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151 results on '"Blagosklonov, Oleg"'

1. Circulating cell-free DNA in patients with alveolar echinococcosis

Author

Felix, Sophie, Heyd, Bruno, Mantion, Georges, Di Martino, Vincent, Montange, Damien, Vanlemmens, Claire, Vuitton, Dominique Angèle, Weil-Verhoeven, Delphine, Chavanet, Pascal, Dalle, Frédéric, Gohier, Sandrine, Minello, Anne, Piroth, Lionel, Dumortier, Jérôme, Mabrut, Jean-Yves, Wallon, Martine, Frentiu, Emilia, Machouart, Marie, Watelet, Jérôme, Chemla, Cathy, Feron, Thomas, Heurge-Berlot, Alexandra, Sommacale, Daniele, Thiefin, Gerard, Abou-Bacar, Ahmed, Brunet, Julie, Candolfi, Ermano, Hansmann, Yves, Lefebvre, Nicolas, Baraquin, Alice, Hervouet, Eric, Richou, Carine, Flori, Pierre, Peixoto, Paul, Azizi, Amel, Delabrousse, Eric, Blagosklonov, Oleg, Umhang, Gerald, Bresson-Hadni, Solange, Valot, Benoit, and Grenouillet, Frédéric

Published
2018
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5. Diagnostic de l’échinococcose alvéolaire

Author

Bresson-Hadni, Solange, Grenouillet, Frédéric, Chauchet, Adrien, Richou, Carine, Knapp, Jenny, Delabrousse, Éric, Adrian-Félix, Sophie, Blagosklonov, Oleg, Vuitton, Dominique-Angèle, and Millon, Laurence

Published
2014
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13. Echinococcus metacestode: in search of viability markers

Author

Gottstein Bruno, Wang Junhua, Blagosklonov Oleg, Grenouillet Frédéric, Millon Laurence, Vuitton Dominique A., and Müller Norbert

Subjects
Echinococcus multilocularis, Alveolar echinococcosis, Surgery, Medication, Follow-up, Em18, Em2, FDG-PET, Infectious and parasitic diseases, RC109-216
Abstract

Epidemiological studies have demonstrated that most humans infected with Echinococcus spp. exhibit resistance to disease. When infection leads to disease, the parasite is partially controlled by host immunity: in case of immunocompetence, the normal alveolar echinococcosis (AE) or cystic echinococcosis (CE) situation, the metacestode grows slowly, and first clinical signs appear years after infection; in case of impaired immunity (AIDS; other immunodeficiencies), uncontrolled proliferation of the metacestode leads to rapidly progressing disease. Assessing Echinococcus multilocularis viability in vivo following therapeutic interventions in AE patients may be of tremendous benefit when compared with the invasive procedures used to perform biopsies. Current options are F18-fluorodeoxyglucose-positron emission tomography (FDG-PET), which visualizes periparasitic inflammation due to the metabolic activity of the metacestode, and measurement of antibodies against recEm18, a viability-associated protein, that rapidly regresses upon metacestode inactivation. For Echinococcus granulosus, similar prognosis-associated follow-up parameters are still lacking but a few candidates may be listed. Other possible markers include functional and diffusion-weighted Magnetic Resonance Imaging (MRI), and measurement of products from the parasite (circulating antigens or DNA), and from the host (inflammation markers, cytokines, or chemokines). Even though some of them have been promising in pilot studies, none has been properly validated in an appropriate number of patients until now to be recommended for further use in clinical settings. There is therefore still a need to develop reliable tools for improved viability assessment to provide the sufficient information needed to reliably withdraw anti-parasite benzimidazole chemotherapy, and a basis for the development of new alternative therapeutic tools.

Published
2014
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14. Innovation in hepatic alveolar echinococcosis imaging: best use of old tools, and necessary evaluation of new ones

Author

Liu Wenya, Delabrousse Éric, Blagosklonov Oleg, Wang Jing, Zeng Hongchun, Jiang Yi, Wang Jian, Qin Yongde, Vuitton Dominique Angèle, and Wen Hao

Subjects
Hepatic Alveolar Echinococcosis, Computed Tomography, Magnetic Resonance Imaging, FluoroDeoxyGlucose-Positron Emission Tomography, Functional evaluation, Innovation techniques, Infectious and parasitic diseases, RC109-216
Abstract

