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1. [Search for anti-inflammatory preparations among the derivatives of succinic acid heteryl amides].

Author

Kabachnyĭ VI, Chernykh VP, Drogovoz SM, Golubenko IuA, and Bogutskaia EE

Subjects
Animals, Drug Evaluation, Preclinical, Edema chemically induced, Edema drug therapy, Formaldehyde, Inflammation chemically induced, Inflammation drug therapy, Mice, Structure-Activity Relationship, Time Factors, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Succinates therapeutic use
Abstract

The antiinflammatory activity and acute toxicity of 44 derivatives of heteryl amides of succinic acid (acids, esters, amides) were studied. This series of compounds was found to be promising for the search of nonsteroidal, practically nontoxic antiphlogistics. The structural-pharmacological analysis was performed and the dependence of the biological effect on the compound structure was revealed.

Published
1987

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