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5. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Author

Sánchez, Fernando Fernández, de Lomas, José Mª García, Rosas, Gabriel, de la Torre Lima, Javier, Bereciartua, Elena, Vidal, María José Blanco, Blanco, Roberto, Boado, María Victoria, Lázaro, Marta Campaña, Crespo, Alejandro, Carrión, Laura Guio, Del Álamo Martínez de Lagos, Mikel, Ugarte, Gorane Euba, Goikoetxea, Ane Josune, Hierro, Marta Ibarrola, Iruretagoyena, José Ramón, Zuazabal, Josu Irurzun, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, López, Mª Victoria García, Georgieva, Radka Ivanova, Ojeda, Guillermo, Bailón, Isabel Rodríguez, Morales, Josefa Ruiz, Rodríguez, Ignacio Álvarez, Galparsoro, Harkaitz Azkune, Boronat, Elisa Berritu, Odriozola, Mª Jesús Bustinduy, del Bosque Martín, Cristina, Echeverría, Tomás, Yarza, Alberto Eizaguirre, Fuentes, Ana, Goenaga, Miguel Ángel, del Río, Muskilda Goyeneche, Bauza, Ángela Granda, Iribarren, José Antonio, Urkola, Xabier Kortajarena, López, José Ignacio Pérez-Moreiras, Jiménez, Ainhoa Rengel, Reviejo, Karlos, Berbejillo, Alberto Sáez, Haza, Elou Sánchez, Alda, Rosa Sebastián, Ruiz, Itziar Solla, Ugartemendia, Irati Unamuno, Anza, Diego Vicente, Benito, Iñaki Villanueva, Arrieta, Mar Zabalo, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Bouzas, Alberto, Castelo, Brais, Cuenca, José, Gutiérrez, Laura, Ramos, Lucía, Mayo, María Rodríguez, Serrano, Joaquín Manuel, Regueiro, Dolores Sousa, Martínez, Francisco Javier, del Mar Alonso, Mª, Castro, Beatriz, Melian, Teresa Delgado, Sarabia, Javier Fernández, Rosado, Dácil García, González, Julia González, Lacalzada, Juan, de la Peña, Lissete Lorenzo, Ramírez, Alina Pérez, Arrondo, Pablo Prada, Moreno, Fermín Rodríguez, Ciezar, Antonio Plata, Iglesias, José Mª Reguera, Álvarez, Víctor Asensi, Costas, Carlos, de la Hera, Jesús, Suárez, Jonnathan Fernández, Fraile, Lisardo Iglesias, Arguero, Víctor León, Menéndez, José López, Bajo, Pilar Mencia, Morales, Carlos, Torrico, Alfonso Moreno, Palomo, Carmen, Martínez, Begoña Paya, Esteban, Ángeles Rodríguez, García, Raquel Rodríguez, Asensio, Mauricio Telenti, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Cuervo, Guillermo, Falces, Carlos, Fernández-Pittol, Mariana J, Fita, Guillermina, Fuster, David, de la Mària, Cristina García, García-Pares, Delia, Hernández-Meneses, Marta, Pérez, Jaume Llopis, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Roque, Mercè, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Alonso, David, Alonso, Juan Carlos, Álvarez-Uría, Ana, Bermejo, Javier, Bouza, Emilio, Caballero, Gregorio Cuerpo, Montero, Antonia Delgado, Estévez, Agustín, Ribas, Ramón Fortuny, Gargallo, Esther, Leoni, Mª Eugenia García, Mansilla, Ana González, Moraga, Francisco Javier González, Ramallo, Víctor González, Hernández, Martha Kestler, Hualde, Amaia Mari, Machado, Marina, Marín, Mercedes, Martínez-Sellés, Manuel, Melero, Rosa, Muñoz, Patricia, Monzón, Diego, Olmedo, María, Pedraz, Álvaro, Pinilla, Blanca, Pinto, Ángel, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Sánchez-Pérez, Eduardo, Segado, Antonio, Toledo, Neera, Valerio, Maricela, Vázquez, Pilar, Moreno, Eduardo Verde, de la Villa, Sofía, Antorrena, Isabel, Loeches, Belén, Moreno, Mar, Ramírez, Ulises, Bastón, Verónica Rial, Romero, María, Rosillo, Sandra, Balbín, Jesús Agüero, Fernández, Cristina Amado, Castillo, Carlos Armiñanzas, de las Revillas, Francisco Arnaiz, Belaustegui, Manuel Cobo, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Sampedro, Marta Fernández, García, Iván, Rico, Claudia González, Gutiérrez-Fernández, Laura, Gutiérrez-Cuadra, Manuel, Díez, José Gutiérrez, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Parra, Jorge Calderón, Cobo, Marta, Domínguez, Fernando, Pavía, Pablo García, Cruz, Ana Fernández, Ramos-Martínez, Antonio, Romero, Isabel Sánchez, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Stuart, Jorge Rodríguez-Roda, Ruiz, Soledad, Tenorio, Carmen Hidalgo, Sequera, Sergio, Delia, Manuel Almendro, Araji, Omar, Barquero, José Miguel, Jambrina, Román Calvo, de Cueto, Marina, Acebal, Juan Gálvez, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, Gutiérrez-Carretero, Encarnación, Lepe, José Antonio, López-Haldón, José, Luque-Márquez, Rafael, Marín, Guillermo, Ortiz-Carrellán, Antonio, Sánchez-Domínguez, Eladio, Alonso, Luis Javier, Azcárate, Pedro, Gutiérrez, José Manuel Azcona, Blanco, José Ramón, Armas, Estíbaliz Corral, García-Álvarez, Lara, Oteo, José Antonio, Membrilla, Antonio Barros, Iglesias, Antonino Ginel, Grillo, Sara, Petracca, Rubén Leta, López-Contreras, Joaquín, Martínez, María Alba Rivera, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Quiñonero, Amaia Aguirre, Miñambres, Ángela Alonso, Arana, Juan Carlos Gainzarain, de Alaiza Ortega, Sara González, Rodríguez, Miguel Ángel Morán, Rodríguez, Anai Moreno, de Zárate, Zuriñe Ortiz, Zapirain, José Joaquín Portu, de Adana Arroniz, Ester Sáez, Sánchez, Daisy Carolina Sorto, Antonio, Sánchez-Porto, Alejandro, Úbeda Iglesias, Leal, José Mª Arribas, Vázquez, Elisa García, Torres, Alicia Hernández, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Tarabini-Castellani, Paola, Gálvez, Eva Heredero, Bellido, Carolina Maicas, Pau, José Largo, Sepúlveda, Mª Antonia, Sierra, Pilar Toledano, Iqbal-Mirza, Sadaf Zafar, Alcolea, Eva Cascales, Yañez, Ivan Keituqwa, Martínez, Julián Navarro, Ballesta, Ana Peláez, Escobar, Eduardo Moreno, Monje, Alejandro Peña, Cabrera, Valme Sánchez, García, David Vinuesa, Asenjo, María Arrizabalaga, Luna, Carmen Cifuentes, Morcillo, Juana Núñez, Seco, Mª Cruz Pérez, Gelabert, Aroa Villoslada, Guallar, Carmen Aured, Abad, Nuria Fernández, Mangas, Pilar García, Adell, Marta Matamala, Ruiz, Mª Pilar Palacián, Porres, Juan Carlos, Vidal, Begoña Alcaraz, Del Amor Espín, María Jesús, Buendía, Francisco, Sánchez, Roberto Jiménez, Mármol, Rosario, Martínez, Francisco, Meseguer, Antonio, Pérez, Beatriz, Risco, Leticia, Saura, Zoser, Silva, Vanina, Villmarín, Mª Belén, Blanco, Mª Ángels Ribas, de Gopegui Bordes, Enrique Ruiz, Bonet, Laura Vidal, Borràs, Miquel Vives, Munera, Mª Carmen Bellón, Garaizabal, Elena Escribano, Martínez, Antonia Tercero, Luque, Juan Carlos Segura, Badía, Cristina, Palop, Lucía Boix, Xercavins, Mariona, Ibars, Sónia, Bosch, Xerach, Nebreda, Eloy Gómez, Herrera, Ibalia Horcajada, Gallego, Irene Menduiña, Pulido, Imanol, Santiago, Héctor Marrero, de Miguel Martínez, Isabel, Álamo, Elena Pisos, Sánchez, Daniel San Román, Pérez, Jorge Boan, Blanco, Eva Mª Aguilar, González, Mercedes Catalán, Peiretti, María Angélica Corres, Esteve, Andrea Eixerés, Pérez, Laura Domínguez, de Cossío Tejido, Santiago, Román, Francisco Galván, Robles, José Antonio García, Medrano, Francisco López, Gude, Mª Jesús López, Miguel, Mª Ángeles Orellana, Pilkington, Patrick, Ostalaza, Yolanda Revilla, Morales, Juan Ruiz, Solís, Sebastián Ruiz, Collado, Ana Sabín, Fernández, Marcos Sánchez, Rallo, Javier Solera, Martín, Jorge Solís, Escrihuela-Vidal, Francesc, Carratalà, Jordi, Grau, Inmaculada, Ardanuy, Carmen, Berbel, Dámaris, Salado, José Carlos Sánchez, Alegre, Oriol, Majoral, Alejandro Ruiz, Sbraga, Fabrizio, Blasco, Arnau, Sánchez, Laura Gracia, Sánchez-Rodríguez, Iván, Aldamiz, Gonzalo, Álvarez, Beatriz, Palacios, Marina Bernal, Úbeda, Alfonso Cabello, Roblas, Ricardo Fernández, Hernández, Rafael, Martín, Victoria Andrea Hortigüela, Kallmeyer, Andrea, Kancev, Cristina Landaeta, Martín, Marta, Ruiz, Miguel Morante, Lobato, Miguel Ángel Navas, Pello, Ana María, Prieto, Laura, Mallebrera, Marta Tomás, Varela, Laura, de la Peña Triguero, Mireia, Cerón, Ruth Esther Figueroa, Gómez, Lara Ruiz, Ble, Mireia, Gallego, Juan Pablo Horcajada, Ginel, Antonio José, López, Inmaculada, Mas, Alexandra, Mestres, Antoni, Molina, Lluís, Serrat, Ramón, Ribas, Núria, Sánchez, Francisca, Silverio, Ana, Suárez, Marina, Sorlí, Luisa, Recasens, Lluís, Taurón, Manuel, Regueras, María Fernández, Vallejo, María Ángeles Mantecón, Rivera, José Ángel Pérez, Mata, Nuria Sánchez, Cano, Antonia Calvo, Olivares, Miguel Fajardo, Núñez, María Victoria Millán, Sanz, Agustín Muñoz, Herrera-Hidalgo, Laura, Alonso-Menchén, David, Luque-Marquez, Rafael, Fariñas, María Del Carmen, Miró, Jose Maria, Goenaga, Miguel Angel, Angulo-Lara, Basilio, and Boix-Palop, Lucia