Hepatic Alveolar Echinococcosis (HAE), caused by larvae of Echinococcus multilocularis, is a rare but potentially lethal parasitic disease. The first diagnostic suspicion is usually based on hepatic ultrasound exam performed because of abdominal symptoms or in the context of a general checkup; HAE diagnosis may thus also be an incidental finding on imaging. The next step should be Computed Tomography (CT) or Magnetic Resonance Imaging (MRI). They play an important role in the initial assessment of the disease; with chest and brain imaging, they are necessary to assess the PNM stage (parasite lesion, neighboring organ invasion, metastases) of a patient with AE. Performed at least yearly, they also represent key exams for long-term follow-up after therapeutic interventions. Familiarity of radiologists with HAE imaging findings, especially in the endemic regions, will enable earlier diagnosis and more effective treatment. Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) is currently considered to be the only noninvasive, albeit indirect, tool for the detection of metabolic activity in AE. Delayed acquisition of images (3 hrs after FDG injection) enhances its sensitivity for the assessment of lesion metabolism and its reliability for the continuation/withdrawal of anti-parasite treatment. However, sophisticated equipment and high cost widely limit PET/CT use for routine evaluation. Preliminary studies show that new techniques, such as contrast-enhanced ultrasound (US), Dual Energy CT or Spectral CT, and Diffusion-Weighted MRI, might also be useful in detecting the blood supply and metabolism of lesions. However, they cannot be recommended before further evaluation of their reliability in a larger number of patients with a variety of locations and stages of AE lesions.

Published
2014
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15. 30-yr course and favorable outcome of alveolar echinococcosis despite multiple metastatic organ involvement in a non-immune suppressed patient

Author

Bardonnet Karine, Vuitton Dominique A, Grenouillet Frédéric, Mantion Georges A, Delabrousse Eric, Blagosklonov Oleg, Miguet Jean-Philippe, and Bresson-Hadni Solange

Subjects
Therapeutics. Pharmacology, RM1-950, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Abstract We report the 30-yr history of a well-documented human case of alveolar echinococcosis, with a lung lesion at presentation followed by the discovery of a liver lesion, both removed by surgery. Subsequently, within the 13 years following diagnosis, metastases were disclosed in eye, brain and skull, as well as additional lung lesions. This patient had no immune suppression, and did not have the genetic background known to predispose to severe alveolar echinococcosis; it may thus be hypothesized that iterative multi-organ involvement was mostly due to the poor adherence to benzimidazole treatment for the first decade after diagnosis. Conversely, after a new alveolar echinococcosis recurrence was found in the right lung in 1994, the patient accepted to take albendazole continuously at the right dosage. After serology became negative and a fluoro-deoxy-glucose-Positron Emission Tomography performed in 2005 showed a total regression of the lesions in all organs, albendazole treatment could be definitively withdrawn. In 2011, the fluoro-deoxy-glucose-Positron Emission Tomography showed a total absence of parasitic metabolic activity and the patient had no clinical symptoms related to alveolar echinococcosis. The history of this patient suggests that multi-organ involvement and alveolar echinococcosis recurrence over time may occur in non-immune suppressed patients despite an apparently “radical” surgery. Metastatic dissemination might be favored by a poor adherence to chemotherapy. Combined surgery and continuous administration of albendazole at high dosage may allow alveolar echinococcosis patients to survive more than 30 years after diagnosis despite multi-organ involvement.

Published
2013
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17. Circulating cell-free DNA in patients with alveolar echinococcosis

Author

Baraquin, Alice, primary, Hervouet, Eric, additional, Richou, Carine, additional, Flori, Pierre, additional, Peixoto, Paul, additional, Azizi, Amel, additional, Delabrousse, Eric, additional, Blagosklonov, Oleg, additional, Umhang, Gerald, additional, Bresson-Hadni, Solange, additional, Valot, Benoit, additional, Grenouillet, Frédéric, additional, Felix, Sophie, additional, Heyd, Bruno, additional, Mantion, Georges, additional, Di Martino, Vincent, additional, Montange, Damien, additional, Vanlemmens, Claire, additional, Vuitton, Dominique Angèle, additional, Weil-Verhoeven, Delphine, additional, Chavanet, Pascal, additional, Dalle, Frédéric, additional, Gohier, Sandrine, additional, Minello, Anne, additional, Piroth, Lionel, additional, Dumortier, Jérôme, additional, Mabrut, Jean-Yves, additional, Wallon, Martine, additional, Frentiu, Emilia, additional, Machouart, Marie, additional, Watelet, Jérôme, additional, Chemla, Cathy, additional, Feron, Thomas, additional, Heurge-Berlot, Alexandra, additional, Sommacale, Daniele, additional, Thiefin, Gerard, additional, Abou-Bacar, Ahmed, additional, Brunet, Julie, additional, Candolfi, Ermano, additional, Hansmann, Yves, additional, and Lefebvre, Nicolas, additional

