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8. One-Day-Old Embryo

Author

Bernardini, G., Prati, M., Bonetti, E., Scarì, G., Bernardini, G., Prati, M., Bonetti, E., and Scarì, G.

Published
1999
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9. Two-Day-Old Larva

Author

Bernardini, G., Prati, M., Bonetti, E., Scarì, G., Bernardini, G., Prati, M., Bonetti, E., and Scarì, G.

Published
1999
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10. Neurulation

Author

Bernardini, G., Prati, M., Bonetti, E., Scarì, G., Bernardini, G., Prati, M., Bonetti, E., and Scarì, G.

Published
1999
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11. Five-Day-Old Larva

Author

Bernardini, G., Prati, M., Bonetti, E., Scarì, G., Bernardini, G., Prati, M., Bonetti, E., and Scarì, G.

Published
1999
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12. Cleavage

Author

Bernardini, G., Prati, M., Bonetti, E., Scarì, G., Bernardini, G., Prati, M., Bonetti, E., and Scarì, G.

Published
1999
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13. Xenopus Gametes

Author

Bernardini, G., Prati, M., Bonetti, E., Scarì, G., Bernardini, G., Prati, M., Bonetti, E., and Scarì, G.

Published
1999
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14. Fertilization

Author

Bernardini, G., Prati, M., Bonetti, E., Scarì, G., Bernardini, G., Prati, M., Bonetti, E., and Scarì, G.

Published
1999
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22. Organogenesis

Author

Bernardini, G., Prati, M., Bonetti, E., Scarì, G., Bernardini, G., Prati, M., Bonetti, E., and Scarì, G.

Published
1999
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23. Gastrulation

Author

Bernardini, G., Prati, M., Bonetti, E., Scarì, G., Bernardini, G., Prati, M., Bonetti, E., and Scarì, G.

Published
1999
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24. Addressing the impact of SARS-CoV-2 infection in persons with congenital bleeding disorders: The Italian MECCOVID-19 study

Author

Coluccia A., Marchesini E., Giuffrida A. C., Rivolta G. F., Ricca I., Zanon E., Luciani M., De Cristofaro R., Coppola A., Rocino A., Ambaglio C., Borchiellini A., Bonetti E., Caimi T. M., Carulli C., Contino L., Cultrera D., D'Attilio E., Delios G., Feola G., Giordano P., Giuffrida G., Grandone E., Lassandro G., Linari S., Margaglione M., Marino R., Molinari A. C., Napolitano M., Nichele I., Notarangelo L. D., Pasca S., Piscitelli L., Pollio B., Quintavalle G., Radossi P., Santoro C., Santoro R. C., Schiavulli M., Sottilotta G., Speciale V., Tagliaferri A., Valdre L., Coluccia A., Marchesini E., Giuffrida A.C., Rivolta G.F., Ricca I., Zanon E., Luciani M., De Cristofaro R., Coppola A., Rocino A., Ambaglio C., Borchiellini A., Bonetti E., Caimi T.M., Carulli C., Contino L., Cultrera D., D'Attilio E., Delios G., Feola G., Giordano P., Giuffrida G., Grandone E., Lassandro G., Linari S., Margaglione M., Marino R., Molinari A.C., Napolitano M., Nichele I., Notarangelo L.D., Pasca S., Piscitelli L., Pollio B., Quintavalle G., Radossi P., Santoro C., Santoro R.C., Schiavulli M., Sottilotta G., Speciale V., Tagliaferri A., and Valdre L.

Subjects
Adult, Inherited, Male, Pediatrics, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), congenital bleeding disorders, congenital bleeding disorder, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), haemophilia, Hemorrhage, Haemophilia, Letter to the Editors, SARS‐CoV‐2, Young Adult, Blood Coagulation Disorders, Inherited, COVID‐19, COVID-19, epidemiology, observational study, SARS-CoV-2, Aged, Child, Preschool, Disease Management, Female, Humans, Italy, Middle Aged, Epidemiology, medicine, Young adult, Disease management (health), Child, Preschool, Letter to the Editor, Genetics (clinical), business.industry, Hematology, General Medicine, Blood Coagulation Disorders, medicine.disease, Observational study, business
Abstract

congenital bleeding disorders

Published
2021

25. Functional and genetic aberrations of in vitro-cultured marrow-derived mesenchymal stromal cells of patients with classical Philadelphia-negative myeloproliferative neoplasms

