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1. Author Correction: Comparison of the management of Helicobacter pylori infection between the older and younger European populations

Author

Jonaitis, Paulius, Nyssen, Olga P., Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez-Aísa, Ángeles, Tepes, Bojan, Castro-Fernandez, Manuel, Pabón-Carrasco, Manuel, Keco-Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez-Domínguez, Samuel J., Almajano, Enrique Alfaro, Rodrigo, Luis, Vologzanina, Ludmila, Brglez Jurecic, Natasa, Denkovski, Maja, Bujanda, Luis, Mahmudov, Umud, Leja, Mārcis, Lerang, Frode, Babayeva, Gülüstan, Bordin, Dmitry S., Gasbarrini, Antonio, Kupcinskas, Juozas, Gridnyev, Oleksiy, Rokkas, Theodore, Marcos-Pinto, Ricardo, Phull, Perminder S., Smith, Sinead M., Tonkić, Ante, Boltin, Doron, Buzás, György Miklós, Šembera, Štěpán, Şimşek, Halis, Matysiak-Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano-Català, Anna, Moreira, Leticia, Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., and Jonaitis, Laimas

Published
2023
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2. Comparison of the management of Helicobacter pylori infection between the older and younger European populations

Author

Jonaitis, Paulius, Nyssen, Olga P., Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez-Aísa, Ángeles, Tepes, Bojan, Castro-Fernandez, Manuel, Pabón-Carrasco, Manuel, Keco-Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez-Domínguez, Samuel J., Almajano, Enrique Alfaro, Rodrigo, Luis, Vologzanina, Ludmila, Brglez Jurecic, Natasa, Denkovski, Maja, Bujanda, Luis, Mahmudov, Umud, Leja, Mārcis, Lerang, Frode, Babayeva, Gülüstan, Bordin, Dmitry S., Gasbarrini, Antonio, Kupcinskas, Juozas, Gridnyev, Oleksiy, Rokkas, Theodore, Marcos-Pinto, Ricardo, Phull, Perminder S., Smith, Sinead M., Tonkić, Ante, Boltin, Doron, Buzás, György Miklós, Šembera, Štěpán, Şimşek, Halis, Matysiak-Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano-Català, Anna, Moreira, Leticia, Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., and Jonaitis, Laimas

Published
2023
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4. Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)

Author

Fiorinni, Giulia, Saracino, Ilaria Maria, Carrasco, Manuel Pabon, Huerga, Alma Keco, Almajano, Enrique Alfaro, Martinez Dominguez, Samuel Jesus, Galan, Horacio Alonso, Velayos, Benito, Sadornil, Carmen Dueñas, Botargues Bote, Jose Maria, Gonzalez-Cordero, Pedro Luis, Areia, Miguel, Gomez Rodriguez, Blas Jose, Pellicano, Rinaldo, Nuñez, Óscar, Franceschi, Francesco, Alekseenko, Sergey, Perona, Monica, Abdulkhakov, Rustam, Dominguez-Cajal, Manuel, Notari, Pedro Almela, Camarero, Judith Gomez, Moreno, Manuel Jimenez, Algaba, Alicia, Bermejo, Fernando, Tejada, Javier Tejedor, Susanibar, Elida Oblitas, Boltin, Doron, Georgopoulos, Sotirios, OMorain, Colm, Qasim, Asghar, Beales, Ian, Bakulina, Natalia, Fadeenko, Galina, Malfertheiner, Peter, Rosania, Rosa, Ilchishina, Tatiana, Bogomolov, Pavel, Bakulin, Igor, Zaytsev, Oleg, Gravina, Antonietta Gerarda, Romano, Marco, Di Leo, Alfredo, Losurdo, Giuseppe, Grigorieva, Ludmila, Guillena, Pedro Delgado, Marusic, Marinko, Jurcic, Dragan, Dekhnich, Natalia Nikolaevna, Iyo, Eduardo, de la Peña Negro, Luisa Carmen, Baryshnikova, Natalia, Bakanova, Natalia, Simsek, Halis, Simsek, Cem, Gridnyev, Oleksiy, Fernandez-Bermejo, Miguel, Angueira, Teresa, Ruiz-Zorrilla Lopez, Rafael, Gomez, Barbara, Kovacheva-Slavova, Mila, Lahat, Adi, Alcedo, Javier, Campillo, Ana, Belousova, Liya Nikolaevna, Villarroya, Ramon Pajares, Ljubicic, Neven, Nikolic, Marko, González-Santiago, Jesús M., Santamaría, Diego Burgos, Pakhomova, Anna, Sekulic-Spasic, Izabela, Ghisa, Matteo, Farinati, Fabio, Sagdati, Sabir Irfan, Panic, Nikola, Heluwaert, Frederic, Amorena, Edurne, Moreira, Leticia, Esparrach, Gloria Fernandez, Plotnikova, Ekaterina Yuryevna, Kukla, Michal, Kamburov, Victor, Lamuela Calvo, Luis Javier, Rankovic, Ivan, Lavín, Antonio Cuadrado, Lazaro, Yolanda Arguedas, Carrera Agnieszka Dobrowolska, Victor Gonzalez, Eder, Piotr, Kononova, Alla, Nyssen, Olga P., Vaira, Dino, Pérez Aísa, Ángeles, Rodrigo, Luis, Castro-Fernandez, Manuel, Jonaitis, Laimas, Tepes, Bojan, Vologzhanina, Liudmila, Caldas, María, Lanas, Angel, Lucendo, Alfredo J., Bujanda, Luis, Ortuño, Juan, Barrio, Jesús, Huguet, Jose M., Voynovan, Irina, Lasala, Jorge Perez, Sarsenbaeva, Aiman Silkanovna, Fernandez-Salazar, Luis, Molina-Infante, Javier, Jurecic, Natasa Brglez, Gasbarrini, Antonio, Kupčinskas, Juozas, Bordin, Dmitry, Marcos-Pinto, Ricardo, Lerang, Frode, Leja, Marcis, Buzas, Gyorgy M., Niv, Yaron, Rokkas, Theodore, Phull, Perminder, Smith, Sinead, Shvets, Oleg, Venerito, Marino, Milivojevic, Vladimir, Simsek, Ilkay, Lamy, Vincent, Bytzer, Peter, Boyanova, Lyudmila, Kunovský, Lumír, Beglinger, Christoph, Doulberis, Michael, Marlicz, Wojciech, Goldis, Adrian, Tonkić, Ante, Capelle, Lisette, Puig, Ignasi, Megraud, Francis, Morain, Colm O’, and Gisbert, Javier P.

