485 results on '"Bonfanti, R"'
Search Results
2. Effectiveness of switching from first-generation basal insulin to Glargine 300 U/mL in children and adolescents with type 1 diabetes: results from the ISPED CARD database.
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Rossi, Maria Chiara, Bonfanti, Riccardo, Graziano, Giusi, Larosa, Monica, Lombardo, Fortunato, Nicolucci, Antonio, Vespasiani, Giacomo, Zucchini, Stefano, Rabbone, Ivana, Bracciolini, G. P., Cherubini, V., Bobbio, A., Zucchini, S., Suprani, T., De Donno, V., Lombardo, F., Bonfanti, R., Franzese, A., Rabbone, I., and Graziani, V.
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TYPE 1 diabetes ,DIABETES in children ,GLYCOSYLATED hemoglobin ,INSULIN therapy ,ELECTRONIC health records - Abstract
Aims: Glargine 300 U/mL (Gla-300) has been recently approved for use in children and adolescents with type 1 diabetes (T1D). However, real-world effectiveness data are scarce, and aim of this analysis was to assess clinical outcomes in young patients with T1D switching from 1st generation basal insulin (1BI) to Gla-300. Methods: ISPED CARD is a retrospective, multicenter study, based on data anonymously extracted from Electronic Medical Records. The study involved a network of 20 pediatric diabetes centers. Data on all patients aged < 18 years with T1D switching from 1BI to Gla-300 were analyzed to assess clinical characteristics at the switch and changes after 6 and 12 months in glycated hemoglobin (HbA1c), fasting blood glucose (FBG), and standardized body mass index (BMI/SDS). Titration of basal and short-acting insulin doses was also evaluated. Results: Overall, 200 patients were identified. The mean age at the switch to Gla-300 was 13 years, and mean duration of diabetes was 3.9 years. Average HbA1c levels at switch were 8.8%. After 6 months, HbA1c levels decreased by − 0.88% (95% CI − 1.28; − 0.48; p < 0.0001). The benefit was maintained after 12 months from the switch (mean reduction of HbA1c levels − 0.80%, 95% CI − 1.25; − 0.35, p = 0.0006). Trends of reduction in FBG levels were also evidenced both at 6 months and 12 months. No significant changes in short-acting and basal insulin doses were documented. Conclusions: The study provides the first real-world evidence of the effectiveness of Gla-300 in children and adolescents with T1D previously treated with 1BI. The benefits in terms of HbA1c levels reduction were substantial, and sustained after 12 months. Additional benefits can be expected by improving the titration of insulin doses. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Case report: A case of Rabson-Mendenhall syndrome: long-term follow-up and therapeutic management with empagliflozin.
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Foglino, R., Barbetti, F., Morotti, E., Castorani, V., Rigamonti, A., Frontino, G., Barera, G., and Bonfanti, R.
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SODIUM-glucose cotransporters ,SODIUM-glucose cotransporter 2 inhibitors ,METABOLIC syndrome ,EMPAGLIFLOZIN ,GLYCEMIC control ,INSULIN receptors ,THERAPEUTICS - Abstract
Background: Rabson-Mendenhall syndrome (RMS), a rare disorder characterized by severe insulin resistance due to biallelic loss-of-function variants of the insulin receptor gene (INSR), presents therapeutic challenges (OMIM: 262190). This case study explores the efficacy of adjunctive therapy with sodium-glucose cotransporter 2 inhibitors (SGLT2is) in the management of RMS in an 11-year-old male patient with compound heterozygous pathogenic variants of INSR. Methods: Despite initial efforts to regulate glycemia with insulin therapy followed by metformin treatment, achieving stable glycemic control presented a critical challenge, characterized by persistent hyperinsulinism and variable fluctuations in glucose levels. Upon the addition of empagliflozin to metformin, notable improvements in glycated hemoglobin (HbA1c) and time in range (TIR) were observed over a 10-month period. Results: After 10 months of treatment, empagliflozin therapy led to a clinically meaningful reduction in HbA1c levels, decreasing from 8.5% to 7.1%, along with an improvement in TIR from 47% to 74%. Furthermore, regular monitoring effectively averted normoglycemic ketoacidosis, a rare complication associated with SGLT2 inhibitor therapy. Conclusion: This case highlights the potential of SGLT2i as adjunctive therapy in RMS management, particularly in stabilizing glycemic variability. However, further research is warranted to elucidate the long-term efficacy and safety of this therapeutic approach in RMS and similar insulin resistance syndromes. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Continuous improvement of quality of care in pediatric diabetes: the ISPED CARD clinical registry.
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Nicolucci, Antonio, Graziano, Giusi, Lombardo, Fortunato, Rabbone, Ivana, Rossi, Maria Chiara, Vespasiani, Giacomo, Zucchini, Stefano, Bonfanti, Riccardo, Bracciolini, G. P., Cherubini, V., Bobbio, A., Zucchini, S., Suprani, T., Donno, V., Lombardo, F., Bonfanti, R., Franzese, A., Rabbone, I., Graziani, V., and Zampolli, M.
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DIABETES in children ,PEDIATRIC therapy ,TYPE 1 diabetes ,ELECTRONIC health records ,INSULIN ,LDL cholesterol - Abstract
Aim: In Italy, the ISPED CARD initiative was launched to measure and improve quality of care in children and adolescents with type 1 diabetes. Methods: Process and outcome indicators and the related information derived from electronic medical records were identified. A network of pediatric diabetes centers was created on a voluntary basis. Results: Overall, 20 centers provided data on 3284 patients aged < = 18 years. HbA1c was monitored ≥ 2/year in 81.2% of the cases. BMI was monitored ≥ 1/year in 99.0%, lipid profile in 45.3%, and blood pressure in 91.7%. Pubertal status, albuminuria, eye examination, and screening of celiac disease and thyroiditis were underreported. From 2017 to 2021, average HbA1c levels decreased from 7.8 ± 1.2 to 7.6 ± 1.3%, while patients with LDL cholesterol > 100 mg/dl increased from 18.9 to 36.7%. Prevalence of patients with elevated blood pressure and BMI/SDS values also increased. In 2021, 44.7% of patients were treated with the newest basal insulins, while use of regular human insulin had dropped to 7.7%. Use of insulin pump remained stable (37.9%). Conclusions: This report documents the feasibility of the ISPED CARD initiative and shows lights and shadows in the care provided. Improving care, increasing number of centers, and ameliorating data recording represent future challenges. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Corrigendum: The silent epidemic of diabetic ketoacidosis at diagnosis of type 1 diabetes in children and adolescents in italy during the covid-19 pandemic in 2020(Front. Endocrinol., (2022), 13, (878634), 10.3389/fendo.2022.878634)
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Cherubini, V., Marino, M., Scaramuzza, A. E., Tiberi, V., Bobbio, A., Delvecchio, M., Piccinno, E., Ortolani, F., Innaurato, S., Felappi, B., Gallo, F., Ripoli, C., Ricciardi, M. R., Pascarella, F., Stamati, F. A., Citriniti, F., Arnaldi, C., Monti, S., Graziani, V., De Berardinis, F., Giannini, C., Chiarelli, F., Zampolli, M., De Marco, R., Bracciolini, G. P., Grosso, C., De Donno, V., Piccini, B., Toni, S., Coccioli, S., Cardinale, G., Bassi, M., Minuto, N., D?annunzio, G., Maffeis, C., Marigliano, M., Zanfardino, A., Iafusco, D., Rollato, A. S., Piscopo, A., Curto, S., Lombardo, F., Bombaci, B., Sordelli, S., Mameli, C., Macedoni, M., Rigamonti, A., Bonfanti, R., Frontino, G., Predieri, B., Bruzzi, P., Mozzillo, E., Rosanio, F., Franzese, A., Piredda, G., Cardella, F., Iovane, B., Calcaterra, V., Berioli, M. G., Lasagni, A., Pampanini, V., Patera, P. I., Schiaffini, R., Rutigliano, I., Meloni, G., De Sanctis, L., Tinti, D., Trada, M., Guerraggio, L. P., Franceschi, R., Cauvin, V., Tornese, G., Franco, F., Musolino, G., Maltoni, G., Talarico, V., Iannilli, A., Lenzi, L., Matteoli, M. C., Pozzi, E., Moretti, C., Zucchini, S., Rabbone, I., Gesuita, R., Cherubini, V., Marino, M., Scaramuzza, A. E., Tiberi, V., Bobbio, A., Delvecchio, M., Piccinno, E., Ortolani, F., Innaurato, S., Felappi, B., Gallo, F., Ripoli, C., Ricciardi, M. R., Pascarella, F., Stamati, F. A., Citriniti, F., Arnaldi, C., Monti, S., Graziani, V., De Berardinis, F., Giannini, C., Chiarelli, F., Zampolli, M., De Marco, R., Bracciolini, G. P., Grosso, C., De Donno, V., Piccini, B., Toni, S., Coccioli, S., Cardinale, G., Bassi, M., Minuto, N., D'Annunzio, G., Maffeis, C., Marigliano, M., Zanfardino, A., Iafusco, D., Rollato, A. S., Piscopo, A., Curto, S., Lombardo, F., Bombaci, B., Sordelli, S., Mameli, C., Macedoni, M., Rigamonti, A., Bonfanti, R., Frontino, G., Predieri, B., Bruzzi, P., Mozzillo, E., Rosanio, F., Franzese, A., Piredda, G., Cardella, F., Iovane, B., Calcaterra, V., Berioli, M. G., Lasagni, A., Pampanini, V., Patera, P. I., Schiaffini, R., Rutigliano, I., Meloni, G., De Sanctis, L., Tinti, D., Trada, M., Guerraggio, L. P., Franceschi, R., Cauvin, V., Tornese, G., Franco, F., Musolino, G., Maltoni, G., Talarico, V., Iannilli, A., Lenzi, L., Matteoli, M. C., Pozzi, E., Moretti, C., Zucchini, S., Rabbone, I., and Gesuita, R.
