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2. Functional connectivity development along the sensorimotor-association axis enhances the cortical hierarchy

Author

Luo, Audrey C., Sydnor, Valerie J., Pines, Adam, Larsen, Bart, Alexander-Bloch, Aaron F., Cieslak, Matthew, Covitz, Sydney, Chen, Andrew A., Esper, Nathalia Bianchini, Feczko, Eric, Franco, Alexandre R., Gur, Raquel E., Gur, Ruben C., Houghton, Audrey, Hu, Fengling, Keller, Arielle S., Kiar, Gregory, Mehta, Kahini, Salum, Giovanni A., Tapera, Tinashe, Xu, Ting, Zhao, Chenying, Salo, Taylor, Fair, Damien A., Shinohara, Russell T., Milham, Michael P., and Satterthwaite, Theodore D.

Published
2024
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3. Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes

Author

Warrier, Varun, Stauffer, Eva-Maria, Huang, Qin Qin, Wigdor, Emilie M., Slob, Eric A. W., Seidlitz, Jakob, Ronan, Lisa, Valk, Sofie L., Mallard, Travis T., Grotzinger, Andrew D., Romero-Garcia, Rafael, Baron-Cohen, Simon, Geschwind, Daniel H., Lancaster, Madeline A., Murray, Graham K., Gandal, Michael J., Alexander-Bloch, Aaron, Won, Hyejung, Martin, Hilary C., Bullmore, Edward T., and Bethlehem, Richard A. I.

Published
2023
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4. Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder

Author

Adamson, Chris, Adler, Sophie, Alexander-Bloch, Aaron F., Anagnostou, Evdokia, Anderson, Kevin M., Areces-Gonzalez, Ariosky, Astle, Duncan E., Auyeung, Bonnie, Ayub, Muhammad, Bae, Jong Bin, Ball, Gareth, Baron-Cohen, Simon, Beare, Richard, Bedford, Saashi A., Benegal, Vivek, Bethlehem, Richard A.I., Beyer, Frauke, Blangero, John, Cábez, Manuel Blesa, Boardman, James P., Borzage, Matthew, Bosch-Bayard, Jorge F., Bourke, Niall, Bullmore, Edward T., Calhoun, Vince D., Chakravarty, Mallar M., Chen, Christina, Chertavian, Casey, Chetelat, Gaël, Chong, Yap S., Corvin, Aiden, Costantino, Manuela, Courchesne, Eric, Crivello, Fabrice, Cropley, Vanessa L., Crosbie, Jennifer, Crossley, Nicolas, Delarue, Marion, Delorme, Richard, Desrivieres, Sylvane, Devenyi, Gabriel, Di Biase, Maria A., Dolan, Ray, Donald, Kirsten A., Donohoe, Gary, Dorfschmidt, Lena, Dunlop, Katharine, Edwards, Anthony D., Elison, Jed T., Ellis, Cameron T., Elman, Jeremy A., Eyler, Lisa, Fair, Damien A., Fletcher, Paul C., Fonagy, Peter, Franz, Carol E., Galan-Garcia, Lidice, Gholipour, Ali, Giedd, Jay, Gilmore, John H., Glahn, David C., Goodyer, Ian M., Grant, P.E., Groenewold, Nynke A., Gudapati, Shreya, Gunning, Faith M., Gur, Raquel E., Gur, Ruben C., Hammill, Christopher F., Hansson, Oskar, Hedden, Trey, Heinz, Andreas, Henson, Richard N., Heuer, Katja, Hoare, Jacqueline, Holla, Bharath, Holmes, Avram J., Huang, Hao, Ipser, Jonathan, Jack, Clifford R., Jr., Jackowski, Andrea P., Jia, Tianye, Jones, David T., Jones, Peter B., Kahn, Rene S., Karlsson, Hasse, Karlsson, Linnea, Kawashima, Ryuta, Kelley, Elizabeth A., Kern, Silke, Kim, Ki-Woong, Kitzbichler, Manfred G., Kremen, William S., Lalonde, François, Landeau, Brigitte, Lerch, Jason, Lewis, John D., Li, Jiao, Liao, Wei, Liston, Conor, Lombardo, Michael V., Lv, Jinglei, Mallard, Travis T., Marcelis, Machteld, Mathias, Samuel R., Mazoyer, Bernard, McGuire, Philip, Meaney, Michael J., Mechelli, Andrea, Misic, Bratislav, Morgan, Sarah E., Mothersill, David, Ortinau, Cynthia, Ossenkoppele, Rik, Ouyang, Minhui, Palaniyappan, Lena, Paly, Leo, Pan, Pedro M., Pantelis, Christos, Park, Min Tae M., Paus, Tomas, Pausova, Zdenka, Paz-Linares, Deirel, Binette, Alexa Pichet, Pierce, Karen, Qian, Xing, Qiu, Anqi, Raznahan, Armin, Rittman, Timothy, Rodrigue, Amanda, Rollins, Caitlin K., Romero-Garcia, Rafael, Ronan, Lisa, Rosenberg, Monica D., Rowitch, David H., Salum, Giovanni A., Satterthwaite, Theodore D., Schaare, H. Lina, Schabdach, Jenna, Schachar, Russell J., Schöll, Michael, Schultz, Aaron P., Seidlitz, Jakob, Sharp, David, Shinohara, Russell T., Skoog, Ingmar, Smyser, Christopher D., Sperling, Reisa A., Stein, Dan J., Stolicyn, Aleks, Suckling, John, Sullivan, Gemma, Thyreau, Benjamin, Toro, Roberto, Traut, Nicolas, Tsvetanov, Kamen A., Turk-Browne, Nicholas B., Tuulari, Jetro J., Tzourio, Christophe, Vachon-Presseau, Étienne, Valdes-Sosa, Mitchell J., Valdes-Sosa, Pedro A., Valk, Sofie L., van Amelsvoort, Therese, Vandekar, Simon N., Vasung, Lana, Vértes, Petra E., Victoria, Lindsay W., Villeneuve, Sylvia, Villringer, Arno, Vogel, Jacob W., Wagstyl, Konrad, Wang, Yin-Shan S., Warfield, Simon K., Warrier, Varun, Westman, Eric, Westwater, Margaret L., Whalley, Heather C., White, Simon R., Witte, A. Veronica, Yang, Ning, Yeo, B.T. Thomas, Yun, Hyuk Jin, Zalesky, Andrew, Zar, Heather J., Zettergren, Anna, Zhou, Juan H., Ziauddeen, Hisham, Zimmerman, Dabriel, Zugman, Andre, Zuo, Xi-Nian N., Ho, Natalie C.W., Nogovitsyn, Nikita, Metzak, Paul, Ballester, Pedro L., Hassel, Stefanie, Rotzinger, Susan, Poppenk, Jordan, Lam, Raymond W., Taylor, Valerie H., Milev, Roumen, Frey, Benicio N., Harkness, Kate L., Addington, Jean, and Kennedy, Sidney H.

