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11 results on '"Bonacina, Manuela"'

1. Diagnostic Applications of Nuclear Medicine: Prostatic Cancer

Author

Evangelista, Laura, Ceresoli, Giovanni Luca, Setti, Lucia, Garbaccio, Viviana, Olivari, Laura, Bonacina, Manuela, Sauta, Maria Grazia, Ciocia, Gianluigi, Vavassori, Vittorio, Villa, Elisa, Meroni, Roberta, Bombardieri, Emilio, Volterrani, Duccio, editor, Erba, Paola A., editor, Strauss, H. William, editor, Mariani, Giuliano, editor, and Larson, Steven M., editor

Published
2022
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2. The Evaluation of Radiolabeled Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography for Initial Staging in Intermediate-Risk Prostate Cancer Patients: A Retrospective Multicenter Analysis.

Author

Evangelista, Laura, Guglielmo, Priscilla, Giacoppo, Giulia, Setti, Lucia, Aricò, Demetrio, Muraglia, Lorenzo, Marzo, Katia, Buffi, Nicolò, Fasulo, Vittorio, Rodari, Marcello, Jandric, Jelena, Salvaggio, Antonio, Bonacina, Manuela, Lazzeri, Massimo, and Lughezzani, Giovanni

Subjects
PROSTATE-specific membrane antigen, POSITRON emission tomography, PROSTATE cancer patients, COMPUTED tomography, LYMPHATIC metastasis
Abstract

Objectives. The aim of the present study was to assess the performance of radiolabeled-PSMA PET/CT in a cohort of intermediate-risk prostate cancer (PCa) patients for initial staging. Methods. This is a retrospective, multicenter analysis of patients diagnosed with intermediate-risk PCa who were staged using radiolabeled PSMA PET/CT to evaluate the extent of the disease before initiating appropriate treatment. The study included patients from the Nuclear Medicine Units of the Humanitas group between 2021 and 2024. The change in management due to the PSMA PET/CT examination was assessed. Results. A total of 181 patients were enrolled across all three centers. Histopathological assessment from biopsy revealed that 51.4% of patients had favorable PCa, while 48.6% had unfavorable disease. PET/CT was positive for the primary lesions in all patients, but it revealed a positivity rate in 23 (12.7%) patients for nodes and distant organs, with a positivity rate of 0.21 in the unfavorable group and 0.05 in the favorable group (p < 0.005). Based on follow-up data, diagnostic accuracy was higher than 90% in both the favorable and unfavorable groups for lymph node and distant metastases. The inclusion of PSMA PET/CT in the diagnostic algorithm for patients with intermediate-risk PCa impacted patient management in 24 (13.3%) cases, based on the multidisciplinary team decision. Conclusions. PSMA PET/CT can affect the management of patients with intermediate-risk PCa in up to 13% of cases, mainly for unfavorable diseases. New imaging techniques as a first-line imaging procedure can help to plan the correct therapeutic approach in the intermediate-risk PCa group. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Combining positron emission tomography/computed tomography, radiomics, and sentinel lymph node mapping for nodal staging of endometrial cancer patients

Author

Crivellaro, Cinzia, Landoni, Claudio, Elisei, Federica, Buda, Alessandro, Bonacina, Manuela, Grassi, Tommaso, Monaco, Lavinia, Giuliani, Daniela, Gotuzzo, Irene, Magni, Sonia, Di Martino, Giampaolo, Delle Marchette, Martina, Guerra, Luca, Landoni, Fabio, Fruscio, Robert, Messa, Cristina, and De Bernardi, Elisabetta

Published
2020
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8. Prognostic value of CT integrated with clinical and laboratory data during the first peak of the COVID-19 pandemic in Northern Italy: A nomogram to predict unfavorable outcome

Author

Angeli, Enzo, primary, Dalto, Serena, additional, Marchese, Stefano, additional, Setti, Lucia, additional, Bonacina, Manuela, additional, Galli, Francesca, additional, Rulli, Eliana, additional, Torri, Valter, additional, Monti, Cinzia, additional, Meroni, Roberta, additional, Beretta, Giordano Domenico, additional, Castoldi, Massimo, additional, and Bombardieri, Emilio, additional

Published
2021
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10. Combining positron emission tomography/computed tomography, radiomics, and sentinel lymph node mapping for nodal staging of endometrial cancer patients