Published
2022
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10. Comparison of Four Tests for the Diagnosis of Helicobacter pylori Infection.

Author

Charach, Lior, Perets, Tsachi Tsadok, Gingold-Belfer, Rachel, Huta, Yair, Ashorov, Olga, Levi, Zohar, Dickman, Ram, and Boltin, Doron

Subjects
HELICOBACTER disease diagnosis, FECES, BACTERIAL antigens, RESEARCH evaluation, LOGISTIC regression analysis, CHEMILUMINESCENCE assay, HOST-bacteria relationships, MULTIVARIATE analysis, DESCRIPTIVE statistics, CLINICAL pathology, UREASE, INDIGESTION, LONGITUDINAL method, ATROPHY, METAPLASIA, ODDS ratio, GASTROSCOPY, STATISTICS, IMMUNOASSAY, STAINS & staining (Microscopy), INFLAMMATION, DATA analysis software, BREATH tests, HISTOLOGY, SENSITIVITY & specificity (Statistics), GASTROESOPHAGEAL reflux
Abstract

Background: Due to lower operational costs, health maintenance organizations (HMOs) may prioritize Helicobacter pylori stool antigen testing (HpStAg) for the non-invasive diagnosis of H. pylori infection over 13C-urea breath tests (13C-UBTs). The aim of our study was to compare the accuracy of the diagnostic tests for H. pylori. Methods: We performed histology, rapid urease test (RUT), 13C-UBT and HpStAg on consecutive patients referred for gastroscopy. Monoclonal stool antigen test was performed using the LIAISON Meridian chemiluminescent immunoassay. Histology was examined with hematoxylin and eosin, and additional stains were performed at the pathologist's discretion. For the assessment of 13C-UBT, we compared concordant histology and RUT. HpStAg was compared to the concordant results of two of the three remaining tests. Results: 103 patients were included (36 males (35.0%), age 50.1 ± 18.4 years). The indication for gastroscopy was dyspepsia in 63 (61.2%). Agreement between RUT and histology was 95.9%. For 13C-UBT and HpStAg, respectively, H. pylori positivity was 30% (30/100) and 27.16% (22/81); sensitivity was 97% and 70%; specificity was 100% and 94.4%; accuracy was 98% and 86%; positive predictive value (PPV) was 100% and 86.4%; negative predictive value (NPV) was 93% and 86%. No demographic, clinical, or endoscopic predictors of HpStAg accuracy were identified using logistic regression. Conclusions: 13C-UBT performs better than HpStAg at our institution. When interpreting results, clinicians should consider test limitations. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Effectiveness of Helicobacter pylori Treatments According to Antibiotic Resistance

Author

Bujanda, Luis, primary, Nyssen, Olga P., additional, Ramos, June, additional, Bordin, Dmitry S., additional, Tepes, Bojan, additional, Perez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Castro-Fernandez, Manuel, additional, Lerang, Frode, additional, Leja, Mārcis, additional, Rodrigo, Luis, additional, Rokkas, Theodore, additional, Kupcinskas, Juozas, additional, Jonaitis, Laimas, additional, Shvets, Oleg, additional, Gasbarrini, Antonio, additional, Simsek, Halis, additional, Phull, Perminder S., additional, Buzás, György Miklós, additional, Machado, Jose C., additional, Boltin, Doron, additional, Boyanova, Lyudmila, additional, Tonkić, Ante, additional, Marlicz, Wojciech, additional, Venerito, Marino, additional, Vologzanina, Ludmila, additional, Fadieienko, Galina D., additional, Fiorini, Giulia, additional, Resina, Elena, additional, Muñoz, Raquel, additional, Cano-Català, Anna, additional, Puig, Ignasi, additional, García-Morales, Natalia, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Megraud, Francis, additional, Morain, Colm O., additional, Montes, Milagrosa, additional, and Gisbert, Javier P., additional

Published
2024
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13. Role of compliance in Helicobacter pylorieradication treatment: Results of the European Registry on H. pylorimanagement

Author

Huguet, Jose M., Ferrer‐Barceló, Luis, Suárez, Patrícia, Barcelo‐Cerda, Susana, Sempere, Javier, Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez‐Aísa, Ángeles, Jonaitis, Laimas, Tepes, Bojan, Castro‐Fernandez, M., Pabón‐Carrasco, Manuel, Keco‐Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez‐Domínguez, Samuel J., Alfaro Almajano, Enrique, Rodrigo, Luis, Vologzanina, Ludmila, Bordin, Dmitry S., Gasbarrini, Antonio, Babayeva, Gülüstan, Lerang, Frode, Leja, Mārcis, Kupčinskas, Juozas, Rokkas, Theodore, Marcos‐Pinto, Ricardo, Meštrović, Antonio, Gridnyev, Oleksiy, Phull, Perminder S., Smith, Sinead M., Boltin, Doron, Buzás, György Miklós, Kral, Jan, Şimşek, Halis, Matysiak‐Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano‐Català, Anna, Moreira, Leticia, Nyssen, Olga P., Mégraud, Francis, O’Morain, Colm, and Gisbert, Javier P.

