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3,305 results on '"Bode, Christoph"'

3. Experimental end-to-end demonstration of intersatellite absolute ranging for LISA

Author

Yamamoto, Kohei, Bykov, Iouri, Reinhardt, Jan Niklas, Bode, Christoph, Grafe, Pascal, Staab, Martin, Messied, Narjiss, Clark, Myles, Barranco, Germán Fernández, Schwarze, Thomas S., Hartwig, Olaf, Delgado, Juan José Esteban, and Heinzel, Gerhard

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Laser Interferometer Space Antenna (LISA) is a gravitational wave detector in space. It relies on a post-processing technique named time-delay interferometry (TDI) to suppress the overwhelming laser frequency noise by several orders of magnitude. This algorithm requires intersatellite-ranging monitors to provide information on spacecraft separations. To fulfill this requirement, we will use on-ground observatories, optical sideband-sideband beatnotes, pseudo-random noise ranging (PRNR), and time-delay interferometric ranging (TDIR). This article reports on the experimental end-to-end demonstration of a hexagonal optical testbed used to extract absolute ranges via the optical sidebands, PRNR, and TDIR. These were applied for clock synchronization of optical beatnote signals sampled at independent phasemeters. We set up two possible PRNR processing schemes: Scheme 1 extracts pseudoranges from PRNR via a calibration relying on TDIR; Scheme 2 synchronizes all beatnote signals without TDIR calibration. The schemes rely on newly implemented monitors of local PRNR biases. After the necessary PRNR treatments (unwrapping, ambiguity resolution, bias correction, in-band jitter reduction, and/or calibration), Scheme 1 and 2 achieved ranging accuracies of 2.0 cm to 8.1 cm and 5.8 cm to 41.1 cm, respectively, below the classical 1 m mark with margins., Comment: 17 pages, 13 figures

Published
2024

5. Low on-clopidogrel ADP- and TRAP-6-induced platelet aggregation in patients with atrial fibrillation undergoing percutaneous coronary intervention: an observational pilot study

Author

Gjermeni, Diona, Anfang, Viktoria, Vetter, Hannah, Szabó, Sofia, Hesselbarth, David, Gauchel, Nadine, Siegel, Patrick M., Kaier, Klaus, Kille, Alexander, Franke, Kilian, Leggewie, Stefan, Trenk, Dietmar, Duerschmied, Daniel, Bode, Christoph, Westermann, Dirk, and Olivier, Christoph B.

Published
2024
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7. Future Narratives: Theory, Poetics, and Media-Historical Moment

Author

Bode, Christoph and Dietrich, Rainer

Subjects
Future, Narratives, Narratology, bic Book Industry Communication::D Literature & literary studies::DS Literature: history & criticism::DSB Literary studies: general
Abstract

This head volume of the ´Narrating Futures` series defines and identifies Future Narratives. It parses their characteristic features and aims at an abstract classification of the whole corpus, irrespective of its concrete manifestations across the media. Drawing on different theorems and approaches, it offers a unified theory and a poetics of Future Narratives. Locating the media-historical moment of their emergence, this volume paves the way for the following volumes, which deal with how Future Narratives are refracted through different media.

Published
2013
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8. Catheter ablation of short-coupled variant of torsade de pointes.

Author

Steinfurt, Johannes, Nazer, Babak, Aguilar, Martin, Moss, Joshua, Higuchi, Satoshi, Zarse, Markus, Trolese, Luca, Gressler, Alexander, Faber, Thomas S, Odening, Katja E, Zehender, Manfred, Bode, Christoph, Scheinman, Melvin M, Tedrow, Usha B, and Bogossian, Harilaos

Subjects
Humans, Ventricular Premature Complexes, Torsades de Pointes, Ventricular Fibrillation, DNA-Binding Proteins, Electrocardiography, Catheter Ablation, Retrospective Studies, 3D-mapping, Moderator band, Purkinje, Short-coupled variant of torsade de pointes, Heart Disease, Cardiovascular, Clinical Research, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
Abstract

