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372 results on '"Blyth, E."'

1. EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity

Author

Gandhi, M.K., Hoang, T., Law, S.C., Brosda, S., O'Rourke, K., Tobin, J.W.D., Vari, F., Murigneux, V., Fink, L., Gunawardana, J., Gould, C., Oey, H., Bednarska, K., Delecluse, S., Trappe, R.U., Merida de Long, L., Sabdia, M.B., Bhagat, G., Hapgood, G., Blyth, E., Clancy, L., Wight, J., Hawkes, E., Rimsza, L.M., Maguire, A., Bojarczuk, K., Chapuy, B., and Keane, C.

Published
2021
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2. A framework for benchmarking land models

Author

Luo, Y. Q, Randerson, J. T, Abramowitz, G., Bacour, C., Blyth, E., Carvalhais, N., Ciais, P., Dalmonech, D., Fisher, J. B, Fisher, R., Friedlingstein, P., Hibbard, K., Hoffman, F., Huntzinger, D., Jones, C. D, Koven, C., Lawrence, D., Li, D. J, Mahecha, M., Niu, S. L, Norby, R., Piao, S. L, Qi, X., Peylin, P., Prentice, I. C, Riley, W., Reichstein, M., Schwalm, C., Wang, Y. P, Xia, J. Y, Zaehle, S., and Zhou, X. H

Subjects
atmosphere-biosphere interaction, benchmarking, biogeochemistry, biophysics, climate change, climate feedback, ecosystem modeling, ecosystem response, numerical model, prediction, spatiotemporal analysis, trace gas, vegetation dynamics
Abstract

Land models, which have been developed by the modeling community in the past few decades to predict future states of ecosystems and climate, have to be critically evaluated for their performance skills of simulating ecosystem responses and feedback to climate change. Benchmarking is an emerging procedure to measure performance of models against a set of defined standards. This paper proposes a benchmarking framework for evaluation of land model performances and, meanwhile, highlights major challenges at this infant stage of benchmark analysis. The framework includes (1) targeted aspects of model performance to be evaluated, (2) a set of benchmarks as defined references to test model performance, (3) metrics to measure and compare performance skills among models so as to identify model strengths and deficiencies, and (4) model improvement. Land models are required to simulate exchange of water, energy, carbon and sometimes other trace gases between the atmosphere and land surface, and should be evaluated for their simulations of biophysical processes, biogeochemical cycles, and vegetation dynamics in response to climate change across broad temporal and spatial scales. Thus, one major challenge is to select and define a limited number of benchmarks to effectively evaluate land model performance. The second challenge is to develop metrics of measuring mismatches between models and benchmarks. The metrics may include (1) a priori thresholds of acceptable model performance and (2) a scoring system to combine data–model mismatches for various processes at different temporal and spatial scales. The benchmark analyses should identify clues of weak model performance to guide future development, thus enabling improved predictions of future states of ecosystems and climate. The near-future research effort should be on development of a set of widely acceptable benchmarks that can be used to objectively, effectively, and reliably evaluate fundamental properties of land models to improve their prediction performance skills.

Published
2012

7. Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

Author

Bishop, DC, Clancy, LE, Simms, R, Burgess, J, Mathew, G, Moezzi, L, Street, JA, Sutrave, G, Atkins, E, McGuire, HM, Gloss, BS, Lee, K, Jiang, W, Maddock, K, McCaughan, G, Avdic, S, Antonenas, V, O'Brien, TA, Shaw, PJ, Irving, DO, Gottlieb, DJ, Blyth, E, and Micklethwaite, KP

Subjects
1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, Adult, Male, Lymphoma, B-Cell, Lymphoma, Immunology, Hematopoietic Stem Cell Transplantation, Receptors, Antigen, T-Cell, Middle Aged, Immunotherapy, Adoptive, Young Adult, Treatment Outcome, DNA Transposable Elements, Leukemia, B-Cell, Humans, Female, Aged
Published
2021

27. Allogeneic stem cell transplant (HSCT) for acute lymphoblastic leukaemia (ALL) using CD34 selected stem cells followed by prophylactic infusions of pathogen-specific and CD19 CAR T cells

Author

Blyth, E., primary, Jiang, W., additional, Clancy, L.E., additional, Sutrave, G., additional, Street, J., additional, Simms, R., additional, Avdic, S., additional, Atkins, E., additional, Antonenas, V., additional, Bishop, D.C., additional, Micklethwaite, K., additional, and Gottlieb, D., additional

Published
2020
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34. EBV+ CNS LYMPHOMAS HAVE A DISTINCTIVE TUMOR MICROENVIRONMENT AND GENETIC PROFILE, WHICH IS AMENABLE TO COMBINATION 3RD PARTY EBV-SPECIFIC CTL AND IBRUTINIB THERAPY

Author

Gandhi, M.K., primary, Hoang, T., additional, Tobin, J.W., additional, Law, S.C., additional, Talaulikar, D., additional, Jain, S., additional, Vari, F., additional, Murigneux, V., additional, Fink, L., additional, Gunawardana, J., additional, Gould, C., additional, Oey, H., additional, Delecluse, S., additional, Trappe, R.U., additional, Merida de Long, L., additional, Sabdia, M.B., additional, Bhagat, G., additional, Hapgood, G., additional, Blyth, E., additional, Clancy, L., additional, Casey, J., additional, Wight, J., additional, Hawkes, E., additional, and Keane, C., additional

Published
2019
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35. Matched sibling donor-derived piggybac CAR19 T cells induce remission of relapsed/refractory CD19+ malignancy following haematopoietic stem cell transplant

