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1. The interaction of patients’ physical status and time to endoscopy on mortality risk in patients with upper gastrointestinal bleeding: A national prospective cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Balzano, A, Bazzoli, F, Bennato, R, Bianco, M A, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De Fanis, C, De Filippo, FR, de Franchis, R, Dell‘Era, A, De Nigris, F, De Matthaeis, M, Di Giorgio, P, Di Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana’, B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R, Metrangolo, S, Montalbano, L M, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Bucci, Cristina, Marmo, Clelia, Soncini, Marco, Riccioni, Maria Elena, Laursen, Stig B., Gralnek, Ian M., and Marmo, Riccardo

Published
2024
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2. T.06.4: DISORDERS OF THE GUT-BRAIN AXIS IN PATIENTS WITH CELIAC DISEASE ADHERING TO GLUTEN FREE DIET: A PROSPECTIVE 10- YEAR STUDY

Author

Colecchia, L., primary, Candia, F., additional, Gobbato, A., additional, Di Biase, A.R., additional, Crestani, S., additional, Cammarota, G., additional, Boarino, V., additional, Dajti, E., additional, Ravaioli, F., additional, Cremon, C., additional, Barbara, G., additional, Colecchia, A., additional, Iughetti, L., additional, and Marasco, G., additional

Published
2024
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3. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Bazzoli, F, Bennato, R, Bianco, MA, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De-Fanis, C, De-Filippo, FR, de-Franchis, R, Dell‘Era, A, De Nigris, F, De-Matthaeis, M, Di-Giorgio, P, Di-Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana', B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R., Metrangolo, S, Montalbano, LM, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Marmo, Riccardo, Soncini, Marco, Bucci, Cristina, and Zullo, Angelo

Published
2021
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5. T.01.10 ITALIAN SOCIETY FOR DIGESTIVE ENDOSCOPY (SIED), ITALIAN ASSOCIATION OF HEALTHCARE TECHNICAL OPERATORS (ANOTE) AND ACCREDITATION ASSESSMENT: EVALUATION OF MANAGEMENT AND ORGANIZATIONAL EFFICACY WITH A NOVEL REMOTE ACCREDITATION METHOD IN 15 CENTRES

Author

Boarino, V., primary, Milano, A., additional, Brosolo, P., additional, Da Massa Carrara, P., additional, Iannone, T., additional, Merighi, A., additional, Labardi, M., additional, Rando, G., additional, Capelli, M., additional, and Spinzi, G., additional

Published
2023
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7. Derivation and validation of Re.Co.De death score risk in patients with acute nonvariceal upper GI bleeding

Author

Riccardo Marmo, Marco Soncini, Cristina Bucci, Vincenzo Occhipinti, Lucienne Pellegrini, Angelo Zullo, Amitrano L, Andriulli A, Annese V, Baldassarre G, Bargiggia S, Balzano A, Bazzoli F, Bennato R, Bianco M A, Bizzotto A, Boarino V, Bonanomi AG, Borgheresi P, Bresci G, Buffoli F, Buscarini E, Castrignanò G, Cavallaro LG, Cesaro P, Chirico A, Cipolletta F, Cipolletta L, Conigliaro R, Conte D, Costamagna G, D’ Amico G, De Fanis C, De Filippo FR, de Franchis R, Dell‘ Era A, De Nigris F, De Matthaeis M, Di Giorgio P, Di Giulio E, Esposito P, Ferraris L, Filippino A, Franceschi M, Furio L, Germana B, Grassia R, Imperiali G, Lamanda R, Lauri A, Londoni C, Mangiafico S, Manno M, Marmo C, Meroni R, Metrangolo S, Montalbano L. M, Napolitano G, Nucci A, Orsini L, Parente F, Parravicini M, Paterlini A, Pumpo R, Purita L, Repici A, Riccioni ME, Russo A, Segato S, Sorrentino I, Spinzi G, Spotti D, Tortora A, Triossi O, Zagari RM, and Zambelli A

Subjects
Cohort Studies, Area Under Curve, Acute Disease, Gastroenterology, Humans, Radiology, Nuclear Medicine and imaging, Gastrointestinal Hemorrhage, Prognosis, Risk Assessment, Severity of Illness Index
Abstract

Scores in upper GI bleeding (UGIB) are used to stratify death risk and need for hospitalization at admission, but a tool that incorporates dynamic changes during the hospital stay is lacking. We aimed to develop a death risk score that considers changes in clinical status during hospitalization and compare its performance with existing ones.A multicenter cohort study enrolling patients with UGIB in 50 Italian hospitals from January 2014 to December 2015 was conducted. Data were collected and used to develop a risk score using logistic regression analyses. Performance curves (area under the receiver-operating characteristic [AUROC] curves), sensitivities, specificities, positive and negative predictive values, and outcomes classified as low, intermediate, and high death risk were calculated. The score's performance was externally validated and then compared with other scores.We included 1852 patients with nonvariceal UGIB in the development cohort and 912 in the validation cohorts. The new score, which we named the Re.Co.De (rebleeding-comorbidities-deteriorating) score, included 10 variables depicting the changes in clinical conditions while in the hospital. The mortality AUROC curves were .93 (95% confidence interval, .91-.96) in the derivation cohort and .94 (95% confidence interval, .91-.98) in validation cohort. In a comparison of AUROC curves with other scores, the new score showed a significant performance compared with pre- and postendoscopy scores. Patients with low and high scores had 30-day mortality rates of .001% and 48.2%, respectively.The Re.Co.De score has a higher performance for predicting mortality in patients with UGIB compared with other scores, correctly identifying patients at low and high death risk while in the hospital through a dynamic re-evaluation of clinical status.

Published
2021

8. Endo-therapies for biliary duct-to-duct anastomotic stricture after liver transplantation: Outcomes of a nationwide survey

