196 results on '"Bockting, C. L. H."'
Search Results
2. Antidepressiva: al decennia voorgeschreven én toch nog steeds bekritiseerd; een perspectief op oorzaken en oplossingen
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Ormel, J, Ruhé, H G, Bockting, C L H, Nolen, W, Schene, A H, Spijker, J, Ten Doesschate, M, Cramer, A O J, Verhaak, P, Spinhoven, P, Adult Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, APH - Personalized Medicine, APH - Digital Health, Experimental Psychotherapy & Psychopathology, Interdisciplinair Centrum voor Psychopathologie en Emotieregulatie, and Clinical Cognitive Neuropsychiatry Research Program (CCNP)
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Antidepressant medication ,Effectiveness ,Long-term outcome - Abstract
BACKGROUND: From around 1980, antidepressants (ad) have increasingly been prescribed, for longer periods of time, especially selective serotonin reuptake inhibitors (ssris). Paradoxically, their effectiveness is still doubted, especially outside the psychiatric profession. AIM: To explain increase and offer a perspective on causes and solutions, and to indicate how to reach consensus. METHOD: Position paper with critical analysis and synthesis of relevant literature. RESULTS: The rise in AD prescriptions results from: 1. increased safety and ease of prescribing, 2. increased presentation and recognition of depression in primary care, 3. extension of indication criteria, 4. effective marketing strategies, and 5. effectiveness in acute phase (aad) and of relapse/recurrence prevention in continuation/maintenance phases (coad).Critics point to: 1. low added value of aad relative to placebo, 2. many drop-outs and non-responders, 3. relapse/recurrence prevention with coad works only for responders to aad, 4. relapse/recurrence after AD discontinuation often involves withdrawal symptoms, and 5. publication bias, selective reporting, selective patient selection, and suboptimal blinding, resulting in overestimated effectiveness and underestimated disadvantages.Factors that keep fueling the controversy are: 1. critics stress the net effectiveness of AD whereas proponents point at gross effectiveness which includes spontaneous recovery and placebo effect; 2. persistence of distrust in industry-funded rcts; 3. ideological positions, reinforced by conflicts of interest and selective citations; 4. lack of rcts with relevant long-term outcome measurements. CONCLUSION: Although consensus is difficult to achieve given the ideological component, there are options. Three factors are critically important: confer to establish which data convince the opposition, response prediction (what works for whom), and rcts with long-term functional outcomes.
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- 2020
3. Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts
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Thesing, C. S., primary, Lok, A., additional, Milaneschi, Y., additional, Assies, J., additional, Bockting, C. L. H., additional, Figueroa, C. A., additional, Giltay, E. J., additional, Penninx, B. W. J. H., additional, Ruhé, H. G., additional, Schene, A. H., additional, Bot, M., additional, and Mocking, R. J. T., additional
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- 2019
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4. The decision tool unipolar depression (DTUD): a new measure to facilitate the early identification of patients with major depressive disorder in need of highly specialized care
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van Krugten, Frédérique C. W., Goorden, Maartje, van Balkom, Anton J. L. M., van Oppen, Patricia, Ruhé, Henricus G., van Schaik, Digna J. F., Brouwer, Werner B. F., Hakkaart-van Roijen, Leona, van Balkom, A. J. L. M., Bockting, C. L. H., van den Boogaard, T. M., van Schaik, D. J. F., van Oppen, P., Ruhé, H. G., Peeters, F. P. M. L., Spijker, J., Huijs, P. A. J. M., Loo, M. A. J. M., van, H. L., Broekema, W. J., van't Thijs-van't Hoog, A. E., Health Technology Assessment (HTA), Applied Economics, APH - Mental Health, Psychiatry, Adult Psychiatry, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Personalized Medicine, and APH - Digital Health
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Adult ,Male ,Adolescent ,Psychometrics ,lcsh:RC435-571 ,Clinical Decision-Making ,Youden's J statistic ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,Major depressive disorder ,Treatment stratification ,Early intervention ,Experimental Psychopathology and Treatment ,Young Adult ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,0302 clinical medicine ,lcsh:Psychiatry ,Validation ,Tertiary healthcare ,Criterion validity ,Humans ,Medicine ,030212 general & internal medicine ,Reliability (statistics) ,Depression (differential diagnoses) ,Aged ,Netherlands ,Psychiatric Status Rating Scales ,Depressive Disorder ,Depressive Disorder, Major ,Measurement ,Receiver operating characteristic ,Depression ,business.industry ,Reproducibility of Results ,Middle Aged ,medicine.disease ,3. Good health ,030227 psychiatry ,Psychiatry and Mental health ,Cross-Sectional Studies ,Treatment Outcome ,Convergent validity ,Female ,business ,Research Article ,Clinical psychology - Abstract
Background Selection of the optimal initial treatment in patients with major depressive disorder (MDD) in need of highly specialized care has the potential to benefit treatment outcomes and cost-effectiveness of treatment strategies. However, to date, there is a paucity of measures that could guide the selection of the initial treatment, in particular to indicate which patients with MDD are in need of highly specialized care. Recognizing this gap, this paper reports on the development and psychometric evaluation of the Decision Tool Unipolar Depression (DTUD), aimed to facilitate the early identification of patients with MDD in need of highly specialized care. Methods The DTUD was developed using a mixed-methods approach, consisting of a systematic review and a concept mapping study. To evaluate the psychometric features of the DTUD, a cross-sectional multicenter study was conducted. A total of 243 patients with MDD were evaluated with the DTUD. Feasibility was operationalized as the time required to complete the DTUD and the content clarity of the DTUD. Inter-rater reliability was evaluated using Krippendorf’s alpha. The Maudsley Staging Method (MSM) and the Dutch Measure for quantification of Treatment Resistance in Depression (DM-TRD) were administered to assess the convergent validity. A receiver operator characteristic curve was generated to evaluate the criterion validity and establish the optimal cut-off value. Results The mean administration time was 4.49 min (SD = 2.71), and the content of the total DTUD was judged as clear in 94.7% of the evaluations. Inter-rater reliability values ranged from 0.69 to 0.91. Higher scores on the DTUD were associated with higher scores on the MSM (rs = 0.47) and DM-TRD (rs = 0.53). Based on the maximum Youden index (0.494), maximum discrimination was reached at a cut-off score of ≥5 (sensitivity 67%, specificity 83%). Conclusion The DTUD demonstrated to be a tool with solid psychometric properties and, therefore, is a promising measure for the early identification of patients with MDD in need of highly specialized care. Use of the DTUD has the potential to facilitate the selection and initiation of the optimal initial treatment in patients with MDD, which in turn may improve the clinical effectiveness and cost-effectiveness of treatment strategies. Electronic supplementary material The online version of this article (10.1186/s12888-019-2165-9) contains supplementary material, which is available to authorized users.
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- 2019
5. Emotion regulation mediates the effect of childhood trauma on depression
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Hopfinger, Lisa, Bockting, C. L. H., Berking, Matthias, Ebert, David D., Leerstoel Bockting, Trauma and Grief, Leerstoel Bockting, Trauma and Grief, Adult Psychiatry, APH - Mental Health, and Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep
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Child abuse ,Adult ,Male ,medicine.medical_specialty ,Mediation (statistics) ,Adolescent ,Cross-sectional study ,Emotions ,Mediator ,Dysfunctional family ,Childhood trauma ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Surveys and Questionnaires ,medicine ,Psychology ,Humans ,Child Abuse ,Depression lifetime persistency ,Child Abuse/psychology ,Young adult ,Psychiatry ,Child ,Depression (differential diagnoses) ,Aged ,Depressive Disorder ,Emotion regulation ,Hamilton Rating Scale for Depression ,Depression severity ,Middle Aged ,medicine.disease ,Regression ,030227 psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Major depressive disorder ,Female ,Depressive Disorder/psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Background Childhood trauma increases the risks of both depression and dysfunctional emotion regulation, which is a factor that has been strongly linked to depression. Because of these demonstrated relationships, it can be hypothesized that dysfunctional emotion regulation is a mediator of the association between childhood trauma and depression. Methods To test this hypothesis, we assessed the indirect effect of emotion regulation (Emotion Regulation Skills Questionnaire) on the relationship between childhood trauma (Childhood Trauma Questionnaire) and depression severity (24-item Hamilton Rating Scale for Depression) as well as depression lifetime persistency (i.e., lifetime percentage spent in major depressive episodes; assessed via SCID and Life Chart Interviews) in 269 patients with major depressive disorder (MDD). Results Bootstrapping-enhanced mediation analyses indicated that deficits in general emotion regulation mediated the association of childhood trauma to both depression severity and depression lifetime persistency. Further exploratory analyses indicated that specific emotion regulation skills (such as the ability to mindfully observe, accept, and tolerate undesired emotions or the willingness to voluntarily confront situations that prompt negative emotions in order to attain personally relevant goals) significantly mediated the association between childhood trauma and depression severity. Willingness to confront was a mediator for both depression outcomes (depression severity and lifetime persistency). Limitations The employed mediation analyses are cross-sectional in nature, which limits any firm conclusions regarding causality. Conclusions The findings support the assumption that a sophisticated emotion regulation may help prevent the onset or unfavorable course of depression in individuals who have experienced childhood trauma.
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- 2016
6. Network destabilization and transition in depression
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Hayes, A. M., Yasinski, C., Ben Barnes, J., Bockting, C. L. H., Trauma and Grief, Leerstoel Bockting, Universiteit Utrecht, and Clinical Psychology and Experimental Psychopathology
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DISORDER ,Psychotherapist ,System change ,Psychotherapeutic Processes ,medicine.medical_treatment ,Social Sciences ,Treatment research ,CRITICAL SLOWING-DOWN ,Emotional processing ,Models, Psychological ,Article ,Dynamic systems theory ,CLINICAL DEPRESSION ,Depression (economics) ,Models ,medicine ,Humans ,RECURRENT DEPRESSION ,skin and connective tissue diseases ,NEURAL MECHANISMS ,Cognitive change in depression ,SYMPTOM CHANGE ,Depressive Disorder, Major ,Depressive Disorder ,Management science ,Depression ,Transition (fiction) ,COGNITIVE THERAPY ,Cognition ,SELF-SCHEMA ,Psychiatry and Mental health ,Clinical Psychology ,Dynamics (music) ,EMOTION-REGULATION ,Cognitive therapy ,Psychological ,sense organs ,Psychology ,Major/psychology ,Psychological Theory ,Chronic depression ,FUTURE-DIRECTIONS - Abstract
The science of dynamic systems is the study of pattern formation and system change. Dynamic systems theory can provide a useful framework for understanding the chronicity of depression and its treatment. We propose a working model of therapeutic change with potential to organize findings from psychopathology and treatment research, suggest new ways to study change, facilitate comparisons across studies, and stimulate treatment innovation. We describe a treatment for depression that we developed to apply principles from dynamic systems theory and then present a program of research to examine the utility of this application. Recent methodological and technological developments are also discussed to further advance the search for mechanisms of therapeutic change.
