22 results on '"Bing-Yang Chen"'
Search Results
2. Effects of ulinastatin combined with thymopentin on cellular immunity, humoral immunity and stress response in severe pneumonia
- Author
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Yan Zhong, Bing-Yang Chen, and Wen-Hui Huang
- Subjects
Humoral immunity ,Stress response ,Severe pneumonia ,lcsh:R ,lcsh:Medicine ,Thymopentin ,Ulinastatin ,Cellular immunity - Abstract
Objective: To explore the effects of ulinastatin combined with thymopentin on cellular immunity, humoral immunity and stress response in severe pneumonia. Methods: A total of 102 cases of severe pneumonia treated in our hospital from February 2016 to November 2017 were collected as subjects and randomly divided into the control group (n=51) and the observation group (n=51), the two groups were treated with routine symptomatic treatment. The control group was treated with the ulinastatin on the basis of routine treatment, the observation group was treated with thymopentin on the basis of the control group. The changes of cellular immunity, humoral immunity, stress response and liver function in the two groups were compared. Results: Before treatment, there was no significant difference in the levels of CD4+, CD8+, CD4+/CD8+, IgA, IgM, IgG, SOD, MDA, T-AOC, AKP, TB and ALT between the two groups (P>0.05). After treatment, the two groups of CD4+ and CD4+ /CD8+ were significantly increased (P
- Published
- 2018
3. Sliding-Mode Control Augmented with Broad Learning System for Self-Balancing Inverse-Atlas Ball-Riding Robots with Uncertainties
- Author
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Feng-Chun Tai, Ching-Chih Tsai, and Bing-Yang Chen
- Subjects
Lyapunov stability ,0209 industrial biotechnology ,Computer science ,Inverse ,Mobile robot ,02 engineering and technology ,Sliding mode control ,020303 mechanical engineering & transports ,020901 industrial engineering & automation ,0203 mechanical engineering ,Control theory ,Stability theory ,Ball (bearing) ,Trajectory ,Robot - Abstract
The paper presents a novel sliding-mode control method augmented with broad learning system (BLS), or abbreviated as BLS-SMC, for trajectory tracking and station keeping of an uncertain Inverse-Atlas ball-riding robot (IASBRR) driven by three omnidirectional wheels. After brief description of the dynamic model of the robot with frictions and gravity, a BLS-SMC controller is proposed to accomplish robust self-balancing and trajectory tracking of the IASBRR in the presence of unknown frictions, mass variations and model uncertainties. The proposed BLS-SMC controller is proven asymptotically stable using Lyapunov stability theory and Barbalta’s lemma. Three comparative simulations and two experiments are conducted to show the effectiveness and merits of the proposed control method. The comparative results also indicate that the proposed controller is superior more efficient by comparing to an existing method.
- Published
- 2019
4. Synthesis and evaluation of new α-methylene-γ-lactone carbamates with NO production inhibitory effects in lipopolysaccharide-induced RAW 264.7 macrophages
- Author
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Wen-Hao Shao, Hu Yuan, Wei-Dong Zhang, Bing-Yang Chen, Ji Ye, Xiang-Rong Cheng, Wanlin Chang, Shan Lin, Hao Chen, and Qingyan Sun
- Subjects
Lipopolysaccharides ,Carbamate ,Lipopolysaccharide ,Stereochemistry ,medicine.medical_treatment ,Anti-Inflammatory Agents ,Chemistry Techniques, Synthetic ,Nitric Oxide ,Inhibitory postsynaptic potential ,Nitric oxide ,Lactones ,Mice ,chemistry.chemical_compound ,Drug Discovery ,medicine ,Animals ,Methylene ,Cytotoxicity ,IC50 ,Pharmacology ,chemistry.chemical_classification ,Macrophages ,Organic Chemistry ,General Medicine ,RAW 264.7 Cells ,chemistry ,Carbamates ,Lactone - Abstract
A series of new α-methylene-γ-lactone carbamates were synthesized by an asymmetric synthetic route. The activities on inhibiting nitric oxide (NO) release of these compounds were evaluated in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. The results indicated that most of the compounds except one exhibited potent NO inhibitory effect with IC50 value more than 2 μΜ. The cytotoxicities of these compounds were estimated via MTT assays. The results suggested that six compounds were accompanied by low cytotoxicity. The structure–activity relationships were also discussed. The S configuration of C3 on lactones ring would be more helpful to NO inhibitory effect.