Published
2024
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5. Personalized functional brain network topography is associated with individual differences in youth cognition

Author

Keller, Arielle S., Pines, Adam R., Shanmugan, Sheila, Sydnor, Valerie J., Cui, Zaixu, Bertolero, Maxwell A., Barzilay, Ran, Alexander-Bloch, Aaron F., Byington, Nora, Chen, Andrew, Conan, Gregory M., Davatzikos, Christos, Feczko, Eric, Hendrickson, Timothy J., Houghton, Audrey, Larsen, Bart, Li, Hongming, Miranda-Dominguez, Oscar, Roalf, David R., Perrone, Anders, Shetty, Alisha, Shinohara, Russell T., Fan, Yong, Fair, Damien A., and Satterthwaite, Theodore D.

Published
2023
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7. Brain-Charting Autism and Attention-Deficit/Hyperactivity Disorder Reveals Distinct and Overlapping Neurobiology

Author

Bailey, Anthony J., Baron-Cohen, Simon, Bolton, Patrick F., Bullmore, Edward T., Carrington, Sarah, Catani, Marco, Chakrabarti, Bhismadev, Craig, Michael C., Daly, Eileen M., Deoni, Sean C.L., Ecker, Christine, Happé, Francesca, Henty, Julian, Jezzard, Peter, Johnston, Patrick, Jones, Derek K., Lai, Meng-Chuan, Lombardo, Michael V., Madden, Anya, Mullins, Diane, Murphy, Clodagh M., Murphy, Declan G.M., Pasco, Greg, Ruigrok, Amber N.V., Sadek, Susan A., Spain, Debbie, Stewart, Rose, Suckling, John, Wheelwright, Sally J., Williams, Steven C., Bedford, Saashi A., Ruigrok, Amber, Anagnostou, Evdokia, Lerch, Jason P., Taylor, Margot, Nicolson, Rob, Stelios, Georgiades, Crosbie, Jennifer, Schachar, Russell, Kelley, Elizabeth, Jones, Jessica, Arnold, Paul D., Courchesne, Eric, Pierce, Karen, Eyler, Lisa T., Campbell, Kathleen, Barnes, Cynthia Carter, Seidlitz, Jakob, Alexander-Bloch, Aaron F., and Bethlehem, Richard A.I.

Published
2024
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11. Development of white matter fiber covariance networks supports executive function in youth

Author

Bagautdinova, Joëlle, Bourque, Josiane, Sydnor, Valerie J., Cieslak, Matthew, Alexander-Bloch, Aaron F., Bertolero, Maxwell A., Cook, Philip A., Gur, Raquel E., Gur, Ruben C., Hu, Fengling, Larsen, Bart, Moore, Tyler M., Radhakrishnan, Hamsanandini, Roalf, David R., Shinohara, Russel T., Tapera, Tinashe M., Zhao, Chenying, Sotiras, Aristeidis, Davatzikos, Christos, and Satterthwaite, Theodore D.

Published
2023
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12. The molecular genetic landscape of human brain size variation

Author

Seidlitz, Jakob, Mallard, Travis T., Vogel, Jacob W., Lee, Younga H., Warrier, Varun, Ball, Gareth, Hansson, Oskar, Hernandez, Leanna M., Mandal, Ayan S., Wagstyl, Konrad, Lombardo, Michael V., Courchesne, Eric, Glessner, Joseph T., Satterthwaite, Theodore D., Bethlehem, Richard A.I., Bernstock, Joshua D., Tasaki, Shinya, Ng, Bernard, Gaiteri, Chris, Smoller, Jordan W., Ge, Tian, Gur, Raquel E., Gandal, Michael J., and Alexander-Bloch, Aaron F.

