28,152 results on '"Blair P"'
Search Results
2. Family Involvement in the Care of Hospitalized Older Adults: Protocol for a Qualitative Evidence Synthesis
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Judith B Vick, Blair P Golden, Sarah Cantrell, Melissa Louise Harris-Gersten, Mollie R Selmanoff, Susan Nicole Hastings, Tolu O Oyesanya, Karen M Goldstein, and Courtney Van Houtven
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Medicine ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
BackgroundOlder adults are frequently hospitalized. Family involvement during these hospitalizations is incompletely characterized in the literature. ObjectiveThis study aimed to better understand how families are involved in the care of hospitalized older adults and develop a conceptual model describing the phenomenon of family involvement in the care of hospitalized older adults. MethodsWe describe the protocol of a qualitative evidence synthesis (QES), a systematic review of qualitative studies. We chose to focus on qualitative studies given the complexity and multifaceted nature of family involvement in care, a type of topic best understood through qualitative inquiry. The protocol describes our process of developing a research question and eligibility criteria for inclusion in our QES based on the SPIDER (Sample, Phenomenon of Interest, Design, Evaluation, and Research type) tool. It describes the development of our search strategy, which was used to search MEDLINE (via Ovid), Embase (via Elsevier), PsycINFO (via Ovid), and CINAHL Complete (via EBSCO). Title and abstract screening and full-text screening will occur sequentially. Purposive sampling may be used depending on the volume of studies identified as eligible for inclusion during our screening process. Descriptive data regarding included individual studies will be extracted and summarized in tables. The results from included studies will be synthesized using qualitative methods and used to develop a conceptual model. The conceptual model will be presented to community members via engagement panels for further refinement. ResultsAs of September 2023, we have assembled a multidisciplinary team including physicians, nurses, health services researchers, a librarian, a social worker, and a health economist. We have finalized our search strategy and executed the search, yielding 8862 total citations. We are currently screening titles and abstracts and anticipate that full-text screening, data extraction, quality appraisal, and synthesis will be completed by summer of 2024. Conceptual model development will then take place with community engagement panels. We anticipate submitting our manuscript for publication in the fall of 2024. ConclusionsThis paper describes the protocol for a QES of family involvement in the care of hospitalized older adults. We will use identified themes to create a conceptual model to inform further intervention development and policy change. Trial RegistrationPROSPERO 465617; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023465617 International Registered Report Identifier (IRRID)PRR1-10.2196/53255
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- 2024
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3. Defining a Danger Zone for Iatrogenic Long Thoracic Nerve Injury in Gender-Affirming Mastectomy
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Kelsey Isbester, MD, Peter Ferrin, MD, Ellie Moeller, MD, Nicholas Bene, MD, and Blair Peters, MD
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Surgery ,RD1-811 - Published
- 2024
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4. Promoting Public Engagement in Interdisciplinary Biological Systems Education by Leveraging American Sports-Inspired Bracket Contests on Social Media and Web
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Phillip R. Myer, Susan Blair, Katie M. Mason, Elizabeth A. Shepherd, Blair C. Downey, Kyle J. McLean, Troy N. Rowan, Elizabeth A. Eckelkamp, F. Neal Schrick, and Jennie L. Zambito Ivey
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The complexity of modern biology poses challenges in fostering interdisciplinary understanding, particularly between practicing scientists and the public. Furthermore, scientists often lack formal training in science communication, despite various motivations to engage the public. The science literacy of the public in the biological sciences can also vary across socio-economic and cultural backgrounds. Leveraging popular culture and informal learning practices to promote active learning offers promising avenues to enhance public understanding of biological systems. Organized sports hold collective recognition across various communities and cultures, serving as a means to bring people together. Notably, the NCAA March Madness event holds widespread national and international popularity, presenting an opportunity to laterally apply this concept to promote science communication within STEM and biology education. An educational social media and web-based contest tool was developed integrating NCAA-inspired brackets with animal biological systems concepts. The tool featured tournament-style matchups based on animal biological systems, interesting animal facts, and a voting system, all housed within a user-friendly interface. To encourage regular user access to the tool, graphic designs were developed for all social media posts to aid in visual recruitment to the voting website. Based on online metrics, the use of social media garnered repeat users across both the public and educators. The latter noted the tool's simplicity and informative content. Application of this social media and web-based bracket contest tool, which leverages informal settings for active learning for use in biology education, can foster science communication to engage audiences, improve comprehension, and promote interdisciplinary biology education.
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- 2024
5. 32. Urologic Outcomes After Big Ben Method Phalloplasty
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Jens U. Berli, MD, Alvin Annen, MD, Isabel Cylinder, MD, Peter Ferrin, MD, carter buuck, bs, and Blair Peters, MD
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Surgery ,RD1-811 - Published
- 2024
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6. Factors Affecting the Choice to Forgo Nipple Grafts in Gender-Affirming Chest Surgery
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Peter Ferrin, Ezra Pua, Kelsey Isbester, MD, and Blair Peters, MD
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Surgery ,RD1-811 - Published
- 2024
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7. Hydraulic Flushing of Sediment in Reservoirs: Best Practices of Numerical Modeling
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Yong G. Lai, Jianchun Huang, and Blair P. Greimann
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reservoir sedimentation ,sediment flushing ,sediment sluicing ,hydraulic flushing ,numerical model ,reservoir sustainability ,Thermodynamics ,QC310.15-319 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
This article provides a comprehensive review and best practices for numerically simulating hydraulic flushing for reservoir sediment management. Three sediment flushing types are discussed: drawdown flushing, pressure flushing, and turbidity current venting. The need for reservoir sediment management and the current practices are reviewed. Different hydraulic drawdown types are described in terms of the basic physical processes involved as well as the empirical/analytical assessment tools that may be used. The primary focus has been on the numerical modeling of various hydraulic flushing options. Three model categories are reviewed: one-dimensional (1D), two-dimensional (2D) depth-averaged or layer-averaged, and three-dimensional (3D) computational fluid dynamics (CFD) models. General guidelines are provided on how to select a proper model given the characteristics of the reservoir and the flushing method, as well as specific guidelines for modeling. Case studies are also presented to illustrate the guidelines.
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- 2024
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8. Search for gravitational waves emitted from SN 2023ixf
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The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abac, A. G., Abbott, R., Abouelfettouh, I., Acernese, F., Ackley, K., Adhicary, S., Adhikari, N., Adhikari, R. X., Adkins, V. K., Agarwal, D., Agathos, M., Abchouyeh, M. Aghaei, Aguiar, O. D., Aguilar, I., Aiello, L., Ain, A., Akutsu, T., Albanesi, S., Alfaidi, R. A., Al-Jodah, A., Alléné, C., Allocca, A., Al-Shammari, S., Altin, P. A., Alvarez-Lopez, S., Amato, A., Amez-Droz, L., Amorosi, A., Amra, C., Ananyeva, A., Anderson, S. B., Anderson, W. G., Andia, M., Ando, M., Andrade, T., Andres, N., Andrés-Carcasona, M., Andrić, T., Anglin, J., Ansoldi, S., Antelis, J. M., Antier, S., Aoumi, M., Appavuravther, E. Z., Appert, S., Apple, S. K., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Argianas, L., Aritomi, N., Armato, F., Arnaud, N., Arogeti, M., Aronson, S. M., Ashton, G., Aso, Y., Assiduo, M., Melo, S. Assis de Souza, Aston, S. M., Astone, P., Attadio, F., Aubin, F., AultONeal, K., Avallone, G., Babak, S., Badaracco, F., Badger, C., Bae, S., Bagnasco, S., Bagui, E., Baier, J. G., Baiotti, L., Bajpai, R., Baka, T., Ball, M., Ballardin, G., Ballmer, S. W., Banagiri, S., Banerjee, B., Bankar, D., Baral, P., Barayoga, J. C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartoletti, A. M., Barton, M. A., Bartos, I., Basak, S., Basalaev, A., Bassiri, R., Basti, A., Bates, D. E., Bawaj, M., Baxi, P., Bayley, J. C., Baylor, A. C., Baynard II, P. A., Bazzan, M., Bedakihale, V. M., Beirnaert, F., Bejger, M., Belardinelli, D., Bell, A. S., Benedetto, V., Benoit, W., Bentley, J. D., Yaala, M. Ben, Bera, S., Berbel, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Beroiz, M., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bevins, N., Bhandare, R., Bhardwaj, U., Bhatt, R., Bhattacharjee, D., Bhaumik, S., Bhowmick, S., Bianchi, A., Bilenko, I. A., Billingsley, G., Binetti, A., Bini, S., Birnholtz, O., Biscoveanu, S., Bisht, A., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blagg, L. A., Blair, C. D., Blair, D. G., Bobba, F., Bode, N., Boileau, G., Boldrini, M., Bolingbroke, G. N., Bolliand, A., Bonavena, L. D., Bondarescu, R., Bondu, F., Bonilla, E., Bonilla, M. S., Bonino, A., Bonnand, R., Booker, P., Borchers, A., Boschi, V., Bose, S., Bossilkov, V., Boudart, V., Boudon, A., Bozzi, A., Bradaschia, C., Brady, P. R., Braglia, M., Branch, A., Branchesi, M., Brandt, J., Braun, I., Breschi, M., Briant, T., Brillet, A., Brinkmann, M., Brockill, P., Brockmueller, E., Brooks, A. F., Brown, B. C., Brown, D. D., Brozzetti, M. L., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bucci, F., Buchanan, J., Bulashenko, O., Bulik, T., Bulten, H. J., Buonanno, A., Burtnyk, K., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. Cabourn, Cabras, G., Cabrita, R., Cáceres-Barbosa, V., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Santoro, G. Caneva, Cannon, K. C., Cao, H., Capistran, L. A., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlassara, M., Carlin, J. B., Carpinelli, M., Carrillo, G., Carter, J. J., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castro-Lucas, S. Y., Caudill, S., Cavaglià, M., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakraborty, P., Subrahmanya, S. Chalathadka, Chan, J. C. L., Chan, M., Chandra, K., Chang, R. -J., Chao, S., Charlton, E. L., Charlton, P., Chassande-Mottin, E., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chen, A., Chen, A. H. -Y., Chen, D., Chen, H., Chen, H. Y., Chen, J., Chen, K. H., Chen, Y., Chen, Yanbei, Chen, Yitian, Cheng, H. P., Chessa, P., Cheung, H. T., Cheung, S. Y., Chiadini, F., Chiarini, G., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Chou, C., Choudhary, S., Christensen, N., Chua, S. S. Y., Chugh, P., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciolfi, R., Clara, F., Clark, J. A., Clarke, J., Clarke, T. A., Clearwater, P., Clesse, S., Coccia, E., Codazzo, E., Cohadon, P. -F., Colace, S., Colleoni, M., Collette, C. G., Collins, J., Colloms, S., Colombo, A., Colpi, M., Compton, C. M., Connolly, G., Conti, L., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Cornish, N. J., Corsi, A., Cortese, S., Costa, C. A., Cottingham, R., Coughlin, M. W., Couineaux, A., Coulon, J. -P., Countryman, S. T., Coupechoux, J. -F., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, R., Craig, K., Creed, R., Creighton, J. D. E., Creighton, T. D., Cremonese, P., Criswell, A. W., Crockett-Gray, J. C. G., Crook, S., Crouch, R., Csizmazia, J., Cudell, J. R., Cullen, T. J., Cumming, A., Cuoco, E., Cusinato, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Pra, S. Dal, Dálya, G., D'Angelo, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darroch, K. E., Dartez, L. P., Dasgupta, A., Datta, S., Dattilo, V., Daumas, A., Davari, N., Dave, I., Davenport, A., Davier, M., Davies, T. F., Davis, D., Davis, L., Davis, M. C., Davis, P. J., Dax, M., De Bolle, J., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., De Lillo, F., Dell'Aquila, D., Del Pozzo, W., De Marco, F., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., DePergola, N., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhani, A., Diab, R., Díaz, M. C., Di