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2. One-year pulmonary impairment after severe COVID-19: a prospective, multicenter follow-up study

Author

Faverio, Paola, Luppi, Fabrizio, Rebora, Paola, D’Andrea, Gabriele, Stainer, Anna, Busnelli, Sara, Catalano, Martina, Modafferi, Giuseppe, Franco, Giovanni, Monzani, Anna, Galimberti, Stefania, Scarpazza, Paolo, Oggionni, Elisa, Betti, Monia, Oggionni, Tiberio, De Giacomi, Federica, Bini, Francesco, Bodini, Bruno Dino, Parati, Mara, Bilucaglia, Luca, Ceruti, Paolo, Modina, Denise, Harari, Sergio, Caminati, Antonella, Intotero, Marcello, Sergio, Pietro, Monzillo, Giuseppe, Leati, Giovanni, Borghesi, Andrea, Zompatori, Maurizio, Corso, Rocco, Valsecchi, Maria Grazia, Bellani, Giacomo, Foti, Giuseppe, and Pesci, Alberto

Published
2022
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3. Sarcopenia in idiopathic pulmonary fibrosis: a prospective study exploring prevalence, associated factors and diagnostic approach

Author

Faverio, Paola, Fumagalli, Alessia, Conti, Sara, Madotto, Fabiana, Bini, Francesco, Harari, Sergio, Mondoni, Michele, Oggionni, Tiberio, Barisione, Emanuela, Ceruti, Paolo, Papetti, Maria Chiara, Bodini, Bruno Dino, Caminati, Antonella, Valentino, Angela, Centanni, Stefano, Lanzi, Paola, Della Zoppa, Matteo, Crotti, Silvia, Grosso, Marco, Sukkar, Samir Giuseppe, Modina, Denise, Andreoli, Marco, Nicali, Roberta, Suigo, Giulia, Busnelli, Sara, Paciocco, Giuseppe, Lettieri, Sara, Mantovani, Lorenzo Giovanni, Cesana, Giancarlo, Pesci, Alberto, and Luppi, Fabrizio

Published
2022
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5. Brief practical guidelines for biologic prescriptions in severe asthma. Expert opinion.

Author

Sposato, Bruno, Bini, Francesco, Menzella, Francesco, Tognella, Silvia, and Micheletto, Claudio

Abstract

This brief paper is intended to be a quick guide to prescribe biologics in severe asthma by following Global Initiative for Asthma (GINA) guidelines but also considering the author’s personal opinions. The paper starts with the identification of candidates for biologic therapy examining next the biological markers to be taken into account for the phenotyping of inflammation. Finally, it indicates the type of biologic to be chosen. This guide also points out the possible signals that can allow us to identify patients with severe asthma that would otherwise be ignored. Furthermore, it tries to give some directions on how to proceed in order to select the right biologic in the cases where the overlapping of different phenotypes can be found or in non-T2 asthma. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Short-term evolution of nutritional status in patients with idiopathic pulmonary fibrosis

Author

Franco, Giovanni, primary, Faverio, Paola, additional, Fumagalli, Alessia, additional, Conti, Sara, additional, Madotto, Fabiana, additional, Bini, Francesco, additional, Harari, Sergio, additional, Mondoni, Michele, additional, Oggioni, Tiberio, additional, Barisone, Emanuela, additional, Ceruti, Paolo, additional, Papetti, Maria Chiara, additional, Bodini, Bruno Dino, additional, Caminati, Antonella, additional, Valentino, Angela, additional, Centanni, Stefano, additional, Lanzi, Paola, additional, Della Zoppa, Matteo, additional, Crotti, Silvia, additional, Grosso, Marco, additional, Sukkar, Samir Giuseppe, additional, Modina, Denise, additional, Andreoli, Marco, additional, Nicali, Roberta, additional, Suigo, Giulia, additional, Busnelli, Sara, additional, Paciocco, Giuseppe, additional, Lettieri, Sara, additional, Mantovani, Lorenzo Giovanni, additional, Cesana, Giancarlo, additional, Pesci, Alberto, additional, and Luppi, Fabrizio, additional

Published
2023
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9. Short-term Evolution of Nutritional Status in Patients with Idiopathic Pulmonary Fibrosis