Author

Cantu, P, Tarantino, I, Baldan, A, Mutignani, M, Tringali, A, Lombardi, G, Cerofolini, A, Di Sario, A, Catalano, G, Bertani, H, Ghinolfi, D, Boarino, V, Masci, E, Bulajic, M, Pisani, A, Fantin, A, Ligresti, D, Barresi, L, Traina, M, Ravelli, P, Forti, E, Barbaro, F, Costamagna, G, Rodella, L, Maroni, L, Salizzoni, M, Conigliaro, R, Filipponi, F, Merighi, A, Staiano, T, Monteleone, M, Mazzaferro, V, Zucchi, E, Zilli, M, Nadal, E, Rosa, R, Santi, G, Parzanese, I, De Carlis, L, Donato, M, Lampertico, P, Maggi, U, Caccamo, L, Rossi, G, Vecchi, M, Penagini, R, Cantu P., Tarantino I., Baldan A., Mutignani M., Tringali A., Lombardi G., Cerofolini A., Di Sario A., Catalano G., Bertani H., Ghinolfi D., Boarino V., Masci E., Bulajic M., Pisani A., Fantin A., Ligresti D., Barresi L., Traina M., Ravelli P., Forti E., Barbaro F., Costamagna G., Rodella L., Maroni L., Salizzoni M., Conigliaro R., Filipponi F., Merighi A., Staiano T., Monteleone M., Mazzaferro V., Zucchi E., Zilli M., Nadal E., Rosa R., Santi G., Parzanese I., De Carlis L., Donato M. F., Lampertico P., Maggi U., Caccamo L., Rossi G., Vecchi M., Penagini R., Cantu, P, Tarantino, I, Baldan, A, Mutignani, M, Tringali, A, Lombardi, G, Cerofolini, A, Di Sario, A, Catalano, G, Bertani, H, Ghinolfi, D, Boarino, V, Masci, E, Bulajic, M, Pisani, A, Fantin, A, Ligresti, D, Barresi, L, Traina, M, Ravelli, P, Forti, E, Barbaro, F, Costamagna, G, Rodella, L, Maroni, L, Salizzoni, M, Conigliaro, R, Filipponi, F, Merighi, A, Staiano, T, Monteleone, M, Mazzaferro, V, Zucchi, E, Zilli, M, Nadal, E, Rosa, R, Santi, G, Parzanese, I, De Carlis, L, Donato, M, Lampertico, P, Maggi, U, Caccamo, L, Rossi, G, Vecchi, M, Penagini, R, Cantu P., Tarantino I., Baldan A., Mutignani M., Tringali A., Lombardi G., Cerofolini A., Di Sario A., Catalano G., Bertani H., Ghinolfi D., Boarino V., Masci E., Bulajic M., Pisani A., Fantin A., Ligresti D., Barresi L., Traina M., Ravelli P., Forti E., Barbaro F., Costamagna G., Rodella L., Maroni L., Salizzoni M., Conigliaro R., Filipponi F., Merighi A., Staiano T., Monteleone M., Mazzaferro V., Zucchi E., Zilli M., Nadal E., Rosa R., Santi G., Parzanese I., De Carlis L., Donato M. F., Lampertico P., Maggi U., Caccamo L., Rossi G., Vecchi M., and Penagini R.

Abstract

Background: The most appropriate endo-therapeutic approach to biliary anastomotic strictures is yet to be defined. Aim: To retrospectively report on the endo-therapy of duct-to-duct anastomotic strictures during 2013 in Italy. Methods: Data were collected from 16 Endoscopy Units at the Italian Liver Transplantation Centers (BASALT study group). Results: Complete endo-therapy and follow-up data are available for 181 patients: 101 treated with plastic multistenting, 26 with fully covered self-expandable metal stenting and 54 with single stenting. Radiological success was achieved for 145 patients (80%), that is, 88% of plastic multistenting, 88% of self-expandable metal stenting and 61% of single stenting (P < 0.001 vs plastic multistenting; P < 0.05 vs self-expandable metal stenting). After first-line endo-therapy failure, the patients underwent a second-line endo-therapy with plastic multistenting for 25%, fully covered self-expandable metal stenting for 53% and single stenting for 22% of cases, and radiological success was achieved for 84%, that is, 100%, 85% and 63% with plastic multistenting, self-expandable metal stenting and single stenting (P < 0.05 vs plastic multistenting or self-expandable metal stenting) respectively. Procedure-related complications occurred in 7.8% of endoscopic retrograde cholangiopancreatographies. Overall, clinical success was achieved in 87% of patients after a median follow-up of 25 months. Conclusion: Plastic multistenting is confirmed as the preferred first-line treatment, while fully covered self-expandable metal stenting as rescue option for biliary anastomotic strictures. Single stenting has sub-optimal results and should be abandoned.

Published
2019

9. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Marmo, Riccardo, primary, Soncini, Marco, additional, Bucci, Cristina, additional, Zullo, Angelo, additional, Amitrano, L, additional, Anderloni, A, additional, Andriulli, A, additional, Annese, V, additional, Baldassarre, G, additional, Bargiggia, S, additional, Bazzoli, F, additional, Bennato, R, additional, Bianco, MA, additional, Bizzotto, A, additional, Boarino, V, additional, Bonanomi, AG, additional, Borgheresi, P, additional, Bresci, G, additional, Buffoli, F, additional, Buscarini, E, additional, Castrignanò, G, additional, Cavallaro, LG, additional, Cesaro, P, additional, Chirico, A, additional, Cipolletta, F, additional, Cipolletta, L, additional, Conigliaro, R, additional, Conte, D, additional, Costamagna, G, additional, Covello, F, additional, D'Amico, G, additional, De-Fanis, C, additional, De-Filippo, FR, additional, de-Franchis, R, additional, Dell‘Era, A, additional, De Nigris, F, additional, De-Matthaeis, M, additional, Di-Giorgio, P, additional, Di-Giulio, E, additional, Esposito, P, additional, Ferraris, L, additional, Filippino, A, additional, Franceschi, M, additional, Furio, L, additional, Germana', B, additional, Grassia, R, additional, Imperiali, G, additional, Lamanda, R, additional, Lauri, A, additional, Londoni, C, additional, Mangiafico, S, additional, Manno, M, additional, Marmo, C, additional, Merighi, A, additional, Meroni, R., additional, Metrangolo, S, additional, Montalbano, LM, additional, Napolitano, G, additional, Nucci, A, additional, Orsini, L, additional, Parente, F, additional, Parravicini, M, additional, Paterlini, A, additional, Pumpo, R, additional, Purita, L, additional, Repici, A, additional, Riccioni, ME, additional, Russo, A, additional, Segato, S, additional, Sorrentino, I, additional, Spinzi, G, additional, Spotti, D, additional, Tortora, A, additional, Tomba, C, additional, Triossi, O, additional, Zagari, RM, additional, and Zambelli, A, additional

Published
2021
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11. T01.01.7 THE USE OF A SPECIALIZED BLEEDING-MANAGEMENT TEAM HAD NO IMPACT ON MORTALITY FOR ACUTE UPPER GASTROINTESTINAL BLEEDING: AN ITALIAN PROSPECTIVE MULTICENTER COHORT STUDY

Author

Marmo, R., primary, Soncini, M., additional, Marmo, C., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2020
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12. OC.10.1 THE USE OF PRE-ENDOSCOPIC INTRAVENOUS PROTON PUMP INHIBITORS (PPIS) HAD NO IMPACT ON CLINICAL OUTCOMES IN ACUTE UPPER GASTROINTESTINAL BLEEDING: A PROSPECTIVE MULTICENTER ITALIAN COHORT STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2020
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14. OC.11.5 TRIGGER AND TARGET TRANSFUSION STRATEGY IN PATIENTS WITH NON-VARICEAL ACUTE UPPER GASTROINTESTINAL BLEEDING (NV-AUGIB): A PROSPECTIVE MULTICENTRE OBSERVATIONAL STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Spada, C., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2019
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15. OC.14.2 PREDICTIVE FACTORS OF MORTALITY IN ACUTE GASTROINTESTINAL BLEEDING IN ITALY (AUGIB): A NEW PRE-ENDOSCOPY PROGNOSTIC MODEL FROM A MULTICENTER STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Eera, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2018
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16. Low risk of colon cancer in patients with celiac disease

