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7. Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual

Author

Kocher, Katharina, primary, Moosmann, Carolin, additional, Drost, Felix, additional, Schülein, Christine, additional, Irrgang, Pascal, additional, Steininger, Philipp, additional, Zhong, Jahn, additional, Träger, Johannes, additional, Spriewald, Bernd, additional, Bock, Christoph, additional, Busch, Dirk H, additional, Bogdan, Christian, additional, Schubert, Benjamin, additional, Winkler, Thomas H, additional, Tenbusch, Matthias, additional, Schuster, Ev-Marie, additional, and Schober, Kilian, additional

Published
2024
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8. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Author

Cossarizza, Andrea, Chang, Hyun-Dong, Radbruch, Andreas, Acs, Andreas, Adam, Dieter, Adam-Klages, Sabine, Agace, William W, Aghaeepour, Nima, Akdis, Mübeccel, Allez, Matthieu, Almeida, Larissa Nogueira, Alvisi, Giorgia, Anderson, Graham, Andrä, Immanuel, Annunziato, Francesco, Anselmo, Achille, Bacher, Petra, Baldari, Cosima T, Bari, Sudipto, Barnaba, Vincenzo, Barros-Martins, Joana, Battistini, Luca, Bauer, Wolfgang, Baumgart, Sabine, Baumgarth, Nicole, Baumjohann, Dirk, Baying, Bianka, Bebawy, Mary, Becher, Burkhard, Beisker, Wolfgang, Benes, Vladimir, Beyaert, Rudi, Blanco, Alfonso, Boardman, Dominic A, Bogdan, Christian, Borger, Jessica G, Borsellino, Giovanna, Boulais, Philip E, Bradford, Jolene A, Brenner, Dirk, Brinkman, Ryan R, Brooks, Anna ES, Busch, Dirk H, Büscher, Martin, Bushnell, Timothy P, Calzetti, Federica, Cameron, Garth, Cammarata, Ilenia, Cao, Xuetao, Cardell, Susanna L, Casola, Stefano, Cassatella, Marco A, Cavani, Andrea, Celada, Antonio, Chatenoud, Lucienne, Chattopadhyay, Pratip K, Chow, Sue, Christakou, Eleni, Čičin-Šain, Luka, Clerici, Mario, Colombo, Federico S, Cook, Laura, Cooke, Anne, Cooper, Andrea M, Corbett, Alexandra J, Cosma, Antonio, Cosmi, Lorenzo, Coulie, Pierre G, Cumano, Ana, Cvetkovic, Ljiljana, Dang, Van Duc, Dang-Heine, Chantip, Davey, Martin S, Davies, Derek, De Biasi, Sara, Del Zotto, Genny, Dela Cruz, Gelo Victoriano, Delacher, Michael, Della Bella, Silvia, Dellabona, Paolo, Deniz, Günnur, Dessing, Mark, Di Santo, James P, Diefenbach, Andreas, Dieli, Francesco, Dolf, Andreas, Dörner, Thomas, Dress, Regine J, Dudziak, Diana, Dustin, Michael, Dutertre, Charles-Antoine, Ebner, Friederike, Eckle, Sidonia BG, Edinger, Matthias, Eede, Pascale, Ehrhardt, Götz RA, Eich, Marcus, Engel, Pablo, Engelhardt, Britta, and Erdei, Anna

Subjects
1.1 Normal biological development and functioning, Underpinning research, Inflammatory and immune system, Allergy and Immunology, Cell Separation, Consensus, Flow Cytometry, Humans, Phenotype, Immunology
Abstract

These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.

Published
2019

10. The Aspergillus galactomannan Ag VIRCLIA® Monotest and the sõna Aspergillus galactomannan lateral flow assay show comparable performance for the diagnosis of invasive aspergillosis.

Author

Küpper, Corinna, Erb, Timothy Moritz, Träger, Johannes, Meintker, Lisa, Valenza, Giuseppe, Bogdan, Christian, and Held, Jürgen

Subjects
MYCOSES, RECEIVER operating characteristic curves, ASPERGILLOSIS, BRONCHOALVEOLAR lavage, ASPERGILLUS
Abstract