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socioeconomic status ,COVID - 19 ,type 1 diabetes ,DKA ,socioeconomic statu ,diabetes onset - Abstract
In the published article, there was an error in affiliation(s) 29. Instead of “Departement of Pediatrics, Diabetes Research Institute, IRCCS San Raffaele, Milano, Italy”, it should be “Diabetes Research Institute, IRCCS San Raffaele Hospital, Milan, Italy”. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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- 2022
6. exocrine pancreas function is impaired in adult relatives of patient with type 1 diabetes
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Giovenzana A, Vecchio F, Cugnata F, Nonis A, Mandelli A, Stabilini A, Mazzi BA, De Pellegrin M, Laurenzi A, Bonfanti R, Battaglia M, Bosi E, Petrelli A., Giovenzana, A, Vecchio, F, Cugnata, F, Nonis, A, Mandelli, A, Stabilini, A, Mazzi, Ba, De Pellegrin, M, Laurenzi, A, Bonfanti, R, Battaglia, M, Bosi, E, and Petrelli, A.
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- 2022
7. Hemoglobin A1c trajectories in the first 18 months after diabetes diagnosis in the SWEET diabetes registry
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Prahalad P, Schwandt A, Besancon S, Mohan M, Obermannova B, Kershaw M, Bonfanti R, Pundziute Lycka A, Hanas R, Casteels K, and SWEET Study Group the
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General Economics, Econometrics and Finance - Published
- 2022
8. The critical role of didodecyldimethylammonium bromide on physico-chemical, technological and biological properties of NLC
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Carbone, C., Campisi, A., Manno, D., Serra, A., Spatuzza, M., Musumeci, T., Bonfanti, R., and Puglisi, G.
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- 2014
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9. Survey on the use of insulin pumps in Italy: comparison between pediatric and adult age groups (IMITA study)
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Bonfanti, R., Lepore, G., Bozzetto, L., Corsi, A., Di Blasi, V., Girelli, A., Grassi, G., Iafusco, D., Rabbone, I., Schiaffini, R., Laviola, L., Bruttomesso, D., and the Italian Study Group on Diffusion of CSII in Italy
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- 2016
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10. Current status of Drosophila suzukii classical biological control in Italy
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Lisi, F., Biondi, A., Cavallaro, C., Zappalà, L., Campo, G., Roversi, P. F., Sabbatini Peverieri, G., Giovannini, L., Tavella, L., Tortorici, F., Bardella, S., Carli, C., Bosio, G., Mori, N., Tonina, L., Zanini, G., Caruso, S., Vaccari, G., Masetti, A., Bittau, B., Bariselli, M., Schmidt, S., Falagiarda, M., Bertignono, L., Bonfanti, R., Giorgini, M., Guerrieri, E., Tropiano, F. G., Verrastro, V., Baser, N., Ibn Amor, A., Endrizzi, S., Tessari, L., Puppato, S., Ioriatti, C., Grassi, A., Anfora, G., Fellin, L., Rossi, Stacconi, and M. V.
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Settore AGR/11 - ENTOMOLOGIA GENERALE E APPLICATA ,importation biological control ,Parasidoid ,host range ,IPM ,Horticulture ,Ganaspis brasiliensis ,Ganaspis brasiliensis, host range, invasive species, importation biological control, IPM, parasitoid ,parasitoid ,invasive species - Published
- 2022
11. Health-related quality of life and treatment preferences in adolescents with type 1 diabetes. The VIPKIDS study
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Cherubini, V., Gesuita, R., Bonfanti, R., Franzese, A., Frongia, A. P., Iafusco, D., Iannilli, A., Lombardo, F., Rabbone, I., Sabbion, A., Salvatoni, A., Scaramuzza, A., Schiaffini, R., Sulli, N., Toni, S., Tumini, S., Mosca, A., Carle, F., and VIPKIDS Study Group
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- 2014
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12. The laparoscopic mini-gastric bypass: the Italian experience: outcomes from 974 consecutive cases in a multicenter review
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Musella, M., Susa, A., Greco, F., De Luca, M., Manno, E., Di Stefano, C., Milone, M., Bonfanti, R., Segato, G., Antonino, A., and Piazza, L.
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- 2014
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13. Management of hyperosmolar hyperglycaemic state in adults with diabetes
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Frontino, G., Bonfanti, R., Rigamonti, A., Battaglino, R., Favalli, V., Bonura, C., Meschi, F., and Barera, G.
