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Your search keyword '"Bolouri, Mohammad-Reza"' showing total 15 results
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15 results on '"Bolouri, Mohammad-Reza"'

1. Catalase-gold nanoaggregates manipulate the tumor microenvironment and enhance the effect of low-dose radiation therapy by reducing hypoxia

Author

Najafi, Alireza, Keykhaee, Maryam, Kazemi, Mohammad Hossein, Karimi, Mohammad Yahya, Khorramdelazad, Hossein, Aghamohamadi, Nazanin, Bolouri, Mohammad-Reza, Ghaffari-Nazari, Haniyeh, Mirsharif, Ensie Sadat, Karimi, Milad, Dehghan Manshadi, Hamid Reza, Mahdavi, Seied Rabi, Safari, Elahe, Jalali, Seyed Amir, Falak, Reza, and Khoobi, Mehdi

Published
2023
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6. Introduction of an efficient method for placenta decellularization with high potential to preserve ultrastructure and support cell attachment

Author

Sajed, Roya, primary, Zarnani, Amir‐Hassan, additional, Madjd, Zahra, additional, Arefi, Soheila, additional, Bolouri, Mohammad Reza, additional, Vafaei, Sedigheh, additional, Samadikuchaksaraei, Ali, additional, Gholipourmalekabadi, Mazaher, additional, Haghighipour, Nooshin, additional, and Ghods, Roya, additional

Published
2022
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8. Oridonin Could Inhibit Inflammation and T-cell Immunoglobulin and Mucin-3/Galectin-9 (TIM-3/Gal-9) Autocrine Loop in the Acute Myeloid Leukemia Cell Line (U937) as Compared to Doxorubicin

Author

Nasri, Farzad, primary, Sadeghi, Fatemeh, additional, Behranvand, Nafiseh, additional, Samei, Azam, additional, Bolouri, Mohammad Reza, additional, Azari, Tahereh, additional, Abdollahi, Elaheh, additional, Ghazizadeh, Foad, additional, Motevalian, Manijeh, additional, and Mohammad Hassan, Zuhair, additional

Published
2020
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15. Competitive Effect of Overexpressed C-terminal of Snail-1 (CSnail) in Control of the Growth and Metastasis of Melanoma Cells.

Author

Rostami SP, Dehkordi NM, Asgari Y, Bolouri MR, Shayanfar N, Falak R, and Kardar GA

Subjects
Animals, Mice, Humans, Snail Family Transcription Factors genetics, Snail Family Transcription Factors pharmacology, Cell Line, Tumor, Epithelial-Mesenchymal Transition, Cell Movement, Gene Expression Regulation, Neoplastic, Neoplasm Invasiveness, Neoplasm Metastasis, Melanoma genetics
Abstract

Background: Epithelial-to-mesenchymal transition (EMT) plays a role in the invasion and metastasis of cancer cells. During this phenomenon, Snail can promote tumor progression by upregulating mesenchymal factors and downregulating the expression of pro-apoptotic proteins., Objective: Therefore, interventions on the expression rate of Snails may show beneficial therapeutic applications., Methods: In this study, the C-terminal region of Snail1, capable of binding to E-box genomic sequences, was subcloned into the pAAV-IRES-EGFP backbone to make complete AAV-CSnail viral particles. B16F10 as a metastatic melanoma cell line, with a null expression of wild type TP53 was transduced by AAV-CSnail. Moreover, the transduced cells were analyzed for in vitro expression of apoptosis, migration, and EMT-related genes, and in vivo inhibition of metastasis., Results: In more than 80% of the AAV-CSnail transduced cells, the CSnail gene expression competitively reduced the wild-type Snail functionality and consequently lowered the mRNA expression level of EMT-related genes. Furthermore, the transcription level of cell cycle inhibitory factor p21 and pro-apoptotic factors were promoted. The scratch test showed a decrease in the migration ability of AAV-CSnail transduced group compared to control. Finally, metastasis of cancer cells to lung tissue in the AAV-CSnail-treated B16F10 melanoma mouse model was significantly reduced, pointing out to prevention of EMT by the competitive inhibitory effect of CSnail on Snail1 and increased apoptosis of B16F10 cells., Conclusion: The capability of this successful competition in reducing the growth, invasion, and metastasis of melanoma cells indicates that gene therapy is a promising strategy for the control of the growth and metastasis of cancer cells., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2024
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