6 results on '"Blankenburgh, R."'
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2. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer
- Author
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de Boo, L W, Jóźwiak, K; https://orcid.org/0000-0002-9614-6586, Ter Hoeve, N D, van Diest, P J; https://orcid.org/0000-0003-0658-2745, Opdam, M; https://orcid.org/0000-0001-5832-6386, Wang, Y; https://orcid.org/0000-0002-1482-7039, Schmidt, M K; https://orcid.org/0000-0002-2228-429X, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D; https://orcid.org/0009-0004-6456-4857, van Dalen, T, Bins, A D, Beeker, A; https://orcid.org/0000-0003-4133-769X, van den Heiligenberg, S M, de Jong, P C, Bakker, S D; https://orcid.org/0000-0003-3936-4648, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M; https://orcid.org/0000-0003-0980-6652, Imholz, A L T, Stathonikos, N, Vreuls, W; https://orcid.org/0000-0001-6661-6017, Sanders, J, Rosenberg, E H; https://orcid.org/0000-0002-3859-6941, Koop, E A, Varga, Z; https://orcid.org/0000-0002-2855-983X, et al, de Boo, L W, Jóźwiak, K; https://orcid.org/0000-0002-9614-6586, Ter Hoeve, N D, van Diest, P J; https://orcid.org/0000-0003-0658-2745, Opdam, M; https://orcid.org/0000-0001-5832-6386, Wang, Y; https://orcid.org/0000-0002-1482-7039, Schmidt, M K; https://orcid.org/0000-0002-2228-429X, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D; https://orcid.org/0009-0004-6456-4857, van Dalen, T, Bins, A D, Beeker, A; https://orcid.org/0000-0003-4133-769X, van den Heiligenberg, S M, de Jong, P C, Bakker, S D; https://orcid.org/0000-0003-3936-4648, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M; https://orcid.org/0000-0003-0980-6652, Imholz, A L T, Stathonikos, N, Vreuls, W; https://orcid.org/0000-0001-6661-6017, Sanders, J, Rosenberg, E H; https://orcid.org/0000-0002-3859-6941, Koop, E A, Varga, Z; https://orcid.org/0000-0002-2855-983X, and et al
- Published
- 2024
3. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer
- Author
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Pathologie, Cancer, MMB opleiding Arts microbioloog, Neurogenetica, MS CGO, Public Health Practice, Affectieve & Psychotische Med., MS Medische Oncologie, Pathologie Support, Pathologie Pathologen staf, MS Reumatologie/Immunologie/Infectie, Speerpunt Cancer, KVO Docenten, de Boo, L W, Jóźwiak, K, Ter Hoeve, N D, van Diest, P J, Opdam, M, Wang, Y, Schmidt, M K, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D, van Dalen, T, Bins, A D, Beeker, A, van den Heiligenberg, S M, de Jong, P C, Bakker, S D, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M, Imholz, A L T, Stathonikos, N, Vreuls, W, Sanders, J, Rosenberg, E H, Koop, E A, Varga, Z, van Deurzen, C H M, Mooyaart, A L, Córdoba, A, Groen, E, Bart, J, Willems, S M, Zolota, V, Wesseling, J, Sapino, A, Chmielik, E, Ryska, A, Broeks, A, Voogd, A C, van der Wall, E, Siesling, S, Salgado, R, Dackus, G M H E, Hauptmann, M, Kok, M, Linn, S C, Pathologie, Cancer, MMB opleiding Arts microbioloog, Neurogenetica, MS CGO, Public Health Practice, Affectieve & Psychotische Med., MS Medische Oncologie, Pathologie Support, Pathologie