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- 2016
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14. Diabetic ketoacidosis at the onset of disease during a national awareness campaign: A 2-year observational study in children aged 0-18 years
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Rabbone I., Maltoni G., Tinti D., Zucchini S., Cherubini V., Bonfanti R., Scaramuzza A., Lera R., Bobbio A., Piccinno E., Reinstadler P., Felappi B., Prandi E., Gallo F., Frongia AP., Ripoli C., Lo Presti D., Tomaselli L., Cardinale G., Stamati FA., Citriniti F., Suprani T., Graziani V., De Berardinis F., Zampolli M., De Marco R., Cavalli C., Lazzaro N., De Donno V., Toni S., Piccini B., Lenzi L., Mainetti B., Coccioli MS., d'Annunzio G., Minuto N., Aloe S., Lucchesi D., Cirillo S., Sordelli M., Del Vecchio F., Salzano LG., Meschi F., Iughetti L., Predieri B., Franzese A., Mozzillo Enza., Iafusco D., Cadario F., Savastio S., Piredda G., Cardella F., Iovane B., Calcaterra V., Berioli MG., Biagioni M., Randazzo E., Patera I., Schiaffini R., Rutigliano I., Lasagni A., Innaurato S., Gaiero A., Fichera G., Trada M., Guerraggio L., Cauvin V., Franceschi R., Tornese G., Salvatoni A., Marigliano M., Sabbion A., Maffeis C., Arnaldi C., Rabbone, I., Maltoni, G., Tinti, D., Zucchini, S., Cherubini, V., Bonfanti, R., Scaramuzza, A., Lera, R., Bobbio, A., Piccinno, E., Reinstadler, P., Felappi, B., Prandi, E., Gallo, F., Frongia, Ap., Ripoli, C., Lo Presti, D., Tomaselli, L., Cardinale, G., Stamati, Fa., Citriniti, F., Suprani, T., Graziani, V., De Berardinis, F., Zampolli, M., De Marco, R., Cavalli, C., Lazzaro, N., De Donno, V., Toni, S., Piccini, B., Lenzi, L., Mainetti, B., Coccioli, Ms., D'Annunzio, G., Minuto, N., Aloe, S., Lucchesi, D., Cirillo, S., Sordelli, M., Del Vecchio, F., Salzano, Lg., Meschi, F., Iughetti, L., Predieri, B., Franzese, A., Mozzillo, Enza., Iafusco, D., Cadario, F., Savastio, S., Piredda, G., Cardella, F., Iovane, B., Calcaterra, V., Berioli, Mg., Biagioni, M., Randazzo, E., Patera, I., Schiaffini, R., Rutigliano, I., Lasagni, A., Innaurato, S., Gaiero, A., Fichera, G., Trada, M., Guerraggio, L., Cauvin, V., Franceschi, R., Tornese, G., Salvatoni, A., Marigliano, M., Sabbion, A., Maffeis, C., Arnaldi, C., Rabbone, Ivana, Maltoni, Giulio, Tinti, Davide, Zucchini, Stefano, Cherubini, Valentino, Bonfanti, Riccardo, Scaramuzza, Andrea, Lera, Riccardo, Bobbio, Adriana, Piccinno, Elvira, Reinstadler, Petra, Felappi, Barbara, Prandi, Elena, Gallo, Francesco, Frongia, Anna Paola, Ripoli, Carlo, Lo Presti, Donatella, Tomaselli, Letizia, Cardinale, Giuliana, Stamati, Filomena Andreina, Citriniti, Felice, Suprani, Tosca, Graziani, Vanna, De Berardinis, Fiorella, Zampolli, Maria, De Marco, Rosaria, Cavalli, Claudio, Lazzaro, Nicola, De Donno, Valeria, Toni, Sonia, Piccini, Barbara, Lenzi, Lorenzo, Mainetti, Benedetta, Coccioli, Maria Susanna, D’Annunzio, Giuseppe, Minuto, Nicola, Aloe, Monica, Lucchesi, Sonia, Cirillo, Dante, Sordelli, Silvia, Delvecchio, Maurizio, Lombardo, Fortunato, Salzano, Giusy, Meschi, Franco, Iughetti, Lorenzo, Predieri, Barbara, Franzese, Adriana, Mozzillo, Enza, Iafusco, Dario, Cadario, Francesco, Savastio, Silvia, Cardella, Francesca, Iovane, Brunella, Calcaterra, Valeria, Berioli, Maria Giulia, Biagioni, Martina, Randazzo, Emioli, Patera, Ippolita Patrizia, Schiaffini, Riccardo, Rutigliano, Irene, Lasagni, Anna, Innaurato, Silvia, Gaiero, Alberto, Fichera, Grazziella, Trada, Michela, Guerraggio, Lucia, Cauvin, Vittoria, Franceschi, Roberto, Tornese, Gianluca, Salvatoni, Alessandro, Marigliano, Marco, Sabbion, Alberto, Maffeis, Claudio, and Arnaldi, Claudia
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Blood Glucose ,Male ,medicine.medical_specialty ,Pediatrics ,endocrine system diseases ,Diabetic ketoacidosis ,Adolescent ,030209 endocrinology & metabolism ,Disease ,03 medical and health sciences ,0302 clinical medicine ,diabetic ketoacidosis ,Patient Education as Topic ,Diabetes mellitus ,Epidemiology ,Medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Child ,Type 1 diabetes ,diabetes ,business.industry ,Incidence (epidemiology) ,Incidence ,epidemiology ,Infant, Newborn ,diabetic ketoacidosi ,nutritional and metabolic diseases ,Infant ,medicine.disease ,Diabetes Mellitus, Type 1 ,Italy ,diabete ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Observational study ,Female ,business ,Prevention campaign - Abstract
ObjectiveAfter a previous survey on the incidence of diabetic ketoacidosis (DKA) at onset of type 1 diabetes in children in 2013–2014 in Italy, we aimed to verify a possible decline in the incidence of DKA at onset during a national prevention campaign.DesignProspective observational study.SettingMulticentre study throughout Italy.InterventionNational awareness campaign started in November 2015 and held until December 2017.PatientsDuring 2016 and 2017 we collected data on all patients aged 0–18 years with new-onset diabetes.Main outcome measuresDKA (pH ResultsRecords (n=2361) of children with newly diagnosed type 1 diabetes were collected from 58 out of 68 (85.3%) centres of the original survey participants and 100% of the previously surveyed tertiary centres. Overall, DKA was observed in 1124 patients, with an increased rate when compared with the previous survey (47.6% vs 38.5%, p=0.002), and severe DKA in 15.3%. In children below 6 years, DKA was observed in 323 out of 617 (52.5%) and severe DKA in 16.7%; in this age group, occurrence of DKA reduced by 21.3% (p=0.009). DKA treatment according to the ISPED guidelines was adopted in 95% of the centres, with a 27% improvement (p=0.025).ConclusionsDuring a 2-year awareness campaign, DKA at onset of diabetes in children and adolescents 0–18 years is still common and increased when compared with the 2013–2014 survey.
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- 2020
15. PREDICTIVE LOW-GLUCOSE SUSPEND (TANDEM T:SLIM X2 BASAL IQ) IS EFFECTIVE IN YOUNG CHILDREN WITH TYPE 1 DIABETES
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Scaramuzza, A, Rabbone, I, Bonfanti, R, Cherubini, V, Iafusco, D, Minuto, N, Toni, S, Maltoni, G, Mozzillo, E, Rapini, N, Marigliano, M, Piccinno, E, Ripoli, C, Lo Presti, D, Tinti, D, Rigamonti, A, Casertano, A, Delvecchio, M (Delvecchio, M. ), Scaramuzza, A, Rabbone, I, Bonfanti, R, Cherubini, V, Iafusco, D, Minuto, N, Toni, S, Maltoni, G, Mozzillo, E, Rapini, N, Marigliano, M, Piccinno, E, Ripoli, C, Lo Presti, D, Tinti, D, Rigamonti, A, Casertano, A, Delvecchio, M, (Delvecchio, and M., ).
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- 2020
16. Social comparison on facebook and its effect on an individual's well-being
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Bonfanti R. C., Lo Coco G., Ruggieri S., Kahn, Walter, Bonfanti R.C., Lo Coco G., and Ruggieri S.
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Social network sites ,Facebook ,Wellbeing ,Social comparison - Abstract
Social comparison is the process through which people compare their opinions, abilities, behaviours and emotions with those of others for selfevaluation and to obtain an external guide for themselves. There is wide evidence that social comparison is a pervasive behaviour, particularly among adults, both in their social life and in online relationships established through Social Network Sites. A growing number of studies show unmistakably that online social comparison through social media can influence people's everyday life. Features such as Facebook's News Feed or Instagram's Daily Stories provide a stream of information about friends' lives, achievements, abilities and personality, creating a perfect environment for social comparison to take place. Researchers have therefore begun to examine more closely how social comparison operates on Social Network Sites, given that social media allows users to constantly monitor what friends are doing and talking about, and how others are responding. In this chapter, online social comparison is analysed from a social psychological perspective by examining the classical theories and the most recent theoretical contributions of the construct, and above all by highlighting the main differences in interpretations about its occurrence in face-to-face and social media contexts. Recent perspectives on clinical outcomes and mental health are also discussed.
