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42 results on '"Binenbaum, Yoav"'

6. Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors.

Author

Adu-Berchie, Kwasi, Brockman, Joshua M., Liu, Yutong, To, Tania W., Zhang, David K. Y., Najibi, Alexander J., Binenbaum, Yoav, Stafford, Alexander, Dimitrakakis, Nikolaos, Sobral, Miguel C., Dellacherie, Maxence O., and Mooney, David J.

Subjects
T cells, T cell receptors, T-cell exhaustion, INTRAVENOUS injections, TUMOR antigens, IMMUNE recognition, INTRAVENOUS therapy
Abstract

Although adoptive T cell therapy provides the T cell pool needed for immediate tumor debulking, the infused T cells generally have a narrow repertoire for antigen recognition and limited ability for long-term protection. Here, we present a hydrogel that locally delivers adoptively transferred T cells to the tumor site while recruiting and activating host antigen-presenting cells with GMCSF or FLT3L and CpG, respectively. T cells alone loaded into these localized cell depots provided significantly better control of subcutaneous B16-F10 tumors than T cells delivered through direct peritumoral injection or intravenous infusion. T cell delivery combined with biomaterial-driven accumulation and activation of host immune cells prolonged the activation of the delivered T cells, minimized host T cell exhaustion, and enabled long-term tumor control. These findings highlight how this integrated approach provide both immediate tumor debulking and long-term protection against solid tumors, including against tumor antigen escape. Adoptive T cell therapy has shown remarkable promise for the treatment of haematological malignancies. Here, the authors show that a cryogel platform for the simultaneous delivery of autologous T cells and recruitment of local antigen-presenting cells promotes long-lasting responses against solid tumours in mice. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study

Author

Amit, Moran, Binenbaum, Yoav, Sharma, Kanika, Ramer, Naomi, Ramer, Ilana, Agbetoba, Abib, Glick, Joelle, Yang, Xinjie, Lei, Delin, Bjrndal, Kristine, Godballe, Christian, Mücke, Thomas, Wolff, Klaus-Dietrich, Fliss, Dan, Eckardt, André M., Copelli, Chiara, Sesenna, Enrico, Palmer, Frank, Ganly, Ian, Patel, Snehal, and Gil, Ziv

Published
2015
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12. International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck

Author

Amit, Moran, Binenbaum, Yoav, Trejo–Leider, Leonor, Sharma, Kanika, Ramer, Naomi, Ramer, Ilana, Agbetoba, Abib, Miles, Brett, Yang, Xinjie, Lei, Delin, Bjrndal, Kristine, Godballe, Christian, Mücke, Thomas, Wolff, Klaus-Dietrich, Eckardt, André M., Copelli, Chiara, Sesenna, Enrico, Palmer, Frank, Ganly, Ian, Patel, Snehal, and Gil, Ziv

Published
2015
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16. Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors

Author

Zinger, Assaf, primary, Koren, Lilach, additional, Adir, Omer, additional, Poley, Maria, additional, Alyan, Mohammed, additional, Yaari, Zvi, additional, Noor, Nadav, additional, Krinsky, Nitzan, additional, Simon, Assaf, additional, Gibori, Hadas, additional, Krayem, Majd, additional, Mumblat, Yelena, additional, Kasten, Shira, additional, Ofir, Sivan, additional, Fridman, Eran, additional, Milman, Neta, additional, Lübtow, Michael M., additional, Liba, Lior, additional, Shklover, Jeny, additional, Shainsky-Roitman, Janna, additional, Binenbaum, Yoav, additional, Hershkovitz, Dov, additional, Gil, Ziv, additional, Dvir, Tal, additional, Luxenhofer, Robert, additional, Satchi-Fainaro, Ronit, additional, and Schroeder, Avi, additional

Published
2019
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21. Advanced Cold Plasma Device for Cancer Treatment

Author

Slutsker, Yakov Z., primary, Ryzhkov, Michael, additional, Felsteiner, Joshua, additional, Krasik, Yakov. E., additional, Cohen, Jacob T., additional, Binenbaum, Yoav, additional, Shtrichman, Ronit, additional, and Gil, Ziv, additional

Published
2018
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22. Nomograms for predicting survival and recurrence in patients with adenoid cystic carcinoma. An international collaborative study

