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449 results on '"Boldt, Leif-Hendrik"'

1. Converting PROMIS®-29 v2.0 profile data to SF-36 physical and mental component summary scores in patients with cardiovascular disorders

Author

Liegl, Gregor, H. Fischer, Felix, N. Martin, Carl, Rönnefarth, Maria, Blumrich, Annelie, Ahmadi, Michael, Boldt, Leif-Hendrik, Eckardt, Kai-Uwe, Endres, Matthias, Edelmann, Frank, Gerhardt, Holger, Grittner, Ulrike, Haghikia, Arash, Hübner, Norbert, Landmesser, Ulf, Leistner, David, Mai, Knut, Kollmus-Heege, Jil, N. Müller, Dominik, H. Nolte, Christian, K. Piper, Sophie, M. Schmidt-Ott, Kai, Pischon, Tobias, Rattan, Simrit, Rohrpasser-Napierkowski, Ira, Schönrath, Katharina, Schulz-Menger, Jeanette, Schweizerhof, Oliver, Spranger, Joachim, E. Weber, Joachim, Witzenrath, Martin, Schmidt, Sein, and Rose, Matthias

Published
2024
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2. Semi-automated reproducible target transfer for cardiac radioablation – A multi-center cross-validation study within the RAVENTA trial

Author

Hohmann, Stephan, Xie, Jingyang, Eckl, Miriam, Grehn, Melanie, Karfoul, Nizar, Janorschke, Christian, Merten, Roland, Rudic, Boris, Buergy, Daniel, Lyan, Evgeny, Krug, David, Mehrhof, Felix, Boldt, Leif-Hendrik, Corradini, Stefanie, Fanslau, Hannah, Kaestner, Lena, Zaman, Adrian, Giordano, Frank A., Duncker, David, Dunst, Jürgen, Tilz, Roland R., Schweikard, Achim, Blanck, Oliver, and Boda-Heggemann, Judit

Published
2024
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4. Radiosurgery for ventricular tachycardia (RAVENTA): interim analysis of a multicenter multiplatform feasibility trial

Author

Krug, David, Zaman, Adrian, Eidinger, Lina, Grehn, Melanie, Boda-Heggemann, Judit, Rudic, Boris, Mehrhof, Felix, Boldt, Leif-Hendrik, Hohmann, Stephan, Merten, Roland, Buergy, Daniel, Fleckenstein, Jens, Kluge, Anne, Rogge, Annette, Both, Marcus, Rades, Dirk, Tilz, Roland Richard, Olbrich, Denise, König, Inke R., Siebert, Frank-Andre, Schweikard, Achim, Vonthein, Reinhard, Bonnemeier, Hendrik, Dunst, Jürgen, and Blanck, Oliver

Published
2023
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5. The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies

Author

Hoffmann, Julia, Hanß, Sabine, Kraus, Monika, Schaller, Jens, Schäfer, Christian, Stahl, Dana, Anker, Stefan D., Anton, Gabriele, Bahls, Thomas, Blankenberg, Stefan, Blumentritt, Arne, Boldt, Leif-Hendrik, Cordes, Steffen, Desch, Steffen, Doehner, Wolfram, Dörr, Marcus, Edelmann, Frank, Eitel, Ingo, Endres, Matthias, Engelhardt, Stefan, Erdmann, Jeanette, Eulenburg, Katharina, Falk, Volkmar, Felix, Stephan B., Frank, Derk, Franke, Thomas, Frey, Norbert, Friede, Tim, Geidel, Lars, Germans, Lisa, Grabmaier, Ulrich, Halle, Martin, Hausleiter, Jörg, Jakobi, Vera, Jebran, Ahmad-Fawad, Jobs, Alexander, Kääb, Stefan, Karakas, Mahir, Katus, Hugo A., Klatt, Alexandra, Knosalla, Christoph, Krebser, Joachim, Landmesser, Ulf, Lee, Mahsa, Lehnert, Kristin, Lesser, Stephanie, Leyh, Katrin, Lorbeer, Roberto, Mach-Kolb, Stephanie, Meder, Benjamin, Nagel, Eike, Nolte, Christian H., Parwani, Abdul S., Petersmann, Astrid, Puls, Miriam, Rau, Henriette, Reiser, Maximilian, Rienhoff, Otto, Scharfe, Tabea, Schattschneider, Mario, Scheel, Heiko, Schnabel, Renate B., Schuster, Andreas, Schmitt, Boris, Seidler, Tim, Seiffert, Moritz, Stähli, Barbara-Elisabeth, Stas, Adriane, J. Stocker, Thomas, von Stülpnagel, Lukas, Thiele, Holger, Wachter, Rolf, Wakili, Reza, Weis, Tanja, Weitmann, Kerstin, Wichmann, Heinz-Erich, Wild, Philipp, Zeller, Tanja, Hoffmann, Wolfgang, Zeisberg, Elisabeth Maria, Zimmermann, Wolfram-Hubertus, Krefting, Dagmar, Kühne, Titus, Peters, Annette, Hasenfuß, Gerd, Massberg, Steffen, Sommer, Thomas, Dimmeler, Stefanie, Eschenhagen, Thomas, and Nauck, Matthias

