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25 results on '"Bombin, Andrei"'

2. The Burden and Impact of Early Post-transplant Multidrug-Resistant Organism Detection Among Renal Transplant Recipients, 2005–2021

Author

Babiker, Ahmed, primary, Karadkhele, Geeta, additional, Bombin, Andrei, additional, Watkins, Rockford, additional, Robichaux, Chad, additional, Smith, Gillian, additional, Beechar, Vivek B, additional, Steed, Danielle B, additional, Jacobs, Jesse T, additional, Read, Timothy D, additional, Satola, Sarah, additional, Larsen, Christian P, additional, Kraft, Colleen S, additional, Pouch, Stephanie M, additional, and Woodworth, Michael H, additional

Published
2024
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3. ABO O blood group as a risk factor for platelet reactivity in heparin-induced thrombocytopenia

Author

Karnes, Jason H., Rollin, Jerome, Giles, Jason B., Martinez, Kiana L., Steiner, Heidi E., Shaffer, Christian M., Momozawa, Yukihide, Inai, Chihiro, Bombin, Andrei, Shi, Mingjian, Mosley, Jonathan D., Stanaway, Ian, Selleng, Kathleen, Thiele, Thomas, Mushiroda, Taisei, Pouplard, Claire, Heddle, Nancy M., Kubo, Michiaki, Phillips, Elizabeth J., Warkentin, Theodore E., Gruel, Yves, Greinacher, Andreas, and Roden, Dan M.

Published
2022
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5. 2469. Comparative Genomics Uncovers Strain Diversity and Possible Unrecognized Transmission of MDROs among Hospitalized Patients

Author

Koundakjian, Dylan, primary, Strudwick, Amanda F, additional, Page, Alex, additional, Van Riel, Julia, additional, Gooden, D’Ante, additional, Satola, Sarah W, additional, Bombin, Andrei, additional, Read, Timothy D, additional, Jacob, Jesse T, additional, Babiker, Ahmed, additional, and Woodworth, Michael H, additional

Published
2023
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6. Viral and host factors associated with SARS-CoV-2 disease severity in Georgia, USA

Author

Carmola, Ludy R., primary, Roebling, Allison Dorothy, additional, Khosravi, Dara, additional, Langsjoen, Rose M., additional, Bombin, Andrei, additional, Bixler, Bri, additional, Reid, Alex, additional, Chen, Cara, additional, Wang, Ethan, additional, Lu, Yang, additional, Zheng, Ziduo, additional, Zhang, Rebecca, additional, Nguyen, Phuong-Vi, additional, Arthur, Robert A., additional, Fitts, Eric, additional, Gulick, Dalia Arafat, additional, Higginbotham, Dustin, additional, Taz, Azmain, additional, Ahmed, Alaa, additional, Crumpler, John Hunter, additional, Kraft, Colleen, additional, Lam, Wilbur A., additional, Babiker, Ahmed, additional, Waggoner, Jesse J., additional, Openo, Kyle P., additional, Johnson, Laura M., additional, Westbrook, Adrianna, additional, and Piantadosi, Anne, additional

Published
2023
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9. Genomic Epidemiology of a SARS-CoV-2 Outbreak in a U.S. Major League Soccer Club: Was it travel related?

Author

Carmola, Ludy R, primary, Turcinovic, Jacquelyn, additional, Draper, Garrison, additional, Webner, David, additional, Putukian, Margot, additional, Silvers-Granelli, Holly, additional, Bombin, Andrei, additional, Connor, Bradley A, additional, Angelo, Kristina, additional, Kozarsky, Phyllis, additional, Libman, Michael, additional, Huits, Ralph, additional, Hamer, Davidson H, additional, Fairley, Jessica K, additional, Connor, John H, additional, Piantadosi, Anne, additional, and Bourque, Daniel L, additional

Published
2023
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11. Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV