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- 2021
17. Minimal incidence of neonatal/infancy onset diabetes in Italy is 1:90,000 live births
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Iafusco, D., Massa, O., Pasquino, B., Colombo, C., Iughetti, L., Bizzarri, C., Mammì, C., Lo Presti, D., Suprani, T., Schiaffini, R., Nichols, Colin G., Russo, L., Grasso, V., Meschi, F., Bonfanti, R., Brescianini, S., Barbetti, F., and The Early Diabetes Study Group of ISPED
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- 2012
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18. Permanent diabetes during the first year of life: multiple gene screening in 54 patients
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Russo, L., Iafusco, D., Brescianini, S., Nocerino, V., Bizzarri, C., Toni, S., Cerutti, F., Monciotti, C., Pesavento, R., Iughetti, L., Bernardini, L., Bonfanti, R., Gargantini, L., Vanelli, M., Aguilar-Bryan, L., Stazi, M. A., Grasso, V., Colombo, C., Barbetti, F., and the ISPED Early Diabetes Study Group
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- 2011
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19. Pros and cons of Minimed 670G hybrid closed-loop system: first 6-month experience in Italy
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Scaramuzza A, Minuto N, Marigliano M, Tornese G, Gallo F, De Donno V, Iovane B, De Berardinis F, Zanfardino A, Franceschi R, Delvecchio M, Iafusco D, Maffeis C, Bonfanti R., Scaramuzza, A, Minuto, N, Marigliano, M, Tornese, G, Gallo, F, De Donno, V, Iovane, B, De Berardinis, F, Zanfardino, A, Franceschi, R, Delvecchio, M, Iafusco, D, Maffeis, C, and Bonfanti, R.
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CSII ,diabetes - Published
- 2019
20. Synergic pro-apoptotic effects of Ferulic Acid and nanostructured lipid carrier in GBM cells assessed through molecular and DL studies
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Grasso R, Dell'Albani P, Carbone C, Spatuzza M, Bonfanti R, Sposito G, Puglisi G, Musumeci F, Scordino A, and Campisi A
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Ferulic acid ,Nanostructured lipid carrier ,Glioblastoma ,Delayed Luminescence - Abstract
Herein, we assessed the effect of Ferulic Acid (FA), a natural antioxidant with anti-cancer effect, on the human glioblastoma cells through molecular and Delayed Luminescence (DL) studies. DL, a phenomenon of ultra-week emission of optical photons, was used to monitor mitochondrial assessment. The effect of FA loaded in nanostructured lipid carriers (NLCs) was also assessed. To validate NLCs as a drug delivery system for glioblastoma treatment, particular attention was focused on their effect. We found that free FA induced a significant decrease in c-Myc and Bcl-2 expression levels accompanied by the apoptotic pathway activation. Blank NLCs, even if they did not induce cytotoxicity and caspase-3 cleavage, decreased Bcl-2, ERK1/2, c-Myc expression levels activating PARP-1 cleavage. The changes in DL intensity and kinetics highlighted a possible effect of nanoparticle matrix on mitochondria, through the involvement of the NADH pool and ROS production that, in turn, activates ERK1/2 pathways. All the effects on protein expression levels and on the activation of apoptotic pathway appeared more evident when the cells were exposed to FA loaded in NLCs. We demonstrated that the observed effects are due to a synergic pro-apoptotic influence exerted by FA, whose bio-availability increases in the glioblastoma cells, and NLCs formulation.
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- 2020
21. Sulfonylurea treatment outweighs insulin therapy in short-term metabolic control of patients with permanent neonatal diabetes mellitus due to activating mutations of the KCNJ11 (KIR6.2) gene
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Tonini, G., Bizzarri, C., Bonfanti, R., Vanelli, M., Cerutti, F., Faleschini, E., Meschi, F., Prisco, F., Ciacco, E., Cappa, M., Torelli, C., Cauvin, V., Tumini, S., Iafusco, D., Barbetti, F., and Early-Onset Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetology
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- 2006
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22. Continuous Subcutaneous Insulin Infusion in Italy: Third National Survey
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Bruttomesso D., Laviola L., Lepore G., Bonfanti R., Bozzetto L., Corsi A., Di Blasi V., Girelli A., Grassi G., Iafusco D., Rabbone I., Schiaffini R., Montani V., Colleluori P., Paciotti V., Alfidi P., Grosso J., Tumini S., Cipriano P., Vitacolonna E., Di Vieste G., Minnucci A., Antenucci D., La Penna G., Taraborrelli M., Macerala B., Citro G., De Morelli G., Gnasso A., Irace C., Citriniti F., Lazzaro N., Bruzzese M., Mammi F., De Berardinis F., Santoro E., Corigliano G., Corigliano M., Parillo M., Schettino M., Fresa R., Annuzzi G., Bassi V., Santinelli C., Buono P., Mozzillo E., De Feo E., Esposito K., Petrizzo M., Foglia A., Gatti A., Gentile S., Guarino G., Zanfardino A., Lambiase C., Vitale A., Zucchini S., Maltoni G., Forlani G., Moscatiello S., Suprani T., Bensa M., Tomasi F., Monesi M., Nizzoli M., Acquati S., Chierici G., Milli B., Iughetti L., Predieri B., Cavani R., Romano S., Manicardi V., Michelini M., Cimicchi M. C., Ugolotti D., Zavaroni I., Dei Cas A., Dall'Aglio E., Papi M., Tardio S. M., Calderini M. C., Riboni S., D'Amato L., Zavaroni D., Gastaldi L., Di Bartolo P., Pellicano F., Cirillo A., Graziani V., Di Secli C., Amarri S., Lasagni A., Marsciani A., Pedini A., Pagliani U., Rossi C., Tortul C., Brunato B., Assaloni R., Zanette G., Livolsi P., Petrucco A., Tercelj K., Manca E., Candido R., Tommasi E., Tornese G., Faleschini E., Tonutti L., Agus S., Zanatta M., Rosolen A., Comici A., Graziano F. M., Misischi I., Pozzilli P., Maurizi A. R., Falasca P., Tuccinardi F., Ricciardi G. P., Di Masa P., Ragonese M., Cipolloni L., Buzzetti R., Moretti C., Leto G., Crino A., Bocchini S., Di Perna P., Giuliano M., Frontoni S., Malandrucco I., Pitocco D., Scalpone R., Toscanella F., Cappa M., Ventura C., Bonato V., De Bernardinis M., Cavallo M. G., Leonetti F., Morano S., Mandosi E., Cicconetti E., Ciampittiello G., Marini M. A., Sabato D., Napoli A., Giraudo F., Toscano V., Massimiani F., Fava D., Gargiulo P., Mecca N., Tubili C., Nardone M. R., Morviducci L., Manca-Bitti M. L., Arcano S., Leotta S., Suraci C., Chiaramonte F., Visalli N., Forte E., Palmacci C., Arnaldi C., Tosini D., Querci