Published
2023
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9. TandemHeart pLVAD

Author

Boldt, Leif-Hendrik, Tschöpe, Carsten, Spillmann, Frank, Boeken, Udo, editor, Assmann, Alexander, editor, Klotz, Stefan, editor, Born, Frank, editor, Rieth, Andreas, editor, and Schmid, Christof, editor

Published
2020
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11. Cardiac arrhythmias in patients with COVID-19: Lessons from 2300 telemetric monitoring days on the intensive care unit

Author

Parwani, Abdul Shokor, Haug, Marcel, Keller, Theresa, Guthof, Tim, Blaschke, Florian, Tscholl, Verena, Biewener, Sebastian, Kamieniarz, Paul, Zieckler, Daniel, Kruse, Jan, Angermair, Stefan, Treskatsch, Sascha, Müller-Redetzky, Holger, Pieske, Burkert, Stangl, Karl, Landmesser, Ulf, Boldt, Leif-Hendrik, Huemer, Martin, and Attanasio, Philipp

Published
2021
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13. Converting PROMIS®-29 v2.0 profile data to SF-36 physical and mental component summary scores in patients with cardiovascular disorders.

Author

Liegl, Gregor, H. Fischer, Felix, N. Martin, Carl, Rönnefarth, Maria, Blumrich, Annelie, Ahmadi, Michael, Boldt, Leif-Hendrik, Eckardt, Kai-Uwe, Endres, Matthias, Edelmann, Frank, Gerhardt, Holger, Grittner, Ulrike, Haghikia, Arash, Hübner, Norbert, Landmesser, Ulf, Leistner, David, Mai, Knut, Kollmus-Heege, Jil, N. Müller, Dominik, and H. Nolte, Christian

Subjects
QUALITY of life, REGRESSION analysis, CARDIOVASCULAR diseases, TEST validity, HEALTH surveys
Abstract

Background: Health-related quality of life (HRQL) has become an important outcome parameter in cardiology. The MOS 36-ltem Short-Form Health Survey (SF-36) and the PROMIS-29 are two widely used generic measures providing composite HRQL scores. The domains of the SF-36, a well-established instrument utilized for several decades, can be aggregated to physical (PCS) and mental (MCS) component summary scores. Alternative scoring algorithms for correlated component scores (PCSc and MCSc) have also been suggested. The PROMIS-29 is a newer but increasingly used HRQL measure. Analogous to the SF-36, physical and mental health summary scores can be derived from PROMIS-29 domain scores, based on a correlated factor solution. So far, scores from the PROMIS-29 are not directly comparable to SF-36 results, complicating the aggregation of research findings. Thus, our aim was to provide algorithms to convert PROMIS-29 data to well-established SF-36 component summary scores. Methods: Data from n = 662 participants of the Berlin Long-term Observation of Vascular Events (BeLOVE) study were used to estimate linear regression models with either PROMIS-29 domain scores or aggregated PROMIS-29 physical/mental health summary scores as predictors and SF-36 physical/mental component summary scores as outcomes. Data from a subsequent assessment point (n = 259) were used to evaluate the agreement between empirical and predicted SF-36 scores. Results: PROMIS-29 domain scores as well as PROMIS-29 health summary scores showed high predictive value for PCS, PCSc, and MCSc (R2 ≥ 70%), and moderate predictive value for MCS (R2 = 57% and R2 = 40%, respectively). After applying the regression coefficients to new data, empirical and predicted SF-36 component summary scores were highly correlated (r > 0.8) for most models. Mean differences between empirical and predicted scores were negligible (|SMD|<0.1). Conclusions: This study provides easy-to-apply algorithms to convert PROMIS-29 data to well-established SF-36 physical and mental component summary scores in a cardiovascular population. Applied to new data, the agreement between empirical and predicted SF-36 scores was high. However, for SF-36 mental component summary scores, considerably better predictions were found under the correlated (MCSc) than under the original factor model (MCS). Additionally, as a pertinent byproduct, our study confirmed construct validity of the relatively new PROMIS-29 health summary scores in cardiology patients. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Early clinical outcomes of Portico and Edwards Sapien 3 valve prosthesis in transcatheter aortic valve replacement: propensity-matched analysis.

