1. Bombardolides: New Antifungal and Antibacterial γ-Lactones from the Coprophilous Fungus Bombardioidea anartia
- Author
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David Malloch, James B. Gloer, Brenda Koster, and Sara M. Hein
- Subjects
Antifungal ,Antifungal Agents ,Magnetic Resonance Spectroscopy ,medicine.drug_class ,Stereochemistry ,Pharmaceutical Science ,Microbial Sensitivity Tests ,Fungus ,Spectrometry, Mass, Fast Atom Bombardment ,Analytical Chemistry ,Feces ,Lactones ,Anti-Infective Agents ,Drug Discovery ,medicine ,Animals ,Bombardioidea anartia ,Candida albicans ,Chromatography, High Pressure Liquid ,Antibacterial agent ,Pharmacology ,chemistry.chemical_classification ,Xylariales ,Traditional medicine ,biology ,Chemistry ,Deer ,Organic Chemistry ,Fungi imperfecti ,biology.organism_classification ,Complementary and alternative medicine ,Molecular Medicine ,Lactone - Abstract
Chemical studies of organic extracts from cultures of the coprophilous fungus Bombardioidea anartia have led to the discovery of bombardolides A--D (1--4), a series of new antifungal and antibacterial metabolites. Three of these metabolites (1--3) were obtained as inseparable pairs of geometric isomers. A new 3-substituted phenol (5) and the known compound asterriquinone B4 were also encountered. The structures of compounds 1--5 were determined by analysis of NMR and MS data.
- Published
- 2001
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