Author

Volta, Umberto, Vincentini, Olimpia, Quintarelli, Federica, Felli, Cristina, Silano, Marco, Gasbarrini, G, De Vitis, V, Santini, D, Scaggiante, F, Castellano, E, Grosso, S, Campanella, J, Corazza, GR, Sandri, G, Giorgetti, G, Caio, G, Lo Perfido, S, Perri F, Festa V, Pelli MA, Cavalletti ML, Segato S, Curzio M, Pennazio M, Rossini FP, Picarelli A, Pera A, Ercole E, Passaleva MT, Barbato M, Usai P, Dore MF, Chilovi F, Piazzi L, Zancanella L, Boarino V, Ferrari A., GRECO, LUIGI, AURICCHIO, SALVATORE, Volta, Umberto, Vincentini, Olimpia, Quintarelli, Federica, Felli, Cristina, Silano, Marco, Gasbarrini, G, De Vitis, V, Greco, Luigi, Auricchio, Salvatore, Santini, D, Scaggiante, F, Castellano, E, Grosso, S, Campanella, J, Corazza, Gr, Sandri, G, Giorgetti, G, Caio, G, Lo, Perfido, S, Perri, F, Festa, V, Pelli, Ma, Cavalletti, Ml, Segato, S, Curzio, M, Pennazio, M, Rossini, Fp, Picarelli, A, Pera, A, Ercole, E, Passaleva, Mt, Barbato, M, Usai, P, Dore, Mf, Chilovi, F, Piazzi, L, Zancanella, L, Boarino, V, Ferrari, A., Volta U, Vincentini O, Quintarelli F, Felli C, Silano M, and Collaborating Centres of the Italian Registry of the Complications of Celiac Disease

Subjects
Male, Colorectal cancer, COLON CANCER, Disease, Gastroenterology, Colon carcinoma, Retrospective Studie, Medicine, Child, Colonic Neoplasm, education.field_of_study, Medicine (all), Incidence, Celiac disease, Gluten-free diet, Adolescent, Adult, Carcinoma, Celiac Disease, Child, Preschool, Colonic Neoplasms, Diet, Gluten-Free, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Italy, Middle Aged, Patient Compliance, Retrospective Studies, Risk Assessment, Young Adult, Population study, Human, Cohort study, medicine.medical_specialty, Population, Follow-Up Studie, NO, Internal medicine, In patient, Preschool, education, business.industry, Newborn, medicine.disease, digestive system diseases, Diet, Standardized mortality ratio, Gluten-Free, Celiac disease, colon carcinoma, gluten-free diet, business
Abstract

Objective. Celiac disease (CD) has strongly been established as associated with some site-specific gastrointestinal malignancies. On the contrary, according to the few reports available, the risk of colon carcinoma in CD patients has been described similar to that of general population. In this cohort study, we describe the risk of colon carcinoma in a group of Italian celiac patients. Materials and methods. The study population included all CD patients diagnosed at the Collaborating Centers of the Italian Registry of CD between 1st January 1982 and 31st December 2006. Upon diagnosis of CD and upon at every subsequent clinical control, the Collaborating Centers filled in a validated form for each CD patient reporting information about demographic data, possible occurrence of a neoplasm and adherence to a gluten-free diet. Results. Out of 1757 celiac patients enrolled, 6 developed a colon carcinoma during the follow-up period (mean: 18.1 years). The standardized incidence ratio (SIR) resulted 0.29 (95% CI = 0.07–0.45). Stratifying the risk for the dietary gluten intake, the SIR dropped to 0.07 (95% CI = 0.009–0.27) for CD patients with a strict adherence to a gluten-free diet. Conclusion. We confirm the previous finding that there is low risk to develop a colon cancer in celiac patients.

Published
2014

17. P.10.8: Mortality from Acute Upper Gastrointestinal Bleeding (UGIB): The Role of the Organizational and Health Care Course: A Prospective Multicentre Observational Study in Italy

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, F., additional, Orsini, L., additional, Bennato, R., additional, Guardascione, M., additional, Parente, F., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Zingone, F., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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18. P.10.1: Transfusion Strategy and Death Risk in Patients with Acute Non-Variceal Upper Gastro Intestinal Bleeding (NV-UGIB) in Italy: A Prospective Multicenter Observational Study

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Mastrangelo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Zingone, F., additional, Lamanda, R., additional, Lauri, R., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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20. P.10.3: Mortality in Upper Gastrointestinal Bleeding in Italy: Data from National Survey

Author

Soncini, M., primary, Marmo, R., additional, Conte, D., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Tomba, C., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, and Balzano, A., additional

Published
2017
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21. P.10.10: Mortality Causes from Acute Upper Gastrointestinal Bleeding: A Prospective Multicentre Observational Study

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Guardascione, M., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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22. P.10.9: Outpatient Management of Patients with Glasgow-Blatchford Bleeding Score Low-Risk Upper-Gastrointestinal Hemorrhage: A Multicenter Validation Study in Italy

Author

Marmo, R., primary, Soncini, M., additional, Orsini, L., additional, Cipolletta, F., additional, Bennato, R., additional, Guardascione, M., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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23. OC.11.5: Endotherapies for Duct-To-Duct Biliary Anastomotic Stricture after Liver Transplantation (Basalt Study Group): Interim Analysis and Medium-Term Outcomes of a Retrospective Nationwide Italian Survey

Author

Cantù, P., primary, Parzanese, I., additional, Rosa, R., additional, Barbaro, F., additional, Forti, E., additional, Lombardi, G., additional, Nadal, E., additional, Boarino, V., additional, Pisani, A., additional, Di Sario, A., additional, Bertani, H., additional, Bulajic, M., additional, Ghinolfi, D., additional, Tringali, A., additional, Costamagna, G., additional, Mutignani, M., additional, Fantin, A., additional, Merighi, A., additional, Traini, S., additional, Conigliaro, R., additional, Zilli, M., additional, Filipponi, F., additional, Donato, M.F., additional, Maggi, U., additional, Caccamo, L., additional, Paone, G., additional, Reggiani, P., additional, Rossi, G., additional, Conte, D., additional, and Penagini, R., additional

Published
2017
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25. Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease

Author

Silano, Marco, Volta, Umberto, Vincenzi, Alessandro De, Dessì, Mariarita, Vincenzi, Massimo De, Gasbarrini, G., De Vitis, V., Santini, D., F. , Scaggiante M., Vincenzi, M., Federici, Null, Castellano, E., Calvi, A., Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Volta, U., Parisi, C., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, A., Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., Ferrari, A., GRECO, LUIGI, AURICCHIO, SALVATORE, Silano, Marco, Volta, Umberto, Vincenzi, Alessandro De, Dessì, Mariarita, Vincenzi, Massimo De, Gasbarrini, G., De Vitis, V., Greco, Luigi, Auricchio, Salvatore, Santini, D., F., Scaggiante M., Vincenzi, M., Federici, Null, Castellano, E., Calvi, A., Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Volta, U., Parisi, C., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, A., Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., and Ferrari, A.