Published
2023
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16. Altered Sex Chromosome Dosage Induces Coordinated Shifts in Cortical Anatomy and Anatomical Covariance

Author

Xenophontos, Anastasia, Seidlitz, Jakob, Liu, Siyuan, Clasen, Liv S, Blumenthal, Jonathan D, Giedd, Jay N, Alexander-Bloch, Aaron, and Raznahan, Armin

Subjects
Mental Health, Biomedical Imaging, Clinical Research, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Adolescent, Adult, Cerebral Cortex, Child, Child, Preschool, Cross-Sectional Studies, Female, Gene Dosage, Humans, Magnetic Resonance Imaging, Male, Sex Chromosomes, Young Adult, anatomical coupling, aneuploidy, development, Klinefelter's, structural magnetic resonance imaging, Klinefelter’s, Psychology, Cognitive Sciences, Experimental Psychology
Abstract

Sex chromosome dosage (SCD) variation increases risk for neuropsychiatric impairment, which may reflect direct SCD effects on brain organization. Here, we 1) map cumulative X- and Y-chromosome dosage effects on regional cortical thickness (CT) and investigate potential functional implications of these effects using Neurosynth, 2) test if this map is organized by patterns of CT covariance that are evident in health, and 3) characterize SCD effects on CT covariance itself. We modeled SCD effects on CT and CT covariance for 308 equally sized regions of the cortical sheet using structural neuroimaging data from 301 individuals with varying numbers of sex chromosomes (169 euploid, 132 aneuploid). Mounting SCD increased CT in the rostral frontal cortex and decreased CT in the lateral temporal cortex, bilaterally. Regions targeted by SCD were associated with social functioning, language processing, and comprehension. Cortical regions with a similar degree of SCD-sensitivity showed heightened CT covariance in health. Finally, greater SCD also increased covariance among regions similarly affected by SCD. Our study both 1) develops novel methods for comparing typical and disease-related structural covariance networks in the brain and 2) uses these techniques to resolve and identify organizing principles for SCD effects on regional cortical anatomy and anatomical covariance.

Published
2020

20. Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain

Author

Vogel, Jacob W., primary, Alexander-Bloch, Aaron F., additional, Wagstyl, Konrad, additional, Bertolero, Maxwell A., additional, Markello, Ross D., additional, Pines, Adam, additional, Sydnor, Valerie J., additional, Diaz-Papkovich, Alex, additional, Hansen, Justine Y., additional, Evans, Alan C., additional, Bernhardt, Boris, additional, Misic, Bratislav, additional, Satterthwaite, Theodore D., additional, and Seidlitz, Jakob, additional

Published
2024
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21. Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth

Author

Cui, Zaixu, Pines, Adam R., Larsen, Bart, Sydnor, Valerie J., Li, Hongming, Adebimpe, Azeez, Alexander-Bloch, Aaron F., Bassett, Dani S., Bertolero, Max, Calkins, Monica E., Davatzikos, Christos, Fair, Damien A., Gur, Ruben C., Gur, Raquel E., Moore, Tyler M., Shanmugan, Sheila, Shinohara, Russell T., Vogel, Jacob W., Xia, Cedric H., Fan, Yong, and Satterthwaite, Theodore D.

Published
2022
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23. Rising Serum Uric Acid Level Is Negatively Associated with Survival in Renal Cell Carcinoma

Author

Yim, Kendrick, Bindayi, Ahmet, McKay, Rana, Mehrazin, Reza, Raheem, Omer A, Field, Charles, Bloch, Aaron, Wake, Robert, Ryan, Stephen, Patterson, Anthony, and Derweesh, Ithaar H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Clinical Research, Good Health and Well Being, chronic kidney disease, nephrectomy, overall survival, recurrence free survival, renal cell carcinoma, statins, uric acid, Oncology and Carcinogenesis, Oncology and carcinogenesis
Abstract

Aim and Background: To investigate the association of serum uric acid (SUA) levels along with statin use in Renal Cell Carcinoma (RCC), as statins may be associated with improved outcomes in RCC and SUA elevation is associated with increased risk of chronic kidney disease (CKD). Methods: Retrospective study of patients undergoing surgery for RCC with preoperative/postoperative SUA levels between 8/2005-8/2018. Analysis was carried out between patients with increased postoperative SUA vs. patients with decreased/stable postoperative SUA. Kaplan-Meier analysis (KMA) calculated overall survival (OS) and recurrence free survival (RFS). Multivariable analysis (MVA) was performed to identify factors associated with increased SUA levels and all-cause mortality. The prognostic significance of variables for OS and RFS was analyzed by cox regression analysis. Results: Decreased/stable SUA levels were noted in 675 (74.6%) and increased SUA levels were noted in 230 (25.4%). A higher proportion of patients with decreased/stable SUA levels took statins (27.9% vs. 18.3%, p = 0.0039). KMA demonstrated improved 5- and 10-year OS (89% vs. 47% and 65% vs. 9%, p < 0.001) and RFS (94% vs. 45% and 93% vs. 34%, p < 0.001), favoring patients with decreased/stable SUA levels. MVA revealed that statin use (Odds ratio (OR) 0.106, p < 0.001), dyslipidemia (OR 2.661, p = 0.004), stage III and IV disease compared to stage I (OR 1.887, p = 0.015 and 10.779, p < 0.001, respectively), and postoperative de novo CKD stage III (OR 5.952, p < 0.001) were predictors for increased postoperative SUA levels. MVA for all-cause mortality showed that increasing BMI (OR 1.085, p = 0.002), increasing ASA score (OR 1.578, p = 0.014), increased SUA levels (OR 4.698, p < 0.001), stage IV disease compared to stage I (OR 7.702, p < 0.001), radical nephrectomy (RN) compared to partial nephrectomy (PN) (OR 1.620, p = 0.019), and de novo CKD stage III (OR 7.068, p < 0.001) were significant factors. Cox proportional hazard analysis for OS revealed that increasing age (HR 1.017, p = 0.004), increasing BMI (Hazard Ratio (HR) 1.099, p < 0.001), increasing SUA (HR 4.708, p < 0.001), stage III and IV compared to stage I (HR 1.537, p = 0.013 and 3.299, p < 0.001), RN vs. PN (HR 1.497, p = 0.029), and de novo CKD stage III (HR 1.684, p < 0.001) were significant factors. Cox proportional hazard analysis for RFS demonstrated that increasing ASA score (HR 1.239, p < 0.001, increasing SUA (HR 9.782, p < 0.001), and stage II, III, and IV disease compared to stage I (HR 2.497, p < 0.001 and 3.195, p < 0.001 and 6.911, p < 0.001) were significant factors. Conclusions: Increasing SUA was associated with poorer outcomes. Decreased SUA levels were associated with statin intake and lower stage disease as well as lack of progression to CKD and anemia. Further investigation is requisite.