Cesare, M., Dideron, G., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giovanni, M., Di Girolamo, T., Diksha, D., Di Michele, A., Ding, J., Di Pace, S., Di Palma, I., Di Renzo, F., Divyajyoti, Dmitriev, A., Doctor, Z., Dohmen, E., Doleva, P. P., Dominguez, D., D'Onofrio, L., Donovan, F., Dooley, K. L., Dooney, T., Doravari, S., Dorosh, O., Drago, M., Driggers, J. C., Ducoin, J. -G., Dunn, L., Dupletsa, U., D'Urso, D., Duval, H., Duverne, P. -A., Dwyer, S. E., Eassa, C., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eichholz, J., Einsle, H., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Eleveld, R. M., Emma, M., Endo, K., Engl, A. J., Enloe, E., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etzel, T., Evans, M., Evstafyeva, T., Ewing, B. E., Ezquiaga, J. M., Fabrizi, F., Faedi, F., Fafone, V., Fairhurst, S., Farah, A. M., Farr, B., Farr, W. M., Favaro, G., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Felicetti, R., Fenyvesi, E., Ferguson, D. L., Ferraiuolo, S., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, A., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Fleischer, S. M., Fleming, L. S., Floden, E., Foley, E. M., Fong, H., Font, J. A., Fornal, B., Forsyth, P. W. F., Franceschetti, K., Franchini, N., Frasca, S., Frasconi, F., Mascioli, A. Frattale, Frei, Z., Freise, A., Freitas, O., Frey, R., Frischhertz, W., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fuentes-Garcia, M., Fujii, S., Fujimori, T., Fulda, P., Fyffe, M., Gadre, B., Gair, J. R., Galaudage, S., Galdi, V., Gallagher, H., Gallardo, S., Gallego, B., Gamba, R., Gamboa, A., Ganapathy, D., Ganguly, A., Garaventa, B., García-Bellido, J., Núñez, C. García, García-Quirós, C., Gardner, J. W., Gardner, K. A., Gargiulo, J., Garron, A., Garufi, F., Gasbarra, C., Gateley, B., Gayathri, V., Gemme, G., Gennai, A., Gennari, V., George, J., George, R., Gerberding, O., Gergely, L., Ghosh, Archisman, Ghosh, Sayantan, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Suprovo, Ghosh, Tathagata, Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gibson, D. T., Gier, C., Giri, P., Gissi, F., Gkaitatzis, S., Glanzer, J., Glotin, F., Godfrey, J., Godwin, P., Goebbels, N. L., Goetz, E., Golomb, J., Lopez, S. Gomez, Goncharov, B., Gong, Y., González, G., Goodarzi, P., Goode, S., Goodwin-Jones, A. W., Gosselin, M., Göttel, A. S., Gouaty, R., Gould, D. W., Govorkova, K., Goyal, S., Grace, B., Grado, A., Graham, V., Granados, A. E., Granata, M., Granata, V., Gras, S., Grassia, P., Gray, A., Gray, C., Gray, R., Greco, G., Green, A. C., Green, S. M., Green, S. R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W. L., Griggs, H. L., Grignani, G., Grimaldi, A., Grimaud, C., Grote, H., Guerra, D., Guetta, D., Guidi, G. M., Guimaraes, A. R., Gulati, H. K., Gulminelli, F., Gunny, A. M., Guo, H., Guo, W., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, Ish, Gupta, N. C., Gupta, P., Gupta, S. K., Gupta, T., Gupte, N., Gurs, J., Gutierrez, N., Guzman, F., H, H. -Y., Haba, D., Haberland, M., Haino, S., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hanselman, A. G., Hansen, H., Hanson, J., Harada, R., Hardison, A. R., Haris, K., Harmark, T., Harms, J., Harry, G. M., Harry, I. W., Hart, J., Haskell, B., Haster, C. -J., Hathaway, J. S., Haughian, K., Hayakawa, H., Hayama, K., Hayes, R., Heffernan, A., Heidmann, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Henderson-Sapir, O., Hendry, M., Heng, I. S., Hennes, E., Henshaw, C., Hertog, T., Heurs, M., Hewitt, A. L., Heyns, J., Higginbotham, S., Hild, S., Hill, S., Himemoto, Y., Hirata, N., Hirose, C., Hoang, S., Hochheim, S., Hofman, D., Holland, N. A., Holley-Bockelmann, K., Holmes, Z. J., Holz, D. E., Honet, L., Hong, C., Hornung, J., Hoshino, S., Hough, J., Hourihane, S., Howell, E. J., Hoy, C. G., Hrishikesh, C. A., Hsieh, H. -F., Hsiung, C., Hsu, H. C., Hsu, W. -F., Hu, P., Hu, Q., Huang, H. Y., Huang, Y. -J., Huddart, A. D., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huxford, R., Huynh-Dinh, T., Iampieri, L., Iandolo, G. A., Ianni, M., Iess, A., Imafuku, H., Inayoshi, K., Inoue, Y., Iorio, G., Iqbal, M. H., Irwin, J., Ishikawa, R., Isi, M., Ismail, M. A., Itoh, Y., Iwanaga, H., Iwaya, M., Iyer, B. R., JaberianHamedan, V., Jacquet, C., Jacquet, P. -E., Jadhav, S. J., Jadhav, S. P., Jain, T., James, A. L., James, P. A., Jamshidi, R., Janquart, J., Janssens, K., Janthalur, N. N., Jaraba, S., Jaranowski, P., Jaume, R., Javed, W., Jennings, A., Jia, W., Jiang, J., Kubisz, J., Johanson, C., Johns, G. R., Johnson, N. A., Johnston, M. C., Johnston, R., Johny, N., Jones, D. H., Jones, D. I., Jones, R., Jose, S., Joshi, P., Ju, L., Jung, K., Junker, J., Juste, V., Kajita, T., Kaku, I., Kalaghatgi, C., Kalogera, V., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Kashyap, R., Kasprzack, M., Kastaun, W., Kato, T., Katsavounidis, E., Katzman, W., Kaushik, R., Kawabe, K., Kawamoto, R., Kazemi, A., Keitel, D., Kelley-Derzon, J., Kennington, J., Kesharwani, R., Key, J. S., Khadela, R., Khadka, S., Khalili, F. Y., Khan, F., Khan, I., Khanam, T., Khursheed, M., Khusid, N. M., Kiendrebeogo, W., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, K., Kim, M. H., Kim, S., Kim, Y. -M., Kimball, C., Kinley-Hanlon, M., Kinnear, M., Kissel, J. S., Klimenko, S., Knee, A. M., Knust, N., Kobayashi, K., Obergaulinger, M., Koch, P., Koehlenbeck, S. M., Koekoek, G., Kohri, K., Kokeyama, K., Koley, S., Kolitsidou, P., Kolstein, M., Komori, K., Kong, A. K. H., Kontos, A., Korobko, M., Kossak, R. V., Kou, X., Koushik, A., Kouvatsos, N., Kovalam, M., Kozak, D. B., Kranzhoff, S. L., Kringel, V., Krishnendu, N. V., Królak, A., Kruska, K., Kuehn, G., Kuijer, P., Kulkarni, S., Ramamohan, A. Kulur, Kumar, A., Kumar, Praveen, Kumar, Prayush, Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuntimaddi, N., Kuroyanagi, S., Kurth, N. J., Kuwahara, S., Kwak, K., Kwan, K., Kwok, J., Lacaille, G., Lagabbe, P., Laghi, D., Lai, S., Laity, A. H., Lakkis, M. H., Lalande, E., Lalleman, M., Lalremruati, P. C., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rana, A., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Lawrence, J., Lawrence, M. N., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Lecoeuche, Y. K., Lee, H. M., Lee, H. W., Lee, K., Lee, R. -K., Lee, R., Lee, S., Lee, Y., Legred, I. N., Lehmann, J., Lehner, L., Jean, M. Le, Lemaître, A., Lenti, M., Leonardi, M., Lequime, M., Leroy, N., Lesovsky, M., Letendre, N., Lethuillier, M., Levin, S. E., Levin, Y., Leyde, K., Li, A. K. Y., Li, K. L., Li, T. G. F., Li, X., Li, Z., Lihos, A., Lin, C-Y., Lin, C. -Y., Lin, E. T., Lin, F., Lin, H., Lin, L. C. -C., Lin, Y. -C., Linde, F., Linker, S. D., Littenberg, T. B., Liu, A., Liu, G. C., Liu, Jian, Villarreal, F. Llamas, Llobera-Querol, J., Lo, R. K. L., Locquet, J. -P., London, L. T., Longo, A., Lopez, D., Portilla, M. Lopez, Lorenzini, M., Lorenzo-Medina, A., Loriette, V., Lormand, M., Losurdo, G., Lott IV, T. P., Lough, J. D., Loughlin, H. A., Lousto, C. O., Lowry, M. J., Lu, N., Lück, H., Lumaca, D., Lundgren, A. P., Lussier, A. W., Ma, L. -T., Ma, S., Ma'arif, M., Macas, R., Macedo, A., MacInnis, M., Maciy, R. R., Macleod, D. M., MacMillan, I. A. O., Macquet, A., Macri, D., Maeda, K., Maenaut, S., Hernandez, I. Magaña, Magare, S. S., Magazzù, C., Magee, R. M., Maggio, E., Maggiore, R., Magnozzi, M., Mahesh, M., Mahesh, S., Maini, M., Majhi, S., Majorana, E., Makarem, C. N., Makelele, E., Malaquias-Reis, J. A., Mali, U., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mannix, B., Mansell, G. L., Mansingh, G., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Pina, D. Marín, Marion, F., Márka, S., Márka, Z., Markosyan, A. S., Markowitz, A., Maros, E., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, B. B., Martinez, M., Martinez, V., Martini, A., Martinovic, K., Martins, J. C., Martynov, D. V., Marx, E. J., Massaro, L., Masserot, A., Masso-Reid, M., Mastrodicasa, M., Mastrogiovanni, S., Matcovich, T., Matiushechkina, M., Matsuyama, M., Mavalvala, N., Maxwell, N., McCarrol, G., McCarthy, R., McClelland, D. E., McCormick, S., McCuller, L., McEachin, S., McElhenny, C., McGhee, G. I., McGinn, J., McGowan, K. B. M., McIver, J., McLeod, A., McRae, T., Meacher, D., Meijer, Q., Melatos, A., Mellaerts, S., Menendez-Vazquez, A., Menoni, C. S., Mera, F., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Mérou, J. R., Merritt, J. D., Merzougui, M., Messenger, C., Messick, C., Meyer-Conde, M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Miller, A. 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- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the results of a search for gravitational-wave transients associated with core-collapse supernova SN 2023ixf, which was observed in the galaxy Messier 101 via optical emission on 2023 May 19th, during the LIGO-Virgo-KAGRA 15th Engineering Run. We define a five-day on-source window during which an accompanying gravitational-wave signal may have occurred. No gravitational waves have been identified in data when at least two gravitational-wave observatories were operating, which covered $\sim 14\%$ of this five-day window. We report the search detection efficiency for various possible gravitational-wave emission models. Considering the distance to M101 (6.7 Mpc), we derive constraints on the gravitational-wave emission mechanism of core-collapse supernovae across a broad frequency spectrum, ranging from 50 Hz to 2 kHz where we assume the GW emission occurred when coincident data are available in the on-source window. Considering an ellipsoid model for a rotating proto-neutron star, our search is sensitive to gravitational-wave energy $1 \times 10^{-5} M_{\odot} c^2$ and luminosity $4 \times 10^{-5} M_{\odot} c^2/\text{s}$ for a source emitting at 50 Hz. These constraints are around an order of magnitude more stringent than those obtained so far with gravitational-wave data. The constraint on the ellipticity of the proto-neutron star that is formed is as low as $1.04$, at frequencies above $1200$ Hz, surpassing results from SN 2019ejj., Comment: Main paper: 6 pages, 4 figures and 1 table. Total with appendices: 20 pages, 4 figures, and 1 table
- Published
- 2024
9. A search using GEO600 for gravitational waves coincident with fast radio bursts from SGR 1935+2154
- Author
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The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abac, A. G., Abbott, R., Abouelfettouh, I., Acernese, F., Ackley, K., Adhicary, S., Adhikari, N., Adhikari, R. X., Adkins, V. K., Agarwal, D., Agathos, M., Abchouyeh, M. Aghaei, Aguiar, O. D., Aguilar, I., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Albanesi, S., Alfaidi, R. A., Al-Jodah, A., Alléné, C., Allocca, A., Al-Shammari, S., Altin, P. A., Alvarez-Lopez, S., Amato, A., Amez-Droz, L., Amorosi, A., Amra, C., Ananyeva, A., Anderson, S. B., Anderson, W. G., Andia, M., Ando, M., Andrade, T., Andres, N., Andrés-Carcasona, M., Andrić, T., Anglin, J., Ansoldi, S., Antelis, J. M., Antier, S., Aoumi, M., Appavuravther, E. Z., Appert, S., Apple, S. K., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Argianas, L., Aritomi, N., Armato, F., Arnaud, N., Arogeti, M., Aronson, S. M., Ashton, G., Aso, Y., Assiduo, M., Melo, S. Assis de Souza, Aston, S. M., Astone, P., Attadio, F., Aubin, F., AultONeal, K., Avallone, G., Azrad, D., Babak, S., Badaracco, F., Badger, C., Bae, S., Bagnasco, S., Bagui, E., Baier, J. G., Baiotti, L., Bajpai, R., Baka, T., Ball, M., Ballardin, G., Ballmer, S. W., Banagiri, S., Banerjee, B., Bankar, D., Baral, P., Barayoga, J. C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartoletti, A. M., Barton, M. A., Bartos, I., Basak, S., Basalaev, A., Bassiri, R., Basti, A., Bates, D. E., Bawaj, M., Baxi, P., Bayley, J. C., Baylor, A. C., Baynard II, P. A., Bazzan, M., Bedakihale, V. M., Beirnaert, F., Bejger, M., Belardinelli, D., Bell, A. S., Benedetto, V., Benoit, W., Bentley, J. D., Yaala, M. Ben, Bera, S., Berbel, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Beroiz, M., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bevins, N., Bhandare, R., Bhardwaj, U., Bhatt, R., Bhattacharjee, D., Bhaumik, S., Bhowmick, S., Bianchi, A., Bilenko, I. A., Billingsley, G., Binetti, A., Bini, S., Birnholtz, O., Biscoveanu, S., Bisht, A., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blagg, L. A., Blair, C. D., Blair, D. G., Bobba, F., Bode, N., Boileau, G., Boldrini, M., Bolingbroke, G. N., Bolliand, A., Bonavena, L. D., Bondarescu, R., Bondu, F., Bonilla, E., Bonilla, M. S., Bonino, A., Bonnand, R., Booker, P., Borchers, A., Boschi, V., Bose, S., Bossilkov, V., Boudart, V., Boudon, A., Bozzi, A., Bradaschia, C., Brady, P. R., Braglia, M., Branch, A., Branchesi, M., Brandt, J., Braun, I., Breschi, M., Briant, T., Brillet, A., Brinkmann, M., Brockill, P., Brockmueller, E., Brooks, A. F., Brown, B. C., Brown, D. D., Brozzetti, M. L., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bucci, F., Buchanan, J., Bulashenko, O., Bulik, T., Bulten, H. J., Buonanno, A., Burtnyk, K., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. 