Search

This study presents a unique methodology for dementia classification that harnesses voice data and integrates transfer learning, feature selection, and attention-based visualization. We examined two deep learning input techniques: one consolidating three Melspectrograms (standard, Harmonic/Percussive average, and delta value) into an integrated image and the other assessing them individually.This study validates the efficacy of melt spectrogram image classification using Gradient-weighted Class Activation Mapping (Grad-CAM) for feature selection. This study exploited the Grad-CAM attention map to pinpoint the Melspectrogram's most impactful features. Evaluations illustrated that the combined synthetic images yielded 1.4% - 9.4% better accuracy than the separate images. Implementing Grad-CAM for feature selection further amplifies accuracy. Models utilizing features identified by Grad-CAM averaged a 4.3% superior accuracy compared with solely fine-tuned models. With integrated mel-spectrograms as input, the classification accuracies for Normal vs. Dementia, Normal vs. Mild Cognitive Impairment, and Dementia vs. Mild Cognitive Impairment were 75%, 67.9%, and 67.8%, respectively, indicating an improvement of up to 13.1% compared to individual images.

IntroductionAttention-deficit/hyperactivity disorder (ADHD) affects a significant proportion of the pediatric population, making early detection crucial for effective intervention. Eye movements are controlled by brain regions associated with neuropsychological functions, such as selective attention, response inhibition, and working memory, and their deficits are related to the core characteristics of ADHD. Herein, we aimed to develop a screening model for ADHD using machine learning (ML) and eye-tracking features from tasks that reflect neuropsychological deficits in ADHD.MethodsFifty-six children (mean age 8.38 ± 1.58, 45 males) diagnosed with ADHD based on the Diagnostic and Statistical Manual of Mental Disorders, fifth edition were recruited along with seventy-nine typically developing children (TDC) (mean age 8.80 ± 1.82, 33 males). Eye-tracking data were collected using a digital device during the performance of five behavioral tasks measuring selective attention, working memory, and response inhibition (pro-saccade task, anti-saccade task, memory-guided saccade task, change detection task, and Stroop task). ML was employed to select relevant eye-tracking features for ADHD, and to subsequently construct an optimal model classifying ADHD from TDC.ResultsWe identified 33 eye-tracking features in the five tasks with the potential to distinguish children with ADHD from TDC. Participants with ADHD showed increased saccade latency and degree, and shorter fixation time in eye-tracking tasks. A soft voting model integrating extra tree and random forest classifiers demonstrated high accuracy (76.3%) at identifying ADHD using eye-tracking features alone. A comparison of the model using only eye-tracking features with models using the Advanced Test of Attention or Stroop test showed no significant difference in the area under the curve (AUC) (p = 0.419 and p=0.235, respectively). Combining demographic, behavioral, and clinical data with eye-tracking features improved accuracy, but did not significantly alter the AUC (p=0.208).DiscussionOur study suggests that eye-tracking features hold promise as ADHD screening tools, even when obtained using a simple digital device. The current findings emphasize that eye-tracking features could be reliable indicators of impaired neurobiological functioning in individuals with ADHD. To enhance utility as a screening tool, future research should be conducted with a larger sample of participants with a more balanced gender ratio.

Economic forecasting is crucial since it benefits many different parties, such as governments, businesses, investors, and the general public. This paper presents a novel methodology for forecasting business cycles using an autoregressive integrated moving average (ARIMA), a popular linear model in time series forecasting, and a neural network with weighted fuzzy membership functions (NEWFM) as a forecasting model generator. The study used a dataset that included seven components of the leading composite index, which is used to predict positive or negative trends in several economic sectors before the GDP is compiled. The preprocessed time series data comprising the leading composite index using ARIMA were used as input vectors for the NEWFM to predict comprehensive business fluctuations. The prediction capability significantly improved through the duplicated refining process of the dataset using ARIMA and NEWFM. The combined ARIMA and NEWFM techniques exceeded ARIMA in both classification and prediction, yielding an accuracy of 91.61%.

BackgroundLack of quantifiable biomarkers is a major obstacle in diagnosing and treating depression. In adolescents, increasing suicidality during antidepressant treatment further complicates the problem. ObjectiveWe sought to evaluate digital biomarkers for the diagnosis and treatment response of depression in adolescents through a newly developed smartphone app. MethodsWe developed the Smart Healthcare System for Teens At Risk for Depression and Suicide app for Android-based smartphones. This app passively collected data reflecting the social and behavioral activities of adolescents, such as their smartphone usage time, physical movement distance, and the number of phone calls and text messages during the study period. Our study consisted of 24 adolescents (mean age 15.4 [SD 1.4] years, 17 girls) with major depressive disorder (MDD) diagnosed with Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version and 10 healthy controls (mean age 13.8 [SD 0.6] years, 5 girls). After 1 week’s baseline data collection, adolescents with MDD were treated with escitalopram in an 8-week, open-label trial. Participants were monitored for 5 weeks, including the baseline data collection period. Their psychiatric status was measured every week. Depression severity was measured using the Children’s Depression Rating Scale-Revised and Clinical Global Impressions-Severity. The Columbia Suicide Severity Rating Scale was administered in order to assess suicide severity. We applied the deep learning approach for the analysis of the data. Deep neural network was employed for diagnosis classification, and neural network with weighted fuzzy membership functions was used for feature selection. ResultsWe could predict the diagnosis of depression with training accuracy of 96.3% and 3-fold validation accuracy of 77%. Of the 24 adolescents with MDD, 10 responded to antidepressant treatments. We predicted the treatment response of adolescents with MDD with training accuracy of 94.2% and 3-fold validation accuracy of 76%. Adolescents with MDD tended to move longer distances and use smartphones for longer periods of time compared to controls. The deep learning analysis showed that smartphone usage time was the most important feature in distinguishing adolescents with MDD from controls. Prominent differences were not observed in the pattern of each feature between the treatment responders and nonresponders. The deep learning analysis revealed that the total length of calls received as the most important feature predicting antidepressant response in adolescents with MDD. ConclusionsOur smartphone app demonstrated preliminary evidence of predicting diagnosis and treatment response in depressed adolescents. This is the first study to predict the treatment response of adolescents with MDD by examining smartphone-based objective data with deep learning approaches.