BackgroundThe short-coupled variant of torsade de pointes (sc-TdP) is a malignant arrhythmia that frequently presents with ventricular fibrillation (VF) electrical storm. Verapamil is considered the first-line therapy of sc-TdP while catheter ablation is not widely adopted. The aim of this study was to determine the origin of sc-TdP and to assess the outcome of catheter ablation using 3D-mapping.Methods and resultsWe retrospectively analyzed five patients with sc-TdP who underwent 3D-mapping and ablation of sc-TdP at five different institutions. Four patients initially presented with sudden cardiac arrest, one patient experienced recurrent syncope as the first manifestation. All patients demonstrated a monomorphic premature ventricular contraction (PVC) with late transition left bundle branch block pattern, superior axis, and a coupling interval of less than 300 ms. triggering recurrent TdP and VF. In four patients, the culprit PVC was mapped to the free wall insertion of the moderator band (MB) with a preceding Purkinje potential in two patients. Catheter ablation using 3D-mapping and intracardiac echocardiography eliminated sc-TdP in all patients, with no recurrence at mean 2.7 years (range 6 months to 8 years) of follow-up.Conclusion3D-mapping and intracardiac echocardiography demonstrate that sc-TdP predominantly originates from the MB free wall insertion and its Purkinje network. Catheter ablation of the culprit PVC at the MB free wall junction leads to excellent short- and long-term results and should be considered as first-line therapy in recurrent sc-TdP or electrical storm.

Published
2022

18. Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study

Author

Supady, Alexander, DellaVolpe, Jeff, Taccone, Fabio Silvio, Scharpf, Dominik, Ulmer, Matthias, Lepper, Philipp M, Halbe, Maximilian, Ziegeler, Stephan, Vogt, Alexander, Ramanan, Raj, Boldt, David, Stecher, Stephanie-Susanne, Montisci, Andrea, Spangenberg, Tobias, Marggraf, Olivier, Kunavarapu, Chandra, Peluso, Lorenzo, Muenz, Sebastian, Buerle, Monica, Nagaraj, Naveen G, Nuding, Sebastian, Toma, Catalin, Gudzenko, Vadim, Stemmler, Hans Joachim, Pappalardo, Federico, Trummer, Georg, Benk, Christoph, Michels, Guido, Duerschmied, Daniel, von zur Muehlen, Constantin, Bode, Christoph, Kaier, Klaus, Brodie, Daniel, Wengenmayer, Tobias, and Staudacher, Dawid L

Subjects
Chemical Engineering, Engineering, Environmental Engineering, Patient Safety, Clinical Research, Rare Diseases, Prevention, Good Health and Well Being, acute respiratory distress syndrome, extracorporeal membrane oxygenation, COVID-19, SARS-CoV-2, Civil Engineering, Chemical engineering, Environmental engineering
Abstract

The role of veno-venous extracorporeal membrane oxygenation therapy (V-V ECMO) in severe COVID-19 acute respiratory distress syndrome (ARDS) is still under debate and conclusive data from large cohorts are scarce. Furthermore, criteria for the selection of patients that benefit most from this highly invasive and resource-demanding therapy are yet to be defined. In this study, we assess survival in an international multicenter cohort of COVID-19 patients treated with V-V ECMO and evaluate the performance of several clinical scores to predict 30-day survival. This is an investigator-initiated retrospective non-interventional international multicenter registry study (NCT04405973, first registered 28 May 2020). In 127 patients treated with V-V ECMO at 15 centers in Germany, Switzerland, Italy, Belgium, and the United States, we calculated the Sequential Organ Failure Assessment (SOFA) Score, Simplified Acute Physiology Score II (SAPS II), Acute Physiology And Chronic Health Evaluation II (APACHE II) Score, Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) Score, Predicting Death for Severe ARDS on V‑V ECMO (PRESERVE) Score, and 30-day survival. In our study cohort which enrolled 127 patients, overall 30-day survival was 54%. Median SOFA, SAPS II, APACHE II, RESP, and PRESERVE were 9, 36, 17, 1, and 4, respectively. The prognostic accuracy for all these scores (area under the receiver operating characteristic-AUROC) ranged between 0.548 and 0.605. The use of scores for the prediction of mortality cannot be recommended for treatment decisions in severe COVID-19 ARDS undergoing V-V ECMO; nevertheless, scoring results below or above a specific cut-off value may be considered as an additional tool in the evaluation of prognosis. Survival rates in this cohort of COVID-19 patients treated with V‑V ECMO were slightly lower than those reported in non-COVID-19 ARDS patients treated with V-V ECMO.

