34 results on '"Böker, J."'
Search Results
2. Storage ring to search for electric dipole moments of charged particles: Feasibility study
- Author
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Monographs, CERN Yellow Reports, Abusaif, F., Böhme, C., Zupranski, P., Zurek, M., Böker, J., Borburgh, J., Canale, N., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., De Conto, J.-M., Dymov, S., Aggarwal, A., Felden, Olaf, Gaisser, M., Gebel, Ralf Heinz, Giese, N., Gooding, J., Grigoryev, Kirill, Grzonka, D., Haj Tahar, M., Hahnraths, T., Heberling, D., Aksentev, A., Hejny, V., Hetzel, Jan Henry, Hölscher, D., Javakhishvili, O., Jorat, L., Kacharava, A., Kamerdzhiev, Vsevolod, Karanth, S., Keshelashvili, Irakli, Koop, I., Alberdi-Esuain, B., Kulikov, A., Laihem, Karim, Lamont, M., Lehrach, A., Lenisa, P., Lomidze, I., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Andres, A., Makino, K., Martin, S., Mchedlishvili, D., Meißner, U.-G., Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Atanasov, A., Nogga, A., Okropiridze, Dachi, Pesce, A., Poncza, V., Prasuhn, Dieter, Pretz, J., Rathmann, F., Ritman, James, Rosenthal, M., Saleev, A., Barion, L., Schott, M., Sefzick, T., Senichev, Y., Shankar, R., Shergelashvili, D., Shmakova, V., Siddique, Saad, Silenko, A., Simon, M., Slim, Jamal, Basile, S., Soltner, H., Stahl, A., Stassen, Rolf, Stephenson, E., Straatmann, H., Ströher, Hans, Tabidze, M., Tagliente, G., Talman, R., Uzikov, Y., Berz, M., Valdau, Yury, Valetov, E., Vilella, E., Vitz, M., Vossebeld, J., Wagner, Tim, Weidemann, C., Wirzba, A., Wronska, A., and Wüstner, P.
- Abstract
Geneva : CERN Yellow Reports: Monographs 22MB (2021). doi:10.23731/CYRM-2021-003, Published by CERN Yellow Reports: Monographs, Geneva
- Published
- 2021
- Full Text
- View/download PDF
3. Storage Ring to Search for Electric Dipole Moments of Charged Particles -- Feasibility Study
- Author
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Abusaif, F., Aggarwal, A., Aksentev, A., Alberdi-Esuain, B., Atanasov, A., Barion, L., Basile, S., Berz, M., Beyß, M., Böhme, C., Böker, J., Borburgh, J., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., De Conto, J.-M., Dymov, S., Felden, O., Gagoshidze, M., Gaisser, M., Gebel, R., Giese, N., Grigoryev, K., Grzonka, D., Haj Tahar, M., Hahnraths, T., Heberling, D., Hejny, V., Hetzel, J., Hölscher, D., Javakhishvili, O., Jorat, L., Kacharava, A., Kamerdzhiev, V., Karanth, S., Käseberg, C., Keshelashvili, I., Koop, I., Kulikov, A., Laihem, K., Lamont, M., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Makino, K., Martin, S., Mchedlishvili, D., Meißner, U.-G, Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nogga, A., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Saleev, A., Schott, M., Sefzick, T., Senichev, Y., Shergelashvili, D., Shmakova, V., Siddique, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stephenson, E., Straatmann, H., Ströher, H., Tabidze, M., Tagliente, G., Talman, R., Uzikov, Yu., Valdau, Yu., Valetov, E., Wagner, T., Weidemann, C., Wirzba, A., Wrońska, A., Wüstner, P., Zupranski, P., Zurek., M., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CERN, and CPEDM
- Subjects
lifetime ,experimental methods ,deuteron: electric moment ,[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph] ,feedback ,Juelich COSY PS ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,sensitivity ,charged particle ,particle: spin ,electric field ,particle: velocity ,error: statistical ,synchrotron ,dipole: electric ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,proposed experiment ,spin: polarization - Abstract
CERN Yellow Reports: Monographs Published by CERN; International audience; The proposed method exploits charged particles confined as a storage ring beam (proton, deuteron, possibly $^3$He) to search for an intrinsic electric dipole moment (EDM) aligned along the particle spin axis. Statistical sensitivities can approach $10^{29} e$ cm. The challenge will be to reduce systematic errors to similar levels. The ring will be adjusted to preserve the spin polarization, initially parallel to the particle velocity, for times in excess of 15 minutes. Large radial electric fields, acting through the EDM, will rotate the polarization. The slow rise in the vertical polarization component, detected through scattering from a target, signals the EDM. The project strategy is outlined. It foresees a step-wise plan, starting with ongoing COSY activities that demonstrate technical feasibility. Achievements to date include reduced polarization measurement errors, long horizontal-plane polarization lifetimes, and control of the polarization direction through feedback from the scattering measurements. The project continues with a proof-of-capability measurement (precursor experiment; first direct deuteron EDM measurement), an intermediate prototype ring (proof-of-principle; demonstrator for key technologies), and finally the high precision electric-field storage ring.
- Published
- 2021
4. Thermodynamics of transition to BCS-BEC crossover superconductivity in FeSe$_{1-x}$S$_x$
- Author
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Mizukami, Y., Haze, M., Tanaka, O., Matsuura, K., Sano, D., Böker, J., Eremin, I., Kasahara, S., Matsuda, Y., and Shibauchi, T.