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K., Rinaldi, S., Rittmeyer, J., Robertson, C., Robinet, F., Robinson, M., Rocchi, A., Rolland, L., Rollins, J. G., Romano, A. E., Romano, R., Romero, A., Romero-Shaw, I. M., Romie, J. H., Ronchini, S., Roocke, T. J., Rosa, L., Rosauer, T. J., Rose, C. A., Rosińska, D., Ross, M. P., Rossello, M., Rowan, S., Roy, S. K., Roy, S., Rozza, D., Ruggi, P., Ruhama, N., Morales, E. Ruiz, Ruiz-Rocha, K., Sachdev, S., Sadecki, T., Sadiq, J., Saffarieh, P., Sah, M. R., Saha, S. S., Saha, S., Sainrat, T., Menon, S. Sajith, Sakai, K., Sakellariadou, M., Sakon, S., Salafia, O. S., Salces-Carcoba, F., Salconi, L., Saleem, M., Salemi, F., Sallé, M., Salvador, S., Sanchez, A., Sanchez, E. J., Sanchez, J. H., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Sänger, E. M., Santoliquido, F., Saravanan, T. R., Sarin, N., Sasaoka, S., Sasli, A., Sassi, P., Sassolas, B., Satari, H., Sato, R., Sato, Y., Sauter, O., Savage, R. L., Sawada, T., Sawant, H. L., Sayah, S., Scacco, V., Schaetzl, D., Scheel, M., Schiebelbein, A., Schiworski, M. G., Schmidt, P., Schmidt, S., Schnabel, R., Schneewind, M., Schofield, R. M. S., Schouteden, K., Schulte, B. W., Schutz, B. F., Schwartz, E., Scialpi, M., Scott, J., Scott, S. M., Seetharamu, T. C., Seglar-Arroyo, M., Sekiguchi, Y., Sellers, D., Sengupta, A. S., Sentenac, D., Seo, E. G., Seo, J. W., Sequino, V., Serra, M., Servignat, G., Sevrin, A., Shaffer, T., Shah, U. S., Shaikh, M. A., Shao, L., Sharma, A. K., Sharma, P., Sharma-Chaudhary, S., Shaw, M. R., Shawhan, P., Shcheblanov, N. S., Sheridan, E., Shikano, Y., Shikauchi, M., Shimode, K., Shinkai, H., Shiota, J., Shoemaker, D. H., Shoemaker, D. M., Short, R. W., ShyamSundar, S., Sider, A., Siegel, H., Sieniawska, M., Sigg, D., Silenzi, L., Simmonds, M., Singer, L. P., Singh, A., Singh, D., Singh, M. K., Singh, S., Singha, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, L., Smith, R. J. E., Smith, W. J., Soldateschi, J., Somiya, K., Song, I., Soni, K., Soni, S., Sordini, V., Sorrentino, F., Sorrentino, N., Sotani, H., Soulard, R., Southgate, A., Spagnuolo, V., Spencer, A. P., Spera, M., Spinicelli, P., Spoon, J. B., Sprague, C. A., Srivastava, A. K., Stachurski, F., Steer, D. A., Steinlechner, J., Steinlechner, S., Stergioulas, N., Stevens, P., StPierre, M., Stratta, G., Strong, M. D., Strunk, A., Sturani, R., Stuver, A. L., Suchenek, M., Sudhagar, S., Sueltmann, N., Suleiman, L., Sullivan, K. D., Sun, L., Sunil, S., Suresh, J., Sutton, P. J., Suzuki, T., Suzuki, Y., Swinkels, B. L., Syx, A., Szczepańczyk, M. J., Szewczyk, P., Tacca, M., Tagoshi, H., Tait, S. C., Takahashi, H., Takahashi, R., Takamori, A., Takase, T., Takatani, K., Takeda, H., Takeshita, K., Talbot, C., Tamaki, M., Tamanini, N., Tanabe, D., Tanaka, K., Tanaka, S. J., Tanaka, T., Tang, D., Tanioka, S., Tanner, D. B., Tao, L., Tapia, R. D., Martín, E. N. Tapia San, Tarafder, R., Taranto, C., Taruya, A., Tasson, J. D., Teloi, M., Tenorio, R., Themann, H., Theodoropoulos, A., Thirugnanasambandam, M. P., Thomas, L. M., Thomas, M., Thomas, P., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tissino, J., Tiwari, A., Tiwari, P., Tiwari, S., Tiwari, V., Todd, M. R., Toivonen, A. M., Toland, K., Tolley, A. E., Tomaru, T., Tomita, K., Tomura, T., Tong-Yu, C., Toriyama, A., Toropov, N., Torres-Forné, A., Torrie, C. I., Toscani, M., Melo, I. Tosta e, Tournefier, E., Trapananti, A., Travasso, F., Traylor, G., Trevor, M., Tringali, M. C., Tripathee, A., Troian, G., Troiano, L., Trovato, A., Trozzo, L., Trudeau, R. J., Tsang, T. T. L., Tso, R., Tsuchida, S., Tsukada, L., Tsutsui, T., Turbang, K., Turconi, M., Turski, C., Ubach, H., Uchiyama, T., Udall, R. P., Uehara, T., Uematsu, M., Ueno, K., Ueno, S., Undheim, V., Ushiba, T., Vacatello, M., Vahlbruch, H., Vaidya, N., Vajente, G., Vajpeyi, A., Valdes, G., Valencia, J., Valentini, M., Vallejo-Peña, S. A., Vallero, S., Valsan, V., van Bakel, N., van Beuzekom, M., van Dael, M., Brand, J. F. J. van den, Broeck, C. Van Den, Vander-Hyde, D. C., van der Sluys, M., Van de Walle, A., van Dongen, J., Vandra, K., van Haevermaet, H., van Heijningen, J. V., Van Hove, P., VanKeuren, M., Vanosky, J., van Putten, M. H. P. M., van Ranst, Z., van Remortel, N., Vardaro, M., Vargas, A. F., Varghese, J. J., Varma, V., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venikoudis, S., Venneberg, J., Verdier, P., Verkindt, D., Verma, B., Verma, P., Verma, Y., Vermeulen, S. M., Vetrano, F., Veutro, A., Vibhute, A. M., Viceré, A., Vidyant, S., Viets, A. D., Vijaykumar, A., Vilkha, A., Villa-Ortega, V., Vincent, E. T., Vinet, J. -Y., Viret, S., Virtuoso, A., Vitale, S., Vives, A., Vocca, H., Voigt, D., von Reis, E. R. G., von Wrangel, J. S. A., Vyatchanin, S. P., Wade, L. E., Wade, M., Wagner, K. J., Wajid, A., Walker, M., Wallace, G. S., Wallace, L., Wang, H., Wang, J. Z., Wang, W. H., Wang, Z., Waratkar, G., Warner, J., Was, M., Washimi, T., Washington, N. Y., Watarai, D., Wayt, K. E., Weaver, B. R., Weaver, B., Weaving, C. R., Webster, S. A., Weinert, M., Weinstein, A. J., Weiss, R., Wellmann, F., Wen, L., Weßels, P., Wette, K., Whelan, J. T., Whiting, B. F., Whittle, C., Wildberger, J. B., Wilk, O. S., Wilken, D., Wilkin, A. T., Willadsen, D. J., Willetts, K., Williams, D., Williams, M. J., Williams, N. S., Willis, J. L., Willke, B., Wils, M., Winterflood, J., Wipf, C. C., Woan, G., Woehler, J., Wofford, J. K., Wolfe, N. E., Wong, H. T., Wong, H. W. Y., Wong, I. C. F., Wright, J. L., Wright, M., Wu, C., Wu, D. S., Wu, H., Wuchner, E., Wysocki, D. M., Xu, V. A., Xu, Y., Yadav, N., Yamamoto, H., Yamamoto, K., Yamamoto, T. S., Yamamoto, T., Yamamura, S., Yamazaki, R., Yan, S., Yan, T., Yang, F. W., Yang, F., Yang, K. Z., Yang, Y., Yarbrough, Z., Yasui, H., Yeh, S. -W., Yelikar, A. B., Yin, X., Yokoyama, J., Yokozawa, T., Yoo, J., Yu, H., Yuan, S., Yuzurihara, H., Zadrożny, A., Zanolin, M., Zeeshan, M., Zelenova, T., Zendri, J. -P., Zeoli, M., Zerrad, M., Zevin, M., Zhang, A. C., Zhang, L., Zhang, R., Zhang, T., Zhang, Y., Zhao, C., Zhao, Yue, Zhao, Yuhang, Zheng, Y., Zhong, H., Zhou, R., Zhu, X. -J., Zhu, Z. -H., Zucker, M. E., and Zweizig, J.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The magnetar SGR 1935+2154 is the only known Galactic source of fast radio bursts (FRBs). FRBs from SGR 1935+2154 were first detected by CHIME/FRB and STARE2 in 2020 April, after the conclusion of the LIGO, Virgo, and KAGRA Collaborations' O3 observing run. Here we analyze four periods of gravitational wave (GW) data from the GEO600 detector coincident with four periods of FRB activity detected by CHIME/FRB, as well as X-ray glitches and X-ray bursts detected by NICER and NuSTAR close to the time of one of the FRBs. We do not detect any significant GW emission from any of the events. Instead, using a short-duration GW search (for bursts $\leq$ 1 s) we derive 50\% (90\%) upper limits of $10^{48}$ ($10^{49}$) erg for GWs at 300 Hz and $10^{49}$ ($10^{50}$) erg at 2 kHz, and constrain the GW-to-radio energy ratio to $\leq 10^{14} - 10^{16}$. We also derive upper limits from a long-duration search for bursts with durations between 1 and 10 s. These represent the strictest upper limits on concurrent GW emission from FRBs., Comment: 15 pages of text including references, 4 figures, 5 tables
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- 2024
10. Adapting and Testing the Care Partner Hospital Assessment Tool for Use in Dementia Care: Protocol for a 2 Sequential Phase Study
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Beth Fields, Nicole Werner, Manish N Shah, Scott Hetzel, Blair P Golden, Andrea Gilmore-Bykovskyi, and Dorothy Farrar Edwards
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Medicine ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
BackgroundResearch and policy demonstrate the value of and need for systematically identifying and preparing care partners for their caregiving responsibilities while their family member or friend living with dementia is hospitalized. The Care Partner Hospital Assessment Tool (CHAT) has undergone content and face validation and has been endorsed as appropriate by clinicians to facilitate the timely identification and preparation of care partners of older adult patients during their hospitalization. However, the CHAT has not yet been adapted or prospectively evaluated for use with care partners of hospitalized people living with dementia. Adapting and testing the CHAT via a pilot study will provide the necessary evidence to optimize feasibility and enable future efficacy trials. ObjectiveThe purpose of this paper is to describe the study protocol for the adaptation and testing of the CHAT for use among care partners of hospitalized people living with dementia to better prepare them for their caregiving responsibilities after hospital discharge. MethodsOur protocol is based on the National Institutes of Health Stage Model and consists of 2 sequential phases, including formative research and the main trial. In phase 1, we will use a participatory human-centered design process that incorporates people living with dementia and their care partners, health care administrators, and clinicians to adapt the CHAT for dementia care (ie, the Dementia CHAT [D-CHAT]; stage IA). In phase 2, we will partner with a large academic medical system to complete a pilot randomized controlled trial to examine the feasibility and estimate the size of the effect of the D-CHAT on care partners’ preparedness for caregiving (stage IB). We anticipate this study to take approximately 60 months to complete, from study start-up procedures to dissemination. The 2 phases will take place between December 1, 2022, and November 30, 2027. ResultsThe study protocol will yield (1) a converged-upon, ready-for-feasibility testing D-CHAT; (2) descriptive and feasibility characteristics of delivering the D-CHAT; and (3) effect size estimates of the D-CHAT on care partner preparedness. We anticipate that the resultant D-CHAT will provide clinicians with guidance on how to identify and better prepare care partners for hospitalized people living with dementia. In turn, care partners will feel equipped to fulfill caregiving roles for their family members or friends living with dementia. ConclusionsThe expected results of this study are to favorably impact hospital-based care processes and outcomes for people living with dementia and their care partners and to elucidate the essential caregiving role that so many care partners of people living with dementia assume. Trial RegistrationClinicalTrials.gov NCT05592366; https://clinicaltrials.gov/ct2/show/NCT05592366 International Registered Report Identifier (IRRID)PRR1-10.2196/46808
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- 2023
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11. How Student, Family, and Community Engagement Impacts Students' Social, Emotional, and Academic Development (SEAD)
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Education Trust, Blair Wriston, and Nancy Duchesneau
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Student, family, and community engagement is an important ingredient to foster students' social, emotional, and academic development (SEAD). In this brief, the importance and impact of meaningful engagement--building personal relationships, trust, and mutual respect between students and their educators, families, and communities--is described, and common barriers are outlined. The authors offer recommendations on how to support meaningful engagement at federal, state, and local levels so that students' SEAD can thrive.
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- 2024
12. Inappropriate sinus tachycardia: a review
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Muzaffar Ali, Abdul Qadir Haji, Asim Kichloo, Blair P Grubb, and Khalil Kanjwal
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autonomic dysfunction ,inappropriate sinus tachycardia ,ivabradine ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Inappropriate sinus tachycardia (IST) has been defined as a resting heart rate of >100 beats per minute and an average 24-hour heart rate >90 bpm with distressing symptoms resulting from the persistent tachycardia. IST is prevalent in 1% of the middle-aged population, mostly females. Rarely can elderly patients also present with IST. Possible mechanisms of IST include intrinsic sinus node abnormality, beta-adrenergic receptor stimulating autoantibody, beta-adrenergic receptor supersensitivity, muscarinic receptor autoantibody, or hyposensitivity, impaired baroreflex control, depressed efferent parasympathetic/vagal function, nociceptive stimulation, central autonomic overactivity, aberrant neurohumoral modulation, etc. Symptoms associated with IST are palpitations, chest pain, fatigue, shortness of breath, presyncope, and syncope. Despite these distressing symptoms, IST has not been associated with tachycardia-associated cardiomyopathy or increased major cardiovascular events. Various treatment options for patients with IST are ivabradine, beta-adrenergic blockers, calcium channel blockers, psychiatric evaluation, and exercise training. Although, endocardial radiofrequency ablation targeting the sinus node has been used as a treatment modality for otherwise treatment-refractory IST, the results have been dismal. The other modalities used for refractory IST treatment are endocardial modification of the sinus node using radiofrequency energy, combined endo and epicardial ablation of the sinus node, thoracoscopic epicardial ablation of the sinus node, sinus node sparing thoracoscopic and endocardial hybrid ablation. The goal of this review is to provide the readership with the pathophysiological basis of IST and its management options.