Subjects
Male, Time Factors, Lymphoma, Physiology, Gastroenterology, Coeliac disease, Celiac disease, Enteropathy-associated T-cell lymphoma, Gluten-free diet, Child, chemistry.chemical_classification, Settore BIO/12, Middle Aged, Child, Preschool, Gluten-free diet, Enteropathy-associated T-cell lymphoma, Female, Human, Adult, medicine.medical_specialty, Intestinal Neoplasm, Glutens, Adolescent, Time Factor, Diet therapy, Malignancy, Lymphoma, T-Cell, Follow-Up Studie, Celiac disease, Celiac Disease, Follow-Up Studies, Humans, Infant, Intestinal Neoplasms, Patient Compliance, Stomach Neoplasms, Stomach Neoplasm, Internal medicine, medicine, Risk factor, Preschool, business.industry, nutritional and metabolic diseases, medicine.disease, T-Cell, Gluten, digestive system diseases, chemistry, Gluten free, business
Abstract

Patients with celiac disease have an increased rate of enteropathy-associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy. We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma. Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9-12.2; P < 0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac disease and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02-0.88; P < 0.001). The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X(2 )= 4.8 P = 0.01). These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.

Published
2008

26. Delayed diagnosis of coeliac disease increases cancer risk

Author

Silano, Marco, Volta, Umberto, Mecchia, Anna, Dessì, Mariarita, Di Benedetto, Rita, De Vincenzi, Massimo, Gasbarrini, G., De Vitis, D., Greco, L., Auricchio, S., Santini, D., Scaggiante, F., Federici, M. D., Castellano, E., Sategna-Guidetti, Null, Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Amici, Monica, De Franceschi, L., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, A., Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., Ferrari, A., Silano, Marco, Volta, Umberto, Mecchia, Anna, Dessì, Mariarita, Di Benedetto, Rita, De Vincenzi, Massimo, Gasbarrini, G., De Vitis, D., Greco, Luigi, Auricchio, Salvatore, Santini, D., Scaggiante, F., Federici, M. D., Castellano, E., Sategna Guidetti, Null, Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Amici, Monica, De Franceschi, L., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, A., Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., and Ferrari, A.

Subjects
Registrie, tumors, Adult, Male, Risk, medicine.medical_specialty, Time Factors, Time Factor, Delayed diagnosis, Gastroenterology, Coeliac disease, Internal medicine, Neoplasms, medicine, Neoplasm, Humans, Age Factor, In patient, Registries, lcsh:RC799-869, Coeliac disease, neoplasm, tumors, Age Factors, Celiac Disease, Female, Middle Aged, business.industry, Medicine (all), Settore BIO/12, Cancer, General Medicine, Hepatology, medicine.disease, Population study, lcsh:Diseases of the digestive system. Gastroenterology, Cancer risk, business, neoplasm, Human, Research Article
Abstract

Background The association between coeliac disease (CD) and neoplasms has been long established, but few data are available about the risk factors. The aim of this paper is to estimate the risk of developing a neoplasm among non diagnosed coeliac patients and to evaluate if this risk correlates with the age of patients at diagnosis of coeliac disease. Methods The study population consists of patients (n = 1968) diagnosed with CD at 20 Italian gastroenterology referral Centers between 1st January 1982 and 31st March 2005. Results The SIR for all cancers resulted to be 1.3; 95% CI = 1.0–1.7 p < 0.001. The specific SIRs for non Hodgkin lymphoma was 4.7; 95% CI = 2.9–7.3 p < 0.001, for the small bowel carcinoma 25; 95% CI = 8.5–51.4 p < 0.001, for non Hodgkin lymphoma 10; 95% CI = 2.7–25 p = 0.01, finally for the stomach carcinoma 3; 95% CI = 1.3–4.9 p < 0.08. The mean age at diagnosis of CD of patients that developed sooner or later a neoplasm was 47,6 ± 10.2 years versus 28.6 ± 18.2 years of patients who did not. Conclusion Coeliac patients have an increased risk of developing cancer in relation to the age of diagnosis of CD. This risk results higher for malignancies of the gastro-intestinal sites. An accurate screening for tumors should be performed in patients diagnosed with CD in adulthood and in advancing age.

Published
2007

27. P.15.8 POOR OUTCOME FROM ACUTE UPPER GASTROINTESTINAL BLEEDING IN PATIENTS WITH LIVER CIRRHOSIS: A PROSPECTIVE MULTICENTER OBSERVATIONAL STUDY

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, L., additional, Parente, F., additional, Paterlini, A., additional, Orsini, L., additional, Guardascione, M., additional, Amitrano, L., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Dell'Era, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Spinzi, G., additional, Imperiali, G., additional, Maringhi, A., additional, Boarino, V., additional, Bresci, G., additional, Metrangolo, S., additional, Bucci, C., additional, Baldassarre, G., additional, Gasparini, P., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Masci, E., additional, Marin, R., additional, Antoniazzi, S., additional, Ferraris, L., additional, Repici, A., additional, Andreloni, A., additional, Bianco, M.A., additional, Rotondano, G., additional, De Matthaeis, M., additional, Lauri, A., additional, De Fanis, C., additional, Borgheresi, P., additional, De Stefano, S., additional, Lamanda, R., additional, Furio, L., additional, Russo, A., additional, Maringhini, A., additional, Politi, F., additional, Di Giorgio, P., additional, Pumpo, R., additional, Martorano, M., additional, Triossi, O., additional, Coccia, G., additional, Montalbano, L.M., additional, Zagari, R.M., additional, Balzano, A., additional, Buscarini, E., additional, Conte, D., additional, D'Amico, G., additional, Di Giulio, E., additional, and De Franchis, R., additional

Published
2016
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28. P.15.9 TRANSFUSION STRATEGY AND DEATH RISK IN PATIENTS WITH ACUTE NON VARICEAL UPPER GASTRO INTESTINAL BLEEDING (NV-UGIB) IN ITALY: A PROSPECTIVE MULTICENTER OBSERVATIONAL STUDY

