233 results on '"Bird, Gregory H."'
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2. Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency
3. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering
4. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer
5. A redox switch regulates the structure and function of anti-apoptotic BFL-1
6. Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation
7. Dissecting the neuroprotective interaction between the BH4 domain of BCL-w and the IP3 receptor
8. Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells
9. Data from MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
10. Supplementary Figures S1-S7 from MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
11. Supplementary Tables S1-S7 from MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
12. Supplementary Methods on Data Analysis from MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
13. Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors
14. Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices
15. Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function
16. Multimodal Interaction with BCL-2 Family Proteins Underlies the Proapoptotic Activity of PUMA BH3
17. Direct activation of full-length proapoptotic BAK
18. Generation of Potent and Stable GLP-1 Analogues Via “Serine Ligation”
19. Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies
20. Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic
21. Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection
22. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets
23. Photoreactive Stapled Peptides to Identify and Characterize BCL-2 Family Interaction Sites by Mass Spectrometry
24. A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
25. BAX activation is initiated at a novel interaction site
26. Dual role of proapoptotic BAD in insulin secretion and beta cell survival
27. Characterizing Native and Hydrocarbon-Stapled Enfuvirtide Conformations with Ion Mobility Mass Spectrometry and Hydrogen–Deuterium Exchange
28. Glucose Metabolism and Pyruvate Carboxylase Enhanceglutathione Synthesis and Restrict Oxidative Stress in Beta-Cells
29. Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival
30. Manipulation of temperature to improve solubility of hydrophobic proteins and cocrystallization with matrix for analysis by MALDI-TOF mass spectrometry
31. Chapter 22 Synthesis and Biophysical Characterization of Stabilized α‐Helices of BCL‐2 Domains
32. Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor
33. Fast Transport of RNA Granules by Direct Interactions with KIF5A/KLC1 Motors Prevents Axon Degeneration
34. Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors
35. MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
36. MALDI-TOF mass spectrometry characterization of recombinant hydrophobic mutants containing the GCN4 basic region/leucine zipper motif
37. Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer
38. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma
39. Abstract 1901: Structural basis for selective therapeutic targeting of BFL-1 in cancer by a covalent stapled peptide inhibitor
40. Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD
41. Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells
42. Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor
43. Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration
44. Abstract 2024: Reactivating apoptosis in BFL-1/A1 driven cancer with cysteine-reactive stapled peptide inhibitors
45. Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides
46. Challenges in Targeting a Basic Helix–Loop–Helix Transcription Factor with Hydrocarbon-Stapled Peptides
47. Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices
48. Abstract 3845: A novel selectivity determinant informs the development of next-generation stapled peptide inhibitors of anti-apoptotic BFL-1/A1
49. Abstract 3553: A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1
50. Allosteric inhibition of antiapoptotic MCL-1
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