Published
2023
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6. Susceptibility and transmissibility of SARS-CoV-2 variants in transgenic mice expressing the cat angiotensin-converting enzyme 2 (ACE-2) receptor

Author

Fundación BBVA, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Jiménez de Oya, Nereida [0000-0003-3129-813X], Calvo Pinilla, Eva María [0000-0002-4667-4081], Mingo-Casas, Patricia [0000-0003-1207-240X], Escribano-Romero, Estela [0000-0002-5036-7607], Blázquez, Ana B. [0000-0002-0847-0977], Fernández González, Raúl [0000-0003-1989-2945], Pericuesta Camacho, Eva [0000-0001-9387-3270], Sánchez-Cordón, P. J. [0000-0002-2407-6259], Martín-Acebes, M. A. [0000-0001-6015-3613], Gutiérrez-Adán, Alfonso [0000-0001-9893-9179], Saiz Calahorra, Juan Carlos [0000-0001-8269-5544], Jiménez de Oya, Nereida, Calvo Pinilla, Eva María, Mingo-Casas, Patricia, Escribano-Romero, Estela, Blázquez, Ana B., Esteban, Ana, Fernández González, Raúl, Pericuesta Camacho, Eva, Sánchez-Cordón, P. J., Martín-Acebes, M. A., Gutiérrez-Adán, Alfonso, Saiz Calahorra, Juan Carlos, Fundación BBVA, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Jiménez de Oya, Nereida [0000-0003-3129-813X], Calvo Pinilla, Eva María [0000-0002-4667-4081], Mingo-Casas, Patricia [0000-0003-1207-240X], Escribano-Romero, Estela [0000-0002-5036-7607], Blázquez, Ana B. [0000-0002-0847-0977], Fernández González, Raúl [0000-0003-1989-2945], Pericuesta Camacho, Eva [0000-0001-9387-3270], Sánchez-Cordón, P. J. [0000-0002-2407-6259], Martín-Acebes, M. A. [0000-0001-6015-3613], Gutiérrez-Adán, Alfonso [0000-0001-9893-9179], Saiz Calahorra, Juan Carlos [0000-0001-8269-5544], Jiménez de Oya, Nereida, Calvo Pinilla, Eva María, Mingo-Casas, Patricia, Escribano-Romero, Estela, Blázquez, Ana B., Esteban, Ana, Fernández González, Raúl, Pericuesta Camacho, Eva, Sánchez-Cordón, P. J., Martín-Acebes, M. A., Gutiérrez-Adán, Alfonso, and Saiz Calahorra, Juan Carlos

Abstract

The emergence of SARS-CoV-2 in 2019 and its rapid spread throughout the world has caused the largest pandemic of our modern era. The zoonotic origin of this pathogen highlights the importance of the One Health concept and the need for a coordinated response to this kind of threats. Since its emergence, the virus has caused >7 million deaths worldwide. However, the animal source for human outbreaks remains unknown. The ability of the virus to jump between hosts is facilitated by the presence of the virus receptor, the highly conserved angiotensin-converting enzyme 2 (ACE2), found in various mammals. Positivity for SARS-CoV-2 has been reported in various species, including domestic animals and livestock, but their potential role in bridging viral transmission to humans is still unknown. Additionally, the virus has evolved over the pandemic, resulting in variants with different impacts on human health. Therefore, suitable animal models are crucial to evaluate the susceptibility of different mammalian species to this pathogen and the adaptability of different variants. In this work, we established a transgenic mouse model that expresses the feline ACE2 protein receptor (cACE2) under the human cytokeratin 18 (K18) gene promoter's control, enabling high expression in epithelial cells, which the virus targets. Using this model, we assessed the susceptibility, pathogenicity, and transmission of SARS-CoV-2 variants. Our results show that the sole expression of the cACE2 receptor in these mice makes them susceptible to SARS-CoV-2 variants from the initial pandemic wave but does not enhance susceptibility to omicron variants. Furthermore, we demonstrated efficient contact transmission of SARS-CoV-2 between transgenic mice that express either the feline or the human ACE2 receptor.

Published
2024

13. Allergy to kiwi: a double-blind, placebo-controlled food challenge study in patients from a birch-free area.

Author

Alemán, Ana, Sastre, Joaquín, Quirce, Santiago, Heras González, Manuel De Las, Carnés, Jerónimo, Fernández-Caldas, Enrique, Pastor Vargas, Carlos, Blázquez, Ana Belén, Vivanco Martínez, Fernando, Cuesta-Herranz, Javier, Alemán, Ana, Sastre, Joaquín, Quirce, Santiago, Heras González, Manuel De Las, Carnés, Jerónimo, Fernández-Caldas, Enrique, Pastor Vargas, Carlos, Blázquez, Ana Belén, Vivanco Martínez, Fernando, and Cuesta-Herranz, Javier

Abstract

ackground: Allergy to kiwi fruit is being increasingly reported, but it has never been evaluated by means of a double-blind, placebo-controlled food challenge (DBPCFC) study. Objective: We sought to assess kiwi allergy on the basis of a DBPCFC and identify the patterns of allergen recognition in sensitized patients from a birch-free area. Methods: Forty-three patients with allergy symptoms who were sensitized to kiwi were evaluated by means of clinical history, skin tests, IgE determinations, and DBPCFCs. The pattern of allergen recognition was assessed by means of IgE immunoblotting. Sequence analysis of IgE-binding bands was performed by using Edman degradation. Results: DBPCFCs were performed in 33 patients; 4 patients had experienced severe anaphylaxis, and 6 patients declined informed consent. DBPCFC results were positive in 23 patients and negative in 10 patients. The most frequent clinical manifestation was oral allergy syndrome. Twenty-one percent of the patients were not allergic to pollen. Forty-six percent of patients experienced systemic symptoms, and this happened with higher frequency in patients not allergic to pollen (100%). Twenty-eight percent of the patients were sensitized to latex. The IgE-binding bands in kiwi extract more frequently recognized by patient sera were those of 30, 24, 66, and 12 kd, and they could not be associated with any pattern of kiwi-induced allergic reactions. Conclusion: The results provide evidence that kiwi allergy is not a homogeneous disorder because several clinical subgroups can be established. No definite allergen-recognition pattern was associated with the type of allergic reactions to kiwi. One of 5 patients with kiwi allergy was not allergic to pollen, and these patients had the highest risk of systemic reactions to kiwi., Depto. de Bioquímica y Biología Molecular, Fac. de Ciencias Químicas, TRUE, pub