Published
2021

25. Future of Procurement

Author

Bode, Christoph, primary, Burkhart, Davide, additional, Schültken, Ruth, additional, and Vollmer, Marcell, additional

Published
2022
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27. Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 disease

Author

Gauchel, Nadine, Rieder, Marina, Krauel, Krystin, Goller, Isabella, Jeserich, Maren, Salzer, Ulrich, Venhoff, Ana Cecilia, Baldus, Niklas, Pollmeier, Luisa, Wirth, Luisa, Kern, Winfried, Rieg, Siegbert, Busch, Hans-Jörg, Hofmann, Maike, Bode, Christoph, Duerschmied, Daniel, Lother, Achim, and Heger, Lukas A.

Published
2022
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29. Apolipoprotein A-I infusions and cardiovascular outcomes in acute myocardial infarction according to baseline LDL-cholesterol levels: the AEGIS-II trial.

Author

Gibson, C Michael, Duffy, Danielle, Bahit, Maria Cecilia, Chi, Gerald, White, Harvey, Korjian, Serge, Alexander, John H, Lincoff, A Michael, Heise, Mark, Kingwell, Bronwyn A, Nicolau, Jose C, Lopes, Renato D, Cornel, Jan H, Lewis, Basil S, Vinereanu, Dragos, Goodman, Shaun G, Bode, Christoph, Steg, Ph Gabriel, Libby, Peter, and Sacks, Frank M

Subjects
LDL cholesterol, MYOCARDIAL infarction, APOLIPOPROTEIN A, CORONARY artery disease, STATINS (Cardiovascular agents), DRUG-eluting stents
Abstract

Background and Aims In the AEGIS-II trial (NCT03473223), CSL112, a human apolipoprotein A1 derived from plasma that increases cholesterol efflux capacity, did not significantly reduce the risk of the primary endpoint through 90 days vs. placebo after acute myocardial infarction (MI). Nevertheless, given the well-established relationship between higher low-density lipoprotein cholesterol (LDL-C) and plaque burden, as well as greater risk reductions seen with PCSK9 inhibitors in patients with baseline LDL-C ≥ 100 mg/dL on statin therapy, the efficacy of CSL112 may be influenced by baseline LDL-C. Methods Overall, 18 219 patients with acute MI, multivessel coronary artery disease, and additional risk factors were randomized to either four weekly infusions of 6 g CSL112 or placebo. This exploratory post-hoc analysis evaluated cardiovascular outcomes by baseline LDL-C in patients prescribed guideline-directed statin therapy at the time of randomization (n = 15 731). Results As baseline LDL-C increased, the risk of the primary endpoint at 90 days lowered in those treated with CSL112 compared with placebo. In patients with LDL-C ≥ 100 mg/dL at randomization, there was a significant risk reduction of cardiovascular death, MI, or stroke in the CSL112 vs. placebo group at 90, 180, and 365 days [hazard ratio.69 (.53–.90),.71 (.57–.88), and.78 (.65–.93)]. In contrast, there was no difference between treatment groups among those with LDL-C < 100 mg/dL at baseline. Conclusions In this population, treatment with CSL112 compared to placebo was associated with a significantly lower risk of recurrent cardiovascular events among patients with a baseline LDL-C ≥ 100 mg/dL. Further studies need to confirm that CSL112 efficacy is influenced by baseline LDL-C. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Pre-medication with oral anticoagulants is associated with better outcomes in a large multinational COVID-19 cohort with cardiovascular comorbidities

