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421 results on '"Bombardelli E"'

10. Proanthocyanidin A2: a new polyphenol

Author

Facino, R. Maffei, Carini, M., Brambilla, A., Bombardelli, E., and Morazzoni, P.

Subjects
Polyphenols -- Analysis, Antioxidants -- Analysis, Electron paramagnetic resonance spectroscopy -- Usage, Skin -- Physiological aspects, Business, Pharmaceuticals and cosmetics industries
Abstract

This Aesculus hippocastanum derivative is a strong scavenger of free radicals and inhibitor of proteases and glycosidases(a) We study the antioxidant activity of proanthocyanidin [A.sub.2], a new polyphenol from Aesculus [...]

Published
1996

11. Proposed etiology and therapeutic management of local lipodystrophy and districtual microcirculation

Author

Curri, S.B. and Bombardelli, E.

Subjects
Obesity -- Analysis, Fat cells -- Analysis, Diseases -- Causes and theories of causation, Business, Pharmaceuticals and cosmetics industries
Abstract

Increased thickness of the subcutaneous fat pad is thought to result from increased volume of the adipose cells (hypertrophy), rather than increased number (hyperplasia). The term 'local adiposity' describes the [...]

Published
1994

12. Botanical derivatives in functional cosmetics

Author

Bombardelli, E.

Subjects
Toiletries -- Usage, Lipid research -- Management -- Usage -- Research, Fatty acids -- Usage, Cosmetics industry -- Research -- Usage, Medicinal plants -- Usage, Pharmaceutical industry -- Research -- Usage, Business, Pharmaceuticals and cosmetics industries, Company business management, Management, Usage, Research
Abstract

'Folk medicine has been the basis for much of the use of plant derivatives in medicines and cosmetics, and remains an important source as to their efficacy. But today historical [...]

Published
1994

13. Phospholipid-polyphenol complexes: a new concept in skin care ingredients

Author

Bombardelli, E.

Subjects
Phospholipids -- Research, Flavonoids -- Research, Cosmetics industry -- Research, Business, Pharmaceuticals and cosmetics industries
Abstract

Phospholipid--Polyphenol Complexes: A New Concept in Skin Care Ingredients As a part of a research program dealing with the cosmetic activity of botanical derivatives, we have focused our attention in [...]

Published
1991

16. Attempted oxidative deamination of N-deacetylcolchicinoids with 3,5-di(tert-butyl)-1,2-benzoquinone: Synthesis of 2H-1,4-benzoxazine-type adducts

Author

Danieli, B, Lesma, G, Passarella, D, Prosperi, D, Silvani, A, Bombardelli, E, Bombardelli, E., PROSPERI, DAVIDE, Danieli, B, Lesma, G, Passarella, D, Prosperi, D, Silvani, A, Bombardelli, E, Bombardelli, E., and PROSPERI, DAVIDE

Abstract

In an attempt to use 3,5-di(tert-butyl)-1,2-benzoquinone for the oxidative deamination of N-deacetylcolchicine (4) and N-deacetylthiocolchicine (= N-deacetyl-10-demethoxy-10-(methylthio)colchicine; 5) to give the corresponding ketones 2 and 3, the 2H-1,4-benzoxazine-type adducts 8/9 and 11/12. respectively, were formed instead, showing a new and unexpected behavior of Corey's reagent. The adducts were separated and spectroscopically characterized, and a plausible scheme of formation is reported

Published
1999

31. Effect of Soyselect (a standardized soy extract) on reproductive and non reproductive tissues in rats

Author

Gallo, D., Giacomelli, S., Apollonio, P., Zannoni, G.F., Ferlini, A., Riva, A., Morazzoni, P., Bombardelli, E., Mancuso, S., and Scambia, G.

Subjects
Soybean products -- Health aspects, Soybean products -- Research, Soy protein -- Health aspects, Soy protein -- Research, Hormone therapy -- Health aspects, Hormone therapy -- Research, Food/cooking/nutrition
Abstract