Published
2018
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19. Increased Incidence and Characteristics of Alveolar Echinococcosis in Patients With Immunosuppression-Associated Conditions

Author

Sondag Daniel, Cusenier Bernadette, Alby-Lepresle Blandine, Delattre Jean Francois, Gerard Alain, Samuel Didier, Farges Olivier, Dominique A. Vuitton, Letranchant Lorraine, Jenny Knapp, Watelet Jérôme, Brientini Marie Pascale, Bresson-Hadni Solange, Guillaud Olivier, Hillon Patrick, Cappelle Sylvie, Piarroux Martine, Debruyne Monique, Vuitton Dominique Angèle, Valmary-Degano Séverine, Godet Claire, Adrien Chauchet, Beytout Jean, Hansmann Yves, Laurence Millon, Besancenot Jean François, Li Véronique, Contreras Remy, Raoul Francis, Vitrat Virginie, Eric Delabrousse, Partensky Christian, Koch Stéphane, Mantion Georges, Evrard Philippe, Delabrousse Eric, Carine Richou, Dumortier Jérôme, Raabe Jean-Jacques, Remy Contreras, Wallon Martine, Beurton-Chataigner Isabelle, Abou-Bacar Ahmed, Di Martino Vincent, Chemla Cathy, Heyd Bruno, Machouart Marie, Audet Maxime, Richou Carine, Oleg Blagosklonov, Vanlemmens Claire, Minello Anne, Bardonnet Karine, Giraudoux Patrick, Felix Sophie, Frédéric Grenouillet, Blagosklonov Oleg, Abergel Armand, Vuitton Lucine, Rabodonirina Meja, Faure Odile, Charlotte Dentan, Guerin Bruno, Grenouillet Frédéric, Knapp Jenny, Lefebvre Nicolas, Johann Marc, Solange Bresson-Hadni, Cambon Monique, Chatelain Eric, Eric Deconinck, Letoublon Christian, Prost Patricia, Bartholomot Brigitte, Vincent Di Martino, Millon Laurence, Service d'hématologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté (UFC), Service d'hépatologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Service de Médecine nucléaire, biophysique, isotopes [CHRU Besançon], Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -hopital Jean Minjoz, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Hôpital Jean Minjoz, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Université de Franche-Comté ( UFC ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Jean Minjoz-Université de Franche-Comté ( UFC ), Dept. of Nucl. Med., Jean Minjoz Univ. Hosp., Besancon, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), and Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC )

Subjects
Male, Microbiology (medical), Echinococcosis, Hepatic, medicine.medical_specialty, Delayed Diagnosis, medicine.medical_treatment, Echinococcus multilocularis, Risk Assessment, Gastroenterology, [ SDV.EE.SANT ] Life Sciences [q-bio]/Ecology, environment/Health, Albendazole, Serology, Immunocompromised Host, Echinococcosis, Risk Factors, Internal medicine, medicine, Humans, Abscess, Aged, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, biology, business.industry, Incidence, Incidence (epidemiology), Immunosuppression, Middle Aged, medicine.disease, biology.organism_classification, 3. Good health, Surgery, Infectious Diseases, Concomitant, Female, business, Liver abscess, medicine.drug
Abstract