Pathologen staf, MS Reumatologie/Immunologie/Infectie, Speerpunt Cancer, KVO Docenten, de Boo, L W, Jóźwiak, K, Ter Hoeve, N D, van Diest, P J, Opdam, M, Wang, Y, Schmidt, M K, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D, van Dalen, T, Bins, A D, Beeker, A, van den Heiligenberg, S M, de Jong, P C, Bakker, S D, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M, Imholz, A L T, Stathonikos, N, Vreuls, W, Sanders, J, Rosenberg, E H, Koop, E A, Varga, Z, van Deurzen, C H M, Mooyaart, A L, Córdoba, A, Groen, E, Bart, J, Willems, S M, Zolota, V, Wesseling, J, Sapino, A, Chmielik, E, Ryska, A, Broeks, A, Voogd, A C, van der Wall, E, Siesling, S, Salgado, R, Dackus, G M H E, Hauptmann, M, Kok, M, and Linn, S C
- Published
- 2024
4. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer
- Author
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de Boo, L. W., Jóźwiak, K., Ter Hoeve, N. D., van Diest, P. J., Opdam, M., Wang, Y., Schmidt, M. K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R. H.T., Kerver, E. D., van Dalen, T., Bins, A. D., Beeker, A., van den Heiligenberg, S. M., de Jong, P. C., Bakker, S. D., Rietbroek, R. C., Konings, I. R., Blankenburgh, R., Bijlsma, R. M., Imholz, A. L.T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E. H., Koop, E. A., Varga, Z., van Deurzen, C. H.M., Mooyaart, A. L., Córdoba, A., Groen, E., Bart, J., Willems, S. M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A. C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G. M.H.E., Hauptmann, M., Kok, M., Linn, S. C., de Boo, L. W., Jóźwiak, K., Ter Hoeve, N. D., van Diest, P. J., Opdam, M., Wang, Y., Schmidt, M. K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R. H.T., Kerver, E. D., van Dalen, T., Bins, A. D., Beeker, A., van den Heiligenberg, S. M., de Jong, P. C., Bakker, S. D., Rietbroek, R. C., Konings, I. R., Blankenburgh, R., Bijlsma, R. M., Imholz, A. L.T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E. H., Koop, E. A., Varga, Z., van Deurzen, C. H.M., Mooyaart, A. L., Córdoba, A., Groen, E., Bart, J., Willems, S. M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A. C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G. M.H.E., Hauptmann, M., Kok, M., and Linn, S. C.
- Abstract
Background: In the absence of prognostic biomarkers, most patients with early-stage triple-negative breast cancer (eTNBC) are treated with combination chemotherapy. The identification of biomarkers to select patients for whom treatment de-escalation or escalation could be considered remains an unmet need. We evaluated the prognostic value of histopathologic traits in a unique cohort of young, (neo)adjuvant chemotherapy-naïve patients with early-stage (stage I or II), node-negative TNBC and long-term follow-up, in relation to stromal tumor-infiltrating lymphocytes (sTILs) for which the prognostic value was recently reported. Materials and methods: We studied all 485 patients with node-negative eTNBC from the population-based PARADIGM cohort which selected women aged <40 years diagnosed between 1989 and 2000. None of the patients had received (neo)adjuvant chemotherapy according to standard practice