Background: Rapid galactomannan tests, such as the sõna Aspergillus GM Lateral Flow Assay (GM‐LFA) and the Aspergillus Galactomannan Ag VIRCLIA® Monotest (GM‐Monotest), which are suitable for the analysis of single samples, have the potential to accelerate diagnosis of invasive aspergillosis (IA). Objectives: To compare the performance of the GM‐Monotest and the GM‐LFA for the diagnosis of IA. Patients/Methods: Two patient cohorts were analysed: adults who had received an allogeneic haematopoietic stem‐cell transplant (alloHSCT‐cohort) and patients with proven/probable IA from a 5‐year period (cross‐sectional IA‐cohort). In the alloHSCT‐cohort, weekly serum samples were tested, whereas in the cross‐sectional IA‐cohort sera and bronchoalveolar lavage fluids were analysed. The diagnostic performance was calculated using two definitions for positivity: (1) a single positive GM result and (2) at least two positive GM results from consecutive samples. IA classification followed EORTC/MSG 2019. Results: The alloHSCT‐cohort included 101 patients. Four had proven/probable IA, 26 possible IA and 71 no IA. The specificity for one positive serum and two consecutively positive sera was 88.7% and 100% (GM‐Monotest) and 85.9% and 98.6% (GM‐LFA). Comparison of ROC curves in the alloHSCT‐cohort showed no significant difference. The cross‐sectional IA‐cohort included 59 patients with proven/probable IA. The sensitivity for one positive sample and two consecutively positive samples was 83.1% and 55.1% (GM‐Monotest) and 86.4% and 71.4% (GM‐LFA). Conclusions: Both assays showed comparable diagnostic performance with a higher sensitivity for the GM‐LFA if two consecutive positive samples were required for positivity. However, due to poor reproducibility, positive GM‐LFA results should always be confirmed. [ABSTRACT FROM AUTHOR]

Published
2024
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16. The DAMIC-M experiment: Status and first results

Author

Isaac J. Arnquist, Nicolas Avalos, Philippe Bailly, David Baxter, Xavier Bertou, Mircea Bogdan, Christian Bourgeois, J. Brandt, Arnaud Cadiou, Nuria Castelló-Mor, Alvaro E. Chavarria, Marcel Conde, Nicholas J. Corso, J. C. Gutiérrez, Julian Cuevas-Zepeda, Ali Dastgheibi-Fard, Claudia De Dominicis, Olivier Deligny, R. Desani, Marc Dhellot, Jean-Jacques Dormard, Jordi Duarte-Campderros, E. Estrada, D. Florin, N. Gadola, R. Gaïor, J. González Sánchez, Todd W. Hossbach, Michael Huehn, Latifa Khalil, Ben Kilminster, Agustin Lantero-Barreda, Ian Lawson, Hervé Lebbolo, Steven Lee, Pascal Leray, Antoine Letessier-Selvon, Pia Loaiza, Amparo Lopez-Virto, David Martin, Ariel Matalon, Kellie McGuire, T. Milleto, Pitam Mitra, David M. Martin, S. Munagavalasa, Danielle Norcini, Cory T. Overman, Giorgos Papadopoulos, S. Paul, David Peterson, Alexander Piers, Olivier Pochon, Paolo Privitera, Karthik Ramanathan, Denis Reynet, Peter Robmann, Ryan Roehnelt, Mariangela Settimo, Radomir Smida, Ben Stillwell, Ryan Thomas, Michelangelo Traina, Philippe Vallerand, Tim Van Wechel, Ivan Vila, Rocio V. Cortabitarte, Achim Vollhardt, Guillaume Warot, D. Wolf, Rachana Yajur, J-P. Zopounidis

Subjects
Physics, QC1-999
Abstract

The DAMIC-M (DArk Matter In CCDs at Modane) experiment employs thick, fully depleted silicon charged-coupled devices (CCDs) to search for dark matter particles with a target exposure of 1 kg-year. A novel skipper readout implemented in the CCDs provides single electron resolution through multiple non-destructive measurements of the individual pixel charge, pushing the detection threshold to the eV-scale. DAMIC-M will advance by several orders of magnitude the exploration of the dark matter particle hypothesis, in particular of candidates pertaining to the so-called "hidden sector." A prototype, the Low Background Chamber (LBC), with 20g of low background Skipper CCDs, has been recently installed at Laboratoire Souterrain de Modane and is currently taking data. We will report the status of the DAMIC-M experiment and first results obtained with LBC commissioning data.

Published
2023
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19. S2k-Leitlinie Gastrointestinale Infektionen der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS).