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- 2021
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13. Robust soybean seed yield estimation using high-throughput ground robot videos
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Feng, Jiale, Blair, Samuel W., Ayanlade, Timilehin, Balu, Aditya, Ganapathysubramanian, Baskar, Singh, Arti, Sarkar, Soumik, and Singh, Asheesh K
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Computer Science - Computer Vision and Pattern Recognition - Abstract
We present a novel method for soybean (Glycine max (L.) Merr.) yield estimation leveraging high throughput seed counting via computer vision and deep learning techniques. Traditional methods for collecting yield data are labor-intensive, costly, prone to equipment failures at critical data collection times, and require transportation of equipment across field sites. Computer vision, the field of teaching computers to interpret visual data, allows us to extract detailed yield information directly from images. By treating it as a computer vision task, we report a more efficient alternative, employing a ground robot equipped with fisheye cameras to capture comprehensive videos of soybean plots from which images are extracted in a variety of development programs. These images are processed through the P2PNet-Yield model, a deep learning framework where we combined a Feature Extraction Module (the backbone of the P2PNet-Soy) and a Yield Regression Module to estimate seed yields of soybean plots. Our results are built on three years of yield testing plot data - 8500 in 2021, 2275 in 2022, and 650 in 2023. With these datasets, our approach incorporates several innovations to further improve the accuracy and generalizability of the seed counting and yield estimation architecture, such as the fisheye image correction and data augmentation with random sensor effects. The P2PNet-Yield model achieved a genotype ranking accuracy score of up to 83%. It demonstrates up to a 32% reduction in time to collect yield data as well as costs associated with traditional yield estimation, offering a scalable solution for breeding programs and agricultural productivity enhancement., Comment: 23 pages, 12 figures, 2 tables
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- 2024
14. Advanced LIGO detector performance in the fourth observing run
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Capote, E., Jia, W., Aritomi, N., Nakano, M., Xu, V., Abbott, R., Abouelfettouh, I., Adhikari, R. X., Ananyeva, A., Appert, S., Apple, S. K., Arai, K., Aston, S. M., Ball, M., Ballmer, S. W., Barker, D., Barsotti, L., Berger, B. K., Betzwieser, J., Bhattacharjee, D., Billingsley, G., Biscans, S., Blair, C. D., Bode, N., Bonilla, E., Bossilkov, V., Branch, A., Brooks, A. F., Brown, D. D., Bryant, J., Cahillane, C., Cao, H., Clara, F., Collins, J., Compton, C. M., Cottingham, R., Coyne, D. C., Crouch, R., Csizmazia, J., Cumming, A., Dartez, L. P., Davis, D., Demos, N., Dohmen, E., Driggers, J. C., Dwyer, S. E., Effler, A., Ejlli, A., Etzel, T., Evans, M., Feicht, J., Frey, R., Frischhertz, W., Fritschel, P., Frolov, V. V., Fuentes-Garcia, M., Fulda, P., Fyffe, M., Ganapathy, D., Gateley, B., Gayer, T., Giaime, J. A., Giardina, K. D., Glanzer, J., Goetz, E., Goetz, R., Goodwin-Jones, A. W., Gras, S., Gray, C., Griffith, D., Grote, H., Guidry, T., Gurs, J., Hall, E. D., Hanks, J., Hanson, J., Heintze, M. C., Helmling-Cornell, A. F., Holland, N. A., Hoyland, D., Huang, H. Y., Inoue, Y., James, A. L., Jamies, A., Jennings, A., Jones, D. H., Kabagoz, H. B., Karat, S., Karki, S., Kasprzack, M., Kawabe, K., Kijbunchoo, N., King, P. J., Kissel, J. S., Komori, K., Kontos, A., Kumar, Rahul, Kuns, K., Landry, M., Lantz, B., Laxen, M., Lee, K., Lesovsky, M., Villarreal, F. Llamas, Lormand, M., Loughlin, H. A., Macas, R., MacInnis, M., Makarem, C. N., Mannix, B., Mansell, G. L., Martin, R. M., Mason, K., Matichard, F., Mavalvala, N., Maxwell, N., McCarrol, G., McCarthy, R., McClelland, D. E., McCormick, S., McRae, T., Mera, F., Merilh, E. L., Meylahn, F., Mittleman, R., Moraru, D., Moreno, G., Mullavey, A., Nelson, T. J. N., Neunzert, A., Notte, J., Oberling, J., OHanlon, T., Osthelder, C., Ottaway, D. J., Overmier, H., Parker, W., Patane, O., Pele, A., Pham, H., Pirello, M., Pullin, J., Quetschke, V., Ramirez, K. E., Ransom, K., Reyes, J., Richardson, J. W., Robinson, M., Rollins, J. G., Romel, C. L., Romie, J. H., Ross, M. P., Ryan, K., Sadecki, T., Sanchez, A., Sanchez, E. J., Sanchez, L. E., Savage, R. L., Schaetzl, D., Schiworski, M. G., Schnabel, R., Schofield, R. M. S., Schwartz, E., Sellers, D., Shaffer, T., Short, R. W., Sigg, D., Slagmolen, B. J. J., Soike, C., Soni, S., Srivastava, V., Sun, L., Tanner, D. B., Thomas, M., Thomas, P., Thorne, K. A., Todd, M. R., Torrie, C. I., Traylor, G., Ubhi, A. S., Vajente, G., Vanosky, J., Vecchio, A., Veitch, P. J., Vibhute, A. M., von Reis, E. R. G., Warner, J., Weaver, B., Weiss, R., Whittle, C., Willke, B., Wipf, C. C., Wright, J. L., Yamamoto, H., Zhang, L., and Zucker, M. E.
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General Relativity and Quantum Cosmology ,Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors ,Physics - Optics ,Quantum Physics - Abstract
On May 24th, 2023, the Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO), joined by the Advanced Virgo and KAGRA detectors, began the fourth observing run for a two-year-long dedicated search for gravitational waves. The LIGO Hanford and Livingston detectors have achieved an unprecedented sensitivity to gravitational waves, with an angle-averaged median range to binary neutron star mergers of 152 Mpc and 160 Mpc, and duty cycles of 65.0% and 71.2%, respectively, with a coincident duty cycle of 52.6%. The maximum range achieved by the LIGO Hanford detector is 165 Mpc and the LIGO Livingston detector 177 Mpc, both achieved during the second part of the fourth observing run. For the fourth run, the quantum-limited sensitivity of the detectors was increased significantly due to the higher intracavity power from laser system upgrades and replacement of core optics, and from the addition of a 300 m filter cavity to provide the squeezed light with a frequency-dependent squeezing angle, part of the A+ upgrade program. Altogether, the A+ upgrades led to reduced detector-wide losses for the squeezed vacuum states of light which, alongside the filter cavity, enabled broadband quantum noise reduction of up to 5.2 dB at the Hanford observatory and 6.1 dB at the Livingston observatory. Improvements to sensors and actuators as well as significant controls commissioning increased low frequency sensitivity. This paper details these instrumental upgrades, analyzes the noise sources that limit detector sensitivity, and describes the commissioning challenges of the fourth observing run., Comment: 26 pages, 18 figures
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- 2024
15. Adding a suitable unknot to any link equates bridge number and meridional rank
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Blair, Ryan, Kjuchukova, Alexandra, and Pfaff, Ella
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Mathematics - Geometric Topology - Abstract
Given any link $L\subseteq S^3$, we show that it is possible to embed an unknot $U$ in its complement so that the link $L\cup U$ satisfies the Meridional Rank Conjecture (MRC). The bridge numbers in our construction fit into the equality $\beta(L\cup U)=2\beta(L)-1=\text{rank}(\pi_1(S^3\backslash (L\cup U)))$. In addition, we prove the MRC for new infinite families of links and distinguish them from previously settled cases through an application of bridge distance., Comment: 14 pages, 4 figures, 4 footnotes, 1 stanza
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- 2024
16. $L^p - L^q$ resolvent restriction estimates for submanifolds
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Blair, Matthew D. and Park, Chamsol
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Mathematics - Analysis of PDEs ,Mathematics - Classical Analysis and ODEs ,Mathematics - Spectral Theory ,35S30, 42B37, 58J40 - Abstract
We consider restriction analogues on hypersurfaces of the uniform Sobolev inequalities in Kenig, Ruiz, and Sogge and the resolvent estimates in Dos Santos Ferreira, Kenig, and Salo.
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- 2024
17. High-fidelity gates in a transmon using bath engineering for passive leakage reset
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Thorbeck, Ted, McDonald, Alexander, Lanes, O., Blair, John, Keefe, George, Stabile, Adam A., Royer, Baptiste, Govia, Luke C. G., and Blais, Alexandre
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Quantum Physics - Abstract
Leakage, the occupation of any state not used in the computation, is one of the of the most devastating errors in quantum error correction. Transmons, the most common superconducting qubits, are weakly anharmonic multilevel systems, and are thus prone to this type of error. Here we demonstrate a device which reduces the lifetimes of the leakage states in the transmon by three orders of magnitude, while protecting the qubit lifetime and the single-qubit gate fidelties. To do this we attach a qubit through an on-chip seventh-order Chebyshev filter to a cold resistor. The filter is engineered such that the leakage transitions are in its passband, while the qubit transition is in its stopband. Dissipation through the filter reduces the lifetime of the transmon's $f$ state, the lowest energy leakage state, by three orders of magnitude to 33 ns, while simultaneously keeping the qubit lifetime to greater than 100 $\mu$s. Even though the $f$ state is transiently populated during a single qubit gate, no negative effect of the filter is detected with errors per gate approaching 1e-4. Modelling the filter as coupled linear harmonic oscillators, our theoretical analysis of the device corroborate our experimental findings. This leakage reduction unit turns leakage errors into errors within the qubit subspace that are correctable with traditional quantum error correction. We demonstrate the operation of the filter as leakage reduction unit in a mock-up of a single-qubit quantum error correcting cycle, showing that the filter increases the seepage rate back to the qubit subspace., Comment: 14 pages, 9 figures
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- 2024
18. Birefringence in a Silicon Beamsplitter at 2um for Future Gravitational Wave Detectors
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Adam, Alex, Blair, Carl, and Zhao, Chunnong
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Physics - Optics - Abstract
The next generation of gravitational wave detectors will move to cryogenic operation in order to reduce thermal noise and thermal distortion. This necessitates a change in mirror substrate with silicon being a good candidate. Birefringence is an effect that will degrade the sensitivity of a detector and is of greater concern in silicon due to its crystalline nature. We measure the birefringence in a <100> float zone silicon beamsplitter since we expect there to be a large inherent birefringence due to the spatial dispersion effect. We observe that the birefringence varied between $3.44 \pm 0.12 \times 10^{-7}$ and $1.63 \pm 0.05 \times 10^{-7}$ and estimate the birefringence along the <110> axis to be $1.64 \pm 0.5 \times 10^{-6}$ at 2um. We demonstrate this effect and argue that it strengthens the case for 2um and <100> silicon., Comment: 10 pages, 10 figures
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- 2024
19. Democratizing Reward Design for Personal and Representative Value-Alignment
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Blair, Carter, Larson, Kate, and Law, Edith
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Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction - Abstract
Aligning AI agents with human values is challenging due to diverse and subjective notions of values. Standard alignment methods often aggregate crowd feedback, which can result in the suppression of unique or minority preferences. We introduce Interactive-Reflective Dialogue Alignment, a method that iteratively engages users in reflecting on and specifying their subjective value definitions. This system learns individual value definitions through language-model-based preference elicitation and constructs personalized reward models that can be used to align AI behaviour. We evaluated our system through two studies with 30 participants, one focusing on "respect" and the other on ethical decision-making in autonomous vehicles. Our findings demonstrate diverse definitions of value-aligned behaviour and show that our system can accurately capture each person's unique understanding. This approach enables personalized alignment and can inform more representative and interpretable collective alignment strategies., Comment: 19 pages, 16 figures
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- 2024
20. Dynamic Glucose Enhanced Imaging using Direct Water Saturation
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Knutsson, Linda, Yadav, Nirbhay N., Ali, Sajad Mohammed, Kamson, David Olayinka, Demetriou, Eleni, Seidemo, Anina, Blair, Lindsay, Lin, Doris D., Laterra, John, and van Zijl, Peter C. M.
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Physics - Medical Physics - Abstract
Purpose: Dynamic glucose enhanced (DGE) MRI studies employ chemical exchange saturation transfer (CEST) or spin lock (CESL) to study glucose uptake. Currently, these methods are hampered by low effect size and sensitivity to motion. To overcome this, we propose to utilize exchange-based linewidth (LW) broadening of the direct water saturation (DS) curve of the water saturation spectrum (Z-spectrum) during and after glucose infusion (DS-DGE MRI). Methods: To estimate the glucose-infusion-induced LW changes ($\Delta$LW), Bloch-McConnell simulations were performed for normoglycemia and hyperglycemia in blood, gray matter (GM), white matter (WM), CSF, and malignant tumor tissue. Whole-brain DS-DGE imaging was implemented at 3 tesla using dynamic Z-spectral acquisitions (1.2 s per offset frequency, 38 s per spectrum) and assessed on four brain tumor patients using infusion of 35 g of D-glucose. To assess $\Delta$LW, a deep learning-based Lorentzian fitting approach was employed on voxel-based DS spectra acquired before, during, and post-infusion. Area-under-the-curve (AUC) images, obtained from the dynamic $\Delta$LW time curves, were compared qualitatively to perfusion-weighted imaging (PWI). Results: In simulations, $\Delta$LW was 1.3%, 0.30%, 0.29/0.34%, 7.5%, and 13% in arterial blood, venous blood, GM/WM, malignant tumor tissue, and CSF, respectively. In vivo, $\Delta$LW was approximately 1% in GM/WM, 5-20% for different tumor types, and 40% in CSF. The resulting DS-DGE AUC maps clearly outlined lesion areas. Conclusions: DS-DGE MRI is highly promising for assessing D-glucose uptake. Initial results in brain tumor patients show high-quality AUC maps of glucose-induced line broadening and DGE-based lesion enhancement similar and/or complementary to PWI., Comment: 13 pages, 6 figures
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- 2024
21. A Search for 3-mm Molecular Absorption Line Transitions in the Magellanic Stream
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Steffes, Lucille, Rybarczyk, Daniel R., Stanimirović, Snežana, Dawson, J. R., Putman, Mary, Richter, Philipp, Gallagher III, John, Liszt, Harvey, Murray, Claire, Dickey, John, Heiles, Carl, Hernandez, Audra, Lindner, Robert, Liu, Yangyang, McClure-Griffiths, Naomi, Wong, Tony, and Savage, Blair
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Astrophysics - Astrophysics of Galaxies - Abstract
The Magellanic Stream, a tidal tail of diffuse gas falling onto the Milky Way, formed by interactions between the Small and Large Magellanic Clouds, is primarily composed of neutral atomic hydrogen (HI). The deficiency of dust and the diffuse nature of the present gas make molecular formation rare and difficult, but if present, could lead to regions potentially suitable for star formation, thereby allowing us to probe conditions of star formation similar to those at high redshifts. We search for HCO$^+$, HCN, HNC, and C$_2$H using the highest sensitivity observations of molecular absorption data from the Atacama Large Millimeter Array to trace these regions, comparing with HI archival data to compare these environments in the Magellanic Stream to the HI column density threshold for molecular formation in the Milky Way. We also compare the line of sight locations with confirmed locations of stars, molecular hydrogen, and OI detections, though at higher sensitivities than the observations presented here. We find no detections to a 3$\sigma$ significance, despite four sightlines having column densities surpassing the threshold for molecular formation in the diffuse regions of the Milky Way. Here we present our calculations for the upper limits of the column densities of each of these molecular absorption lines, ranging from $3 \times 10^{10}$ to $1 \times 10^{13}$ cm$^{-2}$. The non-detection of HCO$^+$ suggests that at least one of the following is true: (i) $X_{HCO^+, \mathrm{MS}}$ is significantly lower than the Milky Way value; (ii) that the widespread diffuse molecular gas observed in the Milky Way's diffuse ISM does not have a direct analog in the MS; (iii) the HI-to-H$_2$ transition occurs in the MS at a higher surface density in the MS than in the LMC or SMC; or (iv) molecular gas exists in the MS, but only in small, dense clumps., Comment: 19 pages, 7 figures, 4 tables, Accepted for publication in PASA
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- 2024
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22. Efficient Simulation of Open Quantum Systems on NISQ Trapped-Ion Hardware
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Burdine, Colin, Bauer, Nora, Siopsis, George, and Blair, Enrique P.