Author

Primessnig, Uwe, Wiedenhofer, Julia M., Trippel, Tobias D., Loddenkemper, Carina M., Schrader, Helene, Brand, Anna, Spethmann, Sebastian, Stangl, Karl, Haghikia, Arash, Landmesser, Ulf, Boldt, Leif-Hendrik, Blaschke, Florian, Hindricks, Gerhard, Sündermann, Simon H., Grubitzsch, Herko, Falk, Volkmar, Dreger, Henryk, and Sherif, Mohammad

Published
2024
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18. Radiosurgery for ventricular tachycardia: preclinical and clinical evidence and study design for a German multi-center multi-platform feasibility trial (RAVENTA)

Author

Blanck, Oliver, Buergy, Daniel, Vens, Maren, Eidinger, Lina, Zaman, Adrian, Krug, David, Rudic, Boris, Boda-Heggemann, Judit, Giordano, Frank A., Boldt, Leif-Hendrik, Mehrhof, Felix, Budach, Volker, Schweikard, Achim, Olbrich, Denise, König, Inke R., Siebert, Frank-Andre, Vonthein, Reinhard, Dunst, Jürgen, and Bonnemeier, Hendrik

Published
2020
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20. Protocol of the Berlin Long-term Observation of Vascular Events (BeLOVE): a prospective cohort study with deep phenotyping and long-term follow up of cardiovascular high-risk patients

Author

Weber, Joachim E, primary, Ahmadi, Michael, additional, Boldt, Leif-Hendrik, additional, Eckardt, Kai-Uwe, additional, Edelmann, Frank, additional, Gerhardt, Holger, additional, Grittner, Ulrike, additional, Haubold, Kathrin, additional, Hübner, Norbert, additional, Kollmus-Heege, Jil, additional, Landmesser, Ulf, additional, Leistner, David M, additional, Mai, Knut, additional, Müller, Dominik N, additional, Nolte, Christian H, additional, Pieske, Burkert, additional, Piper, Sophie K, additional, Rattan, Simrit, additional, Rauch, Geraldine, additional, Schmidt, Sein, additional, Schmidt-Ott, Kai M, additional, Schönrath, Katharina, additional, Schulz-Menger, Jeanette, additional, Schweizerhof, Oliver, additional, Siegerink, Bob, additional, Spranger, Joachim, additional, Ramachandran, Vasan S, additional, Witzenrath, Martin, additional, Endres, Matthias, additional, and Pischon, Tobias, additional

Published
2023
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21. STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

Author

Grehn, Melanie, Mandija, Stefano, Miszczyk, Marcin, Krug, David, Tomasik, Bartłomiej, Stickney, Kristine E, Alcantara, Pino, Alongi, Filippo, Anselmino, Matteo, Aranda, Ricardo Salgado, Balgobind, Brian V, Boda-Heggemann, Judit, Boldt, Leif-Hendrik, Bottoni, Nicola, Cvek, Jakub, Elicin, Olgun, De Ferrari, Gaetano Maria, Hassink, Rutger J, Hazelaar, Colien, Hindricks, Gerhard, Hurkmans, Coen, Iotti, Cinzia, Jadczyk, Tomasz, Jiravsky, Otakar, Jumeau, Raphaël, Buus Kristiansen, Steen, Levis, Mario, López, Manuel Algara, Martí-Almor, Julio, Mehrhof, Felix, Møller, Ditte Sloth, Molon, Giulio, Ouss, Alexandre, Peichl, Petr, Plasek, Jiri, Postema, Pieter G, Quesada, Aurelio, Reichlin, Tobias Roman, Rordorf, Roberto, Rudic, Boris, Saguner, Ardan M, Ter Bekke, Rachel M A, Torrecilla, José López, Troost, Esther G C, Vitolo, Viviana, Andratschke, Nicolaus, Zeppenfeld, Katja, Blamek, Slawomir, Fast, Martin, de Panfilis, Ludovica, Blanck, Oliver, Pruvot, Etienne, and Verhoeff, Joost J C