Published
2024

14. Serine 132 Is the C3 Covalent Attachment Point on the CH1 Domain of Human IgG1

Author

Vidarte, Luis, Pastor Vargas, Carlos, Mas, Sebastian, Blázquez, Ana Belen, Rios, Vivian de los, Guerrero, Rosa, Vivanco Martínez, Fernando, Vidarte, Luis, Pastor Vargas, Carlos, Mas, Sebastian, Blázquez, Ana Belen, Rios, Vivian de los, Guerrero, Rosa, and Vivanco Martínez, Fernando

Abstract

The covalent binding of C3 (complement component C3) to antigen-antibody complexes (Ag.Ab; immune complexes (ICs)) is a key event in the uptake, transport, presentation, and elimination of Ag in the form of Ag.Ab.C3b (IC.C3b). Upon interaction of C3 with IgG.IC, C3b.C3b.IgG covalent complexes are formed that are detected on SDS-polyacrylamide gel electrophoresis by two bands corresponding to C3b.C3b (band A) and C3b.IgG (band B) covalent complexes. This allows one to evaluate the covalent binding of C3b to IgG antibodies. It has been described that C3b can attach to both the Fab (on the CH1 domain) and the Fc regions of IgG. Here the covalent interaction of C3b to the CH1 domain, a region previously described spanning residues 125-147, has been studied. This region of the CH1 domain is exposed to solvent and contains a cluster of six potential acceptor sites for ester bond formation with C3b (four Ser and two Thr). A set of 10 mutant Abs were generated with the putative acceptor residues substituted by Ala, and we studied their covalent interaction with C3b. Single (Ser-131, Ser-132, Ser-134, Thr-135, Ser-136, and Thr-139), double (positions 131-132), and multiple (positions 134-135-136, 131-132-134-135-136, and 131-132-134-135-136-139) mutants were produced. None of the mutants (single, double, or multiple) abolished completely the ability of IgG to bind C3b, indicating the presence of C3b binding regions other than in the CH1 domain. However, all mutant Abs, in which serine at position 132 was replaced by Ala, showed a significant decrease in the ability to form C3b.IgG covalent complexes, whereas the remaining mutants had normal activity. In addition we examined ICs using the F(ab')2 fragment of the mutant Abs, and only those containing Ala at position 132 (instead of Ser) failed to bind C3b. Thus Ser-132 is the binding site for C3b on the CH1 domain of the heavy chain, in the Fab region of human IgG., Depto. de Bioquímica y Biología Molecular, Fac. de Ciencias Químicas, TRUE, pub

Published
2024

16. Eribulin in metastatic breast cancer: Real world data

Author

Fernández-Laguna, Clara Luz, primary, Maray, Ivan, additional, Macia-Rivas, Lola, additional, Álvarez-Asteinza, Cristina, additional, Fernández-Lastras, Sergio, additional, Velasco Durántez, Veronica, additional, Carbajales Álvarez, Mónica, additional, and Lozan-Blázquez, Ana, additional

Published
2023
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17. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Author