Abstract

Adherence to Helicobacter pylori (H. pylori)eradication treatment is a cornerstone for achieving adequate treatment efficacy. To determine which factors influence compliance with treatment. A systematic prospective non‐interventional registry (Hp‐EuReg) of the clinical practice of European gastroenterologists. Compliance was considered adequate if ≥90% drug intake. Data were collected until September 2021 using the AEG‐REDCap e‐CRF and were subjected to quality control. Modified intention‐to‐treat analyses were performed. Multivariate analysis carried out the factors associated with the effectiveness of treatment and compliance. Compliance was inadequate in 646 (1.7%) of 38,698 patients. The non‐compliance rate was higher in patients prescribed longer regimens (10‐, 14‐days) and rescue treatments, patients with uninvestigated dyspepsia/functional dyspepsia, and patients reporting adverse effects. Prevalence of non‐adherence was lower for first‐line treatment than for rescue treatment (1.5% vs. 2.2%; p< 0.001). Differences in non‐adherence in the three most frequent first‐line treatments were shown: 1.1% with proton pump inhibitor + clarithromycin + amoxicillin; 2.3% with proton pump inhibitor clarithromycin amoxicillin metronidazole; and 1.8% with bismuth quadruple therapy. These treatments were significantly more effective in compliant than in non‐compliant patients: 86% versus 44%, 90% versus 71%, and 93% versus 64%, respectively (p< 0.001). In the multivariate analysis, the variable most significantly associated with higher effectiveness was adequate compliance (odds ratio, 6.3 [95%CI, 5.2–7.7]; p< 0.001). Compliance with Helicobacter pylorieradication treatment is very good. Factors associated with poor compliance include uninvestigated/functional dyspepsia, rescue‐treatment, prolonged treatment regimens, the presence of adverse events, and the use of non‐bismuth sequential and concomitant treatment. Adequate treatment compliance was the variable most closely associated with successful eradication.

Published
2024
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16. Predictors of poor outcome following liver biopsy for the investigation of new hepatic space occupying lesion/s

Author

Gingold-Belfer, Rachel, primary, Shinhar, Nadav, additional, Bachar, Gil N., additional, Issa, Nidal, additional, Boltin, Doron, additional, Sharon, Eran, additional, Shohat, Tzippy, additional, Sapoznikov, Boris, additional, Swartz, Ariel, additional, Peleg, Noam, additional, Konikoff, Tom, additional, and Schmilovitz-Weiss, Hemda, additional

Published
2023
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19. 131 - PAUTAS Y EFECTIVIDAD DE LAS TERAPIAS CUÁDRUPLES CON BISMUTO EN EUROPA: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Calvet, Xavier, primary, Gené, Emili, additional, Olmedo, Llum, additional, Bordin, Dmitry, additional, García-Morales, Natalia, additional, Hernández, Luis, additional, Gridnyev, Oleksiy, additional, Kupinskas, Juozas, additional, Gasbarrini, Antonio, additional, Boltin, Doron, additional, Babayeva, Gulustan, additional, Pinto, Ricardo Marcos, additional, Tepes, Bojan, additional, Buzas, Gyorgy M, additional, Papp, Veronika, additional, Simsek, Halis, additional, Cano-Català, Anna, additional, Moreira, Leticia, additional, Puig, Ignasi, additional, Nyssen, Olga P., additional, Mégraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
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20. 129 - EFECTIVIDAD DE LOS TRATAMIENTOS FRENTE A HELICOBACTER PYLORI EN FUNCIÓN DE LAS RESISTENCIAS ANTIBIÓTICAS: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Bujanda, Luis, primary, Nyssen, Olga P., additional, Ramos, June, additional, Bordin, Dmitry S., additional, Tepes, Bojan, additional, Pérez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Castro-Fernández, Manuel, additional, Lerang, Frode, additional, Leja, Marcis, additional, Rodrigo, Luis, additional, Rokkas, Theodore, additional, Kupcinskas, Juozas, additional, Jonaitis, Laimas, additional, Shvets, Oleg, additional, Gasbarrini, Antonio, additional, Simsek, Halis, additional, Phull, Perminder S, additional, Buzás, Gyorgiy Miklós, additional, Machado, Jose C., additional, Boltin, Doron, additional, Boyanova, Lyudmila, additional, Tonkic, Ante, additional, Marlicz, Wojciech, additional, Venerito, Marino, additional, Vologzanina, Ludmila, additional, Fadieienko, Galina D, additional, Fiorini, Giulia, additional, Resina, Elena, additional, Muñoz, Raquel, additional, Cano-Catalá, Anna, additional, Puig, Ignasi, additional, García-Morales, Natalia, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Megraud, Francis, additional, Morain, Colm O, additional, and Gisbert, Javier P., additional