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Quantum Physics - Abstract
Simulating open quantum systems, which interact with external environments, presents significant challenges on noisy intermediate-scale quantum (NISQ) devices due to limited qubit resources and noise. In this paper, we propose an efficient framework for simulating open quantum systems on NISQ hardware by leveraging a time-perturbative Kraus operator representation of the system's dynamics. Our approach avoids the computationally expensive Trotterization method and exploits the Lindblad master equation to represent time evolution in a compact form, particularly for systems satisfying specific commutation relations. We demonstrate the efficiency of our method by simulating quantum channels, such as the continuous-time Pauli channel and damped harmonic oscillators, on NISQ trapped-ion hardware, including IonQ Harmony and Quantinuum H1-1. Additionally, we introduce hardware-agnostic error mitigation techniques, including Pauli channel fitting and quantum depolarizing channel inversion, to enhance the fidelity of quantum simulations. Our results show strong agreement between the simulations on real quantum hardware and exact solutions, highlighting the potential of Kraus-based methods for scalable and accurate simulation of open quantum systems on NISQ devices. This framework opens pathways for simulating more complex systems under realistic conditions in the near term., Comment: 18 pages, 12 figures
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- 2024
23. A JWST/MIRI View of the ISM in M83: I. Resolved Molecular Hydrogen Properties, Star Formation, and Feedback
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Jones, Logan H., Hernandez, Svea, Smith, Linda J., Togi, Aditya, Diaz-Santos, Tanio, Aloisi, Alessandra, Blair, William, Hirschauer, Alec S., Hunt, Leslie K., James, Bethan L., Kumari, Nimisha, Lebouteiller, Vianney, Mingozzi, Matilde, and Ramambason, Lise
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Astrophysics - Astrophysics of Galaxies - Abstract
We present a spatially-resolved (~3 pc pix$^{-1}$) analysis of the distribution, kinematics, and excitation of warm H2 gas in the nuclear starburst region of M83. Our JWST/MIRI IFU spectroscopy reveals a clumpy reservoir of warm H2 (> 200 K) with a mass of ~2.3 x 10$^{5}$ Msun in the area covered by all four MRS channels. We additionally use the [Ne II] 12.8 ${\mu}$m and [Ne III] 15.5 ${\mu}$m lines as tracers of the star formation rate, ionizing radiation hardness, and kinematics of the ionized ISM, finding tantalizing connections to the H2 properties and to the ages of the underlying stellar populations. Finally, qualitative comparisons to the trove of public, high-spatial-resolution multiwavelength data available on M83 shows that our MRS spectroscopy potentially traces all stages of the process of creating massive star clusters, from the embedded proto-cluster phase through the dispersion of ISM from stellar feedback., Comment: 21 pages, 11+1 figures; submitted to ApJ
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- 2024
24. The Green Monster hiding in front of Cas A: JWST reveals a dense and dusty circumstellar structure pockmarked by ejecta interactions
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De Looze, Ilse, Milisavljevic, Dan, Temim, Tea, Dickinson, Danielle, Fesen, Robert, Arendt, Richard G., Chastenet, Jeremy, Orlando, Salvatore, Vink, Jacco, Barlow, Michael J., Kirchschlager, Florian, Priestley, Felix D., Raymond, John C., Rho, Jeonghee, Sartorio, Nina S., Scheffler, Tassilo, Schmidt, Franziska, Blair, William P., Fox, Ori, Fryer, Christopher, Janka, Hans-Thomas, Koo, Bon-Chul, Laming, J. Martin, Matsuura, Mikako, Patnaude, Dan, Relano, Monica, Rest, Armin, Schmidt, Judy, Smith, Nathan, and Sravan, Niharika
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
JWST observations of the young Galactic supernova remnant Cassiopeia A revealed an unexpected structure seen as a green emission feature in colored composite MIRI F1130W and F1280W images - hence dubbed the Green Monster - that stretches across the central parts of the remnant in projection. Combining the kinematic information from NIRSpec and MIRI MRS with the multi-wavelength imaging from NIRCam and MIRI, we associate the Green Monster with circumstellar material that was lost during an asymmetric mass-loss phase. MIRI images are dominated by dust emission but its spectra show emission lines from Ne, H and Fe with low radial velocities indicative of a CSM nature. An X-ray analysis of this feature in a companion paper (Vink et al. 2024) supports its CSM nature and detects significant blue shifting, thereby placing the Green Monster on the near side, in front of the Cas A SN remnant. The most striking features of the Green Monster are dozens of almost perfectly circular 1" - 3" sized holes, most likely created by interaction between high-velocity SN ejecta material and the CSM. Further investigation is needed to understand whether these holes were formed by small 8000-10500 km/s N-rich ejecta knots that penetrated and advanced out ahead of the remnant's 5000 - 6000 km/s outer blastwave, or by narrow ejecta fingers that protrude into the forward-shocked CSM. The detection of the Green Monster provides further evidence of the highly asymmetric mass-loss that Cas A's progenitor star underwent prior to explosion., Comment: 28 pages, 12 figures, resubmitted to ApJL after minor revision, comments welcome
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- 2024
25. Trotterless Simulation of Open Quantum Systems for NISQ Quantum Devices
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Burdine, Colin and Blair, Enrique P.
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Quantum Physics - Abstract
The simulation of quantum systems is one of the flagship applications of near-term NISQ (noisy intermediate-scale quantum) computing devices. Efficiently simulating the rich, non-unitary dynamics of open quantum systems remains challenging on NISQ hardware. Current simulation methods for open quantum systems employ time-stepped Trotter product formulas ("Trotterization") which can scale poorly with respect to the simulation time and system dimension. Here, we propose a new simulation method based on the derivation of a Kraus operator series representation of the system. We identify a class of open quantum systems for which this method produces circuits of time-independent depth, which may serve as a desirable alternative to Trotterization, especially on NISQ devices., Comment: 21 pages, 13 figures
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- 2024
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26. Matrix Theory Reloaded: A BPS Road to Holography
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Blair, Chris D. A., Lahnsteiner, Johannes, Obers, Niels A., and Yan, Ziqi
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High Energy Physics - Theory - Abstract
We revisit the decoupling limits that lead to matrix theories on D-branes. We highlight the BPS nature of these limits, in which the target space geometry becomes non-Lorentzian and wrapped D-branes experience instantaneous gravitational forces. Applied to curved D-brane geometries, we show that a single BPS decoupling limit induces the bulk near-horizon limit leading to AdS/CFT. By consecutively applying two such limits, we systematically generate further examples of holography, including novel versions with non-Lorentzian bulk geometry. Uplifted to M-theory, we are led to a unified framework where each BPS decoupling limit corresponds to a Discrete Light Cone Quantisation (DLCQ). We conjecture that a DLCQ${}^n$/DLCQ${}^{m}$ correspondence, with $m>n$, captures the notion of holography in string theory. In particular, AdS${}_5$/CFT${}_4$ can be viewed as an example of DLCQ${}^0$/DLCQ${}^{1}$, with the extra DLCQ on the field theory side corresponding to the near-horizon limit in the bulk geometry. We further show that undoing these BPS decoupling limits can be viewed as deformations of matrix theories. We explain how these deformations are related to the $T\bar{T}$ deformation in two dimensions. In the context of holography, this allows us to view the ten-dimensional near-horizon brane geometry as an intrinsic deformation of the flat non-Lorentzian geometry that arises asymptotically. In field theoretic terms, these generalisations lead to $T\bar{T}$-like flow equations for the D$p$-brane DBI action., Comment: 76 pages + references; v2: references added, minor clarifications
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- 2024
27. Detection and suppression of epileptiform seizures via model-free control and derivatives in a noisy environment
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Join, Cédric, Jovellar, D. Blair, Delaleau, Emmanuel, and Fliess, Michel
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Electrical Engineering and Systems Science - Systems and Control ,Mathematics - Optimization and Control ,92-08, 93B52 - Abstract
Recent advances in control theory yield closed-loop neurostimulations for suppressing epileptiform seizures. These advances are illustrated by computer experiments which are easy to implement and to tune. The feedback synthesis is provided by an intelligent proportional-derivative (iPD) regulator associated to model-free control. This approach has already been successfully exploited in many concrete situations in engineering, since no precise computational modeling is needed. iPDs permit tracking a large variety of signals including high-amplitude epileptic activity. Those unpredictable pathological brain oscillations should be detected in order to avoid continuous stimulation, which might induce detrimental side effects. This is achieved by introducing a data mining method based on the maxima of the recorded signals. The real-time derivative estimation in a particularly noisy epileptiform environment is made possible due to a newly developed algebraic differentiator. The virtual patient is the Wendling model, i.e., a set of ordinary differential equations adapted from the Jansen-Rit neural mass model in order to generate epileptiform activity via appropriate values of excitation- and inhibition-related parameters. Several simulations, which lead to a large variety of possible scenarios, are discussed. They show the robustness of our control synthesis with respect to different virtual patients and external disturbances., Comment: 12th International Conference on Systems and Control (ICSC), Batna (Algeria), 3-5 November 2024
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- 2024
28. A Novel Technique for Tarsal Metatarsal Joint (TMTJ) Fusion using Calcaneal Precision Bone Graft: Reducing Morbidity Associated with Bone Graft Donor Site
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Blair P. Tweedie MBChB, MSc, Bsc, Sarah K. Ashford-Wilson, Karolina Mazur, Jayasree Ramas Ramaskandhan MPT, MSc, and Malik S. Siddique FRCS (T&O)
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Orthopedic surgery ,RD701-811 - Abstract
Category: Midfoot/Forefoot; Basic Sciences/Biologics; Other Introduction/Purpose: TMTJ fusion has long been used as a treatment for TMTJ disease. Bone grafting has been shown to potentially improve union rates and often the iliac crest as a donor site has been used to achieve this. Indications for bone grafting include severe disease with greater bone loss and deformity, multiple joints being fused or revision surgery. In our paper we report on our experience of TMTJ fusion using localised bone grafting from either the calcaneum or cuneiform. This incorporates a novel operative technique for graft placement which increases contact area for healing and restores foot biomechanics. This may also therefore reduce non-union rate. Additionally, this localised form of bone grafting avoids the morbidity associated with iliac crest donor sites providing a better tolerated procedure. Methods: Twenty patients were included between 2016 and 2019 who underwent fusion of 39 TMTJs in total. Of these 39 joints 9 were first, 16 were second and 14 were third TMTJ. Two of the first TMTJ Fusions were revisions with double plating and bone grafting for non union. Fourteen patients had standard bone grafting and donor sites were as follows; 7 calcaneal, 1 cuneiform, 6 iliac crest. Seven patients had excision of OA joint and bone graft using precision instruments and surgery using our described technique. Locking plates were used in all twenty patients. Post-operative care included a wound check at two weeks, non-weight- bearing in a cast for 6 weeks and then weight-bearing cast for a further 6 weeks. Patients were followed up in clinic to observe radiological and clinical union. Ct scanning employed when delayed union was suspected. Complications with wound healing and infection were also recorded. Results: 15 of patients were female with a mean age of 59. 38 out of 39 fused joints went on to unite. 10 patients were initially assessed in the Specialist Limb Service (SLS) clinic with gait analysis prior to surgery. One non-union was diagnosed on CT scan in the traditional bone graft technique group. Graft was harvested from iliac crest in this case. All other graft sites resulted in fusion of the joint. All seven patients (100%) who had excision and bone graft using precision bone instruments with the new technique had union without delay. One patient underwent removal of metalware due to prominence. This was a revision double plating case. There were no wound healing problems and no postoperative infections. 80% of patients were satisfied with the results of surgery and reported improvement in quality of life. Conclusion: TMTJ fusion with looking plates remains an appropriate treatment for TMTJ disease providing high rates of successful union. Local donor site for bone grafting does not generate inferior outcomes whilst avoiding the morbidity associated with iliac crest harvesting. Additionally, this work presents a novel technique using precision bone graft instruments and cylindrical bone graft to fuse the TMTJ in the presence of OA. This technique generates increased fusion surface area and may provide better restoration of normal foot biomechanics.