Herrera-Hidalgo, Laura, primary, Muñoz, Patricia, additional, Álvarez-Uría, Ana, additional, Alonso-Menchén, David, additional, Luque-Marquez, Rafael, additional, Gutiérrez-Carretero, Encarnación, additional, Fariñas, María Del Carmen, additional, Miró, Jose Maria, additional, Goenaga, Miguel Angel, additional, López-Cortés, Luis Eduardo, additional, Angulo-Lara, Basilio, additional, Boix-Palop, Lucia, additional, de Alarcón, Arístides, additional, Sánchez, Fernando Fernández, additional, de Lomas, José Mª García, additional, Rosas, Gabriel, additional, de la Torre Lima, Javier, additional, Bereciartua, Elena, additional, Vidal, María José Blanco, additional, Blanco, Roberto, additional, Boado, María Victoria, additional, Lázaro, Marta Campaña, additional, Crespo, Alejandro, additional, Carrión, Laura Guio, additional, Del Álamo Martínez de Lagos, Mikel, additional, Ugarte, Gorane Euba, additional, Goikoetxea, Ane Josune, additional, Hierro, Marta Ibarrola, additional, Iruretagoyena, José Ramón, additional, Zuazabal, Josu Irurzun, additional, López-Soria, Leire, additional, Montejo, Miguel, additional, Nieto, Javier, additional, Rodrigo, David, additional, Rodríguez, Regino, additional, Vitoria, Yolanda, additional, Voces, Roberto, additional, López, Mª Victoria García, additional, Georgieva, Radka Ivanova, additional, Ojeda, Guillermo, additional, Bailón, Isabel Rodríguez, additional, Morales, Josefa Ruiz, additional, Rodríguez, Ignacio Álvarez, additional, Galparsoro, Harkaitz Azkune, additional, Boronat, Elisa Berritu, additional, Odriozola, Mª Jesús Bustinduy, additional, del Bosque Martín, Cristina, additional, Echeverría, Tomás, additional, Yarza, Alberto Eizaguirre, additional, Fuentes, Ana, additional, Goenaga, Miguel Ángel, additional, del Río, Muskilda Goyeneche, additional, Bauza, Ángela Granda, additional, Iribarren, José Antonio, additional, Urkola, Xabier Kortajarena, additional, López, José Ignacio Pérez-Moreiras, additional, Jiménez, Ainhoa Rengel, additional, Reviejo, Karlos, additional, Berbejillo, Alberto Sáez, additional, Haza, Elou Sánchez, additional, Alda, Rosa Sebastián, additional, Ruiz, Itziar Solla, additional, Ugartemendia, Irati Unamuno, additional, Anza, Diego Vicente, additional, Benito, Iñaki Villanueva, additional, Arrieta, Mar Zabalo, additional, Carrasco, Rafael, additional, Climent, Vicente, additional, Llamas, Patricio, additional, Merino, Esperanza, additional, Plazas, Joaquín, additional, Reus, Sergio, additional, Bouzas, Alberto, additional, Castelo, Brais, additional, Cuenca, José, additional, Gutiérrez, Laura, additional, Ramos, Lucía, additional, Mayo, María Rodríguez, additional, Serrano, Joaquín Manuel, additional, Regueiro, Dolores Sousa, additional, Martínez, Francisco Javier, additional, del Mar Alonso, Mª, additional, Castro, Beatriz, additional, Melian, Teresa Delgado, additional, Sarabia, Javier Fernández, additional, Rosado, Dácil García, additional, González, Julia González, additional, Lacalzada, Juan, additional, de la Peña, Lissete Lorenzo, additional, Ramírez, Alina Pérez, additional, Arrondo, Pablo Prada, additional, Moreno, Fermín Rodríguez, additional, Ciezar, Antonio Plata, additional, Iglesias, José Mª Reguera, additional, Álvarez, Víctor Asensi, additional, Costas, Carlos, additional, de la Hera, Jesús, additional, Suárez, Jonnathan Fernández, additional, Fraile, Lisardo Iglesias, additional, Arguero, Víctor León, additional, Menéndez, José López, additional, Bajo, Pilar Mencia, additional, Morales, Carlos, additional, Torrico, Alfonso Moreno, additional, Palomo, Carmen, additional, Martínez, Begoña Paya, additional, Esteban, Ángeles Rodríguez, additional, García, Raquel Rodríguez, additional, Asensio, Mauricio Telenti, additional, Almela, Manuel, additional, Ambrosioni, Juan, additional, Azqueta, Manuel, additional, Brunet, Mercè, additional, Bodro, Marta, additional, Cartañá, Ramón, additional, Cuervo, Guillermo, additional, Falces, Carlos, additional, Fernández-Pittol, Mariana J, additional, Fita, Guillermina, additional, Fuster, David, additional, de la Mària, Cristina García, additional, García-Pares, Delia, additional, Hernández-Meneses, Marta, additional, Pérez, Jaume Llopis, additional, Marco, Francesc, additional, Miró, José M., additional, Moreno, Asunción, additional, Nicolás, David, additional, Ninot, Salvador, additional, Quintana, Eduardo, additional, Paré, Carlos, additional, Pereda, Daniel, additional, Pericás, Juan M., additional, Pomar, José L., additional, Ramírez, José, additional, Roque, Mercè, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Soy, Dolors, additional, Téllez, Adrián, additional, Tolosana, José M., additional, Vidal, Bárbara, additional, Vila, Jordi, additional, Adán, Iván, additional, Alonso, David, additional, Alonso, Juan Carlos, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Caballero, Gregorio Cuerpo, additional, Montero, Antonia Delgado, additional, Estévez, Agustín, additional, Ribas, Ramón Fortuny, additional, Gargallo, Esther, additional, Leoni, Mª Eugenia García, additional, Mansilla, Ana González, additional, Moraga, Francisco Javier González, additional, Ramallo, Víctor González, additional, Hernández, Martha Kestler, additional, Hualde, Amaia Mari, additional, Machado, Marina, additional, Marín, Mercedes, additional, Martínez-Sellés, Manuel, additional, Melero, Rosa, additional, Monzón, Diego, additional, Olmedo, María, additional, Pedraz, Álvaro, additional, Pinilla, Blanca, additional, Pinto, Ángel, additional, Rincón, Cristina, additional, Rodríguez-Abella, Hugo, additional, Rodríguez-Créixems, Marta, additional, Sánchez-Pérez, Eduardo, additional, Segado, Antonio, additional, Toledo, Neera, additional, Valerio, Maricela, additional, Vázquez, Pilar, additional, Moreno, Eduardo Verde, additional, de la Villa, Sofía, additional, Antorrena, Isabel, additional, Loeches, Belén, additional, Moreno, Mar, additional, Ramírez, Ulises, additional, Bastón, Verónica Rial, additional, Romero, María, additional, Rosillo, Sandra, additional, Balbín, Jesús Agüero, additional, Fernández, Cristina Amado, additional, Castillo, Carlos Armiñanzas, additional, de las Revillas, Francisco Arnaiz, additional, Belaustegui, Manuel Cobo, additional, Fariñas, María Carmen, additional, Fariñas-Álvarez, Concepción, additional, Sampedro, Marta Fernández, additional, García, Iván, additional, Rico, Claudia González, additional, Gutiérrez-Fernández, Laura, additional, Gutiérrez-Cuadra, Manuel, additional, Díez, José Gutiérrez, additional, Pajarón, Marcos, additional, Parra, José Antonio, additional, Teira, Ramón, additional, Zarauza, Jesús, additional, Parra, Jorge Calderón, additional, Cobo, Marta, additional, Domínguez, Fernando, additional, Pavía, Pablo García, additional, Cruz, Ana Fernández, additional, Ramos-Martínez, Antonio, additional, Romero, Isabel Sánchez, additional, Centella, Tomasa, additional, Hermida, José Manuel, additional, Moya, José Luis, additional, Martín-Dávila, Pilar, additional, Navas, Enrique, additional, Oliva, Enrique, additional, del Río, Alejandro, additional, Stuart, Jorge Rodríguez-Roda, additional, Ruiz, Soledad, additional, Tenorio, Carmen Hidalgo, additional, Sequera, Sergio, additional, Delia, Manuel Almendro, additional, Araji, Omar, additional, Barquero, José Miguel, additional, Jambrina, Román Calvo, additional, de Cueto, Marina, additional, Acebal, Juan Gálvez, additional, Méndez, Irene, additional, Morales, Isabel, additional, Lepe, José Antonio, additional, López-Haldón, José, additional, Luque-Márquez, Rafael, additional, Marín, Guillermo, additional, Ortiz-Carrellán, Antonio, additional, Sánchez-Domínguez, Eladio, additional, Alonso, Luis Javier, additional, Azcárate, Pedro, additional, Gutiérrez, José Manuel Azcona, additional, Blanco, José Ramón, additional, Armas, Estíbaliz Corral, additional, García-Álvarez, Lara, additional, Oteo, José Antonio, additional, Membrilla, Antonio Barros, additional, Iglesias, Antonino Ginel, additional, Grillo, Sara, additional, Petracca, Rubén Leta, additional, López-Contreras, Joaquín, additional, Martínez, María Alba Rivera, additional, Álvarez, M., additional, Fernández, A.L., additional, Martínez, Amparo, additional, Prieto, A., additional, Regueiro, Benito, additional, Tijeira, E., additional, Vega, Marino, additional, Quiñonero, Amaia Aguirre, additional, Miñambres, Ángela Alonso, additional, Arana, Juan Carlos Gainzarain, additional, de Alaiza Ortega, Sara González, additional, Rodríguez, Miguel Ángel Morán, additional, Rodríguez, Anai Moreno, additional, de Zárate, Zuriñe Ortiz, additional, Zapirain, José Joaquín Portu, additional, de Adana Arroniz, Ester Sáez, additional, Sánchez, Daisy Carolina Sorto, additional, Antonio, Sánchez-Porto, additional, Alejandro, Úbeda Iglesias, additional, Leal, José Mª Arribas, additional, Vázquez, Elisa García, additional, Torres, Alicia Hernández, additional, Blázquez, Ana, additional, de la Morena Valenzuela, Gonzalo, additional, Alonso, Ángel, additional, Aramburu, Javier, additional, Calvo, Felicitas Elena, additional, Tarabini-Castellani, Paola, additional, Gálvez, Eva Heredero, additional, Bellido, Carolina Maicas, additional, Pau, José Largo, additional, Sepúlveda, Mª Antonia, additional, Sierra, Pilar Toledano, additional, Iqbal-Mirza, Sadaf Zafar, additional, Alcolea, Eva Cascales, additional, Yañez, Ivan Keituqwa, additional, Martínez, Julián Navarro, additional, Ballesta, Ana Peláez, additional, Escobar, Eduardo Moreno, additional, Monje, Alejandro Peña, additional, Cabrera, Valme Sánchez, additional, García, David Vinuesa, additional, Asenjo, María Arrizabalaga, additional, Luna, Carmen Cifuentes, additional, Morcillo, Juana Núñez, additional, Seco, Mª Cruz Pérez, additional, Gelabert, Aroa Villoslada, additional, Guallar, Carmen Aured, additional, Abad, Nuria Fernández, additional, Mangas, Pilar García, additional, Adell, Marta Matamala, additional, Ruiz, Mª Pilar Palacián, additional, Porres, Juan Carlos, additional, Vidal, Begoña Alcaraz, additional, Del Amor Espín, María Jesús, additional, Buendía, Francisco, additional, Sánchez, Roberto Jiménez, additional, Mármol, Rosario, additional, Martínez, Francisco, additional, Meseguer, Antonio, additional, Pérez, Beatriz, additional, Risco, Leticia, additional, Saura, Zoser, additional, Silva, Vanina, additional, Villmarín, Mª Belén, additional, Blanco, Mª Ángels Ribas, additional, de Gopegui Bordes, Enrique Ruiz, additional, Bonet, Laura Vidal, additional, Borràs, Miquel Vives, additional, Munera, Mª Carmen Bellón, additional, Garaizabal, Elena Escribano, additional, Martínez, Antonia Tercero, additional, Luque, Juan Carlos Segura, additional, Badía, Cristina, additional, Palop, Lucía Boix, additional, Xercavins, Mariona, additional, Ibars, Sónia, additional, Bosch, Xerach, additional, Nebreda, Eloy Gómez, additional, Herrera, Ibalia Horcajada, additional, Gallego, Irene Menduiña, additional, Pulido, Imanol, additional, Santiago, Héctor Marrero, additional, de Miguel Martínez, Isabel, additional, Álamo, Elena Pisos, additional, Sánchez, Daniel San Román, additional, Pérez, Jorge Boan, additional, Blanco, Eva Mª Aguilar, additional, González, Mercedes Catalán, additional, Peiretti, María Angélica Corres, additional, Esteve, Andrea Eixerés, additional, Pérez, Laura Domínguez, additional, de Cossío Tejido, Santiago, additional, Román, Francisco Galván, additional, Robles, José Antonio García, additional, Medrano, Francisco López, additional, Gude, Mª Jesús López, additional, Miguel, Mª Ángeles Orellana, additional, Pilkington, Patrick, additional, Ostalaza, Yolanda Revilla, additional, Morales, Juan Ruiz, additional, Solís, Sebastián Ruiz, additional, Collado, Ana Sabín, additional, Fernández, Marcos Sánchez, additional, Rallo, Javier Solera, additional, Martín, Jorge Solís, additional, Escrihuela-Vidal, Francesc, additional, Carratalà, Jordi, additional, Grau, Inmaculada, additional, Ardanuy, Carmen, additional, Berbel, Dámaris, additional, Salado, José Carlos Sánchez, additional, Alegre, Oriol, additional, Majoral, Alejandro Ruiz, additional, Sbraga, Fabrizio, additional, Blasco, Arnau, additional, Sánchez, Laura Gracia, additional, Sánchez-Rodríguez, Iván, additional, Aldamiz, Gonzalo, additional, Álvarez, Beatriz, additional, Palacios, Marina Bernal, additional, Úbeda, Alfonso Cabello, additional, Roblas, Ricardo Fernández, additional, Hernández, Rafael, additional, Martín, Victoria Andrea Hortigüela, additional, Kallmeyer, Andrea, additional, Kancev, Cristina Landaeta, additional, Martín, Marta, additional, Ruiz, Miguel Morante, additional, Lobato, Miguel Ángel Navas, additional, Pello, Ana María, additional, Prieto, Laura, additional, Mallebrera, Marta Tomás, additional, Varela, Laura, additional, de la Peña Triguero, Mireia, additional, Cerón, Ruth Esther Figueroa, additional, Gómez, Lara Ruiz, additional, Ble, Mireia, additional, Gallego, Juan Pablo Horcajada, additional, Ginel, Antonio José, additional, López, Inmaculada, additional, Mas, Alexandra, additional, Mestres, Antoni, additional, Molina, Lluís, additional, Serrat, Ramón, additional, Ribas, Núria, additional, Sánchez, Francisca, additional, Silverio, Ana, additional, Suárez, Marina, additional, Sorlí, Luisa, additional, Recasens, Lluís, additional, Taurón, Manuel, additional, Regueras, María Fernández, additional, Vallejo, María Ángeles Mantecón, additional, Rivera, José Ángel Pérez, additional, Mata, Nuria Sánchez, additional, Cano, Antonia Calvo, additional, Olivares, Miguel Fajardo, additional, Núñez, María Victoria Millán, additional, and Sanz, Agustín Muñoz, additional