Hormone replacement therapy (HRT) is currently viewed as a strategy for treating climacteric complaints and preventing osteoporosis; however, because of the augmented risks of breast cancer, stroke, and venous thromboembolism, patients look for alternatives. The efficacy of Soyselect (a standardized soy extract containing 12% w/w isoflavone glucosides) in the treatment of menopausal symptoms has been established in previous clinical studies (1,2). The main objective of the present study was to evaluate the osteoprotective activity of the extract in an experimental model of menopause and to correlate the effects observed with isoflavone plasma levels; other potential treatment-related effects, such as those on lipid profile and those indicative of toxicity have been also assessed. For the purpose of the study, Sprague Dawley female rats were ovariectomized or sham operated at age 3 mo and subsequently treated for 6 wk. Ovariectomized animals (12/group) received either the soy extract [50 or 100 mg/(kg*d) per os], the vehicle, or [beta]-estradiol [0.5 mg/(kg*d) per os]. At the end of the study rats were killed and blood and organs were collected for subsequent analyses. Bone density analysis showed that soy treatment significantly [P < 0.01 at 100 mg/(kg*d)] reduced bone loss in ovarian hormone deficiency. Remarkably, this osteoprotective effect was not accompanied by a stimulatory effect on the uterus, as demonstrated by organ weight data and by histopathological analysis. In immature rats, a lack of uterine stimulatory effect was also observed after administration of the same dosages of the extract. Minor changes were observed in lipid profile of ovariectomized rats after soy administration. Total genistein, daidzein, and equol plasma levels (mean [+ or -] SD) were found to be 0.9 [+ or -] 0.5, 1.5 [+ or -] 0.5, and 2.3 [+ or -] 0.8 [micro]mol/L, respectively, in the low-dose group and 2.6 [+ or -] 1.7, 3.3 [+ or -] 1.6, and 2.3 [+ or -] 1.5 [micro]mol/L, respectively, in the high-dose group. Further studies are now ongoing in our laboratory to thoroughly characterize the pharmacological properties of this soy extract both in terms of therapeutic and safety aspects.

Published
2004

43. Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxel

Author

Battaglia A, Bertucci C, Bombardelli E, Cimitan S, Guerrini A, Morazzoni P, and Riva A

Abstract

A water soluble paclitaxel analogue, the 7-hemisuccinylpaclitaxel, was synthesised and its binding to human serum albumin (HSA) was characterised by difference circular dichroism and optical biosensor methodologies. The carboxylate group was introduced at paclitaxel C-7 position to improve the drug water solubility without significantly changing the biological activity. The paclitaxel analogue showed a relatively low affinity to HSA (3.5 x 10(4) M-1), while no significant interactions were evidenced with selective markers for the most characterised binding sites on the carrier, suggesting a non-selective binding to low affinity binding sites. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

Published
2003

44. Diastereoselective 14 beta-hydroxylation of baccatin III derivatives

Author

Battaglia A, Baldelli E, Bombardelli E, Carenzi G, Fontana G, Gambini A, Gelmi ML, Guerrini A, and Pocar D

Subjects
TAXOL ANALOGS, RESISTANCE, Reduction
Abstract

14beta-Hydroxybaccatin III, a compound with limited availability by natural sources, is the starting material for the synthesis of the second-generation anticancer taxoid ortataxel. The 7-tertbutoxycarbonyl- (1a) and 7-triethylsilyl (1b) derivatives of 14beta-hydroxybaccatin III 1,14-carbonate were synthesized from 10-deacetylbaccatin III (3). The crucial steps were (a) the C(14)beta hydroxylation of the corresponding 13-oxobaccatin III derivatives by oxaziridine-mediated electrophilic oxidation and (b) the reduction of the C-13 carbonyl group with sodium or alkylammonium borohydrides. This protocol provides a practical way for the semisynthesis of ortataxel from 10-deacetylbaccatin III, a compound readily available from various yews.

Published
2003

47. Synthesis and biological evaluation of 2 '-methyl taxoids derived from baccatin III and 14 beta-OH-baccatin III 1,14-carbonate

Author

Battaglia A, Bernacki RJ, Bertucci C, Bombardelli E, Cimitan S, Ferlini C, Fontana G, Guerrini A, and Riva A

Subjects
EFFICIENT SYNTHESIS, TAXOL(R) ANALOGS, ANTITUMOUR, RESISTANT
Abstract

A series of 2-methyl taxoids were synthesized and essayed for growth inhibition experiments conducted in human ovarian cancer cell line A2780wt and its counterparts A2780cis, A2780tax, and A2780adr, resistant to cisplatin, paclitaxel, and doxorubicin, respectively, to test the effect of this substituent on the antitumor activity. Additional experiments were performed on MCF-7 human breast cancer cell line and MCF7-R resistant to doxorubicin. In several cases these taxoids were more active than paclitaxel showing subnanomolar IC50 values.

Published
2003

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