Author

Avanzini, M A, Bernardo, M E, Novara, F, Mantelli, M, Poletto, V, Villani, L, Lenta, E, Ingo, D M, Achille, V, Bonetti, E, Massa, M, Campanelli, R, Fois, G, Catarsi, P, Gale, R P, Moretta, A, Aronica, A, Maccario, R, Acquafredda, G, Lisini, D, Zecca, M, Zuffardi, O, Locatelli, F, Barosi, G, and Rosti, V

Published
2014
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28. New data from the italian national register of congenital coagulopathies, 2016 annual survey

Author

Abbonizio F., Hassan H. J., Riccioni R., Santagostino E., Arcieri R., Giampaolo A., Contino L., Accorsi A., Caremani A., Ettorre P. C., Giordano P., Lassandro G., Valdre L., Notarangelo L., Aru A. B., Radossi P., Tagariello G., Cultrera D., Iannaccaro P., Santoro R., Biasoli C., Di Gregorio P., Daniele F., Testa S., Serino M. L., Castaman G., Linari S. S., Morfini M., Molinari A. C., Delios G., Cantori I., Franchini M., Caimi M. T., Mancuso M. E., Peyvandi F., Marietta M., Todisco A., Speciale V., Cerbone A. M., Di Minno G., Schiavulli M., Rocino A., Spiezia M. M., Zanon E., Gagliano F., Mansueto M. F., Siragusa S., Coppola A., Quintavalle G., Rivolta G. F., Tagliaferri A., Ambaglio C., Gamba G., Marchesini E., Oliovecchio E., Dragani A., Arbasi M. C., MacChi S., Vincenzi D., Sottilotta G., Pizzini A. M., Luciani M., De Cristofaro R., Baldacci E., Mazzucconi M. G., Santoro C., Mameli L. A., Coluccia A., Marino P., Borchiellini A., Schinco P. C., Messina M., Pollio B., Ricca I., Agostini P., Cristallo A. F., Barillari G., De Angelis V., Mosanghini M. E., Feola G., Bonetti E., Cesaro S., Gandini G., Giuffrida A., Tosetto A., Abbonizio, F., Hassan, H. J., Riccioni, R., Santagostino, E., Arcieri, R., Giampaolo, A., Contino, L., Accorsi, A., Caremani, A., Ettorre, P. C., Giordano, P., Lassandro, G., Valdre, L., Notarangelo, L., Aru, A. B., Radossi, P., Tagariello, G., Cultrera, D., Iannaccaro, P., Santoro, R., Biasoli, C., Di Gregorio, P., Daniele, F., Testa, S., Serino, M. L., Castaman, G., Linari, S. S., Morfini, M., Molinari, A. C., Delios, G., Cantori, I., Franchini, M., Caimi, M. T., Mancuso, M. E., Peyvandi, F., Marietta, M., Todisco, A., Speciale, V., Cerbone, A. M., Di Minno, G., Schiavulli, M., Rocino, A., Spiezia, M. M., Zanon, E., Gagliano, F., Mansueto, M. F., Siragusa, S., Coppola, A., Quintavalle, G., Rivolta, G. F., Tagliaferri, A., Ambaglio, C., Gamba, G., Marchesini, E., Oliovecchio, E., Dragani, A., Arbasi, M. C., Macchi, S., Vincenzi, D., Sottilotta, G., Pizzini, A. M., Luciani, M., De Cristofaro, R., Baldacci, E., Mazzucconi, M. G., Santoro, C., Mameli, L. A., Coluccia, A., Marino, P., Borchiellini, A., Schinco, P. C., Messina, M., Pollio, B., Ricca, I., Agostini, P., Cristallo, A. F., Barillari, G., De Angelis, V., Mosanghini, M. E., Feola, G., Bonetti, E., Cesaro, S., Gandini, G., Giuffrida, A., and Tosetto, A.

