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6. Decline in Isotope Dilution Space Ratio Above Age 60 Could Affect Energy Estimates Using the Doubly Labeled Water Method

Author

Wong, William W, Speakman, John R, Ainslie, Philip N, Anderson, Liam J, Arab, Leonore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan G, Casper, Regina, Close, Graeme L, Colbert, Lisa H, Cooper, Jamie A, Das, Sai K, Davies, Peter SW, Eaton, Simon, Ekelund, Ulf, Hambly, Catherine, El Hamdouchi, Asmaa, Entringer, Sonja, Fudge, Barry W, Gillingham, Melanie, Goris, Annelies H, Gurven, Micheal, Hoos, Marije B, Hu, Sumei, Joosen, Annemiek, Katzmarzyk, Peter T, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Larsson, Christel L, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietilainen, Kirsi H, Pitsiladis, Yannis P, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto, Racette, Susan B, Raichen, David A, Redman, Leanne, Ravussin, Eric, Reilly, John J, Roberts, Susan, Scuitt, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, van Etten, Ludo M, Van Mil, Edgar A, Verbunt, Jeanine A, Wells, Jonathan CK, Wilson, George, Yoshida, Tsukasa, Zhang, Xueying, Loechl, Cornelia U, Luke, Amy, Murphy-Alford, Alexia J, Pontzer, Herman, Sagayama, Hiroyuki, Rood, Jennifer C, Schoeller, Dale A, Westerterp, Klaas R, and Yamada, Yosuke

Published
2024
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7. Variation in human water turnover associated with environmental and lifestyle factors

Author

Yamada, Yosuke, Zhang, Xueying, Henderson, Mary ET, Sagayama, Hiroyuki, Pontzer, Herman, Watanabe, Daiki, Yoshida, Tsukasa, Kimura, Misaka, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan G, Close, Graeme L, Cooper, Jamie A, Cooper, Richard, Das, Sai Krupa, Dugas, Lara R, Eaton, Simon, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Halsey, Lewis G, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kraus, William E, Kriengsinyos, Wantanee, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Redman, Leanne M, Reilly, John J, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sardinha, Luis B, Silva, Analiza M, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack A, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Westerterp, Klaas R, Wong, William W, Miyachi, Motohiko, Schoeller, Dale A, Speakman, John R, and Consortium§, International Atomic Energy Agency Doubly Labeled Water Database

Subjects
Prevention, Clean Water and Sanitation, Female, Humans, Pregnancy, Exercise, Humidity, Life Style, Social Class, Water, Infant, Newborn, Infant, Child, Preschool, Child, Adolescent, Young Adult, Adult, Middle Aged, Aged, Aged, 80 and over, Drinking, International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium§, General Science & Technology
Abstract

Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking (2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.

Published
2022

8. Variability in energy expenditure is much greater in males than females

Author

Halsey, Lewis G, Careau, Vincent, Pontzer, Herman, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Cooper, Richard, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Sagayama, Hiroyuki, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Yamada, Yosuke, and Speakman, John R

Subjects
Obesity, Behavioral and Social Science, Affordable and Clean Energy, Adult, Aged, Aging, Animals, Body Composition, Energy Metabolism, Female, Humans, Male, Mammals, Reproduction, Sex Characteristics, DLW, Energetics, Activity, Trait variability, Biological sex, Evolutionary Biology, Anthropology, Archaeology
Abstract

In mammals, trait variation is often reported to be greater among males than females. However, to date, mainly only morphological traits have been studied. Energy expenditure represents the metabolic costs of multiple physical, physiological, and behavioral traits. Energy expenditure could exhibit particularly high greater male variation through a cumulative effect if those traits mostly exhibit greater male variation, or a lack of greater male variation if many of them do not. Sex differences in energy expenditure variation have been little explored. We analyzed a large database on energy expenditure in adult humans (1494 males and 3108 females) to investigate whether humans have evolved sex differences in the degree of interindividual variation in energy expenditure. We found that, even when statistically comparing males and females of the same age, height, and body composition, there is much more variation in total, activity, and basal energy expenditure among males. However, with aging, variation in total energy expenditure decreases, and because this happens more rapidly in males, the magnitude of greater male variation, though still large, is attenuated in older age groups. Considerably greater male variation in both total and activity energy expenditure could be explained by greater male variation in levels of daily activity. The considerably greater male variation in basal energy expenditure is remarkable and may be explained, at least in part, by greater male variation in the size of energy-demanding organs. If energy expenditure is a trait that is of indirect interest to females when choosing a sexual partner, this would suggest that energy expenditure is under sexual selection. However, we present a novel energetics model demonstrating that it is also possible that females have been under stabilizing selection pressure for an intermediate basal energy expenditure to maximize energy available for reproduction.

