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1. Development and Validation of a Scoring System to Predict Response to Obeticholic Acid in Primary Biliary Cholangitis

Author

Scaravaglio, Miki, Nofit, Eugenia, Gallo, Paolo, Galati, Giovanni, Pezzato, Francesco, Rollo, Paolo, D’Ovidio, Erica, Coco, Barbara, Tortora, Annalisa, Fiorini, Cecilia, Venere, Rosanna, Scifo, Gaetano, Cannavò, Mariarita, Feletti, Valentina, Pizzolante, Fabrizio, Giannini, Edoardo Giovanni, Cotugno, Rosa, Fanella, Silvia, Losito, Francesco, Grassi, Giuseppe, Manfredi, Giulia Francesca, Buzzanca, Valerio, Omazzi, Barbara, Casella, Silvia, Zani, Francesca, Ricci, Chiara, Bellia, Valentina, Abenavoli, Ludovico, Morelli, Olivia, Crocè, Lory Saveria, Scivetti, Paolo, Panero, Antonio, Boano, Valentina, Poggi, Guido, Gimignani, Giancarlo, Conforti, Alessandro, Frazzetto, Evelise, Rapisarda, Laura, Demma, Shrin, De Vincentis, Antonio, Ampuero, Javier, Terracciani, Francesca, D’Amato, Daphne, Gerussi, Alessio, Cristoferi, Laura, Cazzagon, Nora, Bonaiuto, Emanuela, Floreani, Annarosa, Calvaruso, Vincenza, Cadamuro, Luca, Degasperi, Elisabetta, Morgando, Anna, Vanni, Ester, Lleo, Ana, Colapietro, Francesca, Alvaro, Domenico, Castellaneta, Antonino, Labanca, Sara, Viganò, Mauro, Distefano, Marco, Pace Palitti, Valeria, De Matthaeis, Nicoletta, Marzioni, Marco, Gómez-Dominguez, Elena, Montero, Jose-Luis, Molina, Esther, Garcia-Buey, Luisa, Casado, Marta, Berenguer, Marina, Conde, Isabel, Simon, Miguel-Angel, Fuentes, Javier, Costa-Moreira, Pedro, Macedo, Guilherme, Jorquera, Francisco, Morillas, Rosa-Maria, Presa, Jose, Sousa, Jose-Manuel, Gomes, Dario, Santos, Luis, Olveira, Antonio, Hernandez-Guerra, Manuel, Aburruza, Leire, Santos, Arsenio, Carvalho, Armando, Uriz, Juan, Gutierrez, Maria-Luisa, Perez, Elia, Chessa, Luchino, Pellicelli, Adriano, Marignani, Massimo, Muratori, Luigi, Niro, Grazia Anna, Brunetto, Maurizia, Ponziani, Francesca Romana, Pompili, Maurizio, Marra, Fabio, Galli, Andrea, Mussetto, Alessandro, Alagna, Giuliano, Simone, Loredana, Bertino, Gaetano, Rosina, Floriano, Cozzolongo, Raffaele, Russello, Maurizio, Baiocchi, Leonardo, Saitta, Carlo, Terreni, Natalia, Zolfino, Teresa, Rigamonti, Cristina, Vigano, Raffaella, Cuccorese, Giuseppe, Pozzoni, Pietro, Pedone, Claudio, Grasso, Simone, Picardi, Antonio, Invernizzi, Pietro, Sacco, Rodolfo, Izzi, Antonio, Fernandez-Rodriguez, Conrado, Vespasiani-Gentilucci, Umberto, and Carbone, Marco

Published
2024
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2. Noninvasive Assessment of portal Hypertension in Patients With Primary Biliary Cholangitis is Affected by Severity of Cholestasis

