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4 results on '"Blunsum, Andrew E."'

1. Seoul Virus Associated with Pet Rats, Scotland, UK, 2019

Author

Shepherd, James G., Blunsum, Andrew E., Carmichael, Stephen, Smollett, Katherine, Maxwell-Scott, Hector, Farmer, Eoghan C.W., Osborne, Jane, MacLean, Alasdair, Ashraf, Shinn, Shah, Rajiv, Gunson, Rory, Filipe, Ana da Silva, Aarons, Emma J., and Thomson, Emma C.

Subjects
Hantavirus infections -- Diagnosis -- Care and treatment -- Distribution, Rodents as pets -- Diseases -- Care and treatment, Company distribution practices, Health
Abstract

Hantaviruses (genus Orthohantavirus, family Hantaviridae) are segmented, single-stranded RNA viruses maintained by chronic subclinical infection of rodent and insectivore hosts. Human infection occurs after exposure to the saliva, urine, or [...]

Published
2021
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2. Widespread human exposure to ledanteviruses in Uganda - a population study

Author

Shepherd, James G, primary, Ashraf, Shirin, additional, Salazar-Gonzalez, Jesus F, additional, Salazar, Maria G, additional, Downing, Robert G, additional, Bukenya, Henry, additional, Jerome, Hanna, additional, Mpanga, Joseph T, additional, Davis, Chris, additional, Tong, Lily, additional, Vattipally, Sreenu, additional, Atiku, Linda A, additional, Logan, Nicola, additional, Kajik, Ezekiel, additional, Mukobi, Yafesi, additional, Mungujakisa, Cyrus, additional, Olowo, Michael V, additional, Tibo, Emmanuel, additional, Wunna, Fred, additional, Jackson Ireland, Hollie, additional, Blunsum, Andrew E, additional, Owolabi, Iyanuoluwani, additional, da Silva Filipe, Ana, additional, Bwogi, Josephine, additional, Willet, Brian, additional, Lutwama, Julius J, additional, Streicker, Daniel G, additional, Kaleebu, Pontiano, additional, and Thomson, Emma C, additional

Published
2023
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3. Evaluation of the Implementation of the 4C Mortality Score in United Kingdom hospitals during the second pandemic wave

Author

Blunsum, Andrew E., primary, Perkins, Jonathan S., additional, Arshad, Areeb, additional, Bajpai, Sukrit, additional, Barclay-Elliott, Karen, additional, Brito-Mutunayagam, Sanjita, additional, Brooks, Rebecca, additional, Chan, Terrence, additional, Coates, Dominic J. G., additional, Corobana, Alina, additional, Crocker-Buqué, Tim, additional, Evans, Terry J., additional, Gordon-Brown, Jasmine, additional, Hack, Berkin, additional, Hiles, Heather, additional, Khanijau, Aakash, additional, Lalwani, Salina, additional, Leong, Clare, additional, MacKay, Kirsty, additional, Macrae, Catriona, additional, Martin, Bryony, additional, Martin, Christopher A., additional, McKemey, Emily, additional, Nazareth, Joshua, additional, Pan, Daniel, additional, Scopazzini, Marcello, additional, Simons, David, additional, Swinhoe, Sophie, additional, Thomas, Julia, additional, Thorburn, Fiona, additional, Walpole, Sarah, additional, Warne, Esmie, additional, Wilson, Rory, additional, MacConnachie, Alisdair, additional, and Ho, Antonia, additional

Published
2021
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4. Widespread human exposure to ledanteviruses in Uganda: A population study.

Author

Shepherd JG, Ashraf S, Salazar-Gonzalez JF, Salazar MG, Downing RG, Bukenya H, Jerome H, Mpanga JT, Davis C, Tong L, Sreenu VB, Atiku LA, Logan N, Kajik E, Mukobi Y, Mungujakisa C, Olowo MV, Tibo E, Wunna F, Jackson Ireland H, Blunsum AE, Owolabi I, da Silva Filipe A, Bwogi J, Willett BJ, Lutwama JJ, Streicker DG, Kaleebu P, and Thomson EC

Subjects
Humans, Uganda epidemiology, Adult, Male, Female, Adolescent, Young Adult, Middle Aged, Child, Child, Preschool, Rhabdoviridae Infections epidemiology, Rhabdoviridae Infections virology, Rhabdoviridae Infections veterinary, Seroepidemiologic Studies, Animals, Cross Reactions, Infant, Aged, Phylogeny, Enzyme-Linked Immunosorbent Assay, Metagenomics, Antibodies, Viral blood, Rhabdoviridae isolation & purification, Rhabdoviridae genetics, Rhabdoviridae classification
Abstract

Le Dantec virus (LDV), assigned to the species Ledantevirus ledantec, genus Ledantevirus, family Rhabdoviridae has been associated with human disease but has gone undetected since the 1970s. We describe the detection of LDV in a human case of undifferentiated fever in Uganda by metagenomic sequencing and demonstrate a serological response using ELISA and pseudotype neutralisation. By screening 997 individuals sampled in 2016, we show frequent exposure to ledanteviruses with 76% of individuals seropositive in Western Uganda, but lower seroprevalence in other areas. Serological cross-reactivity as measured by pseudotype-based neutralisation was confined to ledanteviruses, indicating population seropositivity may represent either exposure to LDV or related ledanteviruses. We also describe the discovery of a closely related ledantevirus in blood from the synanthropic rodent Mastomys erythroleucus. Ledantevirus infection is common in Uganda but is geographically heterogenous. Further surveys of patients presenting with acute fever are required to determine the contribution of these emerging viruses to febrile illness in Uganda., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Shepherd et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Published
2024
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