Author

Rieder, Marina, Gauchel, Nadine, Kaier, Klaus, Jakob, Carolin, Borgmann, Stefan, Classen, Annika Y., Schneider, Jochen, Eberwein, Lukas, Lablans, Martin, Rüthrich, Maria, Dolff, Sebastian, Wille, Kai, Haselberger, Martina, Heuzeroth, Hanno, Bode, Christoph, von zur Mühlen, Constantin, Rieg, Siegbert, and Duerschmied, Daniel

Published
2022
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36. P2X4 deficiency reduces atherosclerosis and plaque inflammation in mice

Author

Peikert, Alexander, König, Sebastian, Suchanek, Dymphie, Rofa, Karlos, Schäfer, Ibrahim, Dimanski, Daniel, Karnbrock, Lorenz, Bulatova, Kseniya, Engelmann, Juliane, Hoppe, Natalie, Wadle, Carolin, Heidt, Timo, Albrecht, Philipp, von Garlen, Sunaina, Härdtner, Carmen, Hilgendorf, Ingo, Wolf, Dennis, von zur Mühlen, Constantin, Bode, Christoph, Zirlik, Andreas, Duerschmied, Daniel, Merz, Julian, and Stachon, Peter

Published
2022
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38. Elevated platelet–leukocyte complexes are associated with, but dispensable for myocardial ischemia–reperfusion injury

Author

Starz, Christopher, Härdtner, Carmen, Mauler, Maximilian, Dufner, Bianca, Hoppe, Natalie, Krebs, Katja, Ehlert, Carolin Anna, Merz, Julian, Heidt, Timo, Stachon, Peter, Wolf, Dennis, Bode, Christoph, von zur Muehlen, Constantin, Rottbauer, Wolfgang, Gawaz, Meinrad, Duerschmied, Daniel, Leuschner, Florian, Borst, Oliver, Westermann, Dirk, and Hilgendorf, Ingo

Published
2022
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39. P2Y12-dependent activation of hematopoietic stem and progenitor cells promotes emergency hematopoiesis after myocardial infarction

Author

Seung, Hana, Wrobel, Jan, Wadle, Carolin, Bühler, Timon, Chiang, Diana, Rettkowski, Jasmin, Cabezas-Wallscheid, Nina, Hechler, Béatrice, Stachon, Peter, Maier, Alexander, Weber, Christian, Wolf, Dennis, Duerschmied, Daniel, Idzko, Marco, Bode, Christoph, von zur Mühlen, Constantin, Hilgendorf, Ingo, and Heidt, Timo

Published
2022
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45. Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial

Author

Supady, Alexander, Weber, Enya, Rieder, Marina, Lother, Achim, Niklaus, Tim, Zahn, Timm, Frech, Franziska, Müller, Sissi, Kuhl, Moritz, Benk, Christoph, Maier, Sven, Trummer, Georg, Flügler, Annabelle, Krüger, Kirsten, Sekandarzad, Asieb, Stachon, Peter, Zotzmann, Viviane, Bode, Christoph, Biever, Paul M, Staudacher, Dawid, Wengenmayer, Tobias, Graf, Erika, and Duerschmied, Daniel

Published
2021
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49. Prevalence, clinical determinants and prognostic implications of coronary procedural complications of percutaneous coronary intervention in non-ST-segment elevation myocardial infarction: Insights from the contemporary multinational TAO trial

Author

Abtan, Jeremie, Wiviott, Stephen D., Sorbets, Emmanuel, Popovic, Batric, Elbez, Yedid, Mehta, Shamir R., Sabatine, Marc S., Bode, Christoph, Pollack, Charles V., Cohen, Marc, Moccetti, Tiziano, Laanmets, Peep, Faxon, David, Okreglicki, Andrzej, Ducrocq, Gregory, and Steg, Ph. Gabriel

Published
2021
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