Search

Your search keyword '"Blantz, R."' showing total 270 results
Start Over Author "Blantz, R."
270 results on '"Blantz, R."'

4. Renal Hemodynamics in AKI: In Search of New Treatment Targets

Author

Matejovic, M., Ince, C., Chawla, L.S., Blantz, R., Molitoris, B.A., Rosner, M.H., Okusa, M.D., Kellum, J.A., Ronco, C., Pickkers, P., ACS - Amsterdam Cardiovascular Sciences, Translational Physiology, and Intensive Care

Subjects
0301 basic medicine, medicine.medical_specialty, Biomedical Research, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], 030232 urology & nephrology, Hemodynamics, Renal function, Nephron, urologic and male genital diseases, Renal Circulation, 03 medical and health sciences, 0302 clinical medicine, Up Front Matters, medicine, Humans, Intensive care medicine, Tubuloglomerular feedback, Kidney, Renal circulation, business.industry, Acute kidney injury, General Medicine, Blood flow, Acute Kidney Injury, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Nephrology, business
Abstract

Contains fulltext : 171381.pdf (Publisher’s version ) (Closed access) Novel therapeutic interventions are required to prevent or treat AKI. To expedite progress in this regard, a consensus conference held by the Acute Dialysis Quality Initiative was convened in April of 2014 to develop recommendations for research priorities and future directions. Here, we highlight the concepts related to renal hemodynamics in AKI that are likely to reveal new treatment targets on investigation. Overall, we must better understand the interactions between systemic, total renal, and glomerular hemodynamics, including the role of tubuloglomerular feedback. Furthermore, the net consequences of therapeutic maneuvers aimed at restoring glomerular filtration need to be examined in relation to the nature, magnitude, and duration of the insult. Additionally, microvascular blood flow heterogeneity in AKI is now recognized as a common occurrence; timely interventions to preserve the renal microcirculatory flow may interrupt the downward spiral of injury toward progressive kidney failure and should, therefore, be investigated. Finally, development of techniques that permit an integrative physiologic approach, including direct visualization of renal microvasculature and measurement of oxygen kinetics and mitochondrial function in intact tissue in all nephron segments, may provide new insights into how the kidney responds to various injurious stimuli and allow evaluation of new therapeutic strategies.

Published
2016
Full Text
View/download PDF

5. Glomerular hemodynamic alterations during acute hyperinsulinemia in normal and diabetic rats

Author

Tucker, B. J, Anderson, C. M, Thies, R. S, Collins, R. C, and Blantz, R. C

Subjects
Life Sciences (General)
Abstract

Treatment of insulin dependent diabetes invariably requires exogenous insulin to control blood glucose. Insulin treatment, independent of other factors associated with insulin dependent diabetes, may induce changes that affect glomerular function. Due to exogenous delivery of insulin in insulin dependent diabetes entering systemic circulation prior to the portal vein, plasma levels of insulin are often in excess of that observed in non-diabetics. The specific effects of hyperinsulinemia on glomerular hemodynamics have not been previously examined. Micropuncture studies were performed in control (non-diabetic), untreated diabetic and insulin-treated diabetic rats 7 to 10 days after administration of 65 mg/kg body weight streptozotocin. After the first period micropuncture measurements were obtained, 5 U of regular insulin (Humulin-R) was infused i.v., and glucose clamped at euglycemic values (80 to 120 mg/dl). Blood glucose concentration in non-diabetic controls was 99 +/- 6 mg/dl. In control rats, insulin infusion and glucose clamp increased nephron filtration rate due to decreases in both afferent and efferent arteriolar resistance (afferent greater than efferent) resulting in increased plasma flow and increased glomerular hydrostatic pressure gradient. However, insulin infusion and glucose clamp produced the opposite effect in both untreated and insulin-treated diabetic rats with afferent arteriolar vasoconstriction resulting in decreases in plasma flow, glomerular hydrostatic pressure gradient and nephron filtration rate. Thromboxane A2 (TX) synthetase inhibition partially decreased the vasoconstrictive response due to acute insulin infusion in diabetic rats preventing the decrease in nephron filtration rate.(ABSTRACT TRUNCATED AT 250 WORDS).

Published
1992

6. Interaction between alpha 2-adrenergic and angiotensin II systems in the control of glomerular hemodynamics as assessed by renal micropuncture in the rat

Author

Thomson, S. C, Gabbai, F. B, Tucker, B. J, and Blantz, R. C

Subjects
Life Sciences (General)
Abstract

The hypothesis that renal alpha 2 adrenoceptors influence nephron filtration rate (SNGFR) via interaction with angiotensin II (AII) was tested by renal micropuncture. The physical determinants of SNGFR were assessed in adult male Munich Wistar rats 5-7 d after ipsilateral surgical renal denervation (DNX). DNX was performed to isolate inhibitory central and presynaptic alpha 2 adrenoceptors from end-organ receptors within the kidney. Two experimental protocols were employed: one to test whether prior AII receptor blockade with saralasin would alter the glomerular hemodynamic response to alpha 2 adrenoceptor stimulation with the selective agonist B-HT 933 under euvolemic conditions, and the other to test whether B-HT 933 would alter the response to exogenous AII under conditions of plasma volume expansion. In euvolemic rats, B-HT 933 caused SNGFR to decline as the result of a decrease in glomerular ultrafiltration coefficient (LpA), an effect that was blocked by saralasin. After plasma volume expansion, B-HT 933 showed no primary effect on LpA but heightened the response of arterial blood pressure, glomerular transcapillary pressure gradient, and LpA to AII. The parallel results of these converse experiments suggest a complementary interaction between renal alpha 2-adrenergic and AII systems in the control of LpA.

Published
1992

16. Nephrology core curriculum. The American Society of Nephrology and the American Society of Nephrology Training Program Directors Committee.

Author

Kumar, R, primary, Alpern, R, additional, Berl, T, additional, Blantz, R, additional, Chevalier, R, additional, Hostetter, T, additional, Madias, N, additional, Salant, D, additional, Wiggins, R, additional, Bennett, W, additional, Chapman, A, additional, Ekonyan, G, additional, Falk, R, additional, Gennari, F J, additional, Helderman, J H, additional, Hruska, K, additional, Levey, A, additional, Lindheimer, M, additional, Miller, R, additional, Nissenson, A, additional, Schwab, S, additional, Schwab, T, additional, Schwartz, R, additional, and Wilcox, C, additional

Published
1997
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results