1. Glycophorin as a possible receptor for Plasmodium falciparum.
- Author
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Pasvol G, Jungery M, Weatherall DJ, Parsons SF, Anstee DJ, and Tanner MJ
- Subjects
- Blood Group Antigens drug effects, Erythrocyte Membrane metabolism, Humans, Models, Biological, Plasmodium falciparum drug effects, Trypsin pharmacology, Erythrocyte Membrane parasitology, Erythrocytes parasitology, Glycophorins physiology, Plasmodium falciparum metabolism, Receptors, Immunologic immunology, Sialoglycoproteins physiology
- Abstract
Human red cells deficient in glycophorin B are partly resistant to invasion by Plasmodium falciparum and become completely resistant when glycophorin A is removed from their surface by trypsin treatment. Similar treatment of cells which have a hybrid glycophorin molecule renders them glycophorin-deficient and resistant to invasion. Tn and Wrb -ve cells with defined alterations in glycophorin A or B are also resistant to invasion. These findings suggest that both glycophorins A and B are involved in parasite invasion, indicate which parts of these molecules may be involved in this process, and provide the basis for a tentative model of parasite/red-cell interactions.
- Published
- 1982
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