Author

Bishop, D.C., primary, Clancy, L.E., additional, Burgess, J., additional, Mathew, G., additional, Atkins, E., additional, Advic, S., additional, Maddock, K., additional, Street, J., additional, Moezzi, L., additional, Simms, R., additional, Stephen, K., additional, O'Brien, T., additional, Shaw, P.J., additional, Gottlieb, D., additional, Blyth, E., additional, and Micklethwaite, K., additional

Published
2019
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37. Uncertainties in simulated evapotranspiration from land surface models over a 14-year Mediterranean crop succession

Author

Garrigues, Sébastien, Verhoef, A., Vidale, P.L., Sarojini, B, Blyth, E., Olioso, Albert, Boone, A., Albergel, Clément, Decharme, B., Calvet, J.-C., Carrer, Dominique, Moulin, Sophie, Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Geography and Environmental Science, University of Reading (UOR), Department of Meteorology [Reading], Centre national de recherches météorologiques (CNRM), Météo France-Centre National de la Recherche Scientifique (CNRS), Météo France, Centre National de la Recherche Scientifique (CNRS), Centre for Ecology and Hydrology, Institut national des sciences de l'Univers (INSU - CNRS)-Météo France-Centre National de la Recherche Scientifique (CNRS), and Météo France-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Modèle de bilan énergétique, modèle de transfert hydrique, evapotranspiration, bilan hydraulique, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, plante méditerranéenne, modèle de surface
Abstract

Uncertainties in simulated evapotranspiration from land surface models over a 14-year Mediterranean crop succession. 5. Ileaps Science Conference

Published
2017

40. Public access to web-based project data products

Author

Kolb, M., Thonicke, K., Boit, A., Kooistra, L., Dutrieux, L.P., Herold, M., Cisowska, I., and Blyth, E.

Subjects
Laboratory of Geo-information Science and Remote Sensing, Life Science, Laboratorium voor Geo-informatiekunde en Remote Sensing, PE&RC
Published
2015

45. Hyperresolution global land surface modeling: Meeting a grand challenge for monitoring Earth's terrestrial water

Author

Wood, E.F., Roundy, J.K., Troy, T.J., Beek, L.P.H. van, Bierkens, M.F.P., Blyth, E., Roo, A.A. de, Doll, P., Ek, M., Famiglietti, J., Gochis, D., Giesen, N. van de, Houser, P., Jaffe, P.R., Kollet, S., Lehner, B., Lettenmaier, D.P., Peters-Liedard, C., Sivapalan, M., Sheffield, J., Wade, A., and Whitehead, P.

Subjects
inundation, Aardwetenschappen, multiple source assessment, equations, flow, consequences, Physical Sciences and Mathematics, part I, hydrology, nitrogen model, catchments Inca, simulation
Abstract

Monitoring Earth’s terrestrial water conditions is critically important to many hydrological applications such as global food production; assessing water resources sustainability; and flood, drought, and climate change prediction. These needs have motivated the development of pilot monitoring and prediction systems for terrestrial hydrologic and vegetative states, but to date only at the rather coarse spatial resolutions (∼10–100 km) over continental to global domains. Adequately addressing critical water cycle science questions and applications requires systems that are implemented globally at much higher resolutions, on the order of 1 km, resolutions referred to as hyperresolution in the context of global land surface models. This opinion paper sets forth the needs and benefits for a system that would monitor and predict the Earth’s terrestrial water, energy, and biogeochemical cycles. We discuss six major challenges in developing a system: improved representation of surface‐subsurface interactions due to fine‐scale topography and vegetation; improved representation of land‐atmospheric interactions and resulting spatial information on soil moisture and evapotranspiration; inclusion of water quality as part of the biogeochemical cycle; representation of human impacts from water management; utilizing massively parallel computer systems and recent computational advances in solving hyperresolution models that will have up to 109 unknowns; and developing the required in situ and remote sensing global data sets. We deem the development of a global hyperresolution model for monitoring the terrestrial water, energy, and biogeochemical cycles a “grand challenge” to the community, and we call upon the international hydrologic community and the hydrological science support infrastructure to endorse the effort.

Published
2011

46. Executive summary of the completed WATCH project

Author

Harding, R., Warnaars, T., Weedon, G.P., Wiberg, D., Hagemann, S., Tallaksen, L., van Lanen, H.A.J., Blyth, E., Ludwig, F., and Kabat, P.

Subjects
WIMEK, Leerstoelgroep Aardsysteemkunde, Life Science, Hydrology and Quantitative Water Management, Earth System Science, Hydrologie en Kwantitatief Waterbeheer
Published
2011

50. EBV+ CNS LYMPHOMAS HAVE A DISTINCTIVE TUMOR MICROENVIRONMENT AND GENETIC PROFILE, WHICH IS AMENABLE TO COMBINATION 3RD PARTY EBV‐SPECIFIC CTL AND IBRUTINIB THERAPY.

Author

Gandhi, M.K., Hoang, T., Tobin, J.W., Law, S.C., Talaulikar, D., Jain, S., Vari, F., Murigneux, V., Fink, L., Gunawardana, J., Gould, C., Oey, H., Delecluse, S., Trappe, R.U., Merida de Long, L., Sabdia, M.B., Bhagat, G., Hapgood, G., Blyth, E., and Clancy, L.

Subjects
TUMOR microenvironment, LYMPHOMAS, LYMPHOPROLIFERATIVE disorders, VIRAL antigens, ANTINEOPLASTIC combined chemotherapy protocols
Published
2019
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