Author

Calvaruso, Vincenza, Celsa, Ciro, Cristoferi, Laura, Scaravaglio, Miki, Smith, Rachel, Kaur, Senamjit, Di Maria, Gabriele, Capodicasa, Luigi, Pennisi, Grazia, Gerussi, Alessio, Nofit, Eugenia, Malinverno, Federica, Lampertico, Pietro, Cazzagon, Nora, Marzioni, Marco, Vespasiani-Gentilucci, Umberto, Colapietro, Francesca, Andreone, Pietro, De Nalda, Ana Lleo, Rigamonti, Cristina, Viganò, Mauro, Giannini, Edoardo Giovanni, Russello, Maurizio, Vanni, Ester, Cerini, Federica, Orlandini, Alessia, Brunetto, Maurizia, Niro, Grazia Anna, Vettori, Giovanni, Castellaneta, Antonino, Cardinale, Vincenzo, Alvaro, Domenico, Mega, Andrea, Palitti, Valeria Pace, Cossiga, Valentina, Morisco, Filomena, Bellanti, Federico, Baiocchi, Leonardo, Fabris, Luca, Persico, Marcello, Degasperi, Elisabetta, Labanca, Sara, Bonaiuto, Emanuela, Pezzato, Francesco, Federico, Alessandro, Petta, Salvatore, Di Marco, Vito, Mells, George F., Culver, Emma, Invernizzi, Pietro, Cammà, Calogero, and Carbone, Marco

Published
2024
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5. THU-117-YI The course of radiological features and liver stiffness measurement during long-term treatment with fibrates and UDCA in patients with Primary Sclerosing Cholangitis

Author

Catanzaro, Elisa, primary, Peviani, Matteo, additional, Pezzato, Francesco, additional, Bonaiuto, Emanuela, additional, Rollo, Paolo, additional, Perin, Nicola, additional, Gambato, Martina, additional, Floreani, Annarosa, additional, Motta, Raffaella, additional, and Cazzagon, Nora, additional

Published
2024
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6. Development and validation of a scoring system to predict response to obeticholic acid in primary biliary cholangitis.

Author

De Vincentis, Antonio, primary, Ampuero, Javier, additional, Terracciani, Francesca, additional, D’Amato, Daphne, additional, Gerussi, Alessio, additional, Cristoferi, Laura, additional, Cazzagon, Nora, additional, Bonaiuto, Emanuela, additional, Floreani, Annarosa, additional, Calvaruso, Vincenza, additional, Cadamuro, Luca, additional, Degasperi, Elisabetta, additional, Morgando, Anna, additional, Vanni, Ester, additional, Lleo, Ana, additional, Colapietro, Francesca, additional, Alvaro, Domenico, additional, Castellaneta, Antonino, additional, Labanca, Sara, additional, Viganò, Mauro, additional, Distefano, Marco, additional, Palitti, Valeria Pace, additional, Ricci, Chiara, additional, De Matthaeis, Nicoletta, additional, Marzioni, Marco, additional, Gómez-Dominguez, Elena, additional, Montero, Jose-Luis, additional, Molina, Esther, additional, Garcia-Buey, Luisa, additional, Casado, Marta, additional, Berenguer, Marina, additional, Conde, Isabel, additional, Simon, Miguel-Angel, additional, Fuentes, Javier, additional, Costa-Moreira, Pedro, additional, Macedo, Guilherme, additional, Jorquera, Francisco, additional, Morillas, Rosa-Maria, additional, Presa, Jose, additional, Sousa, Jose-Manuel, additional, Gomes, Dario, additional, Santos, Luis, additional, Olveira, Antonio, additional, Hernandez-Guerra, Manuel, additional, Aburruza, Leire, additional, Santos, Arsenio, additional, Carvalho, Armando, additional, Uriz, Juan, additional, Gutierrez, Maria-Luisa, additional, Perez, Elia, additional, Chessa, Luchino, additional, Pellicelli, Adriano, additional, Marignani, Massimo, additional, Muratori, Luigi, additional, Niro, Grazia Anna, additional, Brunetto, Maurizia, additional, Ponziani, Francesca Romana, additional, Pompili, Maurizio, additional, Marra, Fabio, additional, Galli, Andrea, additional, Mussetto, Alessandro, additional, Alagna, Giuliano, additional, Simone, Loredana, additional, Bertino, Gaetano, additional, Rosina, Floriano, additional, Cozzolongo, Raffaele, additional, Russello, Maurizio, additional, Baiocchi, Leonardo, additional, Saitta, Carlo, additional, Terreni, Natalia, additional, Zolfino, Teresa, additional, Rigamonti, Cristina, additional, Vigano, Raffaella, additional, Cuccorese, Giuseppe, additional, Pozzoni, Pietro, additional, Pedone, Claudio, additional, Grasso, Simone, additional, Picardi, Antonio, additional, Invernizzi, Pietro, additional, Sacco, Rodolfo, additional, Izzi, Antonio, additional, Fernandez-Rodriguez, Conrado, additional, Vespasiani-Gentilucci, Umberto, additional, and Carbone, Marco, additional