- Published
- 2015
5. Research on Evaluation of Popularity of Lijiang Scenic Area Based on Microblog Data
- Author
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Jia-sheng Wang, Kun Yang, Bing-yang Chen, and Meng-zhu Sun
- Subjects
010504 meteorology & atmospheric sciences ,Microblogging ,business.industry ,Computer science ,Internet privacy ,0211 other engineering and technologies ,02 engineering and technology ,01 natural sciences ,Popularity ,World Wide Web ,Social media ,business ,021101 geological & geomatics engineering ,0105 earth and related environmental sciences - Published
- 2017
6. Chemical constituents from the aerial parts of Psammosilene tunicoides
- Author
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Wei-Dong Zhang, Lei Shan, Bing-Yang Chen, Bo Wen, Xin Yuan, Bo Li, Ka-Li Fu, Yun-Heng Shen, and Ji Ye
- Subjects
HCT116 Cell ,chemistry.chemical_classification ,Ethanol ,Stereochemistry ,Chemistry ,Glycoside ,Plant Science ,Biochemistry ,chemistry.chemical_compound ,Psammosilene tunicoides ,Cell culture ,Chemical constituents ,Organic chemistry ,No production ,Cytotoxicity ,Agronomy and Crop Science ,Biotechnology - Abstract
Investigation of the 80% ethanol extract of the aerial parts of Psammosilene tunicoide afforded two carboline alkaloids (1–2), a γ-pyrone derivative (3), two p-hydroxy cinamic acid derivatives (4–5), two glycosides (6–7) and six known compounds (8–13). Their structures were established on the basis of spectroscopic analysis (1D-, 2D-NMR, ESI-MS, and HR-ESI-MS). All these compounds were evaluated for cytotoxicity against SMML-7721, A549, HCT116, and MCF-7 cell lines, and for inhibitory activity against NO production in LPS-induced RAW264.7 macrophages. However, only compound 2 had weak cytotoxic activity against the HCT116 cell line at 20 μM, while the others are inactive against four human tumor cell lines and only show weak inhibition activity against NO production at 50 μM.
- Published
- 2014
7. Synthesis and structure–activity relationships of guaiane-type sesquiterpene lactone derivatives with respect to inhibiting NO production in lipopolysaccharide-induced RAW 264.7 macrophages
- Author
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Qingyan Sun, Chun-Ting Liu, Wei-Dong Zhang, Jiang-Yun Liu, Hu Yuan, Hao Chen, Wen-Hao Shao, Bing-Yang Chen, Kaijian Bi, and Zeng Zhao
- Subjects
Lipopolysaccharides ,Lipopolysaccharide ,Stereochemistry ,Chemistry Techniques, Synthetic ,Nitric Oxide ,Sesquiterpene lactone ,Cell Line ,Nitric oxide ,Lactones ,Mice ,Sesquiterpenes, Guaiane ,Structure-Activity Relationship ,chemistry.chemical_compound ,Drug Discovery ,Ic50 values ,Animals ,Structure–activity relationship ,Organic chemistry ,MTT assay ,No production ,Pharmacology ,chemistry.chemical_classification ,Macrophages ,Organic Chemistry ,General Medicine ,chemistry ,Yield (chemistry) - Abstract
A guaiane framework was scaffolded by photochemical rearrangement reactions using α-santonin 1 as a starting material. Then, using a series of reactions, we synthesized the guaiane-type sesquiterpene lactone 5 in high yield. The inhibitory activities of compound 5 and of a series of derivatives on nitric oxide (NO) release were evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Compounds 6g, 7h, 7i, 7k and 8g, exhibited significant inhibitory effects on NO production, with IC50 values of 14.8, 22.3, 18.3, 17.4 and 7.0 μM, respectively. Their cytotoxicities were also estimated using an MTT assay. The structure–activity relationships of these compounds were also discussed.