Author

Faverio, P, Fumagalli, A, Conti, S, Madotto, F, Bini, F, Harari, S, Mondoni, M, Oggionni, T, Barisione, E, Ceruti, P, Papetti, M, Bodini, B, Caminati, A, Valentino, A, Centanni, S, Lanzi, P, Della Zoppa, M, Crotti, S, Grosso, M, Sukkar, S, Modina, D, Andreoli, M, Nicali, R, Suigo, G, Busnelli, S, Paciocco, G, Lettieri, S, Mantovani, L, Cesana, G, Pesci, A, Luppi, F, Faverio, Paola, Fumagalli, Alessia, Conti, Sara, Madotto, Fabiana, Bini, Francesco, Harari, Sergio, Mondoni, Michele, Oggionni, Tiberio, Barisione, Emanuela, Ceruti, Paolo, Papetti, Maria Chiara, Bodini, Bruno Dino, Caminati, Antonella, Valentino, Angela, Centanni, Stefano, Lanzi, Paola, Della Zoppa, Matteo, Crotti, Silvia, Grosso, Marco, Sukkar, Samir Giuseppe, Modina, Denise, Andreoli, Marco, Nicali, Roberta, Suigo, Giulia, Busnelli, Sara, Paciocco, Giuseppe, Lettieri, Sara, Mantovani, Lorenzo Giovanni, Cesana, Giancarlo, Pesci, Alberto, Luppi, Fabrizio, Faverio, P, Fumagalli, A, Conti, S, Madotto, F, Bini, F, Harari, S, Mondoni, M, Oggionni, T, Barisione, E, Ceruti, P, Papetti, M, Bodini, B, Caminati, A, Valentino, A, Centanni, S, Lanzi, P, Della Zoppa, M, Crotti, S, Grosso, M, Sukkar, S, Modina, D, Andreoli, M, Nicali, R, Suigo, G, Busnelli, S, Paciocco, G, Lettieri, S, Mantovani, L, Cesana, G, Pesci, A, Luppi, F, Faverio, Paola, Fumagalli, Alessia, Conti, Sara, Madotto, Fabiana, Bini, Francesco, Harari, Sergio, Mondoni, Michele, Oggionni, Tiberio, Barisione, Emanuela, Ceruti, Paolo, Papetti, Maria Chiara, Bodini, Bruno Dino, Caminati, Antonella, Valentino, Angela, Centanni, Stefano, Lanzi, Paola, Della Zoppa, Matteo, Crotti, Silvia, Grosso, Marco, Sukkar, Samir Giuseppe, Modina, Denise, Andreoli, Marco, Nicali, Roberta, Suigo, Giulia, Busnelli, Sara, Paciocco, Giuseppe, Lettieri, Sara, Mantovani, Lorenzo Giovanni, Cesana, Giancarlo, Pesci, Alberto, and Luppi, Fabrizio

Published
2023

10. Short-term Evolution of Nutritional Status in Patients with Idiopathic Pulmonary Fibrosis

Author

Faverio, Paola, primary, Fumagalli, Alessia, additional, Conti, Sara, additional, Madotto, Fabiana, additional, Bini, Francesco, additional, Harari, Sergio, additional, Mondoni, Michele, additional, Oggionni, Tiberio, additional, Barisione, Emanuela, additional, Ceruti, Paolo, additional, Papetti, Maria Chiara, additional, Bodini, Bruno Dino, additional, Caminati, Antonella, additional, Valentino, Angela, additional, Centanni, Stefano, additional, Lanzi, Paola, additional, Della Zoppa, Matteo, additional, Crotti, Silvia, additional, Grosso, Marco, additional, Sukkar, Samir Giuseppe, additional, Modina, Denise, additional, Andreoli, Marco, additional, Nicali, Roberta, additional, Suigo, Giulia, additional, Busnelli, Sara, additional, Paciocco, Giuseppe, additional, Lettieri, Sara, additional, Mantovani, Lorenzo Giovanni, additional, Cesana, Giancarlo, additional, Pesci, Alberto, additional, and Luppi, Fabrizio, additional

Published
2023
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15. Sarcopenia in idiopathic pulmonary fibrosis: a prospective study exploring prevalence, associated factors and diagnostic approach