International audience; BACKGROUND: An increased incidence of alveolar echinococcosis (AE) in patients with immunosuppression (IS) has been observed; our aim was to study this association and its characteristics. METHODS: Fifty AE cases with IS-associated conditions (ISCs) before or at AE diagnosis were collected from the French AE registry (1982-2012, 509 cases). There were 30 cancers, 9 malignant hematological disorders, 14 chronic inflammatory diseases, 5 transplants, and 1 case of AIDS; 9 patients had ≥2 ISCs. Characteristics of the 42 IS/AE cases and the 187 non-IS/AE cases diagnosed during the period 2002-2012 were statistically compared. RESULTS: There was a significant increase in IS/AE cases over time. Risk factors did not differ between IS/AE and non-IS/AE patients. However, AE was more frequently an incidental finding (78% vs 42%) and was diagnosed at earlier stages (41% vs 23%) in IS/AE than in non-IS/AE patients. Serology was more often negative (14% vs 1%) and treatment efficacy was better (51% regression after 1-year treatment vs 27%) in IS/AE patients. All IS/AE patients but 7 took IS drugs; 7 received biotherapeutic agents. When not concomitant, AE occurred in IS patients within a 48-month median time period. Atypical presentation and abscess-, hemangioma-, and metastasis-like images delayed AE diagnosis in 50% of IS/AE patients, resulting in inappropriate treatment. Liver images obtained for 15 patients 1-5 years before diagnosis showed no AE lesions. Albendazole efficacy was good, but 19 of 48 treated patients experienced side effects. CONCLUSIONS: Patients with immunosuppression are at increased risk for occurrence, delayed diagnosis, and progression of AE.

Published
2014
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20. Hints for control of infection in unique extrahepatic vertebral alveolar echinococcosis

Author

Faucher, Jean-François, primary, Descotes-Genon, Cécile, additional, Hoen, Bruno, additional, Godard, Joël, additional, Félix, Sophie, additional, Aubry, Sébastien, additional, Blagosklonov, Oleg, additional, Grenouillet, Frédéric, additional, Brientini, Marie-Pascale, additional, Richou, Carine, additional, Bresson-Hadni, Solange, additional, and Chirouze, Catherine, additional

Published
2016
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23. Interobserver agreement of qualitative analysis and tumor delineation of FMISO and FLT PET-images in lung cancer

Author

Thureau, Sébastien, Chaumet Riffaud, Philippe, Modzelewski, Romain, Fernandez, Philippe, Tessonnier, Laurent, Vervueren, Laurent, Cachin, Florent, Berriolo-Riedinger, Alina, Olivier, Pierre, Kolesnikov-Gauthier, Hélène, Blagosklonov, Oleg, Bridji, Boumediene, Devillers, Anne, Collombier, Laurent, Courbon, Frederic, Gremillet, Eric, Houzard, Claire, Caignon, Jean-Marc, Roux, Julie, Aide, Nicolas, Brenot-Rossi, Isabelle, Doyeux, Kaya, Dubray, Bernard, Vera, Pierre, Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Service de Biophysique et de Médecine Nucléaire, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de Médecine nucléaire, biophysique, isotopes [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Département de médecine nucléaire [Rennes], CRLCC Eugène Marquis (CRLCC), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Claudius Regaud, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Dept. of Nucl. Med., Jean Minjoz Univ. Hosp., Besancon, Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), CRLCC Institut Claudius Regaud, Centre Régional de Lutte contre le Cancer François Baclesse (CRLC François Baclesse ), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), and Breton, Céline

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013

24. Echinococcoe alvéolaire

Author

Bresson-Hadni , Solange, Chauchet , Adrien, Vuitton , D.A., Frédéric , Grenouillet, Knapp , J., Richou , C., Delabrousse , Eric, Blagosklonov , Oleg, Koch , Stéphane, Mantion , Georges André, Heyd , Bruno, Millon , Laurence, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service d'hématologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté (UFC), Service d'oncologie chirurgicale, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -hopital Jean Minjoz, Hôpital Jean Minjoz, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), and Université de Franche-Comté ( UFC )

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, échinococcose alvéolaire, résection chirurgicale, transplantation hépatique, infection opportuniste, benzimidazolés, ComputingMilieux_MISCELLANEOUS, [ SDV.EE.SANT ] Life Sciences [q-bio]/Ecology, environment/Health, radiologie et endoscopie interventionnelles, echinococcus multiloculoris
Abstract

International audience

Published
2010

25. Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice

Author

Wang, Junhua, primary, Vuitton, Dominique A., additional, Müller, Norbert, additional, Hemphill, Andrew, additional, Spiliotis, Markus, additional, Blagosklonov, Oleg, additional, Grandgirard, Denis, additional, Leib, Stephen L., additional, Shalev, Itay, additional, Levy, Gary, additional, Lu, Xiaomei, additional, Lin, Renyong, additional, Wen, Hao, additional, and Gottstein, Bruno, additional