Published
2023
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24. PAPEL DEL USO DE PROBIÓTICOS EN LA EFECTIVIDAD DE LOS TRATAMIENTOS FRENTE A HELICOBACTER PYLORI: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Casas, Diego, primary, Alcedo, Javier, additional, Lafuente, Miguel, additional, López, F. Javier, additional, Pérez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Saracino, Ilaria Maria, additional, Tepes, Bojan, additional, Jonaitis, Laimas, additional, Castro-Fernández, Manuel, additional, Carrasco, Manuel Pabón, additional, Huerga, Alma Keco-, additional, Voynovan, Irina, additional, Bujanda, Luis, additional, Lucendo, Alfredo J., additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Phull, Perminder S., additional, Rodrigo, Luis, additional, Lanas, Angel, additional, Martínez-Domínguez, Samuel J., additional, Alfaro, Enrique, additional, Fadieienko, Galina D, additional, Huguet, José M., additional, Bordin, Dmitry S., additional, Gasbarrini, Antonio, additional, Kupcinskas, Juozas, additional, Babayeva, Gülüstan, additional, Gridnyev, Oleksiy, additional, Leja, Mrcis, additional, Rokkas, Theodore, additional, Marcos-Pinto, Ricardo, additional, Lerang, Frode, additional, Boltin, Doron, additional, Papp, Veronika, additional, Tonki, Ante, additional, Smith, Sinead M., additional, Simsek, Halis, additional, Venerito, Marino, additional, Boyanova, Lyudmila, additional, Milivojevic, Vladimir, additional, Kunovsky, Lumir, additional, Matysiak-Budnik, Tamara, additional, Marlicz, Wojciech, additional, Doulberis, Michael, additional, Cano-Català, Anna, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Nyssen, Olga P., additional, Megraud, Francis, additional, Morain, Colm O., additional, and Gisbert, Javier P., additional

Published
2023
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25. 135 - TENDENCIAS DE PRESCRIPCIÓN DE TRATAMIENTOS ERRADICADORES Y DE SU EFECTIVIDAD EN PACIENTES NAÏVE A LO LARGO DE 10 AÑOS (2013-2022) EN EUROPA: DATOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Nyssen, Olga P., primary, Jonaitis, Laimas, additional, Pérez-Aísa, Ángeles, additional, Vaira, Dino, additional, Fiorini, Giulia, additional, Saracino, Ilaria Maria, additional, Tepes, Bojan, additional, Bordin, Dmitry, additional, Huerga, Alma Keco-, additional, Castro-Fernández, Manuel, additional, Lucendo, Alfredo, additional, Vologzhanina, Liudmila, additional, Bujanda, Luis, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Lanas, Angel, additional, Martínez-Dominguez, Samuel, additional, Alfaro, Enrique, additional, Leja, Marcis, additional, Bumane, Renate, additional, Mammadov, Emin, additional, Babayeva, Gulustan, additional, Mahmudov, Umud, additional, Caldas, María, additional, Rodrigo, Luis, additional, Lerang, Frode, additional, Fadieienko, Galyna, additional, Abdulkhakov, Rustam, additional, Malavés, Jose María Huguet, additional, Zaytsev, Oleg, additional, Ilchishina, Tatiana, additional, Fernández-Salazar, Luis, additional, Alcaide, Noelia, additional, Velayos, Benito, additional, Sarsenbaeva, Aiman Silkanovna, additional, Bakulin, Igor, additional, Gravina, Antonietta G., additional, Romano, Marco, additional, Perona, Mónica, additional, Alekseenko, Sergey, additional, Barrio, Jesús, additional, Areia, Miguel, additional, Nuñez, Óscar, additional, Bogomolov, Pavel, additional, Rodríguez, Blas José Gómez, additional, Cajal, Manuel Dominguez-, additional, Camarero, Judith Gomez, additional, Moreno, Manuel Jiménez, additional, Georgopoulos, Sotirios, additional, Notari, Pedro Almela, additional, Tonkic, Ante, additional, Pellicano, Rinaldo, additional, Simsek, Halis, additional, Kunovský, Lumír, additional, Gasbarrini, Antonio, additional, Bote, Jose Maria Botargues, additional, Buzas, Gyorgy M, additional, Fernández-Bermejo, Miguel, additional, Phull, Perminder, additional, Venerito, Marino, additional, Malfertheiner, Peter, additional, Rosania, Rosa, additional, Link, Alexander, additional, Iyo, Eduardo, additional, Kupinskas, Juozas, additional, Shvets, Oleg, additional, Pinto, Ricardo Marcos, additional, Rokkas, Theodore, additional, Simsek, Ilkay, additional, Smith, Sinead, additional, Boltin, Doron, additional, Lamarque, Dominique, additional, Dobru, Daniela, additional, Marlicz, Wojciech, additional, Milivojevic, Vladimir, additional, Boyanova, Lyudmila, additional, Lamy, Vincent, additional, Doulberis, Michael, additional, Bytzer, Peter, additional, Capelle, Lisette, additional, Gridnyev, Oleksiy, additional, Ristimaki, Ari, additional, Cano-Català, Anna, additional, Puig, Ignasi, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
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26. 130 - COMPARACIÓN DE LA EFECTIVIDAD DE LOS TRATAMIENTOS ERRADICADORES MÁS FRECUENTES ENTRE LAS POBLACIONES MÁS MAYORES Y MÁS JÓVENES DE EUROPA: DATOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Jonaitis, Paulius, primary, Nyssen, Olga P., additional, Saracino, Ilaria Maria, additional, Fiorini, Giulia, additional, Vaira, Dino, additional, Pérez-Aísa, Ángeles, additional, Tepes, Bojan, additional, Castro-Fernández, M., additional, Pabón-Carrasco, Manuel, additional, Keco-Huerga, Alma, additional, Voynovan, Irina, additional, Lucendo, Alfredo J, additional, Lanas, Ángel, additional, Martínez-Domínguez, Samuel J, additional, Almajano, Enrique Alfaro, additional, Rodrigo, Luis, additional, Vologzanina, Ludmila, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Bujanda, Luis, additional, Mahmudov, Umud, additional, Leja, Mrcis, additional, Lerang, Frode, additional, Babayeva, Gülüstan, additional, Bordin, Dmitry S., additional, Gasbarrini, Antonio, additional, Kupcinskas, Juozas, additional, Gridnyev, Oleksiy, additional, Rokkas, Theodore, additional, Marcos-Pinto, Ricardo, additional, Phull, Perminder S., additional, Smith, Sinead M., additional, Tonki, Ante, additional, Boltin, Doron, additional, Buzás, György Miklós, additional, Kunovský, Lumír, additional, imek, Halis, additional, Matysiak-Budnik, Tamara, additional, Milivojevic, Vladimir, additional, Marlicz, Wojciech, additional, Venerito, Marino, additional, Boyanova, Lyudmila, additional, Doulberis, Michael, additional, Capelle, Lisette G., additional, Cano-Català, Anna, additional, Moreira, Leticia, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, Gisbert, Javier P., additional, and Jonaitis, Laimas, additional

