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297 results on '"Bokhan, Nikolay A."'

3. NOS1AP Gene Variants and Their Role in Metabolic Syndrome: A Study of Patients with Schizophrenia

Author

Mednova, Irina A., primary, Pozhidaev, Ivan V., additional, Tiguntsev, Vladimir V., additional, Bocharova, Anna V., additional, Paderina, Diana Z., additional, Boiko, Anastasiia S., additional, Fedorenko, Olga Y., additional, Kornetova, Elena G., additional, Bokhan, Nikolay A., additional, Stepanov, Vadim A., additional, and Ivanova, Svetlana A., additional

Published
2024
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6. Hormones, oxidized proteins, and lipids in alcoholism. Duration of remission.

Author

Vetlugina, Tamara P., Prokopieva, Valentina D., Bokhan, Nikolay A., Nikitina, Valentina B., Lobacheva, Olga A., and Mandel, Anna I.

Subjects
REHABILITATION of people with alcoholism, PROTEINS, TESTOSTERONE, HORMONES, RESEARCH funding, INTERVIEWING, OXIDATIVE stress, HYDROCORTISONE, LIPID peroxidation (Biology), REMISSION induction, TRIIODOTHYRONINE, THYROTROPIN
Abstract

The instability of remission in alcohol dependence (AD) creates a need to search for criteria for predicting its duration. The aim of study was to determine the hormones, oxidized proteins, and lipids in patients with AD, and the possible relations between these parameters and the duration of remission. Blood samples were obtained from 49 male patients with AD after alcohol detoxification (Total group). Two groups of patients were formed: with unstable therapeutic remission up to 6 months (UTR-group); with stable therapeutic remission which lasted 12 months or longer (STR-group). The control group comprised men without AD. The levels of carbonylated proteins (CP), lipid peroxidation (TBA-RS) were determined in the blood plasma. The levels of cortisol, testosterone total, thyroid-stimulating hormone (TSH), triiodothyronine free (fT3), and thyroxine free (fT4) in the blood serum were measured. The Total group of patients showed an increase in CP, TBA-RS, Cortisol, cortisol/testosterone ratio, and a decrease in TSH, fT3, and fT3/fT4 levels. A set of parameters (T, fT3, fT4, cortisol/testosterone ratio) associated with unstable remission was identified. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Opening up new horizons for psychiatric genetics in the Russian Federation: moving toward a national consortium

Author

Fedorenko, Olga Yu., Golimbet, Vera E., Ivanova, Svetlana А., Levchenko, Аnastasia, Gainetdinov, Raul R., Semke, Arkady V., Simutkin, German G., Gareeva, Аnna E., Glotov, Аndrey S., Gryaznova, Anna, Iourov, Ivan Y., Krupitsky, Evgeny M., Lebedev, Igor N., Mazo, Galina E., Kaleda, Vasily G., Abramova, Lilia I., Oleichik, Igor V., Nasykhova, Yulia A., Nasyrova, Regina F., Nikolishin, Anton E., Kasyanov, Evgeny D., Rukavishnikov, Grigory V., Timerbulatov, Ilgiz F., Brodyansky, Vadim M., Vorsanova, Svetlana G., Yurov, Yury B., Zhilyaeva, Tatyana V., Sergeeva, Anzhelika V., Blokhina, Elena A., Zvartau, Edwin E., Blagonravova, Anna S., Aftanas, Lyubomir I., Bokhan, Nikolay А., Kekelidze, Zurab I., Klimenko, Tatyana V., Anokhina, Irina P., Khusnutdinova, Elza K., Klyushnik, Tatyana P., Neznanov, Nikolay G., Stepanov, Vadim A., Schulze, Thomas G., and Kibitov, Аleksandr О.