Subjects
Cardiac arrhythmias, CATHETER ABLATION, Stereotactic body radiotherapy, Stereotactic arrhythmia radioablation, 610 Medicine & health, Ventricular tachycardia, GUIDELINES, STRUCTURAL HEART-DISEASE, DELINEATION, Physiology (medical), RADIATION-THERAPY, VENTRICULAR-TACHYCARDIA, EU Horizon 2020, BODY RADIOTHERAPY, Cardiology and Cardiovascular Medicine, Consortium, CONTOURING ATLAS
Abstract

The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions’ experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.

Published
2023
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22. Potential Usefulness and Clinical Relevance of Adding Left Atrial Strain to Left Atrial Volume Index in the Detection of Left Ventricular Diastolic Dysfunction

Author

Morris, Daniel A., Belyavskiy, Evgeny, Aravind-Kumar, Radhakrishnan, Kropf, Martin, Frydas, Athanasios, Braunauer, Kerstin, Marquez, Esteban, Krisper, Maximilian, Lindhorst, Ruhdja, Osmanoglou, Engin, Boldt, Leif-Hendrik, Blaschke, Florian, Haverkamp, Wilhelm, Tschöpe, Carsten, Edelmann, Frank, Pieske, Burkert, and Pieske-Kraigher, Elisabeth

Published
2018
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25. 2044: Radiosurgery for Ventricular Tachycardia (RAVENTA): Treatment Characteristics of a Multicenter Trial

Author

Krug, David, Zaman, Adrian, Grehn, Melanie, Boda-Heggemann, Judit, Rudic, Boris, Mehrhof, Felix, Boldt, Leif-Hendrik, Hohmann, Stephan, Merten, Roland, Rades, Dirk, Kirstein, Bettina, Corradini, Stefanie, Sinner, Moritz, Wittenstein, Olaf, Siebert, Frank-Andre, Bonnemeier, Hendrik, Dunst, Jürgen, Lyan, Evgeny, Tilz, Roland R., and Blanck, Oliver

Published
2024
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26. STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

Author

Computational Imaging, Cancer, Funding & Support, Team Medisch, Circulatory Health, Experimentele klinische fysica, MS Radiotherapie, Grehn, Melanie, Mandija, Stefano, Miszczyk, Marcin, Krug, David, Tomasik, Bartłomiej, Stickney, Kristine E, Alcantara, Pino, Alongi, Filippo, Anselmino, Matteo, Aranda, Ricardo Salgado, Balgobind, Brian V, Boda-Heggemann, Judit, Boldt, Leif-Hendrik, Bottoni, Nicola, Cvek, Jakub, Elicin, Olgun, De Ferrari, Gaetano Maria, Hassink, Rutger J, Hazelaar, Colien, Hindricks, Gerhard, Hurkmans, Coen, Iotti, Cinzia, Jadczyk, Tomasz, Jiravsky, Otakar, Jumeau, Raphaël, Buus Kristiansen, Steen, Levis, Mario, López, Manuel Algara, Martí-Almor, Julio, Mehrhof, Felix, Møller, Ditte Sloth, Molon, Giulio, Ouss, Alexandre, Peichl, Petr, Plasek, Jiri, Postema, Pieter G, Quesada, Aurelio, Reichlin, Tobias, Rordorf, Roberto, Rudic, Boris, Saguner, Ardan M, Ter Bekke, Rachel M A, Torrecilla, José López, Troost, Esther G C, Vitolo, Viviana, Andratschke, Nicolaus, Zeppenfeld, Katja, Blamek, Slawomir, Fast, Martin, de Panfilis, Ludovica, Blanck, Oliver, Pruvot, Etienne, Verhoeff, Joost J C, Computational Imaging, Cancer, Funding & Support, Team Medisch, Circulatory Health, Experimentele klinische fysica, MS Radiotherapie, Grehn, Melanie, Mandija, Stefano, Miszczyk, Marcin, Krug, David, Tomasik, Bartłomiej, Stickney, Kristine E, Alcantara, Pino, Alongi, Filippo, Anselmino, Matteo, Aranda, Ricardo Salgado, Balgobind, Brian V, Boda-Heggemann, Judit, Boldt, Leif-Hendrik, Bottoni, Nicola, Cvek, Jakub, Elicin, Olgun, De Ferrari, Gaetano Maria, Hassink, Rutger J, Hazelaar, Colien, Hindricks, Gerhard, Hurkmans, Coen, Iotti, Cinzia, Jadczyk, Tomasz, Jiravsky, Otakar, Jumeau, Raphaël, Buus Kristiansen, Steen, Levis, Mario, López, Manuel Algara, Martí-Almor, Julio, Mehrhof, Felix, Møller, Ditte Sloth, Molon, Giulio, Ouss, Alexandre, Peichl, Petr, Plasek, Jiri, Postema, Pieter G, Quesada, Aurelio, Reichlin, Tobias, Rordorf, Roberto, Rudic, Boris, Saguner, Ardan M, Ter Bekke, Rachel M A, Torrecilla, José López, Troost, Esther G C, Vitolo, Viviana, Andratschke, Nicolaus, Zeppenfeld, Katja, Blamek, Slawomir, Fast, Martin, de Panfilis, Ludovica, Blanck, Oliver, Pruvot, Etienne, and Verhoeff, Joost J C