Published
2023
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27. 127 - IMPACTO DEL USO DE PROBIÓTICOS EN LA SEGURIDAD DE LOS TRATAMIENTOS FRENTE A HELICOBACTER PYLORI: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Casas, Diego, primary, Alcedo, Javier, additional, Lafuente, Miguel, additional, López, F. Javier, additional, Pérez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Saracino, Ilaria Maria, additional, Tepes, Bojan, additional, Jonaitis, Laimas, additional, Castro-Fernández, Manuel, additional, Pabón-Carrasco, Manuel, additional, Keco-Huerga, Alma, additional, Voynovan, Irina, additional, Bujanda, Luis, additional, Lucendo, Alfredo J., additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Phull, Perminder S., additional, Rodrigo, Luis, additional, Lanas, Angel, additional, Martínez-Domínguez, Samuel J., additional, Alfaro, Enrique, additional, Fadieienko, Galina D., additional, Huguet, Jose M., additional, Bordin, Dmitry S., additional, Gasbarrini, Antonio, additional, Kupcinskas, Juozas, additional, Babayeva, Gülüstan, additional, Gridnyev, Oleksiy, additional, Leja, Mrcis, additional, Rokkas, Theodore, additional, Marcos-Pinto, Ricardo, additional, Lerang, Frode, additional, Boltin, Doron, additional, Papp, Veronika, additional, Tonki, Ante, additional, Smith, Sinead M., additional, Simsek, Halis, additional, Venerito, Marino, additional, Boyanova, Lyudmila, additional, Milivojevic, Vladimir, additional, Kunovsky, Lumir, additional, Matysiak-Budnik, Tamara, additional, Marlicz, Wojciech, additional, Doulberis, Michael, additional, Cano-Català, Anna, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Nyssen, Olga P., additional, Megraud, Francis, additional, Morain, Colm O., additional, and Gisbert, Javier P., additional

Published
2023
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28. 133 - PATRÓN DE PRESCRIPCIÓN DE PROBIÓTICOS ADYUVANTES A LA TERAPIA ERRADICADORA FRENTE A HELICOBACTER PYLORI: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Casas, Diego, primary, Alcedo, Javier, additional, Lafuente, Miguel, additional, López, F. Javier, additional, Pérez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Saracino, Ilaria Maria, additional, Tepes, Bojan, additional, Jonaitis, Laimas, additional, Castro-Fernández, Manuel, additional, Pabón-Carrasco, Manuel, additional, Keco-Huerga, Alma, additional, Voynovan, Irina, additional, Bujanda, Luis, additional, Lucendo, Alfredo J., additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Phull, Perminder S., additional, Rodrigo, Luis, additional, Lanas, Angel, additional, Martínez-Domínguez, Samuel J., additional, Alfaro, Enrique, additional, Fadieienko, Galina D, additional, Huguet, José M., additional, Bordin, Dmitry S., additional, Gasbarrini, Antonio, additional, Kupcinskas, Juozas, additional, Babayeva, Gülüstan, additional, Gridnyev, Oleksiy, additional, Leja, Mrcis, additional, Rokkas, Theodore, additional, Marcos-Pinto, Ricardo, additional, Lerang, Frode, additional, Boltin, Doron, additional, Papp, Veronika, additional, Tonki, Ante, additional, Smith, Sinead M., additional, Simsek, Halis, additional, Venerito, Marino, additional, Boyanova, Lyudmila, additional, Milivojevic, Vladimir, additional, Kunovsky, Lumir, additional, Matysiak-Budnik, Tamara, additional, Marlicz, Wojciech, additional, Doulberis, Michael, additional, Cano-Català, Anna, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Nyssen, Olga P., additional, Megraud, Francis, additional, Morain, Colm O., additional, and Gisbert, Javier P., additional

Published
2023
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29. Empirical rescue treatment ofHelicobacter pyloriinfection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry onH. pylorimanagement (Hp-EuReg)