- Subjects
Condensed Matter::Quantum Gases ,Superconductivity (cond-mat.supr-con) ,Condensed Matter - Superconductivity ,Condensed Matter::Superconductivity ,FOS: Physical sciences - Abstract
The BCS-BEC crossover from strongly overlapping Cooper pairs to non-overlapping composite bosons in the strong coupling limit has been a long-standing issue of interacting many-body fermion systems. Recently, FeSe semimetal with hole and electron bands emerged as a high-$T_{\rm c}$ superconductor located in the BCS-BEC crossover regime, owing to its very small Fermi energies. In FeSe, however, an ordinary BCS-like heat-capacity jump is observed at $T_{\rm c}$, posing a fundamental question on the characteristics of the BCS-BEC crossover. Here we report on high-resolution heat capacity, magnetic torque, and scanning tunneling spectroscopy measurements in FeSe$_{1-x}$S$_x$. Upon entering the tetragonal phase at $x>0.17$, where nematic order is suppressed, $T_{\rm c}$ discontinuously decreases. In this phase, highly non-mean-field behaviors consistent with BEC-like pairing are found in the thermodynamic quantities with giant superconducting fluctuations extending far above $T_{\rm c}$, implying the change of pairing nature. Moreover, the pseudogap formation, which is expected in BCS-BEC crossover of single-band superconductors, is not observed in the tunneling spectra. These results illuminate highly unusual features of the superconducting states in the crossover regime with multiband electronic structure and competing electronic instabilities., 12 pages, 8 figures
- Published
- 2021
- Full Text
- View/download PDF
5. Measurement of proton-proton elastic scattering into the Coulomb region at Pbeam = 2.5, 2.8 and 3.2 GeV/c
- Author
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Xu, H., primary, Zhou, Y., additional, Bechstedt, U., additional, Böker, J., additional, Gillitzer, A., additional, Goldenbaum, F., additional, Grzonka, D., additional, Hu, Q., additional, Khoukaz, A., additional, Klehr, F., additional, Lorentz, B., additional, Prasuhn, D., additional, Ritman, J., additional, Schadmand, S., additional, Sefzick, T., additional, Stockmanns, T., additional, Strakovsky, I.I., additional, Täschner, A., additional, Wilkin, C., additional, Workman, R.L., additional, and Wüstner, P., additional
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- 2021
- Full Text
- View/download PDF
6. A new beam polarimeter at COSY to search for electric dipole moments of charged particles
- Author
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Müller, F., primary, Javakhishvili, O., additional, Shergelashvili, D., additional, Keshelashvili, I., additional, Mchedlishvili, D., additional, Abusaif, F., additional, Aggarwal, A., additional, Barion, L., additional, Basile, S., additional, Böker, J., additional, Canale, N., additional, Ciullo, G., additional, Dymov, S., additional, Felden, O., additional, Gagoshidze, M., additional, Gebel, R., additional, Demary, N., additional, Grigoryev, K., additional, Grzonka, D., additional, Hahnraths, T., additional, Hejny, V., additional, Kacharava, A., additional, Kamerdzhiev, V., additional, Karanth, S., additional, Kulikov, A., additional, Lehrach, A., additional, Lenisa, P., additional, Lomidze, N., additional, Lorentz, B., additional, Macharashvili, G., additional, Magiera, A., additional, Metreveli, Z., additional, Nass, A., additional, Nikolaev, N.N., additional, Nioradze, M., additional, Pesce, A., additional, Poncza, V., additional, Prasuhn, D., additional, Pretz, J., additional, Rathmann, F., additional, Saleev, A., additional, Sefzick, T., additional, Senichev, Yu., additional, Shmakova, V., additional, Slim, J., additional, Soltner, H., additional, Stephenson, E., additional, Ströher, H., additional, Tabidze, M., additional, Tagliente, G., additional, Uzikov, Yu., additional, Valdau, Yu., additional, Wagner, T., additional, Wrońska, A., additional, Wüstner, P., additional, and Zurek, M., additional
- Published
- 2020
- Full Text
- View/download PDF
7. Evidence for an Fulde-Ferrell-Larkin-Ovchinnikov State with Segmented Vortices in the BCS-BEC-Crossover Superconductor FeSe
- Author
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Kasahara, S., Sato, Y., Licciardello, S., Culo, M., Arsenijevic, S., Ottenbros, T., Tominaga, T., Böker, J., Eremin, I., Shibauchi, T., Wosnitza, J., Hussey, N. E., Matsuda, Y., Kasahara, S., Sato, Y., Licciardello, S., Culo, M., Arsenijevic, S., Ottenbros, T., Tominaga, T., Böker, J., Eremin, I., Shibauchi, T., Wosnitza, J., Hussey, N. E., and Matsuda, Y.
- Published
- 2020
8. A New Beam Polarimeter at COSY to Search for Electric Dipole Moments of Charged Particles
- Author
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Müller, F., Javakhishvili, O., Shergelashvili, D., Keshelashvili, I., Mchedlishvili, D., Abusaif, F., Aggarwal, A., Barion, L., Basile, S., Böker, J., Canale, N., Ciullo, G., Dymov, S., Felden, O., Gagoshidze, M., Gebel, R., Demary, N., Grigoryev, K., Grzonka, D., Hahnraths, T., Hejny, V., Kacharava, A., Kamerdzhiev, V., Karanth, S., Kulikov, A., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Metreveli, Z., Nass, A., Nikolaev, N. N., Nioradze, M., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Saleev, A., Sefzick, T., Senichev, Yu., Shmakova, V., Slim, J., Soltner, H., Stephenson, E., Ströher, H., Tabidze, M., Tagliente, G., Uzikov, Yu., Valdau, Yu., Wagner, T., Wrońska, A., Wüstner, P., Żurek, M., Müller, F., Javakhishvili, O., Shergelashvili, D., Keshelashvili, I., Mchedlishvili, D., Abusaif, F., Aggarwal, A., Barion, L., Basile, S., Böker, J., Canale, N., Ciullo, G., Dymov, S., Felden, O., Gagoshidze, M., Gebel, R., Demary, N., Grigoryev, K., Grzonka, D., Hahnraths, T., Hejny, V., Kacharava, A., Kamerdzhiev, V., Karanth, S., Kulikov, A., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Metreveli, Z., Nass, A., Nikolaev, N. N., Nioradze, M., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Saleev, A., Sefzick, T., Senichev, Yu., Shmakova, V., Slim, J., Soltner, H., Stephenson, E., Ströher, H., Tabidze, M., Tagliente, G., Uzikov, Yu., Valdau, Yu., Wagner, T., Wrońska, A., Wüstner, P., and Żurek, M.
- Abstract
A calorimetric polarimeter based on inorganic LYSO scintillators is described. It has been designed for use in a storage ring to search for electric dipole moments (EDM) of charged particles such as the proton and deuteron. Its development and first use was on the Cooler Synchrotron (COSY) at the Forschungszentrum J\"ulich with 0.97 GeV/c polarized deuterons, a particle and energy suitable for an EDM search. The search requires a polarimeter with high efficiency, large analyzing power, and stable operating characteristics. With typical beam momenta of about 1 GeV/c, the scattering of protons or deuterons from a carbon target into forward angles becomes a nearly optimal choice of an analyzing reaction. The polarimeter described here consists of 52 LYSO detector modules, arranged in 4 symmetric blocks (up, down, left, right) for energy determination behind plastic scintillators for particle identification via energy loss. The commissioning results of the current setup demonstrate that the polarimeter is ready to be employed in a first direct search for an EDM on the deuteron, which is planned at COSY in the next two years.