Author

Khosravi, Dara, primary, Soloff, Hannah, additional, Langsjoen, Rose M, additional, Bombin, Andrei, additional, Kelley, Colleen F, additional, Ray, Susan M, additional, Gunthel, Clifford J, additional, Zanoni, Brian C, additional, Nguyen, Phuong-Vi, additional, Waggoner, Jesse J, additional, Wang, Yun F, additional, Cantos, Valeria D, additional, and Piantadosi, Anne, additional

Published
2023
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12. Phylodynamics of deer tick virus in North America

Author

McMinn, Rebekah J, primary, Langsjoen, Rose M, additional, Bombin, Andrei, additional, Robich, Rebecca M, additional, Ojeda, Erick, additional, Normandin, Erica, additional, Goethert, Heidi K, additional, Lubelczyk, Charles B, additional, Schneider, Elizabeth, additional, Cosenza, Danielle, additional, Meagher, Molly, additional, Prusinski, Melissa A, additional, Sabeti, Pardis C, additional, Smith, Robert P, additional, Telford, Sam, additional, Piantadosi, Anne, additional, and Ebel, Gregory D, additional

Published
2023
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13. Genomic Epidemiology of a Severe Acute Respiratory Syndrome Coronavirus 2 Outbreak in a US Major League Soccer Club: Was It Travel Related?

Author

Carmola, Ludy R, Turcinovic, Jacquelyn, Draper, Garrison, Webner, David, Putukian, Margot, Silvers-Granelli, Holly, Bombin, Andrei, Connor, Bradley A, Angelo, Kristina M, Kozarsky, Phyllis, Libman, Michael, Huits, Ralph, Hamer, Davidson H, Fairley, Jessica K, Connor, John H, Piantadosi, Anne, and Bourque, Daniel L

Abstract

Background Professional soccer athletes are at risk of acquiring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). United States Major League Soccer (MLS) uses protocol-based SARS-CoV-2 testing for identification of individuals with coronavirus disease 2019. Methods Per MLS protocol, fully vaccinated players underwent SARS-CoV-2 real-time polymerase chain reaction testing weekly; unvaccinated players were tested every other day. Demographic and epidemiologic data were collected from individuals who tested positive, and contact tracing was performed. Whole genome sequencing (WGS) was performed on positive specimens, and phylogenetic analyses were used to identify potential transmission patterns. Results In the fall of 2021, all 30 players from 1 MLS team underwent SARS-CoV-2 testing per protocol; 27 (90%) were vaccinated. One player who had recently traveled to Africa tested positive for SARS-CoV-2; within the following 2 weeks, 10 additional players and 1 staff member tested positive. WGS yielded full genome sequences for 10 samples, including 1 from the traveler. The traveler's sample was Delta sublineage AY.36 and was closely related to a sequence from Africa. Nine samples yielded other Delta sublineages including AY.4 (n = 7), AY.39 (n = 1), and B.1.617.2 (n = 1). The 7 AY.4 sequences clustered together; suggesting a common source of infection. Transmission from a family member visiting from England to an MLS player was identified as the potential index case. The other 2 AY.4 sequences differed from this group by 1–3 nucleotides, as did a partial genome sequence from an additional team member. Conclusions WGS is a useful tool for understanding SARS-CoV-2 transmission dynamics in professional sports teams. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Symbiotic bacterial community of Drosophila melanogaster changes with nutritional modifications of the diet but can alleviate negative effects on larval phenotypes

Author

Bombin, Andrei, primary, Cunneely, Owen, additional, Bombin, Sergei, additional, Eickman, Kira, additional, Ruesy, Abigail, additional, Cowan, Rachael, additional, Myers, Abigail, additional, Su, Mengting, additional, Mosley, Jonathan, additional, Ferguson, Jane, additional, and Reed, Laura, additional

Published
2021
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20. ABOO blood group as a risk factor for platelet reactivity in heparin-induced thrombocytopenia

