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12 results on '"Bleck, Dennis"'

1. Fibroblast‐like synoviocytes preferentially induce terminal differentiation of IgD+ memory B cells instead of naïve B cells.

Author

Bleck, Dennis, Loacker‐Schöch, Klara, Classen, Tim, Jose, Joachim, Schneider, Matthias, and Pongratz, Georg

Subjects
*PLASMA cells, *IMMUNOLOGIC memory, *B cells, *JOINT pain, *ANTIBODY formation
Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease driven by highly active autoantibody‐producing B cells. Activation of B cells is maintained within ectopic germinal centres found in affected joints. Fibroblast‐like synoviocytes (FLS) present in inflamed joints support B‐cell survival, activation, and differentiation. CD27+ memory B cells and naive B cells show very different responses to activation, particularly by CD40 ligand (CD40L). We show that FLS‐dependent activation of human B cells is dependent on interleukin‐6 (IL‐6) and CD40L. FLS have been shown to activate both naive and memory B cells. Whether the activating potential of FLS is different for naive and memory B cells has not been investigated. Our results suggest that FLS‐induced activation of B cells is dependent on IL‐6 and CD40L. While FLS are able to induce plasma cell differentiation, isotype switching, and antibody production in memory B cells, the ability of FLS to activate naive B cells is significantly lower. [ABSTRACT FROM AUTHOR]

Published
2024
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4. The role of Immunoglobulins D, G and M (IgD, G, M) in Fibroblast like synoviocyte (FLS) dependent B cell activation and class switch recombination (CSR)

Author

Bleck, Dennis, Schneider, Matthias, and Pongratz, Georg

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: FLS are capable of inducing class switch recombination (CSR) in naïve B cells. Isotype switch towards IgG is heavily favored. These IgG switched B cells are highly activated and secrete large amounts of IgG. Contrary to this IgG induction, FLS are also capable of supporting a non-naïve,[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2021
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5. Vascular smooth muscle cells of human aorta express CXCL17 - a possible mechanism for cell recruitment in GCA

Author

Kernder, Anna Luise, Mucke, Johanna, Tang-Chieu, Long, Bleck, Dennis, Lowin, Torsten, Akhyari, Payam, Bleck, Ellen, Heier, Claudia, Pongratz, Georg, Schneider, Matthias, and Vordenbäumen, Stefan

Subjects
ddc: 610, immune system diseases, cardiovascular system, cardiovascular diseases, 610 Medical sciences, Medicine, skin and connective tissue diseases
Abstract

Introduction: Giant cell arteritis (GCA) is characterized by an increased release of IFN-γ by Th1 cells and dendritic cells accompanied by an invasion of lymphocytes, dendritic cells and monocytes. The mechanisms contributing to cellular trafficking in GCA are incompletely understood. The most[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

Published
2020

6. Fibroblast like synoviocytes (FLS) are capable of inducing class switch recombination (CSR) in naive B cells from healthy donors; the process appears to be IL-6 and CD40L dependent

Author

Bleck, Dennis, Pongratz, Georg, Schneider, Matthias, and Lowin, Torsten

Subjects
musculoskeletal diseases, ddc: 610, 610 Medical sciences, Medicine
Abstract

Background: Rheumatoid Arthritis (RA) is a disease characterized by chronic inflammation of the synovial tissue in joints. It is driven by highly activated B cells. Synovial cells, primarily Fibroblast like synoviocytes (FLS) play an important role in activating these B cells. It was previously shown,[for full text, please go to the a.m. URL], 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2019

7. Adenosine A3-Rezeptor is upregulated in human SLE B cells

Author

Siekierka-Harreis, Magdalena, Schallehn, Merle, Honke, Nadine, Krebber, Katharina, Bleck, Dennis, Chehab, Gamal, Richter, Jutta, Schneider, Matthias, and Pongratz, Georg

Subjects
ddc: 610, immune system diseases, 610 Medical sciences, Medicine, skin and connective tissue diseases
Abstract

Background: Systemic Lupus Erythematosus (SLE) is a chronic, multisystem autoimmune disorder with dysregulation in many parts of the immune cascade. Purinergic signalling is well known to regulate immune cell functions. Adenosine plays an important role in animal models and human pathogenesis of arthritis,[for full text, please go to the a.m. URL], 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2019
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11. Differential influence of synovial fibroblasts from osteoarthritis vs. rheumatoid arthritis patients on B cell survival and immunoglobulin production

Author

Bleck, Dennis, Lowin, Torsten, Schneider, Matthias, and Pongratz, Georg

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Background: Rheumatoid Arthritis (RA) is a disease characterized by chronic inflammation of the synovial tissue in joints. It is driven by highly activated B cells. Synovial cells, primarily synovial Fibroblasts (SF) play an important role in activating these B cells. In order to investigate the interactions[for full text, please go to the a.m. URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2017
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12. Fibroblast-like synoviocytes preferentially induce terminal differentiation of IgD + memory B cells instead of naïve B cells.

Author

Bleck D, Loacker-Schöch K, Classen T, Jose J, Schneider M, and Pongratz G

Subjects
Humans, B-Lymphocytes immunology, CD40 Ligand metabolism, CD40 Ligand immunology, Cells, Cultured, Immunoglobulin Class Switching, Immunologic Memory, Interleukin-6 metabolism, Lymphocyte Activation, Tumor Necrosis Factor Receptor Superfamily, Member 7 metabolism, Arthritis, Rheumatoid immunology, Arthritis, Rheumatoid pathology, Arthritis, Rheumatoid metabolism, Cell Differentiation immunology, Fibroblasts immunology, Fibroblasts metabolism, Immunoglobulin D metabolism, Immunoglobulin D immunology, Memory B Cells immunology, Memory B Cells metabolism, Synoviocytes immunology, Synoviocytes metabolism
Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease driven by highly active autoantibody-producing B cells. Activation of B cells is maintained within ectopic germinal centres found in affected joints. Fibroblast-like synoviocytes (FLS) present in inflamed joints support B-cell survival, activation, and differentiation. CD27+ memory B cells and naive B cells show very different responses to activation, particularly by CD40 ligand (CD40L). We show that FLS-dependent activation of human B cells is dependent on interleukin-6 (IL-6) and CD40L. FLS have been shown to activate both naive and memory B cells. Whether the activating potential of FLS is different for naive and memory B cells has not been investigated. Our results suggest that FLS-induced activation of B cells is dependent on IL-6 and CD40L. While FLS are able to induce plasma cell differentiation, isotype switching, and antibody production in memory B cells, the ability of FLS to activate naive B cells is significantly lower., (© 2024 The Author(s). Immunology published by John Wiley & Sons Ltd.)

Published
2024
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