Subjects
Blood coagulation disorder, Haemophilia B, Haemophilia A, Von Willebrand's disease, Register
Abstract

Background - In Italy, the National Register of Congenital Coagulopathies (NRCC) collects epidemiological and therapeutic data from patients affected by haemophilia A (HA), haemophilia B (HB), von Willebrand's disease (vWD) and other rare coagulation disorders. Here we present data from the 2016 annual survey. Materials and methods - Data are provided by the Italian Haemophilia Centres, on a voluntary basis. Information flows from every Centre to a web-based platform of the Italian Association of Haemophilia Centres, shared with the Italian National Institute of Health, in accordance with current privacy laws. Patients are classified by diagnosis, disease severity, age, gender and treatment-related complications. Results - In 2016, the total number of patients with congenital coagulopathies in the NRCC was 10,360: 39.8% of these patients had HA, 31.5% had vWD, 8.5% had HB, and 20.2% had less common factor deficiencies. The overall prevalence of HA and HB was 13.9/100,000 males and 3.0/100,000 males, respectively. The overall prevalence of vWD was 5.4/100,000 inhabitants. During 2016, 126 patients had current alloantibodies to factor VIII (FVIII) or factor IX (FIX) and were under treatment with bypassing agents and/or immune tolerance induction. Overall, 388 patients with a history of alloantibodies were recorded in the NRCC of whom 337 with severe HA and 12 with severe HB. Coagulation factor use, evaluated from treatment plans, was approximately 451,000,000 IU of FVIII for HA patients (7.5 IU/inhabitant), and approximately 53,000,000 IU of FIX for HB patients (0.9 IU/inhabitant). Discussion - The prevalences of HA and HB fall within the ranges reported in more developed countries; the consumption of FVIII and FIX was in line with that of other European countries (France, United Kingdom) and Canada. The NRCC, with its bleeding disorder dataset, is a helpful tool for shaping public health policies, as well as planning clinical and epidemiological research projects.

Published
2020

33. Investire nelle donne: un'opportunità da sviluppare all'interno del Recovery Plan

Author

Pini A., Bonetti E., Brancaccio S., Farina D., Poggio B., and Polimeni A.

Subjects
pari opportunità, parità di genere, Recovery Plan
Abstract

TAVOLA ROTONDA - L'argomento della Tavola Rotonda è di grande attualità poiché all'interno del Recovery Plan vi sono fondi specifici destinati alla parità di genere e alla coesione, e il loro opportuno indirizzo potrà contribuire a un cambiamento sostanziale della grave situazione generata dalla pandemia e che ha colpito in particolare le donne. E un tema che coinvolge il mondo della formazione, della ricerca, delle imprese, delle politiche sociali e il CPO-SIF qui propone una discussione tra le varie parti in un tavolo di eccellenza al femminile, per confrontarsi e ripartire investendo nelle donne.

Published
2021

36. HbS/β+ thalassemia: Really a mild disease? A National survey from the AIEOP Sickle Cell Disease Study Group with genotype-phenotype correlation

Author

Notarangelo, L. D., Agostini, A., Casale, M., Samperi, P., Arcioni, F., Gorello, P., Perrotta, S., Masera, N., Barone, A., Bertoni, E., Bonetti, E., Burnelli, R., Casini, T., Del, Vecchio, Filippini, G. C., Giona, B., Giordano, F., Gorio, P., Marchina, C., Nardi, E., Petrone, M., Colombatti, A., Sainati, R., Russo, L. r., Email Author View Correspondence (jump link), G., Notarangelo, L. D., Agostini, A., Casale, M., Samperi, P., Arcioni, F., Gorello, P., Perrotta, S., Masera, N., Barone, A., Bertoni, E., Bonetti, E., Burnelli, R., Casini, T., Del Vecchio, G. C., Filippini, B., Giona, F., Giordano, P., Gorio, C., Marchina, E., Nardi, M., Petrone, Angelo, Colombatti, R., Sainati, L., and Russo, G.