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- 2015
7. Therapygenetics: the 5HTTLPR as a biomarker for response to psychological therapy?
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Bockting, C L H, Mocking, R J, Lok, A, Koeter, M W J, and Schene, A H
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- 2013
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8. From loss to loneliness: The relationship between bereavement and depressive symptoms
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Fried, E. I., Bockting, C. L. H., Arjadi, R., Borsboom, D., Amshoff, M., Cramer, A. O. J., Epskamp, S., Tuerlinckx, F., Carr, D., Stroebe, M., Trauma and Grief, Leerstoel Bockting, Clinical Psychology and Experimental Psychopathology, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Psychologische Methodenleer (Psychologie, FMG), Trauma and Grief, and Leerstoel Bockting
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Male ,medicine.medical_specialty ,media_common.quotation_subject ,Poison control ,Affect (psychology) ,Suicide prevention ,Social network analyses ,Injury prevention ,80 and over ,loneliness ,medicine ,Humans ,Psychiatry ,Biological Psychiatry ,Aged ,media_common ,Aged, 80 and over ,bereavement ,Loneliness/psychology ,Loneliness ,Center for Epidemiologic Studies Depression Scale ,Sadness ,Clinical Psychology ,Psychiatry and Mental health ,depression ,Female ,Grief ,medicine.symptom ,Psychology ,Depression/psychology ,Follow-Up Studies ,Clinical psychology - Abstract
Spousal bereavement can cause a rise in depressive symptoms. This study empirically evaluates 2 competing explanations concerning how this causal effect is brought about: (a) a traditional latent variable explanation, in which loss triggers depression which then leads to symptoms; and (b) a novel network explanation, in which bereavement directly affects particular depression symptoms which then activate other symptoms. We used data from the Changing Lives of Older Couples (CLOC) study and compared depressive symptomatology, assessed via the 11-item Center for Epidemiologic Studies Depression Scale (CES-D), among those who lost their partner (N = 241) with a still-married control group (N = 274). We modeled the effect of partner loss on depressive symptoms either as an indirect effect through a latent variable, or as a direct effect in a network constructed through a causal search algorithm. Compared to the control group, widow(er)s' scores were significantly higher for symptoms of loneliness, sadness, depressed mood, and appetite loss, and significantly lower for happiness and enjoyed life. The effect of partner loss on these symptoms was not mediated by a latent variable. The network model indicated that bereavement mainly affected loneliness, which in turn activated other depressive symptoms. The direct effects of spousal loss on particular symptoms are inconsistent with the predictions of latent variable models, but can be explained from a network perspective. The findings support a growing body of literature showing that specific adverse life events differentially affect depressive symptomatology, and suggest that future studies should examine interventions that directly target such symptoms. (PsycINFO Database Record (c) 2015 APA, all rights reserved).
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- 2015
9. Personality and cognitive vulnerability in remitted recurrently depressed patients
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van Rijsbergen, G. D., Kok, G. D., Elgersma, H. J., Hollon, S. D., Bockting, C. L. H., Trauma and Grief, Leerstoel Bockting, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Clinical Psychology and Experimental Psychopathology
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Male ,medicine.medical_specialty ,recurrence ,Personality Inventory ,media_common.quotation_subject ,Culture ,Dysfunctional family ,Netherlands/epidemiology ,Depressive Disorder, Major/epidemiology ,Comorbidity ,Treatment response ,Personality Disorders ,Personality Disorders/epidemiology ,COGNITIVE REACTIVITY ,Cognition ,medicine ,Prevalence ,Personality ,Humans ,RECURRENT DEPRESSION ,Psychiatry ,COMORBID DEPRESSION ,RUMINATION ,media_common ,Netherlands ,Cognitive vulnerability ,Depressive Disorder, Major ,Personality disorder ,Major/epidemiology ,Personality pathology ,COMORBID CONDITIONS ,Middle Aged ,medicine.disease ,cognitive model ,Personality disorders ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Attitude ,Rumination ,DEPRESSIVE DISORDER ,Major depressive disorder ,Dysfunctional Beliefs ,Female ,medicine.symptom ,PERSONALITY DIMENSIONS ,Psychology ,Clinical psychology - Abstract
INTRODUCTION: Personality disorders (PDs) have been associated with a poor prognosis of Major Depressive Disorder (MDD). The aim of the current study was to examine cognitive vulnerability (i.e., dysfunctional beliefs, extremity of beliefs, cognitive reactivity, and rumination) that might contribute to this poor prognosis of patients with PD comorbidity.METHODS: 309 outpatients with remitted recurrent MDD (SCID-I; HAM-D17≤10) were included within two comparable RCTs and were assessed at baseline with the Personality Diagnostic Questionnaire-4(+) (PDQ-4(+)), the Dysfunctional Attitude Scale Version-A (DAS-A), the Leiden Index of Depression Sensitivity (LEIDS), the Ruminative Response Scale (RRS), and the Inventory of Depressive Symptomatology-Self Report (IDS-SR).RESULTS: We found an indication that the PD prevalence was 49.5% in this remitted recurrently depressed sample. Having a PD (and higher levels of personality pathology) was associated with dysfunctional beliefs, cognitive reactivity, and rumination. Extreme 'black and white thinking' on the DAS was not associated with personality pathology. Brooding was only associated with a Cluster C classification (t(308)=4.03, pLIMITATIONS: PDs were assessed by questionnaire and the analyses were cross-sectional in nature.CONCLUSION: Being the first study to examine cognitive reactivity and rumination in patients with PD and remitted MDD, we demonstrated that even after controlling for depressive symptomatology, dysfunctional beliefs, cognitive reactivity, and rumination were associated with personality pathology. Rumination might be a pathway to relapse for patients with avoidant PD. Replication of our findings concerning cognitive vulnerability and specific PDs is necessary.
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- 2015
10. Effectiveness of psychological interventions in preventing recurrence of depressive disorder: Meta-analysis and meta-regression
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Biesheuvel-Leliefeld, K. E. M., Kok, G. D., Bockting, C. L. H., Cuijpers, P., Hollon, S. D., van Marwijk, H. W. J., Smit, F., Trauma and Grief, Leerstoel Bockting, Clinical Psychology and Experimental Psychopathology, General practice, Epidemiology and Data Science, EMGO - Mental health, Trauma and Grief, Leerstoel Bockting, Clinical Psychology, and EMGO+ - Mental Health
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medicine.medical_specialty ,Population ,Psychological intervention ,Major depressive disorder ,Antidepressive Agents/therapeutic use ,SDG 3 - Good Health and Well-being ,Recurrence ,Internal medicine ,medicine ,Humans ,Combined Modality Therapy ,Meta-regression ,Relapse ,Relapse risk ,Psychiatry ,education ,Depressive Disorder ,Depressive Disorder, Major ,education.field_of_study ,Prevention ,Health sciences ,medicine.disease ,Antidepressive Agents ,Psychotherapy ,Meta-analysis ,Psychiatry and Mental health ,Clinical Psychology ,Relative risk ,Major/drug therapy ,Regression Analysis ,Psychology - Abstract
BACKGROUND: Major depression is probably best seen as a chronically recurrent disorder, with patients experiencing another depressive episode after remission. Therefore, attention to reduce the risk of relapse or recurrence after remission is warranted. The aim of this review is to meta-analytically examine the effectiveness of psychological interventions to reduce relapse or recurrence rates of depressive disorder.METHODS: We systematically reviewed the pertinent trial literature until May 2014. The random-effects model was used to compute the pooled relative risk of relapse or recurrence (RR). A distinction was made between two comparator conditions: (1) treatment-as-usual and (2) the use of antidepressants. Other sources of heterogeneity in the data were explored using meta-regression.RESULTS: Twenty-five randomised trials met inclusion criteria. Preventive psychological interventions were significantly better than treatment-as-usual in reducing the risk of relapse or recurrence (RR=0.64, 95% CI=0.53-0.76, z=4.89, pLIMITATIONS: Differences between the primary studies in methodological design, composition of the patient groups and type of intervention may have caused heterogeneity in the data, but could not be evaluated in a meta-regression owing to poor reporting.CONCLUSIONS: We conclude that there is supporting evidence that preventive psychological interventions reduce the risk of relapse or recurrence in major depression.
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- 2015
11. The Three-Month Effect of Mobile Internet-Based Cognitive Therapy on the Course of Depressive Symptoms in Remitted Recurrently Depressed Patients: Results of a Randomized Controlled Trial
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Kok, G. D., Burger, H., Riper, H., Cuijpers, P., Dekker, J., van Marwijk, H., Smit, F., Beck, A., Bockting, C. L. H., Trauma and Grief, Leerstoel Bockting, Clinical Psychology, EMGO+ - Mental Health, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Psychiatry, General practice, Epidemiology and Data Science, EMGO - Mental health, Trauma and Grief, Leerstoel Bockting, Clinical Psychology and Experimental Psychopathology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Reproductive Origins of Adult Health and Disease (ROAHD), and Life Course Epidemiology (LCE)
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TELEPHONE ,medicine.medical_specialty ,Randomization ,Monitoring ,medicine.medical_treatment ,mobile intervention ,Cognitive therapy ,MAINTENANCE TREATMENT ,Relapse prevention ,Affect (psychology) ,law.invention ,Text mining ,SDG 3 - Good Health and Well-being ,Randomized controlled trial ,law ,Internal medicine ,PSYCHOTHERAPY ,medicine ,BEHAVIORAL TREATMENT ,blended care ,Psychiatry ,relapse prevention ,METAANALYSIS ,Applied Psychology ,Depression (differential diagnoses) ,Internet-based therapy ,business.industry ,Panic disorder ,Health sciences ,MAJOR DEPRESSION ,General Medicine ,Recurrent depression ,medicine.disease ,PANIC DISORDER ,AFFECTIVE-DISORDERS ,Treatment ,Psychiatry and Mental health ,Clinical Psychology ,depression ,business ,Psychology ,RESIDUAL SYMPTOMS - Abstract
Background: Internet-based cognitive therapy with monitoring via text messages (mobile CT), in addition to treatment as usual (TAU), might offer a cost-effective way to treat recurrent depression. Method: Remitted patients with at least 2 previous episodes of depression were randomized to mobile CT in addition to TAU (n = 126) or TAU only (n = 113). A linear mixed model was used to examine the effect of the treatment condition on a 3-month course of depressive symptoms after remission. Both an intention-to-treat analysis (n = 239) and a completer analysis (n = 193) were used. Depressive symptoms were assessed using the Inventory of Depressive Symptomatology (IDS-SR30) at baseline and 1.5 and 3 months after randomization. Results: Residual depressive symptoms showed a small but statistically significant decrease in the intention-to-treat group over 3 months in the mobile CT group relative to the TAU group (difference: -1.60 points on the IDS-SR30 per month, 95% CI = -2.64 to -0.56, p = 0.003). The effect of the treatment condition on the depressive symptomatology at the 3-month follow-up was small to moderate (Cohen's d = 0.44). All analyses among completers (≥5 modules) showed more pronounced treatment effects. Adjustment for unequally distributed variables did not markedly affect the results. Conclusions: Residual depressive symptoms after remission showed a more favorable course over 3 months in the mobile CT group compared to the TAU group. These results are a first indication that mobile CT in addition to TAU is effective in treating recurrently depressed patients in remission. However, demonstration of its long-term effectiveness and replication remains necessary.
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- 2015
12. Predictive accuracy of Edinburgh Postnatal Depression Scale assessment during pregnancy for the risk of developing postpartum depressive symptoms
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Meijer, J. L., Beijers, C., van Pampus, M. G., Verbeek, T., Milgrom, J., Bockting, C. L. H., Burger, H., Stolk, R.P., Trauma and Grief, Social Urban Transitions, SGPL Economische Geografie, Leerstoel Bockting, LS IRAS EEPI GRA (Gezh.risico-analyse), Trauma and Grief, Social Urban Transitions, SGPL Economische Geografie, Leerstoel Bockting, LS IRAS EEPI GRA (Gezh.risico-analyse), Clinical Psychology and Experimental Psychopathology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Reproductive Origins of Adult Health and Disease (ROAHD), and Lifestyle Medicine (LM)
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Postpartum depression ,Adult ,medicine.medical_specialty ,STRESS ,Adolescent ,Population ,Risk Assessment ,Sensitivity and Specificity ,Depression, Postpartum ,Young Adult ,CHILD ,Pregnancy ,QUESTIONS ,Prenatal Diagnosis ,Surveys and Questionnaires ,medicine ,Humans ,ANXIETY ,Prospective Studies ,Prospective cohort study ,Psychiatry ,education ,Netherlands ,education.field_of_study ,Antenatal depression ,Obstetrics ,business.industry ,Depression ,Obstetrics and Gynecology ,WOMEN ,Middle Aged ,medicine.disease ,PREVALENCE ,Pregnancy Complications ,Mood ,predictive accuracy ,postpartum depression ,Edinburgh Postnatal Depression Scale ,Anxiety ,Female ,SCREEN ,medicine.symptom ,business ,Cohort study - Abstract
To investigate whether the 10-item Edinburgh Postnatal Depression Scale (EPDS) administered antenatally is accurate in predicting postpartum depressive symptoms, and whether a two-item EPDS has similar predictive accuracy.Prospective cohort study.Obstetric care in the Netherlands.One thousand six hundred and twenty women from the general population.Mean values, area under the receiver operating characteristics curve (AUC), sensitivity, specificity and predictive values of antenatal EPDS for the likelihood of developing postpartum depressive symptoms were calculated. Analyses were repeated for each trimester, several cut-off values and a two-item EPDS (low mood and anhedonia).Postpartum depressive symptoms, defined as EPDS score≥10.Mean EPDS scores were significantly higher during each trimester in women with postpartum depressive symptoms than in those without the symptoms (P0.001). Using the prevailing cut-off (≥13), the AUC was reasonable (0.74), sensitivity was 16.8% (95% CI 11.0-24.1), positive predictive value was 41.8% (95% CI 28.7-55.9), specificity was 97.8% (95% CI 97.0-98.5) and negative predictive value was 92.7% (95% CI 91.3-94.0). Using a lower cut-off value (≥5), sensitivity was 70.8% (95% CI 62.4-78.3) and specificity was 65.4% 4 (95% CI 62.9-67.8), but positive predictive value was low (15.9%, 95% CI 13.1-19.0). Negative predictive value was exceedingly high at 96.0% (95% CI 94.6-97.2). Results were similar during the second and third trimester. The predictive accuracy of the two-item EPDS appeared inferior.The EPDS was not sufficiently accurate in predicting risk of postpartum depressive symptoms. Nevertheless, when using the ≥5 cut-off value, it may be adequate for initial screening, followed by further assessments and possibly antenatal intervention when positive. Furthermore, when negative, women may be reassured that postpartum depressive symptoms are unlikely. A two-item version showed poor predictive accuracy.