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- 2020
- Full Text
- View/download PDF
9. Feasibility Study for an EDM Storage Ring
- Author
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Abusaif, F., Aggarwal, A., Aksentev, A., Alberdi-Esuain, B., Barion, L., Basile, S., Berz, M., Beyß, M., Böhme, C., Böker, J., Borburgh, J., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., M Conto, J., Dymov, S., Engels, R., Felden, O., Gagoshidze, M., Gaisser, M., Gebel, R., Giese, N., Grigoryev, K., Grzonka, D., Hanraths, T., Hanhart, C., Heberling, D., Hejny, V., Hetzel, J., Hölscher, D., Otari Javakhishvili, Kacharava, A., Karanth, S., Käseberg, C., Kamerdzhiev, V., Keshelashvili, I., Koop, I., Kulikov, A., Laihem, K., Lamont, M., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Maier, R., Makino, K., Martin, S., Mchedlishvili, D., G Meißner, U., Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nogga, A., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Saleev, A., Schott, M., Sefzick, T., Senichev, Y., Shergelashvili, D., Shmakova, V., Siddique, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stephenson, E., Straatmann, H., Ströher, H., Tabidze, M., Tagliente, G., Tahar, M., Talman, R., Yu. Uzikov, Yu. Valdau, Valetov, E., Wagner, T., Weidemann, C., Wilkin, C., Wirzba, A., Wrońska, A., Wüstner, P., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), and CPEDM
- Subjects
Accelerator Physics (physics.acc-ph) ,experimental methods ,deuteron: electric moment ,hep-ex ,[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph] ,FOS: Physical sciences ,costs ,Juelich COSY PS ,sensitivity ,Accelerators and Storage Rings ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,beam optics ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Physics - Accelerator Physics ,spin: polarization ,Nuclear Experiment ,Particle Physics - Experiment ,accelerator: design ,activity report ,physics.acc-ph - Abstract
This project exploits charged particles confined as a storage ring beam (proton, deuteron, possibly $^3$He) to search for an intrinsic electric dipole moment (EDM, $\vec d$) aligned along the particle spin axis. Statistical sensitivities can approach $10^{-29}$~e$\cdot$cm. The challenge will be to reduce systematic errors to similar levels. The ring will be adjusted to preserve the spin polarization, initially parallel to the particle velocity, for times in excess of 15 minutes. Large radial electric fields, acting through the EDM, will rotate the polarization ($\vec d \times\vec E$). The slow rise in the vertical polarization component, detected through scattering from a target, signals the EDM. The project strategy is outlined. It foresees a step-wise plan, starting with ongoing COSY activities that demonstrate technical feasibility. Achievements to date include reduced polarization measurement errors, long horizontal-plane polarization lifetimes, and control of the polarization direction through feedback from the scattering measurements. The project continues with a proof-of-capability measurement (precursor experiment; first direct deuteron EDM measurement), an intermediate prototype ring (proof-of-principle; demonstrator for key technologies), and finally the high precision electric-field storage ring.
- Published
- 2019
10. Evidence for an FFLO state with segmented vortices in the BCS-BEC-crossover superconductor FeSe
- Author
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Kasahara, S., Sato, Y., Licciardello, S., Čulo, M., Arsenijević, S., Ottenbros, T., Tominaga, T., Böker, J., Eremin, I., Shibauchi, T., Wosnitza, J., Hussey, N. E., and Matsuda, Y.
- Subjects
Condensed Matter::Quantum Gases ,Superconductivity (cond-mat.supr-con) ,Condensed Matter - Strongly Correlated Electrons ,Strongly Correlated Electrons (cond-mat.str-el) ,Quantum Gases (cond-mat.quant-gas) ,Condensed Matter - Superconductivity ,Condensed Matter::Superconductivity ,FOS: Physical sciences ,Condensed Matter - Quantum Gases - Abstract
We present resistivity and thermal-conductivity measurements of superconducting FeSe in intense magnetic fields up to 35 T applied parallel to the $ab$ plane. At low temperatures, the upper critical field $\mu_0 H_{c2}^{ab}$ shows an anomalous upturn, while thermal conductivity exhibits a discontinuous jump at $\mu_0 H^{\ast}\approx 24$ T well below $\mu_0 H_{c2}^{ab}$, indicating a first-order phase transition in the superconducting state. This demonstrates the emergence of a distinct field-induced superconducting phase. Moreover, the broad resistive transition at high temperatures abruptly becomes sharp upon entering the high-field phase, indicating a dramatic change of the magnetic-flux properties. We attribute the high-field phase to the Fulde-Ferrel-Larkin-Ovchinnikov (FFLO) state, where the formation of planar nodes gives rise to a segmentation of the flux-line lattice. We point out that strongly orbital-dependent pairing as well as spin-orbit interactions, the multiband nature, and the extremely small Fermi energy are important for the formation of the FFLO state in FeSe., Comment: 6 pages, 4 figures
- Published
- 2019
- Full Text
- View/download PDF
11. Evidence for an Fulde-Ferrell-Larkin-Ovchinnikov State with Segmented Vortices in the BCS-BEC-Crossover Superconductor FeSe
- Author
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Kasahara, S., primary, Sato, Y., additional, Licciardello, S., additional, Čulo, M., additional, Arsenijević, S., additional, Ottenbros, T., additional, Tominaga, T., additional, Böker, J., additional, Eremin, I., additional, Shibauchi, T., additional, Wosnitza, J., additional, Hussey, N. E., additional, and Matsuda, Y., additional
- Published
- 2020
- Full Text
- View/download PDF
12. Evidence for an Fulde-Ferrell-Larkin-Ovchinnikov State with Segmented Vortices in the BCS-BEC-Crossover Superconductor FeSe
- Author
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Kasahara, S., Sato, Y., Licciardello, S., Culo, M., Arsenijevic, S., Ottenbros, T., Tominaga, T., Böker, J., Eremin, I., Shibauchi, T., Wosnitza, J., Hussey, N. E., Matsuda, Y., Kasahara, S., Sato, Y., Licciardello, S., Culo, M., Arsenijevic, S., Ottenbros, T., Tominaga, T., Böker, J., Eremin, I., Shibauchi, T., Wosnitza, J., Hussey, N. E., and Matsuda, Y.
- Published
- 2019
13. Storage Ring to Search for Electric Dipole Moments of Charged Particles -- Feasibility Study
- Author
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Abusaif, F., Aggarwal, A., Aksentev, A., Alberdi-Esuain, B., Andres, A., Atanasov, A., Barion, L., Basile, S., Berz, M., Böhme, C., Böker, J., Borburgh, J., Canale, N., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., De Conto, J. -M., Dymov, S., Felden, O., Gaisser, M., Gebel, R., Giese, N., Gooding, J., Grigoryev, K., Grzonka, D., Tahar, M. Haj, Hahnraths, T., Heberling, D., Hejny, V., Hetzel, J., Hölscher, D., Javakhishvili, O., Jorat, L., Kacharava, A., Kamerdzhiev, V., Karanth, S., Keshelashvili, I., Koop, I., Kulikov, A., Laihem, K., Lamont, M., Lehrach, A., Lenisa, P., Lomidze, I., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Makino, K., Martin, S., Mchedlishvili, D., Meißner, U. -G., Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nogga, A., Okropiridze, D., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Saleev, A., Schott, M., Sefzick, T., Senichev, Y., Shankar, R., Shergelashvili, D., Shmakova, V., Siddique, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stephenson, E., Straatmann, H., Ströher, H., Tabidze, M., Tagliente, G., Talman, R., Uzikov, Y., Valdau, Y., Valetov, E., Vilella, E., Vitz, M., Vossebeld, J., Wagner, T., Weidemann, C., Wirzba, A., Wrońska, A., Wüstner, P., Zupranski, P., Żurek, M., Abusaif, F., Aggarwal, A., Aksentev, A., Alberdi-Esuain, B., Andres, A., Atanasov, A., Barion, L., Basile, S., Berz, M., Böhme, C., Böker, J., Borburgh, J., Canale, N., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., De Conto, J. -M., Dymov, S., Felden, O., Gaisser, M., Gebel, R., Giese, N., Gooding, J., Grigoryev, K., Grzonka, D., Tahar, M. Haj, Hahnraths, T., Heberling, D., Hejny, V., Hetzel, J., Hölscher, D., Javakhishvili, O., Jorat, L., Kacharava, A., Kamerdzhiev, V., Karanth, S., Keshelashvili, I., Koop, I., Kulikov, A., Laihem, K., Lamont, M., Lehrach, A., Lenisa, P., Lomidze, I., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Makino, K., Martin, S., Mchedlishvili, D., Meißner, U. -G., Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nogga, A., Okropiridze, D., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Saleev, A., Schott, M., Sefzick, T., Senichev, Y., Shankar, R., Shergelashvili, D., Shmakova, V., Siddique, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stephenson, E., Straatmann, H., Ströher, H., Tabidze, M., Tagliente, G., Talman, R., Uzikov, Y., Valdau, Y., Valetov, E., Vilella, E., Vitz, M., Vossebeld, J., Wagner, T., Weidemann, C., Wirzba, A., Wrońska, A., Wüstner, P., Zupranski, P., and Żurek, M.