Published
2019
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31. The Gender-Specific Association of DRD2 Polymorphism with Metabolic Syndrome in Patients with Schizophrenia

Author

Paderina, Diana Z., primary, Boiko, Anastasiia S., additional, Pozhidaev, Ivan V., additional, Mednova, Irina A., additional, Goncharova, Anastasia A., additional, Bocharova, Anna V., additional, Fedorenko, Olga Yu., additional, Kornetova, Elena G., additional, Semke, Arkadiy V., additional, Bokhan, Nikolay A., additional, Loonen, Anton J. M., additional, and Ivanova, Svetlana A., additional

Published
2022
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33. Genes of the Glutamatergic System and Tardive Dyskinesia in Patients with Schizophrenia

Author

Fedorenko, Olga Yu., primary, Paderina, Diana Z., additional, Kornetova, Elena G., additional, Poltavskaya, Evgeniya G., additional, Pozhidaev, Ivan V., additional, Goncharova, Anastasiia A., additional, Freidin, Maxim B., additional, Bocharova, Anna V., additional, Bokhan, Nikolay A., additional, Loonen, Anton J. M., additional, and Ivanova, Svetlana A., additional

Published
2022
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35. Cytokine level in patients with mood disorder, alcohol use disorder and their comorbidity.

Author

Mednova, Irina A., Levchuk, Lyudmila A., Boiko, Anastasiia S., Roschina, Olga V., Simutkin, German G., Bokhan, Nikolay A., Loonen, Anton J. M., and Ivanova, Svetlana A.

Subjects
ALCOHOLISM, AFFECTIVE disorders, ALCOHOL drinking, CYTOKINES, IMMUNE system
Abstract

Because alcohol use disorder (AUD) is often accompanied by mood disorder (MD) and both alcoholism and depression result in activation of the immune system, this study compares serum cytokine levels in the presence of co-morbidity with those in either AUD or MD alone. In this naturalistic prospective study the levels of 15 different cytokines were measured in serum samples of patients with MD (n = 43), participants with combined AUD-MD (n = 44) and AUD without MD (n = 42). The levels were compared cross-sectionally among themselves and with those in 50 healthy volunteers. Pro-inflammatory IFN-2α levels were consistently significantly higher and anti-inflammatory IL-1RA significantly lower in all study groups in comparison to healthy volunteers. In the MD only group we found increased IL-6 (p = 0.001), IL-7 (p = 0.001) and IL-13 (p = 0.006) levels, and decreased TNFα (p = 0.0001), IL-1RA (p = 0.012), IL-10 (p = 0.002) compared with group MD + AUD. Patients with AUD only showed elevated levels of IL-1β (p = 0.046), IL-2 (p = 0.004), IL-7 (p = 0.0001), IL-4 (p = 0.049) and IL-13 (p = 0.015) in contrast with MD + AUD group. Because the interactions of alcohol with peripheral and cerebral immune systems are multifaceted, the pertinent connection to the mechanism how alcohol consumption contributes to the development of mood disorders cannot be properly explored. [ABSTRACT FROM AUTHOR]

Published
2023
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36. The habenular volume and PDE7A allelic polymorphism in major depressive disorder: preliminary findings.

Author

Aftanas, Lyubomir I., Filimonova, Elena A., Anisimenko, Maksim S., Berdyugina, Darya A., Rezakova, Maria V., Simutkin, German G., Bokhan, Nikolay A., Ivanova, Svetlana A., Danilenko, Konstantin V., and Lipina, Tatiana V.

Subjects
MENTAL depression, BRAIN physiology, MAGNETIC resonance imaging, SINGLE nucleotide polymorphisms, BODY mass index, BRAIN anatomy
Abstract

The habenula is a brain structure implicated in depression, yet with unknown molecular mechanisms. Several phosphodiesterases (PDEs) have been associated with a risk of depression. Although the role of PDE7A in the brain is unknown, it has enriched expression in the medial habenula, suggesting that it may play a role in depression. We analysed: (1) habenula volume assessed by 3-T magnetic resonance imaging (MRI) in 84 patients with major depressive disorder (MDD) and 41 healthy controls; (2) frequencies of 10 single nucleotide polymorphisms (SNPs) in PDE7A gene in 235 patients and 41 controls; and (3) both indices in 80 patients and 27 controls. The analyses considered gender, age, body mass index and season of the MRI examination. The analysis did not reveal habenula volumetric changes in MDD patients regardless of PDE7A SNPs. However, in the combined group, the carriers of one or more mutations among 10 SNPs in the PDE7A gene had a lower volume of the left habenula (driven mainly by rs972362 and rs138599850 mutations) and consequently had the reduced habenular laterality index in comparison with individuals without PDE7A mutations. Our findings suggest the implication of the PDE7A gene into mechanisms determining the habenula structure. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome

Author

Boiko, Anastasiia S., primary, Pozhidaev, Ivan V., additional, Paderina, Diana Z., additional, Mednova, Irina A., additional, Goncharova, Anastasya A., additional, Fedorenko, Olga Yu., additional, Kornetova, Elena G., additional, Semke, Arkadiy V., additional, Bokhan, Nikolay A., additional, Loonen, Anton J. M., additional, and Ivanova, Svetlana A., additional

Published
2022
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38. Cortisol and DHEAS Related to Metabolic Syndrome in Patients with Schizophrenia

Author

Boiko, Anastasiia S, Mednova, Irina A, Kornetova, Elena G, Bokhan, Nikolay A, Semke, Arkadiy V, Loonen, Anton J M, Ivanova, Svetlana A, PharmacoTherapy, -Epidemiology and -Economics, and Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)

Subjects
RISK, GENDER-DIFFERENCES, Neuropsychiatric Disease and Treatment, BIPOLAR DISORDER, cortisol, metabolic syndrome, schizophrenia, RATIO, dehydroepiandrosterone, female, TISSUE, TESTOSTERONE, DEHYDROEPIANDROSTERONE DHEA, HEALTH, acute relapse, METAANALYSIS, Original Research
Abstract

Anastasiia S Boiko,1 Irina A Mednova,1 Elena G Kornetova,1,2 Nikolay A Bokhan,1,3 Arkadiy V Semke,1 Anton JM Loonen,4 Svetlana A Ivanova1,3 1Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation; 2Hospital, Siberian State Medical University, Tomsk, Russian Federation; 3Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, Russian Federation; 4PharmacoTherapy, -Epidemiology and -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The NetherlandsCorrespondence: Anton JM LoonenPharmacoTherapy, Epidemiology and Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The NetherlandsTel + 31 50 363 7576Fax + 31 50 363 2772Email a.j.m.loonen@rug.nlBackground: Bothdehydroepiandrosterone (DHEAS) and cortisol are secreted by the adrenal glands and may modulate metabolic syndrome (MetS), which often affects the health of patients with schizophrenia. The relationship between the serum levels of these hormones and MetS has not been established.Purpose: In this pilot study, we investigated the serum levels in schizophrenia patients with and without MetS and compared them with those in healthy volunteers.Patients and Methods: After obtaining informed consent, 110 patients with acute paranoid schizophrenia were recruited directly after admission to the Mental Health Research Institute. The control group consisted of 51 persons reported on questioning to be mentally and somatically healthy. Blood samples to prepare serum were drawn after an 8-h overnight fast during one of the first days of admission. Serum cortisol and DHEAS concentrations were quantified by enzyme-linked immunosorbent assay.Results: A total of 42 patients had MetS and 68 patients were without MetS. The cortisol blood level was significantly (p = 0.012) higher in schizophrenia patients without MetS in comparison to healthy controls, while patients with schizophrenia and a MetS have significantly (p = 0.014) lower DHEAS levels than healthy volunteers. These differences could, however, exclusively be attributed to female participants. Analysis of covariance adjusted for gender and age demonstrated a significant relationship between age and DHEAS levels (F = 9.512, р = 0.003).Conclusion: Lower DHEAS serum levels in relationship to MetS become evident in women, but not in men, and have age differences as a confounding factor.Keywords: schizophrenia, metabolic syndrome, acute relapse, cortisol, dehydroepiandrosterone, female

Published
2020

40. A New Paradigm to Indicate Antidepressant Treatments

Author

Loonen, Anton, primary, Ochi, Taichi, additional, Geers, Lisanne, additional, Simutkin, German, additional, Bokhan, Nikolay, additional, Touw, Daniël, additional, Wilffert, Bob, additional, Kornetov, Alexander, additional, and Ivanova, Svetlana, additional