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- 2014
13. The role of affect in predicting depressive symptomatology in remitted recurrently depressed patients
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de Jonge, Margo, Dekker, J. J M, Kikkert, M. J., Peen, J., van Rijsbergen, G. D., Bockting, C. L H, Sub OGC Onderzoekers, Leerstoel Bockting, Clinical Psychology (onderzoeksprogramma), Radiology and Nuclear Medicine, Graduate School, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Sub OGC Onderzoekers, Leerstoel Bockting, Clinical Psychology (onderzoeksprogramma), Clinical Psychology, and Clinical Psychology and Experimental Psychopathology
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Adult ,Male ,medicine.medical_specialty ,Relapse prevention ,Affect (psychology) ,Depressive symptomatology ,Mood scale ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Predictive Value of Tests ,Recurrence ,Mood ,medicine ,Humans ,Relapse ,Psychiatry ,Self report ,Depression (differential diagnoses) ,Psychiatric Status Rating Scales ,Depressive Disorder, Major ,Depressive Disorder ,Depression ,Middle Aged ,medicine.disease ,030227 psychiatry ,Depressive Disorder, Major/psychology ,Psychiatry and Mental health ,Clinical Psychology ,Affect ,Remitted ,Major depressive disorder ,Female ,Self Report ,Psychology ,Major/psychology ,Depression/psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
BACKGROUND: Major depressive disorder is an emotional disorder. It is important to improve our understanding of the role of affect in relapse/recurrence of depression. Therefore, this study examines whether affect plays a role in prospectively predicting depressive symptomatology and if there are indications for emotional scarring as a consequence of undergoing depressive episodes.METHODS: In 107 patients remitted from recurrent depression affect was examined in predicting depressive symptomatology as measured with the Inventory of Depressive Symptomatology - Self Report. Affect was measured with the Positive and Negative Affect Schedule and with a one item Visual Analogue Mood Scale. Indication of emotional scarring was examined by comparing number of previous depressive episodes to levels of affect.RESULTS: Less positive affect as assessed after remission predicted increased depressive symptomatology six months later, even after we controlled for baseline symptomatology. Negative affect also predicted depressive symptomatology six months later, but not after controlling for baseline depressive symptomatology. No relationship was found between affect and number of previous episodes.LIMITATIONS: All participants in this study had two or more previous depressive episodes and received CBT during the acute phase of their depression. The instruments that measured mood and affect were administered within 4 weeks of each other.CONCLUSIONS: Positive affect and negative affect as assessed after remission in recurrent depression can predict depressive symptomatology. Especially positive affect seems to play an independent role in predicting depressive symptomatology. Directly targeting positive affect in relapse prevention during remission might be a way to enhance treatment effects.
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- 2017
14. Red ROM als kwaliteitsinstrument
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de Jong, Kim, Tiemens, Bea, Verbraak, Marc, Beekman, A. F. T., Bockting, C. L. H., Bouman, T. K., Castelein, S., van Dyck, R., Emmelkamp, P. M. G., van der Feltz-Cornelis, C. M., van der Gaag, M., Huibers, M. J. H., Hutschemaekers, G. J. M., de Keijser, A., Keijsers, G. P. J., Koekkoek, B., Korrelboom, K., van Minnen, A., van Oppen, P. C., Oudejans, S. C. C., Oude Voshaar, R. C., Schippers, G. M., Scholing, A., Spijker, J., Spinhoven, Ph., van Straten, A., Vermeiren, R. R. J. M., Zitman, F. G., Experimental Psychotherapy & Psychopathology, Clinical Cognitive Neuropsychiatry Research Program (CCNP), and Interdisciplinair Centrum voor Psychopathologie en Emotieregulatie
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- 2017
15. The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder; influence of antidepressant use and depressive state?
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Lok, A., Mocking, R. J. T., Assies, W. J., Koeter, M. W. J., Bockting, C. L. H., De Vries, G. J., Visser, I., Derks, E. M., Kayser, M., Schene, A. H., Trauma and Grief, Leerstoel Bockting, Trauma and Grief, Leerstoel Bockting, Adult Psychiatry, Other departments, Clinical Psychology and Experimental Psychopathology, and Genetic Identification
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Male ,Oncology ,Folate ,SYMPTOMS ,Homocysteine ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,chemistry.chemical_compound ,PLASMA HOMOCYSTEINE LEVELS ,Methylenetetrahydrofolate Reductase ,Recurrence ,Mthfr c677t ,education.field_of_study ,biology ,THERMOLABILE VARIANT ,FOLATE STATUS ,U.S. ADULTS ,ASSOCIATION ,Middle Aged ,Antidepressive Agents ,Pathophysiology ,Vitamin B 12 ,Psychiatry and Mental health ,Clinical Psychology ,Major depressive disorder ,Antidepressant ,Female ,HEALTH ,Adult ,medicine.medical_specialty ,Population ,METABOLISM ,Folic Acid ,(NADPH2)/genetics ,Internal medicine ,medicine ,Humans ,education ,Methylenetetrahydrofolate Reductase (NADPH2) ,Depressive Disorder, Major ,Polymorphism, Genetic ,Depressive disorder ,business.industry ,medicine.disease ,Carbon ,Vitamin B 6 ,Endocrinology ,Vitamin B6 ,chemistry ,VITAMIN-B-12 ,Case-Control Studies ,Methylenetetrahydrofolate reductase ,OLDER WOMEN ,biology.protein ,Vitamin b6 ,business - Abstract
Item does not contain fulltext BACKGROUND: An important biological factor suggested in the pathophysiology of (recurrent) Major Depressive Disorder (MDD) concerns a polymorphism in a gene encoding for the MTHFR-enzyme of the one-carbon (1-C)-metabolism. Integratively investigating key 1-C-components (folate, homocysteine, vitamin B6 and B12), including the possible effects of antidepressant medication and depressive state, could provide more insight in the possible association between the MTHFR-polymorphism and recurrent MDD. METHODS: We compared the MTHFR C677T-polymorphism together with the key 1-C-components in clinically ascertained patients with recurrent MDD (n=137) to age- and gender-matched healthy controls (n=73). RESULTS: First, patients had lower folate (t=2.25; p=.025) as compared to controls; a difference that resolved after correction for demographics (t=1.22; p=.223). Second, patients that were depressed during sampling had lower vitamin B6 (t=-2.070; p=.038) and higher homocysteine (t=2.404; p=.016) compared to those in remission. Finally, current use of antidepressants had no influence on the 1-C-components. CONCLUSIONS: Despite investigation of a specific recurrently depressed patient population, we found no clear associations with the 1-C-cycle, except for higher homocysteine and lower vitamin B6 during the depressed state. This suggests that 1-C-cycle alterations in MDD are state-associated, possibly resulting from high levels of acute (psychological) stress, and may provide a treatment target to reduce cardiovascular risk in this population. 9 p.
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- 2014
16. Continued smoking and continued alcohol consumption during early pregnancy distinctively associated with personality
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Beijers, C., Burger, H., Verbeek, T., Bockting, C. L. H., Ormel, J., Trauma and Grief, Clinical Psychology and Experimental Psychopathology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Reproductive Origins of Adult Health and Disease (ROAHD), Life Course Epidemiology (LCE), Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Trauma and Grief
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medicine.medical_treatment ,Medicine (miscellaneous) ,Anxiety ,Smoking cessation ,Toxicology ,Cohort Studies ,Pregnancy ,Alcohol consumption ,Prospective Studies ,Big Five personality traits ,Personality traits ,PREDICTORS ,media_common ,RISK ,education.field_of_study ,Alcohol Abstinence ,Depression ,Smoking ,HEALTH BEHAVIORS ,WOMEN ,PREVALENCE ,Psychiatry and Mental health ,Clinical Psychology ,Smoking Cessation/psychology ,Female ,medicine.symptom ,Psychology ,TRAITS ,Clinical psychology ,Personality ,Adult ,medicine.medical_specialty ,Alcohol Drinking ,media_common.quotation_subject ,Population ,Anxiety/psychology ,PRENATAL SMOKING ,Smoking/psychology ,DRINKING ,5-FACTOR MODEL ,medicine ,Humans ,education ,Psychiatry ,Alcohol Abstinence/psychology ,Pregnancy Complications/psychology ,medicine.disease ,Pregnancy Complications ,Alcohol Drinking/psychology ,Edinburgh Postnatal Depression Scale ,Pregnant Women ,CESSATION ,Pregnant Women/psychology ,Depression/psychology ,State-Trait Anxiety Inventory - Abstract
Pregnancy is a unique period to quit smoking and alcohol consumption and although motivated, not all women succeed at this. We investigated the associations of personality with continued smoking and continued alcohol consumption during early pregnancy. In addition, we studied whether antenatal anxiety and depressive symptoms can explain these associations. Two antenatal measurements from the population-based Pregnancy Anxiety and Depression cohort study were used. Pregnant women in their first trimester were recruited via midwifery practices and hospitals. We analyzed a sample of women who continued (n=101) or quit smoking (n=254), and a sample of women who continued (n=110) or quit alcohol consumption (n=1230). Measures included questions about smoking, alcohol consumption, the NEO-Five Factor Inventory (personality), the State Trait Anxiety Inventory, and the Edinburgh Postnatal Depression Scale. We found associations between continued alcohol consumption and higher levels of openness to experience, and lower levels of conscientiousness (p
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- 2014
17. Een systematische review van de behandeling van chronische depressie
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Spijker, J., Annemieke van Straten, Bockting, C. L. H., Meeuwissen, J. A. C., Balkom, A. J. L. M., Psychiatry, EMGO - Mental health, Clinical Psychology, and EMGO+ - Mental Health
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- 2014
18. Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts.
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Thesing, C. S., Lok, A., Milaneschi, Y., Assies, J., Bockting, C. L. H., Figueroa, C. A., Giltay, E. J., Penninx, B. W. J. H., Ruhé, H. G., Schene, A. H., Bot, M., and Mocking, R. J. T.