Author

Manthey, Carolin F., Epple, Hans-Jörg, Keller, Klaus-Michael, Lübbert, Christoph, Posovszky, Carsten, Ramharter, Michael, Reuken, Philipp, Suerbaum, Sebastian, Vehreschild, Maria, Weinke, Thomas, Addo, Marylyn M., Stallmach, Andreas, Lohse, Ansgar W., Adam, Rüdiger, Bogdan, Christian, Flieger, Antje, Frost, Fabian, Fruth, Angelika, Hagel, Stefan, and Katzer, Katrin

Published
2024
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20. Arginase impedes the resolution of colitis by altering the microbiome and metabolome

Author

Baier, Julia, Gansbauer, Maximilian, Giessler, Claudia, Arnold, Harald, Muske, Mercedes, Schleicher, Ulrike, Lukassen, Soren, Ekici, Arif, Rauh, Manfred, Daniel, Christoph, Hartmann, Arndt, Schmid, Benjamin, Tripal, Philipp, Dettmer, Katja, Oefner, Peter J., Atreya, Raja, Wirtz, Stefan, Bogdan, Christian, and Mattner, Jochen

Subjects
Hydrolases -- Health aspects, Metabolites -- Health aspects, Microbiota (Symbiotic organisms) -- Health aspects, Arginine -- Chemical properties -- Health aspects, Colitis -- Care and treatment -- Models, Health care industry
Abstract

Arginase 1 (Arg1), which converts L-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects. However, the function of Arg1 in inflammatory bowel disease (IBD) remains poorly characterized. Here, we found that Arg1 expression correlated with the degree of inflammation in intestinal tissues from IBD patients. In mice, Arg1 was upregulated in an IL-4/ IL-13 and intestinal microbiota-dependent manner. Tie2-Cre [Arg1.sup.fl/fl] mice lacking Arg7 in hematopoietic and endothelial cells recovered faster from colitis than Arg7-expressing([Arg1.sup.fl/fl]) littermates. This correlated with decreased vessel density, compositional changes in intestinal microbiota, diminished infiltration by myeloid cells, and an accumulation of intraluminal polyamines that promote epithelial healing. The proresolving effect of Arg1 deletion was reduced by an L-arginine- free diet, but rescued by simultaneous deletion of other L-arginine-metabolizing enzymes, such as Arg2 or Alos2, demonstrating that protection from colitis requires L-arginine. Fecal microbiota transfers from Tie2-Cre [Arg1.sup.fl/fl] mice into WT recipients ameliorated intestinal inflammation, while transfers from WT littermates intoArg7-deficient mice prevented an advanced recovery from colitis. Thus, an increased availability of L-arginine as well as altered intestinal microbiota and metabolic products accounts for the accelerated resolution from colitis in the absence of Arg1. Consequently, L-arginine metabolism may serve as a target for clinical intervention in IBD patients., Introduction Ulcerative colitis (UC) and Crohn's disease (CD) are characterized by an immune-mediated inflammation of the gastrointestinal (GI) tract. Both inflammatory bowel diseases (IBDs) are thought to result from dysregulated [...]

Published
2020
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22. Impfen bei Immundefizienz: Anwendungshinweise zu den von der Ständigen Impfkommission empfohlenen Impfungen. (III) Impfen bei hämatologischen und onkologischen Erkrankungen (antineoplastische Therapie, Stammzelltransplantation), Organtransplantation und Asplenie

Author

Laws, Hans-Jürgen, Baumann, Ulrich, Bogdan, Christian, Burchard, Gerd, Christopeit, Maximilian, Hecht, Jane, Heininger, Ulrich, Hilgendorf, Inken, Kern, Winfried, Kling, Kerstin, Kobbe, Guido, Külper, Wiebe, Lehrnbecher, Thomas, Meisel, Roland, Simon, Arne, Ullmann, Andrew, de Wit, Maike, and Zepp, Fred

Published
2020
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23. β-(1→3)-D-glucan- and mannan-guided early termination of antifungal therapy in ICU patients: a randomized controlled study

Author

Erb, Timothy, primary, Mihai, Sidonia, additional, Strauß, Richard, additional, Herbst, Larissa, additional, Castellanos, Ixchel, additional, Diesch, Katharina, additional, Cipa, Franziska, additional, Bihlmaier, Karl, additional, Lang, Anne-Katharina, additional, Ganslmayer, Marion, additional, Willam, Carsten, additional, Bremer, Frank, additional, Fürst, Julia, additional, Beyer, Christian, additional, Bogdan, Christian, additional, Rath, Anca, additional, and Held, Jürgen, additional