Author

Faverio, P, Fumagalli, A, Conti, S, Madotto, F, Bini, F, Harari, S, Mondoni, M, Oggionni, T, Barisione, E, Ceruti, P, Papetti, M, Bodini, B, Caminati, A, Valentino, A, Centanni, S, Lanzi, P, Della Zoppa, M, Crotti, S, Grosso, M, Sukkar, S, Modina, D, Andreoli, M, Nicali, R, Suigo, G, Busnelli, S, Paciocco, G, Lettieri, S, Mantovani, L, Cesana, G, Pesci, A, Luppi, F, Faverio, Paola, Fumagalli, Alessia, Conti, Sara, Madotto, Fabiana, Bini, Francesco, Harari, Sergio, Mondoni, Michele, Oggionni, Tiberio, Barisione, Emanuela, Ceruti, Paolo, Papetti, Maria Chiara, Bodini, Bruno Dino, Caminati, Antonella, Valentino, Angela, Centanni, Stefano, Lanzi, Paola, Della Zoppa, Matteo, Crotti, Silvia, Grosso, Marco, Sukkar, Samir Giuseppe, Modina, Denise, Andreoli, Marco, Nicali, Roberta, Suigo, Giulia, Busnelli, Sara, Paciocco, Giuseppe, Lettieri, Sara, Mantovani, Lorenzo Giovanni, Cesana, Giancarlo, Pesci, Alberto, Luppi, Fabrizio, Faverio, P, Fumagalli, A, Conti, S, Madotto, F, Bini, F, Harari, S, Mondoni, M, Oggionni, T, Barisione, E, Ceruti, P, Papetti, M, Bodini, B, Caminati, A, Valentino, A, Centanni, S, Lanzi, P, Della Zoppa, M, Crotti, S, Grosso, M, Sukkar, S, Modina, D, Andreoli, M, Nicali, R, Suigo, G, Busnelli, S, Paciocco, G, Lettieri, S, Mantovani, L, Cesana, G, Pesci, A, Luppi, F, Faverio, Paola, Fumagalli, Alessia, Conti, Sara, Madotto, Fabiana, Bini, Francesco, Harari, Sergio, Mondoni, Michele, Oggionni, Tiberio, Barisione, Emanuela, Ceruti, Paolo, Papetti, Maria Chiara, Bodini, Bruno Dino, Caminati, Antonella, Valentino, Angela, Centanni, Stefano, Lanzi, Paola, Della Zoppa, Matteo, Crotti, Silvia, Grosso, Marco, Sukkar, Samir Giuseppe, Modina, Denise, Andreoli, Marco, Nicali, Roberta, Suigo, Giulia, Busnelli, Sara, Paciocco, Giuseppe, Lettieri, Sara, Mantovani, Lorenzo Giovanni, Cesana, Giancarlo, Pesci, Alberto, and Luppi, Fabrizio

Abstract

Background: Sarcopenia gained importance in the evaluation of patients with chronic respiratory diseases, including idiopathic pulmonary fibrosis (IPF), since it may impact negatively on clinical outcomes. Aim: Aim of this study is to evaluate the prevalence and factors associated with sarcopenia, defined according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) 2019 definition, and to evaluate the prevalence of the single criteria that define the EWGSOP2 definition (muscle strength, muscle quantity and physical performance), in a cohort of consecutive patients with IPF prospectively followed up in 9 hospitals in Northern Italy between December 2018 and May 2021. Methods: Enrolled patients underwent an extensive pulmonary and nutritional assessment, including bioelectrical impedance analysis, dynamometry and 4-m gait speed test, both at IPF diagnosis and at 6-month follow-up. Results: Out of the 83 patients (81% males, mean age 72.5 years) with IPF at disease diagnosis enrolled in the study, 19 (22.9%) showed sarcopenia, including 2 (2.4%) with severe sarcopenia, 5 (6.0%) with confirmed sarcopenia and 12 (14.5%) with probable sarcopenia. Sarcopenia was associated with a significantly higher severity of the disease and sedentary lifestyle, while no differences were observed in regards to body mass index, history of weight loss and comorbidities between patients with and without sarcopenia. Out of the 64 patients without sarcopenia at baseline, 16 cases showed alteration of muscle quantity and/or physical performance. In the 51 patients with complete data at 6-month follow-up, there were no cases of severe sarcopenia, 1 case (2.0%) showed confirmed sarcopenia, while the prevalence of probable sarcopenia was 19.6% (10 cases). No differences in regards to antifibrotic treatment received and onset of gastrointestinal side effects were observed between patients with and without sarcopenia at follow-up. Conclusions: The prevalence of sarcopenia in p