Author

Ganly, Ian, primary, Amit, Moran, additional, Kou, Lei, additional, Palmer, Frank L., additional, Migliacci, Jocelyn, additional, Katabi, Nora, additional, Yu, Changhong, additional, Kattan, Michael W., additional, Binenbaum, Yoav, additional, Sharma, Kanika, additional, Naomi, Ramer, additional, Abib, Agbetoba, additional, Miles, Brett, additional, Yang, Xinjie, additional, Lei, Delin, additional, Bjoerndal, Kristine, additional, Godballe, Christian, additional, Mücke, Thomas, additional, Wolff, Klaus-Dietrich, additional, Fliss, Dan, additional, Eckardt, André M., additional, Chiara, Copelli, additional, Sesenna, Enrico, additional, Ali, Safina, additional, Czerwonka, Lukas, additional, Goldstein, David P., additional, Gil, Ziv, additional, and Patel, Snehal G., additional

Published
2015
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23. Abstracts from the Fourteenth Rambam Research Day, December 7, 2017.

Author

Blazer, Shraga, Klein, Ehud, Dwolatzky, Tzvi, Smolin, Bella, Levi, Leon, Raz-Pasteur, Ayelet, Mashiach, Tatiana, King, Daniel, Ene, Hila, Robicsek, Odile, Karry, Rachel, Ben-Yehuda, Rotem, Yitzhaki, Ofer, Wiener, Ina, Ben-Shachar, Dorit, Fridman, Eran, Binenbaum, Yoav, Milman, Neta, Shlomi, Tomer, and Gil, Ziv

Subjects
MEDICAL care, MEDICAL ethics, CLINICS
Published
2018
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25. Trends in human papillomavirus-related oropharyngeal cancer in Israel

Author

Amit, Moran, primary, Ilana, Kaplan, additional, Avraham, Sharon Pelles, additional, Binenbaum, Yoav, additional, Bachar, Gideon, additional, Billan, Salem, additional, Zaarura, Suliman, additional, Czerninski, Rakefet, additional, Bar-Tov, Matan, additional, Maly, Alexander, additional, Akrish, Sharon, additional, and Gil, Ziv, additional

Published
2015
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31. International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck

Author

Amit, Moran, primary, Binenbaum, Yoav, additional, Trejo–Leider, Leonor, additional, Sharma, Kanika, additional, Ramer, Naomi, additional, Ramer, Ilana, additional, Agbetoba, Abib, additional, Miles, Brett, additional, Yang, Xinjie, additional, Lei, Delin, additional, Bjørndal, Kristine, additional, Godballe, Christian, additional, Mücke, Thomas, additional, Wolff, Klaus‐Dietrich, additional, Eckardt, André M., additional, Copelli, Chiara, additional, Sesenna, Enrico, additional, Palmer, Frank, additional, Ganly, Ian, additional, Patel, Snehal, additional, and Gil, Ziv, additional

Published
2014
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32. Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study

Author

Amit, Moran, primary, Binenbaum, Yoav, additional, Sharma, Kanika, additional, Ramer, Naomi, additional, Ramer, Ilana, additional, Agbetoba, Abib, additional, Glick, Joelle, additional, Yang, Xinjie, additional, Lei, Delin, additional, Bjørndal, Kristine, additional, Godballe, Christian, additional, Mücke, Thomas, additional, Wolff, Klaus-Dietrich, additional, Fliss, Dan, additional, Eckardt, André M., additional, Copelli, Chiara, additional, Sesenna, Enrico, additional, Palmer, Frank, additional, Ganly, Ian, additional, Patel, Snehal, additional, and Gil, Ziv, additional

Published
2014
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35. Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

Author

Amit, Moran, primary, Binenbaum, Yoav, primary, Sharma, Kanika, primary, Ramer, Naomi, primary, Ramer, Ilana, primary, Agbetoba, Abib, primary, Miles, Brett, primary, Yang, Xinjie, primary, Lei, Delin, primary, Bjoerndal, Kristine, primary, Godballe, Christian, primary, Mücke, Thomas, primary, Wolff, Klaus-Dietrich, primary, Fliss, Dan, primary, Eckardt, André, primary, Copelli, Chiara, primary, Sesenna, Enrico, primary, Palmer, Frank, primary, Patel, Snehal, primary, and Gil, Ziv, additional