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, L., additional, Parente, F., additional, Paterlini, A., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Dell'Era, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Spinzi, G., additional, Imperiali, G., additional, Maringhi, A., additional, Boarino, V., additional, Bresci, G., additional, Metrangolo, S., additional, Bucci, C., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Masci, E., additional, Marin, R., additional, Antoniazzi, S., additional, Ferraris, L., additional, Repici, A., additional, Andreloni, A., additional, Bianco, M.A., additional, Rotondano, G., additional, De Matthaeis, M., additional, Lauri, A., additional, De Fanis, C., additional, Borgheresi, P., additional, De Stefano, S., additional, Lamanda, R., additional, Furio, L., additional, Russo, A., additional, Di Giorgio, P., additional, Politi, F., additional, Pumpo, R., additional, Triossi, O., additional, Coccia, G., additional, Montalbano, L.M., additional, Zagari, R.M., additional, Balzano, A., additional, Buscarini, E., additional, Conte, D., additional, D'Amico, G., additional, Di Giulio, E., additional, Gasparini, P., additional, and De Franchis, R., additional

Published
2016
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29. PC.01.1 MANAGEMENT OF BILIARY ANASTOMOTIC STRICTURE AFTER LIVER TRANSPLANTATION (BASALT STUDY): RESULTS OF A NATIONAL SURVEY IN ITALY

Author

Cantù, P., primary, Parzanese, I., additional, Balassone, V., additional, Di Sario, A., additional, Soggiu, F., additional, Lombardi, G., additional, Barbaro, F., additional, Pisani, A., additional, Baldan, A., additional, Cariani, G., additional, Boarino, V., additional, Fasoli, A., additional, Bertani, H., additional, Forti, E., additional, Bulajic, M., additional, Ghinolfi, D., additional, Nadal, E., additional, Cerofolini, A., additional, Barresi, L., additional, Stroppa, I., additional, Mazzaferro, V., additional, Cipolletta, L., additional, Tringali, A., additional, Costamagna, G., additional, Ravelli, P., additional, Bazzoli, F., additional, Merighi, A., additional, Parodi, M.C., additional, Conigliaro, R., additional, Mutignani, M., additional, Zilli, M., additional, Filipponi, F., additional, Fantin, A., additional, Rodella, L., additional, Traina, M., additional, Rotondano, G., additional, Rosa, R., additional, Malinverno, F., additional, Donato, F., additional, Colombo, M., additional, Conte, D., additional, Rossi, G., additional, and Penagini, R., additional

Published
2016
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31. P.15.3 INCREASED PERFORMANCE OF AN UPDATED ROCKALL SCORE IN ACUTE NON VARICEAL UPPER GASTRO INTESTINAL BLEEDING: A PROSPECTIVE MULTICENTRE ITALIAN STUDY

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, L., additional, Parente, F., additional, Paterlini, A., additional, Bennato, R., additional, Cipolletta, F., additional, Amitrano, L., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Dell'Era, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Spinzi, G., additional, Imperiali, G., additional, Merighi, A., additional, Boarino, V., additional, Bresci, G., additional, Metrangolo, S., additional, Bucci, C., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Masci, E., additional, Marin, R., additional, Antoniazzi, S., additional, Ferraris, L., additional, Repici, A., additional, Andreloni, A., additional, Bianco, M.A., additional, De Matthaeis, M., additional, Lauri, A., additional, De Fanis, C., additional, Borgheresi, P., additional, De Stefano, S., additional, Lamanda, R., additional, Furio, L., additional, Russo, A., additional, Maringhini, A., additional, Politi, F., additional, Di Giorgio, P., additional, Pumpo, R., additional, Martorano, M., additional, Triossi, O., additional, Coccia, G., additional, Montalbano, L.M., additional, Zagari, R.M., additional, Buscarini, E., additional, Conte, D., additional, D'Amico, G., additional, Di Giulio, E., additional, Balzano, A., additional, Gasparini, P., additional, Rotondano, G., additional, and De Franchis, R., additional

Published
2016
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32. Clinical features of chronic C virus hepatitis in patients with celiac disease

Author

Silano, M., Volta, U., Vincentini, O., De Vincenzi, M., Gasbarrini Italian Registry Of The Complications Of Celiac Disease, (., De Vitis, V., Greco, L., Auricchio, S., Santini, D., Scaggiante, F., Vincenzi, M., Federici, Castellano, E., Calvi, A., Sategna, Guidetti, Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Amici, M., Parisi, C., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, Antonio, Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., and Ferrari, A.

Subjects
Microbiology (medical), Adult, Male, medicine.medical_specialty, Hepatitis C virus, Population, Autoimmune hepatitis, medicine.disease_cause, Gastroenterology, Antiviral Agents, Coeliac disease, Primary sclerosing cholangitis, Primary biliary cirrhosis, Internal medicine, medicine, Prevalence, Humans, education, Hepatitis, education.field_of_study, Anemia, Iron-Deficiency, business.industry, Depression, General Medicine, Hepatitis C, Hepatitis C, Chronic, medicine.disease, Arthralgia, digestive system diseases, Celiac Disease, Infectious Diseases, Diabetes Mellitus, Type 2, Immunology, Female, business
Abstract

The association between celiac disease (CD) and several liver disorders has long been documented. About 40% of adult celiac patients have been reported to have mild to moderate hypertransaminasemia (up to five times the upper limit of normal) at the time of diagnosis of CD [1, 2]. In addition, CD has been found in roughly 10% of patients with unexplained hypertransaminasemia, and the majority of them have had their liver enzyme levels normalized after one year of following a strict gluten-free diet [3, 4]. In addition, an increased prevalence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis among CD patients has been reported [5, 6]. CD might also be linked to very severe liver conditions such as end-stage liver failure and hepatocellular carcinoma [7]. There is also evidence, even contrasting reports, about the association of CD with nonalcoholic steatohepatitis and fatty liver disease [8]. In contrast, no definitive evidence is available about the association between chronic hepatitis C (hepatitis C virus [HCV]) and CD. Fine et al. described a three-fold increase of CD prevalence among HCV patients compared to noninfected celiac individuals [9]. It has also been reported the activation of silent CD during the antiviral treatment for HCV with interferon-α and ribavirin, both alone and in combination [10]. Consequently, a routine serological screening for CD has been proposed in HCV patients before starting antiviral therapy. In case of HCV positivity, the achievement of the histological normalization of the intestinal mucosa after following a gluten-free diet has been advised before starting the therapy [10]. On the contrary, some recent prospective studies have not shown increased prevalence of CD among HCV patients and reported that the link between these two conditions is biased by the route of transmission [11, 12]. Among the 3,725 celiac patients included in the Italian Registry of the Complication of Celiac Disease, we identified 34 individuals (0.91%) that had an HCV chronic hepatitis at the time of diagnosis of CD. For the diagnosis of HCV, we considered the serological positivity of antiHCV antibodies. Some of the patients had the diagnosis made in the early 1980s, when the molecular tests for the detection of the viral antigens were not yet available. The demographic and clinical features of the patients with both CD and HCV with respect to those of patients with CD only are listed in Table 1. The prevalence of HCV among our celiac series is lower than the overall prevalence of HCV among the general population in Italy, matched for age and gender, which is estimated to be around 2% [13]. This finding does not support the hypothesis of a potential correlation between these two disorders. It has been assumed that antiviral therapy with INF-α and ribavirin may precipitate the onset of CD in susceptible individuals, promoting a Th1-specific response in the small intestine [14]. However, in our series, only 12 of the 34 celiac patients with HCV had antiviral therapy before CD diagnosis. Looking at our series, it seems more likely that an overall increased risk of CD in HCV patients exists, due to the predisposition for autoimmune diseases related to Eur J Clin Microbiol Infect Dis (2009) 28:1267–1269 DOI 10.1007/s10096-009-0769-6