Author

Crivellaro, C, Landoni, C, Elisei, F, Buda, A, Bonacina, M, Grassi, T, Monaco, L, Giuliani, D, Gotuzzo, I, Magni, S, Di Martino, G, Delle Marchette, M, Guerra, L, Landoni, F, Fruscio, R, Messa, C, De Bernardi, E, Crivellaro, Cinzia, Landoni, Claudio, Elisei, Federica, Buda, Alessandro, Bonacina, Manuela, Grassi, Tommaso, Monaco, Lavinia, Giuliani, Daniela, Gotuzzo, Irene, Magni, Sonia, Di Martino, Giampaolo, Delle Marchette, Martina, Guerra, Luca, Landoni, Fabio, Fruscio, Robert, Messa, Cristina, De Bernardi, Elisabetta, Crivellaro, C, Landoni, C, Elisei, F, Buda, A, Bonacina, M, Grassi, T, Monaco, L, Giuliani, D, Gotuzzo, I, Magni, S, Di Martino, G, Delle Marchette, M, Guerra, L, Landoni, F, Fruscio, R, Messa, C, De Bernardi, E, Crivellaro, Cinzia, Landoni, Claudio, Elisei, Federica, Buda, Alessandro, Bonacina, Manuela, Grassi, Tommaso, Monaco, Lavinia, Giuliani, Daniela, Gotuzzo, Irene, Magni, Sonia, Di Martino, Giampaolo, Delle Marchette, Martina, Guerra, Luca, Landoni, Fabio, Fruscio, Robert, Messa, Cristina, and De Bernardi, Elisabetta

Abstract

Objective To evaluate the combination of positron emission tomography/computed tomography (PET/CT) and sentinel lymph node (SLN) biopsy in women with apparent early-stage endometrial carcinoma. The correlation between radiomics features extracted from PET images of the primary tumor and the presence of nodal metastases was also analyzed. Methods From November 2006 to March 2019, 167 patients with endometrial cancer were included. All women underwent PET/CT and surgical staging: 60/167 underwent systematic lymphadenectomy (Group 1) while, more recently, 107/167 underwent SLN biopsy (Group 2) with technetium-99m +blue dye or indocyanine green. Histology was used as standard reference. PET endometrial lesions were segmented (n=98); 167 radiomics features were computed inside tumor contours using standard Image Biomarker Standardization Initiative (IBSI) methods. Radiomics features associated with lymph node metastases were identified (Mann-Whitney test) in the training group (A); receiver operating characteristic (ROC) curves, area under the curve (AUC) values were computed and optimal cut-off (Youden index) were assessed in the test group (B). Results In Group 1, eight patients had nodal metastases (13%): Seven correctly ridentified by PET/CT true-positive with one false-negative case. In Group 2, 27 patients (25%) had nodal metastases: 13 true-positive and 14 false-negative. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of PET/CT for pelvic nodal metastases were 87%, 94%, 93%, 70%, and 98% in Group 1 and 48%, 97%, 85%, 87%, and 85% in Group 2, respectively. On radiomics analysis a significant association was found between the presence of lymph node metastases and 64 features. Volume-density, a measurement of shape irregularity, was the most predictive feature (p=0001, AUC=0,77, cut-off 0.35). When t esting cut-off in Group B to discriminate metastatic tumors, PET false-negative findings were reduced from 14 to 8 (-43%).

Published
2020

11. 68Ga-PSMA and 68Ga-DOTATOC PET/CT imaging mismatch of primary pancreatic adenocarcinoma in prostate cancer patient.

Author

Bonacina, Manuela, Ghirardelli, Paolo, Setti, Lucia, Vavassori, Vittorio, and Bombardieri, Emilio

Subjects
*PROSTATE cancer patients, *COMPUTED tomography, *ADENOCARCINOMA, *ENDOSCOPIC ultrasonography, *PETS, *ENDORECTAL ultrasonography, *PANCREATIC tumors, *MAGNETIC resonance imaging, *GALLIUM, *POSITRON emission tomography, *PROSTATE-specific antigen, *PROSTATE tumors
Abstract

Then, to characterize the pancreatic lesion, SP 68 sp Ga-DOTATOC PET/CT was performed with no evidence of uptake in the pancreatic mass that, otherwise, showed intense SP 68 sp Ga-PSMA uptake. A different uptake of SP 68 sp Ga-PSMA and SP 68 sp Ga-DOTATOC PET/CT was observed in a hetero-formative hypodense pancreatic lesion (29 mm). [Extracted from the article]

Published
2022
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