448 results on '"Bohn, Laura M."'
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2. G protein signaling–biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists
3. Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists
4. Pharmacological Diversity in Opioid Analgesics: Lessons From Clinically Useful Drugs
5. Structure–activity relationship investigation of triazole-based kappa opioid receptor agonists
6. Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain
7. Comparison of Agonist Activity between CB1 and CB2 Receptors with Orthosteric Site Mutations.
8. Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures
9. Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics
10. Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation
11. A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal
12. A Novel Method for Analyzing Extremely Biased Agonism at G Protein–Coupled Receptors
13. βArrestins: Ligand-Directed Regulators of 5-HT2A Receptor Trafficking and Signaling Events
14. Crystal Structure of the Human Cannabinoid Receptor CB2
15. 2 - Cellular Receptors and Drug Concentration–Response Relationships
16. Structural and functional insights into the G protein-coupled receptors: CB1 and CB2
17. A Route to Potent, Selective, and Biased Salvinorin Chemical Space
18. Sustained Elevation of Extracellular Dopamine Causes Motor Dysfunction and Selective Degeneration of Striatal GABAergic Neurons
19. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics
20. Glutamatergic Modulation of Hyperactivity in Mice Lacking the Dopamine Transporter
21. Quantitating Ligand Bias Using the Competitive Model of Ligand Activity
22. Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
23. Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine
24. Hyperactivity in mice induced by opioid agonists with partial intrinsic efficacy and biased agonism; alone and in combination with morphine
25. Crystal Structure of the Human Cannabinoid Receptor CB1
26. Biased agonism: An emerging paradigm in GPCR drug discovery
27. β-Arrestins: Regulatory Role and Therapeutic Potential in Opioid and Cannabinoid Receptor-Mediated Analgesia
28. Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus
29. Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting
30. Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif
31. Functional selectivity of GPCR signaling in animals
32. Selectivity for G Protein or Arrestin-Mediated Signaling
33. Contributors
34. Mu Opioid Receptor Regulation and Opiate Responsiveness
35. Approaches to Assess Biased Signaling at the CB1R Receptor
36. Asymmetric Syntheses of (+)- and (−)-Collybolide Enable Reevaluation of kappa-Opioid Receptor Agonism
37. Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors
38. Functional Selectivity of 6′-Guanidinonaltrindole (6′-GNTI) at κ-Opioid Receptors in Striatal Neurons
39. Community guidelines for GPCR ligand bias:IUPHAR review 32
40. GIRK channel modulation by assembly with allosterically regulated RGS proteins
41. β-Arrestin2 Regulates Cannabinoid CB1 Receptor Signaling and Adaptation in a Central Nervous System Region–Dependent Manner
42. Irreversible and noncompetitive mu opioid receptor agonists
43. Advances in Sulfonamide Kappa Opioid Receptor Antagonists: Structural Refinement and Evaluation of CNS Clearance
44. Agonist-Directed Signaling of the Serotonin 2A Receptor Depends on β-Arrestin-2 Interactions in vivo
45. Agonist-directed Interactions with Specific β-Arrestins Determine μ-Opioid Receptor Trafficking, Ubiquitination, and Dephosphorylation
46. The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics
47. Community guidelines for GPCR ligand bias: IUPHAR review 32
48. Approaches to Assess Functional Selectivity in GPCRs: Evaluating G Protein Signaling in an Endogenous Environment
49. Seeking ligand bias: assessing GPCR coupling to β-arrestins for drug discovery
50. A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1
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