Author

Burgos-Santamaría, Diego, primary, Nyssen, Olga P, additional, Gasbarrini, Antonio, additional, Vaira, Dino, additional, Pérez-Aisa, Ángeles, additional, Rodrigo, Luís, additional, Pellicano, Rinaldo, additional, Keco-Huerga, Alma, additional, Pabón-Carrasco, Manuel, additional, Castro-Fernandez, Manuel, additional, Boltin, Doron, additional, Barrio, Jesus, additional, Phull, Perminder, additional, Kupcinskas, Juozas, additional, Jonaitis, Laimas, additional, Ortiz-Polo, Inmaculada, additional, Tepes, Bojan, additional, Lucendo, Alfredo J, additional, Huguet, José María, additional, Areia, Miguel, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Bujanda, Luís, additional, Ramos-San Román, June, additional, Cuadrado-Lavín, Antonio, additional, Gomez-Camarero, Judith, additional, Jiménez Moreno, Manuel Alfonso, additional, Lanas, Angel, additional, Martinez-Dominguez, Samuel Jesús, additional, Alfaro, Enrique, additional, Marcos-Pinto, Ricardo, additional, Milivojevic, Vladimir, additional, Rokkas, Theodore, additional, Leja, Marcis, additional, Smith, Sinead, additional, Tonkić, Ante, additional, Buzás, György Miklós, additional, Doulberis, Michael, additional, Venerito, Marino, additional, Lerang, Frode, additional, Bordin, Dmitry S, additional, Lamy, Vincent, additional, Capelle, Lisette G, additional, Marlicz, Wojciech, additional, Dobru, Daniela, additional, Gridnyev, Oleksiy, additional, Puig, Ignasi, additional, Mégraud, Francis, additional, O'Morain, Colm, additional, and Gisbert, Javier P, additional

Published
2022
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32. Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)

Author

Nyssen, Olga P., primary, Vaira, Dino, additional, Pérez Aísa, Ángeles, additional, Rodrigo, Luis, additional, Castro-Fernandez, Manuel, additional, Jonaitis, Laimas, additional, Tepes, Bojan, additional, Vologzhanina, Liudmila, additional, Caldas, María, additional, Lanas, Angel, additional, Lucendo, Alfredo J., additional, Bujanda, Luis, additional, Ortuño, Juan, additional, Barrio, Jesús, additional, Huguet, Jose M., additional, Voynovan, Irina, additional, Lasala, Jorge Perez, additional, Sarsenbaeva, Aiman Silkanovna, additional, Fernandez-Salazar, Luis, additional, Molina-Infante, Javier, additional, Jurecic, Natasa Brglez, additional, Areia, Miguel, additional, Gasbarrini, Antonio, additional, Kupčinskas, Juozas, additional, Bordin, Dmitry, additional, Marcos-Pinto, Ricardo, additional, Lerang, Frode, additional, Leja, Marcis, additional, Buzas, Gyorgy M., additional, Niv, Yaron, additional, Rokkas, Theodore, additional, Phull, Perminder, additional, Smith, Sinead, additional, Shvets, Oleg, additional, Venerito, Marino, additional, Milivojevic, Vladimir, additional, Simsek, Ilkay, additional, Lamy, Vincent, additional, Bytzer, Peter, additional, Boyanova, Lyudmila, additional, Kunovský, Lumír, additional, Beglinger, Christoph, additional, Doulberis, Michael, additional, Marlicz, Wojciech, additional, Goldis, Adrian, additional, Tonkić, Ante, additional, Capelle, Lisette, additional, Puig, Ignasi, additional, Megraud, Francis, additional, Morain, Colm O’, additional, Gisbert, Javier P., additional, Fiorinni, Giulia, additional, Saracino, Ilaria Maria, additional, Carrasco, Manuel Pabon, additional, Huerga, Alma Keco, additional, Almajano, Enrique Alfaro, additional, Martinez Dominguez, Samuel Jesus, additional, Galan, Horacio Alonso, additional, Velayos, Benito, additional, Sadornil, Carmen Dueñas, additional, Botargues Bote, Jose Maria, additional, Gonzalez-Cordero, Pedro Luis, additional, Gomez Rodriguez, Blas Jose, additional, Pellicano, Rinaldo, additional, Nuñez, Óscar, additional, Franceschi, Francesco, additional, Alekseenko, Sergey, additional, Perona, Monica, additional, Abdulkhakov, Rustam, additional, Dominguez-Cajal, Manuel, additional, Notari, Pedro Almela, additional, Camarero, Judith Gomez, additional, Moreno, Manuel Jimenez, additional, Algaba, Alicia, additional, Bermejo, Fernando, additional, Tejada, Javier Tejedor, additional, Susanibar, Elida Oblitas, additional, Boltin, Doron, additional, Georgopoulos, Sotirios, additional, OMorain, Colm, additional, Qasim, Asghar, additional, Beales, Ian, additional, Bakulina, Natalia, additional, Fadeenko, Galina, additional, Malfertheiner, Peter, additional, Rosania, Rosa, additional, Ilchishina, Tatiana, additional, Bogomolov, Pavel, additional, Bakulin, Igor, additional, Zaytsev, Oleg, additional, Gravina, Antonietta Gerarda, additional, Romano, Marco, additional, Di Leo, Alfredo, additional, Losurdo, Giuseppe, additional, Grigorieva, Ludmila, additional, Guillena, Pedro Delgado, additional, Marusic, Marinko, additional, Jurcic, Dragan, additional, Dekhnich, Natalia Nikolaevna, additional, Iyo, Eduardo, additional, de la Peña Negro, Luisa Carmen, additional, Baryshnikova, Natalia, additional, Bakanova, Natalia, additional, Simsek, Halis, additional, Simsek, Cem, additional, Gridnyev, Oleksiy, additional, Fernandez-Bermejo, Miguel, additional, Angueira, Teresa, additional, Ruiz-Zorrilla Lopez, Rafael, additional, Gomez, Barbara, additional, Kovacheva-Slavova, Mila, additional, Lahat, Adi, additional, Alcedo, Javier, additional, Campillo, Ana, additional, Belousova, Liya Nikolaevna, additional, Villarroya, Ramon Pajares, additional, Ljubicic, Neven, additional, Nikolic, Marko, additional, González-Santiago, Jesús M., additional, Santamaría, Diego Burgos, additional, Pakhomova, Anna, additional, Sekulic-Spasic, Izabela, additional, Ghisa, Matteo, additional, Farinati, Fabio, additional, Sagdati, Sabir Irfan, additional, Panic, Nikola, additional, Heluwaert, Frederic, additional, Amorena, Edurne, additional, Moreira, Leticia, additional, Esparrach, Gloria Fernandez, additional, Plotnikova, Ekaterina Yuryevna, additional, Kukla, Michal, additional, Kamburov, Victor, additional, Lamuela Calvo, Luis Javier, additional, Rankovic, Ivan, additional, Lavín, Antonio Cuadrado, additional, Lazaro, Yolanda Arguedas, additional, Carrera Agnieszka Dobrowolska, Victor Gonzalez, additional, Eder, Piotr, additional, and Kononova, Alla, additional