Published
2023
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26. Erratum zu: Impfen bei Immundefizienz: Anwendungshinweise zu den von der Ständigen Impfkommission empfohlenen Impfungen. (III) Impfen bei hämatologischen und onkologischen Erkrankungen (antineoplastische Therapie, Stammzelltransplantation), Organtransplantation und Asplenie

Author

Laws, Hans-Jürgen, Baumann, Ulrich, Bogdan, Christian, Burchard, Gerd, Christopeit, Maximilian, Hecht, Jane, Heininger, Ulrich, Hilgendorf, Inken, Kern, Winfried, Kling, Kerstin, Kobbe, Guido, Külper, Wiebe, Lehrnbecher, Thomas, Meisel, Roland, Simon, Arne, Ullmann, Andrew, de Wit, Maike, and Zepp, Fred

Published
2020
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27. Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis

Author

Hannemann, Nicole, Cao, Shan, Eriksson, Daniel, Schnelzer, Anne, Jordan, Jutta, Schleicher, Martin EberhardUlrike, Rech, Jurgen, Ramming, Andreas, Uebe, Steffen, Ekici, Arif, Canete, Juan D., Chen, Xiaoxiang, Bauerle, Tobias, Vera, Julio, Bogdan, Christian, and Bozec, Georg Schetand Aline

Subjects
Interleukins -- Analysis, Macrophages -- Analysis, Rheumatoid factor -- Analysis, Inflammation -- Analysis, Genes -- Analysis, Arthritis -- Analysis, DNA binding proteins -- Analysis, Arginine, Antigens, Luciferase, Journalists, Wounds, Health care industry
Abstract

The polarization of macrophages is regulated by transcription factors, such as NF-[kappa]B and activator protein 1 (AP-1). In this manuscript, we delineated the role of the transcription factor Fos-related antigen 1 (Fra-1) during macrophage activation and development of arthritis. Network level interaction analysis of microarray data derived from Fra-1- or Fra-2-deficient macrophages revealed a central role of Fra-1, but not of Fra-2, in orchestrating the expression of genes related to wound response, Toll-like receptor activation, and interleukin signaling. ChIP sequencing and standard ChIP analyses of macrophages identified arginase 1 (Arg1) as a target of Fra-1. Luciferase reporter assays revealed that Fra-1 downregulated Arg1 expression by direct binding to the promoter region. Using macrophage-specific Fra-1- or Fra-2-deficient mice, we observed enhanced expression and activity of Arg1 and a reduction of arthritis in the absence of Fra-1, but not of Fra-2. This phenotype was reversed by treatment with the arginase inhibitor [N.sup.[omega]]-hydroxy-nor-l-arginine, while L-arginine supplementation increased arginase activity and alleviated arthritis, supporting the notion that reduced arthritis in macrophage-specific Fra-1-deficient mice resulted from enhanced Arg1 expression and activity. Moreover, patients with active rheumatoid arthritis (RA) showed increased Fra-1 expression in the peripheral blood and elevated Fra-1 protein in synovial macrophages compared with RA patients in remission. In addition, the Fra-1/ARG1 ratio in synovial macrophages was related to RA disease activity. In conclusion, these data suggest that Fra-1 orchestrates the inflammatory state of macrophages by inhibition of Arg1 expression and thereby impedes the resolution of inflammation., Introduction Macrophages are remarkably diverse in their plasticity, allowing adaptation to a broad range of environmental stimuli. They participate in various processes essential for homeostatic functions and development, but also [...]

Published
2019
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28. Impfen bei Immundefizienz: Anwendungshinweise zu den von der Ständigen Impfkommission empfohlenen Impfungen. (IV) Impfen bei Autoimmunkrankheiten, bei anderen chronisch-entzündlichen Erkrankungen und unter immunmodulatorischer Therapie

Author

Wagner, Norbert, Assmus, Frauke, Arendt, Gabriele, Baum, Erika, Baumann, Ulrich, Bogdan, Christian, Burchard, Gerd, Föll, Dirk, Garbe, Edeltraut, Hecht, Jane, Müller-Ladner, Ulf, Niehues, Tim, Überla, Klaus, Vygen-Bonnet, Sabine, Weinke, Thomas, Wiese-Posselt, Miriam, Wojcinski, Michael, and Zepp, Fred

Published
2019
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30. Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass

Author

Lai, Chaobo, Heinemann, Jennifer, Schleicher, Ulrike, Schett, Georg, Bogdan, Christian, Bozec, Aline, and Soulat, Didier

Subjects
Endocrinology, Diabetes and Metabolism, Orthopedics and Sports Medicine
Abstract

Vector-borne infections of humans with the protozoan parasite Leishmania (L.) infantum can cause a systemic and potentially lethal disease termed visceral leishmaniasis. In the corresponding mouse model, an intravenous infection with L. infantum leads to the persistence of parasites in various organs, including bone marrow (BM). Considering the anatomical proximity between the BM and the cortical bone, we investigated whether a chronic infection with L. infantum affected bone homeostasis. Unexpectedly, chronic infection with L. infantum caused an increase in bone mass in mice. In vivo, an increased number of osteoblasts and osteocytes and a decreased maturation of osteoclasts characterized the phenotype. Confocal laser scanning fluorescence microscopy confirmed the infection of BM macrophages but also revealed the presence of parasites in osteoclasts. In vitro, mature osteoclasts took up L. infantum parasites. However, infection of osteoclast progenitors abolished their differentiation and function. In addition, secretory products of infected BM-derived macrophages inhibited the maturation of osteoclasts. Both in vitro and in vivo, infected macrophages and osteoclasts showed an enhanced expression of the anti-osteoclastogenic chemokine CCL5 (RANTES). Neutralization of CCL5 prevented the inhibition of osteoclast generation seen in the presence of culture supernatants from L. infantum-infected macrophages. Altogether, our study shows that chronic infection with Leishmania increases bone mass by inducing bone formation and impairing osteoclast differentiation and function. © 2022 American Society for Bone and Mineral Research (ASBMR).

Published
2022

36. Wissenschaftliche Begründung der STIKO zur Implementierung der COVID-19-Impfung in die allgemeinen Empfehlungen der STIKO 2023

Author

Koch, Judith, Piechotta, Vanessa, Berner, Reinhard, Bogdan, Christian, Burchard, Gerd, Heininger, Ulrich, Hummers, Eva, von Kries, Rüdiger, Ledig, Thomas, Littmann, Martina, Meerpohl, Joerg, Mertens, Thomas, Röbl-Mathieu, Marianne, van der Sande, Marianne, Sander, Leif Erik, Terhardt, Martin, Überla, Klaus, Vygen-Bonnet, Sabine, Wichmann, Ole, Wicker, Sabine, Wiedermann-Schmidt, Ursula, Widders, Gudrun, and Zepp, Fred

Subjects
SARS-CoV-2, Basisimmunität, STIKO-Impfempfehlung, COVID-19, Schutzimpfung, ddc:610, 610 Medizin und Gesundheit
Abstract

Die COVID-19-Impfempfehlungen der STIKO ha¬ben seit Beginn der Impfkampagne im Winter 2020/2021 das vordringliche Ziel, schwere Verläufe und Langzeit¬folgen von COVID-19 zu verhindern sowie Beschäf¬tigte in der medizinischen und pflegenden Versor¬gung vor SARS-CoV-2-Infektionen zu schützen. Die STIKO hat ihre COVID-19-Impfempfehlung seit der Erstpublikation im Dezember 2020 unter der Berücksichtigung neuer Daten und wei¬teren Impfstoffzulassungen fortlaufend angepasst. Beim Übergang von der pandemischen in die ende¬mische Phase des Infektionsgeschehens hat sich die STIKO mit der Überführung der bisherigen Emp¬fehlungen in eine längerfristige COVID-19-Impfempfehlung befasst. Im Epidemiologischen Bulletin 21/2023 wird die dazugehörige wissenschaftliche Begründung der aktualisierten Empfehlung und der Integration in den Impfkalender veröffentlicht. Die neue Empfehlung ersetzt die 25. Aktualisierung der COVID-19-Impfempfehlung von Februar 2023, die nicht mehr länger gültig ist.