Published
2022

10. Human total, basal and activity energy expenditures are independent of ambient environmental temperature

Author

Zhang, Xueying, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Blaak, Ellen E, Buchowski, Maciej S, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Dugas, Lara R, Gurven, Michael, Hamdouchi, Asmaa El, Hu, Sumei, Joonas, Noorjehan, Katzmarzyk, Peter, Kraus, William E, Kushner, Robert F, Leonard, William R, Martin, Corby K, Meijer, Erwin P, Neuhouser, Marian L, Ojiambo, Robert M, Pitsiladis, Yannis P, Plasqui, Guy, Prentice, Ross L, Racette, Susan B, Ravussin, Eric, Redman, Leanne M, Reynolds, Rebecca M, Roberts, Susan B, Sardinha, Luis B, Silva, Analiza M, Stice, Eric, Urlacher, Samuel S, Van Mil, Edgar A, Wood, Brian M, Murphy-Alford, Alexia J, Loechl, Cornelia, Luke, Amy H, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Pontzer, Herman, Speakman, John R, consortium, the IAEA DLW database, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Addo, Bedu, Blanc, Stephane, Bonomi, Alberto, Bouten, Carlijn VC, Bovet, Pascal, Branth, Stefan, De Bruin, Niels C, Butte, Nancy F, Colbert, Lisa H, Camps, Stephan G, Dutman, Alice E, Eaton, Simon D, Ekelund, Ulf, Entringer, Sonja, Ebbeling, Cara, Elmståhl, Sölve, Fogelholm, Mikael, Forrester, Terrence, Fudge, Barry W, Harris, Tamara, Heijligenberg, Rik, Goris, Annelies H, Hambly, Catherine, Hoos, Marije B, Jorgensen, Hans U, Joosen, Annemiek M, Kempen, Kitty P, Kimura, Misaka, Kriengsinyos, Watanee, Lambert, Estelle V, Larsson, Christel L, Lessan, Nader, Ludwig, David S, McCloskey, Margaret, Medin, Anine C, Meijer, Gerwin A, Matsiko, Eric, Melse-Boonstra, Alida, Morehen, James C, Morton, James P, Nicklas, Theresa A, Pannemans, Daphne L, Pietiläinen, Kirsi H, Philippaerts, Renaat M, Rabinovich, Roberto A, Reilly, John J, Rothenberg, Elisabet M, Schuit, Albertine J, Schulz, Sabine, and Sjödin, Anders M

Subjects
Nutrition, IAEA DLW database consortium, Human Physiology, Human activity in medical context, Human metabolism
Abstract

Lower ambient temperature (Ta) requires greater energy expenditure to sustain body temperature. However, effects of Ta on human energetics may be buffered by environmental modification and behavioral compensation. We used the IAEA DLW database for adults in the USA (n = 3213) to determine the effect of Ta (-10 to +30°C) on TEE, basal (BEE) and activity energy expenditure (AEE) and physical activity level (PAL). There were no significant relationships (p > 0.05) between maximum, minimum and average Ta and TEE, BEE, AEE and PAL. After adjustment for fat-free mass, fat mass and age, statistically significant (p

Published
2022

13. Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition

Author

Rimbach, Rebecca, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Anderson, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, El Hamdouchi, Asmaa, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Speakman, John R, and Pontzer, Herman

Subjects
Nutrition, Pediatric, Clinical Research, Obesity, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Adipose Tissue, Adult, Bayes Theorem, Body Composition, Child, Databases, Factual, Energy Metabolism, Female, Humans, Isotope Labeling, Longitudinal Studies, Male, Middle Aged, Water, Weight Gain, IAEA DLW Database Consortium
Abstract

Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.