Published
2014
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36. Analysis of Failure in Patients with Adenoid Cystic Carcinoma of the Head and Neck

Author

Amit, Moran, primary, Binenbaum, Yoav, additional, Sharma, Kanika, additional, Ramer, Naomi, additional, Ramer, Ilana, additional, Agbetoba, Abib, additional, Miles, Brett, additional, Xinjie, Yang, additional, Delin, Lei, additional, Bjoerndal, Kristine, additional, Godballe, Christian, additional, Mücke, Thomas, additional, Klaus-Dietrich, Wolff, additional, Fliss, Dan, additional, Eckardt, Andre, additional, and Copelli, Chiara, additional

Published
2014
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37. Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study

Author

Amit, Moran, primary, Binenbaum, Yoav, additional, Sharma, Kanika, additional, Ramer, Naomi, additional, Ramer, Ilana, additional, Agbetoba, Abib, additional, Miles, Brett, additional, Yang, Xinjie, additional, Lei, Delin, additional, Bjøerndal, Kristine, additional, Godballe, Christian, additional, Mücke, Thomas, additional, Wolff, Klaus-Dietrich, additional, Fliss, Dan, additional, Eckardt, André M., additional, Copelli, Chiara, additional, Sesenna, Enrico, additional, Palmer, Frank, additional, Patel, Snehal, additional, and Gil, Ziv, additional

Published
2013
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39. Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

Author

Amit, Moran, primary, Binenbaum, Yoav, primary, Sharma, Kanika, primary, Naomi, Ramer, primary, Ilana, Ramer, primary, Abib, Agbetoba, primary, Miles, Brett, primary, Yang, Xinjie, primary, Lei, Delin, primary, Kristine, Bjoerndal, primary, Christian, Godballe, primary, Thomas, Mücke, primary, Klaus-Dietrich, Wolff, primary, Fliss, Dan, primary, Eckardt, André, primary, Chiara, Copelli, primary, Sesenna, Enrico, primary, Frank, Palmer, primary, Patel, Snehal, primary, and Gil, Ziv, additional

Published
2013
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40. An Orthotopic Mouse Model of Laryngeal Squamous Cell Carcinoma.

Author

Cohen, Jacob T., Gil, Ziv, Binenbaum, Yoav, Na’ara, Shorook, and Amit, Moran

Subjects
HISTOLOGY methodology, ANALYSIS of variance, ANIMAL experimentation, BIOLOGICAL models, LARYNGEAL tumors, MICE, NONPARAMETRIC statistics, SQUAMOUS cell carcinoma, STATISTICS, KAPLAN-Meier estimator, MANN Whitney U Test
Abstract

The article focuses on the use of orthotopic mouse model to analyze the laryngeal squamous cell carcinoma. It mentions that the animals were monitored through direct laryngoscopy and ultrasound for the survival and growth of tumor. It offers information on the phenotype and malignant behavior that creates its natural biologic behavior as of laryngeal cancer patients.

Published
2015
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41. Subcutaneous biodegradable scaffolds for restimulating the antitumour activity of pre-administered CAR-T cells.

Author

Zhang DKY, Brockman JM, Adu-Berchie K, Liu Y, Binenbaum Y, de Lázaro I, Sobral MC, Tresa R, and Mooney DJ

Abstract

The efficacy of adoptive T-cell therapies based on chimaeric antigen receptors (CARs) is limited by the poor proliferation and persistence of the engineered T cells. Here we show that a subcutaneously injected biodegradable scaffold that facilitates the infiltration and egress of specific T-cell subpopulations, which forms a microenvironment mimicking features of physiological T-cell activation, enhances the antitumour activity of pre-administered CAR-T cells. CAR-T-cell expansion, differentiation and cytotoxicity were driven by the scaffold's incorporation of co-stimulatory bound ligands and soluble molecules, and depended on the types of co-stimulatory molecules and the context in which they were presented. In mice with aggressive lymphoma, a single, local injection of the scaffold following non-curative CAR-T-cell dosing led to more persistent memory-like T cells and extended animal survival. Injectable biomaterials with optimized ligand presentation may boost the therapeutic performance of CAR-T-cell therapies., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)

Published
2024
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