Published
2022
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37. Empirical rescue treatment of Helicobacter pylori infection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry on H. pylori management (Hp-EuReg).

Author

Burgos-Santamaría, Diego, Nyssen, Olga P., Gasbarrini, Antonio, Vaira, Dino, Pérez-Aisa, Ángeles, Rodrigo, Luís, Pellicano, Rinaldo, Keco-Huerga, Alma, Pabón-Carrasco, Manuel, Castro-Fernandez, Manuel, Boltin, Doron, Barrio, Jesus, Phull, Perminder, Kupcinskas, Juozas, Jonaitis, Laimas, Ortiz-Polo, Inmaculada, Tepes, Bojan, Lucendo, Alfredo J., María Huguet, José, and Areia, Miguel

Subjects
HELICOBACTER pylori infections, HELICOBACTER pylori, PATIENTS' attitudes, MEDICAL sciences, MEDICAL education, TREATMENT effectiveness
Published
2023
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39. Experience with Rifabutin-Containing Therapy in 500 Patients from the European Registry on Helicobacter pylori Management (Hp-EuReg)

Author

Medicina, Medikuntza, Nyssen, Olga P., Vaira, Dino, Saracino, Ilaria Maria, Fiorini, Giulia, Caldas, María, Bujanda Fernández de Pierola, Luis, Pellicano, Rinaldo, Keco-Huerga, Alma, Pabón-Carrasco, Manuel, Oblitas Susanibar, Elida, Di Leo, Alfredo, Losurdo, Giuseppe, Pérez-Aísa, Ángeles, Gasbarrini, Antonio, Boltin, Doron, Smith, Sinead, Phull, Perminder, Rokkas, Theodore, Lamarque, Dominique, Cano-Català, Anna, Puig, Ignasi, Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P, Medicina, Medikuntza, Nyssen, Olga P., Vaira, Dino, Saracino, Ilaria Maria, Fiorini, Giulia, Caldas, María, Bujanda Fernández de Pierola, Luis, Pellicano, Rinaldo, Keco-Huerga, Alma, Pabón-Carrasco, Manuel, Oblitas Susanibar, Elida, Di Leo, Alfredo, Losurdo, Giuseppe, Pérez-Aísa, Ángeles, Gasbarrini, Antonio, Boltin, Doron, Smith, Sinead, Phull, Perminder, Rokkas, Theodore, Lamarque, Dominique, Cano-Català, Anna, Puig, Ignasi, Mégraud, Francis, O’Morain, Colm, and Gisbert, Javier P

Abstract

Background: First-line Helicobacter pylori (H. pylori) treatments have been relatively well evaluated; however, it remains necessary to identify the most effective rescue treatments. Our aim was to assess the effectiveness and safety of H. pylori regimens containing rifabutin. METHODS: International multicentre prospective non-interventional European Registry on H. pylori Management (Hp-EuReg). Patients treated with rifabutin were registered in AEG-REDCap e-CRF from 2013 to 2021. Modified intention-to-treat and per-protocol analyses were performed. Data were subject to quality control. Results: Overall, 500 patients included in the Hp-EuReg were treated with rifabutin (mean age 52 years, 72% female, 63% with dyspepsia, 4% with peptic ulcer). Culture was performed in 63% of cases: dual resistance (to both clarithromycin and metronidazole) was reported in 46% of the cases, and triple resistance (to clarithromycin, metronidazole, and levofloxacin) in 39%. In 87% of cases rifabutin was utilised as part of a triple therapy together with amoxicillin and a proton-pump-inhibitor, and in an additional 6% of the patients, bismuth was added to this triple regimen. Rifabutin was mainly used in second-line (32%), third-line (25%), and fourth-line (27%) regimens, achieving overall 78%, 80% and 66% effectiveness by modified intention-to-treat, respectively. Compliance with treatment was 89%. At least one adverse event was registered in 26% of the patients (most frequently nausea), and one serious adverse event (0.2%) was reported in one patient with leukopenia and thrombocytopenia with fever requiring hospitalisation. Conclusion: Rifabutin-containing therapy represents an effective and safe strategy after one or even several failures of H. pylori eradication treatment.