Published
2022

16. One-year pulmonary impairment after severe COVID-19: a prospective, multicenter follow-up study

Author

Faverio, P, Luppi, F, Rebora, P, D'Andrea, G, Stainer, A, Busnelli, S, Catalano, M, Modafferi, G, Franco, G, Monzani, A, Galimberti, S, Scarpazza, P, Oggionni, E, Betti, M, Oggionni, T, De Giacomi, F, Bini, F, Bodini, B, Parati, M, Bilucaglia, L, Ceruti, P, Modina, D, Harari, S, Caminati, A, Intotero, M, Sergio, P, Monzillo, G, Leati, G, Borghesi, A, Zompatori, M, Corso, R, Valsecchi, M, Bellani, G, Foti, G, Pesci, A, Faverio, Paola, Luppi, Fabrizio, Rebora, Paola, D'Andrea, Gabriele, Stainer, Anna, Busnelli, Sara, Catalano, Martina, Modafferi, Giuseppe, Franco, Giovanni, Monzani, Anna, Galimberti, Stefania, Scarpazza, Paolo, Oggionni, Elisa, Betti, Monia, Oggionni, Tiberio, De Giacomi, Federica, Bini, Francesco, Bodini, Bruno Dino, Parati, Mara, Bilucaglia, Luca, Ceruti, Paolo, Modina, Denise, Harari, Sergio, Caminati, Antonella, Intotero, Marcello, Sergio, Pietro, Monzillo, Giuseppe, Leati, Giovanni, Borghesi, Andrea, Zompatori, Maurizio, Corso, Rocco, Valsecchi, Maria Grazia, Bellani, Giacomo, Foti, Giuseppe, Pesci, Alberto, Faverio, P, Luppi, F, Rebora, P, D'Andrea, G, Stainer, A, Busnelli, S, Catalano, M, Modafferi, G, Franco, G, Monzani, A, Galimberti, S, Scarpazza, P, Oggionni, E, Betti, M, Oggionni, T, De Giacomi, F, Bini, F, Bodini, B, Parati, M, Bilucaglia, L, Ceruti, P, Modina, D, Harari, S, Caminati, A, Intotero, M, Sergio, P, Monzillo, G, Leati, G, Borghesi, A, Zompatori, M, Corso, R, Valsecchi, M, Bellani, G, Foti, G, Pesci, A, Faverio, Paola, Luppi, Fabrizio, Rebora, Paola, D'Andrea, Gabriele, Stainer, Anna, Busnelli, Sara, Catalano, Martina, Modafferi, Giuseppe, Franco, Giovanni, Monzani, Anna, Galimberti, Stefania, Scarpazza, Paolo, Oggionni, Elisa, Betti, Monia, Oggionni, Tiberio, De Giacomi, Federica, Bini, Francesco, Bodini, Bruno Dino, Parati, Mara, Bilucaglia, Luca, Ceruti, Paolo, Modina, Denise, Harari, Sergio, Caminati, Antonella, Intotero, Marcello, Sergio, Pietro, Monzillo, Giuseppe, Leati, Giovanni, Borghesi, Andrea, Zompatori, Maurizio, Corso, Rocco, Valsecchi, Maria Grazia, Bellani, Giacomo, Foti, Giuseppe, and Pesci, Alberto