Published
2023

37. LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

Author

Brand, Almut, Singer, Katrin, Koehl, Gudrun E., Kolitzus, Marlene, Schoenhammer, Gabriele, Thiel, Annette, Matos, Carina, Bruss, Christina, Klobuch, Sebastian, Peter, Katrin, Kastenberger, Michael, Bogdan, Christian, Schleicher, Ulrike, Mackensen, Andreas, Ullrich, Evelyn, Fichtner-Feigl, Stefan, Kesselring, Rebecca, Mack, Matthias, Ritter, Uwe, Schmid, Maximilian, Blank, Christian, Dettmer, Katja, Oefner, Peter J., Hoffmann, Petra, Walenta, Stefan, Geissler, Edward K., Pouyssegur, Jacques, Villunger, Andreas, Steven, André, Seliger, Barbara, Schreml, Stephan, Haferkamp, Sebastian, Kohl, Elisabeth, Karrer, Sigrid, Berneburg, Mark, Herr, Wolfgang, Mueller-Klieser, Wolfgang, Renner, Kathrin, and Kreutz, Marina

Published
2016
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39. BlocklyVR : Exploring Block-based Programming in Virtual Reality

Author

Hedlund, Martin, Jonsson, Adam, Bogdan, Christian, Meixner, Gerrit, Ekblom Bak, Elin, Matviienko, Andrii, Hedlund, Martin, Jonsson, Adam, Bogdan, Christian, Meixner, Gerrit, Ekblom Bak, Elin, and Matviienko, Andrii

Abstract

As programming is typically a static activity in front of a screen, we perform an initial exploration around the capabilities of block-based programming in the immersive space using Virtual Reality (VR) to make an early charting on how programming could involve moving the programmer's body. We created a block-based programming interface in a VR space called BlocklyVR based on the existing Blockly programming environment. To investigate programmer performance and experience in BlocklyVR, we conducted a controlled lab experiment (N = 20) with eight programming tasks that covered mathematical operations, if-statements, and function creation. Our initial exploration contributes by classifying movement types made by BlocklyVR programmers and reflecting on how these movements are related to the programming tasks. Additionally, our data suggests that participant performance in BlocklyVR was not affected compared to the 2D Blockly, even if participants were physically moving in VR space. We also found that the virtual reality sickness was marginal. Lastly, we identified four types of interaction that can potentially be employed by VR designers and developers aiming to convert a static task, like programming at a desk, into a "mobile"immersive experience. © 2023 Owner/Author.

Published
2023
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40. Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever

Author

Kohl, Lisa, Siddique, Md Nur A. Alam, Bodendorfer, Barbara, Berger, Raffaela, Preikschat, Annica, Daniel, Christoph, Oelke, Martha, Liebler-Tenorio, Elisabeth, Schulze-Luehrmann, Jan, Mauermeir, Michael, Yang, Kai-Ting, Hayek, Inaya, Szperlinski, Manuela, Andrack, Jennifer, Schleicher, Ulrike, Bozec, Aline, Kroenke, Gerhard, Murray, Peter J., Wirtz, Stefan, Yamamoto, Masahiro, Schatz, Valentin, Jantsch, Jonathan, Oefner, Peter, Degrandi, Daniel, Pfeffer, Klaus, Mertens-Scholz, Katja, Rauber, Simon, Bogdan, Christian, Dettmer, Katja, Luehrmann, Anja, Lang, Roland, Kohl, Lisa, Siddique, Md Nur A. Alam, Bodendorfer, Barbara, Berger, Raffaela, Preikschat, Annica, Daniel, Christoph, Oelke, Martha, Liebler-Tenorio, Elisabeth, Schulze-Luehrmann, Jan, Mauermeir, Michael, Yang, Kai-Ting, Hayek, Inaya, Szperlinski, Manuela, Andrack, Jennifer, Schleicher, Ulrike, Bozec, Aline, Kroenke, Gerhard, Murray, Peter J., Wirtz, Stefan, Yamamoto, Masahiro, Schatz, Valentin, Jantsch, Jonathan, Oefner, Peter, Degrandi, Daniel, Pfeffer, Klaus, Mertens-Scholz, Katja, Rauber, Simon, Bogdan, Christian, Dettmer, Katja, Luehrmann, Anja, and Lang, Roland

Abstract

Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis-aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fever. Infection of mice with C. burnetii induced expression of several anti-microbial candidate genes, including Acod1. In macrophages, Acod1 was essential for restricting C. burnetii replication, while other antimicrobial pathways were dispensable. Intratracheal or intraperitoneal infection of Acod1(-/-) mice caused increased C. burnetii burden, weight loss and stronger inflammatory gene expression. Exogenously added itaconate restored pathogen control in Acod1(-/-) mouse macrophages and blocked replication in human macrophages. In axenic cultures, itaconate directly inhibited growth of C. burnetii. Finally, treatment of infected Acod1(-/-) mice with itaconate efficiently reduced the tissue pathogen load. Thus, ACOD1-derived itaconate is a key factor in the macrophage-mediated defense against C. burnetii and may be exploited for novel therapeutic approaches in chronic Q fever.