Published
2023
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19. Mechanisms of Infection in Zika Virus

Author

Blázquez, Ana B. [0000-0002-0847-0977], Blázquez, Ana B., Blázquez, Ana B. [0000-0002-0847-0977], and Blázquez, Ana B.

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus that was first identified in Uganda in 1947, then was essentially neglected for six decades. However, in 2007, a ZIKV outbreak emerged in the Western Pacific Ocean, and between 2013 and 2014, a larger outbreak spread in the South Pacific, reaching South America in 2015 [1]. In 2016, the World Health Organization (WHO) declared a Public Health Emergency of International Concern. Even though the virus is transmitted by mosquitoes, mainly of the genus Aedes (Stegomyia), other transmission routes have been reported: between sexual partners and from mother to fetus, as well as via the transfusion of blood and blood products [2].

Published
2023

20. Dysregulation in host sphingolipid metabolism caused by West Nile virus infection as a potential disease progression biomarker and new therapeutic target

Author

European Commission, Mingo-Casas, Patricia [0000-0003-1207-240X], Sanchez-Céspedes, Javier [0000-0003-2707-1979], Blázquez, Ana B. [0000-0002-0847-0977], Casas, Josefina [0000-0002-7926-5209], Balsera-Manzanero, María [0000-0001-5667-925X], Herrero, Laura [0000-0003-4244-4673], Pachón, Jerónimo [0000-0002-8166-5308], Aguilar-Guisado, Manuela [0000-0001-5639-9434], Mingo-Casas, Patricia, Sanchez-Céspedes, Javier, Blázquez, Ana B., Casas, Josefina, Balsera-Manzanero, María, Herrero, Laura, Vázquez, Ana, Pachón, Jerónimo, Aguilar-Guisado, Manuela, European Commission, Mingo-Casas, Patricia [0000-0003-1207-240X], Sanchez-Céspedes, Javier [0000-0003-2707-1979], Blázquez, Ana B. [0000-0002-0847-0977], Casas, Josefina [0000-0002-7926-5209], Balsera-Manzanero, María [0000-0001-5667-925X], Herrero, Laura [0000-0003-4244-4673], Pachón, Jerónimo [0000-0002-8166-5308], Aguilar-Guisado, Manuela [0000-0001-5639-9434], Mingo-Casas, Patricia, Sanchez-Céspedes, Javier, Blázquez, Ana B., Casas, Josefina, Balsera-Manzanero, María, Herrero, Laura, Vázquez, Ana, Pachón, Jerónimo, and Aguilar-Guisado, Manuela

Abstract

West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bites of infected Culex sp mosquitoes and it is widely distributed across Europe. Severe forms of West Nile disease (WND) can cause meningitis, encephalitis or even death. In 2020, WNV caused an outbreak in southwest Spain that ended up with 70 human infections and 7 deaths. There are no vaccines or specific drugs to prevent and treat the symptoms of WND in humans, so the search for novel targets for therapeutic interventions is mandatory. Lipid metabolism is gaining interest as a potential target to combat flavivirus using a host-targeted approach.

Published
2023

21. Role of age and comorbidities in mortality of patients with infective endocarditis

Author

Armiñanzas, Carlos, Fariñas-Alvarez, Concepción, Zarauza, Jesús, Muñoz, Patricia, González Ramallo, Víctor, Martínez Sellés, Manuel, Miró Meda, José Mª., Pericás, Juan Manuel, Goenaga, Miguel Ángel, Ojeda Burgos, Guillermo, Rodríguez Álvarez, Regino, Castelo Corral, Laura, Gálvez-Acebal, Juan, Martínez Marcos, Francisco Javier, Fariñas, Maria Carmen, Fernández Sánchez, Fernando, Noureddine, Mariam, Rosas, Gabriel, de la Torre Lima, Javier, Aramendi, José, Bereciartua, Elena, Blanco, María José, Blanco, Roberto, Boado, María Victoria, Campaña Lázaro, Marta, Crespo, Alejandro, Goikoetxea, Josune, Iruretagoyena, José Ramón, Irurzun Zuazabal, Josu, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García López, Mª. Victoria, Georgieva, Radka Ivanova, Ojeda, Guillermo, Rodríguez Bailón, Isabel, Ruiz Morales, Josefa, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Idígoras, Pedro, Iribarren, José Antonio, Izaguirre Yarza, Alberto, Kortajarena Urkola, Xabier, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Miguez Rey, Enrique, Rodríguez Mayo, María, Sánchez, Efrén, Sousa Regueiro, Dolores, Martínez, Francisco Javier, Alonso, Mª. del Mar, Castro, Beatriz, García Rosado, Dácil, Durán, Mª. del Carmen, Miguel Gómez, Mª. Antonia, Lacalzada, Juan, Nassar, Ibrahim, Plata Ciezar, Antonio, Reguera Iglesias, José Mª., Asensi Álvarez, Víctor, Costas, Carlos, de la Hera, Jesús, Fernández Suárez, Jonnathan, Iglesias Fraile, Lisardo, León Arguero, Víctor, López Menéndez, José, Mencia Bajo, Pilar, Morales, Carlos, Moreno Torrico, Alfonso, Palomo, Carmen, Paya Martínez, Begoña, Rodríguez Esteban, Ángeles, Rodríguez García, Raquel, Telenti Asensio, Mauricio, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Llopis Pérez, Jaume, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Celemín, Daniel, Cuerpo Caballero, Gregorio, Delgado Montero, Antonia, Fernández Cruz, Ana, García Mansilla, Ana, García Leoni, Mª. Eugenia, Kestler Hernández, Martha, Hualde, Amaia Mari, Marín, Mercedes, Martínez-Sellés, Manuel, Menárguez, Mª. Cruz, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Verde Moreno, Eduardo, Antorrena, Isabel, Loeches, Belén, Martín Quirós, Alejandro, Moreno, Mar, Ramírez, Ulises, Rial Bastón, Verónica, Romero, María, Saldaña, Araceli, Agüero Balbín, Jesús, Amado, Cristina, Armiñanzas Castillo, Carlos, Arnaiz García, Ana, Cobo Belaustegui, Manuel, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Gómez Izquierdo, Rubén, García, Iván, González-Rico, Claudia, Gutiérrez-Cuadra, Manuel, Gutiérrez Díez, José, Pajarón, Marcos, Parra, José Antonio, Sarralde, Aurelio, Teira, Ramón, Domínguez, Fernando, García Pavía, Pablo, González, Jesús, Orden, Beatriz, Ramos, Antonio, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Ruiz, Soledad, Hidalgo Tenorio, Carmen, Almendro Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo Jambrina, Román, de Cueto, Marina, Gálvez Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Canut Blasco, Andrés, Cordo Mollar, José, Gainzarain Arana, Juan Carlos, García Uriarte, Oscar, Martín López, Alejandro, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, García Domínguez, Gloria, Sánchez-Porto, Antonio, Arribas Leal, José Mª., García Vázquez, Elisa, Hernández Torres, Alicia, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Moreno Rodríguez, Anai, Tarabini-Castellani, Paola, Heredero Gálvez, Eva, Maicas Bellido, Carolina, Largo Pau, José, Sepúlveda, Mª. Antonia, Toledano Sierra, Pilar, Iqbal-Mirza, Sadaf Zafar, Cascales Alcolea, Eva, Egea Serrano, Pilar, Hernández Roca, José Joaquín, Keituqwa Yañez, Ivan, Peláez Ballesta, Ana, Soriano, Víctor, Moreno Escobar, Eduardo, Peña Monje, Alejandro, Sánchez Cabrera, Valme, Vinuesa García, David, Arrizabalaga Asenjo, María, Cifuentes Luna, Carmen, Núñez Morcillo, Juana, Pérez Seco, Mª. Cruz, Villoslada Gelabert, Aroa, Aured Guallar, Carmen, Fernández Abad, Nuria, García Mangas, Pilar, Matamala Adell, Marta, Palacián Ruiz, Mª. Pilar, Porres, Juan Carlos, Alcaraz Vidal, Begoña, Cobos Trigueros, Nazaret, Del Amor Espín, María Jesús, Giner Caro, José Antonio, Jiménez Sánchez, Roberto, Jimeno Almazán, Amaya, Ortín Freire, Alejandro, Viqueira González, Monserrat, Pericás Ramis, Pere, Ribas Blanco, Mª. Ángels, Ruiz de Gopegui Bordes, Enrique, Vidal Bonet, Laura, Bellón Munera, Mª. Carmen, Escribano Garaizabal, Elena, Tercero Martínez, Antonia, and Segura Luque, Juan Carlos