Published
2015
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26. Deletion of fibrinogen-like protein 2, a novel CD4+ CD25+ Treg effector molecule, leads to improved control of Echinococcus mutilocularis infection (MPF7P.718)

Author

Lin, Renyong, primary, Wang, Junhua, additional, Vuitton, Dominique, additional, Müller, Norbert, additional, Blagosklonov, Oleg, additional, Grandgirard, Denis, additional, Leib, Stephen, additional, Shalev, Itay, additional, Levy, Gary, additional, Lu, Xiaomei, additional, Spiliotis, Markus, additional, wen, Hao, additional, and Gottstein, Bruno, additional

Published
2015
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27. Diagnosis and treatment of alveolar echinococcosis of the liver in immunocompromised patients

Author

Chauchet , Adrien, Richou , C., Grenouillet , Frédéric, Vuitton , Dominique Angèle, Blagosklonov , Oleg, Dupond , Jean-Louis, Delabrousse , Eric, Di Martino , Vincent, Deconinck , Eric, Millon , Laurence, Mantion , Georges André, Bresson-Hadni , Solange, Hôpital Jean Minjoz, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté ( UFC ), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Dept. of Nucl. Med., Jean Minjoz Univ. Hosp., Besancon, Agents pathogènes et inflammation - UFC (EA 4266) ( API ), Service greffe de moelle osseuse, Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Diderot - Paris 7 ( UPD7 ) -Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Service de Médecine nucléaire, biophysique, isotopes [CHRU Besançon], Agents pathogènes et inflammation - UFC (EA 4266) (API), Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)

Subjects
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, ComputingMilieux_MISCELLANEOUS, [ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Abstract

International audience

Published
2010

28. [Alveolar echinococcosis: from an incurable rural disease to a controlled urban infection]

Author

Vuitton, Dominique Angèle, Bresson-Hadni, Solange, Giraudoux, Patrick, Bartholomot, Brigitte, Laplante, Jean-Jacques, Delabrousse, Eric, Blagosklonov, Oleg, Mantion, Georges, WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté ( UFC ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ), WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, SERF Unit, Mutualité sociale agricole de Franche-Comté, Mutualité sociale agricole, Dept. of Nucl. Med., Jean Minjoz Univ. Hosp., Besancon, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Service de Médecine nucléaire, biophysique, isotopes [CHRU Besançon], and Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)

Subjects
MESH: Urban Health, Endemic Diseases, Aftercare, Rural Health, MESH : Echinococcus multilocularis, MESH : Early Diagnosis, MESH: Magnetic Resonance Imaging, MESH: Aftercare, MESH: Risk Factors, MESH: Early Diagnosis, Risk Factors, Zoonoses, MESH : Rural Health, MESH : Tomography, X-Ray Computed, Mass Screening, MESH: Animals, MESH: Anticestodal Agents, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, [ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, MESH: Echinococcosis, Hepatic, Magnetic Resonance Imaging, MESH : Risk Factors, MESH: Positron-Emission Tomography, MESH: China, Europe, MESH: Endemic Diseases, France, MESH: Tomography, X-Ray Computed, MESH: Zoonoses, MESH : Endemic Diseases, MESH : Albendazole, China, Echinococcosis, Hepatic, MESH : Europe, Albendazole, MESH : Zoonoses, MESH : Magnetic Resonance Imaging, MESH: Albendazole, Animals, Humans, MESH : China, MESH: Mass Screening, MESH : France, MESH: Echinococcus multilocularis, MESH : Mass Screening, MESH: Humans, MESH : Urban Health, MESH : Anticestodal Agents, MESH : Humans, Urban Health, Anticestodal Agents, MESH : Positron-Emission Tomography, MESH: Rural Health, MESH: France, Early Diagnosis, Positron-Emission Tomography, MESH : Aftercare, Echinococcus multilocularis, MESH: Europe, MESH : Animals, Tomography, X-Ray Computed, MESH : Echinococcosis, Hepatic
Abstract