F., Trevisan R., Bonfadini S., Prandi E., Felappi B., Locatelli F., Fuso V., Rocca A., Meneghini E., Massafra C., Terni T., Elli P., Ruggeri P., Carrai E., Musacchio N., Lovagnini Scher C. A., Marelli G., Vilei V., Richini D., Inversini C., Franzetti I., Bonacina M., Ciucci A., Sciangula L., Duratorre E., Bonomo M., Bertuzzi F., Chebat E., Muratori M., Scaramuzza A., Zuccotti G. V., Bollati P. M., Colapinto P., Orsi E., Palmieri E., Laurenzi A., Molinari C., Frontino G., Veronelli A., Zecchini B., Bianchi A., Torchio G., Lovati E., Ghilardi G., Dagani R., Carugo D., Berra C., Favacchio G., Fochesato E., Pissarelli A., Bucciarelli L., Bulgheroni M., Guerraggio L., Zonca S., Bossi A. C., Berzi D., Mangone I., Cazzaniga E., Rabini R. A., Boemi M., Faloia E., Boscaro M., Sternari G., Iannilli A., Cherubini V., Busciantella Ricci N., Cartechini M. G., Tesei A. M., Maolo G., Galetta M., Vespasiani G., Tinti G., Manfrini S., Aiello A., Di Vincenzo S., Vitale C., Di Caro P., Lera R., Secco A., Lesina A., Romeo F., Origlia C., Giorda C., Chiambretti A. M., Fornengo R., De Donno V., Gallarotti F., Manti R., Marafetti L., Cadario F., Savastio S., Barbieri P., Massucco P., Ali A., Gottero C., Degiovanni M., Bertaina S., Maghenzani G., Tinti D., Fontana F., Giorgino F., Stefanelli G., Cavallo L., Zecchino C., Piccinno E., Ortolani F., Gallo F., Moramarco F., Marino A., Sparasci G., Mileti G., Lamacchia O., Picca G., Coccioli M. S., Micale F., Serra R., Romano I., Savino T., De Cosmo S., Rauseo A., Delvecchio M., Lapolla R., Braione A. F., Papagno G., Baroni M., Melis M., Cossu E., Songini M., Cambuli V. M., Lo Presti D., Timpanaro T. A., Chiavetta A., Garofalo M. R., Tommaselli L., Tumminia A., Scarpitta A. M., Di Benedetto A., Giunta L., Lombardo F., Salzano G., Cardella F., Roppolo R., Provenzano V., Fleres M., Migliorini S., De Luca A., Leopardi A., Beltrami C., Toni S., Guasti G., Lenzi L., Lamanna C., Mannucci E., Lucchesi S., Dicianni G., Aragona M., Del Prato S., Fattor B., Eisath J., Pasquino B., Reinstadler P., Kaufmann P., Incelli G., Rauch S., Romanelli T., Cauvin V., Franceschi R., Soldani C., Scattoni R., Norgiolini R., Celleno R., Torlone E., Bolli G. B., Lalli C., Scarponi M., Bobbio A., Bechaz M., Pianta A., Marangoni A., Arico C. N., Alagona C., Confortin L., Rossi E., Boscolo Bariga A., Nogara A., Bettio M., Frison V., Guidoni G. L., Fongher C., Contin M. L., Cosma A., Vianello S., Bondesan L., Morea A., Volpi A., Coracina A., Panebianco G., Lombardi S., Costa S., Cipponeri E., Vedovato M., Scotton R., Monciotti C. M., Galderisi A., Dalfra M. G., Lapolla A., Zanon M., Lisato G., Mollo F., Calcaterra F., Miola M., Paccagnella A., Sambataro M., Moro E., Trombetta M., Negri C., Sabbion A., Maffeis C., Strazzabosco M., Mesturino C. A., Mingardi R., Bruttomesso, D., Laviola, L., Lepore, G., Bonfanti, R., Bozzetto, L., Corsi, A., Di Blasi, V., Girelli, A., Grassi, G., Iafusco, D., Rabbone, I., Schiaffini, R., Montani, V., Colleluori, P., Paciotti, V., Alfidi, P., Grosso, J., Tumini, S., Cipriano, P., Vitacolonna, E., Di Vieste, G., Minnucci, A., Antenucci, D., La Penna, G., Taraborrelli, M., Macerala, B., Citro, G., De Morelli, G., Gnasso, A., Irace, C., Citriniti, F., Lazzaro, N., Bruzzese, M., Mammi, F., De Berardinis, F., Santoro, E., Corigliano, G., Corigliano, M., Parillo, M., Schettino, M., Fresa, R., Annuzzi, G., Bassi, V., Santinelli, C., Buono, P., Mozzillo, E., De Feo, E., Esposito, K., Petrizzo, M., Foglia, A., Gatti, A., Gentile, S., Guarino, G., Zanfardino, A., Lambiase, C., Vitale, A., Zucchini, S., Maltoni, G., Forlani, G., Moscatiello, S., Suprani, T., Bensa, M., Tomasi, F., Monesi, M., Nizzoli, M., Acquati, S., Chierici, G., Milli, B., Iughetti, L., Predieri, B., Cavani, R., Romano, S., Manicardi, V., Michelini, M., Cimicchi, M. C., Ugolotti, D., Zavaroni, I., Dei Cas, A., Dall'Aglio, E., Papi, M., Tardio, S. M., Calderini, M. C., Riboni, S., D'Amato, L., Zavaroni, D., Gastaldi, L., Di Bartolo, P., Pellicano, F., Cirillo, A., Graziani, V., Di Secli, C., Amarri, S., Lasagni, A., Marsciani, A., Pedini, A., Pagliani, U., Rossi, C., Tortul, C., Brunato, B., Assaloni, R., Zanette, G., Livolsi, P., Petrucco, A., Tercelj, K., Manca, E., Candido, R., Tommasi, E., Tornese, G., Faleschini, E., Tonutti, L., Agus, S., Zanatta, M., Rosolen, A., Comici, A., Graziano, F. M., Misischi, I., Pozzilli, P., Maurizi, A. R., Falasca, P., Tuccinardi, F., Ricciardi, G. P., Di Masa, P., Ragonese, M., Cipolloni, L., Buzzetti, R., Moretti, C., Leto, G., Crino, A., Bocchini, S., Di Perna, P., Giuliano, M., Frontoni, S., Malandrucco, I., Pitocco, D., Scalpone, R., Toscanella, F., Cappa, M., Ventura, C., Bonato, V., De Bernardinis, M., Cavallo, M. G., Leonetti, F., Morano, S., Mandosi, E., Cicconetti, E., Ciampittiello, G., Marini, M. A., Sabato, D., Napoli, A., Giraudo, F., Toscano, V., Massimiani, F., Fava, D., Gargiulo, P., Mecca, N., Tubili, C., Nardone, M. R., Morviducci, L., Manca-Bitti, M. L., Arcano, S., Leotta, S., Suraci, C., Chiaramonte, F., Visalli, N., Forte, E., Palmacci, C., Arnaldi, C., Tosini, D., Querci, F., Trevisan, R., Bonfadini, S., Prandi, E., Felappi, B., Locatelli, F., Fuso, V., Rocca, A., Meneghini, E., Massafra, C., Terni, T., Elli, P., Ruggeri, P., Carrai, E., Musacchio, N., Lovagnini Scher, C. A., Marelli, G., Vilei, V., Richini, D., Inversini, C., Franzetti, I., Bonacina, M., Ciucci, A., Sciangula, L., Duratorre, E., Bonomo, M., Bertuzzi, F., Chebat, E., Muratori, M., Scaramuzza, A., Zuccotti, G. V., Bollati, P. M., Colapinto, P., Orsi, E., Palmieri, E., Laurenzi, A., Molinari, C., Frontino, G., Veronelli, A., Zecchini, B., Bianchi, A., Torchio, G., Lovati, E., Ghilardi, G., Dagani, R., Carugo, D., Berra, C., Favacchio, G., Fochesato, E., Pissarelli, A., Bucciarelli, L., Bulgheroni, M., Guerraggio, L., Zonca, S., Bossi, A. C., Berzi, D., Mangone, I., Cazzaniga, E., Rabini, R. A., Boemi, M., Faloia, E., Boscaro, M., Sternari, G., Iannilli, A., Cherubini, V., Busciantella Ricci, N., Cartechini, M. G., Tesei, A. M., Maolo, G., Galetta, M., Vespasiani, G., Tinti, G., Manfrini, S., Aiello, A., Di Vincenzo, S., Vitale, C., Di Caro, P., Lera, R., Secco, A., Lesina, A., Romeo, F., Origlia, C., Giorda, C., Chiambretti, A. M., Fornengo, R., De Donno, V., Gallarotti, F., Manti, R., Marafetti, L., Cadario, F., Savastio, S., Barbieri, P., Massucco, P., Ali, A., Gottero, C., Degiovanni, M., Bertaina, S., Maghenzani, G., Tinti, D., Fontana, F., Giorgino, F., Stefanelli, G., Cavallo, L., Zecchino, C., Piccinno, E., Ortolani, F., Gallo, F., Moramarco, F., Marino, A., Sparasci, G., Mileti, G., Lamacchia, O., Picca, G., Coccioli, M. S., Micale, F., Serra, R., Romano, I., Savino, T., De