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- 2022
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29. Swift-BAT GUANO follow-up of gravitational-wave triggers in the third LIGO-Virgo-KAGRA observing run
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Raman, Gayathri, Ronchini, Samuele, Delaunay, James, Tohuvavohu, Aaron, Kennea, Jamie A., Parsotan, Tyler, Ambrosi, Elena, Bernardini, Maria Grazia, Campana, Sergio, Cusumano, Giancarlo, D'Ai, Antonino, D'Avanzo, Paolo, D'Elia, Valerio, De Pasquale, Massimiliano, Dichiara, Simone, Evans, Phil, Hartmann, Dieter, Kuin, Paul, Melandri, Andrea, O'Brien, Paul, Osborne, Julian P., Page, Kim, Palmer, David M., Sbarufatti, Boris, Tagliaferri, Gianpiero, Troja, Eleonora, Abac, A. G., Abbott, R., Abe, H., Abouelfettouh, I., Acernese, F., Ackley, K., Adamcewicz, C., Adhicary, S., Adhikari, N., Adhikari, R. X., Adkins, V. K., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Aguiar, O. D., Aguilar, I., Aiello, L., Ain, A., Akutsu, T., Albanesi, S., Alfaidi, R. A., Al-Jodah, A., Alléné, C., Allocca, A., Al-Shammari, S., Altin, P. A., Alvarez-Lopez, S., Amato, A., Amez-Droz, L., Amorosi, A., Amra, C., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Andia, M., Ando, M., Andrade, T., Andres, N., Andrés-Carcasona, M., Andrić, T., Anglin, J., Ansoldi, S., Antelis, J. M., Antier, S., Aoumi, M., Appavuravther, E. Z., Appert, S., Apple, S. K., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Aritomi, N., Armato, F., Arnaud, N., Arogeti, M., Aronson, S. M., Ashton, G., Aso, Y., Assiduo, M., Melo, S. Assis de Souza, Aston, S. M., Astone, P., Aubin, F., AultONeal, K., Avallone, G., Babak, S., Badaracco, F., Badger, C., Bae, S., Bagnasco, S., Bagui, E., Bai, Y., Baier, J. G., Bajpai, R., Baka, T., Ball, M., Ballardin, G., Ballmer, S. W., Banagiri, S., Banerjee, B., Bankar, D., Baral, P., Barayoga, J. C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Barthelmy, S. D., Barton, M. A., Bartos, I., Basak, S., Basalaev, A., Bassiri, R., Basti, A., Bawaj, M., Baxi, P., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Beirnaert, F., Bejger, M., Belardinelli, D., Bell, A. S., Benedetto, V., Beniwal, D., Benoit, W., Bentley, J. D., Yaala, M. Ben, Bera, S., Berbel, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Beroiz, M., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bevins, N., Bhandare, R., Bhardwaj, U., Bhatt, R., Bhattacharjee, D., Bhaumik, S., Bhowmick, S., Bianchi, A., Bilenko, I. A., Billingsley, G., Binetti, A., Bini, S., Birnholtz, O., Biscoveanu, S., Bisht, A., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Bobba, F., Bode, N., Bogaert, G., Boileau, G., Boldrini, M., Bolingbroke, G. N., Bolliand, A., Bonavena, L. D., Bondarescu, R., Bondu, F., Bonilla, E., Bonilla, M. S., Bonino, A., Bonnand, R., Booker, P., Borchers, A., Boschi, V., Bose, S., Bossilkov, V., Boudart, V., Boumerdassi, A., Bozzi, A., Bradaschia, C., Brady, P. R., Braglia, M., Branch, A., Branchesi, M., Breschi, M., Briant, T., Brillet, A., Brinkmann, M., Brockill, P., Brockmueller, E., Brooks, A. F., Brown, D. D., Brozzetti, M. L., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bucci, F., Buchanan, J., Bulashenko, O., Bulik, T., Bulten, H. J., Buonanno, A., Burtnyk, K., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. Cabourn, Cabras, G., Cabrita, R., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Santoro, G. Caneva, Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capistran, L. A., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlassara, M., Carlin, J. B., Carpinelli, M., Carrillo, G., Carter, J. J., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castaldi, G., Castro-Lucas, S. Y., Caudill, S., Cavaglià, M., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakraborty, P., Subrahmanya, S. Chalathadka, Chan, C., Chan, J. C. L., Chan, K. H. M., Chan, M., Chan, W. L., Chandra, K., Chang, R. -J., Chanial, P., Chao, S., Chapman-Bird, C., Charlton, E. L., Charlton, P., Chassande-Mottin, E., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chen, A., Chen, A. H. -Y., Chen, D., Chen, H., Chen, H. Y., Chen, K. H., Chen, X., Chen, Yi-Ru, Chen, Yanbei, Chen, Yitian, Cheng, H. P., Chessa, P., Cheung, H. T., Chia, H. Y., Chiadini, F., Chiang, C., Chiarini, G., Chiba, A., Chiba, R., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Chou, C., Choudhary, S., Christensen, N., Chua, S. S. Y., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Clara, F., Clark, J. A., Clarke, T. A., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P. -F., Colleoni, M., Collette, C. G., Collins, J., Colloms, S., Colombo, A., Colpi, M., Compton, C. M., Conti, L., Cooper, S. J., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Cornish, N. J., Corsi, A., Cortese, S., Costa, C. A., Cottingham, R., Coughlin, M. W., Couineaux, A., Coulon, J. -P., Countryman, S. T., Coupechoux, J. -F., Cousins, B., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Craig, K., Creed, R., Creighton, J. D. E., Creighton, T. D., Cremonese, P., Criswell, A. W., Crockett-Gray, J. C. G., Croquette, M., Crouch, R., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cuoco, E., Cusinato, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Dálya, G., D'Angelo, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darroch, K. E., Dartez, L. P., Dasgupta, A., Datta, S., Dattilo, V., Daumas, A., Davari, N., Dave, I., Davenport, A., Davier, M., Davies, T. F., Davis, D., Davis, L., Davis, M. C., Daw, E. J., Dax, M., De Bolle, J., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., Dell'Aquila, D., Del Pozzo, W., De Marco, F., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., DePergola, N., De Pietri, R., De Rosa, R., De Rossi, C., De Simone, R., Dhani, A., Dhurandhar, S., Diab, R., Díaz, M. C., Di Cesare, M., Dideron, G., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Diksha, D., Di Michele, A., Ding, J., Di Pace, S., Di Palma, I., Di Renzo, F., Divyajyoti, Dmitriev, A., Doctor, Z., Dohmen, E., Doleva, P. P., Donahue, L., D'Onofrio, L., Donovan, F., Dooley, K. L., Dooney, T., Doravari, S., Dorosh, O., Drago, M., Driggers, J. C., Drori, Y., Ducoin, J. -G., Dunn, L., Dupletsa, U., D'Urso, D., Duval, H., Duverne, P. -A., Dwyer, S. E., Eassa, C., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eichholz, J., Einsle, H., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Emma, M., Engelby, E., Engl, A. J., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etzel, T., Evans, M., Evstafyeva, T., Ewing, B. E., Ezquiaga, J. M., Fabrizi, F., Faedi, F., Fafone, V., Fairhurst, S., Fan, P. C., Farah, A. M., Farr, B., Farr, W. M., Favaro, G., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Fenyvesi, E., Ferguson, D. L., Ferrante, I., Ferreira, T. A., Fidecaro, F., Fiori, A., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Fleischer, S. M., Fleming, L. S., Floden, E., Foley, E. M., Fong, H., Font, J. A., Fornal, B., Forsyth, P. W. F., Franceschetti, K., Franchini, N., Frasca, S., Frasconi, F., Mascioli, A. Frattale, Frei, Z., Freise, A., Freitas, O., Frey, R., Frischhertz, W., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fuentes-Garcia, M., Fujii, S., Fukunaga, I., Fulda, P., Fyffe, M., Gabella, W. E., Gadre, B., Gair, J. R., Galaudage, S., Gallardo, S., Gallego, B., Gamba, R., Gamboa, A., Ganapathy, D., Ganguly, A., Gaonkar, S. G., Garaventa, B., Garcia-Bellido, J., García-Núñez, C., García-Quirós, C., Gardner, J. W., Gardner, K. A., Gargiulo, J., Garron, A., Garufi, F., Gasbarra, C., Gateley, B., Gayathri, V., Gemme, G., Gennai, A., George, J., George, R., Gerberding, O., Gergely, L., Ghadiri, N., Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Suprovo, Ghosh, Tathagata, Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gibson, D. T., Gier, C., Giri, P., Gissi, F., Gkaitatzis, S., Glanzer, J., Gleckl, A. E., Glotin, F., Godfrey, J., Godwin, P., Goebbels, N. L., Goetz, E., Golomb, J., Lopez, S. Gomez, Goncharov, B., González, G., Goodarzi, P., Goodwin-Jones, A. W., Gosselin, M., Göttel, A. S., Gouaty, R., Gould, D. W., Goyal, S., Grace, B., Grado, A., Graham, V., Granados, A. E., Granata, M., Granata, V., Argianas, L. 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E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tissino, J., Tiwari, A., Tiwari, Shubhanshu, Tiwari, Srishti, Tiwari, V., Todd, M. R., Toivonen, A. M., Toland, K., Tolley, A. E., Tomaru, T., Tomita, K., Tomura, T., Tong-Yu, C., Toriyama, A., Toropov, N., Torres-Forné, A., Torrie, C. I., Toscani, M., Melo, I. Tosta e, Tournefier, E., Trani, A. A., Trapananti, A., Travasso, F., Traylor, G., Trenado, J., Trevor, M., Tringali, M. C., Tripathee, A., Troiano, L., Trovato, A., Trozzo, L., Trudeau, R. J., Tsang, T. T. L., Tso, R., Tsuchida, S., Tsukada, L., Tsutsui, T., Turbang, K., Turconi, M., Turski, C., Ubach, H., Ubhi, A. S., Uchikata, N., Uchiyama, T., Udall, R. P., Uehara, T., Ueno, K., Unnikrishnan, C. S., Ushiba, T., Utina, A., Vacatello, M., Vahlbruch, H., Vaidya, N., Vajente, G., Vajpeyi, A., Valdes, G., Valencia, J., Valentini, M., Vallejo-Peña, S. A., Vallero, S., Valsan, V., van Bakel, N., van Beuzekom, M., van Dael, M., Brand, J. F. J. van den, Broeck, C. Van Den, Vander-Hyde, D. C., van der Sluys, M., Van de Walle, A., van Dongen, J., Vandra, K., van Haevermaet, H., van Heijningen, J. V., Vanosky, J., van Putten, M. H. P. M., van Ranst, Z., van Remortel, N., Vardaro, M., Vargas, A. F., Varma, V., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venikoudis, S., Venneberg, J., Verdier, P., Verkindt, D., Verma, B., Verma, P., Verma, Y., Vermeulen, S. M., Veske, D., Vetrano, F., Veutro, A., Vibhute, A. M., Viceré, A., Vidyant, S., Viets, A. D., Vijaykumar, A., Vilkha, A., Villa-Ortega, V., Vincent, E. T., Vinet, J. -Y., Viret, S., Virtuoso, A., Vitale, S., Vocca, H., Voigt, D., von Reis, E. R. G., von Wrangel, J. S. A., Vyatchanin, S. P., Wade, L. E., Wade, M., Wagner, K. J., Walet, R. C., Walker, M., Wallace, G. S., Wallace, L., Wang, H., Wang, J. Z., Wang, W. H., Wang, Z., Waratkar, G., Ward, R. L., Warner, J., Was, M., Washimi, T., Washington, N. Y., Watarai, D., Wayt, K. E., Weaver, B., Weaving, C. R., Webster, S. A., Weinert, M., Weinstein, A. J., Weiss, R., Weller, C. M., Weller, R. A., Wellmann, F., Wen, L., Weßels, P., Wette, K., Whelan, J. T., White, D. D., Whiting, B. F., Whittle, C., Wildberger, J. B., Wilk, O. S., Wilken, D., Willetts, K., Williams, D., Williams, M. J., Williams, N. S., Willis, J. L., Willke, B., Wils, M., Wipf, C. C., Woan, G., Woehler, J., Wofford, J. K., Wolfe, N. E., Wong, D., Wong, H. T., Wong, H. W. Y., Wong, I. C. F., Wright, J. L., Wright, M., Wu, C., Wu, D. S., Wu, H., Wysocki, D. M., Xiao, L., Xu, V. A., Xu, Y., Yadav, N., Yamamoto, H., Yamamoto, K., Yamamoto, M., Yamamoto, T. S., Yamamoto, T., Yamamura, S., Yamazaki, R., Yan, S., Yan, T., Yang, F. W., Yang, F., Yang, K. Z., Yang, L. -C., Yang, Y., Yarbrough, Z., Yeh, S. -W., Yelikar, A. B., Yeung, S. M. C., Yin, X., Yokoyama, J., Yokozawa, T., Yoo, J., Yu, H., Yuzurihara, H., Zadrożny, A., Zannelli, A. J., Zanolin, M., Zeeshan, M., Zelenova, T., Zendri, J. -P., Zeoli, M., Zerrad, M., Zevin, M., Zhang, A. C., Zhang, J., Zhang, L., Zhang, R., Zhang, T., Zhang, Y., Zhao, C., Zhao, Yue, Zhao, Yuhang, Zheng, Y., Zhong, H., Zhong, S., Zhou, R., Zhu, Z. -H., Zimmerman, A. B., Zucker, M. E., and Zweizig, J.
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Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology - Abstract
We present results from a search for X-ray/gamma-ray counterparts of gravitational-wave (GW) candidates from the third observing run (O3) of the LIGO-Virgo-KAGRA (LVK) network using the Swift Burst Alert Telescope (Swift-BAT). The search includes 636 GW candidates received in low latency, 86 of which have been confirmed by the offline analysis and included in the third cumulative Gravitational-Wave Transient Catalogs (GWTC-3). Targeted searches were carried out on the entire GW sample using the maximum--likelihood NITRATES pipeline on the BAT data made available via the GUANO infrastructure. We do not detect any significant electromagnetic emission that is temporally and spatially coincident with any of the GW candidates. We report flux upper limits in the 15-350 keV band as a function of sky position for all the catalog candidates. For GW candidates where the Swift-BAT false alarm rate is less than 10$^{-3}$ Hz, we compute the GW--BAT joint false alarm rate. Finally, the derived Swift-BAT upper limits are used to infer constraints on the putative electromagnetic emission associated with binary black hole mergers., Comment: 50 pages, 10 figures, 4 tables
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- 2024
30. A Culturally Enhanced Framework of Caring Assessments for Diverse Learners
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Blair Lehman, Jesse R. Sparks, Diego Zapata-Rivera, Jonathan Steinberg, and Carol Forsyth
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Most assessments adopt a one-size-fits-all approach to provide fair testing opportunities to all learners. However, this rigid approach to assessment may limit the ability for some learners to show what they know and can do. The Caring Assessments framework proposed a guide for the design and development of flexible, personalized, and adaptive assessments to provide each learner with the best opportunity to show what they know and can do. The original framework for caring assessments proposed that caring can be integrated into assessments by leveraging knowledge about learners' characteristics, behaviors, and learning context. Because we also recognize the critical role of acknowledging learners' cultures, identities, and social contexts to provide effective, caring support for all learners, in this paper we expand the framework to the Culturally Enhanced Caring Assessments framework to include personal, social, linguistic, and cultural aspects of learners and the contexts in which they learn. We discuss the culturally enhanced caring assessments framework and the need for further research to address the implementation challenges that can emerge when assessments are flexible, personalized, and adaptive.
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- 2024
31. BeefSD: An Integrated and Intensive Extension Curriculum for Beginning Beef Cattle Producers
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Krista A. Ehlert, Amanda D. Blair, Stacy Hadrick, and Ken Olson
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There is a strong need to increase the opportunities for and success of the next generation of beef cattle producers. South Dakota State University Extension provides a 2-year educational program called "beefSD;" the purpose is to provide producers with a holistic view of the beef industry, an appreciation for utilizing adaptive management to respond to challenges and opportunities, and skills to assess and manage factors that influence overall operation sustainability. The curriculum has four major components: (1) in person workshops, case studies, interactive webinars, and homework (2) out-of-state learning experiences, (3) ranch to rail program, and (4) networking and mentoring.
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- 2024
32. Best Practices in Teaching English Language Learners
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Blair Drader
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Teachers face many challenges, including that of educating English language learner (ELL) students. These students are often placed in regular classrooms and create extra demands on the classroom teacher. Many strategies can be employed with ELLs that relate to best teaching practices. Potential trouble areas are discussed, as are the strategies that classroom teachers may use in educating ELLs. When teachers use these best practices with their students, student achievement is increased and better academic results are obtained. Case study examples garnered from the writer's own teaching experiences serve as illustrations throughout this article.
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- 2024
33. 3D visualization processes for recreating and studying organismal form
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Duncan J. Irschick, Fredrik Christiansen, Neil Hammerschlag, Johnson Martin, Peter T. Madsen, Jeanette Wyneken, Annabelle Brooks, Adrian Gleiss, Sabrina Fossette, Cameron Siler, Tony Gamble, Frank Fish, Ursula Siebert, Jaymin Patel, Zhan Xu, Evangelos Kalogerakis, Joshua Medina, Atreyi Mukherji, Mark Mandica, Savvas Zotos, Jared Detwiler, Blair Perot, and George Lauder
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Ecology ,Biological sciences ,Zoology ,Evolutionary biology ,Science - Abstract
Summary: The study of biological form is a vital goal of evolutionary biology and functional morphology. We review an emerging set of methods that allow scientists to create and study accurate 3D models of living organisms and animate those models for biomechanical and fluid dynamic analyses. The methods for creating such models include 3D photogrammetry, laser and CT scanning, and 3D software. New multi-camera devices can be used to create accurate 3D models of living animals in the wild and captivity. New websites and virtual reality/augmented reality devices now enable the visualization and sharing of these data. We provide examples of these approaches for animals ranging from large whales to lizards and show applications for several areas: Natural history collections; body condition/scaling, bioinspired robotics, computational fluids dynamics (CFD), machine learning, and education. We provide two datasets to demonstrate the efficacy of CFD and machine learning approaches and conclude with a prospectus.