Published
2019
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23. UN ICONO PARA LA MONARQUÍA HISPANA: EL TRATAMIENTO DE HERMENEGILDO EN LA CRÓNICA GENERAL DE ESPAÑA DE AMBROSIO DE MORALES.

Author

Mihi Blázquez, Ana María

Subjects
INSPIRATION, MONARCHY, PRINCES, CATHOLICS, HISTORIOGRAPHY
Abstract

Copyright of Librosdelacorte.es is the property of Instituto Universitario "La Corte en Europa" - IULCE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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25. Digital health

Author

van der Schors, Tjalling, primary, Lozano-Blázquez, Ana, additional, Kuruc Poje, Darija, additional, Miljković, Nenad, additional, Süle, András, additional, and Kohl, Stephanie, additional

Published
2023
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27. Gentamicin may have no effect on mortality of staphylococcal prosthetic valve endocarditis

Author

Sánchez, Fernando Fernández, Noureddine, Mariam, Rosas, Gabriel, Lima, Javier de la Torre, Aramendi, José, Bereciartua, Elena, Blanco, Roberto, Boado, María Victoria, Estébanez, Itxasne Cabezón, Lázaro, Marta Campaña, Goikoetxea, Josune, Goiti, Juan José, Iruretagoyena, José Ramón, Zuazabal, Josu Irurzun, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodríguez, David, Rodríguez, Regino, Voces, Roberto, López, M<ce:sup loc='post">a</ce:sup> Victoria García, Georgieva, Radka Ivanova, Ojeda, Guillermo, Bailón, Isabel Rodríguez, Morales, Josefa Ruiz, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Goenaga, Miguel Ángel, Idígoras, Pedro, Iribarren, José Antonio, Yarza, Alberto Izaguirre, Urkola, Xabier Kortajarena, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Rey, Enrique Miguez, Mayo, María Rodríguez, Sánchez, Efrén, Regueiro, Dolores Sousa, Martínez, Francisco Javier, del Mar Alonso, M<ce:sup loc='post">a</ce:sup>, Castro, Beatriz, Rosado, Dácil García, del Carmen Durán, M<ce:sup loc='post">a</ce:sup>, Antonia Miguel Gómez, M<ce:sup loc='post">a</ce:sup>, Lacalzada, Juan, Nassar, Ibrahim, Ciezar, Antonio Plata, Reguera Iglesias, José M<ce:sup loc='post">a</ce:sup>, Álvarez, Víctor Asensi, Costas, Carlos, Hera, Jesús de la, Suárez, Jonnathan Fernández, Fraile, Lisardo Iglesias, Arguero, Víctor León, Menéndez, José López, Bajo, Pilar Mencia, Morales, Carlos, Torrico, Alfonso Moreno, Palomo, Carmen, Martínez, Begoña Paya, Esteban, Ángeles Rodríguez, García, Raquel Rodríguez, Asensio, Mauricio Telenti, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Pérez, Jaume Llopis, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Caballero, Gregorio Cuerpo, Cruz, Ana Fernández, García Leoni, M<ce:sup loc='post">a</ce:sup> Eugenia, Ramallo, Víctor González, Hernández, Martha Kestler, Marín, Mercedes, Martínez-Sellés, Manuel, Menárguez, M<ce:sup loc='post">a</ce:sup> Cruz, Muñoz, Patricia, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Moreno, Eduardo Verde, Antorrena, Isabel, Loeches, Belén, Quirós, Alejandro Martín, Moreno, Mar, Ramírez, Ulises, Bastón, Verónica Rial, Romero, María, Saldaña, Araceli, Balbín, Jesús Agüero, Castillo, Carlos Armiñanzas, Arnaiz, Ana, Arnaiz de las Revillas, Francisco, Belaustegui, Manuel Cobo, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Izquierdo, Rubén Gómez, García, Iván, Rico, Claudia González, Gutiérrez-Cuadra, Manuel, Díez, José Gutiérrez, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Domínguez, Fernando, Pavíaz, Pablo García, Gonzálezz, Jesús, Ordenz, Beatriz, Ramosz, Antonio, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, Río, Alejandro del, Ruiz, Soledad, Tenorio, Carmen Hidalgo, Delia, Manuel Almendro, Araji, Omar, Barquero, José Miguel, Jambrina, Román Calvo, de Cueto, Marina, Acebal, Juan Gálvez, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Blasco, Andrés Canut, Mollar, José Cordo, Gainzarain Arana, Juan Carlos, Uriarte, Oscar García, López, Alejandro Martín, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, Domínguez, Gloria García, Sánchez-Porto, Antonio, Arribas Leal, José M<ce:sup loc='post">a</ce:sup>, Vázquez, Elisa García, Torres, Alicia Hernández, Blázquez, Ana, Valenzuela, Gonzalo de la Morena, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Rodríguez, Anai Moreno, Tarabini-Castellani, Paola, Gálvez, Eva Heredero, Bellido, Carolina Maicas, Pau, José Largo, Sepúlveda, M<ce:sup loc='post">a</ce:sup> Antonia, Sierra, Pilar Toledano, Iqbal-Mirza, Sadaf Zafar, Alcolea, Eva Cascales, Serrano, Pilar Egea, Hernández Roca, José Joaquín, Yañez, Ivan Keituqwa, Ballesta, Ana Peláez, Soriano, Víctor, Escobar, Eduardo Moreno, Monje, Alejandro Peña, Cabrera, Valme Sánchez, García, David Vinuesa, Asenjo, María Arrizabalaga, Luna, Carmen Cifuentes, Morcillo, Juana Núñez, Pérez Seco, M<ce:sup loc='post">a</ce:sup> Cruz, Gelabert, Aroa Villoslada, Guallar, Carmen Aured, Abad, Nuria Fernández, Mangas, Pilar García, Adell, Marta Matamala, Palacián Ruiz, Ma Pilar, Porres, Juan Carlos, Ramos-Martínez, Antonio, Muñoz Serrano, Alejandro, de Alarcón González, Arístides, Fernández-Cruz, Ana, Miró, José M<ce:sup loc='post">a</ce:sup>, Ruiz-Morales, Josefa, Sousa-Regueiro, Dolores, Montejo, José Miguel, Gálvez-Acebal, Juan, and HidalgoTenorio, Carmen