- Abstract
The proposed method exploits charged particles confined as a storage ring beam (proton, deuteron, possibly $^3$He) to search for an intrinsic electric dipole moment (EDM) aligned along the particle spin axis. Statistical sensitivities could approach 10$^{-29}$ e$\cdot$cm. The challenge will be to reduce systematic errors to similar levels. The ring will be adjusted to preserve the spin polarisation, initially parallel to the particle velocity, for times in excess of 15 minutes. Large radial electric fields, acting through the EDM, will rotate the polarisation from the longitudinal to the vertical direction. The slow rise in the vertical polarisation component, detected through scattering from a target, signals the EDM. The project strategy is outlined. A stepwise plan is foreseen, starting with ongoing COSY activities that demonstrate technical feasibility. Achievements to date include reduced polarization measurement errors, long horizontal plane polarization lifetimes, and control of the polarization direction through feedback from scattering measurements. The project continues with a proof-of-capability measurement (precursor experiment; first direct deuteron EDM measurement), an intermediate prototype ring (proof-of-principle; demonstrator for key technologies), and finally a high-precision electric-field storage ring., Comment: 243 pages
- Published
- 2019
- Full Text
- View/download PDF
14. Quantum Vortex Core and Missing Pseudogap in the Multiband BCS-BEC Crossover Superconductor FeSe
- Author
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Hanaguri, T., primary, Kasahara, S., additional, Böker, J., additional, Eremin, I., additional, Shibauchi, T., additional, and Matsuda, Y., additional
- Published
- 2019
- Full Text
- View/download PDF
15. Feasibility Study for an EDM Storage Ring
- Author
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Abusaif, F., Aggarwal, A., Aksentev, A., Alberdi-Esuain, B., Barion, L., Basile, S., Berz, M., Beyß, M., Böhme, C., Böker, J., Borburgh, J., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., De Conto, J. -M., Dymov, S., Engels, R., Felden, O., Gagoshidze, M., Gaisser, M., Gebel, R., Giese, N., Grigoryev, K., Grzonka, D., Hanraths, T., Hanhart, C., Heberling, D., Hejny, V., Hetzel, J., Hölscher, D., Javakhishvili, O., Kacharava, A., Karanth, S., Käseberg, C., Kamerdzhiev, V., Keshelashvili, I., Koop, I., Kulikov, A., Laihem, K., Lamont, M., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Maier, R., Makino, K., Martin, S., Mchedlishvili, D., Meißner, U. -G., Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nogga, A., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Saleev, A., Schott, M., Sefzick, T., Senichev, Y., Shergelashvili, D., Shmakova, V., Siddique, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stephenson, E., Straatmann, H., Ströher, H., Tabidze, M., Tagliente, G., Tahar, M., Talman, R., Uzikov, Yu., Valdau, Yu., Valetov, E., Wagner, T., Weidemann, C., Wilkin, C., Wirzba, A., Wrońska, A., Wüstner, P., Abusaif, F., Aggarwal, A., Aksentev, A., Alberdi-Esuain, B., Barion, L., Basile, S., Berz, M., Beyß, M., Böhme, C., Böker, J., Borburgh, J., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., De Conto, J. -M., Dymov, S., Engels, R., Felden, O., Gagoshidze, M., Gaisser, M., Gebel, R., Giese, N., Grigoryev, K., Grzonka, D., Hanraths, T., Hanhart, C., Heberling, D., Hejny, V., Hetzel, J., Hölscher, D., Javakhishvili, O., Kacharava, A., Karanth, S., Käseberg, C., Kamerdzhiev, V., Keshelashvili, I., Koop, I., Kulikov, A., Laihem, K., Lamont, M., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Maier, R., Makino, K., Martin, S., Mchedlishvili, D., Meißner, U. -G., Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nogga, A., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Saleev, A., Schott, M., Sefzick, T., Senichev, Y., Shergelashvili, D., Shmakova, V., Siddique, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stephenson, E., Straatmann, H., Ströher, H., Tabidze, M., Tagliente, G., Tahar, M., Talman, R., Uzikov, Yu., Valdau, Yu., Valetov, E., Wagner, T., Weidemann, C., Wilkin, C., Wirzba, A., Wrońska, A., and Wüstner, P.
- Abstract
This project exploits charged particles confined as a storage ring beam (proton, deuteron, possibly $^3$He) to search for an intrinsic electric dipole moment (EDM, $\vec d$) aligned along the particle spin axis. Statistical sensitivities can approach $10^{-29}$~e$\cdot$cm. The challenge will be to reduce systematic errors to similar levels. The ring will be adjusted to preserve the spin polarization, initially parallel to the particle velocity, for times in excess of 15 minutes. Large radial electric fields, acting through the EDM, will rotate the polarization ($\vec d \times\vec E$). The slow rise in the vertical polarization component, detected through scattering from a target, signals the EDM. The project strategy is outlined. It foresees a step-wise plan, starting with ongoing COSY activities that demonstrate technical feasibility. Achievements to date include reduced polarization measurement errors, long horizontal-plane polarization lifetimes, and control of the polarization direction through feedback from the scattering measurements. The project continues with a proof-of-capability measurement (precursor experiment; first direct deuteron EDM measurement), an intermediate prototype ring (proof-of-principle; demonstrator for key technologies), and finally the high precision electric-field storage ring.