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- 2022
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34. How Family Needs Informed an Early Literacy Family Reading Program in Multilingual and Multicultural Miami-Dade County
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Melissa Baralt, Shayl F. Griffith, K. Lori Hanson, Nicolas André, Lisa Blair, and Daniel M. Bagner
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Haitian Creole, or Krey'ol, has a unique history because it is historically an oral language; however, significant efforts have been made to standardize its orthography and to promote its literacy base. It also comes from a diglossic society: Haitian Creole is spoken in familiar settings such as the home, while French is used in formal settings such as government spaces. While Haitian Creole is the source of national pride for many Haitians, it is unfortunately stigmatized by many, and many Haitians do not read or write in Haitian Creole. This brings up new questions regarding parents' needs within a literacy program. For example, it was unknown if Haitian families in Miami-Dade would want books in Haitian Creole for their children. As such, we also sought to examine how the family reading program Baralt et al. 729 could best support Haitian families' needs in addition to other minoritized families. To this end, the overall aims of this study were to: 1. Characterize the literacy environment of families in Miami-Dade County, including (a) books and supporting materials, (b) time spent engaging in shared reading, and (c) facilitators as well as barriers of reading. 2. Learn about Miami-Dade families' hopes and goals for their children's literacy, as well as their concerns and worries. 3. Identify family needs and preferences regarding the design of a family reading program, including (a) books, (b) guides, (c) trusted resources for support, and (d) preferred modes of communication between the program and participants.
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- 2024
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35. Circulating mature granzyme B+ T cells distinguish Crohn’s disease-associated axial spondyloarthritis from axial spondyloarthritis and Crohn’s disease
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Adam R. Lefferts, Emilie H. Regner, Andrew Stahly, Becky O’Rourke, Mark E. Gerich, Blair P. Fennimore, Frank I. Scott, Alison E. Freeman, Ken Jones, and Kristine A. Kuhn
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Crohn’s disease ,Inflammatory bowel disease ,Axial spondyloarthritis ,Ankylosing spondylitis ,Interferonopathy ,Cytotoxic T cells ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Axial spondyloarthritis (axSpA) has strong connections with intestinal inflammation as occurs in Crohn’s disease (CD). However, the immunologic mechanisms that distinguish axSpA, CD, and those with features of both diseases (CD-axSpA) are unknown. This study aimed to address this question by initial unbiased single cell RNA-sequencing (scRNAseq) on a pilot cohort followed by validating findings using flow cytometry and ELISA in a larger cohort. Methods Two individuals each with CD, axSpA, CD-axSpA, and healthy controls (HC) were recruited for a pilot discovery scRNAseq cohort, and the validation cohort consisted of 18 axSpA, 24 CD, 13 CD-axSpA, and 17 HC that was evaluated by flow cytometry on PBMCs and ELISAs for plasma cytokines. Results Uniquely, PBMCs from subjects with CD-axSpA demonstrated a significant increase in granzyme B+ T cells of both CD4+ and CD8+ lineages by both scRNAseq and flow cytometry. T cell maturation was also greater in those with CD-axSpA, particularly the CD4+ granzyme B+ population. Pathway analysis suggested increased interferon response genes in all immune cell populations within CD-axSpA. Although IFN-γ was elevated in the plasma of a subset of subjects with CD-axSpA, IL-6 was also significantly elevated. Conclusions Our findings support the presence of a chronic interferonopathy in subjects with CD-axSpA characterized by interferon signaling by pathway analysis and an expansion of mature, cytotoxic T cells. These data indicate fundamental immunological differences between CD-axSpA and both of the putative “parent” conditions, suggesting that it is a distinct disease with unique natural history and treatment needs.
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- 2021
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36. An isogenic cell line panel for sequence-based screening of targeted anticancer drugs
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Ashley L. Cook, Nicolas Wyhs, Surojit Sur, Blair Ptak, Maria Popoli, Laura Dobbyn, Tasos Papadopoulos, Chetan Bettegowda, Nickolas Papadopoulos, Bert Vogelstein, Shibin Zhou, and Kenneth W. Kinzler
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Biochemistry ,Cancer ,Biochemical analysis ,Science - Abstract
Summary: We describe the creation of an isogenic cell line panel representing common cancer pathways, with features optimized for high-throughput screening. More than 1,800 cell lines from three normal human cell lines were generated using CRISPR technologies. Surprisingly, most of these lines did not result in complete gene inactivation despite integration of sgRNA at the desired genomic site. A subset of the lines harbored biallelic disruptions of the targeted tumor suppressor gene, yielding a final panel of 100 well-characterized lines covering 19 frequently lost cancer pathways. This panel included genetic markers optimized for sequence-based ratiometric assays for drug-based screening assays. To illustrate the potential utility of this panel, we developed a high-throughput screen that identified Wee1 inhibitor MK-1775 as a selective growth inhibitor of cells with inactivation of TP53. These cell lines and screening approach should prove useful for researchers studying a variety of cellular and biochemical phenomena.
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- 2022
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37. A Novel Approach toward Less Invasive Multiomics Gut Analyses: a Pilot Study
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Adam J. Berlinberg, Ana Brar, Andrew Stahly, Mark E. Gerich, Blair P. Fennimore, Frank I. Scott, and Kristine A. Kuhn
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intestine ,metabolomics ,metatranscriptomics ,microbiome ,Microbiology ,QR1-502 - Abstract
ABSTRACT Newer ‘omics approaches, such as metatranscriptomics and metabolomics, allow functional assessments of the interaction(s) between the gut microbiome and the human host. However, in order to generate meaningful data with these approaches, the method of sample collection is critical. Prior studies have relied on expensive and invasive means toward sample acquisition, such as intestinal biopsy, while other studies have relied on easier methods of collection, such as fecal samples that do not necessarily represent those microbes in contact with the host. In this pilot study, we attempt to characterize a novel, minimally invasive method toward sampling the human microbiome using mucosal cytology brush sampling compared to intestinal gut biopsy samples on 5 healthy participants undergoing routine screening colonoscopy. We compared metatranscriptomic analyses between the two collection methods and identified increased taxonomic evenness and beta diversity in the cytology brush samples and similar community transcriptional profiles between the two methods. Metabolomics assessment demonstrated striking differences between the two methods, implying a difference in bacterial-derived versus human-absorbed metabolites. Put together, this study supports the use of microbiome sampling with cytology brushes, but caution must be exercised when performing metabolomics assessment, as this represents differential metabolite production but not absorption by the host. IMPORTANCE In order to generate meaningful metabolomic and microbiome data, the method of sample collection is critical. This study utilizes and compares two methods for intestinal tissue collection for evaluation of metabolites and microbiomes, finding that using a brush to sample the microbiome provides valuable data. However, for metabolomics assessment, biopsy samples may still be required.
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- 2022
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38. The lived experience of renal cachexia: An interpretive phenomenological analysis.
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Blair, Carolyn, Shields, Joanne, Mullan, Robert, Johnston, William, Davenport, Andrew, Fouque, Denis, Kalantar-Zadeh, Kamyar, Maxwell, Peter, McKeaveney, Clare, Noble, Helen, Porter, Sam, Seres, David, Slee, Adrian, Swaine, Ian, Witham, Miles, and Reid, Joanne
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Cachexia ,End-stage kidney disease ,Health ,Interpretative phenomenological analysis ,Kidney disease ,Lived experience ,Palliative care ,Qualitative - Abstract
BACKGROUND: Chronic kidney disease is common, affecting up to 13 % of the global population, and is predicted to become the fifth leading cause of life years lost by 2040. Individuals with end-stage kidney disease commonly develop complications such as protein-energy wasting and cachexia which further worsens their prognosis. The syndrome of renal cachexia is poorly understood, under-diagnosed and even if recognised has limited treatment options. OBJECTIVE: To explore the lived experience of renal cachexia for individuals with end-stage kidney disease and the interrelated experiences of their carers. DESIGN: This interpretive phenomenological study was designed to facilitate an in-depth exploration of how patients and carers experience of renal cachexia. To improve and document the quality, transparency, and consistency of patient and public involvement in this study the Guidance for Reporting Involvement of Patients and the Public-Short Format was followed. SETTING: The study was conducted across two nephrology directorates, within two healthcare trusts in the United Kingdom. PARTICIPANTS: Seven participants who met the inclusion criteria were recruited for this study, four patients (three female, one male) and three carers (two male, one female). METHODS: We employed a purposive sampling strategy. Data collection was conducted between July 2022 and December 2023. Interviews were semi-structured, audio-recorded, transcribed verbatim and analysed in six steps by two researchers using interpretive phenomenological analysis. Ethical approval was approved by the Office for Research Ethics Committees Northern Ireland (Reference: 22/NI/0107). RESULTS: Analysis generated six group experiential themes: the lived experience of appetite loss, functional decline and temporal coping, weight loss a visual metaphor of concern, social withdrawal and vulnerability, the emotional toll of eating challenges and psychological strain amidst a lack of information about cachexia. CONCLUSION: This is the first qualitative study exploring the lived experience of renal cachexia for patients and carers. Our study highlights that psycho-social and educational support is urgently needed. Additionally, healthcare professionals need better information provision to help them to recognise and respond to the needs of this population. Further research is required to develop models of holistic support which could help patients and carers cope with the impact of renal cachexia and optimally manage this syndrome within the family unit. REGISTRATION: N/A.
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- 2024
39. Adjuvant Trastuzumab Emtansine Versus Paclitaxel Plus Trastuzumab for Stage I Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: 5-Year Results and Correlative Analyses From ATEMPT.
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Tarantino, Paolo, Tayob, Nabihah, Villacampa, Guillermo, Dang, Chau, Yardley, Denise, Isakoff, Steven, Valero, Vicente, Faggen, Meredith, Mulvey, Therese, Bose, Ron, Weckstein, Douglas, Wolff, Antonio, Reeder-Hayes, Katherine, Rugo, Hope, Ramaswamy, Bhuvaneswari, Zuckerman, Dan, Hart, Lowell, Gadi, Vijayakrishna, Constantine, Michael, Cheng, Kit, Garrett, Audrey, Marcom, P, Albain, Kathy, DeFusco, Patricia, Tung, Nadine, Ardman, Blair, Nanda, Rita, Jankowitz, Rachel, Rimawi, Mothaffar, Abramson, Vandana, Pohlmann, Paula, Van Poznak, Catherine, Forero-Torres, Andres, Liu, Minetta, Ruddy, Kathryn, Waks, Adrienne, DeMeo, Michelle, Burstein, Harold, Partridge, Ann, DellOrto, Patrizia, Russo, Leila, Krause, Emma, Newhouse, Daniel, Kurt, Busem, Mittendorf, Elizabeth, Schneider, Bryan, Prat, Aleix, Winer, Eric, Krop, Ian, and Tolaney, Sara
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Humans ,Female ,Breast Neoplasms ,Receptor ,ErbB-2 ,Paclitaxel ,Ado-Trastuzumab Emtansine ,Middle Aged ,Antineoplastic Combined Chemotherapy Protocols ,Trastuzumab ,Chemotherapy ,Adjuvant ,Adult ,Neoplasm Staging ,Aged ,Disease-Free Survival - Abstract
PURPOSE: Long-term outcomes of patients with stage I human epidermal growth factor receptor 2 (HER2)-positive breast cancer receiving adjuvant trastuzumab emtansine (T-DM1) remain undefined, and prognostic predictors represent an unmet need. METHODS: In the ATEMPT phase II trial, patients with stage I centrally confirmed HER2-positive breast cancer were randomly assigned 3:1 to adjuvant T-DM1 for 1 year or paclitaxel plus trastuzumab (TH). Coprimary objectives were to compare the incidence of clinically relevant toxicities between arms and to evaluate invasive disease-free survival (iDFS) with T-DM1. Correlative analyses included the HER2DX genomic tool, multiomic evaluations of HER2 heterogeneity, and predictors of thrombocytopenia. RESULTS: After a median follow-up of 5.8 years, 11 iDFS events were observed in the T-DM1 arm, consistent with a 5-year iDFS of 97.0% (95% CI, 95.2 to 98.7). At 5 years, the recurrence-free interval (RFI) was 98.3% (95% CI, 97.0 to 99.7), the overall survival was 97.8% (95% CI, 96.3 to 99.3), and the breast cancer-specific survival was 99.4% (95% CI, 98.6 to 100). Comparable iDFS was observed with T-DM1 irrespective of tumor size, hormone receptor status, centrally determined HER2 immunohistochemical score, and receipt of T-DM1 for more or less than 6 months. Although ATEMPT was not powered for this end point, the 5-year iDFS in the TH arm was 91.1%. Among patients with sufficient tissue for HER2DX testing (n = 187), 5-year outcomes significantly differed according to HER2DX risk score, with better RFI (98.1% v 81.8%, hazard ratio [HR], 0.10, P = .01) and iDFS (96.3% v 81.8%, HR, 0.20, P = .047) among patients with HER2DX low-risk versus high-risk tumors, respectively. CONCLUSION: Adjuvant T-DM1 for 1 year leads to outstanding long-term outcomes for patients with stage I HER2-positive breast cancer. A high HER2DX risk score predicted a higher risk of recurrence in ATEMPT.
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- 2024
40. Integrating Audiovisual Immersion Into Pediatric Radiation Therapy Across Multiple Centers: Methodology, Timeliness, and Cost of the Audiovisual-Assisted Therapeutic Ambience in Radiation Therapy Prospective Multi-Institutional Trial.