Published
2021
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43. Influence of eight ABCB1 polymorphisms on antidepressant response in a prospective cohort of treatment‐free Russian patients with moderate or severe depression: An explorative psychopharmacological study with naturalistic design

Author

Geers, Lisanne M., primary, Ochi, Taichi, additional, Vyalova, Natalya M., additional, Losenkov, Innokentiy S., additional, Paderina, Diana Z., additional, Pozhidaev, Ivan V., additional, Simutkin, German G., additional, Bokhan, Nikolay A., additional, Wilffert, Bob, additional, Touw, Daniël J., additional, Loonen, Anton J.M., additional, and Ivanova, Svetlana A., additional

Published
2021
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46. Search for Possible Associations of FTO Gene Polymorphic Variants with Metabolic Syndrome, Obesity and Body Mass Index in Schizophrenia Patients

Author

Boiko, Anastasiia S, primary, Pozhidaev, Ivan, additional, Paderina, Diana Z, additional, Bocharova, Anna V, additional, Mednova, Irina A, additional, Fedorenko, Olga Yu, additional, Kornetova, Elena G, additional, Loonen, Anton JM, additional, Semke, Arkadiy V, additional, Bokhan, Nikolay A, additional, and Ivanova, Svetlana A, additional

Published
2021
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48. Comparative Characteristics of the Metabolic Syndrome Prevalence in Patients With Schizophrenia in Three Western Siberia Psychiatric Hospitals

Author

Kornetova, Elena G., primary, Kornetov, Alexander N., additional, Mednova, Irina A., additional, Goncharova, Anastasia A., additional, Gerasimova, Valeria I., additional, Pozhidaev, Ivan V., additional, Boiko, Anastasiia S., additional, Semke, Arkadiy V., additional, Loonen, Anton J. M., additional, Bokhan, Nikolay A., additional, and Ivanova, Svetlana A., additional

Published
2021
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49. Search for Possible Associations of FTO Gene Polymorphic Variants with Metabolic Syndrome, Obesity and Body Mass Index in Schizophrenia Patients

Author

Boiko,Anastasiia S, Pozhidaev,Ivan, Paderina,Diana Z, Bocharova,Anna V, Mednova,Irina A, Fedorenko,Olga Yu, Kornetova,Elena G, Loonen,Anton JM, Semke,Arkadiy V, Bokhan,Nikolay A, Ivanova,Svetlana A, Boiko,Anastasiia S, Pozhidaev,Ivan, Paderina,Diana Z, Bocharova,Anna V, Mednova,Irina A, Fedorenko,Olga Yu, Kornetova,Elena G, Loonen,Anton JM, Semke,Arkadiy V, Bokhan,Nikolay A, and Ivanova,Svetlana A

Abstract

Anastasiia S Boiko,1,* Ivan V Pozhidaev,1,* Diana Z Paderina,1 Anna V Bocharova,2 Irina A Mednova,1 Olga Yu Fedorenko,1 Elena G Kornetova,3,4 Anton JM Loonen,5 Arkadiy V Semke,3 Nikolay A Bokhan,6,7 Svetlana A Ivanova1,7 1Molecular Genetics and Biochemistry Laboratory, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation; 2Laboratory of Evolutionary Genetics, Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation; 3Endogenous Disorders Department, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation; 4University Hospital, Siberian State Medical University, Tomsk, Russian Federation; 5Unit of Pharmacotherapy, Epidemiology & Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, the Netherlands; 6Addictive Disorders Department, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation; 7Psychiatry, Addiction Psychiatry and Psychotherapy Department, Siberian State Medical University, Tomsk, Russian Federation*These authors contributed equally to this workCorrespondence: Anton JM LoonenUnit of Pharmacotherapy, Epidemiology & Economics, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, Groningen, 9713AV, the NetherlandsTel +31 50 363 7576Email a.j.m.loonen@rug.nlPurpose: Metabolic syndrome (MetS) is characterized by abdominal obesity, hyperglycaemia, dyslipidaemia and hypertension. FTO gene has been implicated in the pathogenesis of obesity, but the available scientific data concerning their relationship to antipsychotic drug-induced obesity and metabolic syndrome is still incomplete and inconsistent, which indicates that continuing the investig

Published
2021

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