Feature selection is an important technique that simplifies machine learning models to easily understand, shorten learning time, and reduce curve over-fitting or under-fitting. This paper presents a shape selection algorithm based on a method of investigating similarities between sampled shape values for classification variables (classes). This is based on the premise that the lower the similarity, the higher the usefulness of class classification. The confidence interval of a normal distribution is used to measure similarity. It is judged that the more overlapping the confidence intervals, the higher the similarity. The smaller the duplication of the confidence interval, the lower the similarity, and if the similarity is low, it can be used as a criterion for classification. Therefore, I propose an equation to apply this method. To confirm the usefulness of the equation, a colorectal cancer dataset with about 2000 genes was used and comparative experiments were performed with other feature selection algorithms. The comparison algorithms were Gini Index (10 features), mRMR (10 features), and relational matrix algorithms (7 features). Artificial neural networks were generally used as machine learning algorithms, and comparative verification was performed based on the rib one-out cross-validation method. As a result of the experiment, the results of the Gini index (85.487%), mRMR (87.09%), and relational matrix algorithms (87.09%) were better than those of 88.71% by selecting 10 features. In addition, experiments on iris, wine, glass, music emotions, seeds, and Japanese collection datasets were conducted on multiple classification problems. In the case of wine, the accuracy was 98.8% when all functions were used, but six functions were removed, resulting in 99.4% accuracy. In the case of music sensitivity, the accuracy was 51.7% when all 54 features were used, but when 20 features were removed, it improved to 61.3%. In the case of seeds, it was found that when the number of seeds decreased from 7 to 5, it slightly improved from 93.3% to 93.8%. In the case of iris, glass, and Japanese vowels, the accuracy did not increase even though the function was removed. Therefore, it can be concluded that features can be easily and effectively selected from the multi-class classification problem using the method proposed in this paper.

In this study, we propose a method to automatically find features from a dataset that are effective for classification or prediction, using a new method called multi-agent reinforcement learning and a guide agent. Each feature of the dataset has one of the main and guide agents, and these agents decide whether to select a feature. Main agents select the optimal features, and guide agents present the criteria for judging the main agents’ actions. After obtaining the main and guide rewards for the features selected by the agents, the main agent that behaves differently from the guide agent updates their Q-values by calculating the learning reward delivered to the main agents. The behavior comparison helps the main agent decide whether its own behavior is correct, without using other algorithms. After performing this process for each episode, the features are finally selected. The feature selection method proposed in this study uses multiple agents, reducing the number of actions each agent can perform and finding optimal features effectively and quickly. Finally, comparative experimental results on multiple datasets show that the proposed method can select effective features for classification and increase classification accuracy.

Deep neural networks have been successfully applied to generate predictive patterns from medical and diagnostic data. This paper presents an approach for assessing persons with Alzheimer’s disease (AD) mild cognitive impairment (MCI), compared with normal control (NC) persons, using the zoom-in neural network (ZNN) deep-learning algorithm. ZNN stacks a set of zoom-in learning units (ZLUs) in a feedforward hierarchy without backpropagation. The resting-state fMRI (rs-fMRI) dataset for AD assessments was obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The Automated Anatomical Labeling (AAL-90) atlas, which provides 90 neuroanatomical functional regions, was used to assess and detect the implicated regions in the course of AD. The features of the ZNN are extracted from the 140-time series rs-fMRI voxel values in a region of the brain. ZNN yields the three classification accuracies of AD versus MCI and NC, NC versus AD and MCI, and MCI versus AD and NC of 97.7%, 84.8%, and 72.7%, respectively, with the seven discriminative regions of interest (ROIs) in the AAL-90.

Finding the minimum number of appropriate biomarkers for specific targets such as a lung cancer has been a challenging issue in bioinformatics. We propose a hierarchical two-phase framework for selecting appropriate biomarkers that extracts candidate biomarkers from the cancer microarray datasets and then selects the minimum number of appropriate biomarkers from the extracted candidate biomarkers datasets with a specific neuro-fuzzy algorithm, which is called a neural network with weighted fuzzy membership function (NEWFM). In this context, as the first phase, the proposed framework is to extract candidate biomarkers by using a Bhattacharyya distance method that measures the similarity of two discrete probability distributions. Finally, the proposed framework is able to reduce the cost of finding biomarkers by not receiving medical supplements and improve the accuracy of the biomarkers in specific cancer target datasets. [ABSTRACT FROM AUTHOR]