- Published
- 2018
16. Associations of insulin-like growth factor-I and insulin-like growth factor binding protein-3 with bone quality in the general adult population
- Author
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Böker, J., primary, Völzke, H., additional, Nauck, M., additional, Hannemann, A., additional, and Friedrich, N., additional
- Published
- 2018
- Full Text
- View/download PDF
17. How to reach a thousand-second in-plane polarization lifetime with 0.97−GeV/c deuterons in a storage ring
- Author
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Guidoboni, G., Stephenson, E., Böker, J., Wüstner, P., Zakrzewska, M., Zuprański, P., Zyuzin, D., Stroeher, Hans, Mey, Sebastian, Stahl, Achim, JEDI Collaboration, Böhme, C., Bsaisou, J., Chekmenev, S., Chiladze, D., Ciullo, G., Contalbrigo, M., de Conto, J.-M., Dymov, S., Engels, Ralf W., Andrianov, S., Esser, F. M., Eversmann, D., Felden, O., Gaisser, M., Gebel, R., Glückler, H., Goldenbaum, F., Grigoryev, K., Grzonka, D., Hahnraths, T., Augustyniak, W., Heberling, D., Hejny, V., Hempelmann, N., Hetzel, J., Hinder, F., Hipple, R., Hölscher, D., Ivanov, A., Kacharava, A., Kamerdzhiev, V., Bagdasarian, Z., Kamys, B., Keshelashvili, I., Khoukaz, A., Koop, I., Krause, H.-J., Krewald, S., Kulikov, A., Lehrach, A., Lenisa, P., Lomidze, N., Bai, M., Lorentz, B., Maanen, P., Macharashvili, G., Magiera, A., Maier, R., Makino, K., Mariański, B., Mchedlishvili, D., Meißner, Ulf-G., Mey, S., Baylac, M., Morse, W., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nioradze, M., Nowakowski, K., Orlov, Y., Pesce, A., Prasuhn, D., Bernreuther, W., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Rudy, Z., Saleev, A., Sefzick, T., Semertzidis, Y., Senichev, Y., Shmakova, V., Bertelli, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stassen, R., Statera, M., Stockhorst, H., Straatmann, H., Tabidze, M., Talman, R., Berz, M., Thörngren Engblom, P., Trinkel, F., Trzciński, A., Uzikov, Yu., Valdau, Yu., Valetov, E., Vassiliev, A., Weidemann, C., Wilkin, C., Wrońska, A., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), and JEDI
- Subjects
ANOMALOUS MAGNETIC-MOMENTS ,ELECTRIC-DIPOLE MOMENTS ,SENSITIVITY ,[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph] ,ddc:550 ,Socio-culturale ,Physics::Accelerator Physics ,Nuclear Experiment - Abstract
International audience; We observe a deuteron beam polarization lifetime near 1000 s in the horizontal plane of a magnetic storage ring (COSY). This long spin coherence time is maintained through a combination of beam bunching, electron cooling, sextupole field corrections, and the suppression of collective effects through beam current limits. This record lifetime is required for a storage ring search for an intrinsic electric dipole moment on the deuteron at a statistical sensitivity level approaching 10−29 e cm.
- Published
- 2016
- Full Text
- View/download PDF
18. Acceleration of collimated 45 MeV protons by collisionless shocks driven in low-density, large-scale gradient plasmas by a 1020 W/cm2, 1 µm laser
- Author
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Antici, P., primary, Boella, E., additional, Chen, S. N., additional, Andrews, D. S., additional, Barberio, M., additional, Böker, J., additional, Cardelli, F., additional, Feugeas, J. L., additional, Glesser, M., additional, Nicolaï, P., additional, Romagnani, L., additional, Scisciò, M., additional, Starodubtsev, M., additional, Willi, O., additional, Kieffer, J. C., additional, Tikhonchuk, V., additional, Pépin, H., additional, Silva, L. O., additional, Humières, E. d’, additional, and Fuchs, J., additional
- Published
- 2017
- Full Text
- View/download PDF
19. This title is unavailable for guests, please login to see more information.
- Author
-
Antici, P., Boella, E., Chen, Sophia, Andrews, D.S., Barberio, M., Böker, J., Cardelli, F., Feugeas, J.L., Glesser, M., Nicolaï, P., Romagnani, L., Scisciò, M., Starodubtsev, M., Willi, O., Kieffer, J.C., Tikhonchuk, V., Pépin, H., Silva, L.O., Humières, E.D., Fuchs, J., Antici, P., Boella, E., Chen, Sophia, Andrews, D.S., Barberio, M., Böker, J., Cardelli, F., Feugeas, J.L., Glesser, M., Nicolaï, P., Romagnani, L., Scisciò, M., Starodubtsev, M., Willi, O., Kieffer, J.C., Tikhonchuk, V., Pépin, H., Silva, L.O., Humières, E.D., and Fuchs, J.
- Abstract
A new type of proton acceleration stemming from large-scale gradients, low-density targets, irradiated by an intense near-infrared laser is observed. The produced protons are characterized by high-energies (with a broad spectrum), are emitted in a very directional manner, and the process is associated to relaxed laser (no need for high-contrast) and target (no need for ultra-thin or expensive targets) constraints. As such, this process appears quite effective compared to the standard and commonly used Target Normal Sheath Acceleration technique (TNSA), or more exploratory mechanisms like Radiation Pressure Acceleration (RPA). The data are underpinned by 3D numerical simulations which suggest that in these conditions a Low Density Collisionless Shock Acceleration (LDCSA) mechanism is at play, which combines an initial Collisionless Shock Acceleration (CSA) to a boost procured by a TNSA-like sheath field in the downward density ramp of the target, leading to an overall broad spectrum. Experiments performed at a laser intensity of 1020 W/cm2 show that LDCSA can accelerate, from ~1% critical density, mm-scale targets, up to 5 × 109 protons/MeV/sr/J with energies up to 45(±5) MeV in a collimated (~6° half-angle) manner.
- Published
- 2017
20. Dynamics and structure of self-generated magnetics fields on solids following high contrast, high intensity laser irradiation
- Author
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Albertazzi, B., primary, Chen, S. N., additional, Antici, P., additional, Böker, J., additional, Borghesi, M., additional, Breil, J., additional, Dervieux, V., additional, Feugeas, J. L., additional, Lancia, L., additional, Nakatsutsumi, M., additional, Nicolaï, Ph., additional, Romagnagni, L., additional, Shepherd, R., additional, Sentoku, Y., additional, Starodubtsev, M., additional, Swantusch, M., additional, Tikhonchuk, V. T., additional, Willi, O., additional, d'Humières, E., additional, Pépin, H., additional, and Fuchs, J., additional
- Published
- 2015
- Full Text
- View/download PDF
21. Priorities for nutrition content in a medical school curriculum: a national consensus of medical educators
- Author
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Weinsier, R L, Boker, J R, Brooks, C M, Kushner, R F, Visek, W J, Mark, D A, Lopez-S, A, Anderson, M S, and Block, K
- Published
- 1989
- Full Text
- View/download PDF
22. croci e fasci : Der italienische Kirchenbau in der Zeit des Faschismus, 1919-1945
- Author
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Monzo, Luigi and Böker, J.