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MENTAL depression ,FATTY acids ,UNSATURATED fatty acids - Abstract
Objective: Omega‐3 (n‐3) and omega‐6 (n‐6) polyunsaturated fatty acid (PUFA) alterations in patients with major depressive disorder (MDD) have been shown to persist after remission. Whether these alterations are risk factors for MDD recurrence remains unknown. Here, we examined whether fatty acids predict time until MDD recurrence in remitted MDD patients. Methods: Data were used from remitted MDD patients of the Netherlands Study of Depression and Anxiety (n = 356) and the Depression Evaluation Longitudinal Therapy Assessment studies (n = 118). Associations of FAs with time until MDD recurrence up to 8‐year follow‐up were analyzed using Cox regression analyses. Study‐specific estimates were pooled using mega‐ and meta‐analysis techniques. Results: 27.5% (NESDA) and 56.8% (DELTA) participants had an MDD recurrence. Pooled results showed that no FA was significantly associated with time until MDD recurrence (n‐3 PUFAs: hazard ratio (HR) = 1.17, 95% confidence interval (CI) = 0.98–1.41, P = 0.082; n‐6 PUFAs: HR = 1.08, 95% CI = 0.84–1.38, P = 0.55). Conclusion: In remitted MDD patients, circulating PUFAs were not associated with prospective risk of MDD recurrence. Consequently, circulating PUFAs are unlikely to reflect a vulnerability marker for recurrence, so correcting n‐3 PUFA 'deficits' through supplementation does not seem a promising option to prevent MDD recurrence. [ABSTRACT FROM AUTHOR]
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- 2020
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19. The role of affect in predicting depressive symptomatology in remitted recurrently depressed patients
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Sub OGC Onderzoekers, Leerstoel Bockting, Clinical Psychology (onderzoeksprogramma), de Jonge, Margo, Dekker, J. J M, Kikkert, M. J., Peen, J., van Rijsbergen, G. D., Bockting, C. L H, Sub OGC Onderzoekers, Leerstoel Bockting, Clinical Psychology (onderzoeksprogramma), de Jonge, Margo, Dekker, J. J M, Kikkert, M. J., Peen, J., van Rijsbergen, G. D., and Bockting, C. L H
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- 2017
20. Employment status, difficulties at work and quality of life in inflammatory bowel disease patients
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De Boer, A. G., Bockting, C. L. H., Bennebroek Evertsz', F., Stokkers, P. C., Sandeman, R., Hommes, D. W., Sprangers, M. A. G., Frings-Dresen, M. H. W., Leerstoel Bockting, Trauma and Grief, Clinical Psychology and Experimental Psychopathology, Health Psychology Research (HPR), Coronel Institute of Occupational Health, Medical Psychology, and Other departments
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Male ,Social Sciences ,Efficiency ,Disease ,Hospital Anxiety and Depression Scale ,Inflammatory bowel disease ,FATIGUE ,0302 clinical medicine ,Cost of Illness ,Crohn Disease ,Quality of life ,Risk Factors ,Absenteeism ,Medicine ,030212 general & internal medicine ,PREDICTORS ,Depression (differential diagnoses) ,disability pension ,Netherlands ,Gastroenterology ,Middle Aged ,anxiety ,DEPRESSION ,Sick leave ,employment ,Health Resources ,Anxiety ,Female ,030211 gastroenterology & hepatology ,TRIAL ,medicine.symptom ,Adult ,medicine.medical_specialty ,concentration ,Adolescent ,QUESTIONNAIRE ,sick leave ,VALIDATION ,Pensions ,Young Adult ,03 medical and health sciences ,work ,inflammatory bowel disease ,Humans ,Psychiatry ,Hepatology ,business.industry ,DISABILITY ,Disability pension ,medicine.disease ,digestive system diseases ,Cross-Sectional Studies ,quality of life ,RISK-FACTORS ,Colitis, Ulcerative ,Self Report ,business - Abstract
ObjectivesTo assess employment status, difficulties at work and sick leave in inflammatory bowel disease (IBD) patients and their relation with sociodemographic and clinical factors, quality of life (QoL), and anxiety and depression.Materials and methodsIBD patients attending an IBD outpatients' clinic received self-report questionnaires on employment status, IBD-related difficulties at work and sick leave (Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness), sociodemographic factors, QoL (Inflammatory Bowel Disease Questionnaire and 12-item Short-form Health Survey) and anxiety and depression (Hospital Anxiety and Depression Scale). Disease activity was assessed by their gastroenterologist. Associations between paid employment and sick leave with sociodemographic and clinical factors, QoL and anxiety and depression were assessed by regression analyses.ResultsIn total, 202 IBD patients of working age, with a mean age of 41 years, participated; 63% had Crohn's disease and 37% had ulcerative colitis, and 57% were women and 19% had active disease. In all, 123 (61%) patients were in paid employment, of whom 31 (25%) were on sick leave, whereas 46 (23%) received a disability pension. Concentration problems (72%), low working pace (78%) and delayed work production (50%) were the most prevalent IBD-related work difficulties. IBD patients without paid employment were older and more often women, with active disease, lower QoL and higher anxiety and depression rates. Sick leave was associated with lower QoL and higher anxiety and depression rates.ConclusionMore than half of IBD patients were in paid employment, whereas almost a quarter was receiving a disability pension. A large majority experienced work difficulties. Having no paid employment was associated with poorer QoL and more anxiety and depression symptomatology.
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- 2016
21. Guided Act and Feel Indonesia (GAF-ID) - Internet-based behavioral activation intervention for depression in Indonesia: Study protocol for a randomized controlled trial
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Arjadi, R., Nauta, M. H., Scholte, W. F., Hollon, S. D., Chowdhary, N., Suryani, A. O., Bockting, C. L. H., Leerstoel Bockting, and Trauma and Grief
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LMIC ,Developing country ,Depression ,Indonesia ,Lay counseling ,Low and middle income country ,Psychological interventions ,Online therapy ,global mental health ,Medicine (miscellaneous) ,Pharmacology (medical) ,Behavioral activation ,Internet-based intervention - Abstract
Background: Depression is a leading cause of disease burden across the world. However, in low-middle income countries (LMICs), access to mental health services is severely limited because of the insufficient number of mental health professionals available. The WHO initiated the Mental Health Gap Action Program (mhGAP) aiming to provide a coherent strategy for closing the gap between what is urgently needed and what is available in LMICs. Internet-based treatment is a promising strategy that can be made available to a large number of people now that Internet access is increasing rapidly throughout the world. The present study will investigate whether such an Internet-based treatment for depression is effective in Indonesia. Methods: An Internet-based behavioral activation treatment, with support by lay counselors who will provide online feedback on the assignments and supportive phone contact to encourage participants to work in the program (Guided Act and Feel Indonesia/GAF-ID), is compared to an online-delivered minimal psychoeducation without any support (psychoeducation/PE). Initial assessment for inclusion is based on a Patient Health Questionnaire-9 (PHQ-9) score of at least 10 and meeting criteria for major depressive disorder or persistent depressive disorder as assessed using the Structured Clinical Interview for DSM-5 (SCID-5). Participants with depression (N=312) will be recruited and randomly assigned to GAF-ID or PE. Overall assessments will be done at baseline, post intervention (10 weeks from baseline) and follow-ups (3 months and 6 months from baseline). The primary outcome is the reduction of depression symptoms as measured by the PHQ-9 after 10 weeks from baseline. Discussion: To our knowledge, this is the first study in Indonesia that examines the effectiveness of an Internet-based intervention for depression in a randomized controlled trial. The hope is that it can serve as a starting point for bridging the mental health gap in Indonesia and other LMICs. Trial registration: Nederlands Trial Register ( www.trialregister.nl ): NTR5920 , registered on 1 July 2016.
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- 2016
22. The potential of low-intensity and online interventions for depression in low- and middle-income countries
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Bockting, C. L. H., Williams, A. D., Carswell, K., Grech, A. E., Leerstoel Bockting, Trauma and Grief, Leerstoel Bockting, and Trauma and Grief
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medicine.medical_specialty ,Psychological intervention ,Social Sciences ,Review ,internet interventions ,Controlled studies ,World health ,LMICs ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,Medicine ,e-Health Innovations ,030212 general & internal medicine ,Psychiatry ,interventions ,mobile health ,Depression (differential diagnoses) ,Interventions ,business.industry ,Depression ,Mental health ,030227 psychiatry ,minimal interventions ,Low and middle income countries ,Software deployment ,Mental health care ,business - Abstract
The World Health Organization (WHO) reports that low- and middle-income countries (LMICs) are confronted with a serious ‘mental health gap’, indicating an enormous disparity between the number of individuals in need of mental health care and the availability of professionals to provide such care (WHO in 2010). Traditional forms of mental health services (i.e. face-to-face, individualised assessments and interventions) are therefore not feasible. We propose three strategies for addressing this mental health gap: delivery of evidence-based, low-intensity interventions by non-specialists, the use of transdiagnostic treatment protocols, and strategic deployment of technology to facilitate access and uptake. We urge researchers from all over the world to conduct feasibility studies and randomised controlled studies on the effect of low-intensity interventions and technology supported (e.g. online) interventions in LMICs, preferably using an active control condition as comparison, to ensure we disseminate effective treatments in LMICs.
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- 2016
23. Non-fatal disease burden for subtypes of depressive disorder: population-based epidemiological study
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Biesheuvel-Leliefeld, K. E. M., Kok, G., Bockting, C. L. H., De Graaf, R., Ten Have, M., Van de Horst, H. E., Van Schaik, A. E. M., Van Marwijk, H. W., Smit, F., Leerstoel Bockting, and Trauma and Grief
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Subtypes ,Quality of life ,Depressive disorder ,Epidemiology ,Burden of disease - Abstract
Background Major depression is the leading cause of non-fatal disease burden. Because major depression is not a homogeneous condition, this study estimated the non-fatal disease burden for mild, moderate and severe depression in both single episode and recurrent depression. All estimates were assessed from an individual and a population perspective and presented as unadjusted, raw estimates and as estimates adjusted for comorbidity. Methods We used data from the first wave of the second Netherlands-Mental-Health-Survey-and-Incidence-Study (NEMESIS-2, n = 6646; single episode Diagnostic and Statistical Manual (DSM)-IV depression, n = 115; recurrent depression, n = 246). Disease burden from an individual perspective was assessed as ‘disability weight * time spent in depression’ for each person in the dataset. From a population perspective it was assessed as ‘disability weight * time spent in depression *number of people affected’. The presence of mental disorders was assessed with the Composite International Diagnostic Interview (CIDI) 3.0. Results Single depressive episodes emerged as a key driver of disease burden from an individual perspective. From a population perspective, recurrent depressions emerged as a key driver. These findings remained unaltered after adjusting for comorbidity. Conclusions The burden of disease differs between the subtype of depression and depends much on the choice of perspective. The distinction between an individual and a population perspective may help to avoid misunderstandings between policy makers and clinicians.
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- 2016
24. Non-fatal disease burden for subtypes of depressive disorder
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Biesheuvel-Leliefeld, K. E. M., Kok, G., Bockting, C. L. H., De Graaf, R., Ten Have, M., Van de Horst, H. E., Van Schaik, A. E. M., Van Marwijk, H. W., Smit, F., Leerstoel Bockting, Trauma and Grief, Clinical Psychology and Experimental Psychopathology, General practice, EMGO - Mental health, Psychiatry, Epidemiology and Data Science, Adult Psychiatry, APH - Mental Health, and Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep
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Adult ,Male ,Quality of life ,medicine.medical_specialty ,Pediatrics ,Epidemiology ,Population ,Social Sciences ,Netherlands/epidemiology ,Severity of Illness Index ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Cost of Illness ,Severity of illness ,medicine ,Humans ,030212 general & internal medicine ,education ,Psychiatry ,Depression (differential diagnoses) ,Disease burden ,Netherlands ,Subtypes ,education.field_of_study ,business.industry ,Depressive disorder ,Burden of disease ,Depressive Disorder/epidemiology ,medicine.disease ,Comorbidity ,030227 psychiatry ,Psychiatry and Mental health ,Female ,business ,Cohort study ,Research Article - Abstract
Background: Major depression is the leading cause of non-fatal disease burden. Because major depression is not a homogeneous condition, this study estimated the non-fatal disease burden for mild, moderate and severe depression in both single episode and recurrent depression. All estimates were assessed from an individual and a population perspective and presented as unadjusted, raw estimates and as estimates adjusted for comorbidity. Methods: We used data from the first wave of the second Netherlands-Mental-Health-Survey-and-Incidence-Study (NEMESIS-2, n = 6646; single episode Diagnostic and Statistical Manual (DSM)-IV depression, n = 115; recurrent depression, n = 246). Disease burden from an individual perspective was assessed as 'disability weight * time spent in depression' for each person in the dataset. From a population perspective it was assessed as 'disability weight * time spent in depression *number of people affected'. The presence of mental disorders was assessed with the Composite International Diagnostic Interview (CIDI) 3.0. Results: Single depressive episodes emerged as a key driver of disease burden from an individual perspective. From a population perspective, recurrent depressions emerged as a key driver. These findings remained unaltered after adjusting for comorbidity. Conclusions: The burden of disease differs between the subtype of depression and depends much on the choice of perspective. The distinction between an individual and a population perspective may help to avoid misunderstandings between policy makers and clinicians. © 2016 Biesheuvel-Leliefeld et al.