Published
2019

24. Curation of BIDS (CuBIDS): A workflow and software package for streamlining reproducible curation of large BIDS datasets

Author

Covitz, Sydney, Tapera, Tinashe M., Adebimpe, Azeez, Alexander-Bloch, Aaron F., Bertolero, Maxwell A., Feczko, Eric, Franco, Alexandre R., Gur, Raquel E., Gur, Ruben C., Hendrickson, Timothy, Houghton, Audrey, Mehta, Kahini, Murtha, Kristin, Perrone, Anders J., Robert-Fitzgerald, Tim, Schabdach, Jenna M., Shinohara, Russell T, Vogel, Jacob W., Zhao, Chenying, Fair, Damien A., Milham, Michael P., Cieslak, Matthew, and Satterthwaite, Theodore D.

Published
2022
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26. Dissociable multi-scale patterns of development in personalized brain networks

Author

Pines, Adam R., Larsen, Bart, Cui, Zaixu, Sydnor, Valerie J., Bertolero, Maxwell A., Adebimpe, Azeez, Alexander-Bloch, Aaron F., Davatzikos, Christos, Fair, Damien A., Gur, Ruben C., Gur, Raquel E., Li, Hongming, Milham, Michael P., Moore, Tyler M., Murtha, Kristin, Parkes, Linden, Thompson-Schill, Sharon L., Shanmugan, Sheila, Shinohara, Russell T., Weinstein, Sarah M., Bassett, Danielle S., Fan, Yong, and Satterthwaite, Theodore D.

Published
2022
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27. Sex-chromosome dosage effects on gene expression in humans

Author

Raznahan, Armin, Parikshak, Neelroop N, Chandran, Vijay, Blumenthal, Jonathan D, Clasen, Liv S, Alexander-Bloch, Aaron F, Zinn, Andrew R, Wangsa, Danny, Wise, Jasen, Murphy, Declan GM, Bolton, Patrick F, Ried, Thomas, Ross, Judith, Giedd, Jay N, and Geschwind, Daniel H

Subjects
Clinical Research, Biotechnology, Genetics, Rare Diseases, Human Genome, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Aneuploidy, Animals, Chromosomes, Human, X, Chromosomes, Human, Y, Female, Gene Dosage, Gene Expression Regulation, Genome-Wide Association Study, Humans, Kruppel-Like Transcription Factors, Male, Mice, Mice, Knockout, Models, Genetic, sex chromosomes, X-inactivation, sex differences, Turner syndrome, Klinefelter syndrome
Abstract

A fundamental question in the biology of sex differences has eluded direct study in humans: How does sex-chromosome dosage (SCD) shape genome function? To address this, we developed a systematic map of SCD effects on gene function by analyzing genome-wide expression data in humans with diverse sex-chromosome aneuploidies (XO, XXX, XXY, XYY, and XXYY). For sex chromosomes, we demonstrate a pattern of obligate dosage sensitivity among evolutionarily preserved X-Y homologs and update prevailing theoretical models for SCD compensation by detecting X-linked genes that increase expression with decreasing X- and/or Y-chromosome dosage. We further show that SCD-sensitive sex-chromosome genes regulate specific coexpression networks of SCD-sensitive autosomal genes with critical cellular functions and a demonstrable potential to mediate previously documented SCD effects on disease. These gene coexpression results converge with analysis of transcription factor binding site enrichment and measures of gene expression in murine knockout models to spotlight the dosage-sensitive X-linked transcription factor ZFX as a key mediator of SCD effects on wider genome expression. Our findings characterize the effects of SCD broadly across the genome, with potential implications for human phenotypic variation.

Published
2018

28. Normative brain size variation and brain shape diversity in humans

Author

Reardon, PK, Seidlitz, Jakob, Vandekar, Simon, Liu, Siyuan, Patel, Raihaan, Park, Min Tae M, Alexander-Bloch, Aaron, Clasen, Liv S, Blumenthal, Jonathan D, Lalonde, Francois M, Giedd, Jay N, Gur, Ruben C, Gur, Raquel E, Lerch, Jason P, Chakravarty, M Mallar, Satterthwaite, Theodore D, Shinohara, Russell T, and Raznahan, Armin

Subjects
Biological Psychology, History, Heritage and Archaeology, Human Society, Archaeology, Anthropology, Psychology, Pediatric, Neurosciences, 1.1 Normal biological development and functioning, Underpinning research, Neurological, Biological Evolution, Brain, Humans, Neuroimaging, Organ Size, General Science & Technology
Abstract

Brain size variation over primate evolution and human development is associated with shifts in the proportions of different brain regions. Individual brain size can vary almost twofold among typically developing humans, but the consequences of this for brain organization remain poorly understood. Using in vivo neuroimaging data from more than 3000 individuals, we find that larger human brains show greater areal expansion in distributed frontoparietal cortical networks and related subcortical regions than in limbic, sensory, and motor systems. This areal redistribution recapitulates cortical remodeling across evolution, manifests by early childhood in humans, and is linked to multiple markers of heightened metabolic cost and neuronal connectivity. Thus, human brain shape is systematically coupled to naturally occurring variations in brain size through a scaling map that integrates spatiotemporally diverse aspects of neurobiology.