Published
2023

27. STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

Author

Grehn, Melanie; https://orcid.org/0000-0002-6170-5122, Mandija, Stefano; https://orcid.org/0000-0002-4612-5509, Miszczyk, Marcin; https://orcid.org/0000-0002-4375-0827, Krug, David; https://orcid.org/0000-0001-8811-5416, Tomasik, Bartłomiej; https://orcid.org/0000-0001-5648-345X, Stickney, Kristine E, Alcantara, Pino; https://orcid.org/0000-0001-5744-9480, Alongi, Filippo, Anselmino, Matteo; https://orcid.org/0000-0002-6311-4270, Aranda, Ricardo Salgado; https://orcid.org/0000-0002-2627-8436, Balgobind, Brian V, Boda-Heggemann, Judit, Boldt, Leif-Hendrik, Bottoni, Nicola, Cvek, Jakub; https://orcid.org/0000-0003-1579-1792, Elicin, Olgun; https://orcid.org/0000-0002-6996-0646, De Ferrari, Gaetano Maria; https://orcid.org/0000-0003-4940-0876, Hassink, Rutger J; https://orcid.org/0000-0003-0237-7867, Hazelaar, Colien, Hindricks, Gerhard; https://orcid.org/0000-0002-0132-0773, Hurkmans, Coen; https://orcid.org/0000-0003-2268-0492, Iotti, Cinzia; https://orcid.org/0000-0001-9686-7298, Jadczyk, Tomasz; https://orcid.org/0000-0002-7955-9100, Jiravsky, Otakar; https://orcid.org/0000-0001-9334-5734, Jumeau, Raphaël; https://orcid.org/0000-0002-0098-8835, Kristiansen, Steen Buus, Levis, Mario; https://orcid.org/0000-0002-7668-3296, López, Manuel Algara; https://orcid.org/0000-0002-0500-9202, Martí-Almor, Julio; https://orcid.org/0000-0001-9927-1190, Mehrhof, Felix; https://orcid.org/0000-0003-0553-4290, et al, Grehn, Melanie; https://orcid.org/0000-0002-6170-5122, Mandija, Stefano; https://orcid.org/0000-0002-4612-5509, Miszczyk, Marcin; https://orcid.org/0000-0002-4375-0827, Krug, David; https://orcid.org/0000-0001-8811-5416, Tomasik, Bartłomiej; https://orcid.org/0000-0001-5648-345X, Stickney, Kristine E, Alcantara, Pino; https://orcid.org/0000-0001-5744-9480, Alongi, Filippo, Anselmino, Matteo; https://orcid.org/0000-0002-6311-4270, Aranda, Ricardo Salgado; https://orcid.org/0000-0002-2627-8436, Balgobind, Brian V, Boda-Heggemann, Judit, Boldt, Leif-Hendrik, Bottoni, Nicola, Cvek, Jakub; https://orcid.org/0000-0003-1579-1792, Elicin, Olgun; https://orcid.org/0000-0002-6996-0646, De Ferrari, Gaetano Maria; https://orcid.org/0000-0003-4940-0876, Hassink, Rutger J; https://orcid.org/0000-0003-0237-7867, Hazelaar, Colien, Hindricks, Gerhard; https://orcid.org/0000-0002-0132-0773, Hurkmans, Coen; https://orcid.org/0000-0003-2268-0492, Iotti, Cinzia; https://orcid.org/0000-0001-9686-7298, Jadczyk, Tomasz; https://orcid.org/0000-0002-7955-9100, Jiravsky, Otakar; https://orcid.org/0000-0001-9334-5734, Jumeau, Raphaël; https://orcid.org/0000-0002-0098-8835, Kristiansen, Steen Buus, Levis, Mario; https://orcid.org/0000-0002-7668-3296, López, Manuel Algara; https://orcid.org/0000-0002-0500-9202, Martí-Almor, Julio; https://orcid.org/0000-0001-9927-1190, Mehrhof, Felix; https://orcid.org/0000-0003-0553-4290, and et al