Cosmo, S., Rauseo, A., Delvecchio, M., Lapolla, R., Braione, A. F., Papagno, G., Baroni, M., Melis, M., Cossu, E., Songini, M., Cambuli, V. M., Lo Presti, D., Timpanaro, T. A., Chiavetta, A., Garofalo, M. R., Tommaselli, L., Tumminia, A., Scarpitta, A. M., Di Benedetto, A., Giunta, L., Lombardo, F., Salzano, G., Cardella, F., Roppolo, R., Provenzano, V., Fleres, M., Migliorini, S., De Luca, A., Leopardi, A., Beltrami, C., Toni, S., Guasti, G., Lenzi, L., Lamanna, C., Mannucci, E., Lucchesi, S., Dicianni, G., Aragona, M., Del Prato, S., Fattor, B., Eisath, J., Pasquino, B., Reinstadler, P., Kaufmann, P., Incelli, G., Rauch, S., Romanelli, T., Cauvin, V., Franceschi, R., Soldani, C., Scattoni, R., Norgiolini, R., Celleno, R., Torlone, E., Bolli, G. B., Lalli, C., Scarponi, M., Bobbio, A., Bechaz, M., Pianta, A., Marangoni, A., Arico, C. N., Alagona, C., Confortin, L., Rossi, E., Boscolo Bariga, A., Nogara, A., Bettio, M., Frison, V., Guidoni, G. L., Fongher, C., Contin, M. L., Cosma, A., Vianello, S., Bondesan, L., Morea, A., Volpi, A., Coracina, A., Panebianco, G., Lombardi, S., Costa, S., Cipponeri, E., Vedovato, M., Scotton, R., Monciotti, C. M., Galderisi, A., Dalfra, M. G., Lapolla, A., Zanon, M., Lisato, G., Mollo, F., Calcaterra, F., Miola, M., Paccagnella, A., Sambataro, M., Moro, E., Trombetta, M., Negri, C., Sabbion, A., Maffeis, C., Strazzabosco, M., Mesturino, C. A., Mingardi, R., Bruttomesso, D, Laviola, L, Lepore, G, Bonfanti, R, Bozzetto, L, Corsi, A, Di Blasi, V, Girelli, A, Grassi, G, Iafusco, D, Rabbone, I, Schiaffini, R, Montani, V, Colleluori, P, Paciotti, V, Alfidi, P, Grosso, J, Tumini, S, Cipriano, P, Vitacolonna, E, Di Vieste, G, Minnucci, A, Antenucci, D, La Penna, G, Taraborrelli, M, Macerala, B, Citro, G, De Morelli, G, Gnasso, A, Irace, C, Citriniti, F, Lazzaro, N, Bruzzese, M, Mammi, F, De Berardinis, F, Santoro, E, Corigliano, G, Corigliano, M, Parillo, M, Schettino, M, Fresa, R, Annuzzi, G, Bassi, V, Santinelli, C, Buono, P, Mozzillo, E, De Feo, E, Esposito, K, Petrizzo, M, Foglia, A, Gatti, A, Gentile, S, Guarino, G, Zanfardino, A, Lambiase, C, Vitale, A, Zucchini, S, Maltoni, G, Forlani, G, Moscatiello, S, Suprani, T, Bensa, M, Tomasi, F, Monesi, M, Nizzoli, M, Acquati, S, Chierici, G, Milli, B, Iughetti, L, Predieri, B, Cavani, R, Romano, S, Manicardi, V, Michelini, M, Cimicchi, M, Ugolotti, D, Zavaroni, I, Dei Cas, A, Dall'Aglio, E, Papi, M, Tardio, S, Calderini, M, Riboni, S, D'Amato, L, Zavaroni, D, Gastaldi, L, Di Bartolo, P, Pellicano, F, Cirillo, A, Graziani, V, Di Secli, C, Amarri, S, Lasagni, A, Marsciani, A, Pedini, A, Pagliani, U, Rossi, C, Tortul, C, Brunato, B, Assaloni, R, Zanette, G, Livolsi, P, Petrucco, A, Tercelj, K, Manca, E, Candido, R, Tommasi, E, Tornese, G, Faleschini, E, Tonutti, L, Agus, S, Zanatta, M, Rosolen, A, Comici, A, Graziano, F, Misischi, I, Pozzilli, P, Maurizi, A, Falasca, P, Tuccinardi, F, Ricciardi, G, Di Masa, P, Ragonese, M, Cipolloni, L, Buzzetti, R, Moretti, C, Leto, G, Crino, A, Bocchini, S, Di Perna, P, Giuliano, M, Frontoni, S, Malandrucco, I, Pitocco, D, Scalpone, R, Toscanella, F, Cappa, M, Ventura, C, Bonato, V, De Bernardinis, M, Cavallo, M, Leonetti, F, Morano, S, Mandosi, E, Cicconetti, E, Ciampittiello, G, Marini, M, Sabato, D, Napoli, A, Giraudo, F, Toscano, V, Massimiani, F, Fava, D, Gargiulo, P, Mecca, N, Tubili, C, Nardone, M, Morviducci, L, Manca-Bitti, M, Arcano, S, Leotta, S, Suraci, C, Chiaramonte, F, Visalli, N, Forte, E, Palmacci, C, Arnaldi, C, Tosini, D, Querci, F, Trevisan, R, Bonfadini, S, Prandi, E, Felappi, B, Locatelli, F, Fuso, V, Rocca, A, Meneghini, E, Massafra, C, Terni, T, Elli, P, Ruggeri, P, Carrai, E, Musacchio, N, Lovagnini Scher, C, Marelli, G, Vilei, V, Richini, D, Inversini, C, Franzetti, I, Bonacina, M, Ciucci, A, Sciangula, L, Duratorre, E, Bonomo, M, Bertuzzi, F, Chebat, E, Muratori, M, Scaramuzza, A, Zuccotti, G, Bollati, P, Colapinto, P, Orsi, E, Palmieri, E, Laurenzi, A, Molinari, C, Frontino, G, Veronelli, A, Zecchini, B, Bianchi, A, Torchio, G, Lovati, E, Ghilardi, G, Dagani, R, Carugo, D, Berra, C, Favacchio, G, Fochesato, E, Pissarelli, A, Bucciarelli, L, Bulgheroni, M, Guerraggio, L, Zonca, S, Bossi, A, Berzi, D, Mangone, I, Cazzaniga, E, Rabini, R, Boemi, M, Faloia, E, Boscaro, M, Sternari, G, Iannilli, A, Cherubini, V, Busciantella Ricci, N, Cartechini, M, Tesei, A, Maolo, G, Galetta, M, Vespasiani, G, Tinti, G, Manfrini, S, Aiello, A, Di Vincenzo, S, Vitale, C, Di Caro, P, Lera, R, Secco, A, Lesina, A, Romeo, F, Origlia, C, Giorda, C, Chiambretti, A, Fornengo, R, De Donno, V, Gallarotti, F, Manti, R, Marafetti, L, Cadario, F, Savastio, S, Barbieri, P, Massucco, P, Ali, A, Gottero, C, Degiovanni, M, Bertaina, S, Maghenzani, G, Tinti, D, Fontana, F, Giorgino, F, Stefanelli, G, Cavallo, L, Zecchino, C, Piccinno, E, Ortolani, F, Gallo, F, Moramarco, F, Marino, A, Sparasci, G, Mileti, G, Lamacchia, O, Picca, G, Coccioli, M, Micale, F, Serra, R, Romano, I, Savino, T, De Cosmo, S, Rauseo, A, Delvecchio, M, Lapolla, R, Braione, A, Papagno, G, Baroni, M, Melis, M, Cossu, E, Songini, M, Cambuli, V, Lo Presti, D, Timpanaro, T, Chiavetta, A, Garofalo, M, Tommaselli, L, Tumminia, A, Scarpitta, A, Di Benedetto, A, Giunta, L, Lombardo, F, Salzano, G, Cardella, F, Roppolo, R, Provenzano, V, Fleres, M, Migliorini, S, De Luca, A, Leopardi, A, Beltrami, C, Toni, S, Guasti, G, Lenzi, L, Lamanna, C, Mannucci, E, Lucchesi, S, Dicianni, G, Aragona, M, Del Prato, S, Fattor, B, Eisath, J, Pasquino, B, Reinstadler, P, Kaufmann, P, Incelli, G, Rauch, S, Romanelli, T, Cauvin, V, Franceschi, R, Soldani, C, Scattoni, R, Norgiolini, R, Celleno, R, Torlone, E, Bolli, G, Lalli, C, Scarponi, M, Bobbio, A, Bechaz, M, Pianta, A, Marangoni, A, Arico, C, Alagona, C, Confortin, L, Rossi, E, Boscolo Bariga, A, Nogara, A, Bettio, M, Frison, V, Guidoni, G, Fongher, C, Contin, M, Cosma, A, Vianello, S, Bondesan, L, Morea, A, Volpi, A, Coracina, A, Panebianco, G, Lombardi, S, Costa, S, Cipponeri, E, Vedovato, M, Scotton, R, Monciotti, C, Galderisi, A, Dalfra, M, Lapolla, A, Zanon, M, Lisato, G, Mollo, F, Calcaterra, F, Miola, M, Paccagnella, A, Sambataro, M, Moro, E, Trombetta, M, Negri, C, Sabbion, A, Maffeis, C, Strazzabosco, M, Mesturino, C, Mingardi, R, Bruttomesso, Daniela, Laviola, Luigi, Lepore, Giuseppe, Bonfanti, Riccardo, Bozzetto, Lutgarda, Corsi, Andrea, Di Blasi, Vincenzo, Girelli, Angela, Grassi, Giorgio, Iafusco, Dario, Rabbone, Ivana, Schiaffini, Riccardo, and Tornese, Gianluca
