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16 results on '"Birtles, Andrew"'

4. An Overview of SARS-CoV-2 Molecular Diagnostics in Europe

Author

Davies, Emma, primary, Farooq, Hamzah Z., additional, Brown, Benjamin, additional, Tilston, Peter, additional, McEwan, Ashley, additional, Birtles, Andrew, additional, O’Hara, Robert William, additional, Ahmad, Shazaad, additional, Machin, Nicholas, additional, Hesketh, Louise, additional, and Guiver, Malcolm, additional

Published
2022
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5. Real-world SARS CoV-2 testing in Northern England during the first wave of the COVID-19 pandemic

Author

Farooq, Hamzah Z., primary, Davies, Emma, additional, Brown, Benjamin, additional, Whitfield, Thomas, additional, Tilston, Peter, additional, McEwan, Ashley, additional, Birtles, Andrew, additional, O'Hara, Robert, additional, Spencer, Hannah, additional, Hesketh, Louise, additional, Ahmad, Shazaad, additional, Guiver, Malcolm, additional, and Machin, Nicholas, additional

Published
2021
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6. Identification of potential environmentally adapted Campylobactor jejuni strain, United Kingdom

Author

Sopwith, Will, Birtles, Andrew, Matthews, Margaret, Fox, Andrew, Gee, Steven, Painter, Michael, Regan, Martyn, Syed, Qutub, and Bolton, Eric

Subjects
Livestock -- Health aspects, Infection -- Health aspects, Medical research -- Health aspects, Medicine, Experimental -- Health aspects
Abstract

In a study of Campylobacter infection in northwestern England, 2003-2006, C. jejuni multilocus sequence type (ST)-45 was associated with early summer onset and was the most prevalent C. jejuni type [...]

Published
2008

7. Campylobacter jejuni multilocus sequence types in humans, northwest England, 2003-2004

Author

Sopwith, Will, Birtles, Andrew, Matthews, Margaret, Fox, Andrew, Gee, Steven, Painter, Michael, Regan, Martyn, Syed, Qutub, and Bolton, Eric

Subjects
Campylobacter -- Research, Campylobacter infections -- Research, Epidemics -- England, Epidemics -- Research
Abstract

Detailed understanding of the epidemiology of Campylobacter is increasingly facilitated through use of universal and reproducible techniques for accurate strain differentiation and subtyping. Multilocus sequence typing (MLST) enables discriminatory subtyping [...]

Published
2006

9. Investigation of food and environment exposures relating to the epidemiology of Campylobacter coli in humans in Northwest England

Author

Sopwith, Will, Birtles, Andrew, Matthews, Margaret, Fox, Andrew, Gee, Steven, James, Sam, Kempster, Jeanette, Painter, Michael, Edwards-Jones, Val, Osborn, Keith, Regan, Martyn, Syed, Qutub, and Bolton, Eric

Subjects
Campylobacter -- Genetic aspects, Campylobacter -- Physiological aspects, Nucleotide sequencing -- Usage, Public health -- Management, Company business management, Biological sciences
Abstract

Multilocus sequence typing (MLST) is used for examining the epidemiology of Campylobacter coli in a continuous study of a population in Northwest England. The studies have provided very little evidence to indicate that epidemiological differences between human cases of C. coli and C. jejuni are a result of different food or behavioral exposures alone.

Published
2010

10. Longitudinal study of the molecular epidemiology of Campylobacter jejuni in cattle on dairy farms

Author

Kwan, Patrick S.L., Birtles, Andrew, Bolton, Frederick J., French, Nigel P., Robinson, Susan E., Newbold, Lynne S., Upton, Matthew, and Fox, Andrew J.

Subjects
Campylobacter -- Genetic aspects, Campylobacter -- Health aspects, Cladistic analysis -- Usage, Gastroenteritis -- Causes of, Gastroenteritis -- Development and progression, Biological sciences
Abstract

The role of cattle on dairy farms as a source for zoonotic Campylobacter jejuni infections in human is examined. Findings reveal that cattle can cause human Campylobacter gastroenteritis.

Published
2008

11. Campylobacter jejuni multilocus sequence types in humans, northwest England, 2003-2004

Author

Fox, Andrew J., Sopwith, Will, Birtles, Andrew, and Matthews, Margaret

Abstract

Detailed understanding of the epidemiology of Campylobacter is increasingly facilitated through use of universal and reproducible techniques for accurate strain differentiation and subtyping. Multilocus sequence typing (MLST) enables discriminatory subtyping and grouping of isolate types into genetically related clonal complexes; it also has the advantage of ease of application and repeatability. Recent studies suggest that a measure of host association may be distinguishable with this system. We describe the first continuous population-based survey to investigate the potential of MLST to resolve questions of campylobacteriosis epidemiology. We demonstrate the ability of MLST to identify variations in the epidemiology of campylobacteriosis between distinct populations and describe the distribution of key subtypes of interest.

Published
2006

16. Multilocus Sequence Typing of Neisseria meningitidisDirectly from Clinical Samples and Application of the Method to the Investigation of Meningococcal Disease Case Clusters

Author

Birtles, Andrew, Hardy, Katie, Gray, Stephen J., Handford, Suzanne, Kaczmarski, Edward B., Edwards-Jones, Valerie, and Fox, Andrew J.

Abstract

ABSTRACTInfections associated with Neisseria meningitidisare a major public health problem in England, Wales, and Northern Ireland. Currently, over 40% of cases are confirmed directly from clinical specimens using PCR-based methodologies without an organism being isolated. A nested/seminested multilocus sequence typing (MLST) system was developed at the Health Protection Agency Meningococcal Reference Unit to allow strain characterization beyond the serogroup for cases confirmed by PCR only. This system was evaluated on a panel of 20 meningococcus-positive clinical specimens (3 cerebrospinal fluid and 17 blood samples) from different patients containing various concentrations of meningococcal DNA that had corresponding N. meningitidisisolates. In each case, the sequence type generated from the clinical specimens matched that produced from the corresponding N. meningitidisisolate; the sensitivity of the MLST system was determined to be less than 12 genome copies per PCR. The MLST system was then applied to 15 PCR meningococcus-positive specimens (2 cerebrospinal fluid and 13 blood samples), each from a different patient, involved in three case clusters (two serogroup B and one serogroup W135) for which no corresponding N. meningitidisorganisms had been isolated. In each case, an MLST sequence type was generated, allowing the accurate assignment of individual cases within each of the case clusters. In summary, the adaptation of the N. meningitidisMLST to a sensitive nested/seminested format for strain characterization directly from clinical specimens provides an important tool for surveillance and management of meningococcal infection.

Published
2005
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