International audience; Human alveolar echinococcosis is a parasitic zoonosis with intermediate (rodents and small lagomorphs) and final (carnivores) hosts. The latter can transmit the parasite to humans, by their feces, which are contaminated by the oncospheres of Echinococcus multilocularis, the larvae of which develop in the liver like a slow cancer. Political, socioeconomic, and ecological factors can affect the intermediate and final hosts and thus influence the long-term emergence and stability of endemic areas. The past 20 years have been marked by: Epidemiologic changes: discovery of an endemic area in China, the largest in the world; extension of the European endemic range to the east and north; extension of the French endemic range to the west and south; and the settlement of contaminated foxes in urban centers, which will modify the populations at risk over time. Progress in diagnosis: initial use of liver ultrasound to screen for asymptomatic disease; value of magnetic resonance imaging to confirm diagnosis and assess extension of disease before beginning treatment; mastery of immunological and genetic diagnosis; and the introduction of positron emission tomography combined with computed tomography to assess the functional activity of the lesions and monitor treatment. Consensus has defined the main directions of a multidisciplinary treatment approach: radical liver resection when possible; avoidance of palliative surgical procedures; use of interventional radiology or endoscopy to treat biliary and vascular complications, whenever possible; consideration of liver transplantation only when all other treatment possibilities have been exhausted; and treatment of all patients, without exception, by albendazole for at least two years after radical surgery and long term (at least several years) in other cases. In France, survival and quality of life have improved very substantially, due to earlier diagnosis, clinical classification of cases, and rigorous follow-up as part of the FrancEchino network. Better understanding of the immunological and immunogenetic mechanisms that underlie the course of disease may open up the possibility of immunomodulation that could replace or round out the current treatments. These are far from satisfactory, in view of the constraints of prolonged, most often life-long treatment by benzimidazoles and their side effects.

Published
2010
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29. Em+ Elisa: a serological test able to predict long term outcome in inoperable alveolar echinococcosis patients under benzimidazole therapy

Author

Richou, Carine, Grenouillet, Frédéric, Delabrousse, Eric, Blagosklonov, Oleg, Ma, Shu Mei, Millon, Laurence, Mantion, Georges André, Di Martino, Vincent, Bresson-Hadni, Solange, WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Service de Médecine nucléaire, biophysique, isotopes [CHRU Besançon], Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté ( UFC ), Hôpital Jean Minjoz, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Dept. of Nucl. Med., Jean Minjoz Univ. Hosp., Besancon, and Agents pathogènes et inflammation - UFC (EA 4266) ( API )

Subjects
[ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, ComputingMilieux_MISCELLANEOUS, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Abstract

International audience

Published
2009

30. Towards 'à la carte' management of patients with inoperable alveolar echinococcosis of the liver: usefullness of a compined follow-up with specific serology, CT-scan and PET-CT

Author

Bresson-Hadni , Solange, Crouzet , Julien, Blagosklonov , Oleg, Grenouillet , Frédéric, Thevenot , Thierry, Piarroux , Renaud, Mantion , Georges, Miguet , Jean-Philippe, WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Service de Médecine nucléaire, biophysique, isotopes [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Université de Franche-Comté ( UFC ), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Dept. of Nucl. Med., Jean Minjoz Univ. Hosp., Besancon, and Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon )

Subjects
[ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, ComputingMilieux_MISCELLANEOUS, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Abstract

International audience

Published
2006

31. Albendazole therapy for recurrent alveolar echinococcosis after liver transplantation may be parasitocidal despite immunosuppression: usefulness of PET-CT and new serological markers for the follow up

Author

Bresson-Hadni, Solange, Crouzet, Julien, Blagosklonov, Oleg, Sako, Yasuhito, Grenouillet, Frédéric, Delabrousse, Eric, Ito, Akira, Minello, Anne, Piarroux, Renaud, Vuitton, Dominique-Angèle, Mantion, Georges, WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté ( UFC ), Dept. of Nucl. Med., Jean Minjoz Univ. Hosp., Besancon, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Asahikawa Medical College, Dept of Parasitology ( AMC ), Asahikawa Medical College, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Parasitology Dept AMC, Anasahikawa Medical College, Service d'Hépato-Gastro-Entérologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de Médecine nucléaire, biophysique, isotopes [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Asahikawa Medical College, Dept of Parasitology (AMC), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)

Subjects
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, ComputingMilieux_MISCELLANEOUS, [ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Abstract

International audience

Published
2006

36. Increased Incidence and Characteristics of Alveolar Echinococcosis in Patients With Immunosuppression-Associated Conditions