Published
2024
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9. Serum Vascular Adhesion Protein-1 and Endothelial Dysfunction in Hepatic Cirrhosis: Searching for New Prognostic Markers.

Author

Fasolato, Silvano, Bonaiuto, Emanuela, Rossetto, Monica, Vanzani, Paola, Ceccato, Fabio, Vittadello, Fabio, Zennaro, Lucio, Rigo, Adelio, Mammano, Enzo, Angeli, Paolo, Pontisso, Patrizia, and Di Paolo, Maria Luisa

Subjects
*PROGNOSIS, *ENDOTHELIAL cells, *VASCULAR cell adhesion molecule-1, *ENDOTHELIUM diseases, *CIRRHOSIS of the liver, *CD54 antigen
Abstract

Endothelial dysfunction plays a key role in the development of liver cirrhosis. Among the biomarkers of endothelial dysfunction, the soluble form of Vascular Adhesion Protein-1 (sVAP-1) is an unconventional and less known adhesion molecule endowed also with amine oxidase activity. The aim of this study was to explore and correlate the behavior of sVAP-1 with that of the soluble vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) and with the severity of liver cirrhosis. A cross-sectional study was carried out by enrolling 28 controls, 59 cirrhotic patients without hepatocellular carcinoma, and 56 patients with hepatocellular carcinoma (HCC), mainly caused by alcohol abuse. The levels of adhesion molecules and of the pro-inflammatory cytokines (IL-6 and TNF-αα) were determined by immunoassay and the enzymatic activity of sVAP-1 by a fluorometric assay. In non-diabetic patients without HCC, a specific behavior of sVAP-1 was highlighted. Differently from sVCAM-1, sICAM-1, and cytokines, the sVAP-1 level was significantly increased only in the early stage of disease, and then, it decreased in the last stage (866 ± 390 ng/mL vs. 545 ± 316 ng/mL, in Child–Pugh class A vs. C, respectively, p < 0.05). Bivariate analysis correlates sVAP-1 to sVCAM-1, in the absence of HCC (Spearman's rho = 0.403, p < 0.01). Multiple linear regression analysis revealed that sVCAM-1 appears to be a predictor of sVAP-1 (β coefficient = 0.374, p = 0.021). In conclusion, in non-diabetic and non-HCC cirrhotic patients, sVAP-1 may be a potential prognostic biomarker that, together with sVCAM-1 and pro-inflammatory cytokines, may provide information on the progression of sinusoidal liver endothelium damage. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Celiac disease in patients with autoimmune hepatitis is associated with a milder liver disease course and a better chance of immunosuppressive treatment withdrawal

Author

Pezzato, Francesco, primary, D’Ovidio, Erica, additional, Perini, Lisa, additional, Bonaiuto, Emanuela, additional, Rollo, Paolo, additional, Russo, Francesco Paolo, additional, D’Odorico, Anna, additional, Zingone, Fabiana, additional, Floreani, Annarosa, additional, and Cazzagon, Nora, additional

Published
2023
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22. Abstracts presented at the 14th International Congress on Amino Acids, Peptides and Proteins