Author

Karnes, Jason H, Rollin, Jerome, Giles, Jason B, Martinez, Kiana L, Steiner, Heidi E, Shaffer, Christian M, Momozawa, Yukihide, Inai, Chihiro, Bombin, Andrei, Shi, Mingjian, Mosley, Jonathan D, Stanaway, Ian, Selleng, Kathleen, Thiele, Thomas, Mushiroda, Taisei, Pouplard, Claire, Heddle, Nancy M, Kubo, Michiaki, Phillips, Elizabeth J, Warkentin, Theodore E, Gruel, Yves, Greinacher, Andreas, and Roden, Dan M

Abstract

Heparin-induced thrombocytopenia (HIT) is an unpredictable, potentially catastrophic adverse effect resulting from an immune response to platelet factor 4 (PF4)/heparin complexes. We performed a genome-wide association study with positive functional assay as the outcome in a large discovery cohort of patients divided into three groups: (1) functional assay-positive cases (n=1269), (2) antibody-positive (functional assay-negative) controls (n=1131), and (3) antibody-negative controls (n=1766). Significant associations (alpha=5x10-8) were investigated in a replication cohort (alpha=0.05) of functional assay-confirmed HIT cases (n=177), antibody-positive (function assay-negative) controls (n=258), and antibody negative controls (n=351). We observed a strong association for positive functional assay with increasing PF4/heparin IgG level (odds ratio [OR] 16.53[95% confidence interval 13.83-19.74], p=1.51x10-209) and female sex (OR 1.15[1.01-1.32], p=0.034). The rs8176719 C insertion variant in ABOwas significantly associated with positive functional assay status in the discovery cohort (frequency=0.41; OR 0.751[0.682-0.828], p=7.80x10-9) and in the replication cohort (OR 0.467 [0.228-0.954], p=0.0367). The rs8176719 C insertion, which encodes all non-O blood group alleles, had a protective effect, indicating that the rs8176719 C deletion and the O blood group was a risk factor for HIT (O blood group OR 1.42 [1.26-1.61], p=3.09x10-8). Meta-analyses indicated that the ABOassociation was independent of PF4/heparin IgG levels and was stronger when functional assay-positive cases were compared to antibody-positive (functional assay-negative) controls than to antibody-negative controls. Sequencing and fine-mapping of ABOdemonstrated that rs8176719 was the causal SNP. Our results clarify the biology underlying HIT pathogenesis with ramifications for prediction and may have important implications for related conditions, such as vaccine-induced thrombotic thrombocytopenia.

Published
2024
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22. The changing biodiversity of Alabama Drosophila: important impacts of seasonal variation, urbanization, and invasive species.

Author

Bombin, Andrei and Reed, Laura K.

Subjects
*GLOBAL warming, *BIOSPHERE, *BIODIVERSITY, *DROSOPHILA, *ANTHROPOGENIC effects on nature
Abstract

Global warming and anthropogenic disturbances significantly influence the biosphere, tremendously increasing species extinction rates. In Central Alabama, we analyzed Drosophilidae species composition change nearly 100 years after the previous survey. We found ten Drosophilid species that were not reported during the last major biodiversity studies, two of which are invasive pests. In addition, we analyzed the influence of seasonal environmental variables characteristic of the subtropical climate zone on Drosophila abundance and biodiversity. We found a significant correlation between temperature and abundance of total Drosophila as well as for six of the seven most represented species individually, with a maximum abundance at intermediate temperatures (18-26°C). In addition, temperature was positively correlated with biodiversity of Drosophila. Precipitation produced a significant effect on the abundance of five species of Drosophila, with different optima for each species, but did not affect overall biodiversity. We concluded that in the subtropical climate zone of Central Alabama, seasonal temperature and precipitation changes produce a significant effect on Drosophila abundance and biodiversity, while local land use also impacts fly abundance, contributing to an apparent shift in species composition over the last century. We expect global climate change and other anthropogenic factors to further impact Drosophila species composition in the subtropical climate zone into the future. [ABSTRACT FROM AUTHOR]

Published
2016
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23. EMERGENT Lab Poster (PI: Dr. Timothy Read)

Author

Raghuram, Vishnu, Read, Timothy, Alexander, M. Ashley, Bombin, Andrei, Brianna, J. Bixler, Talbot, M. Brooke, Wissel, F. Emily, Robinson, C. Jacoby, Hofstetter, S. Katrina, and Jijakli, Kenan

Abstract

Poster showing members and recent research from Dr. Timothy Read's Lab (Emory University) as of 2022, March 25.&nbsp

Published
2022
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24. Viral and host factors associated with SARS-CoV-2 disease severity in Georgia, USA.

