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We determined the number of days required, and whether to include weekdays and/or weekends, to obtain reliable measures of ambulatory physical activity in people with Parkinson's disease (PD). Ninety-two persons with PD wore a step activity monitor for seven days. The number of days required to obtain a reliable estimate of daily activity was determined from the mean intraclass correlation (ICC2,1) for all possible combinations of 1-6 consecutive days of monitoring. Two days of monitoring were sufficient to obtain reliable daily activity estimates (ICC2,1 > 0.9). Amount (p = 0.03) but not intensity (p = 0.13) of ambulatory activity was greater on weekdays than weekends. Activity prescription based on amount rather than intensity may be more appropriate for people with PD. [ABSTRACT FROM AUTHOR]

Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method. 109 older adults with a variety of comorbid disease conditions were examined for thigh muscle composition via MRI, knee extensor strength via isometric dynamometry, and mobility function. The contribution of strength, quadriceps lean tissue, and IMAT to explaining the variability in mobility function was examined using multivariate linear regression models. Results. The predictors as a group contributed 27-45% of the variance in all outcome measures; however, IMAT contributed between 8-15% of the variance in all four mobility variables, while lean explained only 5% variance in only one mobility measure. Conclusions. Thigh IMAT, a newly identified muscle impairment appears to be a potent muscle variable related to the ability of older adults to move about in their community. [ABSTRACT FROM AUTHOR]

After a stroke, the weight-bearing asymmetry often forces stroke survivors to compensate with overuse of the unaffected side muscles to stand up. Powered exoskeletons can address this problem by assisting the affected limb during sit-tostand transitions. However, there is currently no experimental evidence demonstrating the efficacy of this intervention with the target population. This study explores controlling a powered knee exoskeleton with EMG signals to assist a stroke patient during sit-to-stand transitions. Our results show decreased peak knee torques by 6.24% and 11.9% on their unaffected and affected sides, respectively, while wearing the exoskeleton. Additionally, the peak value of the EMG signal decreased by 29.3% and 21.9%, and the integrated EMG signal value decreased by 46.7% and 36.1% on their affected vastus medialis and lateralis while wearing the exoskeleton, respectively. Finally, our results indicate improved medial-lateral balance by 61.2%, 81.6%, and 70.0% based on the degree of asymmetry (DOA), the center of pressure (COP), and the center of mass (COM), respectively. These results support the efficacy of using powered exoskeletons for high-torque tasks such as sit-to-stand transitions with stroke survivors.

Background: Psychometric properties of tests that assess the angular vestibulo-ocular reflex (aVOR) and vestibulospinal reflex function are currently unknown. This study investigated the test-retest reliability and response stability of gaze stabilization, postural sway, and dynamic balance measures in persons with multiple sclerosis (MS) and controls., Methods: Nineteen adults with MS and 14 controls performed passive horizontal head impulses, quiet standing, and dynamic balance tests on two separate occasions. Gaze stabilization measures included aVOR gain, number of compensatory saccades (CSs) per head rotation, CS latency, and gaze position error. Postural sway included sway amplitude and total sway path. Dynamic balance measure included the Functional Gait Assessment. Intraclass correlation coefficient, standard error of measurement (SEM, SEM%), and minimal detectable difference at 95% confidence level were calculated., Results: Test-retest reliability for aVOR gain, CSs per head rotation, and gaze position error was moderate and for each postural sway and dynamic balance measure was good. Low error (SEM, SEM%) for aVOR gain, CS latency, postural sway, and dynamic balance variables and low minimal detectable difference values for aVOR gain and Functional Gait Assessment scores were seen, suggestive of acceptable response stability., Conclusions: These results support the utility of some of the gaze and postural measures for examination and treatment efficacy purposes in people with MS., Competing Interests: Financial Disclosures: The authors declare no conflicts of interest., (© 2020 Consortium of Multiple Sclerosis Centers.)