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2. Decreased smooth muscle cell/extracellular matrix ratio of media of femoral artery in patients with atherosclerosis and hyperhomocysteinemia

Author

Vermeulen, E G, Niessen, H W, Bogels, M, Stehouwer, C D, Rauwerda, J A, van Hinsbergh, V W, Surgery, Pathology, Cardio-thoracic surgery, ACS - Heart failure & arrhythmias, AGEM - Digestive immunity, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, CCA - Target Discovery & Preclinial Therapy Development, AII - Inflammatory diseases, and Physiology

Abstract

The aim of this study was to determine whether the morphology of the muscular femoral artery in patients with atherosclerosis and hyperhomocysteinemia differs from that of atherosclerotic vessels from patients with normal homocysteine levels. Whole-vessel biopsies of the superficial femoral artery were taken from patients with symptomatic atherosclerotic disease with and without hyperhomocysteinemia and from patients without atherosclerosis from traumatic amputations. The morphology of these specimens was studied qualitatively by light and electron microscopy and quantitatively by light microscopy in combination with a video overlay system. Atherosclerotic lesions in patients with hyperhomocysteinemia were morphologically similar to those in patients with normal homocysteine levels, except for a significantly decreased smooth muscle cell/extracellular matrix ratio of the media in hyperhomocysteinemic patients (P=0.02 versus normohomocysteinemic atherosclerotic group and P=0.001 versus group without a history of cardiovascular disease). Hyperhomocysteinemia is associated with a significant decrease of the smooth muscle cell/extracellular matrix ratio of the media of muscular femoral arteries without significant changes in medial thickness. Further investigations should concentrate on the cause of this newly discovered phenomenon and its impact on vascular compliance.

Published
2001

3. Decreased smooth muscle cell/extracellular matrix ratio of media of femoral artery in patients with atherosclerosis and hyperhomocysteinemia

Author

Vermeulen, E.G.J., Niessen, H.W.M., Bogels, M., Stehouwer, C.D.A., Rauwerda, J.A., Hinsbergh, V.W.M. van, and Gaubius Instituut TNO

Subjects
Adult, Male, Peripheral Vascular Diseases, Biopsy, Hyperhomocysteinemia, Comorbidity, Middle Aged, Immunohistochemistry, Muscle, Smooth, Vascular, Extracellular Matrix, Femoral Artery, Cardiovascular Diseases, Risk Factors, Humans, Female, Endothelium, Vascular, Homocysteine, Aged
Abstract

The aim of this study was to determine whether the morphology of the muscular femoral artery in patients with atherosclerosis and hyperhomocysteinemia differs from that of atherosclerotic vessels from patients with normal homocysteine levels. Whole-vessel biopsies of the superficial femoral artery were taken from patients with symptomatic atherosclerotic disease with and without hyperhomocysteinemia and from patients without atherosclerosis from traumatic amputations. The morphology of these specimens was studied qualitatively by light and electron microscopy and quantitatively by light microscopy in combination with a video overlay system. Atherosclerotic lesions in patients with hyperhomocysteinemia were morphologically similar to those in patients with normal homocysteine levels, except for a significantly decreased smooth muscle cell/extracellular matrix ratio of the media in hyperhomocysteinemic patients (P=0.02 versus normohomocysteinemic atherosclerotic group and P=0.001 versus group without a history of cardiovascular disease). Hyperhomocysteinemia is associated with a significant decrease of the smooth muscle cell/extracellular matrix ratio of the media of muscular femoral arteries without significant changes in medial thickness. Further investigations should concentrate on the cause of this newly discovered phenomenon and its impact on vascular compliance. Chemicals/CAS: Homocysteine, 454-28-4

Published
2001

4. Evaluation of Peri-tumoral Vessels Surrounding Colorectal Liver Metastases After Intravenous Injection of Extruded Magnetoliposomes in Rats: Correlation With 3t Mri and Histopathology

Author

UCL, Coenegrachts, K., van Werven, J., ter Beek, L., Mzallassi, Z., Bogels, M., Van Gulik, Th., Van den Berghes, I., Nederveen, A., Stoker, J., Rigauts, H., Soenen, S., De Cuyper, M., UCL, Coenegrachts, K., van Werven, J., ter Beek, L., Mzallassi, Z., Bogels, M., Van Gulik, Th., Van den Berghes, I., Nederveen, A., Stoker, J., Rigauts, H., Soenen, S., and De Cuyper, M.