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- 2016
25. Stop or go?
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Molenaar, Nina, Brouwer, M. E., Bockting, C. L. H., Bonsel, G. J., Van der Veere, C. N., Torij, H. W., Hoogendijk, W., Duvekot, J. J., Burger, H. N., Lambregtse-van den Berg, M. P., Trauma and Grief, Leerstoel Bockting, Psychiatry, Obstetrics & Gynecology, Medical Oncology, Child and Adolescent Psychiatry / Psychology, Trauma and Grief, Leerstoel Bockting, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Public and occupational health, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Reproductive Origins of Adult Health and Disease (ROAHD), and Life Course Epidemiology (LCE)
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Pediatrics ,Cost effectiveness ,SEROTONIN REUPTAKE INHIBITORS ,medicine.medical_treatment ,POPULATION-BASED COHORT ,Social Sciences ,Antidepressive Agents/therapeutic use ,law.invention ,COST-EFFECTIVENESS ,Study Protocol ,0302 clinical medicine ,Randomized controlled trial ,Clinical Protocols ,law ,Recurrence ,Pregnancy ,Medicine and Health Sciences ,SSRI ,Depressive Disorder/drug therapy ,RECURRENT DEPRESSION ,030212 general & internal medicine ,Relapse ,Netherlands ,Psychomotor learning ,MAJOR DEPRESSIVE DISORDER ,Depression ,digestive, oral, and skin physiology ,GENERAL MOVEMENTS ,Antidepressants ,Antidepressive Agents ,Psychiatry and Mental health ,Prenatal Exposure Delayed Effects ,antidepressants ,Major depressive disorder ,Anxiety ,Female ,medicine.symptom ,Psychology ,MENTAL-HEALTH ,Adult ,medicine.medical_specialty ,Prenatal Exposure Delayed Effects/prevention & control ,MATERNAL DEPRESSION ,PRETERM BIRTH ,Cognitive therapy ,behavioral disciplines and activities ,03 medical and health sciences ,Selective serotonin reuptake inhibitors ,mental disorders ,medicine ,Humans ,study ,Psychiatry ,PRENATAL EXPOSURE ,Depressive Disorder ,Cognitive Behavioral Therapy ,Prevention ,Cognitive Behavioral Therapy/methods ,Perinatal outcome ,medicine.disease ,030227 psychiatry ,Discontinuation ,cognitive therapy ,Cost-effectiveness ,Serotonin Uptake Inhibitors/therapeutic use - Abstract
BACKGROUND: Approximately 6.2 % of women in the USA and 3.7 % of women in the UK, use Selective Serotonin Reuptake Inhibitors (SSRIs) during their pregnancies because of depression and/or anxiety. In the Netherlands, this prevalence is around 2 %. Nonetheless, SSRI use during pregnancy is still controversial. On the one hand SSRIs may be toxic to the intrauterine developing child, while on the other hand relapse or recurrence of depression during pregnancy poses risks for both mother and child. Among patients and professionals there is an urgent need for evidence from randomized studies to make rational decisions regarding continuation or tapering of SSRIs during pregnancy. At present, no such studies exist. METHODS/DESIGN: 'Stop or Go' is a pragmatic multicentre randomized non-inferiority trial among 200 pregnant women with a gestational age of less than 16 weeks who use SSRIs without clinically relevant depressive symptoms. Women allocated to the intervention group will receive preventive cognitive therapy with gradual, guided discontinuation of SSRIs under medical management (STOP). Women in the control group will continue the use of SSRIs (GO). Primary outcome will be the (cumulative) incidence of relapse or recurrence of maternal depressive disorder (as assessed by the Structured Clinical Interview for DSM disorders) during pregnancy and up to three months postpartum. Secondary outcomes will be child outcome (neonatal outcomes and psychomotor and behavioural outcomes up to 24 months postpartum), and health-care costs. Total study duration for participants will be therefore be 30 months. We specified a non-inferiority margin of 15 % difference in relapse risk. DISCUSSION: This study is the first to investigate the effect of guided tapering of SSRIs with preventive cognitive therapy from early pregnancy onwards as compared to continuation of SSRIs during pregnancy. We will study the effects on both mother and child with a pragmatic approach. Additionally, the study examines cost effectiveness. If non-inferiority of preventive cognitive therapy with guided tapering of SSRIs compared to intended continuation of SSRIs is demonstrated for the primary outcome, this may be the preferential strategy during pregnancy. TRIAL REGISTRATION: Netherlands Trial Register (NTR): NTR4694 ; registration date: 16-jul-2014.
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- 2016
26. Toward a Rational Model of Depression Treatment
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Forand, N. R., Richards, D. A., Marcus Huibers, Bockting, C. L. H., DeRubeis, R., and Strunk, D.
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- 2016
27. Implicit and Explicit Self-Esteem in Current, Remitted, Recovered, and Comorbid Depression and Anxiety Disorders: The NESDA Study
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Van Tuijl, L. A., Glashouwer, K. A., Bockting, C. L. H., Tendeiro, J. N., Penninx, B. W. J. H., De Jong, P. J., Leerstoel Bockting, and Trauma and Grief
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depression ,implicit association ,Explicit Attitudes ,co-morbidity ,self esteem ,anxiety - Abstract
BACKGROUND: Dual processing models of psychopathology emphasize the relevance of differentiating between deliberative self-evaluative processes (explicit self-esteem; ESE) and automatically-elicited affective self-associations (implicit self-esteem; ISE). It has been proposed that both low ESE and ISE would be involved in major depressive disorder (MDD) and anxiety disorders (AD). Further, it has been hypothesized that MDD and AD may result in a low ISE "scar" that may contribute to recurrence after remission. However, the available evidence provides no straightforward support for the relevance of low ISE in MDD/AD, and studies testing the relevance of discrepant SE even showed that especially high ISE combined with low ESE is predictive of the development of internalizing symptoms. However, these earlier findings have been limited by small sample sizes, poorly defined groups in terms of comorbidity and phase of the disorders, and by using inadequate indices of discrepant SE. Therefore, this study tested further the proposed role of ISE and discrepant SE in a large-scale study allowing for stricter differentiation between groups and phase of disorder. METHOD: In the context of the Netherlands Study of Depression and Anxiety (NESDA), we selected participants with current MDD (n = 60), AD (n = 111), and comorbid MDD/AD (n = 71), remitted MDD (n = 41), AD (n = 29), and comorbid MDD/AD (n = 14), recovered MDD (n = 136) and AD (n = 98), and never MDD or AD controls (n = 382). The Implicit Association Test was used to index ISE and the Rosenberg Self-Esteem Scale indexed ESE. RESULTS: Controls reported higher ESE than all other groups, and current comorbid MDD/AD had lower ESE than all other clinical groups. ISE was only lower than controls in current comorbid AD/MDD. Discrepant self-esteem (difference between ISE and ESE) was not associated with disorder status once controlling for ESE. LIMITATIONS: Cross-sectional design limits causal inferences. CONCLUSION: Findings suggest a prominent role for ESE in MDD and AD, while in comorbid MDD/AD negative self-evaluations are also present at the implicit level. There was no evidence to support the view that AD and MDD would result in a low ISE "scar".
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- 2016
28. Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study
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Mocking, R. J. T., Bockting, C. L. H., Figueroa, C. A., Rive, M. M., Geugies, H., Servaas, M. N., Assies, J., Koeter, M. W. J., Vaz, F.M., Wichers, M., Van Straalen, J. P., De Raedt, R., Harmer, C. J., Schene, A. H., Ruhé, H. G., Leerstoel Bockting, Trauma and Grief, Leerstoel Bockting, Trauma and Grief, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Adult Psychiatry, Graduate School, Amsterdam Public Health, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam Cardiovascular Sciences, Laboratory for General Clinical Chemistry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Other departments
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Magnetic Resonance Spectroscopy ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,Social Sciences ,law.invention ,0302 clinical medicine ,PREVENTIVE MEDICINE ,Randomized controlled trial ,Recurrence ,law ,NEGATIVE BOLD RESPONSES ,Protocol ,Longitudinal Studies ,Prospective Studies ,Default mode network ,Neuropsychology ,Brain ,DYSFUNCTIONAL ATTITUDE SCALE ,General Medicine ,MAGNETIC-RESONANCE-SPECTROSCOPY ,RANDOMIZED CONTROLLED-TRIAL ,Middle Aged ,Magnetic Resonance Imaging ,Mental Health ,Diffusion Tensor Imaging ,VOXEL-BASED MORPHOMETRY ,Research Design ,DEFAULT-MODE NETWORK ,Major depressive disorder ,PREVENTIVE COGNITIVE THERAPY ,PITUITARY-ADRENAL-AXIS ,Statistics & Research methods ,Cohort study ,Adult ,Experience sampling method ,medicine.medical_specialty ,behavioral disciplines and activities ,STATISTICS & RESEARCH METHODS ,03 medical and health sciences ,Neuroimaging ,mental disorders ,medicine ,Humans ,Psychiatry ,Aged ,Proportional Hazards Models ,Psychiatric Status Rating Scales ,Preventive medicine ,Depressive Disorder, Major ,business.industry ,STATE FUNCTIONAL CONNECTIVITY ,Repeated measures design ,medicine.disease ,030227 psychiatry ,Cross-Sectional Studies ,ANTERIOR CINGULATE CORTEX ,Case-Control Studies ,Linear Models ,business ,030217 neurology & neurosurgery - Abstract
Contains fulltext : 168271.pdf (Publisher’s version ) (Open Access) INTRODUCTION: Major depressive disorder (MDD) is widely prevalent and severely disabling, mainly due to its recurrent nature. A better understanding of the mechanisms underlying MDD-recurrence may help to identify high-risk patients and to improve the preventive treatment they need. MDD-recurrence has been considered from various levels of perspective including symptomatology, affective neuropsychology, brain circuitry and endocrinology/metabolism. However, MDD-recurrence understanding is limited, because these perspectives have been studied mainly in isolation, cross-sectionally in depressed patients. Therefore, we aim at improving MDD-recurrence understanding by studying these four selected perspectives in combination and prospectively during remission. METHODS AND ANALYSIS: In a cohort design, we will include 60 remitted, unipolar, unmedicated, recurrent MDD-participants (35-65 years) with >/=2 MDD-episodes. At baseline, we will compare the MDD-participants with 40 matched controls. Subsequently, we will follow-up the MDD-participants for 2.5 years while monitoring recurrences. We will invite participants with a recurrence to repeat baseline measurements, together with matched remitted MDD-participants. Measurements include questionnaires, sad mood-induction, lifestyle/diet, 3 T structural (T1-weighted and diffusion tensor imaging) and blood-oxygen-level-dependent functional MRI (fMRI) and MR-spectroscopy. fMRI focusses on resting state, reward/aversive-related learning and emotion regulation. With affective neuropsychological tasks we will test emotional processing. Moreover, we will assess endocrinology (salivary hypothalamic-pituitary-adrenal-axis cortisol and dehydroepiandrosterone-sulfate) and metabolism (metabolomics including polyunsaturated fatty acids), and store blood for, for example, inflammation analyses, genomics and proteomics. Finally, we will perform repeated momentary daily assessments using experience sampling methods at baseline. We will integrate measures to test: (1) differences between MDD-participants and controls; (2) associations of baseline measures with retro/prospective recurrence-rates; and (3) repeated measures changes during follow-up recurrence. This data set will allow us to study different predictors of recurrence in combination. ETHICS AND DISSEMINATION: The local ethics committee approved this study (AMC-METC-Nr.:11/050). We will submit results for publication in peer-reviewed journals and presentation at (inter)national scientific meetings. TRIAL REGISTRATION NUMBER: NTR3768.