- Published
- 2014
8. Failure Mechanism for GaN-Based High-Voltage Light-Emitting Diodes
- Author
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C.S. Chang, Bing-Yang Chen, Shoou-Jinn Chang, Ching-Shing Shen, and Chun-Lung Tseng
- Subjects
Materials science ,business.industry ,Whiskers ,Metallurgy ,Wide-bandgap semiconductor ,chemistry.chemical_element ,Gallium nitride ,Electromigration ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,law.invention ,chemistry.chemical_compound ,chemistry ,Aluminium ,law ,Whisker ,Optoelectronics ,Electrical and Electronic Engineering ,business ,Diode ,Light-emitting diode - Abstract
We report a detailed reliability test study on GaN-based high-voltage light-emitting diodes. Under high temperature (i.e., 80°C) and high current injection (i.e., 100 mA) conditions, it was found that Al metal whiskers were formed from the sidewall of the Cr/Al/Ti/Pt/Au p-finger metal after 120-h burn-in test. It was also found that the whiskers became longer as we increased the burn-in time. Furthermore, it was found that the formation of Al whiskers is directly related to Al migration.
- Published
- 2014
9. Neomerane-type sesquiterpenoids from Valeriana officinalis var. latifolia
- Author
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Qing-Xin Liu, Wei-Dong Zhang, Bing-Yang Chen, Zhu-Zhen Han, Xianpeng Zu, Hui-Liang Li, Zhao-hui Yan, Jin-xin Wang, and Xian-Qing Hu
- Subjects
Valerianaceae ,chemistry.chemical_compound ,Valeriana officinalis ,biology ,chemistry ,Stereochemistry ,Organic Chemistry ,Drug Discovery ,Carbon skeleton ,Positive control ,Catechin ,biology.organism_classification ,Biochemistry - Abstract
Valeneomerins A–D, two new neomerane-type sesquiterpenoids and two new nor-sesquiterpenoids, were isolated from the roots of Valeriana officinalis var. latifolia. Among them, valeneomerin A (1) was identified as a sesquiterpenoid with an unprecedented 15,3-lactone loop while valeneomerin C (3) and valeneomerin D (4) were determined to be nor-sesquiterpenoids with a new 15-reductive neomerane-type carbon skeleton. Their structures were elucidated by detailed spectroscopic analysis and Cu Kα X-ray crystallography. Compounds 1, 2, and 4 exhibited significant neuroprotective effects against H2O2 induced oxidative stress in SH-SY5Y cells with viability of 49.8, 40.9, and 44.6% each at 50 μM, respectively, in contrast to positive control (catechin, 50 μM) with viability of 32.6%.
- Published
- 2014
10. Synthesis and biological evaluation of phenyl substituted polyoxygenated xanthone derivatives as anti-hepatoma agents
- Author
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Jian Kang, Run-Hui Liu, Hu Yuan, Zhi-Jun Zhu, Bing-Yang Chen, Qingyan Sun, Rongcai Yue, Xing Yuan, Ming Dai, and Wei-Dong Zhang
- Subjects
Carcinoma, Hepatocellular ,Stereochemistry ,Xanthones ,Antineoplastic Agents ,Apoptosis ,Xanthone Derivatives ,Structure-Activity Relationship ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Drug Discovery ,Xanthone ,Tumor Cells, Cultured ,medicine ,Humans ,Structure–activity relationship ,Cytotoxicity ,Cell Proliferation ,030304 developmental biology ,Pharmacology ,0303 health sciences ,Dose-Response Relationship, Drug ,Molecular Structure ,Chemistry ,Liver Neoplasms ,Organic Chemistry ,Hep G2 Cells ,General Medicine ,medicine.disease ,3. Good health ,Biochemistry ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Hepatic stellate cell ,Drug Screening Assays, Antitumor ,Selectivity - Abstract
A series of novel derivatives of phenyl substituted tetramethoxy xanthone were synthesized and evaluated for their in vitro cytotoxicity against human hepatocellular carcinoma (HCC) and non-tumor hepatic cells. Among these derivatives, compound 6 was more potent than positive control 5-fluorouracil (5-Fu) on QGY-7703 and SMMC-7721 cells with IC50 values of 6.27 μM, 7.50 μM and 15.56 μM, 14.55 μM, respectively. Furthermore, compounds 6, 14, 16, and 29 exhibited much better selectivity toward the normal hepatic cell line QSG-7701 than 5-Fu. Additionally, compound 6 significantly induced cell apoptosis in QGY-7703 cells. Our findings suggested that these phenylxanthone derivatives may hold promise as chemotherapeutic agents for the treatment of human HCC.
