional, Wang, Dongdong, additional, Tharayil, Abhimanyu, additional, Kundu, Gopal C., additional, Srivastava, Rohit, additional, Thomas, Sabu, additional, Lim, Chwee Teck, additional, and Zhao, Yanli, additional

Published
2021
Full Text
View/download PDF

16. A Plasmonic Supramolecular Nanohybrid as a Contrast Agent for Site‐Selective Computed Tomography Imaging of Tumor.

Author

Bindra, Anivind Kaur, Sreejith, Sivaramapanicker, Prasad, Rajendra, Gorain, Mahadeo, Thomas, Rijil, Jana, Deblin, Nai, Mui Hoon, Wang, Dongdong, Tharayil, Abhimanyu, Kundu, Gopal C., Srivastava, Rohit, Thomas, Sabu, Lim, Chwee Teck, and Zhao, Yanli

Subjects
*CONTRAST media, *COMPUTED tomography, *PLASMONICS, *GOLD nanoparticles, *PYRENE derivatives
Abstract

Design of organic–inorganic hybrids by anchoring of plasmonic materials such as gold nanoparticles (AuNPs) on self‐assembled organic substrates is useful but challenging. Herein, in situ anchoring of plasmonic nanoparticles on the surface of a designed spherical assembly via AuS bond formation is presented. First, a thiol tailed pyrene derivative (2) undergoes solvent dependent self‐assembly, transforming into an organic spherical aggregate (2agg). The thiol (‐SH) rich surface of the organic assembly allows cumulative anchoring of AuNPs on the surface to form an organic–inorganic hybrid (Au@2agg). Further coating of biocompatible polyethylene glycol (PEG) leads to the construction of the final multicomponent system (PEG‐Au@2agg) exhibiting morphological and spectroscopic features. The potential of PEG‐Au@2agg as a bioprobe and a contrast agent is investigated by X‐ray computed tomography (CT) experiments in vivo. High X‐ray attenuation of directly anchored AuNP clusters on the surface of this supramolecular nanohybrids enhances the X‐ray CT contrast and allows tracing of site‐selective accumulation in mouse 4T1 breast tumor. Thus, this approach of designing organic–inorganic nanohybrids paves the way for developing future intelligent multifunctional nanosystems capable of cancer detection and imaging. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results