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- 2016
29. Imagery rescripting : the impact of conceptual and perceptual changes on aversive autobiographical memories
- Author
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Slofstra, Christien, Nauta, Maaike H., Holmes, Emily A., Bockting, C. L. H., Leerstoel Bockting, Trauma and Grief, Leerstoel Bockting, Trauma and Grief, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Clinical Psychology and Experimental Psychopathology
- Subjects
Male ,050103 clinical psychology ,Mindfulness ,Eye Movements ,Physiology ,Visual System ,Emotions ,Sensory Physiology ,lcsh:Medicine ,Social Sciences ,Mental Recall/physiology ,Stress Disorders, Post-Traumatic ,POSTTRAUMATIC-STRESS-DISORDER ,Cognition ,Learning and Memory ,Recall (Memory) ,Affect/physiology ,Task Performance and Analysis ,Medicine and Health Sciences ,Psychology ,Imagery ,lcsh:Science ,Stress Disorders ,media_common ,Multidisciplinary ,Respiration ,05 social sciences ,PTSD ,COGNITIVE-BEHAVIOR THERAPY ,Sensory Systems ,Treatment Outcome ,Breathing ,Perception/physiology ,Female ,Anatomy ,Episodic ,Mental image ,Cognitive psychology ,Research Article ,Adult ,Vividness ,Imagery, Psychotherapy ,media_common.quotation_subject ,Cognitive Neuroscience ,Memory, Episodic ,050105 experimental psychology ,Stress Disorders, Post-Traumatic/psychology ,Young Adult ,WORKING-MEMORY ,Emotionality ,Memory ,Ocular System ,Perception ,Journal Article ,MENTAL-IMAGERY ,Humans ,PROLONGED EXPOSURE ,0501 psychology and cognitive sciences ,METAANALYSES ,Working Memory ,EMOTIONALITY ,Post-Traumatic/psychology ,Recall ,Autobiographical memory ,Working memory ,lcsh:R ,Biology and Life Sciences ,Psychotherapy ,Affect ,Mental Recall ,Cognitive Science ,Eyes ,lcsh:Q ,EYE-MOVEMENTS ,Physiological Processes ,Head ,Neuroscience - Abstract
BACKGROUND: Imagery rescripting (ImRs) is a process by which aversive autobiographical memories are rendered less unpleasant or emotional. ImRs is thought only to be effective if a change in the meaning-relevant (semantic) content of the mental image is produced, according to a cognitive hypothesis of ImRs. We propose an additional hypothesis: that ImRs can also be effective by the manipulation of perceptual features of the memory, without explicitly targeting meaning-relevant content.METHODS: In two experiments using a within-subjects design (both N = 48, community samples), both Conceptual-ImRs-focusing on changing meaning-relevant content-and Perceptual-ImRs-focusing on changing perceptual features-were compared to Recall-only of aversive autobiographical image-based memories. An active control condition, Recall + Attentional Breathing (Recall+AB) was added in the first experiment. In the second experiment, a Positive-ImRs condition was added-changing the aversive image into a positive image that was unrelated to the aversive autobiographical memory. Effects on the aversive memory's unpleasantness, vividness and emotionality were investigated.RESULTS: In Experiment 1, compared to Recall-only, both Conceptual-ImRs and Perceptual-ImRs led to greater decreases in unpleasantness, and Perceptual-ImRs led to greater decreases in emotionality of memories. In Experiment 2, the effects on unpleasantness were not replicated, and both Conceptual-ImRs and Perceptual-ImRs led to greater decreases in emotionality, compared to Recall-only, as did Positive-ImRs. There were no effects on vividness, and the ImRs conditions did not differ significantly from Recall+AB.CONCLUSIONS: Results suggest that, in addition to traditional forms of ImRs, targeting the meaning-relevant content of an image during ImRs, relatively simple techniques focusing on perceptual aspects or positive imagery might also yield benefits. Findings require replication and extension to clinical samples.
- Published
- 2016
30. Treating depressive symptoms in psychosis
- Author
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Steenhuis, L. A., Nauta, M. H., Bockting, C. L. H., Pijnenborg, G. H. M., Trauma and Grief, Leerstoel Bockting, and Clinical Psychology and Experimental Psychopathology
- Subjects
Occupational therapy ,EXERCISE THERAPY ,Psychosis ,medicine.medical_specialty ,Music therapy ,GROUP MUSIC-THERAPY ,YOGA THERAPY ,Social Sciences ,lcsh:Medicine ,NEGATIVE SYMPTOMS ,law.invention ,Randomized controlled trial ,Rating scale ,law ,Internal medicine ,SCHIZOPHRENIA ,medicine ,1ST-EPISODE PSYCHOSIS ,RATING-SCALE ,lcsh:Science ,Psychiatry ,Multidisciplinary ,business.industry ,lcsh:R ,RANDOMIZED CONTROLLED-TRIAL ,medicine.disease ,COGNITIVE-BEHAVIOR THERAPY ,Clinical trial ,Schizophrenia ,Meta-analysis ,lcsh:Q ,business ,FOLLOW-UP ,Research Article - Abstract
AIMS: The aim of this study was to examine whether non-verbal therapies are effective in treating depressive symptoms in psychotic disorders.MATERIAL AND METHODS: A systematic literature search was performed in PubMed, Psychinfo, Picarta, Embase and ISI Web of Science, up to January 2015. Randomized controlled trials (RCTs) comparing a non-verbal intervention to a control condition in patients with psychotic disorders, whilst measuring depressive symptoms as a primary or secondary outcome, were included. The quality of studies was assessed using the 'Clinical Trials Assessment Measure for psychological treatments' (CTAM) scale. Cohen's d was calculated as a measure of effect size. Using a Network Meta-analysis, both direct and indirect evidence was investigated.RESULTS: 10 RCTs were included, of which three were of high quality according to the CTAM. The direct evidence demonstrated a significant effect on the reduction in depressive symptoms relative to treatment as usual (TAU), in favor of overall non-verbal therapy (ES: -0.66, 95% C.I. = -0.88, -0.44) and music therapy (ES: -0.59, 95% C.I. = -0.85, -0.33). Combining both direct and indirect evidence, yoga therapy (ES: -0.79, 95% C.I. = -1.24, -0.35) had a significant effect on depressive symptoms, and occupational therapy (ES: 1.81, 95% C.I. = 0.81, 2.81) was less effective, relative to TAU. Exercise therapy did not show a significant effect on depressive symptoms in comparison to TAU (ES: -0.02 95% C.I. = -0.67, 0.62). Due to inconsistency of study evidence, the indirect effects should be interpreted cautiously.CONCLUSIONS: Non-verbal therapies appear to be effective in reducing depressive symptomatology in psychotic disorders, in particular music therapy and yoga therapy.
- Published
- 2015
31. Cognitive reactivity, self-depressed associatons, and the recurrence of depression
- Author
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Elgersma, H. J., De Jong, P. J., Van Rijsbergen, G. D., Kok, G. D., Burger, H., Van Der Does, W., Penninx, Brenda W J H, Bockting, C. L. H., Trauma and Grief, Leerstoel Bockting, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Psychiatry, EMGO - Mental health, Trauma and Grief, Leerstoel Bockting, Clinical Psychology and Experimental Psychopathology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Reproductive Origins of Adult Health and Disease (ROAHD), Life Course Epidemiology (LCE), and EMGO+ - Mental Health
- Subjects
Male ,CONCEPTUAL ANALYSIS ,PREDICTION ,Cross-sectional study ,RELAPSE ,Cohort Studies ,Cognition ,Risk Factors ,Recurrence ,Adaptation, Psychological ,ANXIETY ,Young adult ,Depression (differential diagnoses) ,Internal-External Control ,Netherlands ,Depression ,Implicit-association test ,Implicit self-association ,Psychiatry and Mental health ,Clinical Psychology ,SAD MOOD ,Anxiety ,key2 ,Female ,key3 ,medicine.symptom ,Psychology ,Cohort study ,Adult ,medicine.medical_specialty ,DISORDERS ,Vulnerability ,Affect (psychology) ,Young Adult ,SDG 3 - Good Health and Well-being ,IMPLICIT ,medicine ,Humans ,Adaptation ,Risk factor ,Psychiatry ,Cognitive reactivity ,Keywords ,INDIVIDUALS ,Affect ,Cross-Sectional Studies ,Remitted ,Psychological ,Depression/psychology ,Keywords, key2, key3 - Abstract
Background: Mixed evidence exists regarding the role of cognitive reactivity (CR; cognitive responsivity to a negative mood) as a risk factor for recurrences of depression. One explanation for the mixed evidence may lie in the number of previous depressive episodes. Heightened CR may be especially relevant as a risk factor for the development of multiple depressive episodes and less so for a single depressive episode. In addition, it is theoretically plausible but not yet tested that the relationship between CR and number of episodes is moderated by the strength of automatic depression-related self-associations.Aim: To investigate (i) the strength of CR in remitted depressed individuals with a history of a single vs. multiple episodes, and (ii) the potentially moderating role of automatic negative self-associations in the relationship between the number of episodes and CR.Method: Cross-sectional analysis of data obtained in a cohort study (Study 1) and during baseline assessments in two clinical trials (Study 2). Study 1 used data from the Netherlands Study of Depression and Anxiety (NESDA) and compared never-depressed participants (n=901) with remitted participants with either a single (n=336) or at least 2 previous episodes (n=273). Study 2 included only remitted participants with at least two previous episodes (n=273). The Leiden Index of Depression Sensitivity Revised (LEIDS-R) was used to index CR and an Implicit Association Test (IAT) to measure implicit self-associations.Results: In Study 1, remitted depressed participants with multiple episodes had significantly higher CR than those with a single or no previous episode. The remitted individuals with multiple episodes of Study 2 had even higher CR scores than those of Study 1. Within the group of individuals with multiple episodes, CR was not heightened as a function of the number of episodes, even if individual differences in automatic negative sell associations were taken into account. Limitations: The study employed a cross-sectional design, which precludes a firm conclusion with regard to the direction of this relationship.Conclusions: The findings are consistent with the view that high CR puts people at risk for recurrent depression and is less relevant for the development of an incidental depressive episode. This suggests that CR is an important target for interventions that aim to prevent the recurrence of depression. (C) 2015 Elsevier By. All rights reserved.
- Published
- 2015
32. Treating depressive symptoms in psychosis: A Network Meta-Analysis on the Effects of Non-Verbal Therapies
- Author
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Steenhuis, L. A., Nauta, M. H., Bockting, C. L. H., Pijnenborg, G. H. M., Trauma and Grief, and Leerstoel Bockting
- Abstract
AIMS: The aim of this study was to examine whether non-verbal therapies are effective in treating depressive symptoms in psychotic disorders. MATERIAL AND METHODS: A systematic literature search was performed in PubMed, Psychinfo, Picarta, Embase and ISI Web of Science, up to January 2015. Randomized controlled trials (RCTs) comparing a non-verbal intervention to a control condition in patients with psychotic disorders, whilst measuring depressive symptoms as a primary or secondary outcome, were included. The quality of studies was assessed using the 'Clinical Trials Assessment Measure for psychological treatments' (CTAM) scale. Cohen's d was calculated as a measure of effect size. Using a Network Meta-analysis, both direct and indirect evidence was investigated. RESULTS: 10 RCTs were included, of which three were of high quality according to the CTAM. The direct evidence demonstrated a significant effect on the reduction in depressive symptoms relative to treatment as usual (TAU), in favor of overall non-verbal therapy (ES: -0.66, 95% C.I. = -0.88, -0.44) and music therapy (ES: -0.59, 95% C.I. = -0.85, -0.33). Combining both direct and indirect evidence, yoga therapy (ES: -0.79, 95% C.I. = -1.24, -0.35) had a significant effect on depressive symptoms, and occupational therapy (ES: 1.81, 95% C.I. = 0.81, 2.81) was less effective, relative to TAU. Exercise therapy did not show a significant effect on depressive symptoms in comparison to TAU (ES: -0.02 95% C.I. = -0.67, 0.62). Due to inconsistency of study evidence, the indirect effects should be interpreted cautiously. CONCLUSIONS: Non-verbal therapies appear to be effective in reducing depressive symptomatology in psychotic disorders, in particular music therapy and yoga therapy.