- Published
- 2013
11. Inhibitory effect of 4,4′-dihydroxy-α-truxillic acid derivatives on NO production in lipopolysaccharide-induced RAW 264.7 macrophages and exploration of structure–activity relationships
- Author
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Qing Yan Sun, Bing Yang Chen, Hui-Zi Jin, Weidong Zhang, Lei Shan, Shan Xiang Liu, and Hua Wu Zeng
- Subjects
Lipopolysaccharides ,Models, Molecular ,Lipopolysaccharide ,Stereochemistry ,Clinical Biochemistry ,Pharmaceutical Science ,Crystallography, X-Ray ,Nitric Oxide ,010402 general chemistry ,Inhibitory postsynaptic potential ,01 natural sciences ,Biochemistry ,Nitric oxide ,Mice ,Structure-Activity Relationship ,chemistry.chemical_compound ,Drug Discovery ,Animals ,Structure–activity relationship ,Cytotoxic T cell ,No production ,Cytotoxicity ,Molecular Biology ,Dose-Response Relationship, Drug ,Molecular Structure ,010405 organic chemistry ,Truxillic acid ,Macrophages ,Organic Chemistry ,3. Good health ,0104 chemical sciences ,chemistry ,Molecular Medicine ,Cyclobutanes - Abstract
The inhibitory activity of 4,4′-dihydroxy-α-truxillic acid and its derivatives (5-1a–5-35a) on nitric oxide (NO) release was evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Compounds 5-3a, 5-4a, 5-5a, 5-10a, 5-24a, 5-26a and 5-30a exhibited significant inhibitory effects on NO production, with IC50 values of 19.8, 21.1, 16.4, 17.5, 20.8, 22.6 and 17.6 μM, respectively. Their cytotoxicities were also estimated using a CCK-8 assay. Among them, compound 5-10a showed no cytotoxic effect on cells up to a concentration of 50 μM. The structure–activity relationships of the compounds are also discussed.
- Published
- 2013
12. Electromagnetic Bandgap Structure by Low Temperature Co-Fired Ceramics Technology
- Author
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Xin Feng Pang, Longtu Li, Hai Guo, Jun Wu, Xiao Qing Zhang, Bing Yang Chen, Bo Li, Jing Bo Sun, and Ji Zhou
- Subjects
Materials science ,Microscope ,business.industry ,Scanning electron microscope ,HFSS ,Band gap ,General Engineering ,Ultra-wideband ,law.invention ,High impedance ,law ,visual_art ,Electronic engineering ,visual_art.visual_art_medium ,Optoelectronics ,Ceramic ,business ,Photonic crystal - Abstract
A EBG(Electromagnetic Bandgap) structure was prepared based on the theory of the high impedance surface photonic crystal and the HFSS emulating results. The measurement result showed that the bandgap of the EBG structure was in the Ultra Wideband range. The designed structure was fabricated by a method of low temperature co-fired ceramics technology(LTCC) using ceramics as the matrix and silver as the coils. The micro-structure was analyzed by microscope and scanning electron microscope which showed that these two kinds of materials were well connected. A bandgap between 4GHz~5.5GHz was found by the Vector Network Analyzer which was accord to the emulation.
- Published
- 2011
13. InGaAsN Metal–Semiconductor–Metal Photodetectors with Transparent Indium Tin Oxide Schottky Contacts
- Author
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Ricky W. Chuang, Yan-Kuin Su, S. H. Hsu, Bing-Yang Chen, and Wei-Cheng Chen
- Subjects
Fabrication ,Materials science ,Physics and Astronomy (miscellaneous) ,business.industry ,General Engineering ,General Physics and Astronomy ,Schottky diode ,Photodetector ,Substrate (electronics) ,Indium tin oxide ,Optoelectronics ,Metalorganic vapour phase epitaxy ,business ,Layer (electronics) ,Dark current - Abstract
GaAs-based photodetectors (PDs) draw much attention owing to several advantages, such as low fabrication cost and the mature process techniques. However, fabricating them is a difficult task for the lack of suitable absorption materials that can be coherently grown on the GaAs substrate. In this report, we provide another approach to fabricate GaAs-based PDs, in which the novel InGaAsN alloy is used as the absorption layer. Three structures of planar PDs were demonstrated using transparent indium tin oxide (ITO) contacts. The dark current of PDs were suppressed by applying the SiO2 Schottky-barrier enhancement layer, but the rough interface between the SiO2 and InGaAsN layer limited the device characteristics. Depositing a thin layer of ITO between the SiO2 and InGaAsN layers greatly improved the interface quality and the photo current-to-dark current ratio was also increased from 17.7 to 45.29 under 0.5 V bias.
