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16 results on '"Bocconi, Alessandro"'

2. Pembrolizumab in Vaginal Carcinoma: A Case Report and Review of the Literature.

Author

Vitale, Maria Giuseppa, Nasso, Cecilia, Riccò, Beatrice, Bocconi, Alessandro, Chiavelli, Chiara, Baldessari, Cinzia, Pipitone, Stefania, Bacchelli, Francesca, Botticelli, Laura, Dominici, Massimo, and Sabbatini, Roberto

Subjects
VAGINAL cancer, PEMBROLIZUMAB, CARCINOMA, GOVERNMENT aid, VULVAR cancer, GYNECOLOGIC cancer
Abstract

Introduction: Vaginal cancer is a rare gynecologic malignancy. While in a localized disease, concurrent chemoradiation grants local control and better overall survival, in a metastatic setting, the management options are very limited. Furthermore, recurrent cervical, vulvar, and vaginal carcinomas notoriously develop resistance to treatment, and consequently, their prognosis is still poor. Case Presentation: We herein present the case of a woman with a nodal relapse of vaginal carcinoma, effectively treated with third-line immunotherapy. We will also provide a review of the literature on the new therapeutic strategies for advanced vaginal carcinoma, with a focus on pembrolizumab immunotherapy. Conclusion: Pembrolizumab might represent a promising option for the management of vaginal and vulvar cancer, but data to support its use in this setting are still lacking. This case highlights the need for further investigation and trial designs for this rare disease. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Clinical Significance of Molecular Subtypes in Western Advanced Gastric Cancer: A Real-World Multicenter Experience

Author

Salati, Massimiliano, primary, Ghidini, Michele, additional, Paccagnella, Matteo, additional, Reggiani Bonetti, Luca, additional, Bocconi, Alessandro, additional, Spallanzani, Andrea, additional, Gelsomino, Fabio, additional, Barbin, Francesca, additional, Garrone, Ornella, additional, Daniele, Bruno, additional, Dominici, Massimo, additional, Facciorusso, Antonio, additional, and Petrillo, Angelica, additional

Published
2023
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4. When Affordances Climb into Your Mind: Advantages of Motor Simulation in a Memory Task Performed by Novice and Expert Rock Climbers

Author

Pezzulo, Giovanni, Barca, Laura, and Bocconi, Alessandro Lamberti

Abstract

Does the sight of multiple climbing holds laid along a path activate a motor simulation of climbing that path? One way of testing whether multiple affordances and their displacement influence the formation of a motor simulation is to study acquired motor skills. We used a behavioral task in which expert and novice rock climbers were shown three routes: an easy route, a route impossible to climb but perceptually salient, and a difficult route. After a distraction task, they were then given a recall test in which they had to write down the sequence of holds composing each route. We found no difference between experts and novices on the easy and impossible routes, whereas on the difficult route, the performance of experts was better than that of novices. This suggests that seeing a climbing wall activates a motor, embodied simulation, which relies not on perceptual salience, but on motor competence. More importantly, our results show that the capability to form this simulation is modulated by individuals' motor repertoire and expertise, and that this strongly impacts recall. (Contains 3 figures.)

Published
2010
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6. CtDNA-guided rechallenge with anti-EGFR therapy in RASwt metastatic colorectal cancer: Evidence from clinical practice

Author

D’Onofrio, Raffaella, primary, Caputo, Francesco, additional, Prampolini, Francesco, additional, Spallanzani, Andrea, additional, Gelsomino, Fabio, additional, Bettelli, Stefania, additional, Manfredini, Samantha, additional, Reggiani Bonetti, Luca, additional, Carotenuto, Pietro, additional, Bocconi, Alessandro, additional, Dominici, Massimo, additional, Luppi, Gabriele, additional, and Salati, Massimiliano, additional

Published
2022
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7. CtDNA-guided rechallenge with anti-EGFR therapy in RASwt metastatic colorectal cancer: Evidence from clinical practice

Author

D’Onofrio, Raffaella, Caputo, Francesco, Prampolini, Francesco, Spallanzani, Andrea, Gelsomino, Fabio, Bettelli, Stefania, Manfredini, Samantha, Reggiani Bonetti, Luca, Carotenuto, Pietro, Bocconi, Alessandro, Dominici, Massimo, Luppi, Gabriele, and Salati, Massimiliano

Abstract

Aim: To apply extended ctDNA-based RAS genotyping to clinical criteria for improving the selection of patients eligible for anti-EGFR-based rechallenge in a real-world setting.Methods: ctDNA testing was prospectively applied to RASwt mCRC progressed after a first-line anti-EGFR-containing regimen and at least one other line. The primary endpoint was the objective response rate.Results: Among ten enrolled patients, the anti-EGFR rechallenge resulted in an objective response rate and disease control rate of 70% and 90%. The median progression-free survival was 11.3 months and overall survival was not reached. Compared with a historical cohort retreated with anti-EGFR agents based on clinical criteria, the ctDNA-driven approach resulted in a higher chance of achieving an objective response and longer survival.Conclusions: Blood-based RASwt status may enrich metastatic colorectal cancer more likely to benefit from anti-EGFR-based rechallenge. RAS genotyping in ctDNA represents a feasible, fast, and cost-effective tool to be implemented in the clinic for advancing precision medicine.