Abstract

The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions' experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.

Published
2023

28. Quality assurance process within the RAdiosurgery for VENtricular TAchycardia (RAVENTA) trial for the fusion of electroanatomical mapping and radiotherapy planning imaging data in cardiac radioablation

Author

Mayinger, Michael, Boda-Heggemann, Judit, Mehrhof, Felix, Krug, David, Hohmann, Stephan, Xie, Jingyang, Ehrbar, Stefanie, Kovacs, Boldizsar, Merten, Roland, Grehn, Melanie, Zaman, Adrian, Fleckenstein, Jens, Kaestner, Lena, Buergy, Daniel, Rudic, Boris, Kluge, Anne, Boldt, Leif-Hendrik, Dunst, Jürgen, Bonnemeier, Hendrik, Saguner, Ardan M, Andratschke, Nicolaus, Blanck, Oliver, Schweikard, Achim, Mayinger, Michael, Boda-Heggemann, Judit, Mehrhof, Felix, Krug, David, Hohmann, Stephan, Xie, Jingyang, Ehrbar, Stefanie, Kovacs, Boldizsar, Merten, Roland, Grehn, Melanie, Zaman, Adrian, Fleckenstein, Jens, Kaestner, Lena, Buergy, Daniel, Rudic, Boris, Kluge, Anne, Boldt, Leif-Hendrik, Dunst, Jürgen, Bonnemeier, Hendrik, Saguner, Ardan M, Andratschke, Nicolaus, Blanck, Oliver, and Schweikard, Achim

Abstract

A novel quality assurance process for electroanatomical mapping (EAM)-to-radiotherapy planning imaging (RTPI) target transport was assessed within the multi-center multi-platform framework of the RAdiosurgery for VENtricular TAchycardia (RAVENTA) trial. A stand-alone software (CARDIO-RT) was developed to enable platform independent registration of EAM and RTPI of the left ventricle (LV), based on pre-generated radiotherapy contours (RTC). LV-RTC were automatically segmented into the American-Heart-Association 17-segment-model and a manual 3D-3D method based on EAM 3D-geometry data and a semi-automated 2D-3D method based on EAM screenshot projections were developed. The quality of substrate transfer was evaluated in five clinical cases and the structural analyses showed substantial differences between manual target transfer and target transport using CARDIO-RT.

Published
2023

29. Evaluating Real-World Clinical Outcomes in Atrial Fibrillation Patients Receiving the WATCHMAN Left Atrial Appendage Closure Technology: Final 2-Year Outcome Data of the EWOLUTION Trial Focusing on History of Stroke and Hemorrhage