- Published
- 2007
14. Synthesis, cytotoxicity and inhibition of NO production of ivangustin enantiomer analogues
- Author
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Lei Shan, Wei-Dong Zhang, Bing Yang Chen, Xiang Yang Qin, Xiaoguang Lei, and Jian-Jun Fu
- Subjects
Stereochemistry ,Stereoisomerism ,Antineoplastic Agents ,Nitric Oxide ,chemistry.chemical_compound ,Lactones ,Mice ,Structure-Activity Relationship ,Drug Discovery ,Structure–activity relationship ,Animals ,Humans ,Cytotoxicity ,IC50 ,Cells, Cultured ,Cell Proliferation ,Pharmacology ,Dose-Response Relationship, Drug ,Molecular Structure ,Cell growth ,Chemistry ,Macrophages ,Organic Chemistry ,General Medicine ,Aldol condensation ,Enantiomer ,Drug Screening Assays, Antitumor ,Lead compound ,Heterocyclic Compounds, 3-Ring - Abstract
The eight novel ivangustin enantiomer analogues possessing α-methylene-γ-butyrolactone moiety have been synthesized using (4S6R, 4S6S)-4-tert-butyldimethylsilyloxy-6-methylcyclohex-2-en-1-one (1) as starting material. These transformations were mainly carried out by aldol condensation reaction and one-pot annelation procedure. The stereochemistry of these synthesized analogues was determined by NOE analysis. Their cytoxicity was evaluated against the human cancer cell lines HCT-116 (colon), HL-60 (leukemia), QGY-7701 (liver), SMMC-7721 (liver), A549 (lung), MCF-7 (breast). The results showed that these analogues were more selective against the cell lines HL-60 and QGY-7701. Analogue 17 exhibited potent cytotoxicity and high selectivity toward HL-60 cell line with IC50 value of 1.02 μM, which suggested that it might be a promising anti-cancer lead compound. The inhibitory activities against NO production and the cytotoxicities in RAW 264.7 macrophages were determined at the same time. All of the analogues significantly inhibited the NO production with IC50 value in the range of 3.44-6.99 μM. Analogues 17, 22, 23 and 7 showed higher cytotoxicities, indicated their inhibitory activities against NO production may be influenced by the cytotoxicities.
- Published
- 2015
15. Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway
- Author
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Xia Li, Na Gao, Rongcai Yue, Lei Shan, Hui-Zi Jin, Xing Yuan, Guo-Zhen Wu, Weiwei He, Wei-Dong Zhang, Jing Zhao, Bing-Yang Chen, and Hu Yuan
- Subjects
Cell signaling ,Cellular differentiation ,Glutamic Acid ,lcsh:Medicine ,Pharmacology ,Biology ,Proteomics ,Neuroprotection ,PC12 Cells ,Protein Interaction Mapping ,medicine ,Animals ,Extracellular Signal-Regulated MAP Kinases ,lcsh:Science ,Neurons ,Principal Component Analysis ,Multidisciplinary ,Gene Expression Profiling ,lcsh:R ,Neurotoxicity ,Cell Differentiation ,Molecular Sequence Annotation ,Saponins ,medicine.disease ,MAP Kinase Kinase Kinases ,Triterpenes ,High-Throughput Screening Assays ,Rats ,Blot ,Neuroprotective Agents ,Mechanism of action ,Biochemistry ,Gene Expression Regulation ,raf Kinases ,lcsh:Q ,medicine.symptom ,Signal transduction ,Research Article ,Signal Transduction - Abstract
Astragaloside IV (AGS-IV) is a main active ingredient of Astragalus membranaceus Bunge, a medicinal herb prescribed as an immunostimulant, hepatoprotective, antiperspirant, a diuretic or a tonic as documented in Chinese Materia Medica. In the present study, we employed a high-throughput comparative proteomic approach based on 2D-nano-LC-MS/MS to investigate the possible mechanism of action involved in the neuroprotective effect of AGS-IV against glutamate-induced neurotoxicity in PC12 cells. Differential proteins were identified, among which 13 proteins survived the stringent filter criteria and were further included for functional discussion. Two proteins (vimentin and Gap43) were randomly selected, and their expression levels were further confirmed by western blots analysis. The results matched well with those of proteomics. Furthermore, network analysis of protein-protein interactions (PPI) and pathways enrichment with AGS-IV associated proteins were carried out to illustrate its underlying molecular mechanism. Proteins associated with signal transduction, immune system, signaling molecules and interaction, and energy metabolism play important roles in neuroprotective effect of AGS-IV and Raf-MEK-ERK pathway was involved in the neuroprotective effect of AGS-IV against glutamate-induced neurotoxicity in PC12 cells. This study demonstrates that comparative proteomics based on shotgun approach is a valuable tool for molecular mechanism studies, since it allows the simultaneously evaluate the global proteins alterations.