Published
2023
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8. The Prognostic Role of Early Skeletal Muscle Mass Depletion in Multimodality Management of Patients with Advanced Gastric Cancer Treated with First Line Chemotherapy: A Pilot Experience from Modena Cancer Center

Author

Rimini, Margherita, primary, Pecchi, Annarita, additional, Prampolini, Francesco, additional, Bussei, Chiara, additional, Salati, Massimiliano, additional, Forni, Daniela, additional, Martelli, Francesca, additional, Valoriani, Filippo, additional, Canino, Fabio, additional, Bocconi, Alessandro, additional, Gelsomino, Fabio, additional, Reverberi, Linda, additional, Benatti, Stefania, additional, Piacentini, Federico, additional, Menozzi, Renata, additional, Dominici, Massimo, additional, Luppi, Gabriele, additional, and Spallanzani, Andrea, additional

Published
2021
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9. The immune checkpoint CD73 (NT5E) in gastric adenocarcinoma (GAC): Biological characterization and clinical implications.

Author

Salati, Massimiliano, primary, Spallanzani, Andrea, additional, Gelsomino, Fabio, additional, Botticelli, Andrea, additional, Cerbelli, Bruna, additional, Riggi, Laura, additional, Bocconi, Alessandro, additional, D'Onofrio, Raffaella, additional, Benatti, Stefania, additional, Luppi, Gabriele, additional, and Dominici, Massimo, additional

Published
2021
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10. Efficacy and Safety of Immune Checkpoint Inhibitors in Patients with Microsatellite Instability-High End-Stage Cancers and Poor Performance Status Related to High Disease Burden

Author

Pietrantonio, Filippo, primary, Loupakis, Fotios, additional, Randon, Giovanni, additional, Raimondi, Alessandra, additional, Salati, Massimiliano, additional, Trapani, Dario, additional, Pagani, Filippo, additional, Depetris, Ilaria, additional, Maddalena, Giulia, additional, Morano, Federica, additional, Corallo, Salvatore, additional, Prisciandaro, Michele, additional, Corti, Francesca, additional, Guarini, Vincenzo, additional, Bocconi, Alessandro, additional, Marra, Antonio, additional, Belli, Carmen, additional, Spallanzani, Andrea, additional, Fassan, Matteo, additional, Lonardi, Sara, additional, Curigliano, Giuseppe, additional, Fucà, Giovanni, additional, Di Bartolomeo, Maria, additional, and de Braud, Filippo, additional

Published
2020
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11. Predictive Role Of Body Composition Parameters In Operable Breast Cancer Patients Treated With Neoadjuvant Chemotherapy

Author

Omarini,Claudia, Palumbo,Patrizia, Pecchi,Annarita, Draisci,Stefano, Balduzzi,Sara, Nasso,Cecilia, Barbolini,Monica, Isca,Chrystel, Bocconi,Alessandro, Moscetti,Luca, Galetti,Silvia, Tazzioli,Giovanni, Torricelli,Pietro, Cascinu,Stefano, Piacentini,Federico, Omarini, C., Palumbo, P., Pecchi, A., Draisci, S., Balduzzi, S., Nasso, C., Barbolini, M., Isca, C., Bocconi, A., Moscetti, L., Galetti, S., Tazzioli, G., Torricelli, P., Cascinu, S., and Piacentini, F.

