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20 results on '"Biswas, Sreya"'

2. SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo

Author

Derby, Nina, primary, Biswas, Sreya, additional, Yusova, Sofiya, additional, Luevano-Santos, Cristina, additional, Pacheco, Maria Cristina, additional, Meyer, Kimberly A., additional, Johnson, Brooke I., additional, Fischer, Miranda, additional, Fancher, Katherine A., additional, Fisher, Cole, additional, Abraham, Yohannes, additional, McMahon, Conor J., additional, Lutz, Savannah S., additional, Smedley, Jeremy V., additional, Burwitz, Benjamin J., additional, and Sodora, Donald L., additional

Published
2024
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4. Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection

Author

Ricciardi, Michael J., primary, Rust, Lauren N., additional, Pedreño-Lopez, Nuria, additional, Yusova, Sofiya, additional, Biswas, Sreya, additional, Webb, Gabriela M., additional, Gonzalez-Nieto, Lucas, additional, Voigt, Thomas B., additional, Louw, Johan J., additional, Laurino, Fernanda D., additional, DiBello, John R., additional, Raué, Hans-Peter, additional, Barber-Axthelm, Aaron M., additional, Chun, Kimberly, additional, Uttke, Samantha, additional, Raphael, Lidiane M. S., additional, Yrizarry-Medina, Aaron, additional, Rosen, Brandon C., additional, Agnor, Rebecca, additional, Gao, Lina, additional, Labriola, Caralyn, additional, Axthelm, Michael, additional, Smedley, Jeremy, additional, Julander, Justin G., additional, Bonaldo, Myrna C., additional, Walker, Laura M., additional, Messaoudi, Ilhem, additional, Slifka, Mark K., additional, Burton, Dennis R., additional, Kallas, Esper G., additional, Sacha, Jonah B., additional, Watkins, David I., additional, and Burwitz, Benjamin J., additional

Published
2023
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5. Therapeutic neutralizing monoclonal antibody administration protects against lethal viscerotropic Yellow Fever infection

Author

Ricciardi, Michael J., primary, Rust, Lauren N., additional, Pedreño-Lopez, Nuria, additional, Yusova, Sofiya, additional, Biswas, Sreya, additional, Webb, Gabriela M., additional, Fischer, Miranda, additional, Gonsales-Nieto, Lucas, additional, Voigt, Thomas B., additional, Louw, Johan J., additional, Laurino, Fernanda D., additional, DiBello, John R., additional, Raué, Hans-Peter, additional, Raphael, Lidiane M.S., additional, Yrizarry-Medina, Aaron, additional, Rosen, Brandon C., additional, Agnor, Rebecca, additional, Gao, Lina, additional, Labriola, Caralyn, additional, Axthelm, Michael, additional, Smedley, Jeremy, additional, Julander, Justin G., additional, Bonaldo, Myrna C., additional, Walker, Laura M., additional, Slifka, Mark K., additional, Messaoudi, Ilhem, additional, Burton, Dennis R., additional, Kallas, Esper G., additional, Sacha, Jonah B., additional, Watkins, David I., additional, and Burwitz, Benjamin J., additional

Published
2022
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7. Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in Mice

Author

Belayet, Jawad B., primary, Beamish, Sarah, additional, Rahaman, Mizzanoor, additional, Alanani, Samer, additional, Virdi, Rajdeep S., additional, Frick, David N., additional, Rahman, A. F. M. Towheedur, additional, Ulicki, Joseph S., additional, Biswas, Sreya, additional, Arnold, Leggy A., additional, Roni, M. S. Rashid, additional, Cheng, Eric Y., additional, Steeber, Douglas A., additional, Frick, Karyn M., additional, and Hossain, M. Mahmun, additional

Published
2022
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8. MHC-E–Restricted CD8+ T Cells Target Hepatitis B Virus–Infected Human Hepatocytes

Author

Burwitz, Benjamin J., primary, Hashiguchi, Patrick K., additional, Mansouri, Mandana, additional, Meyer, Christine, additional, Gilbride, Roxanne M., additional, Biswas, Sreya, additional, Womack, Jennie L., additional, Reed, Jason S., additional, Wu, Helen L., additional, Axthelm, Michael K., additional, Hansen, Scott G., additional, Picker, Louis J., additional, Früh, Klaus, additional, and Sacha, Jonah B., additional

Published
2020
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9. Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensisMSMB43

Author

Liu, Xiangyang, Biswas, Sreya, Berg, Michael G., Antapli, Christopher M., Xie, Feng, Wang, Qi, Tang, Man-Cheng, Tang, Gong-Li, Zhang, Lixin, Dreyfuss, Gideon, and Cheng, Yi-Qiang

Abstract

Mining the genome sequence of Burkholderia thailandensisMSMB43 revealed a cryptic biosynthetic gene cluster resembling that of FR901464 (4), a prototype spliceosome inhibitor produced by Pseudomonassp. No. 2663. Transcriptional analysis revealed a cultivation condition in which a regulatory gene of the cryptic gene cluster is adequately expressed. Consequently, three new compounds, named thailanstatins A (1), B (2), and C (3), were isolated from the fermentation broth of B. thailandensisMSMB43. Thailanstatins are proposed to be biosynthesized by a hybrid polyketide synthase–nonribosomal peptide synthetase pathway. They differ from 4by lacking an unstable hydroxyl group and by having an extra carboxyl moiety; those differences endow thailanstatins with a significantly greater stability than 4as tested in phosphate buffer at pH 7.4. In vitroassays showed that thailanstatins inhibit pre-mRNA splicing as potently as 4, with half-maximal inhibitory concentrations in the single to sub-μM range. Cell culture assays indicated that thailanstatins also possess potent antiproliferative activities in representative human cancer cell lines, with half-maximal growth inhibitory concentrations in the single nM range. This work provides new chemical entities for research and development and new structure–activity information for chemical optimization of related spliceosome inhibitors.