- Published
- 2015
16. Research of the distribution of tourists’ attributes based on internet data: A case study of Kunming
- Author
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Bing-yang Chen, Kun Yang, and Jia-sheng Wang
- Subjects
050210 logistics & transportation ,Geography ,business.industry ,0502 economics and business ,05 social sciences ,Internet privacy ,0202 electrical engineering, electronic engineering, information engineering ,Distribution (economics) ,020207 software engineering ,Advertising ,The Internet ,02 engineering and technology ,business - Published
- 2017
17. Protective effects of (E)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeine against hydrogen peroxide-induced injury in PC12 cells
- Author
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Yongge Yang, Na Gao, Wanlin Chang, Xing Yuan, Lei Shan, Bing-Yang Chen, Weidong Zhang, Rongcai Yue, and Hua-Wu Zeng
- Subjects
Antioxidant ,Cell Survival ,medicine.medical_treatment ,Glutathione reductase ,Apoptosis ,medicine.disease_cause ,Protective Agents ,Biochemistry ,PC12 Cells ,Lipid peroxidation ,Superoxide dismutase ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Caffeine ,medicine ,Animals ,Viability assay ,biology ,Dose-Response Relationship, Drug ,Cytochrome c ,General Medicine ,Hydrogen Peroxide ,Rats ,Oxidative Stress ,chemistry ,biology.protein ,Reactive Oxygen Species ,Oxidative stress - Abstract
(E)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeine (HOEC), a naturally caffeic ester isolated from Incarvillea mairei, has been reported to possess anti-inflammatory activity by targeting 5-lipoxygenase. However, its other potential activities have yet to be explored. In this study, we measured antioxidant activity of HOEC using the DPPH free radical-scavenging assay. Then, we exposed rat pheochromocytoma (PC12) cells to hydrogen peroxide (H2O2)-induced damage and investigated the antioxidant activity of HOEC. Cell viability, lactate dehydrogenase (LDH) release, cellular morphology, Hoechst 33342 fluorescent staining, and apoptosis of the PC12 cells were assessed after treatment with 0.3-10 μM HOEC for 2 h and exposure to 600 μM H2O2. Additionally, glutathione reductase (GR), superoxide dismutase (SOD), lipid peroxidation malondialdehyde (MDA), and intracellular reactive oxygen species (ROS) accumulation were assayed after the PC12 cells were exposed to H2O2. To investigate mechanism, apoptosis-related protein were evaluated, including cleaved caspase 3/7, cleaved PARP, Bcl-2, Bcl-XL, and cytochrome c. The results showed that HOEC possessed potent antioxidant activity and pre-treatment with HOEC prior to H2O2 exposure significantly increased cell viability, reduced the release of LDH, ameliorated changes in cell morphology, and inhibited apoptosis. Further, HOEC did the following: reduced intracellular accumulation of ROS and MDA; rescued loss of SOD and GR activities; inhibited activated caspase-3 and caspase-7, cleaved PARP, and cytochrome c release; up-regulated the antiapoptosis-related protein Bcl-2 and Bcl-XL; and down-regulated the apoptosis-related proteins Bax and Bad. These findings suggested that HOEC may be a therapeutic agent for treating oxidative stress-derived neurodegenerative disorders.
