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26 results on '"Bondu, Magalie"'

3. Supercontinuum sources in the practice of multimodal imaging

Author

Bondu, Magalie Melanie Lea and Podoleanu, Adrian

Subjects
500, Q Science
Abstract

The development of recent imaging modalities and of multimodal imaging may offer new perspectives for biomedical imaging, such as in-vivo cancer detection at early stages. By combining optical coherence tomography (OCT) and photoacoustic microscopy (PAM), complementary information is extracted from tissue: scattering and absorption. Non-invasive cross-sectional images with micrometre resolution are obtained. In this thesis, for the first time, encouraging results using a single SC source for OCT and PAM are obtained. Micrometre axial resolution is achieved using SC sources for OCT. The use of SC sources for PAM allows for multispectral PAM (MPAM) by using several excitation spectral bands. With MPAM, different absorbers are distinguishable and recognisable through their absorption spectra. In addition, for the first time, spectroscopic photoacoustic (sPA) measurements are demonstrated in the visible using a bandwidth narrower than 40 nm. These results were obtained with the first multimodal imaging system that combines sPA, PAM, MPAM and OCT. A single commercially available SC source is used for excitation. Diverse in-vitro and in-vivo samples are imaged to show the capabilities of such a configuration. In addition, the development of a novel fibre-based SC source with both increased energy density and pulse repetition frequency (PRF) is presented. The increased pulse energy allows reduction of excitations bands that leads to more accurate MPAM and sPA measurements, while the access to larger PRFs allows for both noise reduction and faster imaging rates in PAM and OCT. A tapered photonic crystal fibre (PCF) is used to generate the SC by nonlinear spectral broadening. The larger input core of the tapered PCF enables enhanced energy density, where more than 50-100 nJ is achieved with less than 30 nm wide bandwidth, over a broad spectrum extending from 500 nm to 1700 nm. Such a source can be used for in-vivo blood oxygen saturation determination, skin and other superficial organs imaging, which is critical to image tumours and diagnose early stage cancers. Such imaging modalities can also be beneficial during surgery and treatment.

Published
2018
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10. High-pulse energy supercontinuum sources for multi-spectral photoacoustic imaging in the near-infrared wavelength region (Conference Presentation)

Author

Dasa, Manoj Kumar, primary, Kwarkye, Kyei, additional, Nteroli, Gianni, additional, Efunbajo, Oyewole Benjamin, additional, Bondu, Magalie, additional, Woyessa, Getinet, additional, Israelsen, Niels M., additional, Bradu, Adrian, additional, Petersen, Christian R., additional, Moselund, Peter M., additional, Bowen, Patrick, additional, Markos, Christos, additional, and Bang, Ole, additional

Published
2020
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12. Supercontinuum Applications in High Resolution Non-Invasive Optical Imaging

Author

Podoleanu, Adrian, primary, Bang, Ole, additional, Barh, Ajanta, additional, Bojesen, Sophie, additional, Bondu, Magalie, additional, Bradu, Adrian, additional, Caujolle, Sophie, additional, Chin, Catherine, additional, Denninger, Mark, additional, Feuchter, Thomas, additional, Fleischhauer, Felix, additional, Hadersdal, Merete, additional, Hannesschlager, Gunther, additional, Israelsen, Niels Moller, additional, Jain, Deepak, additional, Jensen, Mikkel, additional, Gonzalo, Ivan B., additional, Maria, Michael, additional, Marques, Manuel, additional, Leick, Lasse, additional, Tidemand-Lichtenberg, Peter, additional, Mogensen, Mette, additional, Moselund, Peter M., additional, Pedersen, Christian, additional, and Petersen, Christian R., additional

Published
2019
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15. Supercontinuum applications in high resolution non invasive optical imaging

Author

Podoleanu, Adrian, primary, Bang, Ole, additional, Bojesen, Sophie, additional, Bondu, Magalie, additional, Bradu, Adrian, additional, Caujolle, Sophie, additional, Chin, Catherine, additional, Denninger, Mark, additional, Feuchter, Thomas, additional, Fleischhauer, Felix, additional, Hædersdal, Merete, additional, Israelsen, Niels Møller, additional, Jensen, Mikkel, additional, Gonzalo, Ivan B., additional, Maria, Michael, additional, Marques, Manuel, additional, Leick, Lasse, additional, Mogensen, Mette, additional, and Moselund, Peter M., additional

Published
2018
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26. Theory and experiment of transient two-wave mixing in Yb-doped single-frequency fiber amplifiers induced by frequency modulation.

Author

Hauge JM, Pedersen JE, Bondu M, Papior SR, and Lægsgaard J

Abstract

This paper presents a theoretical and experimental characterization of an instability phenomenon observed in single-frequency fiber amplifiers when the frequency of the seed laser is modulated. The instability manifests itself as fluctuating elastic back-reflections that occur only when the frequency is decreasing with time. The theory is a generalization of a coupled-mode model developed for a single-frequency fiber amplifier back-seeded with a constant frequency shift relative to the main signal. It can explain most observed features of the experiments in a qualitative and semi-quantitative way. Open questions and directions for further developments are also discussed.

Published
2024
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