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26 results on '"Bonacchi, Daniele"'

13. Gold nanoparticles induce cytotoxicity in the alveolar type-II cell lines A549 and NCIH441

Author

Unger Ronald E, Baldi Giovanni, Pohl Christine, Lorenzi Giada, Hermanns M Iris, Bonacchi Daniele, Uboldi Chiara, and Kirkpatrick C James

Subjects
Toxicology. Poisons, RA1190-1270, Industrial hygiene. Industrial welfare, HD7260-7780.8
Abstract

Abstract Background During the last years engineered nanoparticles (NPs) have been extensively used in different technologies and consequently many questions have arisen about the risk and the impact on human health following exposure to nanoparticles. Nevertheless, at present knowledge about the cytotoxicity induced by NPs is still largely incomplete. In this context, we have investigated the cytotoxicity induced by gold nanoparticles (AuNPs), which differed in size and purification grade (presence or absence of sodium citrate residues on the particle surface) in vitro, in the human alveolar type-II (ATII)-like cell lines A549 and NCIH441. Results We found that the presence of sodium citrate residues on AuNPs impaired the viability of the ATII-like cell lines A549 and NCIH441. Interestingly, the presence of an excess of sodium citrate on the surface of NPs not only reduced the in vitro viability of the cell lines A549 and NCIH441, as shown by MTT assay, but also affected cellular proliferation and increased the release of lactate dehydrogenase (LDH), as demonstrated by Ki-67 and LDH-release assays respectively. Furthermore, we investigated the internalization of AuNPs by transmission electron microscopy (TEM) and we observed that particles were internalized by active endocytosis in the cell lines A549 and NCIH441 within 3 hr. In addition, gold particles accumulated in membrane-bound vesicles and were not found freely dispersed in the cytoplasm. Conclusion Our data suggest that the presence of contaminants, such as sodium citrate, on the surface of gold nanoparticles might play a pivotal role in inducing cytotoxicity in vitro, but does not influence the uptake of the particles in human ATII-like cell lines.

Published
2009
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14. Advances in Single-Molecule Magnet Surface Patterning through Microcontact Printing

Author

Mannini, Matteo, Bonacchi, D., Bonacchi, Daniele, Zobbi, Laura, Piras, Federica M., Speets, E.A., Caneschi, Andrea, Cornia, Andrea, Magnani, Agnese, Ravoo, B.J., Reinhoudt, David, Sessoli, Roberta, Gatteschi, Dante, and Inorganic Materials Science

Subjects
Nanostructure, Surface Properties, Bioengineering, Nanotechnology, IR-53105, Magnetics, Cluster (physics), micro-contact printing, General Materials Science, Single-molecule magnet, single-molecule magnets, Particle Size, Lithography, METIS-225409, Manganese, Chemistry, Mechanical Engineering, Self-assembled monolayer, General Chemistry, Condensed Matter Physics, Nanostructures, self-assembled monolayers, mass spectrometry, lithography, manganese, cluster complexes, Secondary ion mass spectrometry, Magnet, Microcontact printing, Printing, AFM, ToF-SIMS, Crystallization
Abstract

We present an implementation of strategies to deposit single-molecule magnets (SMMs) using microcontact printing microCP). We describe different approaches of microCP to print stripes of a sulfur-functionalized dodecamanganese (III, IV) cluster on gold surfaces. Comparison by atomic force microscopy profile analysis of the patterned structures confirms the formation of a chemically stable single layer of SMMs. Images based on chemical contrast, obtained by time-of-flight secondary ion mass spectrometry, confirm the patterned structure.

Published
2005
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15. Bovine Serum Albumin‐Based Magnetic Nanocarrier for MRI Diagnosis and Hyperthermic Therapy: A Potential Theranostic Approach Against Cancer

Author

Comes Franchini, Mauro, primary, Baldi, Giovanni, additional, Bonacchi, Daniele, additional, Gentili, Denis, additional, Giudetti, Guido, additional, Lascialfari, Alessandro, additional, Corti, Maurizio, additional, Marmorato, Patrick, additional, Ponti, Jessica, additional, Micotti, Edoardo, additional, Guerrini, Uliano, additional, Sironi, Luigi, additional, Gelosa, Paolo, additional, Ravagli, Costanza, additional, and Ricci, Alfredo, additional

Published
2010
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19. Isolated single-molecule magnets on native gold

Author

Zobbi, Laura, primary, Mannini, Matteo, additional, Pacchioni, Mirko, additional, Chastanet, Guillaume, additional, Bonacchi, Daniele, additional, Zanardi, Chiara, additional, Biagi, Roberto, additional, Pennino, Umberto Del, additional, Gatteschi, Dante, additional, Cornia, Andrea, additional, and Sessoli, Roberta, additional

Published
2005
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23. Direct Observation of Single-Molecule Magnets Organized on Gold Surfaces

Author

Cornia, Andrea, primary, Fabretti, Antonio C., additional, Pacchioni, Mirko, additional, Zobbi, Laura, additional, Bonacchi, Daniele, additional, Caneschi, Andrea, additional, Gatteschi, Dante, additional, Biagi, Roberto, additional, Del Pennino, Umberto, additional, De Renzi, Valentina, additional, Gurevich, Leonid, additional, and Van der Zant, Herre S. J., additional

Published
2003
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24. Site-specific ligation of anthracene-1,8-dicarboxylates to an Mn12core: a route to the controlled functionalisation of single-molecule magnetsElectronic supplementary information (ESI) available: Fig. A: Hystereses curves recorded at different temperature at 5 kOe min−1on an oriented single crystal of 3. Fig. B: First derivative of the hysteresis curve recorded at 2.1 K. See http://www.rsc.org/suppdata/cc/b4/b411320a/

Author

Pacchioni, Mirko, Cornia, Andrea, Fabretti, Antonio C., Zobbi, Laura, Bonacchi, Daniele, Caneschi, Andrea, Chastanet, Guillaume, Gatteschi, Dante, and Sessoli, Roberta

Abstract

A novel single-molecule magnet of the Mn12family, Mn12O12O2CC6H58L4H2O4·8CH2Cl2, has been synthesised by site-specific ligand exchange using a tailor-made dicarboxylate L2−, which leads to selective occupation of axial binding sites.

Published
2004
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