Subjects
Male, Thalassemia, Hemoglobin, Sickle, HbS/β+ thalassemia, Italy, Sickle cell disease, children, genotype, phenotype, Avascular necrosis, Disease, beta-Globins, Gastroenterology, Sickle, 0302 clinical medicine, Genotype, Public Health Surveillance, Child, Stroke, Anemia, Hematology, General Medicine, Middle Aged, Sickle Cell, Phenotype, 030220 oncology & carcinogenesis, Child, Preschool, Cohort, Female, HbS, beta plus thalassemia, Adult, medicine.medical_specialty, Adolescent, Anemia, Sickle Cell, Sepsis, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Humans, Hemoglobin, Preschool, Alleles, Genetic Association Studies, Infant, Retrospective Studies, beta-Thalassemia, business.industry, Retrospective cohort study, medicine.disease, business, 030215 immunology
Abstract

Objectives: HbS/β+ patients’ presence in Italy increased due to immigration; these patients are clinically heterogeneous, and specific guidelines are lacking. Our aim is to describe a cohort of HbS/β+ patients, with genotype-phenotype correlation, in order to offer guidance for clinical management of such patients. Methods: Retrospective cohort study of HbS/β+ patients among 15 AIEOP Centres. Results: A total of 41 molecularly confirmed S/β+ patients were enrolled (1-55years, median 10.9) and classified on β+ mutation: IVS-I-110, IVS-I-6, promoter, and “others.” Prediagnostic events included VOC 16/41 (39%), ACS 6/41 (14.6%), sepsis 3/41 (3.7%), and avascular necrosis 3/41 (7,3%). Postdiagnostic events were VOC 22/41 (53.6% %), sepsis 4/41 (9.7%), ACS 4/41 (9.7%), avascular necrosis 3/41 (7.3%), aplastic crisis 2/41 (4.8%), stroke 1/41 (2.4%), ACS 1/41 (2.4%), and skin ulcerations 1/41 (2.4%). The IVS-I-110 group presented the lowest median age at first SCD-related event (P=.02 vs promoter group) and the higher median number of severe events/year (0.26 events/patient/year) (P=.01 vs IVS-I-6 and promoter groups). Promoter group presented a specific skeletal phenotype. Treatment regimen applied was variable among the centers. Conclusions: HbS/β+ is not always a mild disease. Patients with IVS-I-110 mutation could benefit from a standard of care like SS and S/β° patients. Standardization of treatment is needed.

Published
2019

37. Consensus statements on vaccination in patients with haemophilia—Results from the Italian haemophilia and vaccinations (HEVA) project

Author

Santagostino E., Riva A., Cesaro S., Esposito S., Matino D., Mazzucchelli R. I., Molinari, Angelo Claudio, Mura R., Notarangelo L. D., Tagliaferri A., Di Minno G., Clerici M., Ambaglio C., Brigida Aru A., Baldacci E., Barillari G., Basso M., Bernasconi S., Bertamino M., Bertoni E., Biasoli C., Federica Biguzzi E., Bonetti E., Borchiellini A., Bulgarelli S., Cabibbo S., Cantori I., Castaman G., Castiglia P., Coluccia A., Coppetelli U., Coppola A., Cultrera D., De Candia E., Delios G., Di Gennaro L., Di Gregorio P., Di Minno M., Dragani A., Pietro Ettorre C., Franchini M., Galli M., Gallo G., Giordano P., Giuffrida G., Iannaccaro P., Lassandro G., Lazzareschi I., Linari S., Luciani M., Macchi S., Malcangi G., Malizia R., Marietta M., Marino R., Massoud M., Gabriella Mazzucconi M., Milan M., Morfini M., Napolitano M., Pasca S., Pedrazzi P., Peyvandi F. A., Piscitelli L., Pollio B., Preti P., Quintavalle G., Radossi P., Raso S., Ricca I., Rocino A., Santoro C., Carlotta Santoro R., Sarolo L., Schiavoni M., Schiavulli M., Sciancalepore P., Luisa Serino M., Mario Siragusa S., Sottilotta G., Svahn J., Valdre L., Cristina Vedovati M., Zanon E., Santagostino, E., Riva, A., Cesaro, S., Esposito, S., Matino, D., Mazzucchelli, R. I., Molinari, Angelo Claudio, Mura, R., Notarangelo, L. D., Tagliaferri, A., Di Minno, G., Clerici, M., Ambaglio, C., Brigida Aru, A., Baldacci, E., Barillari, G., Basso, M., Bernasconi, S., Bertamino, M., Bertoni, E., Biasoli, C., Federica Biguzzi, E., Bonetti, E., Borchiellini, A., Bulgarelli, S., Cabibbo, S., Cantori, I., Castaman, G., Castiglia, P., Coluccia, A., Coppetelli, U., Coppola, A., Cultrera, D., De Candia, E., Delios, G., Di Gennaro, L., Di Gregorio, P., Di Minno, M., Dragani, A., Pietro Ettorre, C., Franchini, M., Galli, M., Gallo, G., Giordano, P., Giuffrida, G., Iannaccaro, P., Lassandro, G., Lazzareschi, I., Linari, S., Luciani, M., Macchi, S., Malcangi, G., Malizia, R., Marietta, M., Marino, R., Massoud, M., Gabriella Mazzucconi, M., Milan, M., Morfini, M., Napolitano, M., Pasca, S., Pedrazzi, P., Peyvandi, F. A., Piscitelli, L., Pollio, B., Preti, P., Quintavalle, G., Radossi, P., Raso, S., Ricca, I., Rocino, A., Santoro, C., Carlotta Santoro, R., Sarolo, L., Schiavoni, M., Schiavulli, M., Sciancalepore, P., Luisa Serino, M., Mario Siragusa, S., Sottilotta, G., Svahn, J., Valdre, L., Cristina Vedovati, M., and Zanon, E.

