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1. T(ether) : Spatially-aware handhelds, gestures and proprioception for multi-user 3D modeling and animation

Author

Lakatos, D., Blackshaw, M., Olwal, Alex, Barryte, Z., Perlin, K., Ishii, H., Lakatos, D., Blackshaw, M., Olwal, Alex, Barryte, Z., Perlin, K., and Ishii, H.

Abstract

T(ether) is a spatially-aware display system for multi-user, collaborative manipulation and animation of virtual 3D objects. The handheld display acts as a window into virtual reality, providing users with a perspective view of 3D data. T(ether) tracks users' heads, hands, fingers and pinching, in addition to a handheld touch screen, to enable rich interaction with the virtual scene. We introduce gestural interaction techniques that exploit proprioception to adapt the UI based on the hand's position above, behind or on the surface of the display. These spatial interactions use a tangible frame of reference to help users manipulate and animate the model in addition to controlling environment properties. We report on initial user observations from an experiment for 3D modeling, which indicate T(ether)'s potential for embodied viewport control and 3D modeling interactions., QC 20141219

Published
2014
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3. Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.

Author

Andreassen CN, Rosenstein BS, Kerns SL, Ostrer H, De Ruysscher D, Cesaretti JA, Barnett GC, Dunning AM, Dorling L, West CML, Burnet NG, Elliott R, Coles C, Hall E, Fachal L, Vega A, Gómez-Caamaño A, Talbot CJ, Symonds RP, De Ruyck K, Thierens H, Ost P, Chang-Claude J, Seibold P, Popanda O, Overgaard M, Dearnaley D, Sydes MR, Azria D, Koch CA, Parliament M, Blackshaw M, Sia M, Fuentes-Raspall MJ, Ramon Y Cajal T, Barnadas A, Vesprini D, Gutiérrez-Enríquez S, Mollà M, Díez O, Yarnold JR, Overgaard J, Bentzen SM, and Alsner J

Subjects
Alleles, Breast Neoplasms genetics, Female, Genetic Predisposition to Disease, Genotype, Heterozygote, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Prostatic Neoplasms genetics, Radiation Injuries etiology, Radiation Tolerance genetics, Radiotherapy adverse effects, Risk Factors, Ataxia Telangiectasia Mutated Proteins genetics, Breast Neoplasms radiotherapy, Prostatic Neoplasms radiotherapy, Radiation Injuries genetics
Abstract

Purpose: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium., Materials and Methods: The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity., Results: For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds ratios of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance., Conclusion: This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

Published
2016
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4. Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer.

Author

Kerns SL, Stock RG, Stone NN, Blacksburg SR, Rath L, Vega A, Fachal L, Gómez-Caamaño A, De Ruysscher D, Lammering G, Parliament M, Blackshaw M, Sia M, Cesaretti J, Terk M, Hixson R, Rosenstein BS, and Ostrer H

Subjects
Aged, Gastrointestinal Hemorrhage etiology, Humans, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Rectal Diseases etiology, Chromosomes, Human, Pair 11, Gastrointestinal Hemorrhage genetics, Genome-Wide Association Study, Prostatic Neoplasms radiotherapy, Rectal Diseases genetics
Abstract

Background and Purpose: Rectal bleeding can occur following radiotherapy for prostate cancer and negatively impacts quality of life for cancer survivors. Treatment and clinical factors do not fully predict rectal bleeding, and genetic factors may be important., Materials and Methods: A genome-wide association study (GWAS) was performed to identify SNPs associated with the development of late rectal bleeding following radiotherapy for prostate cancer. Logistic regression was used to test the association between 614,453 SNPs and rectal bleeding in a discovery cohort (79 cases, 289 controls), and top-ranking SNPs were tested in a replication cohort (108 cases, 673 controls) from four independent sites., Results: rs7120482 and rs17630638, which tag a single locus on chromosome 11q14.3, reached genome-wide significance for association with rectal bleeding (combined p-values 5.4×10(-8) and 6.9×10(-7) respectively). Several other SNPs had p-values trending toward genome-wide significance, and a polygenic risk score including these SNPs shows a strong rank-correlation with rectal bleeding (Sommers' d=5.0×10(-12) in the replication cohort)., Conclusions: This GWAS identified novel genetic markers of rectal bleeding following prostate radiotherapy. These findings could lead to the development of a predictive assay to identify patients at risk for this adverse treatment outcome so that dose or treatment modality could be modified., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)

Published
2013
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