Published
2018

29. Searching for Imaging Biomarkers of Psychotic Dysconnectivity

Author

Rodrigue, Amanda L., Mastrovito, Dana, Esteban, Oscar, Durnez, Joke, Koenis, Marinka M.G., Janssen, Ronald, Alexander-Bloch, Aaron, Knowles, Emma M., Mathias, Samuel R., Mollon, Josephine, Pearlson, Godfrey D., Frangou, Sophia, Blangero, John, Poldrack, Russell A., and Glahn, David C.

Published
2021
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31. Atypical brain aging and its association with working memory performance in major depressive disorder

Author

Ho, Natalie C.W., primary, Bethlehem, Richard AI., additional, Seidlitz, Jakob, additional, Nogovitsyn, Nikita, additional, Metzak, Paul, additional, Ballester, Pedro L., additional, Hassel, Stefanie, additional, Rotzinger, Susan, additional, Poppenk, Jordan, additional, Lam, Raymond W., additional, Taylor, Valerie H., additional, Milev, Roumen, additional, Adamson, Chris, additional, Adler, Sophie, additional, Alexander-Bloch, Aaron F., additional, Anagnostou, Evdokia, additional, Anderson, Kevin M., additional, Areces-Gonzalez, Ariosky, additional, Astle, Duncan E., additional, Auyeung, Bonnie, additional, Ayub, Muhammad, additional, Bae, Jong Bin, additional, Ball, Gareth, additional, Baron-Cohen, Simon, additional, Beare, Richard, additional, Bedford, Saashi A., additional, Benegal, Vivek, additional, Bethlehem, Richard A.I., additional, Beyer, Frauke, additional, Blangero, John, additional, Blesa Cábez, Manuel, additional, Boardman, James P., additional, Borzage, Matthew, additional, Bosch-Bayard, Jorge F., additional, Bourke, Niall, additional, Bullmore, Edward T., additional, Calhoun, Vince D., additional, Chakravarty, Mallar M., additional, Chen, Christina, additional, Chertavian, Casey, additional, Chetelat, Gaël, additional, Chong, Yap S., additional, Corvin, Aiden, additional, Costantino, Manuela, additional, Courchesne, Eric, additional, Crivello, Fabrice, additional, Cropley, Vanessa L., additional, Crosbie, Jennifer, additional, Crossley, Nicolas, additional, Delarue, Marion, additional, Delorme, Richard, additional, Desrivieres, Sylvane, additional, Devenyi, Gabriel, additional, Di Biase, Maria A., additional, Dolan, Ray, additional, Donald, Kirsten A., additional, Donohoe, Gary, additional, Dorfschmidt, Lena, additional, Dunlop, Katharine, additional, Edwards, Anthony D., additional, Elison, Jed T., additional, Ellis, Cameron T., additional, Elman, Jeremy A., additional, Eyler, Lisa, additional, Fair, Damien A., additional, Fletcher, Paul C., additional, Fonagy, Peter, additional, Franz, Carol E., additional, Galan-Garcia, Lidice, additional, Gholipour, Ali, additional, Giedd, Jay, additional, Gilmore, John H., additional, Glahn, David C., additional, Goodyer, Ian M., additional, Grant, P.E., additional, Groenewold, Nynke A., additional, Gudapati, Shreya, additional, Gunning, Faith M., additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Hammill, Christopher F., additional, Hansson, Oskar, additional, Hedden, Trey, additional, Heinz, Andreas, additional, Henson, Richard N., additional, Heuer, Katja, additional, Hoare, Jacqueline, additional, Holla, Bharath, additional, Holmes, Avram J., additional, Huang, Hao, additional, Ipser, Jonathan, additional, Jack, Clifford R., additional, Jackowski, Andrea P., additional, Jia, Tianye, additional, Jones, David T., additional, Jones, Peter B., additional, Kahn, Rene S., additional, Karlsson, Hasse, additional, Karlsson, Linnea, additional, Kawashima, Ryuta, additional, Kelley, Elizabeth A., additional, Kern, Silke, additional, Kim, Ki-Woong, additional, Kitzbichler, Manfred G., additional, Kremen, William S., additional, Lalonde, François, additional, Landeau, Brigitte, additional, Lerch, Jason, additional, Lewis, John D., additional, Li, Jiao, additional, Liao, Wei, additional, Liston, Conor, additional, Lombardo, Michael V., additional, Lv, Jinglei, additional, Mallard, Travis T., additional, Marcelis, Machteld, additional, Mathias, Samuel R., additional, Mazoyer, Bernard, additional, McGuire, Philip, additional, Meaney, Michael J., additional, Mechelli, Andrea, additional, Misic, Bratislav, additional, Morgan, Sarah E., additional, Mothersill, David, additional, Ortinau, Cynthia, additional, Ossenkoppele, Rik, additional, Ouyang, Minhui, additional, Palaniyappan, Lena, additional, Paly, Leo, additional, Pan, Pedro M., additional, Pantelis, Christos, additional, Park, Min Tae M., additional, Paus, Tomas, additional, Pausova, Zdenka, additional, Paz-Linares, Deirel, additional, Pichet Binette, Alexa, additional, Pierce, Karen, additional, Qian, Xing, additional, Qiu, Anqi, additional, Raznahan, Armin, additional, Rittman, Timothy, additional, Rodrigue, Amanda, additional, Rollins, Caitlin K., additional, Romero-Garcia, Rafael, additional, Ronan, Lisa, additional, Rosenberg, Monica D., additional, Rowitch, David H., additional, Salum, Giovanni A., additional, Satterthwaite, Theodore D., additional, Schaare, H. Lina, additional, Schabdach, Jenna, additional, Schachar, Russell J., additional, Schöll, Michael, additional, Schultz, Aaron P., additional, Sharp, David, additional, Shinohara, Russell T., additional, Skoog, Ingmar, additional, Smyser, Christopher D., additional, Sperling, Reisa A., additional, Stein, Dan J., additional, Stolicyn, Aleks, additional, Suckling, John, additional, Sullivan, Gemma, additional, Thyreau, Benjamin, additional, Toro, Roberto, additional, Traut, Nicolas, additional, Tsvetanov, Kamen A., additional, Turk-Browne, Nicholas B., additional, Tuulari, Jetro J., additional, Tzourio, Christophe, additional, Vachon-Presseau, Étienne, additional, Valdes-Sosa, Mitchell J., additional, Valdes-Sosa, Pedro A., additional, Valk, Sofie L., additional, van Amelsvoort, Therese, additional, Vandekar, Simon N., additional, Vasung, Lana, additional, Vértes, Petra E., additional, Victoria, Lindsay W., additional, Villeneuve, Sylvia, additional, Villringer, Arno, additional, Vogel, Jacob W., additional, Wagstyl, Konrad, additional, Wang, Yin-Shan S., additional, Warfield, Simon K., additional, Warrier, Varun, additional, Westman, Eric, additional, Westwater, Margaret L., additional, Whalley, Heather C., additional, White, Simon R., additional, Witte, A. Veronica, additional, Yang, Ning, additional, Yeo, B.T. Thomas, additional, Yun, Hyuk Jin, additional, Zalesky, Andrew, additional, Zar, Heather J., additional, Zettergren, Anna, additional, Zhou, Juan H., additional, Ziauddeen, Hisham, additional, Zimmerman, Dabriel, additional, Zugman, Andre, additional, Zuo, Xi-Nian N., additional, Frey, Benicio N., additional, Harkness, Kate L., additional, Addington, Jean, additional, and Kennedy, Sidney H., additional