Subjects
Adult, medicine.medical_specialty, Consensus, Delphi Technique, Vaccination schedule, Delphi method, haemophilia, 030204 cardiovascular system & hematology, Hemophilia A, Haemophilia, immunization, Hemophilia B, bleeding disorder, factor VIII inhibitor, vaccination, Child, Evidence-Based Medicine, Humans, Italy, Vaccination, 03 medical and health sciences, 0302 clinical medicine, Vaccine administration, Medicine, In patient, Clinical Haemophilia, Genetics (clinical), business.industry, Original Articles, Hematology, General Medicine, Evidence-based medicine, medicine.disease, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Immunization, Family medicine, Original Article, business, 030215 immunology
Abstract

Vaccination against communicable diseases is crucial for disease prevention, but this practice poses challenges to healthcare professionals in patients with haemophilia. Poor knowledge of the vaccination requirements for these patients and safety concerns often result in vaccination delay or avoidance. In order to address this issue, a panel of 11 Italian haemophilia and immunization experts conducted a Delphi consensus process to identify the main concerns regarding the safe use of vaccines in patients with haemophilia. The consensus was based on a literature search of the available evidence, which was used by the experts to design 27 consensus statements. A group of clinicians then rated these statements using the 5‐point Likert‐type scale (1 = strongly disagree; 5 = strongly agree). The main issues identified by the expert panel included vaccination schedule for haemophilic patients; protocol and optimal route of vaccine administration; vaccination of haemophilic patients with antibodies inhibiting coagulation factor VIII (inhibitors); and vaccination and risk of inhibitor development. This manuscript discusses these controversial areas in detail supported by the available literature evidence and provides evidence‐ and consensus‐based recommendations. Overall, participants agreed on most statements, except those addressing the potential role of vaccination in inhibitor formation. Participants agreed that patients with haemophilia should receive vaccinations according to the institutional schedule for individuals without bleeding disorders; however, vaccination of patients with haemophilia requires comprehensive planning, taking into account disease severity, type and route of vaccination, and bleeding risk. Data also suggest vaccination timing does not need to take into consideration when the patient received factor VIII replacement.

Published
2019

39. Laparoscopically Assisted Transperineal Approach in the Management of a Giant Pelvic Lipoma

Author

Baccarani, A., Bonetti, E., Pedone, A., De Santis, G., Pappalardo, M., Romano, A., Sighinolfi, C., and Rocco, B.

Subjects
body regions, Ideas and Innovations, Reconstructive
Abstract

Summary: Giant lipomas affecting the retroperitoneum and pelvis are quite rare. The surgical management of these lesions may be technically demanding and controversies exist with respect to diagnosis, competences being involved, type of surgical approach, radicality, and timing. A unique case presentation of a giant lipoma occupying the whole pelvis and the gluteal region is presented. Due to its size, many anatomical areas are involved, requiring the expertise of multiple specialists to treat. After multidisciplinary counseling, the lesion is radically resected in one stage by using a new videolaparoscopically assisted transperineal access to the pelvis. This type of surgical approach may be of interest for resecting pelvic tumors in women and men.

Published
2020

49. Introduction

Author

Bernardini, G., Prati, M., Bonetti, E., Scarì, G., Bernardini, G., Prati, M., Bonetti, E., and Scarì, G.

Published
1999
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