- Published
- 2014
18. ChemInform Abstract: Neomerane-Type Sesquiterpenoids from Valeriana officinalis var. latifolia
- Author
-
Hui-Liang Li, Xianpeng Zu, Wei-Dong Zhang, Xian-Qing Hu, Zhao-hui Yan, Jin-xin Wang, Qing-Xin Liu, Zhu-Zhen Han, and Bing-Yang Chen
- Subjects
Terpene ,Valeriana officinalis ,Cell culture ,Apoptosis ,Stereochemistry ,Chemistry ,Neuroblastoma ,medicine ,General Medicine ,medicine.disease ,Neuroprotection - Abstract
Valeneomerins A-D [(I)-(III)] are isolated and screened for their neuroprotective activities on hydrogen peroxide-induced apoptosis in human neuroblastoma SH-SY5Y cell lines.
- Published
- 2014
19. Improvement of synthesis process of 2'-hydroxychalcones
- Author
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Xiu-lin Ji, Xiao-yan Wang, Yong-sheng Jin, Jia-tai Dou, Hang Yang, Fei Zhao, and Bing-yang Chen
- Subjects
Chemistry ,business.industry ,Scientific method ,General Medicine ,Process engineering ,business - Published
- 2010
20. Chemical constituents from the aerial parts of Psammosilene tunicoides.
- Author
-
Bo Wen, Xin Yuan, Wei-Dong Zhang, Bing-Yang Chen, Ka-Li Fu, Bo Li, Ji Ye, Lei Shan, and Yun-Heng Shen
- Abstract
Investigation of the 80% ethanol extract of the aerial parts of Psammosilene tunicoide afforded two carboline alkaloids (1-2), a γ-pyrone derivative (3), two p-hydroxy cinamic acid derivatives (4-5), two glycosides (6-7) and six known compounds (8-13). Their structures were established on the basis of spectroscopic analysis (1D-, 2D-NMR, ESI-MS, and HR-ESI-MS). All these compounds were evaluated for cytotoxicity against SMML-7721, A549, HCT116, and MCF-7 cell lines, and for inhibitory activity against NO production in LPS-induced RAW264.7 macrophages. However, only compound 2 had weak cytotoxic activity against the HCT116 cell line at 20 µM, while the others are inactive against four human tumor cell lines and only show weak inhibition activity against NO production at 50 µM. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
21. Synthesis and structure-activity relationships of guaiane-type sesquiterpene lactone derivatives with respect to inhibiting NO production in lipopolysaccharide-induced RAW 264.7 macrophages.
- Author
-
Hao Chen, Bing-Yang Chen, Chun-Ting Liu, Zeng Zhao, Wen-Hao Shao, Hu Yuan, Kai-Jian Bi, Jiang-Yun Liu, Qing-Yan Sun, and Wei-Dong Zhang
- Subjects
- *
STRUCTURE-activity relationship in pharmacology , *SESQUITERPENE lactones , *CHEMICAL derivatives , *LIPOPOLYSACCHARIDES , *MACROPHAGES , *REARRANGEMENTS (Chemistry) - Abstract
A guaiane framework was scaffolded by photochemical rearrangement reactions using α-santonin 1 as a starting material. Then, using a series of reactions, we synthesized the guaiane-type sesquiterpene lactone 5 in high yield. The inhibitory activities of compound 5 and of a series of derivatives on nitric oxide (NO) release were evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Compounds 6g, 7h, 7i, 7k and 8g, exhibited significant inhibitory effects on NO production, with IC50 values of 14.8, 22.3, 18.3, 17.4 and 7.0 µM, respectively. Their cytotoxicities were also estimated using an MTT assay. The structure-activity relationships of these compounds were also discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
22. Failure Mechanism for GaN-Based High-Voltage Light-Emitting Diodes.
- Author
-
Shoou-Jinn Chang, Chung-Ying Chang, Chun-Lung Tseng, Ching-Shing Shen, and Bing-Yang Chen
- Abstract
We report a detailed reliability test study on GaN-based high-voltage light-emitting diodes. Under high temperature (i.e., 80°C) and high current injection (i.e., 100 mA) conditions, it was found that Al metal whiskers were formed from the sidewall of the Cr/Al/Ti/Pt/Au p-finger metal after 120-h burn-in test. It was also found that the whiskers became longer as we increased the burn-in time. Furthermore, it was found that the formation of Al whiskers is directly related to Al migration. [ABSTRACT FROM PUBLISHER]
- Published
- 2014
- Full Text
- View/download PDF
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