- Published
- 2015
33. DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence?
- Author
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Mocking, R. J. T., Pellikaan, C. M., Lok, A., Assies, J., Ruhé, H. G., Koeter, M. W., Visser, I., Bockting, C. L. H., Olff, M., Schene, A. H., Trauma and Grief, Leerstoel Bockting, Trauma and Grief, Leerstoel Bockting, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Psychology and Experimental Psychopathology, ANS - Amsterdam Neuroscience, Graduate School, Adult Psychiatry, APH - Amsterdam Public Health, and Other departments
- Subjects
Male ,DISORDER ,SALIVARY CORTISOL ,STRESS ,Hydrocortisone ,medicine.medical_treatment ,Endocrinology, Diabetes and Metabolism ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,Pituitary-Adrenal System ,Cortisol ,chemistry.chemical_compound ,Endocrinology ,Recurrence ,ADOLESCENTS ,polycyclic compounds ,Longitudinal Studies ,BRAIN ,skin and connective tissue diseases ,Depression (differential diagnoses) ,Hypothalamic-pituitary-adrenal (HPA) axis ,Morning ,Major depressive disorder (MDD) ,Dehydroepiandrosterone Sulfate ,Middle Aged ,Diabetes and Metabolism ,Psychiatry and Mental health ,Treatment Outcome ,Trait ,Major depressive disorder ,Female ,Biological psychiatry ,Psychology ,hormones, hormone substitutes, and hormone antagonists ,Adult ,medicine.medical_specialty ,Hypothalamo-Hypophyseal System ,endocrine system ,Evening ,PLASMA-CONCENTRATIONS ,Remission ,DEHYDROEPIANDROSTERONE-SULFATE ,Dehydroepiandrosterone sulfate ,Predictive Value of Tests ,Internal medicine ,PSYCHOTHERAPY ,Dehydroepiandrosterone-sulphate (DHEAS) ,medicine ,Humans ,Saliva ,Biological Psychiatry ,Depressive Disorder, Major ,Cognitive Behavioral Therapy ,Endocrine and Autonomic Systems ,COGNITIVE THERAPY ,MAJOR DEPRESSION ,medicine.disease ,Cross-Sectional Studies ,chemistry ,Case-Control Studies ,Cognitive therapy ,human activities - Abstract
Item does not contain fulltext BACKGROUND: Major depressive disorder (MDD) has been associated with low dehydroepiandrosterone-sulphate (DHEAS), - particularly relative to high cortisol - although conflicting findings exist. Moreover, it is unclear whether low DHEAS is only present during the depressive state, or manifests as a trait that may reflect vulnerability for recurrence. Therefore, we longitudinally tested whether low DHEAS and high cortisol/DHEAS-ratio in recurrent MDD (I) reflects a trait, and/or (II) varies with depressive state. In addition, we tested associations with (III) previous MDD-episodes, (IV) prospective recurrence, and (V) effects of cognitive therapy. METHODS: At study-entry, we cross-sectionally compared morning and evening salivary DHEAS and molar cortisol/DHEAS-ratio of 187 remitted recurrent MDD-patients with 72 matched controls. Subsequently, patients participated in an 8-week randomized controlled cognitive therapy trial. We repeated salivary measures after 3 months and 2 years. We measured clinical symptoms during a 10-year follow-up. RESULTS: Remitted patients showed steeper diurnal DHEAS-decline (p
- Published
- 2015
34. Preventive Cognitive Therapy versus Treatment as Usual in preventing recurrence of depression: Protocol of a multi-centered randomized controlled trial
- Author
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De Jonge, M., Bockting, C. L. H., Kikkert, M. J., Bosmans, J. E., Dekker, J. J. M., Trauma and Grief, Leerstoel Bockting, Trauma and Grief, Leerstoel Bockting, Health Economics and Health Technology Assessment, Clinical Psychology, EMGO+ - Mental Health, Clinical Psychology and Experimental Psychopathology, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Graduate School
- Subjects
Adult ,medicine.medical_specialty ,Pediatrics ,medicine.medical_treatment ,Cost-Benefit Analysis ,Psychological intervention ,Social Sciences ,law.invention ,Study Protocol ,Randomized controlled trial ,Clinical Protocols ,SDG 3 - Good Health and Well-being ,law ,Recurrence ,medicine ,Depressive Disorder, Major/prevention & control ,Secondary Prevention ,Humans ,Relapse ,Psychiatry ,Major depressive episode ,Depression (differential diagnoses) ,Depressive Disorder ,Depressive Disorder, Major ,Cognitive Behavioral Therapy ,Depression ,Prevention ,Cost-effectiveness analysis ,medicine.disease ,Cognitive behavioral therapy ,Psychiatry and Mental health ,Treatment Outcome ,Cognitive Therapy ,Cognitive therapy ,Major depressive disorder ,medicine.symptom ,Psychology ,Major/prevention & control - Abstract
BackgroundMajor depressive disorder (MDD) is projected to rank second on a list of 15 major diseases in terms of burden in 2030. The contribution of MDD to disability and health care costs is largely due to its highly recurrent nature. Therefore, part of the efforts to reduce the disabling effects of depression should focus on preventing recurrence, especially in patients at high risk of recurrence. The best established effective psychological intervention is cognitive therapy, with indications for prophylactic effects after remission.Methods/DesignIn this randomized controlled trial (cost-) effectiveness of Preventive Cognitive Therapy (PCT) after response to Acute Cognitive Therapy (A-CT) will be evaluated in comparison with Treatment As Usual (TAU). Remitted patients that responded to A-CT treatment with at least two previous depressive episodes will be recruited. Randomization will be stratified for number of previous episodes. Follow-ups are at 3, 6, 12 and 15 months. The primary outcome measure will be the time to relapse or recurrence of depression meeting DSM-IV criteria for a major depressive episode on the Structured Clinical Interview for DSM-VI Axis I Disorders (SCID-I). Costs will be measured from a societal perspective.DiscussionThis study is the first to examine the addition of PCT to TAU, compared to TAU alone in patients that recovered from depressive disorder with A-CT. Alongside this effect study a cost effectiveness analysis will be conducted. Furthermore, the study explores potential moderators to examine what works for whom.Trial registrationNetherlands Trial Register (NTR): 2599, date of registration: 11-11-2010.KeywordsDepression Relapse Recurrence Cognitive Therapy Prevention
- Published
- 2015
35. Network destabilization and transition in depression: New methods for studying the dynamics of therapeutic change
- Author
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Hayes, A. M., Yasinski, C., Ben Barnes, J., Bockting, C. L. H., Trauma and Grief, Leerstoel Bockting, and Universiteit Utrecht
- Subjects
Cognitive change in depression ,Psychiatry and Mental health ,Clinical Psychology ,Depression ,Chronic depression ,Emotional processing ,Dynamic systems theory - Abstract
The science of dynamic systems is the study of pattern formation and system change. Dynamic systems theory can provide a useful framework for understanding the chronicity of depression and its treatment. We propose a working model of therapeutic change with potential to organize findings from psychopathology and treatment research, suggest new ways to study change, facilitate comparisons across studies, and stimulate treatment innovation. We describe a treatment for depression that we developed to apply principles from dynamic systems theory and then present a program of research to examine the utility of this application. Recent methodological and technological developments are also discussed to further advance the search for mechanisms of therapeutic change.
- Published
- 2015
36. Pregnancy outcomes after a Maternity Intervention for Stressful Emotions (PROMISES)
- Author
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Burger, H., Bockting, C. L. H., Beijers, C., Verbeek, T., Stant, A. D., Ormel, J., Stolk, R. P., De Jonge, P., Van Pampus, M. G., Meijer, J., Antonelli, Marta C., Trauma and Grief, Leerstoel Bockting, Clinical Psychology and Experimental Psychopathology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Reproductive Origins of Adult Health and Disease (ROAHD), Life Course Epidemiology (LCE), and Lifestyle Medicine (LM)
- Subjects
medicine.medical_specialty ,ANXIETY DISORDERS ,Post traumatic stress disorder (PTSD) ,Cognitive behavioural therapy ,Anxiety ,ANTENATAL CARE ,law.invention ,Randomized controlled trial ,law ,Pregnancy ,medicine ,Psychiatry ,Child development ,Post-traumatic stress disorder (PTSD) ,Transdiagnostic factor ,Public health ,medicine.disease ,Mental health ,Neonatal outcomes ,depression ,medicine.symptom ,Psychology ,Psychosocial ,Clinical psychology - Abstract
UNLABELLED: There is ample evidence from observational prospective studies that maternal depression or anxiety during pregnancy is a risk factor for adverse psychosocial outcomes in the offspring. However, to date no previous study has demonstrated that treatment of depressive or anxious symptoms in pregnancy actually could prevent psychosocial problems in children. Preventing psychosocial problems in children will eventually bring down the huge public health burden of mental disease. The main objective of this study is to assess the effects of cognitive behavioural therapy in pregnant women with symptoms of anxiety or depression on the child's development as well as behavioural and emotional problems. In addition, we aim to study its effects on the child's development, maternal mental health, and neonatal outcomes, as well as the cost-effectiveness of cognitive behavioural therapy relative to usual care.We will include 300 women with at least moderate levels of anxiety or depression at the end of the first trimester of pregnancy. By including 300 women, we will be able to demonstrate effect sizes of 0.35 or more on the total problems scale of the Child Behaviour Checklist 1.5-5 with alpha 5 % and power (1-beta) 80 %.Women in the intervention arm are offered 10-14 individual cognitive behavioural therapy sessions, 6-10 sessions during pregnancy and 4-8 sessions after delivery (once a week). Women in the control group receive care as usual.Primary outcome is behavioural/emotional problems at 1.5 years of age as assessed by the total problems scale of the Child Behaviour Checklist 1.5-5 years.Secondary outcomes are mental, psychomotor and behavioural development of the child at age 18 months according to the Bayley scales; maternal anxiety and depression during pregnancy and postpartum; and neonatal outcomes such as birth weight, gestational age and Apgar score, health-care consumption and general health status (economic evaluation).TRIAL REGISTRATION: NTR2242.
- Published
- 2015
37. Pregnancy Outcomes After a Maternity Intervention for Stressful Emotions (PROMISES): A Randomised Controlled Trial
- Author
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Burger, H., Bockting, C. L. H., Beijers, C., Verbeek, T., Stant, A. D., Ormel, J., Stolk, R. P., De Jonge, P., Van Pampus, M. G., Meijer, J., Antonelli, Marta C., Trauma and Grief, and Leerstoel Bockting
- Subjects
Neonatal outcomes ,Pregnancy ,Depression ,Cognitive behavioural therapy ,Anxiety ,Child development - Abstract
There is ample evidence from observational prospective studies that maternal depression or anxiety during pregnancy is a risk factor for adverse psychosocial outcomes in the offspring. However, to date no previous study has demonstrated that treatment of depressive or anxious symptoms in pregnancy actually could prevent psychosocial problems in children. Preventing psychosocial problems in children will eventually bring down the huge public health burden of mental disease. The main objective of this study is to assess the effects of cognitive behavioural therapy in pregnant women with symptoms of anxiety or depression on the child’s development as well as behavioural and emotional problems. In addition, we aim to study its effects on the child’s development, maternal mental health, and neonatal outcomes, as well as the cost-effectiveness of cognitive behavioural therapy relative to usual care. We will include 300 women with at least moderate levels of anxiety or depression at the end of the first trimester of pregnancy. By including 300 women, we will be able to demonstrate effect sizes of 0.35 or more on the total problems scale of the Child Behaviour Checklist 1.5–5 with alpha 5 % and power (1-beta) 80 %. Women in the intervention arm are offered 10–14 individual cognitive behavioural therapy sessions, 6–10 sessions during pregnancy and 4–8 sessions after delivery (once a week). Women in the control group receive care as usual. Primary outcome is behavioural/emotional problems at 1.5 years of age as assessed by the total problems scale of the Child Behaviour Checklist 1.5–5 years. Secondary outcomes are mental, psychomotor and behavioural development of the child at age 18 months according to the Bayley scales; maternal anxiety and depression during pregnancy and postpartum; and neonatal outcomes such as birth weight, gestational age and Apgar score, health-care consumption and general health status (economic evaluation). Trial Registration: NTR2242
- Published
- 2015
38. Stop or go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial
- Author
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Trauma and Grief, Leerstoel Bockting, Molenaar, Nina, Brouwer, M. E., Bockting, C. L. H., Bonsel, G. J., Van der Veere, C. N., Torij, H. W., Hoogendijk, W., Duvekot, J. J., Burger, H. N., Lambregtse-van den Berg, M. P., Trauma and Grief, Leerstoel Bockting, Molenaar, Nina, Brouwer, M. E., Bockting, C. L. H., Bonsel, G. J., Van der Veere, C. N., Torij, H. W., Hoogendijk, W., Duvekot, J. J., Burger, H. N., and Lambregtse-van den Berg, M. P.