Abstract

Background: Long-term pulmonary sequelae following hospitalization for SARS-CoV-2 pneumonia is largely unclear. The aim of this study was to identify and characterise pulmonary sequelae caused by SARS-CoV-2 pneumonia at 12-month from discharge. Methods: In this multicentre, prospective, observational study, patients hospitalised for SARS-CoV-2 pneumonia and without prior diagnosis of structural lung diseases were stratified by maximum ventilatory support (“oxygen only”, “continuous positive airway pressure (CPAP)” and “invasive mechanical ventilation (IMV)”) and followed up at 12 months from discharge. Pulmonary function tests and diffusion capacity for carbon monoxide (DLCO), 6 min walking test, high resolution CT (HRCT) scan, and modified Medical Research Council (mMRC) dyspnea scale were collected. Results: Out of 287 patients hospitalized with SARS-CoV-2 pneumonia and followed up at 1 year, DLCO impairment, mainly of mild entity and improved with respect to the 6-month follow-up, was observed more frequently in the “oxygen only” and “IMV” group (53% and 49% of patients, respectively), compared to 29% in the “CPAP” group. Abnormalities at chest HRCT were found in 46%, 65% and 80% of cases in the “oxygen only”, “CPAP” and “IMV” group, respectively. Non-fibrotic interstitial lung abnormalities, in particular reticulations and ground-glass attenuation, were the main finding, while honeycombing was found only in 1% of cases. Older patients and those requiring IMV were at higher risk of developing radiological pulmonary sequelae. Dyspnea evaluated through mMRC scale was reported by 35% of patients with no differences between groups, compared to 29% at 6-month follow-up. Conclusion: DLCO alteration and non-fibrotic interstitial lung abnormalities are common after 1 year from hospitalization due to SARS-CoV-2 pneumonia, particularly in older patients requiring higher ventilatory support. Studies with longer follow-ups are needed.

Published
2022

17. Scritti scelti

Author

Carlo Bini, Francesco Domenico Guerrazzi

Published
2013

18. Diagnosis and management of patients with α1-antitrypsin deficiency: an Italian perspective

Author

ALIBERTI, Stefano, primary, AMATI, Francesco, additional, ANNUNZIATA, Anna, additional, ARCOLEO, Francesco, additional, BADERNA, Paolo, additional, BINI, Francesco, additional, CARRARO, Chiara F., additional, IANNACCI, Leonardo, additional, LO CICERO, Salvatore, additional, PASSALACQUA, Giovanni, additional, PILONI, Davide, additional, SCIOSCIA, Giulia, additional, SEEBACHER, Christine, additional, SORTINO, Elisabetta, additional, SPACONE, Antonella, additional, and VIANELLO, Andrea, additional

Published
2022
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19. Nutritional assessment in idiopathic pulmonary fibrosis: a prospective multicentre study

Author

Faverio, Paola, primary, Fumagalli, Alessia, additional, Conti, Sara, additional, Madotto, Fabiana, additional, Bini, Francesco, additional, Harari, Sergio, additional, Mondoni, Michele, additional, Oggionni, Tiberio, additional, Barisione, Emanuela, additional, Ceruti, Paolo, additional, Papetti, Maria Chiara, additional, Bodini, Bruno Dino, additional, Caminati, Antonella, additional, Valentino, Angela, additional, Centanni, Stefano, additional, Noè, Donatella, additional, Della Zoppa, Matteo, additional, Crotti, Silvia, additional, Grosso, Marco, additional, Sukkar, Samir Giuseppe, additional, Modina, Denise, additional, Andreoli, Marco, additional, Nicali, Roberta, additional, Suigo, Giulia, additional, De Giacomi, Federica, additional, Busnelli, Sara, additional, Cattaneo, Elena, additional, Mantovani, Lorenzo Giovanni, additional, Cesana, Giancarlo, additional, Pesci, Alberto, additional, and Luppi, Fabrizio, additional

Published
2021
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21. Predictors of worse prognosis in young adults hospitalized with COVID-19 pneumonia: a multi-center Italian study (COVID-UNDER50)

Author

Bonifazi, Martina, primary, Mei, Federico, additional, Skrami, Edlira, additional, Carle, Flavia, additional, Gasparini, Stefano, additional, Zuccatosta, Lina, additional, Di Marco Berardino, Alessandro, additional, Amico, Donatella, additional, Balestro, Elisabetta, additional, Bini, Francesco, additional, Candoli, Piero, additional, Caminati, Antonella, additional, Harari, Sergio, additional, Marchetti, Giampietro, additional, Levi, Guido, additional, Piciucchi, Sara, additional, Poletti, Venerino, additional, Ravaglia, Claudia, additional, Lococo, Sara, additional, Saetta, Marina, additional, Tomassetti, Sara, additional, Tamburrini, Mario, additional, Zuccon, Umberto, additional, Zanforlin, Alessandro, additional, and Menditto, Vincenzo, additional

Published
2021
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27. Nutritional assessment in patients with idiopathic pulmonary fibrosis: the NUTRIPF study