at the time. Associations between histopathologic traits and breast cancer-specific survival (BCSS) were analyzed with Cox proportional hazard models. Results: With a median follow-up of 20.0 years, an independent prognostic value for BCSS was observed for lymphovascular invasion (LVI) [adjusted (adj.) hazard ratio (HR) 2.35, 95% confidence interval (CI) 1.49-3.69], fibrotic focus (adj. HR 1.61, 95% CI 1.09-2.37) and sTILs (per 10% increment adj. HR 0.75, 95% CI 0.69-0.82). In the sTILs <30% subgroup, the presence of LVI resulted in a higher cumulative incidence of breast cancer death (at 20 years, 58%; 95% CI 41% to 72%) compared with when LVI was absent (at 20 years, 32%; 95% CI 26% to 39%). In the ≥75% sTILs subgroup, the presence of LVI might be associated with poor survival (HR 11.45, 95% CI 0.71-182.36, two deaths). We confirm the lack of prognostic value of androgen receptor expression and human epidermal growth factor receptor 2 -low status. Conclusions: sTILs, LVI and fibrotic focus provide independent prognostic information in young women with node-negat
- Published
- 2024
5. The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care
- Author
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Derksen, J.W.G. (Jeroen W. G.), Vink, G.R. (Geraldine R.), Elferink, M.A.G. (Marloes), Roodhart, J.M. (Jeanine), Verkooijen, H.M. (Helena M.), Grevenstein, H.M.U. (Helma) van, Siersema, P.D. (Peter), May, A.M. (Anne M.), Koopman, M. (Miriam), Beets, G.L. (Geerard), Belt, E.J.T. (Eric), Berbée, M. (Maaike), Beverdam, F.H. (Frederique H.), Blankenburgh, R. (Ruud), Coene, P-P. (Peter Paul), van Cruijsen, H. (Hester), Dekker, J.W.T. (Jan Willem), van Dodewaard-de Jong, J.M. (Joyce M.), Erdkamp, F.L.G. (Frans ), Groot, J.W.B. (Jan Willem) de, Haringhuizen, A.W. (Annebeth W.), Helgason, H.H. (Helgi H.), Hendriks, M.P. (Mathijs P.), Hingh, I.H.J.T. (Ignace) de, Hoekstra, R. (Ronald), IJzermans, J.N.M. (Jan), Jansen, J. (Jan), Kloppenberg, F.W.H. (Frank W. H.), Lent, A.U. (Anja) van, Los, M., Meijerink, M.R. (Martijn R.), Mekenkamp, L.J.M. (Leonie J. M.), Nieboer, P. (Peter), Peeters, K.C.M.J. (Koen C.M.J.), Peters, N.A.J.B. (Natascha A. J. B.), Polee, M.B. (Marco), Pruijt, J.F.M., Punt, C.J.A. (Cornelis), van Ufford-Mannesse, P.Q. (Patricia Quarles), Rietbroek, R.C. (Ron), Schiphorst, A.H.W. (Anandi H. W.), van der Velden, A.S. (Arjan Schouten), Schrauwen, R.W.M. (Ruud W. M.), Sie, M.P.S. (Mark P. S.), Simkens, L.H.J. (L. H J), Sommeijer, D.W. (Dirkje W.), Sonneveld, D.J.A., Spierings, L.E.A. (Leontine E. A.), Stockmann, H.B.A.C. (Hein), Talsma, A.K. (Aaldert), Terheggen, F. (Frederiek), Tije, A.J. (Albert Jan) ten, Tjin-A-Ton, M.L.R. (Manuel L. R.), Valkenburg-van Iersel, L.B.J. (Liselot B. J.), Veenstra, R.P., Velden, A.M.T. van der, Vermaas, M. (Maarten), Vles, W., Vogelaar, J.F.J. (Jeroen F. J.), van Voorthuizen, T. (Theo), Vos, A.I. (Aad) de, Wegdam, J.A. (J.), Wilt, J.H.W. (Johannes) de, Zimmerman, D.D.E. (David), Derksen, J.W.G. (Jeroen W. G.), Vink, G.R. (Geraldine R.), Elferink, M.A.G. (Marloes), Roodhart, J.M. (Jeanine), Verkooijen, H.M. (Helena M.), Grevenstein, H.M.U. (Helma) van, Siersema, P.D. (Peter), May, A.M. (Anne