- Subjects
Scuola Romana ,Rom ,Giuseppe Polvara ,Giovanni Costantini ,Novecento ,Mailand ,The arts ,fine & decorative arts ,Kirchenbau ,Italien ,Faschismus ,Opera di Soccorso ,Marcello Piacentini ,Architektur ,Moderne ,Razionalismo ,Opera Pontificia per la Preservazione della Fede ,Pontificia Commissione per l'Arte Sacra in Italia ,Scuola Beato Angelico ,Triveneto ,ddc:700 ,Eur ,E42 - Abstract
Die Zeit von 1919 bis 1945 ist in Italien geprägt vom politischen und gesellschaftlichen Ringen um eine neue Ordnung. Dabei erweist sich die Herrschaftspraxis des von Mussolini 1922 installierten faschistischen Regimes als Metrum der Entwicklungen. Trotz seiner heterogenen Ideologie gelingt dem mussolinischen Faschismus die Etablierung und Konsolidierung einer neuen Wirklichkeit, zu der auch die Verständigung mit der katholischen Kirche gehört. Diese Verständigung schafft wiederum die Voraussetzungen für eine im italienischen Einheitsstaat bislang beispiellose kirchenbauliche Expansion. Zugleich ist die Auseinandersetzung mit den Fragen einer zeitgemäßen repräsentativen Architektur sowohl dem Regime als auch der Kirche gemein. Im Spannungsfeld erhitzter Debatten, progressiver und traditionsverbundener Denkweisen, entfaltet sich die wechselvolle Geschichte der Suche nach einem neuen, der Lebenswirklichkeit des 20. Jahrhunderts angemessenen katholischen Kirchenbau. Unter dem begünstigenden Eindruck der faschistischen Architekturpolitik profitiert die kirchenbauliche Entwicklung von der Neuausrichtung der architektonischen Gemengelage, so dass sich schließlich ein Kirchenbau verfestigt, der die typische Verlustempfindlichkeit der Kirche überwindet und heute als Mittler zwischen der Kontinuität jahrhundertealter Traditionen und dem liturgisch motivierten Aufbruch der 1950er und 1960er Jahre gelesen werden kann.
- Published
- 2017
23. Die Holzbauten von Albinmüller. Eine planungsmethodische Untersuchung über die Entstehung der Holzbauten von Albinmüller aus dem Zeitraum von 1902 bis 1929
- Author
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Deist, Joerg and Böker, J. J.
- Subjects
The arts ,fine & decorative arts ,Darmstadt ,ddc:700 ,Magdeburg ,Architektur ,Albinmüller ,Holzbau - Abstract
In der Dissertation wurden die Holzbauten von Albinmüller systematisch erfasst und historisch eingeordnet. Die planungsmethodische Untersuchung über die Entstehung der Holzbauten von Albinmüller hat ergeben, dass Albinmüller durch die norwegische Holzbaukunst sowie durch die Architekten Hermann Muthesius, Friedrich Ostendorf und Frank Lloyd Wright beeinflusst wurde. Albinmüller wendete bei den Holzbauentwürfen von 1902 bis 1929 die Umgebinde-, Stab-, Tafel-, Block- und Fachwerkbauweise an.
- Published
- 2015
24. Der Architekt Heinrich Müller und die Bayrische Postbauschule in der Pfalz
- Author
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Werner, Wolfgang and Böker, J. J.
- Subjects
Post ,Pfalz ,Architecture ,Stätdtebau ,ddc:720 ,Architektur ,Universität Karlsruhe - Abstract
Zwischen den Kriegen Postbaurat in Speyer, verwirklichte Heinrich Müller eine Architektur im Dialog mit der Geschichte des jeweiligen Ortes und des allgemeinen kulturellen Gedächtnisses. Müller wechselte 1936 als Professor für Architektur zur damaligen Technischen Hochschule Karlsruhe. Bis heute zeugen der Gerthsen-Hörsaal und die Sporthalle am Forum von seinem Bebauungsplan von 1953 mit dem amerikanischen Ideal der grünen Mitte, eine gute Diskussionsbasis für die Fortentwicklung des KIT-Campus.
- Published
- 2012
- Full Text
- View/download PDF
25. Das Haus Wolters - Ein HOESCH-Fertighaus aus Stahl
- Author
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Krebs, Tim and Böker, J. J.
- Subjects
Architecture ,ddc:720 - Published
- 2012
- Full Text
- View/download PDF
26. Beck-Erlang, Das Werk des Architekten Wilfried Max Beck
- Author
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Wiertlewski, Carsten and Böker, J. J.
- Subjects
Ornamentik ,"Kunst und Bau" ,Denkmalschutz ,Architecture ,SAAI ,Nachkriegsarchitektur ,Op-Architecture ,ddc:720 ,"organisches Bauen" ,Beck-Erlang ,Stuttgart ,Reutlingen - Abstract
Der Stuttgarter Architekt Wilfried Max Beck (1924-2002) ist ein begabter Entwerfer, Vollblut-Architekt, Idealist und Baukünstler mit Leidenschaft. "Kämpferisch" titelt das BauNetz seinen Nachruf. Er hinterlässt ein eindrucksvolles Werk, das zunächst auch überregional viel Beachtung findet, sich aber seit den achtziger Jahren im aktuellen Kontext verliert. Zu Unrecht, wie diese Monographie zu zeigen versucht.
- Published
- 2012
27. Das Philippeion von Olympia. Ein partieller Wiederaufbau
- Author
-
Löcht, Hajo van de and Böker, J.
- Subjects
Philippeion ,Bauforschung ,archäologische ,The arts ,fine & decorative arts ,Olympia ,ddc:700 ,Wiederaufbau - Abstract
Die grundlegenden Forschungsergebnisse von H. Schleif (1944) und die aufgefundenen Bauglieder ließen eine "beinahe lückenlose" Rekonstruktion des Philippeion erwarten, so daß eine partielle Wiederherstellung desselben angestrebt wurde. Bei der Überprüfung der Forschungsergebnisse zeigten sich einige Unstimmigkeiten und bei der Vermessung der Bauglieder ergaben sich neue Ergebnisse, welche die bisherige Rekonstruktion in wesentlichen Punkten korrigieren und ergänzen.
- Published
- 2008
- Full Text
- View/download PDF
28. Acceleration of collimated 45 MeV protons by collisionless shocks driven in low-density, large-scale gradient plasmas by a 10 20 W/cm 2 , 1 µm laser.
