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Pre-Pulse Inhibition (PPI) is a neural process where suppression of a startle response is elicited by preceding the startling stimulus (Pulse) with a weak, non-startling one (Pre-Pulse). Defective PPI is widely employed as a behavioural endophenotype in humans and mammalian disorder-relevant models for neuropsychiatric disorders. We have developed a user-friendly, semi-automated, high-throughput-compatible Drosophila light-off jump response PPI paradigm, with which we demonstrate that PPI, with similar parameters measured in mammals, exists in adults of this model organism. We report that Drosophila PPI is affected by reduced expression of Dysbindin and both reduced and increased expression of Nmdar1 (N-methyl-D-aspartate receptor 1), perturbations associated with schizophrenia. Studying the biology of PPI in an organism that offers a plethora of genetic tools and a complex and well characterized connectome will greatly facilitate our efforts to gain deeper insight into the aetiology of human mental disorders, while reducing the need for mammalian models., Competing Interests: Additional Declarations: Yes there is potential Competing Interest. Z.A. is a director and shareholder of Aktogen Ltd. and Aktogen Hungary Ltd. L.A. is a director of Aktogen Ltd.. The commercial light-off jump PPI system is developed and manufactured by Aktogen Ltd. All other authors report no biomedical financial interests or potential conflicts of interest. Conflict of interest statements Z.A. is a director and shareholder of Aktogen Ltd. and Aktogen Hungary Ltd. L.A. is a director of Aktogen Ltd.. The commercial light-off jump PPI system is developed and manufactured by Aktogen Ltd. All other authors report no biomedical financial interests or potential conflicts of interest.