M.), Koopman, M. (Miriam), Beets, G.L. (Geerard), Belt, E.J.T. (Eric), Berbée, M. (Maaike), Beverdam, F.H. (Frederique H.), Blankenburgh, R. (Ruud), Coene, P-P. (Peter Paul), van Cruijsen, H. (Hester), Dekker, J.W.T. (Jan Willem), van Dodewaard-de Jong, J.M. (Joyce M.), Erdkamp, F.L.G. (Frans ), Groot, J.W.B. (Jan Willem) de, Haringhuizen, A.W. (Annebeth W.), Helgason, H.H. (Helgi H.), Hendriks, M.P. (Mathijs P.), Hingh, I.H.J.T. (Ignace) de, Hoekstra, R. (Ronald), IJzermans, J.N.M. (Jan), Jansen, J. (Jan), Kloppenberg, F.W.H. (Frank W. H.), Lent, A.U. (Anja) van, Los, M., Meijerink, M.R. (Martijn R.), Mekenkamp, L.J.M. (Leonie J. M.), Nieboer, P. (Peter), Peeters, K.C.M.J. (Koen C.M.J.), Peters, N.A.J.B. (Natascha A. J. B.), Polee, M.B. (Marco), Pruijt, J.F.M., Punt, C.J.A. (Cornelis), van Ufford-Mannesse, P.Q. (Patricia Quarles), Rietbroek, R.C. (Ron), Schiphorst, A.H.W. (Anandi H. W.), van der Velden, A.S. (Arjan Schouten), Schrauwen, R.W.M. (Ruud W. M.), Sie, M.P.S. (Mark P. S.), Simkens, L.H.J. (L. H J), Sommeijer, D.W. (Dirkje W.), Sonneveld, D.J.A., Spierings, L.E.A. (Leontine E. A.), Stockmann, H.B.A.C. (Hein), Talsma, A.K. (Aaldert), Terheggen, F. (Frederiek), Tije, A.J. (Albert Jan) ten, Tjin-A-Ton, M.L.R. (Manuel L. R.), Valkenburg-van Iersel, L.B.J. (Liselot B. J.), Veenstra, R.P., Velden, A.M.T. van der, Vermaas, M. (Maarten), Vles, W., Vogelaar, J.F.J. (Jeroen F. J.), van Voorthuizen, T. (Theo), Vos, A.I. (Aad) de, Wegdam, J.A. (J.), Wilt, J.H.W. (Johannes) de, and Zimmerman, D.D.E. (David)
- Abstract
Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research collecting additional patient-reported outcomes (PRO) and biospecimens. Here we report on cohort developments and investigate to what extent PLCRC reflects the “real-world”. Clinical and demographic characteristics of PLCRC participants were compared with the general Dutch CRC population (n = 74,692, Dutch-ref). To study representativeness, standardized differences between PLCRC and Dutch-ref were calculated, and logistic regression models were evaluated on their ability to distinguish cohort participants from the Dutch-ref (AU-ROC 0.5 = preferred, implying participation independent of patient characteristics). Stratified analyses by stage and time-period (2013–2016 and 2017–Aug 2019) were performed to study the evolution towards RWD. In August 2019, 5744 patients were enrolled. Enrollment increased steeply, from 129 participants (1 hospital) in 2013 to 2136 (50 of 75 Dutch hospitals) in 2018. Low AU-ROC (0.65, 95% CI: 0.64–0.65) indicates limited ability to distinguish cohort participants from the Dutch-ref. Characteristics that remained imbalanced in the period 2017–Aug’19 compared with the Dutch-ref were age (65.0 years in PLCRC, 69.3 in the Dutch-ref) and tumor stage (40% stage-III in PLCRC, 30% in the Dutch-ref). PLCRC approaches to represent the Dutch CRC population and will ultimately meet the current demand for high-quality RWD. Efforts are ongoing to improve multidisciplinary recruitment which will further enhance PLCRC’s representativeness and its contribution to a learning healthcare system.