Author

Chauchet, Adrien, primary, Grenouillet, Frédéric, additional, Knapp, Jenny, additional, Richou, Carine, additional, Delabrousse, Eric, additional, Dentan, Charlotte, additional, Millon, Laurence, additional, Di Martino, Vincent, additional, Contreras, Remy, additional, Deconinck, Eric, additional, Blagosklonov, Oleg, additional, Vuitton, Dominique A., additional, Bresson-Hadni, Solange, additional, Virginie, Vitrat, additional, Karine, Bardonnet, additional, Brigitte, Bartholomot, additional, Isabelle, Beurton-Chataigner, additional, Oleg, Blagosklonov, additional, Solange, Bresson-Hadni, additional, Pascale, Brientini Marie, additional, Sylvie, Cappelle, additional, Remy, Contreras, additional, Eric, Delabrousse, additional, Vincent, Di Martino, additional, Philippe, Evrard, additional, Sophie, Felix, additional, Patrick, Giraudoux, additional, Frédéric, Grenouillet, additional, Bruno, Heyd, additional, Séverine, Valmary-Degano, additional, Jenny, Knapp, additional, Stéphane, Koch, additional, Georges, Mantion, additional, Laurence, Millon, additional, Francis, Raoul, additional, Carine, Richou, additional, Claire, Vanlemmens, additional, Angèle, Vuitton Dominique, additional, Lucine, Vuitton, additional, Patricia, Prost, additional, Claire, Godet, additional, Armand, Abergel, additional, Jean, Beytout, additional, Monique, Cambon, additional, François, Besancenot Jean, additional, Bernadette, Cusenier, additional, Patrick, Hillon, additional, Anne, Minello, additional, Odile, Faure, additional, Christian, Letoublon, additional, Jérôme, Dumortier, additional, Olivier, Guillaud, additional, Christian, Partensky, additional, Meja, Rabodonirina, additional, Martine, Wallon, additional, Martine, Piarroux, additional, Eric, Chatelain, additional, Marc, Johann, additional, Jean-Jacques, Raabe, additional, Daniel, Sondag, additional, Alain, Gerard, additional, Lorraine, Letranchant, additional, Marie, Machouart, additional, Jérôme, Watelet, additional, Olivier, Farges, additional, Didier, Samuel, additional, Cathy, Chemla, additional, Francois, Delattre Jean, additional, Bruno, Guerin, additional, Monique, Debruyne, additional, Ahmed, Abou-Bacar, additional, Maxime, Audet, additional, Yves, Hansmann, additional, Nicolas, Lefebvre, additional, Véronique, Li, additional, and Blandine, Alby-Lepresle, additional

Published
2014
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38. Transcriptional Profiles of Cytokine/Chemokine Factors of Immune Cell-Homing to the Parasitic Lesions: A Comprehensive One-Year Course Study in the Liver of E. multilocularis-Infected Mice

Author

Wang, Junhua, primary, Lin, Renyong, additional, Zhang, Wenbao, additional, Li, Liang, additional, Gottstein, Bruno, additional, Blagosklonov, Oleg, additional, Lü, Guodong, additional, Zhang, Chuangshan, additional, Lu, Xiaomei, additional, Vuitton, Dominique A., additional, and Wen, Hao, additional

Published
2014
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40. Interobserver Agreement of Qualitative Analysis and Tumor Delineation of 18F-Fluoromisonidazole and 3′-Deoxy-3′-18F-Fluorothymidine PET Images in Lung Cancer

Author

Thureau, Sébastien, primary, Chaumet-Riffaud, Philippe, additional, Modzelewski, Romain, additional, Fernandez, Philippe, additional, Tessonnier, Laurent, additional, Vervueren, Laurent, additional, Cachin, Florent, additional, Berriolo-Riedinger, Alina, additional, Olivier, Pierre, additional, Kolesnikov-Gauthier, Hélène, additional, Blagosklonov, Oleg, additional, Bridji, Boumediene, additional, Devillers, Anne, additional, Collombier, Laurent, additional, Courbon, Fréderic, additional, Gremillet, Eric, additional, Houzard, Claire, additional, Caignon, Jean Marc, additional, Roux, Julie, additional, Aide, Nicolas, additional, Brenot-Rossi, Isabelle, additional, Doyeux, Kaya, additional, Dubray, Bernard, additional, and Vera, Pierre, additional

Published
2013
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