Published
2023

41. Empfehlungen der Ständigen Impfkommission (STIKO) und der Deutschen Gesellschaft für Tropenmedizin, Reisemedizin und Globale Gesundheit e.V. (DTG) zu Reiseimpfungen

Author

Kling, Kerstin, Külper-Schiek, Wiebe, Rothe, Camilla, Alberer, Martin, Boecken, Gerhard, Bogdan, Christian, Feldt, Torsten, Köhler, Carsten, Ledig, Thomas, Löscher, Thomas, Meerpohl, Jörg, Mertens, Thomas, Ramharter, Michael, Rieke, Burkhard, Röbl-Mathieu, Marianne, Rosenbusch, Deike, Schmidt-Chanasit, Jonas, Wichmann, Ole, Wiedermann, Ursula, Zepp, Fred, and Burchard, Gerd

Subjects
Reiseimpfungen, Schutzimpfungen, STIKO, Impfempfehlung, ddc:610, Prävention, 610 Medizin und Gesundheit
Abstract

Die STIKO empfiehlt Reiseimpfungen zum individuellen Schutz Reisender mit einem Expositionsrisiko gegenüber bestimmten impfpräventablen Erkrankungen und um den Import von Infektionserregern in das bereiste Land oder bei Rückreise nach Deutschland zu verhindern. Die im Epidemiologischen Bulletin 14/2023 veröffentlichten Empfehlungen zu Reiseimpfungen wurden von der STIKO-AG Reiseimpfungen in Zusammenarbeit mit externen Expertinnen und Experten erarbeitet. Neuerungen sind dabei u. a. die aktualisierte Epidemiologie bei Cholera, Hepatitis A, Hepatitis B, Meningokokken und Typhus sowie eine umfassende Literatur-Aktualisierung.

Published
2023

42. Wissenschaftliche Begründung der STIKO zur Entscheidung, den COVID-19-Impfstoff VidPrevtyn Beta zur Auffrischimpfung von Personen ≥ 18 Jahren derzeit nicht zu empfehlen

Author

Piechotta, Vanessa, Koch, Judith, Bogdan, Christian, Burchard, Gerd, Garbe, Edeltraut, Heininger, Ulrich, Hummers, Eva, von Kries, Rüdiger, Ledig, Thomas, Littmann, Martina, Meerpohl, Joerg, Mertens, Thomas, Meyer, Heidi, Röbl-Mathieu, Marianne, van der Sande, Marianne, Sander, Leif Erik, Terhardt, Martin, Überla, Klaus, Wichmann, Ole, Wicker, Sabine, Wiedermann-Schmidt, Ursula, Widders, Gudrun, and Zepp, Fred

Subjects
STIKO-Impfempfehlung, COVID-19, ddc:610, proteinbasierter Impfstoff, Auffrischimpfung, VidPrevtyn Beta, 610 Medizin und Gesundheit
Abstract

Die EU hat am 10.11.2022 den proteinbasierten COVID-19-Impfstoff VidPrevtyn der Firma Sanofi Pasteur für Personen ab 18 Jahren zur Auffrischimpfung nach Grundimmunisierung mit einem mRNA-Impfstoff oder einem adenoviralen Vektorimpfstoff zugelassen. VidPrevtyn Beta ist nach Nuvaxovid (Novavax) der zweite proteinbasierte COVID-19-Impfstoff, der in der EU eine Zulassung erhält. Wie das Epidemiologische Bulletin 8/2023 ausführt, hat die STIKO nach Bewertung der Daten aus den Zulassungsstudien entschieden, die Anwendung von VidPrevtyn Beta für die COVID-19-Auffrischimpfung in Deutschland derzeit nicht zu empfehlen, da die Datenlage äußerst limitiert ist. Da es sich bei VidPrevtyn Beta um einen zugelassenen Impfstoff handelt, kann dieser trotz fehlender STIKO-Empfehlung verwendet werden. Zum Beispiel kann der Einsatz begründet sein, wenn produktspezifische, medizinische Kontraindikationen gegenüber den anderen verfügbaren COVID-19-Impfstoffen bestehen.