Published
2022

14. Physical activity and fat-free mass during growth and in later life

Author

Westerterp, Klaas R, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai K, Cooper, Richard, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Pontzer, Herman, Rood, Jennifer, Schoeller, Dale A, Wong, William W, Speakman, John R, Branth, Stefan, Colbert, Lisa H, De Bruin, Niels C, Dutman, Alice E, Elmståhl, Sölve, Fogelholm, Mikael, Harris, Tamara, Heijligenberg, Rik, Jorgensen, Hans U, Larsson, Christel L, Rothenberg, Elisabet M, McCloskey, Margaret, Meijer, Gerwin A, Pannemans, Daphne L, Schulz, Sabine, Van den Berg-Emons, Rita, Van Gemert, Wim G, and Wilhelmine, W

Subjects
Prevention, Aging, Clinical Research, Nutrition, Adipose Tissue, Adolescent, Adult, Aged, Aged, 80 and over, Body Composition, Child, Child, Preschool, Cross-Sectional Studies, Energy Metabolism, Exercise, Female, Humans, Male, Middle Aged, Young Adult, physical activity level, age, energy expenditure, body composition, doubly labeled water, International Atomic Energy Agency Doubly Labeled Water database group, Engineering, Medical and Health Sciences, Nutrition & Dietetics
Abstract

BackgroundPhysical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass.ObjectivesA study is presented of the association between FFM and physical activity in relation to age.MethodsIn a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3-96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution.ResultsPAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males

Published
2021

15. Energy compensation and adiposity in humans

Author

Careau, Vincent, Halsey, Lewis G, Pontzer, Herman, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Cooper, Richard, Dugas, Lara R, Eaton, Simon D, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reilly, John J, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Sagayama, Hiroyuki, Schoeller, Dale A, Wong, William W, Yamada, Yosuke, Speakman, John R, and group, the IAEA DLW database

Subjects
Nutrition, Obesity, Clinical Research, Oral and gastrointestinal, Stroke, Metabolic and endocrine, Cancer, Cardiovascular, Affordable and Clean Energy, Adiposity, Energy Intake, Energy Metabolism, Humans, IAEA DLW database group, Homo sapiens, activity, basal metabolic rate, daily energy expenditure, energy compensation, energy management models, exercise, trade-offs, weight loss, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental Biology
Abstract

Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures.1-3 This suggestion has profound implications for both the evolution of metabolism and human health. It implies that a long-term increase in activity does not directly translate into an increase in total energy expenditure (TEE) because other components of TEE may decrease in response-energy compensation. We used the largest dataset compiled on adult TEE and basal energy expenditure (BEE) (n = 1,754) of people living normal lives to find that energy compensation by a typical human averages 28% due to reduced BEE; this suggests that only 72% of the extra calories we burn from additional activity translates into extra calories burned that day. Moreover, the degree of energy compensation varied considerably between people of different body compositions. This association between compensation and adiposity could be due to among-individual differences in compensation: people who compensate more may be more likely to accumulate body fat. Alternatively, the process might occur within individuals: as we get fatter, our body might compensate more strongly for the calories burned during activity, making losing fat progressively more difficult. Determining the causality of the relationship between energy compensation and adiposity will be key to improving public health strategies regarding obesity.

Published
2021

17. An integrated single cell and spatial transcriptomic map of human white adipose tissue

Author

Massier, Lucas, Jalkanen, Jutta, Elmastas, Merve, Zhong, Jiawei, Wang, Tongtong, Nono Nankam, Pamela A., Frendo-Cumbo, Scott, Bäckdahl, Jesper, Subramanian, Narmadha, Sekine, Takuya, Kerr, Alastair G., Tseng, Ben T. P., Laurencikiene, Jurga, Buggert, Marcus, Lourda, Magda, Kublickiene, Karolina, Bhalla, Nayanika, Andersson, Alma, Valsesia, Armand, Astrup, Arne, Blaak, Ellen E., Ståhl, Patrik L., Viguerie, Nathalie, Langin, Dominique, Wolfrum, Christian, Blüher, Matthias, Rydén, Mikael, and Mejhert, Niklas