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Oh, Justin, Skinner, Lawrie, Gutkin, Paulina, Jiang, Alice, Donaldson, Sarah, Loo, Billy, Wang, Yi, Ewongwo, Agnes, Bredfeldt, Jeremy, Breneman, John, Constine, Louis, Faught, Austin, Haas-Kogan, Daphne, Holmes, Jordan, Krasin, Matthew, Larkin, Charlene, Marcus, Karen, Maxim, Peter, McClelland, Shearwood, Murphy, Blair, Palmer, Joshua, Perkins, Stephanie, Shen, Colette, Terezakis, Stephanie, Bush, Karl, and Hiniker, Susan
- Abstract
PURPOSE: The Audiovisual-Assisted Therapeutic Ambience in Radiotherapy (AVATAR) trial was a prospective multicenter study (NCT03991156) examining the combination of video immersion with radiation therapy and was successfully conducted through the collaboration of pediatric radiation oncology teams at 10 institutions independent of any pre-existing consortium. We sought to analyze and report the methodology of trial conception and development, process map, and cost. METHODS AND MATERIALS: The study enrolled patients aged 3 to 10 years preparing to undergo radiation therapy, integrated the combination of AVATAR-based video immersion with radiation therapy at each institution, and offered AVATAR use as an alternative to anesthesia, with rates of anesthesia use and outcomes of serial standardized anxiety and quality-of-life assessments assessed among the 81 children enrolled. A process map was created based on the trial timeline with the following components: study development time (time from conception of the trial to the accrual of the first patient, including design phase, agreement and approval phase, and site preparation phase), and accrual duration time (time from the first to last accrual). Costs and institutional success rates were calculated. RESULTS: Time from inception of study to last accrual was 3.6 years (1313 days). The study development time was 417 days (31.7%), and accrual duration time was 896 days (68.3%), with the final 50% of accrual occurring in
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- 2024
41. Gaps or Hallucinations? Gazing into Machine-Generated Legal Analysis for Fine-grained Text Evaluations
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Hou, Abe Bohan, Jurayj, William, Holzenberger, Nils, Blair-Stanek, Andrew, and Van Durme, Benjamin
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Computer Science - Computation and Language ,Computer Science - Computers and Society - Abstract
Large Language Models (LLMs) show promise as a writing aid for professionals performing legal analyses. However, LLMs can often hallucinate in this setting, in ways difficult to recognize by non-professionals and existing text evaluation metrics. In this work, we pose the question: when can machine-generated legal analysis be evaluated as acceptable? We introduce the neutral notion of gaps, as opposed to hallucinations in a strict erroneous sense, to refer to the difference between human-written and machine-generated legal analysis. Gaps do not always equate to invalid generation. Working with legal experts, we consider the CLERC generation task proposed in Hou et al. (2024b), leading to a taxonomy, a fine-grained detector for predicting gap categories, and an annotated dataset for automatic evaluation. Our best detector achieves 67% F1 score and 80% precision on the test set. Employing this detector as an automated metric on legal analysis generated by SOTA LLMs, we find around 80% contain hallucinations of different kinds.
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- 2024
42. Graph Inspection for Robotic Motion Planning: Do Arithmetic Circuits Help?
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Bentert, Matthias, Salomao, Daniel Coimbra, Crane, Alex, Mizutani, Yosuke, Reidl, Felix, and Sullivan, Blair D.
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Computer Science - Robotics ,Computer Science - Data Structures and Algorithms - Abstract
We investigate whether algorithms based on arithmetic circuits are a viable alternative to existing solvers for Graph Inspection, a problem with direct application in robotic motion planning. Specifically, we seek to address the high memory usage of existing solvers. Aided by novel theoretical results enabling fast solution recovery, we implement a circuit-based solver for Graph Inspection which uses only polynomial space and test it on several realistic robotic motion planning datasets. In particular, we provide a comprehensive experimental evaluation of a suite of engineered algorithms for three key subroutines. While this evaluation demonstrates that circuit-based methods are not yet practically competitive for our robotics application, it also provides insights which may guide future efforts to bring circuit-based algorithms from theory to practice.
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- 2024
43. The Dark Energy Camera Magellanic Clouds Emission-Line Survey
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Points, Sean D., Long, Knox S., Blair, William P., Williams, Rosa, Chu, You-Hua, Winkler, P. Frank, White, Richard L., Rest, Armin, Li, Chuan-Jui, and Valdes, Francisco
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Astrophysics - Astrophysics of Galaxies - Abstract
We have used the Dark Energy Camera (DECam) on the CTIO Blanco 4-m telescope to perform a new emission-line survey of the Large Magellanic Cloud (LMC) using narrow-band H-alpha and [SII] filters in addition to a continuum band for use in creating pure emission-line images. We refer to this new survey as DeMCELS, to distinguish it from the earlier Magellanic Cloud Emission Line Survey (MCELS) that has been in service for nearly 25 years. DeMCELS covers $\sim 54$ degrees$^{2}$, encompassing most of the bright optical disk of the LMC. With DECam's pixel size of only 0.27", our DeMCELS survey provides a seeing-limited improvement of 3-5 times over MCELS and is comparable in depth, with surface brightness limits of 3.3E-17 erg cm$^{-2}$ s$^{-1}$ arcsec$^{-2}$ in H-alpha and 2.9E-17 erg cm$^{-2}$ s$^{-1}$ arcsec$^{-2}$ in H-alpha and [SII], respectively. DeMCELS provides detailed morphological information on nebulae of all scales, from the largest supershells to individual [HII] regions and supernova remnants, to bubbles of emission surrounding individual stars, and even to faint structures in the diffuse ionized gas of the LMC. Many complex regions of emission show significant variations in the ratio of [SII] to H-alpha, a sign of the mixture of shocks from stellar winds and/or supernovae with photoionization by embedded hot, young stars. We present the details of the observing strategy and data processing for this survey, and show selected results in comparison with previous data. A companion project for the Small Magellanic Cloud is in progress and will be reported separately. We are making these new data available to the community at large via the NOIRLab's Data Lab site., Comment: 30 pages, 16 figures Accepted for publication (ApJ)
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- 2024
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44. Fast algorithms to improve fair information access in networks
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Windham, Dennis Robert, Wendt, Caroline J., Crane, Alex, Friedler, Sorelle A., Sullivan, Blair D., and Clauset, Aaron
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Computer Science - Social and Information Networks ,Computer Science - Computers and Society ,Physics - Physics and Society - Abstract
When information spreads across a network via pairwise sharing, large disparities in information access can arise from the network's structural heterogeneity. Algorithms to improve the fairness of information access seek to maximize the minimum access of a node to information by sequentially selecting new nodes to seed with the spreading information. However, existing algorithms are computationally expensive. Here, we develop and evaluate a set of 10 new scalable algorithms to improve information access in social networks; in order to compare them to the existing state-of-the-art, we introduce both a new performance metric and a new benchmark corpus of networks. Additionally, we investigate the degree to which algorithm performance on minimizing information access gaps can be predicted ahead of time from features of a network's structure. We find that while no algorithm is strictly superior to all others across networks, our new scalable algorithms are competitive with the state-of-the-art and orders of magnitude faster. We introduce a meta-learner approach that learns which of the fast algorithms is best for a specific network and is on average only 20% less effective than the state-of-the-art performance on held-out data, while about 75-130 times faster. Furthermore, on about 20% of networks the meta-learner's performance exceeds the state-of-the-art., Comment: 9 pages, 9 figures, and 3 appendices containing 12 algorithms, 1 table, and 9 additional figures
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- 2024
45. Report Cards: Qualitative Evaluation of Language Models Using Natural Language Summaries
- Author
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Yang, Blair, Cui, Fuyang, Paster, Keiran, Ba, Jimmy, Vaezipoor, Pashootan, Pitis, Silviu, and Zhang, Michael R.
- Subjects
Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
The rapid development and dynamic nature of large language models (LLMs) make it difficult for conventional quantitative benchmarks to accurately assess their capabilities. We propose report cards, which are human-interpretable, natural language summaries of model behavior for specific skills or topics. We develop a framework to evaluate report cards based on three criteria: specificity (ability to distinguish between models), faithfulness (accurate representation of model capabilities), and interpretability (clarity and relevance to humans). We also propose an iterative algorithm for generating report cards without human supervision and explore its efficacy by ablating various design choices. Through experimentation with popular LLMs, we demonstrate that report cards provide insights beyond traditional benchmarks and can help address the need for a more interpretable and holistic evaluation of LLMs., Comment: 11 pages, 8 figures
- Published
- 2024
46. Preprocessing to Reduce the Search Space for Odd Cycle Transversal
- Author
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Jansen, Bart M. P., Mizutani, Yosuke, Sullivan, Blair D., and Verhaegh, Ruben F. A.
- Subjects
Computer Science - Data Structures and Algorithms - Abstract
The NP-hard Odd Cycle Transversal problem asks for a minimum vertex set whose removal from an undirected input graph $G$ breaks all odd cycles, and thereby yields a bipartite graph. The problem is well-known to be fixed-parameter tractable when parameterized by the size $k$ of the desired solution. It also admits a randomized kernelization of polynomial size, using the celebrated matroid toolkit by Kratsch and Wahlstr\"{o}m. The kernelization guarantees a reduction in the total $\textit{size}$ of an input graph, but does not guarantee any decrease in the size of the solution to be sought; the latter governs the size of the search space for FPT algorithms parameterized by $k$. We investigate under which conditions an efficient algorithm can detect one or more vertices that belong to an optimal solution to Odd Cycle Transversal. By drawing inspiration from the popular $\textit{crown reduction}$ rule for Vertex Cover, and the notion of $\textit{antler decompositions}$ that was recently proposed for Feedback Vertex Set, we introduce a graph decomposition called $\textit{tight odd cycle cut}$ that can be used to certify that a vertex set is part of an optimal odd cycle transversal. While it is NP-hard to compute such a graph decomposition, we develop parameterized algorithms to find a set of at least $k$ vertices that belong to an optimal odd cycle transversal when the input contains a tight odd cycle cut certifying the membership of $k$ vertices in an optimal solution. The resulting algorithm formalizes when the search space for the solution-size parameterization of Odd Cycle Transversal can be reduced by preprocessing. To obtain our results, we develop a graph reduction step that can be used to simplify the graph to the point that the odd cycle cut can be detected via color coding.
- Published
- 2024
47. Closed-loop underwater soft robotic foil shape control using flexible e-skin
- Author
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Micklem, Leo, Dong, Huazhi, Giorgio-Serchi, Francesco, Yang, Yunjie, Weymouth, Gabriel D., and Thornton, Blair
- Subjects
Computer Science - Robotics - Abstract
The use of soft robotics for real-world underwater applications is limited, even more than in terrestrial applications, by the ability to accurately measure and control the deformation of the soft materials in real time without the need for feedback from an external sensor. Real-time underwater shape estimation would allow for accurate closed-loop control of soft propulsors, enabling high-performance swimming and manoeuvring. We propose and demonstrate a method for closed-loop underwater soft robotic foil control based on a flexible capacitive e-skin and machine learning which does not necessitate feedback from an external sensor. The underwater e-skin is applied to a highly flexible foil undergoing deformations from 2% to 9% of its camber by means of soft hydraulic actuators. Accurate set point regulation of the camber is successfully tracked during sinusoidal and triangle actuation routines with an amplitude of 5% peak-to-peak and 10-second period with a normalised RMS error of 0.11, and 2% peak-to-peak amplitude with a period of 5 seconds with a normalised RMS error of 0.03. The tail tip deflection can be measured across a 30 mm (0.15 chords) range. These results pave the way for using e-skin technology for underwater soft robotic closed-loop control applications., Comment: 6 pages, 10 figures
- Published
- 2024
48. From Stem to Stern: Contestability Along AI Value Chains
- Author
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Balayn, Agathe, Pi, Yulu, Widder, David Gray, Alfrink, Kars, Yurrita, Mireia, Upadhyay, Sohini, Karusala, Naveena, Lyons, Henrietta, Turkay, Cagatay, Tessono, Christelle, Attard-Frost, Blair, and Gadiraju, Ujwal
- Subjects
Computer Science - Artificial Intelligence ,Computer Science - Computers and Society ,Computer Science - Human-Computer Interaction - Abstract
This workshop will grow and consolidate a community of interdisciplinary CSCW researchers focusing on the topic of contestable AI. As an outcome of the workshop, we will synthesize the most pressing opportunities and challenges for contestability along AI value chains in the form of a research roadmap. This roadmap will help shape and inspire imminent work in this field. Considering the length and depth of AI value chains, it will especially spur discussions around the contestability of AI systems along various sites of such chains. The workshop will serve as a platform for dialogue and demonstrations of concrete, successful, and unsuccessful examples of AI systems that (could or should) have been contested, to identify requirements, obstacles, and opportunities for designing and deploying contestable AI in various contexts. This will be held primarily as an in-person workshop, with some hybrid accommodation. The day will consist of individual presentations and group activities to stimulate ideation and inspire broad reflections on the field of contestable AI. Our aim is to facilitate interdisciplinary dialogue by bringing together researchers, practitioners, and stakeholders to foster the design and deployment of contestable AI., Comment: 5 pages, 0 figure, to be held as a workshop at CSCW'24
- Published
- 2024
49. The surprising structure of non-relativistic 11-dimensional supergravity
- Author
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Bergshoeff, Eric A., Blair, Chris D. A., Lahnsteiner, Johannes, and Rosseel, Jan
- Subjects
High Energy Physics - Theory - Abstract
We study a non-relativistic limit of 11-dimensional supergravity. This limit leads to a theory with an underlying membrane Newton-Cartan geometry. Consistency of the non-relativistic limit requires the imposition of constraints, requiring that certain bosonic and fermionic torsions and curvatures vanish. We investigate the implications of two versions of these constraints. In one version, we keep only 16 supersymmetry transformations, leading to a simple (purely bosonic) constraint structure but an unusual realisation of the supersymmetry algebra which does not close into diffeomorphisms. In the other, we keep all 32 supersymmetry transformations. This requires a complicated sequence of bosonic and fermionic constraints, eventually involving three derivatives of bosonic fields. We argue, with a linearised calculation, that this sequence of constraints terminates. Furthermore, we show that there exists a family of supersymmetric solutions satisfying these constraints, containing the non-relativistic limit of the M2 supergravity solution recently obtained by Lambert and Smith as a background relevant for non-relativistic holography., Comment: 57 pages, 2 figures. v2: matches published version
- Published
- 2024
50. Communicating the gravitational-wave discoveries of the LIGO-Virgo-KAGRA Collaboration
- Author
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Middleton, Hannah, Berry, Christopher P L, Arnaud, Nicolas, Blair, David, Bondell, Jacqueline, Bonino, Alice, Bonne, Nicolas, Chatterjee, Debarati, Chaty, Sylvain, Colloms, Storm, Cominsky, Lynn, Conti, Livia, Cordero-Carrión, Isabel, Coyne, Robert, Doctor, Zoheyr, Freise, Andreas, Geller, Aaron, Green, Anna C, Gupta, Jen, Holz, Daniel, Katzman, William, Kaur, Jyoti, Keitel, David, Key, Joey Shapiro, Kijbunchoo, Nutsinee, Knox, Carl, Krawczyk, Coleman, Lang, Ryan N, Larson, Shane L, Milde, Susanne, Napolano, Vincenzo, North, Chris, Rieger, Sascha, Rossi, Giada, Shinkai, Hisaaki, Simonnet, Aurore, and Spencer, Andrew
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology ,Physics - Physics Education ,Physics - Popular Physics - Abstract
The LIGO-Virgo-KAGRA (LVK) Collaboration has made breakthrough discoveries in gravitational-wave astronomy, a new field that provides a different means of observing our Universe. Gravitational-wave discoveries are possible thanks to the work of thousands of people from across the globe working together. In this article, we discuss the range of engagement activities used to communicate LVK gravitational-wave discoveries and the stories of the people behind the science, using the activities surrounding the release of the third Gravitational-Wave Transient Catalog as a case study., Comment: 15 pages, 7 figures, published in JCOM: https://doi.org/10.22323/2.23070803
- Published
- 2024
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