Published
2023

43. Wissenschaftliche Begründung der STIKO zur Aktualisierung der Empfehlung zur SARS-CoV-2-Prä-Expositionsprophylaxe mit Tixagevimab/Cilgavimab (Evusheld)

Author

Mikolajewska, Agata, Kling, Kerstin, Piechotta, Vanessa, Koch, Judith, Burchard, Gerd, Garbe, Edeltraut, Heininger, Ulrich, Jensen, Björn-Erik Ole, von Kries, Rüdiger, Ledig, Thomas, Littmann, Martina, Malin, Jakob, Meerpohl, Joerg, Mertens, Thomas, Meyer, Heidi, Röbl-Mathieu, Marianne, van der Sande, Marianne, Sander, Leif Erik, Spinner, Christoph Daniel, Stegemann, Miriam Songa, Terhardt, Martin, Überla, Klaus, Wichmann, Ole, Wicker, Sabine, Wiedermann, Ursula, Widders, Gudrun, Wörmann, Bernhard, Zepp, Fred, and Bogdan, Christian

Subjects
Evusheld, STIKO-Impfempfehlung, nMAK, COVID-19, ddc:610, SARS-CoV-2-PrEP, 610 Medizin und Gesundheit
Abstract

In der im Epidemiologischen Bulletin 8/2023 veröffentlichten 25. Aktualisierung der COVID-19-Impfempfehlung grenzt die STIKO unter Berücksichtigung der dynamischen Datenlage zu den derzeit verbreiteten SARS-CoV-2-Varianten und deren Sublinien, der u. U. ausbleibenden Neutrali-sationskapazität von Evusheld gegen einige neuere Sublinien sowie der verfügbaren und nach wie vor wirksamen Optionen zur antiviralen Frühtherapie ihre Empfehlung zur PrEP mit Evusheld weiter ein. Eine PrEP mit Evusheld sollte nur noch in begründeten Einzelfällen in Betracht gezogen werden.

Published
2023

45. Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination

Author

Irrgang, Pascal, primary, Gerling, Juliane, additional, Kocher, Katharina, additional, Lapuente, Dennis, additional, Steininger, Philipp, additional, Habenicht, Katharina, additional, Wytopil, Monika, additional, Beileke, Stephanie, additional, Schäfer, Simon, additional, Zhong, Jahn, additional, Ssebyatika, George, additional, Krey, Thomas, additional, Falcone, Valeria, additional, Schülein, Christine, additional, Peter, Antonia Sophia, additional, Nganou-Makamdop, Krystelle, additional, Hengel, Hartmut, additional, Held, Jürgen, additional, Bogdan, Christian, additional, Überla, Klaus, additional, Schober, Kilian, additional, Winkler, Thomas H., additional, and Tenbusch, Matthias, additional

Published
2023
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46. Orofacial clefts alter early life oral microbiome maturation towards higher levels of potentially pathogenic species: A prospective observational study

Author

Seidel, Corinna L., primary, Strobel, Karin, additional, Weider, Matthias, additional, Tschaftari, Marco, additional, Unertl, Christoph, additional, Willershausen, Ines, additional, Weber, Manuel, additional, Hoerning, André, additional, Morhart, Patrick, additional, Schneider, Michael, additional, Beckmann, Matthias W., additional, Bogdan, Christian, additional, Gerlach, Roman G., additional, and Gölz, Lina, additional

Published
2023
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49. Macrophages inhibit Coxiella burnetii by the ACOD1 ‐itaconate pathway for containment of Q fever

Author

Kohl, Lisa, primary, Siddique, Md Nur A Alam, additional, Bodendorfer, Barbara, additional, Berger, Raffaela, additional, Preikschat, Annica, additional, Daniel, Christoph, additional, Ölke, Martha, additional, Liebler‐Tenorio, Elisabeth, additional, Schulze‐Luehrmann, Jan, additional, Mauermeir, Michael, additional, Yang, Kai‐Ting, additional, Hayek, Inaya, additional, Szperlinski, Manuela, additional, Andrack, Jennifer, additional, Schleicher, Ulrike, additional, Bozec, Aline, additional, Krönke, Gerhard, additional, Murray, Peter J, additional, Wirtz, Stefan, additional, Yamamoto, Masahiro, additional, Schatz, Valentin, additional, Jantsch, Jonathan, additional, Oefner, Peter, additional, Degrandi, Daniel, additional, Pfeffer, Klaus, additional, Mertens‐Scholz, Katja, additional, Rauber, Simon, additional, Bogdan, Christian, additional, Dettmer, Katja, additional, Lührmann, Anja, additional, and Lang, Roland, additional

Published
2022
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