Published
2023
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18. Daily energy expenditure through the human life course

Author

Pontzer, Herman, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan G, Close, Graeme L, Cooper, Jamie A, Cooper, Richard, Das, Sai Krupa, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marjije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Teresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia, Luke, Amy H, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Speakman, John R, and Consortium§, IAEA DLW Database

Subjects
Aging, Nutrition, Adolescent, Adult, Aged, Aged, 80 and over, Basal Metabolism, Body Composition, Body Weight, Child, Child, Preschool, Energy Metabolism, Exercise, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Pregnancy, Young Adult, IAEA DLW Database Consortium, General Science & Technology
Abstract

Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Published
2021

19. A standard calculation methodology for human doubly labeled water studies.

Author

Speakman, John R, Yamada, Yosuke, Sagayama, Hiroyuki, Berman, Elena SF, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Creasy, Seth A, Das, Sai Krupa, Cooper, Richard, Dugas, Lara R, Ebbeling, Cara B, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, El Hamdouchi, Asmaa, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Ludwig, David S, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Melanson, Edward L, Luke, Amy H, Pontzer, Herman, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, and IAEA DLW database group

Subjects
IAEA DLW database group, doubly labeled water, free-living, total energy expenditure, validation
Abstract

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (

Published
2021

20. Goals in Nutrition Science 2020-2025

Author

Bassaganya-Riera, Josep, Berry, Elliot M, Blaak, Ellen E, Burlingame, Barbara, le Coutre, Johannes, van Eden, Willem, El-Sohemy, Ahmed, German, J Bruce, Knorr, Dietrich, Lacroix, Christophe, Muscaritoli, Maurizio, Nieman, David C, Rychlik, Michael, Scholey, Andrew, and Serafini, Mauro

Subjects
Prevention, Nutrition, Zero Hunger, Good Health and Well Being, technology, health, food system, sustainability, nutrition sciences, Agricultural Biotechnology, Nutrition and Dietetics
Abstract

Five years ago, with the editorial board of Frontiers in Nutrition, we took a leap of faith to outline the Goals for Nutrition Science - the way we see it (1). Now, in 2020, we can put ourselves to the test and take a look back. Without a doubt we got it right with several of the key directions. To name a few, Sustainable Development Goals (SDGs) for Food and Nutrition are part of the global public agenda, and the SDGs contribute to the structuring of international science and research. Nutritional Science has become a critical element in strengthening work on the SDGs, and the development of appropriate methodologies is built on the groundwork of acquiring and analyzing big datasets. Investigation of the Human Microbiome is providing novel insight on the interrelationship between nutrition, the immune system and disease. Finally, with an advanced definition of the gut-brain-axis we are getting a glimpse into the potential for Nutrition and Brain Health. Various milestones have been achieved, and any look into the future will have to consider the lessons learned from Covid-19 and the sobering awareness about the frailty of our food systems in ensuring global food security. With a view into the coming 5 years from 2020 to 2025, the editorial board has taken a slightly different approach as compared to the previous Goals article. A mind map has been created to outline the key topics in nutrition science. Not surprisingly, when looking ahead, the majority of scientific investigation required will be in the areas of health and sustainability. Johannes le Coutre, Field Chief Editor, Frontiers in Nutrition.

Published
2021

21. Goals in Nutrition Science 2020-2025.

Author

Bassaganya-Riera, Josep, Berry, Elliot M, Blaak, Ellen E, Burlingame, Barbara, le Coutre, Johannes, van Eden, Willem, El-Sohemy, Ahmed, German, J Bruce, Knorr, Dietrich, Lacroix, Christophe, Muscaritoli, Maurizio, Nieman, David C, Rychlik, Michael, Scholey, Andrew, and Serafini, Mauro

Subjects
food system, health, nutrition sciences, sustainability, technology, Agricultural Biotechnology, Nutrition and Dietetics
Abstract