Published
2022

40. Empirical rescue treatment of Helicobacter pylori infection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry on H. pylori management (Hp-EuReg)

Author

Burgos-Santamaría, Diego, Nyssen, Olga P, Gasbarrini, Antonio, Vaira, Dino, Pérez-Aisa, Ángele, Rodrigo, Luí, Pellicano, Rinaldo, Keco-Huerga, Alma, Pabón-Carrasco, Manuel, Castro-Fernandez, Manuel, Boltin, Doron, Barrio, Jesu, Phull, Perminder, Kupcinskas, Juoza, Jonaitis, Laima, Ortiz-Polo, Inmaculada, Tepes, Bojan, Lucendo, Alfredo J, Huguet, José María, Areia, Miguel, Jurecic, Natasa Brglez, Denkovski, Maja, Bujanda, Luí, Ramos-San Román, June, Cuadrado-Lavín, Antonio, Gomez-Camarero, Judith, Jiménez Moreno, Manuel Alfonso, Lanas, Angel, Martinez-Dominguez, Samuel Jesú, Alfaro, Enrique, Marcos-Pinto, Ricardo, Milivojevic, Vladimir, Rokkas, Theodore, Leja, Marci, Smith, Sinead, Tonkić, Ante, Buzás, György Mikló, Doulberis, Michael, Venerito, Marino, Lerang, Frode, Bordin, Dmitry S, Lamy, Vincent, Capelle, Lisette G, Marlicz, Wojciech, Dobru, Daniela, Gridnyev, Oleksiy, Puig, Ignasi, Mégraud, Franci, O'Morain, Colm, Gisbert, Javier P, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Burgos-Santamaría, Diego, Nyssen, Olga P, Gasbarrini, Antonio, Vaira, Dino, Pérez-Aisa, Ángele, Rodrigo, Luí, Pellicano, Rinaldo, Keco-Huerga, Alma, Pabón-Carrasco, Manuel, Castro-Fernandez, Manuel, Boltin, Doron, Barrio, Jesu, Phull, Perminder, Kupcinskas, Juoza, Jonaitis, Laima, Ortiz-Polo, Inmaculada, Tepes, Bojan, Lucendo, Alfredo J, Huguet, José María, Areia, Miguel, Jurecic, Natasa Brglez, Denkovski, Maja, Bujanda, Luí, Ramos-San Román, June, Cuadrado-Lavín, Antonio, Gomez-Camarero, Judith, Jiménez Moreno, Manuel Alfonso, Lanas, Angel, Martinez-Dominguez, Samuel Jesú, Alfaro, Enrique, Marcos-Pinto, Ricardo, Milivojevic, Vladimir, Rokkas, Theodore, Leja, Marci, Smith, Sinead, Tonkić, Ante, Buzás, György Mikló, Doulberis, Michael, Venerito, Marino, Lerang, Frode, Bordin, Dmitry S, Lamy, Vincent, Capelle, Lisette G, Marlicz, Wojciech, Dobru, Daniela, Gridnyev, Oleksiy, Puig, Ignasi, Mégraud, Franci, O'Morain, Colm, Gisbert, Javier P, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Objective To evaluate the use, effectiveness and safety of Helicobacter pylori empirical rescue therapy in third and subsequent treatment lines in Europe. Design International, prospective, non-interventional registry of the clinical practice of European gastroenterologists. Data were collected and quality reviewed until October 2021 at Asociacion Espanola de Gastroenterologia-Research Electronic Data Capture. All cases with three or more empirical eradication attempts were assessed for effectiveness by modified intention-to-treat and per-protocol analysis. Results Overall, 2144 treatments were included: 1519, 439, 145 and 41 cases from third, fourth, fifth and sixth treatment lines, respectively. Sixty different therapies were used; the 15 most frequently prescribed encompassed > 90% of cases. Overall effectiveness remained < 90% in all therapies. Optimised treatments achieved a higher eradication rate than non-optimised (78% vs 67%, p < 0.0001). From 2017 to 2021, only 44% of treatments other than 10-day single-capsule therapy used high proton-pump inhibitor doses and lasted & GE;14 days. Quadruple therapy containing metronidazole, tetracycline and bismuth achieved optimal eradication rates only when prescribed as third-line treatment, either as 10-day single-capsule therapy (87%) or as 14-day traditional therapy with tetracycline hydrochloride (95%). Triple amoxicillin-levofloxacin therapy achieved 90% effectiveness in Eastern Europe only or when optimised. The overall incidence of adverse events was 31%. Conclusion Empirical rescue treatment in third and subsequent lines achieved suboptimal effectiveness in most European regions. Only quadruple bismuth-metronidazole-tetracycline (10-day single-capsule or 14-day traditional scheme) and triple amoxicillin-levofloxacin therapies reached acceptable outcomes in some settings. Compliance with empirical therapy optimisation principles is still poor 5 years after clinical practice guidelines update.

Published
2022

42. Experience with Rifabutin-Containing Therapy in 500 Patients from the European Registry on Helicobacter pylori Management (Hp-EuReg)

Author

Nyssen, Olga P., primary, Vaira, Dino, additional, Saracino, Ilaria Maria, additional, Fiorini, Giulia, additional, Caldas, María, additional, Bujanda, Luis, additional, Pellicano, Rinaldo, additional, Keco-Huerga, Alma, additional, Pabón-Carrasco, Manuel, additional, Oblitas Susanibar, Elida, additional, Di Leo, Alfredo, additional, Losurdo, Giuseppe, additional, Pérez-Aísa, Ángeles, additional, Gasbarrini, Antonio, additional, Boltin, Doron, additional, Smith, Sinead, additional, Phull, Perminder, additional, Rokkas, Theodore, additional, Lamarque, Dominique, additional, Cano-Català, Anna, additional, Puig, Ignasi, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2022
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45. Association of Anemia with Dementia and Cognitive Decline among Community-Dwelling Elderly

Author

Weiss, Avraham, primary, Beloosesky, Yichayaou, additional, Gingold-Belfer, Rachel, additional, Leibovici-Weissman, Yaara, additional, Levy, Yochai, additional, Mulla, Farhan, additional, Issa, Nidal, additional, Boltin, Doron, additional, Koren-Morag, Nira, additional, Meyerovitch, Joseph, additional, Sharon, Eran, additional, and Schmilovitz-Weiss, Hemda, additional

Published
2022
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