Published
2009

43. The 'Hub and Spoke' model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Cristina Bucci, L. Amitrano, C. Londoni, A. Chirico, O. Triossi, A. Zambelli, F. Bazzoli, B. Germanà, F. Cipolletta, Marco Soncini, S. Mangiafico, F. Parente, E Di-Giulio, A. Andriulli, G. D'Amico, G. Baldassarre, Riccardo Marmo, A. Repici, A. Paterlini, G. Imperiali, Angelo Zullo, V Annese, F. De Nigris, R. Bennato, S. Metrangolo, L. Orsini, S. Bargiggia, I Sorrentino, M. Manno, Maria Elena Riccioni, C. Tomba, A. Nucci, A. Bizzotto, FR De-Filippo, A. Merighi, Guido Costamagna, R de-Franchis, C. Marmo, A. Anderloni, L.G. Cavallaro, P Esposito, A. Russo, R. Pumpo, D. Conte, M.A. Bianco, F Buffoli, L. Cipolletta, R. Conigliaro, P Di-Giorgio, A Filippino, G. Bresci, F Covello, P. Borgheresi, L.M. Montalbano, R.M. Zagari, E. Buscarini, Annalisa Tortora, D. Spotti, L. Ferraris, R. Lamanda, M. Franceschi, G Castrignanò, G. Spinzi, A. Lauri, S. Segato, R Grassia, V. Boarino, P. Cesaro, C De-Fanis, R. Meroni, G. Napolitano, L. Furio, AG Bonanomi, M De-Matthaeis, M. Parravicini, A Dell‘Era, L. Purita, Marmo R., Soncini M., Bucci C., Zullo A., Amitrano L., Anderloni A., Andriulli A., Annese V., Baldassarre G., Bargiggia S., Bazzoli F., Bennato R., Bianco M.A., Bizzotto A., Boarino V., Bonanomi A.G., Borgheresi P., Bresci G., Buffoli F., Buscarini E., Castrignano G., Cavallaro L.G., Cesaro P., Chirico A., Cipolletta F., Cipolletta L., Conigliaro R., Conte D., Costamagna G., Covello F., D'Amico G., De-Fanis C., De-Filippo F.R., de-Franchis R., Dell'Era A., De Nigris F., De-Matthaeis M., Di-Giorgio P., Di-Giulio E., Esposito P., Ferraris L., Filippino A., Franceschi M., Furio L., Germana' B., Grassia R., Imperiali G., Lamanda R., Lauri A., Londoni C., Mangiafico S., Manno M., Marmo C., Merighi A., Meroni R., Metrangolo S., Montalbano L.M., Napolitano G., Nucci A., Orsini L., Parente F., Parravicini M., Paterlini A., Pumpo R., Purita L., Repici A., Riccioni M.E., Russo A., Segato S., Sorrentino I., Spinzi G., Spotti D., Tortora A., Tomba C., Triossi O., Zagari R.M., and Zambelli A.

Subjects
medicine.medical_specialty, Gastrointestinal bleeding, Multivariate analysis, Organizational model, Improved survival, Comorbidity, 03 medical and health sciences, Organizational setting, 0302 clinical medicine, Health care, Spoke-hub distribution paradigm, Medicine, Humans, Hub and spoke network, Mortality, Aged, Hepatology, business.industry, Delivery of Health Care, Integrated, Gastroenterology, Acute upper gastrointestinal bleeding, Length of Stay, Middle Aged, medicine.disease, Italy, 030220 oncology & carcinogenesis, Case-Control Studies, Emergency medicine, 030211 gastroenterology & hepatology, business, Gastrointestinal Hemorrhage, Acute gastrointestinal bleeding, Cohort study
Abstract

Background: the lack of standardized pathways for patients with gastrointestinal bleeding may have led to differences in their management and inequity to medical care access. The "Hub & Spoke" model was adopted to fill this gap in many disciplines, but, to our knowledge, no data exist on its efficacy on mortality in GI bleeding. We aimed to evaluate if the "Hub & Spoke" organizational model has an impact on mortality risk from UGIB. Methods: from January 2014 to December 2015, 3324 consecutive patients admitted for UGIB in 50 Italian hospitals were enrolled (1977 patients in hospitals within the "Hub & Spoke" network for digestive hemorrhagic emergency and 1347 in hospitals outside the "Hub & Spoke" network). Clinical, endoscopic and organizational data were recorded. Results: we observed no differences in mortality between patients admitted to hospitals included or not included in the "Hub & Spoke" network (5.2% vs 6.1%, p = 0.3). On multivariate analysis, admission in gastroenterology wards (OR 0.61, p = 0.001) or an academic hospital (OR 0.65, p < 0.056) were independent protective factors while being in "Hub & Spoke" organization system did not affect mortality (OR 1.09, p = 0.57). Conclusion: the "Hub & Spoke" model per sé does not impact on mortality while being treated in academic hospital or gastroenterology wards improved survival.

Published
2021

44. Endo-therapies for biliary duct-to-duct anastomotic stricture after liver transplantation: Outcomes of a nationwide survey

Author

Paolo Ravelli, A. Cerofolini, Helga Bertani, Milutin Bulajic, Vincenzo Mazzaferro, Mario Traina, Paolo Cantù, Alberto Fantin, Ilaria Tarantino, Massimiliano Mutignani, Davide Ghinolfi, Luca Barresi, Rita Conigliaro, T. Staiano, Pietro Lampertico, R. Rosa, Luca Rodella, Antonio Pisani, Roberto Penagini, Giovanni Lombardi, Giorgia Catalano, M. Monteleone, Alberto Merighi, Luca Maroni, Umberto Maggi, Luciano De Carlis, Guido Costamagna, Enzo Masci, Dario Ligresti, A. Baldan, Lucio Caccamo, E. Zucchi, E. Nadal, Maurizio Zilli, Edoardo Forti, I. Parzanese, Maurizio Vecchi, Franco Filipponi, Andrea Tringali, Mauro Salizzoni, Maria Francesca Donato, V. Boarino, Giulio Santi, Giorgio Rossi, Federico Barbaro, Antonio Di Sario, Cantu, P, Tarantino, I, Baldan, A, Mutignani, M, Tringali, A, Lombardi, G, Cerofolini, A, Di Sario, A, Catalano, G, Bertani, H, Ghinolfi, D, Boarino, V, Masci, E, Bulajic, M, Pisani, A, Fantin, A, Ligresti, D, Barresi, L, Traina, M, Ravelli, P, Forti, E, Barbaro, F, Costamagna, G, Rodella, L, Maroni, L, Salizzoni, M, Conigliaro, R, Filipponi, F, Merighi, A, Staiano, T, Monteleone, M, Mazzaferro, V, Zucchi, E, Zilli, M, Nadal, E, Rosa, R, Santi, G, Parzanese, I, De Carlis, L, Donato, M, Lampertico, P, Maggi, U, Caccamo, L, Rossi, G, Vecchi, M, and Penagini, R