Five years ago, with the editorial board of Frontiers in Nutrition, we took a leap of faith to outline the Goals for Nutrition Science - the way we see it (1). Now, in 2020, we can put ourselves to the test and take a look back. Without a doubt we got it right with several of the key directions. To name a few, Sustainable Development Goals (SDGs) for Food and Nutrition are part of the global public agenda, and the SDGs contribute to the structuring of international science and research. Nutritional Science has become a critical element in strengthening work on the SDGs, and the development of appropriate methodologies is built on the groundwork of acquiring and analyzing big datasets. Investigation of the Human Microbiome is providing novel insight on the interrelationship between nutrition, the immune system and disease. Finally, with an advanced definition of the gut-brain-axis we are getting a glimpse into the potential for Nutrition and Brain Health. Various milestones have been achieved, and any look into the future will have to consider the lessons learned from Covid-19 and the sobering awareness about the frailty of our food systems in ensuring global food security. With a view into the coming 5 years from 2020 to 2025, the editorial board has taken a slightly different approach as compared to the previous Goals article. A mind map has been created to outline the key topics in nutrition science. Not surprisingly, when looking ahead, the majority of scientific investigation required will be in the areas of health and sustainability. Johannes le Coutre, Field Chief Editor, Frontiers in Nutrition.

Published
2020

23. Variability in energy expenditure is much greater in males than females

Author

Halsey, Lewis G., Careau, Vincent, Pontzer, Herman, Ainslie, Philip N., Andersen, Lene F., Anderson, Liam J., Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.C., Bovet, Pascal, Buchowski, Maciej S., Butte, Nancy F., Camps, Stefan G.J.A., Close, Graeme L., Cooper, Jamie A., Das, Sai Krupa, Cooper, Richard, Dugas, Lara R., Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W., Goris, Annelies H., Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M., Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kushner, Robert F., Lambert, Estelle V., Leonard, William R., Lessan, Nader, Martin, Corby K., Medin, Anine C., Meijer, Erwin P., Morehen, James C., Morton, James P., Neuhouser, Marian L., Nicklas, Theresa A., Ojiambo, Robert M., Pietiläinen, Kirsi H., Pitsiladis, Yannis P., Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto A., Racette, Susan B., Raichlen, David A., Ravussin, Eric, Reynolds, Rebecca M., Roberts, Susan B., Schuit, Albertine J., Sjödin, Anders M., Stice, Eric, Urlacher, Samuel S., Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Wilson, George, Wood, Brian M., Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J., Loechl, Cornelia U., Luke, Amy H., Rood, Jennifer, Sagayama, Hiroyuki, Schoeller, Dale A., Westerterp, Klaas R., Wong, William W., Yamada, Yosuke, and Speakman, John R.

Published
2022
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24. Health Effects of Increasing Protein Intake Above the Current Population Reference Intake in Older Adults: A Systematic Review of the Health Council of the Netherlands

Author

Hengeveld, Linda M, de Goede, Janette, Afman, Lydia A, Bakker, Stephan J L, Beulens, Joline W J, Blaak, Ellen E, Boersma, Eric, Geleijnse, Johanna M, van Goudoever, Johannes (Hans) B, Hopman, Maria T E, Iestra, Jolein A, Kremers, Stef P J, Mensink, Ronald P, de Roos, Nicole M, Stehouwer, Coen D A, Verkaik-Kloosterman, Janneke, de Vet, Emely, and Visser, Marjolein

Published
2022
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25. Impaired Mitochondrial Respiration in Upper Compared to Lower Body Differentiated Human Adipocytes and Adipose Tissue.

Author

Lempesis, Ioannis G, Hoebers, Nicole, Essers, Yvonne, Jocken, Johan W E, Dubois, Ludwig J, Blaak, Ellen E, Manolopoulos, Konstantinos N, and Goossens, Gijs H

Subjects
ADIPOSE tissues, MULTIPOTENT stem cells, BRITISH kings & rulers, HUMAN body, FAT, RESPIRATION, OXYGEN consumption
Abstract