Published
2024
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33. Imaging local genetic influences on cortical folding

Author

Alexander-Bloch, Aaron F., Raznahan, Armin, Vandekar, Simon N., Seidlitz, Jakob, Lu, Zhixin, Mathias, Samuel R., Knowles, Emma, Mollon, Josephine, Rodrigue, Amanda, Curran, Joanne E., Görring, Harald H. H., Satterthwaite, Theodore D., Gur, Raquel E., Bassett, Danielle S., Hoftman, Gil D., Pearlson, Godfrey, Shinohara, Russell T., Liu, Siyuan, Fox, Peter T., Almasy, Laura, Blangero, John, and Glahn, David C.

Published
2020

34. Development of structure–function coupling in human brain networks during youth

Author

Baum, Graham L., Cui, Zaixu, Roalf, David R., Ciric, Rastko, Betzel, Richard F., Larsen, Bart, Cieslak, Matthew, Cook, Philip A., Xia, Cedric H., Moore, Tyler M., Ruparel, Kosha, Oathes, Desmond J., Alexander-Bloch, Aaron F., Shinohara, Russell T., Raznahan, Armin, Gur, Raquel E., Gur, Ruben C., Bassett, Danielle S., and Satterthwaite, Theodore D.

Published
2020

35. Human adolescent brain similarity development is different for paralimbic versus neocortical zones.

Author

Dorfschmidt, Lena, Váša, František, White, Simon R., Romero-García, Rafael, Kitzbichler, Manfred G., Alexander-Bloch, Aaron, Cieslak, Matthew, Mehta, Kahini, Satterthwaite, Theodore D., Bethlehem, Richard A. I., Seidlitz, Jakob, Vértes, Petra E., and Bullmore, Edward T.

Subjects
MAGNETIC resonance imaging, FUNCTIONAL magnetic resonance imaging, ADOLESCENT development, CEREBRAL cortical thinning, CINGULATE cortex
Abstract

Adolescent development of human brain structural and functional networks is increasingly recognized as fundamental to emergence of typical and atypical adult cognitive and emotional processes. We analysed multimodal magnetic resonance imaging (MRI) data collected from N ~ 300 healthy adolescents (51%; female; 14 to 26 y) each scanned repeatedly in an accelerated longitudinal design, to provide an analyzable dataset of 469 structural scans and 448 functional MRI scans. We estimated the morphometric similarity between each possible pair of 358 cortical areas on a feature vector comprising six macro- and microstructural MRI metrics, resulting in a morphometric similarity network (MSN) for each scan. Over the course of adolescence, we found that morphometric similarity increased in paralimbic cortical areas, e.g., insula and cingulate cortex, but generally decreased in neocortical areas, and these results were replicated in an independent developmental MRI cohort (N~304). Increasing hubness of paralimbic nodes in MSNs was associated with increased strength of coupling between their morphometric similarity and functional connectivity. Decreasing hubness of neocortical nodes in MSNs was associated with reduced strength of structure-function coupling and increasingly diverse functional connections in the corresponding fMRI networks. Neocortical areas became more structurally differentiated and more functionally integrative in a metabolically expensive process linked to cortical thinning and myelination, whereas paralimbic areas specialized for affective and interoceptive functions became less differentiated, as hypothetically predicted by a developmental transition from periallocortical to proisocortical organization of the cortex. Cytoarchitectonically distinct zones of the human cortex undergo distinct neurodevelopmental programs during typical adolescence. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Network enrichment significance testing in brain–phenotype association studies.

Author

Weinstein, Sarah M., Vandekar, Simon N., Li, Bin, Alexander‐Bloch, Aaron F., Raznahan, Armin, Li, Mingyao, Gur, Raquel E., Gur, Ruben C., Roalf, David R., Park, Min Tae M., Chakravarty, Mallar, Baller, Erica B., Linn, Kristin A., Satterthwaite, Theodore D., and Shinohara, Russell T.