Published
2018
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28. Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse

Author

Fernández Sánchez, Fernando, Noureddine, Mariam, Rosas, Gabriel, de la Torre Lima, Javier, Aramendi, José, Bereciartua, Elena, Blanco, María José, Blanco, Roberto, Boado, María Victoria, Campaña Lázaro, Marta, Crespo, Alejandro, Goikoetxea, Josune, Iruretagoyena, José Ramón, Irurzun Zuazabal, Josu, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García López, María Victoria, Ivanova Georgieva, Radka, Ojeda, Guillermo, Rodríguez Bailón, Isabel, Ruiz Morales, Josefa, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Goenaga, Miguel Ángel, Idígoras, Pedro, Iribarren, José Antonio, Izaguirre Yarza, Alberto, Kortajarena Urkola, Xabier, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Miguez Rey, Enrique, Rodríguez Mayo, María, Sánchez, Efrén, Sousa Regueiro, Dolores, Martínez, Francisco Javier, Alonso, María del Mar, Castro, Beatriz, García Rosado, Dácil, Durán, Mª del Carmen, Miguel Gómez, Mª Antonia, Lacalzada, Juan, Nassar, Ibrahim, Plata Ciezar, Antonio, Reguera Iglesias, José Mª, Asensi Álvarez, Víctor, Costas, Carlos, de la Hera, Jesús, Fernández Suárez, Jonnathan, Iglesias Fraile, Lisardo, León Arguero, Víctor, López Menéndez, José, Mencia Bajo, Pilar, Morales, Carlos, Moreno Torrico, Alfonso, Palomo, Carmen, Paya Martínez, Begoña, Rodríguez Esteban, Ángeles, Rodríguez García, Raquel, Telenti Asensio, Mauricio, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Llopis Pérez, Jaume, Marco, Francesc, Miró, José María, Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan Manuel, Pomar, José Luis, Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Celemín, Daniel, Cuerpo Caballero, Gregorio, Delgado Montero, Antonia, Fernández Cruz, Ana, García Mansilla, Ana, García Leoni, María Eugenia, González Ramallo, Víctor, Kestler Hernández, Martha, Hualde, Amaia Mari, Marín, Mercedes, Martínez-Sellés, Manuel, Menárguez, María Cruz, Muñoz, Patricia, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Verde Moreno, Eduardo, Antorrena, Isabel, Loeches, Belén, Martín Quirós, Alejandro, Moreno, Mar, Ramírez, Ulises, Rial Bastón, Verónica, Romero, María, Saldaña, Araceli, Agüero Balbín, Jesús, Armiñanzas Castillo, Carlos, Arnaiz, Ana, Arnaiz de las Revillas, Francisco, Cobo Belaustegui, Manuel, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Gómez Izquierdo, Rubén, García, Iván, González Rico, Claudia, Gutiérrez-Cuadra, Manuel, Gutiérrez Díez, José, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Domínguez, Fernando, García-Pavía, Pablo, Mirelis, Jesús González, Orden, Beatriz, Ramos, Antonio, Cobo-Marcos, Marta, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Ruiz, Soledad, Hidalgo Tenorio, Carmen, Almendro Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo Jambrina, Román, de Cueto, Marina, Gálvez Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Fernández, Ángel Luis, Martínez, Amparo, Prieto, Arturo, Regueiro, Benito, Vega, Marino, Blasco, Andrés Canut, Mollar, José Cordo, Gainzarain Arana, Juan Carlos, García Uriarte, Oscar, Martín López, Alejandro, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, García Domínguez, Gloria, Sánchez-Porto, Antonio, Arribas Leal, José Mª, García Vázquez, Elisa, Hernández Torres, Alicia, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Moreno Rodríguez, Anai, Tarabini-Castellani, Paola, Heredero Gálvez, Eva, Maicas Bellido, Carolina, Largo Pau, José, Sepúlveda, María Antonia, Toledano Sierra, Pilar, Iqbal-Mirza, Sadaf Zafar, Cascales Alcolea, Eva, Egea Serrano, Pilar, Hernández Roca, José Joaquín, Keituqwa Yañez, Ivan, Peláez Ballesta, Ana, Soriano, Víctor, Moreno Escobar, Eduardo, Peña Monje, Alejandro, Sánchez Cabrera, Valme, Vinuesa García, David, Arrizabalaga Asenjo, María, Cifuentes Luna, Carmen, Núñez Morcillo, Juana, Pérez Seco, Mª Cruz, Villoslada Gelabert, Aroa, Aured Guallar, Carmen, Fernández Abad, Nuria, García Mangas, Pilar, Matamala Adell, Marta, Palacián Ruiz, Mª Pilar, Porres, Juan Carlos, Alcaraz Vidal, Begoña, Cobos Trigueros, Nazaret, Del Amor Espín, María Jesús, Giner Caro, José Antonio, Jiménez Sánchez, Roberto, Jimeno Almazán, Amaya, Ortín Freire, Alejandro, Viqueira González, Monserrat, Pericás Ramis, Pere, Ribas Blanco, Mª Ángels, Ruiz de Gopegui Bordes, Enrique, Vidal Bonet, Laura, Bellón Munera, Mª Carmen, Escribano Garaizabal, Elena, Tercero Martínez, Antonia, Segura Luque, Juan Carlos, Zegri-Reiriz, Isabel, Martínez Sellés, Manuel, González-Ramallo, Victor, Miro, Jose M., Falces, Carles, Gonzalez Rico, Claudia, Rodriguez Alvarez, Regino, Reguera Iglesias, Jose Maria, Dominguez, Fernando, and Garcia-Pavia, Pablo

Published
2018
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29. Digital health.

Author

van der Schors, Tjalling, Blázquez, Ana Lozano, Poje, Darija Kuruc, Miljković, Nenad, Süle, András, and Kohl, Stephanie

Published
2024
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31. Lipid signatures of West Nile virus infection unveil alterations of sphingolipid metabolism providing novel biomarkers

Author

Mingo-Casas, Patricia, primary, Sanchez-Céspedes, Javier, additional, Blázquez, Ana-Belén, additional, Casas, Josefina, additional, Balsera-Manzanero, María, additional, Herrero, Laura, additional, Vázquez, Ana, additional, Pachón, Jerónimo, additional, Aguilar-Guisado, Manuela, additional, Cisneros, José Miguel, additional, Saiz, Juan-Carlos, additional, and Martín-Acebes, Miguel A., additional

Published
2023
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37. Pharmacological Elevation of Cellular Dihydrosphingomyelin Provides a Novel Antiviral Strategy against West Nile Virus Infection

Author

Jiménez de Oya, Nereida, primary, San-Félix, Ana, additional, Casasampere, Mireia, additional, Blázquez, Ana-Belén, additional, Mingo-Casas, Patricia, additional, Escribano-Romero, Estela, additional, Calvo-Pinilla, Eva, additional, Poderoso, Teresa, additional, Casas, Josefina, additional, Saiz, Juan-Carlos, additional, Pérez-Pérez, María-Jesús, additional, and Martín-Acebes, Miguel A., additional

Published
2023
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38. Identification of West Nile virus RNA-dependent RNA polymerase non-nucleoside inhibitors by real-time high throughput fluorescence screening

Author

García-Zarandieta, Marta, primary, Quesada, Ernesto, additional, Martínez-Jiménez, María I., additional, Newnes, Cristina V., additional, Fernández-Cabello, Victor, additional, Sáez-Álvarez, Yanira, additional, Blázquez, Ana-Belén, additional, Escribano-Romero, Estela, additional, Saiz, Juan-Carlos, additional, Del Aguila, Carmen, additional, Martín-Acebes, Miguel A., additional, Pérez-Pérez, María-Jesús, additional, and Agudo, Rubén, additional

Published
2023
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40. Glycolytic shift during West Nile virus infection provides new therapeutic opportunities

Author

Ministerio de Ciencia e Innovación (España), European Commission, San-Félix, Ana [0000-0003-4271-7598], Peréz-Pérez, María-Jesús [0000-0003-1336-7760], Mingo-Casas, Patricia, Blázquez, Ana‑Belén, Gómez de Cedrón, Marta, San-Félix, Ana, Molina, Susana, Escribano‑Romero, Estela, Calvo‑Pinilla, Eva, Jiménez de Oya, Nereida, Ramírez de Molina, Ana, Saiz, Juan‑Carlos, Peréz-Pérez, María-Jesús, Martín Acebes, Miguel A., Ministerio de Ciencia e Innovación (España), European Commission, San-Félix, Ana [0000-0003-4271-7598], Peréz-Pérez, María-Jesús [0000-0003-1336-7760], Mingo-Casas, Patricia, Blázquez, Ana‑Belén, Gómez de Cedrón, Marta, San-Félix, Ana, Molina, Susana, Escribano‑Romero, Estela, Calvo‑Pinilla, Eva, Jiménez de Oya, Nereida, Ramírez de Molina, Ana, Saiz, Juan‑Carlos, Peréz-Pérez, María-Jesús, and Martín Acebes, Miguel A.