Author

Faverio, Paola, primary, Fumagalli, Alessia, additional, Conti, Sara, additional, Madotto, Fabiana, additional, Busnelli, Sara, additional, Bini, Francesco, additional, Harari, Sergio, additional, Mondoni, Michele, additional, Oggionni, Tiberio, additional, Barisione, Emanuela, additional, Ceruti, Paolo, additional, Papetti, Chiara, additional, De Laurentis, Angelo, additional, Caminati, Antonella, additional, Valentino, Angela, additional, Centanni, Stefano, additional, Noè, Donatella, additional, Della Zoppa, Matteo, additional, Crotti, Silvia, additional, Grosso, Marco, additional, Sukkar, Samir Giuseppe, additional, Modina, Denise, additional, Andreoli, Marco, additional, Nicali, Roberta, additional, Suigo, Giulia, additional, De Giacomi, Federica, additional, Mantovani, Lorenzo Giovanni, additional, Pesci, Alberto, additional, and Luppi, Fabrizio, additional

Published
2021
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31. Six-month pulmonary impairment after severe COVID-19: a prospective, multicenter follow-up study

Author

Faverio, Paola, primary, Luppi, Fabrizio, additional, Rebora, Paola, additional, Busnelli, Sara, additional, Stainer, Anna, additional, Catalano, Martina, additional, Parachini, Luca, additional, Monzani, Anna, additional, Galimberti, Stefania, additional, Bini, Francesco, additional, Bodini, Bruno Dino, additional, Betti, Monia, additional, Giacomi, Federica De, additional, Scarpazza, Paolo, additional, Oggionni, Elisa, additional, Scartabellati, Alessandro, additional, Bilucaglia, Luca, additional, Ceruti, Paolo, additional, Modina, Denise, additional, Harari, Sergio, additional, Caminati, Antonella, additional, Valsecchi, Maria Grazia, additional, Bellani, Giacomo, additional, Foti, Giuseppe, additional, and Pesci, Alberto, additional

Published
2021
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32. Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)

Author

Bonifazi, Martina, primary, Mei, Federico, additional, Skrami, Edlira, additional, Latini, Lara Letizia, additional, Amico, Donatella, additional, Balestro, Elisabetta, additional, Bini, Francesco, additional, Bonifazi, Floriano, additional, Caminati, Antonella, additional, Candoli, Piero, additional, Cinti, Saverio, additional, Contucci, Susanna, additional, Di Marco Berardino, Alessandro, additional, Harari, Sergio, additional, Levi, Guido, additional, Lococo, Sara, additional, Menditto, Vincenzo, additional, Marchetti, Giampietro, additional, Piciucchi, Sara, additional, Poletti, Venerino, additional, Ravaglia, Claudia, additional, Saetta, Marina, additional, Svegliati-Baroni, Gianluca, additional, Tomassetti, Sara, additional, Tamburrini, Mario, additional, Zanforlin, Alessandro, additional, Zuccon, Umberto, additional, Zuccatosta, Lina, additional, Gasparini, Stefano, additional, and Carle, Flavia, additional

Published
2021
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36. Severe asthma in adults does not significantly affect the outcome of COVID‐19 disease: Results from the Italian Severe Asthma Registry

Author

Antonicelli, Leonardo, primary, Tontini, Chiara, additional, Manzotti, Giuseppina, additional, Ronchi, Luca, additional, Vaghi, Adriano, additional, Bini, Francesco, additional, Scartabellati, Alessandro, additional, Menzella, Francesco, additional, De Michele, Fausto, additional, Musarra, Antonino, additional, Micheletto, Claudio, additional, and Bilò, Maria Beatrice, additional

Published
2020
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42. Six-Month Pulmonary Impairment after Severe COVID-19: A Prospective, Multicentre Follow-Up Study.

Author

Faverio, Paola, Luppi, Fabrizio, Rebora, Paola, Busnelli, Sara, Stainer, Anna, Catalano, Martina, Parachini, Luca, Monzani, Anna, Galimberti, Stefania, Bini, Francesco, Bodini, Bruno Dino, Betti, Monia, De Giacomi, Federica, Scarpazza, Paolo, Oggionni, Elisa, Scartabellati, Alessandro, Bilucaglia, Luca, Ceruti, Paolo, Modina, Denise, and Harari, Sergio

Subjects
PNEUMONIA, PATIENT aftercare, RESEARCH, COVID-19, SCIENTIFIC observation, CHEST X rays, CARBON monoxide, MEDICAL cooperation, PULMONARY function tests, PULMONARY fibrosis, COVID-19 pandemic, LONGITUDINAL method
Abstract