Subjects
Sarcopenia, Pathological complete response, Fat tissue, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, sarcopenia, BMI, breast cancer, Breast cancer, Cancer Management and Research, pathological complete response, fat tissue, BMI, fat tissue, sarcopenia, pathological complete response, breast cancer, Original Research
Abstract

Claudia Omarini,1 Patrizia Palumbo,2 Annarita Pecchi,3 Stefano Draisci,3 Sara Balduzzi,4 Cecilia Nasso,1 Monica Barbolini,1 Chrystel Isca,1 Alessandro Bocconi,1 Luca Moscetti,1 Silvia Galetti,5 Giovanni Tazzioli,6 Pietro Torricelli,3 Stefano Cascinu,1 Federico Piacentini1 1Division of Medical Oncology, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena, Modena, Italy; 2Division of Clinical Nutrition and Metabolism, Department of Specialist Medicines, University Hospital of Modena, Modena, Italy; 3Department of Radiology, University Hospital of Modena, Modena, Italy; 4Statistics Unit, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena, Modena, Italy; 5Division of Clinical Nutrition and Metabolism, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena, Modena, Italy; 6Department of General Surgery and Surgical Specialities, University Hospital of Modena, Modena, ItalyCorrespondence: Claudia OmariniDivision of Medical Oncology, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena, Via Del Pozzo 71, Modena 41122, ItalyTel +39 059 4222845Email claudia.omarini@gmail.comBackground: Fat tissue is strongly involved in BC tumorigenesis inducing insulin resistance, chronic inflammation and hormonal changes. Computed tomography (CT) imaging instead of body mass index (BMI) gives a reliable measure of skeletal muscle mass and body fat distribution. The impact of body composition parameters (BCPs) on chemosensitivity is still debated. We examined the associations between BCPs and tumor response to neoadjuvant chemotherapy (NC) in patients treated for operable breast cancer (BC).Methods: A retrospective review of BC patients treated with NC in Modena Cancer Center between 2005 and 2017 was performed. BCPs, such as subcutaneous fat area (SFA), visceral fat area (VFA), lumbar skeletal muscle index (LSMI) and liver-to-spleen (L/S) ratio were calculated by Advance workstation (General Electric), software ADW server 3.2 or 4.7. BMI and BCPs were correlated with pathological complete response (pCR) and survival outcomes.Results: 407 patients were included in the study: 55% with BMI < 25 and 45% with BMI ≥ 25. 137 of them had pre-treatment CT scan imagines. Overweight was significantly associated with postmenopausal status and older age. Hormonal receptor positive BC was more frequent in overweight patients (p

Published
2019

14. Predictive Role Of Body Composition Parameters In Operable Breast Cancer Patients Treated With Neoadjuvant Chemotherapy

Author

Omarini, Claudia, primary, Palumbo, Patrizia, additional, Pecchi, Annarita, additional, Draisci, Stefano, additional, Balduzzi, Sara, additional, Nasso, Cecilia, additional, Barbolini, Monica, additional, Isca, Chrystel, additional, Bocconi, Alessandro, additional, Moscetti, Luca, additional, Galetti, Silvia, additional, Tazzioli, Giovanni, additional, Torricelli, Pietro, additional, Cascinu, Stefano, additional, and Piacentini, Federico, additional

Published
2019
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15. Determination of Plane Convex Sets through X-rays

Author

Bocconi, Alessandro

Abstract

We prove that, for a fixed positive number $\delta$ and two directions in the plane, it is possible to choose a third direction so that if the Alane convex sets H and K have the same X-rays along there directions, the measure of their symmetric difference is less than $\delta$.

Published
1997

16. CtDNA-guided rechallenge with anti-EGFR therapy in RASwt metastatic colorectal cancer: Evidence from clinical practice.

Author

D'Onofrio R, Caputo F, Prampolini F, Spallanzani A, Gelsomino F, Bettelli S, Manfredini S, Reggiani Bonetti L, Carotenuto P, Bocconi A, Dominici M, Luppi G, and Salati M

Subjects
Humans, Progression-Free Survival, Mutation, Colorectal Neoplasms drug therapy, Colorectal Neoplasms genetics, Colorectal Neoplasms pathology, Colonic Neoplasms, Rectal Neoplasms
Abstract

Aim: To apply extended ctDNA-based RAS genotyping to clinical criteria for improving the selection of patients eligible for anti-EGFR-based rechallenge in a real-world setting., Methods: ctDNA testing was prospectively applied to RASwt mCRC progressed after a first-line anti-EGFR-containing regimen and at least one other line. The primary endpoint was the objective response rate., Results: Among ten enrolled patients, the anti-EGFR rechallenge resulted in an objective response rate and disease control rate of 70% and 90%. The median progression-free survival was 11.3 months and overall survival was not reached. Compared with a historical cohort retreated with anti-EGFR agents based on clinical criteria, the ctDNA-driven approach resulted in a higher chance of achieving an objective response and longer survival., Conclusions: Blood-based RASwt status may enrich metastatic colorectal cancer more likely to benefit from anti-EGFR-based rechallenge. RAS genotyping in ctDNA represents a feasible, fast, and cost-effective tool to be implemented in the clinic for advancing precision medicine.

Published
2023
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