- Author
-
Antici P, Boella E, Chen SN, Andrews DS, Barberio M, Böker J, Cardelli F, Feugeas JL, Glesser M, Nicolaï P, Romagnani L, Scisciò M, Starodubtsev M, Willi O, Kieffer JC, Tikhonchuk V, Pépin H, Silva LO, Humières E, and Fuchs J
- Abstract
A new type of proton acceleration stemming from large-scale gradients, low-density targets, irradiated by an intense near-infrared laser is observed. The produced protons are characterized by high-energies (with a broad spectrum), are emitted in a very directional manner, and the process is associated to relaxed laser (no need for high-contrast) and target (no need for ultra-thin or expensive targets) constraints. As such, this process appears quite effective compared to the standard and commonly used Target Normal Sheath Acceleration technique (TNSA), or more exploratory mechanisms like Radiation Pressure Acceleration (RPA). The data are underpinned by 3D numerical simulations which suggest that in these conditions a Low Density Collisionless Shock Acceleration (LDCSA) mechanism is at play, which combines an initial Collisionless Shock Acceleration (CSA) to a boost procured by a TNSA-like sheath field in the downward density ramp of the target, leading to an overall broad spectrum. Experiments performed at a laser intensity of 10
20 W/cm2 show that LDCSA can accelerate, from ~1% critical density, mm-scale targets, up to 5 × 109 protons/MeV/sr/J with energies up to 45(±5) MeV in a collimated (~6° half-angle) manner.- Published
- 2017
- Full Text
- View/download PDF
29. How to Reach a Thousand-Second in-Plane Polarization Lifetime with 0.97-GeV/c Deuterons in a Storage Ring.
- Author
-
Guidoboni G, Stephenson E, Andrianov S, Augustyniak W, Bagdasarian Z, Bai M, Baylac M, Bernreuther W, Bertelli S, Berz M, Böker J, Böhme C, Bsaisou J, Chekmenev S, Chiladze D, Ciullo G, Contalbrigo M, de Conto JM, Dymov S, Engels R, Esser FM, Eversmann D, Felden O, Gaisser M, Gebel R, Glückler H, Goldenbaum F, Grigoryev K, Grzonka D, Hahnraths T, Heberling D, Hejny V, Hempelmann N, Hetzel J, Hinder F, Hipple R, Hölscher D, Ivanov A, Kacharava A, Kamerdzhiev V, Kamys B, Keshelashvili I, Khoukaz A, Koop I, Krause HJ, Krewald S, Kulikov A, Lehrach A, Lenisa P, Lomidze N, Lorentz B, Maanen P, Macharashvili G, Magiera A, Maier R, Makino K, Mariański B, Mchedlishvili D, Meißner UG, Mey S, Morse W, Müller F, Nass A, Natour G, Nikolaev N, Nioradze M, Nowakowski K, Orlov Y, Pesce A, Prasuhn D, Pretz J, Rathmann F, Ritman J, Rosenthal M, Rudy Z, Saleev A, Sefzick T, Semertzidis Y, Senichev Y, Shmakova V, Silenko A, Simon M, Slim J, Soltner H, Stahl A, Stassen R, Statera M, Stockhorst H, Straatmann H, Ströher H, Tabidze M, Talman R, Thörngren Engblom P, Trinkel F, Trzciński A, Uzikov Y, Valdau Y, Valetov E, Vassiliev A, Weidemann C, Wilkin C, Wrońska A, Wüstner P, Zakrzewska M, Zuprański P, and Zyuzin D
- Abstract
We observe a deuteron beam polarization lifetime near 1000 s in the horizontal plane of a magnetic storage ring (COSY). This long spin coherence time is maintained through a combination of beam bunching, electron cooling, sextupole field corrections, and the suppression of collective effects through beam current limits. This record lifetime is required for a storage ring search for an intrinsic electric dipole moment on the deuteron at a statistical sensitivity level approaching 10^{-29} e cm.
- Published
- 2016
- Full Text
- View/download PDF
30. Amphiphilic amide nitrones: a new class of protective agents acting as modifiers of mitochondrial metabolism.
- Author
-
Durand G, Poeggeler B, Ortial S, Polidori A, Villamena FA, Böker J, Hardeland R, Pappolla MA, and Pucci B
- Subjects
- Animals, Benzothiazoles chemistry, Brain drug effects, Free Radical Scavengers chemical synthesis, Free Radical Scavengers chemistry, Free Radical Scavengers pharmacology, Hydrogen Peroxide chemistry, Magnetic Resonance Spectroscopy, Membrane Potential, Mitochondrial drug effects, Mitochondria drug effects, Nitrogen Oxides chemical synthesis, Optical Rotation, Oxidation-Reduction, Rats, Rats, Sprague-Dawley, Spectrometry, Mass, Electrospray Ionization, Sulfonic Acids chemistry, Surface-Active Agents chemical synthesis, Surface-Active Agents chemistry, Brain metabolism, Mitochondria metabolism, Nitrogen Oxides chemistry, Nitrogen Oxides pharmacology, Oxidative Stress drug effects, Surface-Active Agents pharmacology
- Abstract
Our group has demonstrated that the amphiphilic character of alpha-phenyl-N-tert-butyl nitrone based agents is a key feature in determining their bioactivity and protection against oxidative toxicity. In this work, we report the synthesis of a new class of amphiphilic amide nitrones. Their hydroxyl radical scavenging activity and radical reducing potency were shown using ABTS competition and ABTS(+) reduction assays, respectively. Cyclic voltammetry was used to investigate their redox behavior, and the effects of the substitution of the PBN on the charge density of the nitronyl atoms, the electron affinity, and the ionization potential were computationally rationalized. The protective effects of amphiphilic amide nitrones in cell cultures exposed to oxidotoxins greatly exceeded those exerted by the parent compound PBN. They decreased electron and proton leakage as well as hydrogen peroxide formation in isolated rat brain mitochondria at nanomolar concentration. They also significantly enhanced mitochondrial membrane potential. Finally, dopamine-induced inhibition of complex I activity was antagonized by pretreatment with these agents. These findings indicate that amphiphilic amide nitrones are much more than just radical scavenging antioxidants but may act as a new class of bioenergetic agents directly on mitochondrial electron and proton transport.
- Published
- 2010
- Full Text
- View/download PDF
31. Fine-tuning the amphiphilicity: a crucial parameter in the design of potent alpha-phenyl-N-tert-butylnitrone analogues.
- Author
-
Durand G, Poeggeler B, Böker J, Raynal S, Polidori A, Pappolla MA, Hardeland R, and Pucci B
- Subjects
- Animals, Antioxidants chemistry, Antioxidants pharmacology, Cells, Cultured, Disaccharides chemical synthesis, Disaccharides chemistry, Disaccharides pharmacology, Drug Design, Electron Transport Complex I metabolism, In Vitro Techniques, Nitrogen Oxides chemistry, Nitrogen Oxides pharmacology, Rats, Rotifera drug effects, Structure-Activity Relationship, Submitochondrial Particles drug effects, Submitochondrial Particles metabolism, Tromethamine analogs & derivatives, Tromethamine chemical synthesis, Tromethamine chemistry, Tromethamine pharmacology, Antioxidants chemical synthesis, Cyclic N-Oxides chemistry, Nitrogen Oxides chemical synthesis
- Abstract
A new series of hydrophilic, lipophilic, and amphiphilic alpha-phenyl-N-tert-butylnitrone (PBN) derivatives were synthesized to explore the relationship between their hydrophilic-lipophilic properties and antioxidant potency. Very potent protective effects of amphiphilic lactobionamide and tris(hydroxymethyl)aminomethane PBN derivatives were observed in mitochondrial preparations, in cell cultures, and in rotifers exposed to unspecific and mitochondria targeted oxidotoxins.
- Published
- 2007
- Full Text
- View/download PDF
32. Toxicity of the quinalphos metabolite 2-hydroxyquinoxaline: growth inhibition, induction of oxidative stress, and genotoxicity in test organisms.