Published
2024
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13. Abstract 2257: Thailanstatins: New pre-mRNA splicing inhibitors and potent antiproliferative agents discovered from Burkholderia Thailandensis MSMB43.

Author

Liu, Xiangyang, primary, Biswas, Sreya, additional, Berg, Michael G., additional, Antapli, Christopher M., additional, Xie, Feng, additional, Wang, Qi, additional, Tang, Man-Cheng, additional, Tang, Gong-Li, additional, Zhang, Lixin, additional, Dreyfuss, Gideon, additional, and Cheng, Yi-Qiang, additional

Published
2013
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14. Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43

Author

Liu, Xiangyang, primary, Biswas, Sreya, additional, Berg, Michael G., additional, Antapli, Christopher M., additional, Xie, Feng, additional, Wang, Qi, additional, Tang, Man-Cheng, additional, Tang, Gong-Li, additional, Zhang, Lixin, additional, Dreyfuss, Gideon, additional, and Cheng, Yi-Qiang, additional

Published
2013
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16. MHC-E-Restricted CD8+ T Cells Target Hepatitis B Virus-Infected Human Hepatocytes.

Author

Burwitz, Benjamin J., Hashiguchi, Patrick K., Mansouri, Mandana, Meyer, Christine, Gilbride, Roxanne M., Biswas, Sreya, Womack, Jennie L., Reed, Jason S., Wu, Helen L., Axthelm, Michael K., Hansen, Scott G., Picker, Louis J., Früh, Klaus, and Sacha, Jonah B.

Subjects
*T cells, *HEPATITIS B, *CHRONIC hepatitis B, *LIVER cells, *HEPATITIS B virus
Abstract

Currently 247 million people are living with chronic hepatitis B virus infection (CHB), and the development of novel curative treatments is urgently needed. Immunotherapy is an attractive approach to treat CHB, yet therapeutic approaches to augment the endogenous hepatitis B virus (HBV)-specific T cell response in CHB patients have demonstrated little success. In this study, we show that strain 68-1 rhesus macaque (RM) CMV vaccine vectors expressing HBV Ags engender HBV-specific CD8+ T cells unconventionally restricted by MHC class II and the nonclassical MHC-E molecule in RM. Surface staining of human donor and RM primary hepatocytes (PH) ex vivo revealed the majority of PH expressed MHC-E but not MHC class II. HBV-specific, MHCE-restricted CD8+ T cells from RM vaccinated with RM CMV vaccine vectors expressing HBVAgs recognized HBV-infected PH from both human donor and RM. These results provide proof-of-concept that MHC-E-restricted CD8+ T cells could be harnessed for the treatment of CHB, either through therapeutic vaccination or adoptive immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2020
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17. Horizon. The contraceptive pill : how safe is it?

Author

BBC Studios, production company., BBC Worldwide Ltd., film distributor., Sussman, Alicky, director, producer., Harrison-Hansley, Milla, director, producer., McKinder, Annie, producer., Biswas, Sreya, producer., and Williams, Zoe, 1980- speaker.

Published
2018

19. The British property boom

Author

BBC Worldwide Ltd., film distributor., Trelford, Dan, director, producer., Biswas, Sreya, producer., and Best, Eve, 1971- narrator.

Published
2014

20. MHC-E-Restricted CD8 + T Cells Target Hepatitis B Virus-Infected Human Hepatocytes.

Author

Burwitz BJ, Hashiguchi PK, Mansouri M, Meyer C, Gilbride RM, Biswas S, Womack JL, Reed JS, Wu HL, Axthelm MK, Hansen SG, Picker LJ, Früh K, and Sacha JB

Subjects
Animals, Hepatitis B, Chronic virology, Hepatocytes virology, Macaca mulatta, CD8-Positive T-Lymphocytes immunology, Hepatitis B virus immunology, Hepatitis B, Chronic immunology, Hepatocytes immunology, Histocompatibility Antigens Class I immunology
Abstract

Currently 247 million people are living with chronic hepatitis B virus infection (CHB), and the development of novel curative treatments is urgently needed. Immunotherapy is an attractive approach to treat CHB, yet therapeutic approaches to augment the endogenous hepatitis B virus (HBV)-specific T cell response in CHB patients have demonstrated little success. In this study, we show that strain 68-1 rhesus macaque (RM) CMV vaccine vectors expressing HBV Ags engender HBV-specific CD8 + T cells unconventionally restricted by MHC class II and the nonclassical MHC-E molecule in RM. Surface staining of human donor and RM primary hepatocytes (PH) ex vivo revealed the majority of PH expressed MHC-E but not MHC class II. HBV-specific, MHC-E-restricted CD8 + T cells from RM vaccinated with RM CMV vaccine vectors expressing HBV Ags recognized HBV-infected PH from both human donor and RM. These results provide proof-of-concept that MHC-E-restricted CD8 + T cells could be harnessed for the treatment of CHB, either through therapeutic vaccination or adoptive immunotherapy., (Copyright © 2020 by The American Association of Immunologists, Inc.)

Published
2020
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