- Published
- 2021
- Full Text
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6. The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care
- Author
-
Derksen, JWG, Vink, GR, Elferink, MA, Roodhart, JML, Verkooijen, HM, van Grevenstein, WMU, Siersema, PD, May, AM, Koopman, M, Beets, GL, Belt, EJT, Berbée, M, Beverdam, FH, Blankenburgh, R, Coene, PPLO, Cruijsen, H, Dekker, JW, van Dodewaard-de Jong, JM, Erdkamp, FLG, Groot, JWH, Haringhuizen, AW, Helgason, HH, Hendriks, MP, de Hingh, IHJT, Hoekstra, R, IJzermans, J.N.M., Jansen, J, Kloppenberg, FWH, van Lent, AU, Los, M, Meijerink, MR, Mekenkamp, L J, Nieboer, P, Peeters, KCMJ, Peters, NA, Polée, MB, Pruijt, JFM, Punt, CJ, van Ufford-Mannesse, PQ, Rietbroek, RC, Schiphorst, AHW, van der Velden, AS, Schrauwen, RWM, Sie, MPS, Simkens, L, Sommeijer, DW, Sonneveld, DJA, Spierings, LEA, Stockmann, HB, Talsma, K, Terheggen, F, ten Tije, AJ, Tjin-a-Ton, MLR, Valkenburg-van Iersel, LBJ, Veenstra, RP, van der Velden, AMT, Vermaas, M, Vles, WJ, Vogelaar, JFJ, van Voorthuizen, T, Vos, AI, Wegdam, JA, Wilt, JHW, Zimmerman, DDE, Derksen, JWG, Vink, GR, Elferink, MA, Roodhart, JML, Verkooijen, HM, van Grevenstein, WMU, Siersema, PD, May, AM, Koopman, M, Beets, GL, Belt, EJT, Berbée, M, Beverdam, FH, Blankenburgh, R, Coene, PPLO, Cruijsen, H, Dekker, JW, van Dodewaard-de Jong, JM, Erdkamp, FLG, Groot, JWH, Haringhuizen, AW, Helgason, HH, Hendriks, MP, de Hingh, IHJT, Hoekstra, R, IJzermans, J.N.M., Jansen, J, Kloppenberg, FWH, van Lent, AU, Los, M, Meijerink, MR, Mekenkamp, L J, Nieboer, P, Peeters, KCMJ, Peters, NA, Polée, MB, Pruijt, JFM, Punt, CJ, van Ufford-Mannesse, PQ, Rietbroek, RC, Schiphorst, AHW, van der Velden, AS, Schrauwen, RWM, Sie, MPS, Simkens, L, Sommeijer, DW, Sonneveld, DJA, Spierings, LEA, Stockmann, HB, Talsma, K, Terheggen, F, ten Tije, AJ, Tjin-a-Ton, MLR, Valkenburg-van Iersel, LBJ, Veenstra, RP, van der Velden, AMT, Vermaas, M, Vles, WJ, Vogelaar, JFJ, van Voorthuizen, T, Vos, AI, Wegdam, JA, Wilt, JHW, and Zimmerman, DDE
- Abstract
Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research collecting additional patient-reported outcomes (PRO) and biospecimens. Here we report on cohort developments and investigate to what extent PLCRC reflects the “real-world”. Clinical and demographic characteristics of PLCRC participants were compared with the general Dutch CRC population (n = 74,692, Dutch-ref). To study representativeness, standardized differences between PLCRC and Dutch-ref were calculated, and logistic regression models were evaluated on their ability to distinguish cohort participants from the Dutch-ref (AU-ROC 0.5 = preferred, implying participation independent of patient characteristics). Stratified analyses by stage and time-period (2013–2016 and 2017–Aug 2019) were performed to study the evolution towards RWD. In August 2019, 5744 patients were enrolled. Enrollment increased steeply, from 129 participants (1 hospital) in 2013 to 2136 (50 of 75 Dutch hospitals) in 2018. Low AU-ROC (0.65, 95% CI: 0.64–0.65) indicates limited ability to distinguish cohort participants from the Dutch-ref. Characteristics that remained imbalanced in the period 2017–Aug’19 compared with the Dutch-ref were age (65.0 years in PLCRC, 69.3 in the Dutch-ref) and tumor stage (40% stage-III in PLCRC, 30% in the Dutch-ref). PLCRC approaches to represent the Dutch CRC population and will ultimately meet the current demand for high-quality RWD. Efforts are ongoing to improve multidisciplinary recruitment which will further enhance PLCRC’s representativeness and its contribution to a learning healthcare system.
- Published
- 2021
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