- Subjects
Blood Glucose ,Male ,Pediatrics ,Glucose control ,IMPACT ,Cost-Benefit Analysis ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,CHILDREN ,Practice Patterns ,Infusions, Subcutaneous ,law.invention ,Settore MED/13 ,Endocrinology ,Randomized controlled trial ,law ,Surveys and Questionnaires ,Insulin ,Practice Patterns, Physicians' ,Child ,Adult ,Diabetes Mellitus, Type 1 ,Female ,Guideline Adherence ,Health Care Surveys ,Humans ,Hypoglycemic Agents ,Italy ,Medical Laboratory Technology ,Medicine (all) ,PUMP THERAPY ,Subcutaneous ,Diabetes ,Diabetes and Metabolism ,TERM METABOLIC-CONTROL ,Human ,Type 1 ,Infusions ,medicine.medical_specialty ,Keywords KeyWords Plus:TERM METABOLIC-CONTROL ,BOLUS CALCULATOR ,PEDIATRIC-PATIENTS ,CONTROLLED-TRIAL ,CSII ,Diabetes mellitus ,Diabetes Mellitus ,medicine ,term metabolic-control ,bolus calculator ,pump therapy ,pediatric-patients ,controlled-trial ,children ,impact CSII ,Glucose sensors ,Cost-Benefit Analysi ,Intensive care medicine ,Type 1 diabetes ,Physicians' ,Hypoglycemic Agent ,business.industry ,medicine.disease ,Subcutaneous insulin ,Infusions, Subcutaneou ,Multicenter study ,Health Care Survey ,business - Abstract
Background: Continuous subcutaneous insulin infusion (CSII) is increasing worldwide, mostly because of improved technology. The aim of this study was to evaluate the current status of CSII in Italy. Materials and Methods: Physicians from 272 diabetes centers received a questionnaire investigating clinical features, pump technology, and management of patients on CSII. Results: Two hundred seventeen centers (79.8%) joined the study and, by the end of April 2013, gave information about 10,152 patients treated with CSII: 98.2% with type 1 diabetes mellitus, 81.4% adults, 57% female, and 61% with a conventional pump versus 39% with a sensor-augmented pump. CSII advanced functions were used by 68% of patients, and glucose sensors were used 12 days per month on average. Fifty-eight percent of diabetes centers had more than 20 patients on CSII, but there were differences among centers and among regions. The main indication for CSII was poor glucose control. Dropout was mainly due to pump wearability or nonoptimal glycemic control. Twenty-four hour assistance was guaranteed in 81% of centers. A full diabetes team (physician+ nurse + dietician + psychologist) was available in 23% of adult-care diabetes centers and in 53%of pediatric diabetes units. Conclusions: CSII keeps increasing in Italy. More work is needed to ensure uniform treatment strategies throughout the country and to improve pump use.
- Published
- 2015
23. No beta cell desensitisation after a median of 68 months on glibenclamide therapy in patients with KCNJ11-associated permanent neonatal diabetes
- Author
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Iafusco, D., Bizzarri, C., Cadario, F., Pesavento, R., Tonini, G., Tumini, S., Cauvin, V., Colombo, C., Bonfanti, R., and Barbetti, F.
- Published
- 2011
- Full Text
- View/download PDF
24. Antibodies to tissue transglutaminase C in Type I diabetes
- Author
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Lampasona, V., Bonfanti, R., Bazzigaluppi, E., Venerando, A., Chiumello, G., Bosi, E., and Bonifacio, E.
- Published
- 1999
- Full Text
- View/download PDF
25. INTEGRATED REAL-TIME CONTINUOUS GLUCOSE MONITORING/INSULIN PUMP SYSTEM (PRT) USEFULNESS IN 122 CHILDREN WITH TYPE 1 DIABETES: A 3-YEAR FOLLOW-UP STUDY: OP05
- Author
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Scaramuzza, A, Bonfanti, R, Buono, P, Iafusco, D, Lombardo, F, Rabbone, I, Schiaffini, R, Sulli, N, Toni, S, Giani, E, Pivetti, V, and Zuccotti, G V
- Published
- 2010
26. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study
- Author
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Bowman P., Sulen A., Barbetti F., Beltrand J., Svalastoga P., Codner E., Tessmann E. H., Juliusson P. B., Skrivarhaug T., Pearson E. R., Flanagan S. E., Babiker T., Thomas N. J., Shepherd M. H., Ellard S., Klimes I., Szopa M., Polak M., Iafusco D., Hattersley A. T., Njolstad P. R., Aisenberg J., Akkurt I., Abdul-Latif H., Al-Abdullah A., Barak L., Van Den Bergh J., Bertrand A. -M., Bizzarri C., Bonfanti R., Bruel H., Burrows A., Cadario F., Cameron F. J., Carson D., Cartigny M., Cauvin V., Cave H., Chakera A., Chetan R., Chiari G., Couch B., Coutant R., Cummings E., Dankovcikova A., Davis L., Deiss D., Delvecchio M., Faleschini E., Fauret A. -L., Finn R., Ford T., Franco E. D., Gallen B. D., Gasperikova D., Guntamukkala P., Hakeem V., Hasegawa S., Hathout E. H., Heffernan E., Hill D., Ho J., Hoarau M., Holl R., Hoddinott R., Houghton J., Howard N., Hughes N., Hunter I., Hogasen A. K., Kuulasmaa H., Ioacara S., Iotova V., Irgens H., Jaap A., Jones K., Kapellen T., Kaufman E., Klinge A., Klupa T., Krishnaswamy R., Lafferty T., LeGault L., Lambert P., Malecki M. T., Malievsky O., Mathew R., Mathews F., McVie R., Menzel U., Metz C., Meulen J. V. D., Modgil G., Mul D., Muther S., Nuboer R., O'Connell S. M., O'Riordan S., Palko M., Patel K. A., Pesavento R., Piccinno E., Pillai J. K., Pruhova S., Punthakee Z., Rabbone I., Raile K., Rincon M., Rose D., Sanchez J., Sandereson S., Saxena V., Schebek M., Schmidt D., Shehadeh N., Shiels J. P. H., Silva J. M. C. L., Stanik J., Tinklin T., Tjora E., Tumini S., Tuomi T., Uehara A., Velde R. V. D., Vermeulen G., Visser U., Voorhoeve P., Walker J., Weill J., Weisner T., Werner A., Williams T., Woodhead H., oddegard R., Bowman, Pamela, Sulen, Åsta, Barbetti, Fabrizio, Beltrand, Jacque, Svalastoga, Pernille, Codner, Ethel, Tessmann, Ellen H, Juliusson, Petur B, Skrivarhaug, Torild, Pearson, Ewan R, Flanagan, Sarah E, Babiker, Tarig, Thomas, Nicholas J, Shepherd, Maggie H, Ellard, Sian, Klimes, Iwar, Szopa, Magdalena, Polak, Michel, Iafusco, Dario, Hattersley, Andrew T, Njølstad, Pål R, Aisenberg, Javier, Akkurt, Ilker, Abdul-Latif, Hussein, Al-Abdullah, Anee, Barak, Lubomir, Van Den Bergh, Joop, Bertrand, Anne-Marie, Bizzarri, Carla, Bonfanti, Riccardo, Bruel, Henri, Burrows, Anthony, Cadario, Francesco, Cameron, Fergus J., Carson, Denni, Cartigny, Maryse, Cauvin, Vittoria, Cave, Helene, Chakera, Ali, Chetan, Ravi, Chiari, Giovanni, Couch, Bob, Coutant, Régi, Cummings, Elizabeth, Dankovcikova, Adriana, Davis, Liz, Deiss, Dorothee, Delvecchio, Maurizio, Faleschini, Elena, Fauret, Anne-Laure, Finn, Roisin, Ford, Tamsin, Franco, Elisa