Author

Carmola LR, Roebling AD, Khosravi D, Langsjoen RM, Bombin A, Bixler B, Reid A, Chen C, Wang E, Lu Y, Zheng Z, Zhang R, Nguyen PV, Arthur RA, Fitts E, Gulick DA, Higginbotham D, Taz A, Ahmed A, Crumpler JH, Kraft C, Lam WA, Babiker A, Waggoner JJ, Openo KP, Johnson LM, Westbrook A, and Piantadosi A

Abstract

While SARS-CoV-2 vaccines have shown strong efficacy, their suboptimal uptake combined with the continued emergence of new viral variants raises concerns about the ongoing and future public health impact of COVID-19. We investigated viral and host factors, including vaccination status, that were associated with SARS-CoV-2 disease severity in a setting with low vaccination rates. We analyzed clinical and demographic data from 1,957 individuals in the state of Georgia, USA, coupled with viral genome sequencing from 1,185 samples. We found no difference in disease severity between individuals infected with Delta and Omicron variants among the participants in this study, after controlling for other factors, and we found no specific mutations associated with disease severity. Compared to those who were unvaccinated, vaccinated individuals experienced less severe SARS-CoV-2 disease, and the effect was similar for both variants. Vaccination within 270 days before infection was associated with decreased odds of moderate and severe outcomes, with the strongest association observed at 91-270 days post-vaccination. Older age and underlying health conditions, especially immunosuppression and renal disease, were associated with increased disease severity. Overall, this study provides insights into the impact of vaccination status, variants/mutations, and clinical factors on disease severity in SARS-CoV-2 infection when vaccination rates are low. Understanding these associations will help refine and reinforce messaging around the crucial importance of vaccination in mitigating the severity of SARS-CoV-2 disease., Competing Interests: Competing interests: The authors have declared that no competing interests exist.

Published
2023
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25. Genotype-based "virtual" metabolomics in a clinical biobank identifies novel metabolite-disease associations.

Author

Bagheri M, Bombin A, Shi M, Murthy VL, Shah R, Mosley JD, and Ferguson JF

Abstract

Circulating metabolites act as biomarkers of dysregulated metabolism, and may inform disease pathophysiology. A portion of the inter-individual variability in circulating metabolites is influenced by common genetic variation. We evaluated whether a genetics-based "virtual" metabolomics approach can identify novel metabolite-disease associations. We examined the association between polygenic scores for 726 metabolites (derived from OMICSPRED) with 1,247 clinical phenotypes in 57,735 European ancestry and 15,754 African ancestry participants from the BioVU DNA Biobank. We probed significant relationships through Mendelian randomization (MR) using genetic instruments constructed from the METSIM Study, and validated significant MR associations using independent GWAS of candidate phenotypes. We found significant associations between 336 metabolites and 168 phenotypes in European ancestry and 107 metabolites and 56 phenotypes among African ancestry. Of these metabolite-disease pairs, MR analyses confirmed associations between 73 metabolites and 53 phenotypes in European ancestry. Of 22 metabolite-phenotype pairs evaluated for replication in independent GWAS, 16 were significant (false discovery rate p<0.05). Validated findings included the metabolites bilirubin and X-21796 with cholelithiasis, phosphatidylcholine(16:0/22:5n3,18:1/20:4) and arachidonate(20:4n6) with inflammatory bowel disease and Crohn's disease, and campesterol with coronary artery disease and myocardial infarction. These associations may represent biomarkers or potentially targetable mediators of disease risk.

Published
2023
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