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2. Elastin is an essential determinant of arterial morphogenesis

Author

Li, Dean Y., Brooke, Benjamin, Davis, Elaine C., Mecham, Robert P., Sorensen, Lise K., Boak, Beth B., Eichwald, Ernst, and Keating, Mark T.

Subjects
Elastin -- Research, Arterial occlusions -- Causes of, Morphogenesis -- Research, Arteries -- Microbiology, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Elastin is the main constituent of the extracellular matrix of arteries and was believed to have a solely structural role. A new study investigates the role of elastin by generating mice without elastin in their arteries. The death of these mice is caused by an obstructive arterial disease resulting from subendothelial cell proliferation and smooth muscle reorganization. It is concluded that elastin has an unexpected regulatory function during arterial development.

Published
1998

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