Author

Jacubek Petr, Vianello Fabio, Macone Alberto, Tucek Jiri, Zboril Radek, Miotto Giovanni, Baratella Davide, Magro Massimiliano, Agostinelli Enzo, Sconcerle Elisabetta, Bonaiuto Emanuela, and Terzo Milo

Subjects
Amine oxidase, Chromate conversion coating, biology, Organic Chemistry, Clinical Biochemistry, Electrocatalyst, Biochemistry, chemistry.chemical_compound, chemistry, biology.protein, Organic chemistry, Bovine serum albumin, Polyamine, Biosensor, Iron oxide nanoparticles, Nuclear chemistry
Published
2015
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23. Stealth Iron Oxide Nanoparticles for Organotropic Drug Targeting

Author

Magro, Massimiliano, primary, Baratella, Davide, additional, Bonaiuto, Emanuela, additional, de Almeida Roger, Jessica, additional, Chemello, Giulia, additional, Pasquaroli, Sonia, additional, Mancini, Leonardo, additional, Olivotto, Ike, additional, Zoppellaro, Giorgio, additional, Ugolotti, Juri, additional, Aparicio, Claudia, additional, Fifi, Anna P., additional, Cozza, Giorgio, additional, Miotto, Giovanni, additional, Radaelli, Giuseppe, additional, Bertotto, Daniela, additional, Zboril, Radek, additional, and Vianello, Fabio, additional

Published
2019
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30. Bovine serum amine oxidase and chromate-modified iron oxide nanoparticles for polyamine biosensing

Author

Magro, Massimiliano, Bonaiuto, Emanuela, Baratella, Davide, Elisabetta, Sconcerle, Milo, Terzo, Petr, Jacubek, Miotto, Giovanni, Alberto, Macone, Enzo, Agostinelli, Jiri, Tucek, Radek, Zboril, and Vianello, Fabio

Subjects
Bovine serum amine oxidase, Bichromate, Fe2O3, Hybrid nanomaterial, Electrocatalysis, Bovine serum amine oxidase, Bichromate, Polyamine biosensor, Fe2O3, Polyamine biosensor, Electrocatalysis, Hybrid nanomaterial
Published
2015

31. Oxytetracycline Delivery in Adult Female Zebrafish by Iron Oxide Nanoparticles

Author

Chemello, Giulia, primary, Piccinetti, Chiara, additional, Randazzo, Basilio, additional, Carnevali, Oliana, additional, Maradonna, Francesca, additional, Magro, Massimiliano, additional, Bonaiuto, Emanuela, additional, Vianello, Fabio, additional, Radaelli, Giuseppe, additional, Fifi, Anna Paola, additional, Gigliotti, Federica, additional, and Olivotto, Ike, additional

Published
2016
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32. Back Cover: Electrocatalytic Nanostructured Ferric Tannates: Characterization and Application of a Polyphenol Nanosensor (ChemPhysChem 20/2016)

Author

Magro, Massimiliano, primary, Bonaiuto, Emanuela, additional, Baratella, Davide, additional, de Almeida Roger, Jessica, additional, Jakubec, Petr, additional, Corraducci, Vittorino, additional, Tuček, Jiri, additional, Malina, Ondrej, additional, Zbořil, Radek, additional, and Vianello, Fabio, additional

Published
2016
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34. Colloidal Surface Active Maghemite Nanoparticles for Biologically Safe CrVI Remediation: from Core-Shell Nanostructures to Pilot Plant Development

Author

Magro, Massimiliano, primary, Domeneghetti, Stefania, additional, Baratella, Davide, additional, Jakubec, Petr, additional, Salviulo, Gabriella, additional, Bonaiuto, Emanuela, additional, Venier, Paola, additional, Malina, Ondřej, additional, Tuček, Jiří, additional, Ranc, Václav, additional, Zoppellaro, Giorgio, additional, Zbořil, Radek, additional, and Vianello, Fabio, additional

Published
2016
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35. Citrinin mycotoxin recognition and removal by naked magnetic nanoparticles