Abstract

Background: Magnetoliposomes have pronounced signal-enhancing effect on T1-weighted (T1w) images of the liver using qualitative analysis which may be benefical for demonstrating peritumoral vasculature. Purpose: To correlate peri-tumoral vasculature (ring-enhancement) surrounding colorectal liver metastases after injection of magnetoliposomes using T1-weighted (T1w) imaging with histopathology in a rat model. Material and Methods: All experiments were approved by the responsible Animal Care Committee. Three rats injected with CC531 coloncarcinoma cells in the portal vein were imaged at 3T using a small diameter four channel coil. The presence of liver metastases, signal intensity changes within intrahepatic vessels, peri-tumoral vasculature (ring-enhancement) surrounding liver metastases on T1w imaging and histopathology, and the histopathological distribution of iron particles were evaluated. SS SE-EPI and T1w GE sequences were used. Images were evaluated qualitatively and MRI findings were correlated with histopathology. Results: Fifteen liver metastases were present which were all detected at MRI (mean diameter 2.4 mm (SD 0.8 mm, range 1.5 -4.7 mm)). Ring-enhancement surrounding liver metastases at contrast-enhanced T1w GE sequences was present in all liver metastases. Correlation with histopathology showed the corresponding presence of dilated sinusoids filled with iron particles surrounding the liver metastases. Conclusion: Blood-pooling of iron oxide particles within magnetoliposomes was demonstrated with increased and hyperintensity of vessels after injection of magnetoliposomes. Qualitatively, ring-enhancement surrounding the liver metastases was seen on T1w imaging and corresponded histopathologically with the presence of iron particles (magnetoliposomes) within the dilated sinusoids surrounding the liver metastases.

Published
2010

6. Surgery-induced reactive oxygen species enhance colon carcinoma cell binding by disrupting the liver endothelial cell lining

Author

Gul, N., primary, Bogels, M., additional, Grewal, S., additional, van der Meer, A. J., additional, Rojas, L. B., additional, Fluitsma, D. M., additional, van den Tol, M. P., additional, Hoeben, K. A., additional, van Marle, J., additional, de Vries, H. E., additional, Beelen, R. H. J., additional, and van Egmond, M., additional

Published
2011
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7. Decreased smooth muscle cell/extracellular matrix ratio of media of femoral artery in patients with atherosclerosis and hyperhomocysteinemia.

Author

Vermeulen EG, Niessen HW, Bogels M, Stehouwer CD, Rauwerda JA, and van Hinsbergh VW

Subjects
Adult, Aged, Biopsy, Cardiovascular Diseases epidemiology, Comorbidity, Endothelium, Vascular cytology, Endothelium, Vascular pathology, Endothelium, Vascular ultrastructure, Extracellular Matrix pathology, Female, Femoral Artery cytology, Femoral Artery ultrastructure, Homocysteine blood, Humans, Hyperhomocysteinemia blood, Hyperhomocysteinemia epidemiology, Immunohistochemistry, Male, Middle Aged, Muscle, Smooth, Vascular pathology, Muscle, Smooth, Vascular ultrastructure, Peripheral Vascular Diseases epidemiology, Risk Factors, Extracellular Matrix ultrastructure, Femoral Artery pathology, Hyperhomocysteinemia pathology, Muscle, Smooth, Vascular cytology, Peripheral Vascular Diseases pathology
Abstract

The aim of this study was to determine whether the morphology of the muscular femoral artery in patients with atherosclerosis and hyperhomocysteinemia differs from that of atherosclerotic vessels from patients with normal homocysteine levels. Whole-vessel biopsies of the superficial femoral artery were taken from patients with symptomatic atherosclerotic disease with and without hyperhomocysteinemia and from patients without atherosclerosis from traumatic amputations. The morphology of these specimens was studied qualitatively by light and electron microscopy and quantitatively by light microscopy in combination with a video overlay system. Atherosclerotic lesions in patients with hyperhomocysteinemia were morphologically similar to those in patients with normal homocysteine levels, except for a significantly decreased smooth muscle cell/extracellular matrix ratio of the media in hyperhomocysteinemic patients (P=0.02 versus normohomocysteinemic atherosclerotic group and P=0.001 versus group without a history of cardiovascular disease). Hyperhomocysteinemia is associated with a significant decrease of the smooth muscle cell/extracellular matrix ratio of the media of muscular femoral arteries without significant changes in medial thickness. Further investigations should concentrate on the cause of this newly discovered phenomenon and its impact on vascular compliance.

Published
2001
Full Text
View/download PDF

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