Subjects
STATISTICAL hypothesis testing, BRAIN imaging, PHENOTYPES, LARGE-scale brain networks, GENETICS
Abstract

Functional networks often guide our interpretation of spatial maps of brain–phenotype associations. However, methods for assessing enrichment of associations within networks of interest have varied in terms of both scientific rigor and underlying assumptions. While some approaches have relied on subjective interpretations, others have made unrealistic assumptions about spatial properties of imaging data, leading to inflated false positive rates. We seek to address this gap in existing methodology by borrowing insight from a method widely used in genetics research for testing enrichment of associations between a set of genes and a phenotype of interest. We propose network enrichment significance testing (NEST), a flexible framework for testing the specificity of brain–phenotype associations to functional networks or other sub‐regions of the brain. We apply NEST to study enrichment of associations with structural and functional brain imaging data from a large‐scale neurodevelopmental cohort study. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer’s disease: diagnosis, longitudinal progress and biological basis

Author

Zhao, Kun, Ding, Yanhui, Han, Ying, Fan, Yong, Alexander-Bloch, Aaron F., Han, Tong, Jin, Dan, Liu, Bing, Lu, Jie, Song, Chengyuan, Wang, Pan, Wang, Dawei, Wang, Qing, Xu, Kaibin, Yang, Hongwei, Yao, Hongxiang, Zheng, Yuanjie, Yu, Chunshui, Zhou, Bo, Zhang, Xinqing, Zhou, Yuying, Jiang, Tianzi, Zhang, Xi, and Liu, Yong

Published
2020
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38. Molecular signatures of cortical expansion in the human fetal brain

Author

Ball, Gareth, primary, Oldham, Stuart, additional, Kyriakopoulou, Vanessa, additional, Williams, Logan Zane John, additional, Karolis, Vyacheslav R, additional, Price, Anthony, additional, Hutter, Jana, additional, Seal, Marc L, additional, Alexander-Bloch, Aaron, additional, Hajnal, Joseph V, additional, Edwards, A. David, additional, Robinson, Emma Claire, additional, and Seidlitz, Jakob, additional

Published
2024
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39. Transcriptional cartography integrates multiscale biology of the human cortex

Author

Wagstyl, Konrad, primary, Adler, Sophie, additional, Seidlitz, Jakob, additional, Vandekar, Simon, additional, Mallard, Travis T, additional, Dear, Richard, additional, DeCasien, Alex R, additional, Satterthwaite, Theodore D, additional, Liu, Siyuan, additional, Vértes, Petra E, additional, Shinohara, Russell T, additional, Alexander-Bloch, Aaron, additional, Geschwind, Daniel H, additional, and Raznahan, Armin, additional

Published
2024
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40. Author Response: Transcriptional cartography integrates multiscale biology of the human cortex

Author

Wagstyl, Konrad, primary, Adler, Sophie, additional, Seidlitz, Jakob, additional, Vandekar, Simon, additional, Mallard, Travis T, additional, Dear, Richard, additional, DeCasien, Alex R, additional, Satterthwaite, Theodore D, additional, Liu, Siyuan, additional, Vértes, Petra E, additional, Shinohara, Russell T, additional, Alexander-Bloch, Aaron, additional, Geschwind, Daniel H, additional, and Raznahan, Armin, additional

Published
2024
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41. Subtle in‐scanner motion biases automated measurement of brain anatomy from in vivo MRI

Author

Alexander-Bloch, Aaron, Clasen, Liv, Stockman, Michael, Ronan, Lisa, Lalonde, Francois, Giedd, Jay, and Raznahan, Armin

Subjects
Neurosciences, Pediatric, Brain Disorders, Biomedical Imaging, Clinical Research, Bioengineering, Neurological, Adolescent, Adult, Artifacts, Brain, Child, Child, Preschool, Female, Gray Matter, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motion, Organ Size, Pattern Recognition, Automated, Young Adult, functional neuroimaging, magnetic resonance imaging, motion, bias, cortical thickness, cortical surface area, cortical curvature, Cognitive Sciences, Experimental Psychology
Abstract

While the potential for small amounts of motion in functional magnetic resonance imaging (fMRI) scans to bias the results of functional neuroimaging studies is well appreciated, the impact of in-scanner motion on morphological analysis of structural MRI is relatively under-studied. Even among "good quality" structural scans, there may be systematic effects of motion on measures of brain morphometry. In the present study, the subjects' tendency to move during fMRI scans, acquired in the same scanning sessions as their structural scans, yielded a reliable, continuous estimate of in-scanner motion. Using this approach within a sample of 127 children, adolescents, and young adults, significant relationships were found between this measure and estimates of cortical gray matter volume and mean curvature, as well as trend-level relationships with cortical thickness. Specifically, cortical volume and thickness decreased with greater motion, and mean curvature increased. These effects of subtle motion were anatomically heterogeneous, were present across different automated imaging pipelines, showed convergent validity with effects of frank motion assessed in a separate sample of 274 scans, and could be demonstrated in both pediatric and adult populations. Thus, using different motion assays in two large non-overlapping sets of structural MRI scans, convergent evidence showed that in-scanner motion-even at levels which do not manifest in visible motion artifact-can lead to systematic and regionally specific biases in anatomical estimation. These findings have special relevance to structural neuroimaging in developmental and clinical datasets, and inform ongoing efforts to optimize neuroanatomical analysis of existing and future structural MRI datasets in non-sedated humans. Hum Brain Mapp 37:2385-2397, 2016. © 2016 Wiley Periodicals, Inc.

