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Author(s): Gebeyaw Biset [sup.1] , Kibret Ameha [sup.2] , Awraris Hailu [sup.3] , Yohannes Kibret [sup.2] Author Affiliations: (1) grid.467130.7, 0000 0004 0515 5212, Department of Paediatric and Child Health [...], Background Suboptimal breastfeeding causes substantial numbers of child morbidity and mortality in Ethiopia. This study was designed to assess suboptimal breastfeeding practice and its associated factors among children age less than two years in South Wollo, northeast Ethiopia. Method A community-based cross-sectional study was conducted among 636 women-child pairs. The study participants were selected by a multi sage random sampling technique. Data were collected using a structured interviewer-administered questionnaire, then it was entered into Epi-Data version 3.1, and exported into SPSS version 24.0 for analysis. A Binary Logistic Regression Model with a backward elimination method was used to determine the association of factors and suboptimal breastfeeding practice of babies at a 95% confidence interval. Result Six hundred and thirty-six participants were included with a response rate of 99.7%. The study showed that 36.3% babies age less than 2 years were received suboptimal breastfeeding. Cesarean delivery [AOR: 8.81; 95% CI (4.92-15.77)], lack of breastfeeding counseling [AOR: 3.22; 95% CI (1.93-5.36)], maternal feeding less than 5 times/day during breastfeeding [AOR: 2.01; 95% CI (1.20-3.34)], child health problems [AOR: 3.57; 95%CI (2.17-5.85)], and babies age less than 6 months [AOR:1.92; 95%CI (1.24-2.97)] were positively associated with suboptimal breastfeeding practice. Conclusion Suboptimal breastfeeding practice is highly prevalent in Ethiopia. Health service-related and socio-cultural factors were associated with the high prevalence of suboptimal breastfeeding practice. Emphasis should be given to the breastfeeding practices of children age less than years in Ethiopia. Moreover, counseling regarding the importance of breastfeeding practices should be strengthened.

Background: The use of Clean Delivery Kits (CDKs) promotes healthy birth outcome. Nevertheless, representative data are lacking for low- and middle-income countries. Thus, study aimed at determining the overall estimate of clean delivery kit use among low and middle income countries. Methods: A comprehensive review of the Science Direct, Scopus, Google Scholar, EMBASE, and PubMed databases was part of the current investigation. Microsoft Excel (version 14) was used to extract the data, and STATA statistical software was used for analysis. The presence of publication bias was assessed using DOI Plots in the study. By calculating I2 and doing an overall estimation analysis, heterogeneity was evaluated. Furthermore, a subgroup analysis was carried out according to the sample size, publication year, and study design. Results: Out of 654 articles, 12 met the inclusion criteria and were included in the analysis, covering 19,889 study participants. In low- and middle-income countries, the pooled proportion of clean delivery kits use was 54% (95%CI: 31. 60, 76.82, I2 = 70%). Notably, the cross-sectional study revealed the lowest incidence of delivery kit use, with a proportion of 54.29%, while the cohort study revealed the highest proportion, at 72.37%. In studies with sample sizes < 500, clean delivery kit use was higher (60.28%) compared to studies with sample sizes > 500 (45.75%). Lastly, the proportion of clean delivery kits was found to be 62.53% for studies published after 2010, compared to 48.25% for studies published before 2010. Conclusion: In summary, the proportion of clean delivery kits use was 54%. Healthcare systems should focus on different strategies to improve clean delivery kit use. [ABSTRACT FROM AUTHOR]

Background: Opportunistic infections are the major causes for morbidity and mortality due to HIV infections. Despite advances in HIV diagnosis and management, the incidence of opportunistic infections remains high. This study aimed to assess the incidence and predictors of opportunistic infections among persons living with HIV/AIDS in Ethiopia. Methods: A retrospective follow-up study was conducted on 354 samples of adults living with HIV on antiretroviral therapy at Dessie Comprehensive Specialized Hospital. Simple random sampling technique was used to select study participants. The data collection format was taken from national antiretroviral intake and follow-up forms. Epi-data Version 4.6.1 and STATA Version 16 software were used for data entry and data analysis respectively. The Cox-proportional hazards regression model was fitted. Kaplan–Meier survival curve was used to estimate opportunistic infections-free survival time. Both bi-variable and multivariable Cox-proportional hazard regression analysis were done to identify predictors of opportunistic infections. Results: Of the total 354 peoples living with HIV, 114 (32.2%) developed OI, with an incidence rate of 13.5 per 100 person-year (95% CI: 10.8– 15.6). Advanced World Health Organization clinical disease stage (IV) (AHR: 2.1 (95% CI: 1.16, 3.8)), being bedridden (AHR: 1.66 (95% CI: 1.04, 2.65)), poor adherence (AHR: 1.7 (95% CI: 1.1– 2.63), and low CD4 count (AHR: 1.92 95% CI: 1.14– 3.22) were significant predictors of OIs. Conclusion: Opportunistic infection among HIV/AIDS continues to be a significant public health concern in Ethiopian health care setting. Our results indicate that the incidence of OI is high. Besides, Stage IV HIV status, being bedridden, low CD4 count and poor adherence independently predicts an increased incidence/decreased survival time of OIs among PLWHIV. Early care-seeking and initiation of HAART and continuous follow-up of patients to take their drug timely are essential to curb the incidence of opportunistic infections and improve overall health. Further research on this area is highly recommended. [ABSTRACT FROM AUTHOR]

Background: Opportunistic infections are the major causes for morbidity and mortality due to HIV infections. Despite advances in HIV diagnosis and management, the incidence of opportunistic infections remains high. This study aimed to assess the incidence and predictors of opportunistic infections among persons living with HIV/AIDS in Ethiopia., Methods: A retrospective follow-up study was conducted on 354 samples of adults living with HIV on antiretroviral therapy at Dessie Comprehensive Specialized Hospital. Simple random sampling technique was used to select study participants. The data collection format was taken from national antiretroviral intake and follow-up forms. Epi-data Version 4.6.1 and STATA Version 16 software were used for data entry and data analysis respectively. The Cox-proportional hazards regression model was fitted. Kaplan-Meier survival curve was used to estimate opportunistic infections-free survival time. Both bi-variable and multivariable Cox-proportional hazard regression analysis were done to identify predictors of opportunistic infections., Results: Of the total 354 peoples living with HIV, 114 (32.2%) developed OI, with an incidence rate of 13.5 per 100 person-year (95% CI: 10.8-15.6). Advanced World Health Organization clinical disease stage (IV) (AHR: 2.1 (95% CI: 1.16, 3.8)), being bedridden (AHR: 1.66 (95% CI: 1.04, 2.65)), poor adherence (AHR: 1.7 (95% CI: 1.1-2.63), and low CD4 count (AHR: 1.92 95% CI: 1.14-3.22) were significant predictors of OIs., Conclusion: Opportunistic infection among HIV/AIDS continues to be a significant public health concern in Ethiopian health care setting. Our results indicate that the incidence of OI is high. Besides, Stage IV HIV status, being bedridden, low CD4 count and poor adherence independently predicts an increased incidence/decreased survival time of OIs among PLWHIV. Early care-seeking and initiation of HAART and continuous follow-up of patients to take their drug timely are essential to curb the incidence of opportunistic infections and improve overall health. Further research on this area is highly recommended., Competing Interests: The authors declare that they have no competing interests., (© 2022 Dagnaw Tegegne et al.)