Author

Boersma, Lucas V., Ince, Hueseyin, Kische, Stephan, Pokushalov, Evgeny, Schmitz, Thomas, Schmidt, Boris, Gori, Tommaso, Meincke, Felix, Protopopov, Alexey Vladimir, Betts, Timothy, Mazzone, Patrizio, Foley, David, Grygier, Marek, Sievert, Horst, De Potter, Tom, Vireca, Elisa, Stein, Kenneth, Bergmann, Martin W., Al Nooryani, Arif, Fiedler, Thomas, Senatore, Gaetano, Brigadeau, François, Defaye, Pascal, Teiger, Emmanuel, Bonnet, Jean-Louis, Wald, Christof, Szili-Torok, Tamas, Tschishow, Wladimir, Crossland, David, Vahanian, Alec, Cruz-Gonzalez, Ignacio, Thambo, Jean-Benoit, Al Smadi, Faisal, Mudra, Harald, Molitoris, Robin, Folkeringa, Richard, Stevenhagen, Yorick, Gras, Daniel, Tamburino, Corrado, Molon, Giulio, Spence, Mark, Infante Oliveira, Eduardo, Merkulov, Evgeny, Sukiennik, Adam, Wong, Tom, Busch, Mathias, Boldt, Leif-Hendrik, Nickenig, Georg, and Neef, Martin

Published
2019
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30. Quality assurance process within the RAdiosurgery for VENtricular TAchycardia (RAVENTA) trial for the fusion of electroanatomical mapping and radiotherapy planning imaging data in cardiac radioablation

Author

Mayinger, Michael, primary, Boda-Heggemann, Judit, additional, Mehrhof, Felix, additional, Krug, David, additional, Hohmann, Stephan, additional, Xie, Jingyang, additional, Ehrbar, Stefanie, additional, Kovacs, Boldizsar, additional, Merten, Roland, additional, Grehn, Melanie, additional, Zaman, Adrian, additional, Fleckenstein, Jens, additional, Kaestner, Lena, additional, Buergy, Daniel, additional, Rudic, Boris, additional, Kluge, Anne, additional, Boldt, Leif-Hendrik, additional, Dunst, Jürgen, additional, Bonnemeier, Hendrik, additional, Saguner, Ardan M., additional, Andratschke, Nicolaus, additional, Blanck, Oliver, additional, and Schweikard, Achim, additional

Published
2023
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34. Treatment Planning for Cardiac Radioablation: Multicenter Multiplatform Benchmarking for the RAdiosurgery for VENtricular TAchycardia (RAVENTA) Trial

Author

Kluge, Anne, primary, Ehrbar, Stefanie, additional, Grehn, Melanie, additional, Fleckenstein, Jens, additional, Baus, Wolfgang W., additional, Siebert, Frank-Andre, additional, Schweikard, Achim, additional, Andratschke, Nicolaus, additional, Mayinger, Michael C., additional, Boda-Heggemann, Judit, additional, Buergy, Daniel, additional, Celik, Eren, additional, Krug, David, additional, Kovacs, Boldizsar, additional, Saguner, Ardan M., additional, Rudic, Boris, additional, Bergengruen, Paula, additional, Boldt, Leif-Hendrik, additional, Stauber, Annina, additional, Zaman, Adrian, additional, Bonnemeier, Hendrik, additional, Dunst, Jürgen, additional, Budach, Volker, additional, Blanck, Oliver, additional, and Mehrhof, Felix, additional

Published
2022
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44. Treatment Planning for Cardiac Radioablation: Multicenter Multiplatform Benchmarking for the RAdiosurgery for VENtricular TAchycardia (RAVENTA) Trial

Author

Kluge, Anne, Ehrbar, Stefanie, Grehn, Melanie, Fleckenstein, Jens, Baus, Wolfgang W., Siebert, Frank-Andre, Schweikard, Achim, Andratschke, Nicolaus, Mayinger, Michael C., Boda-Heggemann, Judit, Buergy, Daniel, Celik, Eren, Krug, David, Kovacs, Boldizsar, Saguner, Ardan M., Rudic, Boris, Bergengruen, Paula, Boldt, Leif-Hendrik, Stauber, Annina, Zaman, Adrian, Bonnemeier, Hendrik, Dunst, Jurgen, Budach, Volker, Blanck, Oliver, Mehrhof, Felix, Kluge, Anne, Ehrbar, Stefanie, Grehn, Melanie, Fleckenstein, Jens, Baus, Wolfgang W., Siebert, Frank-Andre, Schweikard, Achim, Andratschke, Nicolaus, Mayinger, Michael C., Boda-Heggemann, Judit, Buergy, Daniel, Celik, Eren, Krug, David, Kovacs, Boldizsar, Saguner, Ardan M., Rudic, Boris, Bergengruen, Paula, Boldt, Leif-Hendrik, Stauber, Annina, Zaman, Adrian, Bonnemeier, Hendrik, Dunst, Jurgen, Budach, Volker, Blanck, Oliver, and Mehrhof, Felix