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Biliary Tract Diseases, Self Expandable Metallic Stents, Constriction, Pathologic, Anastomosis, Liver transplantation, Nationwide survey, Clinical success, Young Adult, ERCP, Surveys and Questionnaires, Medicine, Humans, biliary anastomotic stricture, Aged, Retrospective Studies, Cholangiopancreatography, Endoscopic Retrograde, Cholestasis, Hepatology, medicine.diagnostic_test, liver transplantation, business.industry, Middle Aged, equipment and supplies, Survival Analysis, Surgery, Endoscopy, fully covered metal stenting, medicine.anatomical_structure, Treatment Outcome, Italy, Radiological weapon, Female, Stents, business, Duct (anatomy), Plastics, plastic multistenting
Abstract

Background: The most appropriate endo-therapeutic approach to biliary anastomotic strictures is yet to be defined. Aim: To retrospectively report on the endo-therapy of duct-to-duct anastomotic strictures during 2013 in Italy. Methods: Data were collected from 16 Endoscopy Units at the Italian Liver Transplantation Centers (BASALT study group). Results: Complete endo-therapy and follow-up data are available for 181 patients: 101 treated with plastic multistenting, 26 with fully covered self-expandable metal stenting and 54 with single stenting. Radiological success was achieved for 145 patients (80%), that is, 88% of plastic multistenting, 88% of self-expandable metal stenting and 61% of single stenting (P

Published
2019

45. Asparaginase-associated Pancreatitis Complicated by Pancreatic Fluid Collection Treated with Endoscopic Cistogastrostomy in Pediatric Acute Lymphoblastic Leukemia: A Case Report and Systematic Review of the Literature.

Author

Fiumana G, Pancaldi A, Bertani H, Boarino V, Cellini M, and Iughetti L

Abstract

Asparaginase-associated pancreatitis complicates 2-10% of patients treated for acute lymphoblastic leukemia, causing morbidity and discontinuation of asparaginase administration. Among acute complications, pancreatic fluid collections can be managed conservatively, but intervention is indicated when associated with persistent insulin therapy need and recurrent abdominal pain. Endoscopic treatment has become the standard approach in adult patients, with increasing favorable evidence in children. This work compares the characteristics of a pediatric oncology patient treated at our institution with reported literature experiences, showing feasibility, safety and effectiveness of endoscopic approach., Competing Interests: The authors have no conflict of interest or funding to declare.

Published
2023
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46. The management of endoscopic retrograde cholangio- pancreatography-related infections risk: results of an italian survey at regional level.

Author

Cennamo V, Landi S, Aragona G, Colecchia A, Conigliaro R, Di Lorenzo D, Di Marco M, Fabbri C, Falcone P, Gaiani F, Manno M, Merighi A, Mussetto A, Peghetti A, Sassateli R, Solfrini V, Zagari RM, Arena R, Bertani H, Binda C, Boarino V, De Padova A, Feletti V, Fuccio L, Iori V, Nervi G, Prati GM, Soriani P, and De Palma R

Subjects
Humans, Surveys and Questionnaires, Drug Resistance, Multiple, Bacterial, Italy epidemiology, Cholangiopancreatography, Endoscopic Retrograde adverse effects, Duodenoscopes microbiology
Abstract

Background and Aim: Among the Endoscopic retrograde cholangiopancreatography (ERCP) adverse events, an increasingly arising problem is the transmission of Multi Drug Resistant (MDR) Bacteria through duodenoscopes. The aim of this survey was to evaluate the current clinical practice of management of ERCP associated infections in Emilia-Romagna, Italy., Methods: An online survey was developed including 12 questions on management of ERCP associated infections risk. The survey was proposed to all 12 endoscopy centers in Emilia Romagna that perform at least &gt; 200 ERCPs per year., Results: 11 centers completed the survey (92%). Among all risk factors of ERCP infections, hospitalization in intensive care units, immunosuppressant therapies, and previous MDR infections have achieved a 80 % minimum of concurrence by our respondents. The majority of them did not have a formalized document in their hospital describing categories and risk factors helpful in the detection of patients undergoing ERCP with an high-level infective risk (9/11, 82%). Most centers (8/11, 72%) do not perform screening in patients at risk of ERCP infections. Post procedural monitoring is performed by 6 of 11 centers (55%)., Conclusion: Our survey showed that, at least at regional level, there is a lack of procedures and protocols related to the management of patients at risk of ERCP infections.

Published
2023
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47. Preliminary results of a multidisciplinary Italian study adopting a Psycho-Neuro-Endocrine-Immunological (PNEI) approach to the study of colorectal adenomas.

Author

Mancini S, Alboni S, Mattei G, Rioli G, Sena P, Marchi M, Sacchetti A, Boarino V, Roncucci L, Galeazzi GM, and Ferrari S

Subjects
Aged, Anxiety epidemiology, Colonoscopy, Depression epidemiology, Female, Humans, Inflammation epidemiology, Italy epidemiology, Male, Metabolic Syndrome epidemiology, Middle Aged, Risk Factors, Adenoma epidemiology, Colorectal Neoplasms epidemiology
Abstract

Background and aim of the work Colorectal mucosal precancerous lesions, metabolic syndrome (MetS) and psychiatric disorders may share a common low-grade local and systemic inflammation. Aim is to report on preliminary data concerning a research adopting a psycho-neuro-endocrine-immune (PNEI) approach to study outpatients undergoing colonoscopy. Methods A sample of patients undergoing colonoscopy was cross-sectionally investigated. Data on colorectal adenomas, MetS, early atherosclerosis, anxious-depressive symptoms, personality traits, and inflammatory markers were statistically analyzed. Results Sixty-two patients were recruited (female 50%, mean age: 60.8±9.4 years). The prevalence of adenomas and MetS was respectively of 45.2% and 41.9%. Anxiety and depressive symptoms were detected in 16 (32.7%) and 9 (18.4%) subjects, respectively. The presence of adenomas positively correlated with male sex (p=0.01), age (p<0.01), IL-6 (p=0.03), hsCRP (p=0.04), and MetS (p=0.03); it was also associated with hsCRP concentration (aOR=3.81, p=0.03). Conclusions Proinflammatory atherogenic status, psychological traits, increased mucosal inflammation, and metabolic parameters may share a common a pathogenic mechanism, worth studying.