Context Abdominal obesity is associated with increased cardiometabolic disease risk, while lower body fat seems to confer protection against obesity-related complications. The functional differences between upper and lower body adipose tissue (AT) remain poorly understood. Objective We aimed to examine whether mitochondrial respiration is impaired in abdominal as compared to femoral differentiated human multipotent adipose-derived stem cells (hMADS; primary outcome) and AT in postmenopausal women. Design In this cross-sectional study, 23 postmenopausal women with normal weight or obesity were recruited at the University of Birmingham/Queen Elizabeth Hospital Birmingham (Birmingham, UK). We collected abdominal and femoral subcutaneous AT biopsies to determine mitochondrial oxygen consumption rates in differentiated abdominal and femoral hMADS. Furthermore, we assessed oxidative phosphorylation (OXPHOS) protein expression and mitochondrial DNA (mtDNA) content in abdominal and femoral AT as well as hMADS. Finally, we explored in vivo fractional oxygen extraction and carbon dioxide release across abdominal and femoral subcutaneous AT in a subgroup of the same individuals with normal weight or obesity. Results We found lower basal and maximal uncoupled mitochondrial oxygen consumption rates in abdominal compared to femoral hMADS. In line, in vivo fractional oxygen extraction and carbon dioxide release were lower across abdominal than femoral AT. OXPHOS protein expression and mtDNA content did not significantly differ between abdominal and femoral differentiated hMADS and AT. Conclusion The present findings demonstrate that in vitro mitochondrial respiration and in vivo oxygen fractional extraction are less in upper compared to lower body differentiated hMADS and AT, respectively, in postmenopausal women. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Immunometabolic Signatures of Circulating Monocytes in Humans with Obesity and Insulin Resistance

Author

Smeehuijzen, Lisa, primary, Gijbels, Anouk, additional, Nugteren-Boogaard, Joline P., additional, Vrieling, Frank, additional, Boudjadja, Mehdi Boutagouga, additional, Trouwborst, Inez, additional, Jardon, Kelly M., additional, Hul, Gabby B., additional, Feskens, Edith J.M., additional, Blaak, Ellen E., additional, Goossens, Gijs H., additional, Afman, Lydia A., additional, and Stienstra, Rinke, additional

Published
2024
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33. Intestinal gases as a non-invasive measurement of microbial fermentation and host health.

Author

Larik, Gillian N.F., Canfora, Emanuel E., van Schothorst, Evert M., and Blaak, Ellen E.

Abstract

Microbial fermentation and associated products provide insights into the gut microbiota-host relationship. Here, we propose using improved technologies that allow non-invasive, real-time measurements of intestinal gases as a metric for microbial fermentation. This approach has the potential to provide a basis for personalized interventions that improve host metabolic health. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Quantifying postprandial glucose responses using a hybrid modeling approach: Combining mechanistic and data-driven models in The Maastricht Study

Author

Erdős, Balázs, primary, van Sloun, Bart, additional, Goossens, Gijs H., additional, O’Donovan, Shauna D., additional, de Galan, Bastiaan E., additional, van Greevenbroek, Marleen M. J., additional, Stehouwer, Coen D. A., additional, Schram, Miranda T., additional, Blaak, Ellen E., additional, Adriaens, Michiel E., additional, van Riel, Natal A. W., additional, and Arts, Ilja C. W., additional

Published
2023
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47. Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

Author

Kootte, Ruud S., Levin, Evgeni, Salojärvi, Jarkko, Smits, Loek P., Hartstra, Annick V., Udayappan, Shanti D., Hermes, Gerben, Bouter, Kristien E., Koopen, Annefleur M., Holst, Jens J., Knop, Filip K., Blaak, Ellen E., Zhao, Jing, Smidt, Hauke, Harms, Amy C., Hankemeijer, Thomas, Bergman, Jacques J.G.H.M., Romijn, Hans A., Schaap, Frank G., Olde Damink, Steven W.M., Ackermans, Mariette T., Dallinga-Thie, Geesje M., Zoetendal, Erwin, de Vos, Willem M., Serlie, Mireille J., Stroes, Erik S.G., Groen, Albert K., and Nieuwdorp, Max

Published
2017
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50. Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial

Author

Goni, Leticia, Qi, Lu, Cuervo, Marta, Milagro, Fermín I, Saris, Wim H, MacDonald, Ian A, Langin, Dominique, Astrup, Arne, Arner, Peter, Oppert, Jean-Michel, Svendstrup, Mathilde, Blaak, Ellen E, Sørensen, Thorkild IA, Hansen, Torben, and Martínez, J Alfredo

Published
2017
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