Background: Long-term pulmonary sequelae following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia are not yet confirmed; however, preliminary observations suggest a possible relevant clinical, functional, and radiological impairment. Objectives: The aim of this study was to identify and characterize pulmonary sequelae caused by SARS-CoV-2 pneumonia at 6-month follow-up. Methods: In this multicentre, prospective, observational cohort study, patients hospitalized for SARS-CoV-2 pneumonia and without prior diagnosis of structural lung diseases were stratified by maximum ventilatory support ("oxygen only," "continuous positive airway pressure," and "invasive mechanical ventilation") and followed up at 6 months from discharge. Pulmonary function tests and diffusion capacity for carbon monoxide (DLCO), 6-min walking test, chest X-ray, physical examination, and modified Medical Research Council (mMRC) dyspnoea score were collected. Results: Between March and June 2020, 312 patients were enrolled (83, 27% women; median interquartile range age 61.1 [53.4, 69.3] years). The parameters that showed the highest rate of impairment were DLCO and chest X-ray, in 46% and 25% of patients, respectively. However, only a minority of patients reported dyspnoea (31%), defined as mMRC ≥1, or showed restrictive ventilatory defects (9%). In the logistic regression model, having asthma as a comorbidity was associated with DLCO impairment at follow-up, while prophylactic heparin administration during hospitalization appeared as a protective factor. The need for invasive ventilatory support during hospitalization was associated with chest imaging abnormalities. Conclusions: DLCO and radiological assessment appear to be the most sensitive tools to monitor patients with the coronavirus disease 2019 (COVID-19) during follow-up. Future studies with longer follow-up are warranted to better understand pulmonary sequelae. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Predictors of Worse Prognosis in Young Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)

Author

Bonifazi, Martina, primary, Mei, Federico, additional, Skrami, Edlira, additional, Latini, Lara Letizia, additional, Amico, Donatella, additional, Balestro, Elisabetta, additional, Bini, Francesco, additional, Bonifazi, Floriano, additional, Caminati, Antonella, additional, candoli, piero, additional, Cinti, Saverio, additional, di marco berardino, alessandro, additional, Contucci, Susanna, additional, harari, sergio, additional, levi, guido, additional, lococo, sara, additional, Menditto, Vincenzo, additional, marchetti, giampietro, additional, Piciucchi, Sara, additional, Poletti, Venerino, additional, Ravaglia, Claudia, additional, Saetta, Marina, additional, Svegliati Baroni, Gianluca, additional, Tomassetti, Sara, additional, Tamburrini, Mario, additional, Zanforlin, Alessandro, additional, Zuccon, Umberto, additional, Zuccatosta, Lina, additional, Gasparini, Stefano, additional, and Carle, Flavia, additional

Published
2020
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45. Mepolizumab as the first targeted treatment for eosinophilic granulomatosis with polyangiitis: a review of current evidence and potential place in therapy

Author

Faverio,Paola, Bonaiti,Giulia, Bini,Francesco, Vaghi,Adriano, and Pesci,Alberto

Subjects
Therapeutics and Clinical Risk Management
Abstract

Paola Faverio,1,2 Giulia Bonaiti,1,2 Francesco Bini,3 Adriano Vaghi,3 Alberto Pesci1,2 1School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; 2Respiratory Unit, San Gerardo Hospital, ASST di Monza, Monza, Italy; 3ASST-Rhodense, UOC Pneumologia, Garbagnate Milanese, Milan, Italy Abstract: Mepolizumab is an anti-interleukin-5 (IL-5) humanized monoclonal antibody that binds to free IL-5. It induces bone marrow eosinophil maturation arrest and decreases eosinophil progenitors and subsequent maturation in the blood and bronchial mucosa. Its use has been extensively studied in severe eosinophilic asthma at a dose of 100 mg subcutaneously (SC) every 4 weeks and, more recently, in other hypereosinophilic syndromes. Eosinophilic granulomatosis with polyangiitis (EGPA) is an eosinophilic vasculitis that may involve multiple organs. Characteristic clinical manifestations are asthma, sinusitis, transient pulmonary infiltrates and neuropathy. Among the numerous pathways involved in the pathogenesis of EGPA, the Th-2 phenotype has a main role, as suggested by the prominence of the asthmatic component, in triggering the release of key cytokines for the activation, maturation and survival of eosinophils. In particular, IL-5 is highly increased in active EGPA and its inhibition can represent a potential therapeutic target. In this scenario, mepolizumab may play a therapeutic role. After some positive preliminary observations on the use of mepolizumab in small case series of EGPA patients with refractory or relapsing disease despite standard of care treatment, a randomized controlled trial was published in 2017. Mepolizumab at a dose of 300 mg administered by SC injection every 4 weeks proved effective in prolonging the period of remission of the disease, allowing for reduced steroid use. The positive results of this study, which met both of the primary endpoints, led to the approval in the USA of mepolizumab in adult patients with EGPA by the Food and Drug Administration in 2017. Therefore, mepolizumab can be officially considered as an add-on therapy with steroid-sparing effect in cases of relapsing or refractory EGPA. However, the most appropriate dose and duration of therapy still need to be determined. Future studies on larger multinational populations with prolonged follow-up are warranted. Keywords: mepolizumab, eosinophilic granulomatosis with polyangiitis, Churg–Strauss syndrome

