Search

Retroperitoneal liposarcoma is a rare type of tumor characterized by slow growth and nonspecific symptoms, and is usually diagnosed at an advanced stage. Patients with huge retroperitoneal liposarcoma have a high risk of developing perioperative complications, and require special preoperative preparation and a carefully planned anesthetic approach. We present the case of a 57-year-old man, who was diagnosed with a huge retroperitoneal liposarcoma, 70 cm in diameter, weighing 30.4 kg and planned for surgical resection of the tumor under general anesthesia. Perioperative treatment and anesthesia for this patient were a great challenge for the anesthesiologist. However, due to preoperative preparation, monitoring and fluid replacement, hemodynamic and respiratory stability of the patient was maintained perioperatively.

Previous studies have shown that exposure to adverse life events is positively associated with a tendency towards antisocial behavior. However, results concerning relationships between antisocial behaviour and internal factors, such as personality traits, are not so consistent. The present study aimed to examine the effects of negative life events and Dark Tetrad traits (narcissism, Machiavellianism, psychopathy, and sadism) on different antisocial behaviors, including norm-breaking, aggression, vandalism, and drug use. The sample included 221 high school students (66% females) from three cities in Serbia. Results showed that negative life events significantly predicted norm-breaking, aggression, and vandalism, while such life events’ power to predict drug use ceased once the dark traits were added to the regression model. In the case of dark traits, narcissism, psychopathy, and sadism positively predicted norm-breaking and aggression, while sadism also predicted vandalism. Machiavellianism did not significantly predict any of the antisocial behaviors. Тhe results suggest that norm-breaking is largely explained by both negative life events and personality traits. Aggression, on the other hand, is better explained by personality traits. Finally, the examined factors contribute much less to the explanation of vandalism and drug use.The results are discussed in the context of possible prevention of antisocial behavior in adolescents.

Central sensitization (CS) involves an amplification of neural processing within the central nervous system that can result in widespread pain patterns and hypersensitivity to stimuli. The Central Sensitization Inventory (CSI) and various quantitative sensory testing (QST) methods purport to assess clinical markers of CS. The purpose of this systematic review and meta-analysis was to summarize and quantify the associations between total CSI scores and QST measures from previous studies. A systematic search identified 39 unique studies that were deemed eligible for the systematic review and 33 studies for meta-analyses (with 3314 subjects and 154 effect sizes), including five QST modalities: conditioned pain modulation, temporal summation, pressure pain threshold, heat pain threshold, and cold pain threshold. The meta-analysis yielded statistically significant CSI-QST correlations in total subject samples for all five QST modalities. The strongest associations were identified between CSI scores and pain threshold testing, especially pressure pain threshold, in which 51% of effects sizes, from 29 studies and 3071 subjects, were determined to be in a medium to large range., Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest., (Copyright © 2024 Elsevier Ltd. All rights reserved.)