Published
2020
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48. Symptomatic response to GERDOFF® in patients with gastro-esophageal reflux disease and poor response to alginates: an exploratory, post-market, open-label study.

Author

Boarino V, Raguzzi I, Marocchi M, and Merighi A

Subjects
Adult, Aged, Clinical Trials as Topic, Drug Therapy, Combination, Female, Gastroesophageal Reflux complications, Heartburn drug therapy, Heartburn etiology, Humans, Male, Middle Aged, Patient Satisfaction, Pilot Projects, Product Surveillance, Postmarketing, Surveys and Questionnaires, Tablets, Treatment Outcome, Alginates administration & dosage, Antacids administration & dosage, Chondroitin Sulfates administration & dosage, Gastroesophageal Reflux drug therapy, Proton Pump Inhibitors administration & dosage
Abstract

Background/aims: A novel medical device based on hyaluronic acid, chondroitin sulphate plus aluminum hydroxide (GERDOFF®, melt-in-mouth tablets) showed efficacy in reducing GER-related symptoms. This exploratory, open-label study evaluated symptomatic effects of a 14-day treatment with GERDOFF® in GERD patients., Materials and Methods: GERD Impact Scale (GIS) questionnaire was filled at baseline visit, after 7 and 14 days of treatment; patients' Global Satisfaction was evaluated at the final visit. Primary endpoint was the reduction of heartburn episodes per week; secondary endpoints were GERD-related symptoms, patients' satisfaction, and safety., Results: Forty patients were included, 22 were on stable therapy with proton pump inhibitor (PPI). Compared to baseline, the days with heartburn episodes and the GIS score progressively decreased during the first (p<0.0001) and the second week of treatment (p<0.0001). Heartburn episodes per week (p<0.0001) and the GIS score (p<0.0001) decreased in the first and the last 7 days of 14-day treatment and did not differ between patients on and off PPI. The treatment was safe and well-tolerated, and it was rated as very good (46.2%) or good (43.6%) on the satisfaction questionnaire., Conclusion: GERDOFF® could effectively treat GER symptoms in patients not responding to PPI or alginate-based formulation. ISRCTN&#95;15143752.

Published
2020
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49. Endo-therapies for biliary duct-to-duct anastomotic stricture after liver transplantation: Outcomes of a nationwide survey.

Author

Cantù P, Tarantino I, Baldan A, Mutignani M, Tringali A, Lombardi G, Cerofolini A, Di Sario A, Catalano G, Bertani H, Ghinolfi D, Boarino V, Masci E, Bulajic M, Pisani A, Fantin A, Ligresti D, Barresi L, Traina M, Ravelli P, Forti E, Barbaro F, Costamagna G, Rodella L, Maroni L, Salizzoni M, Conigliaro R, Filipponi F, Merighi A, Staiano T, Monteleone M, Mazzaferro V, Zucchi E, Zilli M, Nadal E, Rosa R, Santi G, Parzanese I, De Carlis L, Donato MF, Lampertico P, Maggi U, Caccamo L, Rossi G, Vecchi M, and Penagini R

Subjects
Adult, Aged, Biliary Tract Diseases etiology, Biliary Tract Diseases surgery, Cholestasis etiology, Constriction, Pathologic etiology, Female, Humans, Italy, Liver Transplantation mortality, Male, Middle Aged, Plastics, Retrospective Studies, Surveys and Questionnaires, Survival Analysis, Treatment Outcome, Young Adult, Cholangiopancreatography, Endoscopic Retrograde instrumentation, Constriction, Pathologic surgery, Liver Transplantation adverse effects, Self Expandable Metallic Stents, Stents classification
Abstract

Background: The most appropriate endo-therapeutic approach to biliary anastomotic strictures is yet to be defined., Aim: To retrospectively report on the endo-therapy of duct-to-duct anastomotic strictures during 2013 in Italy., Methods: Data were collected from 16 Endoscopy Units at the Italian Liver Transplantation Centers (BASALT study group)., Results: Complete endo-therapy and follow-up data are available for 181 patients: 101 treated with plastic multistenting, 26 with fully covered self-expandable metal stenting and 54 with single stenting. Radiological success was achieved for 145 patients (80%), that is, 88% of plastic multistenting, 88% of self-expandable metal stenting and 61% of single stenting (P < 0.001 vs plastic multistenting; P < 0.05 vs self-expandable metal stenting). After first-line endo-therapy failure, the patients underwent a second-line endo-therapy with plastic multistenting for 25%, fully covered self-expandable metal stenting for 53% and single stenting for 22% of cases, and radiological success was achieved for 84%, that is, 100%, 85% and 63% with plastic multistenting, self-expandable metal stenting and single stenting (P < 0.05 vs plastic multistenting or self-expandable metal stenting) respectively. Procedure-related complications occurred in 7.8% of endoscopic retrograde cholangiopancreatographies. Overall, clinical success was achieved in 87% of patients after a median follow-up of 25 months., Conclusion: Plastic multistenting is confirmed as the preferred first-line treatment, while fully covered self-expandable metal stenting as rescue option for biliary anastomotic strictures. Single stenting has sub-optimal results and should be abandoned., (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2019
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50. A hyaluronic acid- and chondroitin sulfate-based medical device improves gastritis pain, discomfort, and endoscopic features.

Author

Iannitti T, Morales-Medina JC, Merighi A, Boarino V, Laurino C, Vadalà M, and Palmieri B

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Anecdotes as Topic, Child, Chondroitin Sulfates therapeutic use, Double Bind Interaction, Equipment and Supplies, Female, Gastritis complications, Gastritis diagnosis, Humans, Hyaluronic Acid therapeutic use, Male, Middle Aged, Pain etiology, Random Allocation, Retrospective Studies, Treatment Outcome, Young Adult, Chondroitin Sulfates administration & dosage, Endoscopy, Digestive System methods, Gastritis drug therapy, Hyaluronic Acid administration & dosage, Pain drug therapy
Abstract

Gastritis is an inflammation of the gastric mucosa. In this study, we investigated the efficacy of a medical device, Esoxx®, based on hyaluronic acid and chondroitin sulfate on gastritis-related upper abdominal pain/discomfort and endoscopic features. Fifty patients, affected by gastritis, were randomised to receive the medical device or placebo. The primary endpoint was the medical device efficacy on upper abdominal pain/discomfort associated with gastritis and measured by Visual Analogue Scale (VAS). The secondary endpoints were the efficacy of the medical device on gastritis-related mucosal erosions, blood oozing, and hyperemia (redness)/edema, as assessed by endoscopy, and the patients' rating of their compliance with the treatments. A significant reduction in VAS pain was observed in the treatment group after a 5-week treatment, if compared with placebo (p < 0.001). In summary, administration of a medical device, based on hyaluronic acid and chondroitin sulfate, improves gastritis-related upper abdominal pain/discomfort and decreases mucosal erosions, blood oozing, and hyperemia (redness)/edema at 5-week follow-up in patients affected by gastritis.

Published
2018
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