Published
2018

49. Management of Chronic Respiratory Failure in Interstitial Lung Diseases: Overview and Clinical Insights

Author

Faverio, P, De Giacomi, F, Bonaiti, G, Stainer, A, Sardella, L, Pellegrino, G, Sferrazza Papa, G, Bini, F, Bodini, B, Carone, M, Annoni, S, Messinesi, G, Pesci, A, Faverio, Paola, De Giacomi, Federica, Bonaiti, Giulia, Stainer, Anna, Sardella, Luca, Pellegrino, Giulia, Sferrazza Papa, Giuseppe Francesco, Bini, Francesco, Bodini, Bruno Dino, Carone, Mauro, Annoni, Sara, Messinesi, Grazia, Pesci, Alberto, Faverio, P, De Giacomi, F, Bonaiti, G, Stainer, A, Sardella, L, Pellegrino, G, Sferrazza Papa, G, Bini, F, Bodini, B, Carone, M, Annoni, S, Messinesi, G, Pesci, A, Faverio, Paola, De Giacomi, Federica, Bonaiti, Giulia, Stainer, Anna, Sardella, Luca, Pellegrino, Giulia, Sferrazza Papa, Giuseppe Francesco, Bini, Francesco, Bodini, Bruno Dino, Carone, Mauro, Annoni, Sara, Messinesi, Grazia, and Pesci, Alberto

Abstract

Interstitial lung diseases (ILDs) may be complicated by chronic respiratory failure (CRF), especially in the advanced stages. Aim of this narrative review is to evaluate the current evidence in management of CRF in ILDs.Many physiological mechanisms underlie CRF in ILDs, including lung restriction, ventilation/perfusion mismatch, impaired diffusion capacity and pulmonary vascular damage. Intermittent exertional hypoxemia is often the initial sign of CRF, evolving, as ILD progresses, into continuous hypoxemia. In the majority of the cases, the development of CRF is secondary to the worsening of the underlying disease; however, associated comorbidities may also play a role. When managing CRF in ILDs, the need for pulmonary rehabilitation, the referral to lung transplant centers and palliative care should be assessed and, if necessary, promptly offered. Long-term oxygen therapy is commonly prescribed in case of resting or exertional hypoxemia with the purpose to decrease dyspnea and improve exercise tolerance. High-Flow Nasal Cannula oxygen therapy may be used as an alternative to conventional oxygen therapy for ILD patients with severe hypoxemia requiring both high flows and high oxygen concentrations. Non-Invasive Ventilation may be used in the chronic setting for palliation of end-stage ILD patients, although the evidence to support this application is very limited.

Published
2019

50. Management of Chronic Respiratory Failure in Interstitial Lung Diseases: Overview and Clinical Insights

Author

Faverio, Paola, primary, De Giacomi, Federica, additional, Bonaiti, Giulia, additional, Stainer, Anna, additional, Sardella, Luca, additional, Pellegrino, Giulia, additional, Sferrazza Papa, Giuseppe Francesco, additional, Bini, Francesco, additional, Bodini, Bruno Dino, additional, Carone, Mauro, additional, Annoni, Sara, additional, Messinesi, Grazia, additional, and Pesci, Alberto, additional

Published
2019
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