Author

Magro, Massimiliano, primary, Moritz, Denise Esteves, additional, Bonaiuto, Emanuela, additional, Baratella, Davide, additional, Terzo, Milo, additional, Jakubec, Petr, additional, Malina, Ondřej, additional, Čépe, Klára, additional, Aragao, Glaucia Maria Falcao de, additional, Zboril, Radek, additional, and Vianello, Fabio, additional

Published
2016
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36. Back Cover: Ternary Hybrid γ‐Fe2O3/CrVI/Amine Oxidase Nanostructure for Electrochemical Sensing: Application for Polyamine Detection in Tumor Tissue (Chem. Eur. J. 20/2016)

Author

Bonaiuto, Emanuela, primary, Magro, Massimiliano, additional, Baratella, Davide, additional, Jakubec, Petr, additional, Sconcerle, Elisabetta, additional, Terzo, Milo, additional, Miotto, Giovanni, additional, Macone, Alberto, additional, Agostinelli, Enzo, additional, Fasolato, Silvano, additional, Venerando, Rina, additional, Salviulo, Gabriella, additional, Malina, Ondrej, additional, Zboril, Radek, additional, and Vianello, Fabio, additional

Published
2016
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37. Ternary Hybrid γ‐Fe2O3/CrVI/Amine Oxidase Nanostructure for Electrochemical Sensing: Application for Polyamine Detection in Tumor Tissue

Author

Bonaiuto, Emanuela, primary, Magro, Massimiliano, additional, Baratella, Davide, additional, Jakubec, Petr, additional, Sconcerle, Elisabetta, additional, Terzo, Milo, additional, Miotto, Giovanni, additional, Macone, Alberto, additional, Agostinelli, Enzo, additional, Fasolato, Silvano, additional, Venerando, Rina, additional, Salviulo, Gabriella, additional, Malina, Ondrej, additional, Zboril, Radek, additional, and Vianello, Fabio, additional

Published
2016
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41. Interaction between new polyamine analogs and bovine serum amine oxidase

Author

Tempera, G., Minarini, A., Milelli, A., Tumiatti, V., Ueshima, T., Merignolo, M., Bonaiuto, Emanuela, DI PAOLO, MARIA LUISA, Toninello, Antonio, Ragno, R., Ballante, F., Stevanato, R., and Agostinelli, E.

Subjects
polyamines, structure-function studies, Anticancer drug
Published
2012

43. Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study

Author

Anna Minarini, Maurizio Pegoraro, Vincenzo Tumiatti, Maria Luisa Di Paolo, Valeria Rizzoli, Michele Lunelli, Bonaiuto Emanuela, Andrea Milelli, Bonaiuto E., Minarini A., Tumiatti V., Milelli A., Lunelli M., Pegoraro M., Rizzoli V., and Di Paolo ML.

Subjects
Spectrometry, Mass, Electrospray Ionization, Amine oxidase, Magnetic Resonance Spectroscopy, Stereochemistry, SEMICARBAZIDE, Clinical Biochemistry, monoamine oxidases, Biochemistry, Cofactor, SYNTHETIC POLYAMINES, chemistry.chemical_compound, inhibitors, Polyamines, Enzyme Inhibitors, Monoamine Oxidase, Protein secondary structure, chemistry.chemical_classification, biology, Chemistry, Circular Dichroism, Organic Chemistry, SEMICARBAZIDESENSITIVE AMINE OXIDASES, Active site, semicarbazide-sensitive amine oxidase, synthetic polyamines, structure-function studies, MONOAMINE OXIDASE B, Kinetics, Enzyme, AMINE OXIDASE INHIBITORS, biology.protein, Amine gas treating, Amine Oxidase (Copper-Containing), Monoamine oxidase B, Polyamine
Abstract