Abstract

Purpose: Cardiac radioablation is a novel treatment option for patients with refractory ventricular tachycardia unsuitable for catheter ablation. The quality of treatment planning depends on dose specifications, platform capabilities, and experience of the treating staff. To harmonize the treatment planning, benchmarking of this process is necessary for multicenter clinical studies such as the RAdiosurgery for VENtricular TAchycardia trial. Methods and Materials: Planning computed tomography data and consensus structures from 3 patients were sent to 5 academic centers for independent plan development using a variety of platforms and techniques with the RAdiosurgery for VENtricular TAchycardia study protocol serving as guideline. Three-dimensional dose distributions and treatment plan details were collected and analyzed. In addition, an objective relative plan quality ranking system for ventricular tachycardia treatments was established. Results: For each case, 3 coplanar volumetric modulated arc (VMAT) plans for C-arm linear accelerators (LINAC) and 3 non-coplanar treatment plans for robotic arm LINAC were generated. All plans were suitable for clinical applications with minor deviations from study guidelines in most centers. Eleven of 18 treatment plans showed maximal one minor deviation each for target and cardiac substructures. However, dose-volume histograms showed substantial differences: in one case, the planning target volume >= 30 Gy ranged from 0.0% to 79.9% and the ramus interventricularis anterior V-14Gy ranged from 4.0% to 45.4%. Overall, the VMAT plans had steeper dose gradients in the high-dose region, while the plans for the robotic arm LINAC had smaller low-dose regions. Thereby, VMAT plans required only about half as many monitor units, resulting in shorter delivery times, possibly an important factor in treatment outcome. Conclusions: Cardiac radioablation is feasible with robotic arm and C-arm LINAC systems with comparable plan quality. Although c

Published
2022

46. Normal range and usefulness of right ventricular systolic strain to detect subtle right ventricular systolic abnormalities in patients with heart failure: a multicentre study

Author

Morris, Daniel A., Krisper, Maximilian, Nakatani, Satoshi, Köhncke, Clemens, Otsuji, Yutaka, Belyavskiy, Evgeny, Radha Krishnan, Aravind K., Kropf, Martin, Osmanoglou, Engin, Boldt, Leif-Hendrik, Blaschke, Florian, Edelmann, Frank, Haverkamp, Wilhelm, Tschöpe, Carsten, Pieske-Kraigher, Elisabeth, Pieske, Burkert, and Takeuchi, Masaaki

Published
2017
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49. AB-482901-005 FEASIBILITY OF RADIOSURGERY FOR VENTRICULAR TACHYCARDIA – PRIMARY ENDPOINT ANALYSIS FOR THE GERMAN MULTICENTER MULTIPLATFORM TRIAL RAVENTA

Author

Zaman, Adrian, Krug, David, Grehn, Melanie, Boda-Heggemann, Judit, Rudic, Boris, Mehrhof, Felix, Boldt, Leif-Hendrik, Hohmann, Stephan, Merten, Roland, Rades, Dirk, Kirstein, Bettina, Corradini, Stefanie, Sinner, Moritz F., Buergy, Daniel, Wittenstein, Olaf, Siebert, Frank-André, Schweikard, Achim, Bonnemeier, Henrik, Hindricks, Gerhard, Dunst, Jürgen, Lyan, Evgeny, Tilz, Roland R., and Blanck, Oliver

Published
2024
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50. 321: Semi-automated reproducible target transfer for STAR – Cross-validation within the RAVENTA trial

Author

Hohmann, Stephan, Xie, Jingyang, Eckl, Miriam, Grehn, Melanie, Karfoul, Nizar, Janorschke, Christian, Roland, Merten, Rudic, Boris, Buergy, Daniel, Lyan, Evgeny, Krug, David, Mehrhof, Felix, Boldt, Leif-Hendrik, Corradini, Stefanie, Fanslau, Hannah, Kaestner, Lena, Zaman, Adrian, Giordano, Frank A., Duncker, David, Dunst, Juergen, Tilz, Roland R., Schweikard, Achim, Blanck, Oliver, and Boda-Heggemann, Judit

Published
2024
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