- Published
- 2016
39. Emotion regulation mediates the effect of childhood trauma on depression
- Author
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Leerstoel Bockting, Trauma and Grief, Hopfinger, Lisa, Bockting, C. L. H., Berking, Matthias, Ebert, David D., Leerstoel Bockting, Trauma and Grief, Hopfinger, Lisa, Bockting, C. L. H., Berking, Matthias, and Ebert, David D.
- Published
- 2016
40. The potential of low-intensity and online interventions for depression in low- and middle-income countries
- Author
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Leerstoel Bockting, Trauma and Grief, Bockting, C. L. H., Williams, A. D., Carswell, K., Grech, A. E., Leerstoel Bockting, Trauma and Grief, Bockting, C. L. H., Williams, A. D., Carswell, K., and Grech, A. E.
- Published
- 2016
41. Employment status, difficulties at work and quality of life in inflammatory bowel disease patients
- Author
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Leerstoel Bockting, Trauma and Grief, De Boer, A. G., Bockting, C. L. H., Bennebroek Evertsz', F., Stokkers, P. C., Sandeman, R., Hommes, D. W., Sprangers, M. A. G., Frings-Dresen, M. H. W., Leerstoel Bockting, Trauma and Grief, De Boer, A. G., Bockting, C. L. H., Bennebroek Evertsz', F., Stokkers, P. C., Sandeman, R., Hommes, D. W., Sprangers, M. A. G., and Frings-Dresen, M. H. W.
- Published
- 2016
42. Imagery rescripting: The impact of conceptual and perceptual changes on aversive autobiographical memories
- Author
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Leerstoel Bockting, Trauma and Grief, Slofstra, Christien, Nauta, Maaike H., Holmes, Emily A., Bockting, C. L. H., Leerstoel Bockting, Trauma and Grief, Slofstra, Christien, Nauta, Maaike H., Holmes, Emily A., and Bockting, C. L. H.
- Published
- 2016
43. Guided Act and Feel Indonesia (GAF-ID) - Internet-based behavioral activation intervention for depression in Indonesia: Study protocol for a randomized controlled trial
- Author
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Leerstoel Bockting, Trauma and Grief, Arjadi, R., Nauta, M. H., Scholte, W. F., Hollon, S. D., Chowdhary, N., Suryani, A. O., Bockting, C. L. H., Leerstoel Bockting, Trauma and Grief, Arjadi, R., Nauta, M. H., Scholte, W. F., Hollon, S. D., Chowdhary, N., Suryani, A. O., and Bockting, C. L. H.
- Published
- 2016
44. Implicit and Explicit Self-Esteem in Current, Remitted, Recovered, and Comorbid Depression and Anxiety Disorders: The NESDA Study
- Author
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Leerstoel Bockting, Trauma and Grief, Van Tuijl, L. A., Glashouwer, K. A., Bockting, C. L. H., Tendeiro, J. N., Penninx, B. W. J. H., De Jong, P. J., Leerstoel Bockting, Trauma and Grief, Van Tuijl, L. A., Glashouwer, K. A., Bockting, C. L. H., Tendeiro, J. N., Penninx, B. W. J. H., and De Jong, P. J.
- Published
- 2016
45. Non-fatal disease burden for subtypes of depressive disorder: population-based epidemiological study
- Author
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Leerstoel Bockting, Trauma and Grief, Biesheuvel-Leliefeld, K. E. M., Kok, G., Bockting, C. L. H., De Graaf, R., Ten Have, M., Van de Horst, H. E., Van Schaik, A. E. M., Van Marwijk, H. W., Smit, F., Leerstoel Bockting, Trauma and Grief, Biesheuvel-Leliefeld, K. E. M., Kok, G., Bockting, C. L. H., De Graaf, R., Ten Have, M., Van de Horst, H. E., Van Schaik, A. E. M., Van Marwijk, H. W., and Smit, F.
- Published
- 2016
46. Vulnerability for new episodes in recurrent major depressive disorder: Protocol for the longitudinal DELTA-neuroimaging cohort study
- Author
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Leerstoel Bockting, Trauma and Grief, Mocking, R. J. T., Bockting, C. L. H., Figueroa, C. A., Rive, M. M., Geugies, H., Servaas, M. N., Assies, J., Koeter, M. W. J., Vaz, F.M., Wichers, M., Van Straalen, J. P., De Raedt, R., Harmer, C. J., Schene, A. H., Ruhé, H. G., Leerstoel Bockting, Trauma and Grief, Mocking, R. J. T., Bockting, C. L. H., Figueroa, C. A., Rive, M. M., Geugies, H., Servaas, M. N., Assies, J., Koeter, M. W. J., Vaz, F.M., Wichers, M., Van Straalen, J. P., De Raedt, R., Harmer, C. J., Schene, A. H., and Ruhé, H. G.
- Published
- 2016
47. The role of avoidant and obsessive-compulsive personality disorder traits in matching patients with major depression to cognitive behavioral and psychodynamic therapy: A replication study
- Author
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Leerstoel Bockting, Trauma and Grief, Kikkert, M. J., Driessen, E., Peen, J., Barber, J. P., Bockting, C. L. H., Schalkwijk, F., Dekker, J., Dekker, J. J. M., Leerstoel Bockting, Trauma and Grief, Kikkert, M. J., Driessen, E., Peen, J., Barber, J. P., Bockting, C. L. H., Schalkwijk, F., Dekker, J., and Dekker, J. J. M.
- Published
- 2016
48. The role of avoidant and obsessive-compulsive personality disorder traits in matching patients with major depression to cognitive behavioral and psychodynamic therapy: A replication study
- Author
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Trauma and Grief, Leerstoel Bockting, Kikkert, M. J., Driessen, E., Peen, J., Barber, J. P., Bockting, C. L. H., Schalkwijk, F., Dekker, J., Dekker, J. J. M., Trauma and Grief, Leerstoel Bockting, Kikkert, M. J., Driessen, E., Peen, J., Barber, J. P., Bockting, C. L. H., Schalkwijk, F., Dekker, J., and Dekker, J. J. M.
- Published
- 2016
49. Associations of life events during pregnancy with longitudinal change in symptoms of antenatal anxiety and depression
- Author
-
Meijer, J. L., Bockting, C. L. H., Stolk, R. P., Kotov, R., Ormel, J., Burger, H., Trauma and Grief, SGPL Economische Geografie, Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Clinical Psychology and Experimental Psychopathology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Reproductive Origins of Adult Health and Disease (ROAHD), and Lifestyle Medicine (LM)
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,DISORDERS ,Depression/epidemiology ,Population ,Behavioral Symptoms ,Anxiety ,STRESSORS ,Life Change Events ,Young Adult ,CHILD ,Pregnancy ,Maternity and Midwifery ,medicine ,Humans ,COHORT ,Pregnancy/psychology ,Psychiatry ,education ,Depression (differential diagnoses) ,SCALE ,POPULATION ,education.field_of_study ,Depression ,Obstetrics and Gynecology ,WOMEN ,Middle Aged ,medicine.disease ,Neuroticism ,STATE ,Edinburgh Postnatal Depression Scale ,Female ,medicine.symptom ,Psychology ,Psychosocial ,State-Trait Anxiety Inventory ,Anxiety/epidemiology ,Clinical psychology - Abstract
OBJECTIVE: to investigate the association of life events during pregnancy with change in antenatal anxiety and depression symptoms. We distinguished pregnancy related and non-pregnancy related events and assessed specificity of these associations for depressive or anxious symptoms. In addition, we investigated whether the associations were affected by personality or childhood adversities.DESIGN: observational prospective cohort studySETTING: primary and secondary obstetric care centres in the NetherlandsPARTICIPANTS: 1603 women during their first trimester of pregnancy between May 2010 and May 2012 MEASUREMENTS AND FINDINGS: we performed linear regression analyses to test the associations of pregnancy related, non-pregnancy related life events, childhood adversities and the personality traits neuroticism and extraversion with the change in symptoms of anxiety (State Trait Anxiety Inventory) and depression (Edinburgh Postnatal Depression Scale) from week 12 to week 36. Life events during pregnancy were associated with increasing antenatal symptoms of anxiety and depression. Effect sizes associated with the highest numbers of events observed ranged from 0.59 to 1.31. Pregnancy related events were specifically associated with increasing symptoms of anxiety (p=0.009), whereas non-pregnancy related events were merely associated with an increase in symptoms of depression (pKEY CONCLUSIONS: the most important finding is that pregnancy related life events during pregnancy increase levels of antenatal anxiety, whereas depression levels increase when women experience life events that are unrelated to pregnancy. Furthermore, non-pregnancy related events show stronger associations with increases in symptoms of anxiety or depression compared to pregnancy related events.IMPLICATIONS FOR PRACTICE: our findings may help midwives to tailor psychosocial care to the specific risks of the pregnant woman which may eventually have a positive impact on the health of mother and child.
- Published
- 2014
50. Stressful Events and Continued Smoking and Continued Alcohol Consumption during Mid-Pregnancy
- Author
-
Beijers, C., Ormel, J., Meijer, J. L., Verbeek, T., Bockting, C. L. H., Burger, H., Trauma and Grief, SGPL Economische Geografie, Trauma and Grief, SGPL Economische Geografie, Clinical Psychology and Experimental Psychopathology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Reproductive Origins of Adult Health and Disease (ROAHD), and Life Course Epidemiology (LCE)
- Subjects
Cross-sectional study ,Epidemiology ,Emotions ,Social Sciences ,Anxiety ,Global Health ,Social and Behavioral Sciences ,Habits ,Pregnancy ,Surveys and Questionnaires ,TRAIT ANXIETY ,Psychology ,Prospective Studies ,Netherlands ,Psychiatry ,education.field_of_study ,Multidisciplinary ,Depression ,HEALTH BEHAVIORS ,Smoking ,Substance Abuse ,WOMEN ,Obstetrics and Gynecology ,Anxiety Disorders ,Mental Health ,Medicine ,Female ,Public Health ,medicine.symptom ,Alcohol ,Behavioral and Social Aspects of Health ,MENTAL DISTRESS ,Research Article ,Adult ,medicine.medical_specialty ,Tobacco Control ,Alcohol Drinking ,Science ,Population ,Psychological Stress ,Life Change Events ,Social support ,PRENATAL SMOKING ,medicine ,Humans ,education ,NEGATIVE LIFE EVENTS ,Behavior ,business.industry ,MATERNAL CIGARETTE-SMOKING ,Mood Disorders ,Odds ratio ,medicine.disease ,Social Epidemiology ,Cross-Sectional Studies ,Edinburgh Postnatal Depression Scale ,RISK-FACTORS ,Women's Health ,CESSATION ,Pregnant Women ,business ,SOCIAL SUPPORT ,State-Trait Anxiety Inventory ,Stress, Psychological - Abstract
Aimto examine whether the severity of different categories of stressful events is associated with continued smoking and alcohol consumption during mid-pregnancy. Also, we explored the explanation of these associations by anxiety and depressive symptoms during pregnancy. Finally, we studied whether the severity of stressful events was associated with the amount of cigarettes and alcohol used by continued users.MethodWe conducted a cross-sectional analysis using data from a population-based prospective cohort study. Pregnant women were recruited via midwifery practices throughout The Netherlands. We analyzed women who continued smoking (n = 113) or quit (n = 290), and women who continued alcohol consumption (n = 124) or quit (n = 1403) during pregnancy. Smoking, alcohol consumption, and perceived severity of stressful events were measured at 19 weeks of gestation. The State Trait Anxiety Inventory and the Edinburgh Postnatal Depression Scale were filled out at 14 weeks of gestation. Odds ratios were calculated as association measures and indicated the relative increase for the odds of continuation of smoking and alcohol consumption for the maximum severity score compared to the minimum score.FindingsSeverity of the following stressful event categories was associated with continued alcohol consumption: 'conflict with loved ones' (OR = 10.4, pConclusionsOur findings may be relevant for health care providers, in particular midwives and general practitioners. The impact of stressful events may be considered when advising pregnant women on smoking and alcohol consumption.
- Published
- 2014
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