In the last few decades, medicinal chemists have carried out extensive research on synthetic polyamines for use as anticancer drugs and multitarget-directed ligands in neurodegenerative diseases. The aim of this study was to evaluate the effect of some synthetic polyamines as inhibitors of two new potential targets, human semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) and monoamine oxidases B (MAO B), enzymes involved in various multi-factorial diseases such as Alzheimer's disease. N,N'-Dibenzyl-dodecane-1,12-diamine (Bis-Bza-Diado), a newly synthesised compound, and ELP 12, a muscarinic cholinergic M(2) receptor antagonist, were found to behave as reversible and mixed non-competitive inhibitors of both amine oxidases (dissociation constants of about 100 microM). ELP 12 was found to be more selective for SSAO/VAP-1. Combining kinetic and structural approaches, the binding mode of ELP 12 to SSAO/VAP-1 was investigated. ELP 12 may bind at the entrance of the active site channel by ionic interactions with ASP446 and/or ASP180; one end of the polyamine may be accommodated inside the channel, reaching the TPQ cofactor area. The binding of ELP 12 induces rearrangement of the secondary structure of the enzyme and impedes substrate entry and/or product release and catalysis. These structural data reveal that the entrance and the first part of the SSAO/VAP-1 channel may be considered as a new target area, or a "secondary binding site", for modulators of human SSAO/VAP-1 activity. These results indicate ELP 12 and Bis-Bza-Diado as new "skeletons" for the development of novel SSAO/VAP-1 and MAO B inhibitors.

Published
2012

44. Magnetic Nanoparticles with Covalently Bound Self-Assembled Protein Corona for Advanced Biomedical Applications

Author

Venerando, Rina, Miotto, Giovanni, Magro, Massimiliano, Dallan, Marco, Baratella, Davide, Bonaiuto, Emanuela, Zboril, Radek, and Vianello, Fabio

Abstract

Novel surface active maghemite nanoparticles (SAMNs) possessing peculiar colloidal properties and surface characteristics are able to covalently bind biomolecules. The interactions of SAMNs and rhodamine derivatized SAMNs (SAMN@RITC) with proteins from cell culture medium were studied by gel electrophoresis and mass spectrometry. Among the 3000 proteins present in fetal calf serum, SAMNs and SAMN@RITC give rise to the formation of a self-assembled corona shell with 22 selected proteins, representing minor plasma proteins, among which α-2-HS- glycoprotein stands out. Bovine serum albumin (BSA), representing 80% of the total serum proteins, shows negligible absorption on the SAMN surface. Nevertheless, SAMNs are able to bind BSA, upon incubation in pure BSA solutions. The interaction between SAMNs and BSA was investigated by optical spectroscopy, circular dichroism, Fourier transform infrared spectroscopy, and transmission electron microscopy. BSA binding resulted a time-consuming process, nevertheless experimental results showed the interaction of 6 ± 2 BSA molecules per nanoparticle, and optical spectra indicate remarkable changes in SAMN optical features, as well as circular dichroism proved secondary structure alteration of bound BSA, suggesting that the protein needs to adapt its structure to adhere to nanoparticle surface. The selectively bound protein corona shell, formed upon SAMNs incubation in calf serum, was responsible for the characteristic behavior when SAMNs were tested for cell internalization and cytotoxicity on HeLa cells. Cytotoxicity of SAMN preparations was extensively studied, and was negligible up to 100 μg mL–1. Moreover, nanoparticle uptake proceeded for long times, suggesting a correlation between internalization and stability of covalently bound self-assembled protein corona, representing a unique example of magnetic nanoparticle opsonization via covalent binding. We suggest that SAMN based nanobiocomposites can be employed for the preparation of self-assembled opsonized nanoparticles as future candidates for biomedical applications.

Published
2024
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46. Alkaline Water and Longevity: A Murine Study

Author

Magro, Massimiliano, primary, Corain, Livio, additional, Ferro, Silvia, additional, Baratella, Davide, additional, Bonaiuto, Emanuela, additional, Terzo, Milo, additional, Corraducci, Vittorino, additional, Salmaso, Luigi, additional, and Vianello, Fabio, additional

Published
2016
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