- Author
-
Riediger S, Behrends A, Croll B, Vega-Naredo I, Hänig N, Poeggeler B, Böker J, Grube S, Gipp J, Coto-Montes A, Haldar C, and Hardeland R
- Subjects
- Animals, Dinoflagellida genetics, Dinoflagellida growth & development, Insecticides metabolism, Insecticides toxicity, Light, Luminescent Measurements, Mutagenicity Tests, Organothiophosphorus Compounds metabolism, Oxidation-Reduction, Paramecium genetics, Paramecium growth & development, Quinoxalines metabolism, Salmonella typhimurium genetics, Salmonella typhimurium growth & development, Time Factors, Cell Proliferation drug effects, Dinoflagellida drug effects, Organothiophosphorus Compounds toxicity, Oxidative Stress drug effects, Paramecium drug effects, Quinoxalines toxicity, Salmonella typhimurium drug effects
- Abstract
The quinalphos metabolite 2-hydroxyquinoxaline (HQO), previously shown to photocatalytically destroy antioxidant vitamins and biogenic amines in vitro, was tested for toxicity in several small aquatic organisms and for mutagenicity in Salmonella typhimurium. In the rotifer Philodina acuticornis, HQO caused the disappearance of large individuals and increased hydroperoxide concentration. The latter effect was not only observed in animals kept in a light/dark cycle, but also in constant darkness, indicating that HQO can assume a reactive state and/or form reactive intermediates under the influence of either light or redox-active metabolites, in particular, free radicals. Cell proliferation was inhibited in the ciliate Paramecium bursaria. In the dinoflagellate Lingulodinium polyedrum, which allows early detection of cellular stress on the basis of bioluminescence measurements, strong rises in light emission became apparent on the 2nd day of exposure to HQO and continued until cells died between 12 and 18 days of treatment. Oxidative damage of protein by HQO was demonstrated by measuring protein carbonyl in L. polyedrumin vivo as well as in light-exposed bovine serum albumin in vitro. In an Ames test of mutagenicity, HQO proved to be genotoxic in both light- and dark-exposed bacteria. HQO appears as a source of secondary quinalphos toxicity, which deserves further attention.
- Published
- 2007
- Full Text
- View/download PDF
33. Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents.
- Author
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Ortial S, Durand G, Poeggeler B, Polidori A, Pappolla MA, Böker J, Hardeland R, and Pucci B
- Subjects
- Amino Acids chemical synthesis, Animals, Cell Death drug effects, Cells, Cultured, Chemical Phenomena, Chemistry, Physical, Doxorubicin toxicity, Hydrogen Peroxide pharmacology, Hydrogen Peroxide toxicity, Molecular Structure, Oxidation-Reduction, Protective Agents chemistry, Protective Agents classification, Surface-Active Agents chemical synthesis, Surface-Active Agents classification, Surface-Active Agents pharmacology, Amino Acids chemistry, Amino Acids pharmacology, Antioxidants chemistry, Fluorine chemistry, Protective Agents chemical synthesis, Protective Agents pharmacology, Surface-Active Agents chemistry
- Abstract
The use of classical antioxidants is limited by their low bioavailabilities, and therefore, high doses are usually required to display significant protective activity. In a recent article (J. Med. Chem. 2003, 46, 5230) we showed that the ability of the alpha-phenyl-N-tert-butylnitrone (PBN) to restore the viability of ATPase-deficient human skin fibroblasts was greatly enhanced by grafting it on a fluorinated amphiphilic carrier. With the aim of extending this concept to other antioxidants, we present here the design, the synthesis, and the physicochemical measurements of a new series of fluorinated amphiphilic antioxidant derivatives. The hydroxyl radical scavenging activity and the radical reducing potency of these newly designed compounds were respectively demonstrated in an ABTS competition and an ABTS(*+) reduction assay. We also showed that the protective effects of amphiphilic antioxidants derived from PBN, Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) or lipoic acid (5-[1,2]-dithiolan-3-ylpentanoic acid) in primary cortical mixed cell cultures exposed to oxidotoxins are greatly improved compared to their parent compounds in the following rank-order: (1) PBN, (2) Trolox, and (3) lipoic acid. In contrast, the protective activity of indole-3-propionic acid was slightly decreased by grafting it on the amphiphilic carrier. Similar observations were made in in vivo experiments using aquatic invertebrate microorganisms, called rotifers, which were exposed to lethal concentrations of nonselective (H(2)O(2)) and mitochondria-selective (doxorubicin) oxidotoxins. The conclusion of these studies is that fluorinated amphiphilic PBN, Trolox, and lipoic acid derivatives exhibit very potent protective activities in in vitro and in vivo experiments. The findings demonstrated herein therefore strongly suggest that the amphiphilic character enhances the bioavailability of the antioxidants and allows for a selective targeting of mitochondria.
- Published
- 2006
- Full Text
- View/download PDF
34. Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent.
- Author
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Poeggeler B, Durand G, Polidori A, Pappolla MA, Vega-Naredo I, Coto-Montes A, Böker J, Hardeland R, and Pucci B
- Subjects
- Aging drug effects, Aging physiology, Amyloid beta-Peptides toxicity, Animals, Cell Line, Tumor, Cell Survival drug effects, Diagnostic Imaging methods, Disaccharides chemical synthesis, Disaccharides chemistry, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Interactions, Humans, Hydrogen Peroxide toxicity, Imines chemical synthesis, Imines chemistry, Mitochondrial Diseases chemically induced, Mitochondrial Diseases mortality, Neuroblastoma, Neuroprotective Agents chemical synthesis, Neuroprotective Agents chemistry, Nitrogen Oxides chemical synthesis, Nitrogen Oxides chemistry, Oxidative Stress drug effects, Rotifera drug effects, Disaccharides therapeutic use, Imines therapeutic use, Life Expectancy, Mitochondrial Diseases prevention & control, Neuroprotective Agents therapeutic use, Nitrogen Oxides therapeutic use
- Abstract
The search for effective treatments that prevent oxidative stress associated with premature ageing and neurodegenerative diseases is an important area of neurochemical research. As age- and disease-related oxidative stress is frequently associated with mitochondrial dysfunction, amphiphilic antioxidant agents of high stability and selectivity that target these organelles can provide on-site protection. Such an amphiphilic nitrone protected human neuroblastoma cells at low micromolar concentrations against oxidative damage and death induced by exposure to the beta-amyloid peptide, hydrogen peroxide and 3-hydroxykynurenine. Daily administration of the antioxidant at a concentration of only 5 mum significantly increased the lifespan of the individually cultured rotifer Philodina acuticornis odiosa Milne. This compound is unique in its exceptional anti-ageing efficacy, being one order of magnitude more potent than any other compound previously tested on rotifers. The nitrone protected these aquatic animals against the lethal toxicity of hydrogen peroxide and doxorubicin and greatly enhanced their survival when co-administered with these oxidotoxins. These findings indicate that amphiphilic antioxidants have a great potential as neuroprotective agents in preventing the death of cells and organisms exposed to enhanced oxidative stress and damage.
- Published
- 2005
- Full Text
- View/download PDF
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