Published
2016

42. Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology

Author

Bedford, Saashi A., primary, Lai, Meng-Chuan, additional, Lombardo, Michael V, additional, Chakrabarti, Bhismadev, additional, Ruigrok, Amber, additional, Suckling, John, additional, Anagnostou, Evdokia, additional, Lerch, Jason P, additional, Taylor, Margot, additional, Nicolson, Rob, additional, Stelios, Georgiades, additional, Crosbie, Jennifer, additional, Schachar, Russell, additional, Kelley, Elizabeth, additional, Jones, Jessica, additional, Arnold, Paul D, additional, Courchesne, Eric, additional, Pierce, Karen, additional, Eyler, Lisa T, additional, Campbell, Kathleen, additional, Carter Barnes, Cynthia, additional, Seidlitz, Jakob, additional, Alexander-Bloch, Aaron F, additional, Bullmore, Edward T, additional, Baron-Cohen, Simon, additional, and Bethlehem, Richard AI, additional

Published
2023
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43. BrainChart cortical thickness centile scores: a generalizable tool to detect age‐inappropriate cortical neurodegeneration in Alzheimer’s disease

Author

Parker, Thomas D, primary, Bethlehem, Richard A.I., additional, Seidlitz, Jakob, additional, White, Simon R, additional, Bernstock, Joshua D, additional, Bourke, Niall, additional, David, Michael CB, additional, de Taurines, Anastasia Francoise L Gailly, additional, Giovane, Martina Del, additional, Graham, Neil SN, additional, Kolanko, Magdalena A, additional, Zimmerman, Karl A, additional, Malhotra, Paresh A, additional, Patel, Maneesh, additional, Scott, Gregory PT, additional, Alexander‐Bloch, Aaron, additional, Bullmore, Edward T, additional, and Sharp, David J, additional

Published
2023
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44. Effects of Alzheimer’s disease genetic risk on brain morphometric development in three multiple‐ancestry pediatric datasets

Author

Vogel, Jacob W, primary, Schultz, Laura M, additional, Larsen, Bart, additional, Seidlitz, Jakob, additional, Al‐Sharif, Noor B, additional, Barzilay, Ran, additional, Cieslak, Matthew, additional, Covitz, Sydney, additional, Gur, Raquel E, additional, Gur, Ruben C, additional, Huguet, Guillaume, additional, La Joie, Renaud, additional, McMillan, Corey T, additional, Nilsson, Nathalie I.V., additional, Poline, Jean‐Baptiste, additional, Ruparel, Kosha, additional, Shinohara, Russell T., additional, Wisse, Laura EM, additional, Wolf, Daniel, additional, Wolk, David A., additional, Alexander‐Bloch, Aaron, additional, Almasy, Laura, additional, and Satterthwaite, Theodore, additional

Published
2023
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45. Child Psychiatry Branch of the National Institute of Mental Health Longitudinal Structural Magnetic Resonance Imaging Study of Human Brain Development

Author

Giedd, Jay N, Raznahan, Armin, Alexander-Bloch, Aaron, Schmitt, Eric, Gogtay, Nitin, and Rapoport, Judith L

Subjects
Biological Psychology, Clinical and Health Psychology, Psychology, Attention Deficit Hyperactivity Disorder (ADHD), Behavioral and Social Science, Pediatric, Neurosciences, Mental Health, Biomedical Imaging, Brain Disorders, Clinical Research, Neurological, Mental health, Good Health and Well Being, Brain, Child, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Mental Disorders, National Institute of Mental Health (U.S.), United States, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biological psychology
Abstract

The advent of magnetic resonance imaging, which safely allows in vivo quantification of anatomical and physiological features of the brain, has revolutionized pediatric neuroscience. Longitudinal studies are useful for the characterization of developmental trajectories (ie, changes in imaging measures by age). Developmental trajectories (as opposed to static measures) have proven to have greater power in discriminating healthy from clinical groups and in predicting cognitive/behavioral measures, such as IQ. Here we summarize results from an ongoing longitudinal pediatric neuroimaging study that has been conducted at the Child Psychiatry Branch of the National Institute of Mental Health since 1989. Developmental trajectories of structural MRI brain measures from healthy youth are compared and contrasted with trajectories in attention-deficit/hyperactivity disorder (ADHD) and childhood-onset schizophrenia. Across ages 5-25 years, in both healthy and clinical populations, white matter volumes increase and gray matter volumes follow an inverted U trajectory, with peak size occurring at different times in different regions. At a group level, differences related to psychopathology are seen for gray and white matter volumes, rates of change, and for interconnectedness among disparate brain regions.

Published
2015

48. Network Enrichment Significance Testing in Brain-Phenotype Association Studies

Author

Weinstein, Sarah M, primary, Vandekar, Simon N, additional, Alexander-Bloch, Aaron F, additional, Raznahan, Armin, additional, Li, Mingyao, additional, Gur, Raquel E, additional, Gur, Ruben C, additional, Roalf, David R, additional, Park, Min Tae M, additional, Chakravarty, Mallar, additional, Baller, Erica B, additional, Linn, Kristin A, additional, Satterthwaite, Theodore D, additional, and Shinohara, Russell T, additional

Published
2023
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49. The overlapping genetic architecture of psychiatric disorders and cortical brain structure

Author

Sha, Zhiqiang, primary, Warrier, Varun, additional, Bethlehem, Richard A.I., additional, Schultz, Laura M., additional, Merikangas, Alison, additional, Sun, Kevin Y., additional, Gur, Ruben C., additional, Gur, Raquel E., additional, Shinohara, Russell T., additional, Seidlitz, Jakob, additional, Almasy, Laura, additional, Andreassen, Ole A., additional, and Alexander-Bloch, Aaron F., additional

Published
2023
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