Abstract

Background Viral rewiring of host bioenergetics and immunometabolism may provide novel targets for therapeu‑ tic interventions against viral infections. Here, we have explored the effect on bioenergetics during the infection with the mosquito‑borne flavivirus West Nile virus (WNV), a medically relevant neurotropic pathogen causing out‑ breaks of meningitis and encephalitis worldwide. Results A systematic literature search and meta‑analysis pointed to a misbalance of glucose homeostasis in the cen‑ tral nervous system of WNV patients. Real‑time bioenergetic analyses confirmed upregulation of aerobic glycolysis and a reduction of mitochondrial oxidative phosphorylation during viral replication in cultured cells. Transcriptom‑ ics analyses in neural tissues from experimentally infected mice unveiled a glycolytic shift including the upregula‑ tion of hexokinases 2 and 3 (Hk2 and Hk3) and pyruvate dehydrogenase kinase 4 (Pdk4). Treatment of infected mice with the Hk inhibitor, 2‑deoxy‑D‑glucose, or the Pdk4 inhibitor, dichloroacetate, alleviated WNV‑induced neuroinflammation. Conclusions These results highlight the importance of host energetic metabolism and specifically glycolysis in WNV infection in vivo. This study provides proof of concept for the druggability of the glycolytic pathway for the future development of therapies to combat WNV pathology.

Published
2023

41. Lipid signatures of West Nile virus infection unveil alterations of sphingolipid metabolism providing novel biomarkers

Author

Ministerio de Ciencia e Innovación (España), 0000-0003-1207-240X, 0000-0003-2707-1979, 0000-0002-0847-0977, 0000-0002-7926-5209, 0000-0001-5667-925X, 0000-0002-9872-3316, 0000-0002-8166-5308, 0000-0001-5639-9434, 0000-0001-5001-672X, 0000-0001-8269-5544, 0000-0001-6015-3613, Mingo-Casas, Patricia, Sánchez-Céspedes, Javier, Blázquez, Ana-Belén, Casas, Josefina, Balsera-Manzanero, María, Herrero, Laura, Vázquez, Ana, Pachón, Jerónimo, Aguilar-Guisado, Manuela, Cisneros, José Miguel, Saiz Calahorra, Juan Carlos, Martín-Acebes, M. A., Ministerio de Ciencia e Innovación (España), 0000-0003-1207-240X, 0000-0003-2707-1979, 0000-0002-0847-0977, 0000-0002-7926-5209, 0000-0001-5667-925X, 0000-0002-9872-3316, 0000-0002-8166-5308, 0000-0001-5639-9434, 0000-0001-5001-672X, 0000-0001-8269-5544, 0000-0001-6015-3613, Mingo-Casas, Patricia, Sánchez-Céspedes, Javier, Blázquez, Ana-Belén, Casas, Josefina, Balsera-Manzanero, María, Herrero, Laura, Vázquez, Ana, Pachón, Jerónimo, Aguilar-Guisado, Manuela, Cisneros, José Miguel, Saiz Calahorra, Juan Carlos, and Martín-Acebes, M. A.

Abstract

West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bites of infected mosquitoes. Severe forms of West Nile disease (WND) can curse with meningitis, encephalitis or acute flaccid paralysis. A better understanding of the physiopathology associated with disease progression is mandatory to find biomarkers and effective therapies. In this scenario, blood derivatives (plasma and serum) constitute the more commonly used biofluids due to its ease of collection and high value for diagnostic purposes. Therefore, the potential impact of this virus in the circulating lipidome was addressed combining the analysis of samples from experimentally infected mice and naturally WND patients. Our results unveil dynamic alterations in the lipidome that define specific metabolic fingerprints of different infection stages. Concomitant with neuroinvasion in mice, the lipid landscape was dominated by a metabolic reprograming that resulted in significant elevations of circulating sphingolipids (ceramides, dihydroceramides, and dihydrosphingomyelins), phosphatidylethanolamines and triacylglycerols. Remarkably, patients suffering from WND also displayed an elevation of ceramides, dihydroceramides, lactosylceramides, and monoacylglycerols in their sera. The dysregulation of sphingolipid metabolism by WNV may provide new therapeutic opportunities and supports the potential of certain lipids as novel peripheral biomarkers of WND progression.

Published
2023

42. Long-term bathymetric changes in the submerged delta of the Turia river since the nineteenth century (Western Mediterranean) and their drivers

Author

Universidad Católica de Valencia San Vicente Mártir, Garcés, Rafael, Roca Mora, Mar, Martínez-Clavel, Borja, Blázquez, Ana M., Universidad Católica de Valencia San Vicente Mártir, Garcés, Rafael, Roca Mora, Mar, Martínez-Clavel, Borja, and Blázquez, Ana M.

Abstract

Deltas and estuaries are formed through periods of marine transgression and regression, which are the continuity of a river and provide key information about its evolution. However, many of the world's deltas are increasingly exposed to the impacts of human activities. While changes affecting the subaerial parts of deltas have been intensively studied, much less is known of their subaqueous parts, the understanding of which is important in gauging overall potential delta vulnerability. This research evaluates the bathymetric changes in the submerged delta of the Turia river (Western Mediterranean, Spain) before and after the extreme flood event of 1957, after which the riverbed was diverted. Three nautical charts were processed (1878, 1988 and 2022), including georeferencing and Digital Elevation Model (DEM) generation. In order to evaluate changes before and after the event, models for 1878–1988 and 1988–2022 were compared and differences were quantified in order to assess erosion and aggradation trends. The results indicate a more aggradated submerged delta in the surroundings of the old river mouth, favored by the high sediment availability since the end of the Little Ice Age (LIA), and the presence of a smaller delta next to its current river mouth to the south of the harbor of Valencia. Bathymetric reconstructions also made it possible to map some incisions in the inner continental shelf as river channels that migrated eastwards when the sea level was lower during MIS 2. Finally, the comparison of bathymetric models also revealed the scarcity of sediments on the current shelf since 1988, which is attributed to anthropogenic action. The successive extensions of the harbor are increasingly distorting the distribution of sediments along the coast and are thus remodeling seabed sediment distribution. Knowing the sedimentation in deltaic systems means better predicting future alterations due to increased anthropization and of the climate change.

Published
2023

46. Pharmacological elevation of cellular dihydrosphingomyelin provides a novel antiviral strategy against West Nile virus infection

Author

Jiménez de Oya, Nereida, primary, San-Félix, Ana, additional, Casasampere, Mireia, additional, Blázquez, Ana-Belén, additional, Mingo-Casas, Patricia, additional, Escribano-Romero, Estela, additional, Calvo-Pinilla, Eva, additional, Poderoso, Teresa, additional, Casas, Josefina, additional, Saiz, Juan-Carlos, additional, Pérez-Pérez, María-Jesús, additional, and Martín-Acebes, Miguel A., additional

Published
2022
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47. Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation

Author

Álvarez-Fernández, Hadrián, primary, Mingo-Casas, Patricia, additional, Blázquez, Ana-Belén, additional, Caridi, Flavia, additional, Saiz, Juan Carlos, additional, Pérez-Pérez, María-Jesús, additional, Martín-Acebes, Miguel A., additional, and Priego, Eva-María, additional

Published
2022
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48. Ofimática. 2ª Edición.

Author

Rosado Alcántara, Fco. Manuel, Jorge Blázquez, Ana Belén, Rosado Alcántara, Fco. Manuel, and Jorge Blázquez, Ana Belén

Published
2016

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