De, Gallen, Bastian De, Gasperíková, Daniela, Guntamukkala, Padma, Hakeem, Vaseem, Hasegawa, Shinji, Hathout, Eba H., Heffernan, Emmeline, Hill, David, Ho, Josephine, Hoarau, Marie, Holl, Reinhard, Hoddinott, Rebecca, Houghton, Jane, Howard, Neville, Hughes, Natalie, Hunter, Ian, Høgåsen, Anne Kirsti, Kuulasmaa, Helena, Iocara, Sorin, Iotova, Violeta, Irgens, Henrik, Jaap, Alan, Jones, Kenneth, Kapellen, Thoma, Kaufman, Ellen, Klinge, Andrea, Klupa, Tomasz, Krishnaswamy, Ramaiyer, Lafferty, Tony, Legault, Laurent, Lambert, Paul, Malecki, Maciej T, Malievsky, Olag, Mathew, Revi, Mathews, France, Mcvie, Robert, Menzel, Ulrike, Metz, Chantale, Meulen, John Van Der, Modgil, Gita, Mul, Dick, Muther, Silvia, Nuboer, Roo, O'Connell, Susan M., O'Riordan, Stephen, Palko, Miroslav, Patel, Kashyap Amratlal, Pesavento, Roberta, Piccinno, Elvira, Pillai, Janani Kumaraguru, Pruhova, Stephanka, Punthakee, Zubin, Rabbone, Ivana, Raile, Klemen, Rincon, Marielisa, Rose, Danette, Sanchez, Janine, Sandereson, Susan, Saxena, Vinay, Schebek, Martin, Schmidt, Dorothee, Shehadeh, Naim, Shiels, Julian P. H., Silva, Jose M. C. L, Stanik, Juraj, Tinklin, Tracy, Tjora, Erling, Tumini, Stefano, Tuomi, Tiinamaija, Uehara, Akiko, Velde, Robert Van der, Vermeulen, Guido, Visser, Uma, Voorhoeve, Paul, Walker, Jan, Weill, Jaque, Weisner, Tobia, Werner, Andrea, Williams, Toni, Woodhead, Helen, Øddegård, Rønnaug, Bowman, P., Sulen, A., Barbetti, F., Beltrand, J., Svalastoga, P., Codner, E., Tessmann, E. H., Juliusson, P. B., Skrivarhaug, T., Pearson, E. R., Flanagan, S. E., Babiker, T., Thomas, N. J., Shepherd, M. H., Ellard, S., Klimes, I., Szopa, M., Polak, M., Iafusco, D., Hattersley, A. T., Njolstad, P. R., Aisenberg, J., Akkurt, I., Abdul-Latif, H., Al-Abdullah, A., Barak, L., Van Den Bergh, J., Bertrand, A. -M., Bizzarri, C., Bonfanti, R., Bruel, H., Burrows, A., Cadario, F., Cameron, F. J., Carson, D., Cartigny, M., Cauvin, V., Cave, H., Chakera, A., Chetan, R., Chiari, G., Couch, B., Coutant, R., Cummings, E., Dankovcikova, A., Davis, L., Deiss, D., Delvecchio, M., Faleschini, E., Fauret, A. -L., Finn, R., Ford, T., Franco, E. D., Gallen, B. D., Gasperikova, D., Guntamukkala, P., Hakeem, V., Hasegawa, S., Hathout, E. H., Heffernan, E., Hill, D., Ho, J., Hoarau, M., Holl, R., Hoddinott, R., Houghton, J., Howard, N., Hughes, N., Hunter, I., Hogasen, A. K., Kuulasmaa, H., Ioacara, S., Iotova, V., Irgens, H., Jaap, A., Jones, K., Kapellen, T., Kaufman, E., Klinge, A., Klupa, T., Krishnaswamy, R., Lafferty, T., Legault, L., Lambert, P., Malecki, M. T., Malievsky, O., Mathew, R., Mathews, F., Mcvie, R., Menzel, U., Metz, C., Meulen, J. V. D., Modgil, G., Mul, D., Muther, S., Nuboer, R., O'Connell, S. M., O'Riordan, S., Palko, M., Patel, K. A., Pesavento, R., Piccinno, E., Pillai, J. K., Pruhova, S., Punthakee, Z., Rabbone, I., Raile, K., Rincon, M., Rose, D., Sanchez, J., Sandereson, S., Saxena, V., Schebek, M., Schmidt, D., Shehadeh, N., Shiels, J. P. H., Silva, J. M. C. L., Stanik, J., Tinklin, T., Tjora, E., Tumini, S., Tuomi, T., Uehara, A., Velde, R. V. D., Vermeulen, G., Visser, U., Voorhoeve, P., Walker, J., Weill, J., Weisner, T., Werner, A., Williams, T., Woodhead, H., and Oddegard, R.
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Background: KCNJ11 mutations cause permanent neonatal diabetes through pancreatic ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to oral sulfonylureas with excellent initial glycaemic control; however, whether this control is maintained in the long term is unclear. Sulfonylurea failure is seen in about 44% of people with type 2 diabetes after 5 years of treatment. Therefore, we did a 10-year multicentre follow-up study of a large international cohort of patients with KCNJ11 permanent neonatal diabetes to address the key questions relating to long-term efficacy and safety of sulfonylureas in these patients. Methods: In this multicentre, international cohort study, all patients diagnosed with KCNJ11 permanent neonatal diabetes at five laboratories in Exeter (UK), Rome (Italy), Bergen (Norway), Paris (France), and Krakow (Poland), who transferred from insulin to oral sulfonylureas before Nov 30, 2006, were eligible for inclusion. Clinicians collected clinical characteristics and annual data relating to glycaemic control, sulfonylurea dose, severe hypoglycaemia, side-effects, diabetes complications, and growth. The main outcomes of interest were sulfonylurea failure, defined as permanent reintroduction of daily insulin, and metabolic control, specifically HbA 1c and sulfonylurea dose. Neurological features associated with KCNJ11 permanent neonatal diabetes were also assessed. This study is registered with ClinicalTrials.gov, number NCT02624817. Findings: 90 patients were identified as being eligible for inclusion and 81 were enrolled in the study and provided long-term (>5·5 years cut-off) outcome data. Median follow-up duration for the whole cohort was 10·2 years (IQR 9·3–10·8). At most recent follow-up (between Dec 1, 2012, and Oct 4, 2016), 75 (93%) of 81 participants remained on sulfonylurea therapy alone. Excellent glycaemic control was maintained for patients for whom we had paired data on HbA 1c and sulfonylurea at all time points (ie, pre-transfer [for HbA 1c ], year 1, and most recent follow-up; n=64)—median HbA 1c was 8·1% (IQR 7·2–9·2; 65·0 mmol/mol [55·2–77·1]) before transfer to sulfonylureas, 5·9% (5·4–6·5; 41·0 mmol/mol [35·5–47·5]; p
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- 2018
27. Residual beta-cell function and spontaneous clinical remission in type 1 diabetes mellitus: the role of puberty
- Author
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Bonfanti, R., Bognetti, E., Meschi, F., Brunelli, A., Riva, M. C., Pastore, M. R., Calori, G., and Chiumello, G.
- Published
- 1998
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28. Mutations in IAPP and NEUROG3 genes are not a common cause of permanent neonatal/infancy/childhood-onset diabetes
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Nocerino, V., Colombo, C., Bonfanti, R., Iafusco, D., and Barbetti, F.
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- 2009
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- View/download PDF
29. Bone Modeling Indexes at Onset and During the First Year of Follow-Up in Insulin-Dependent Diabetic Children
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Bonfanti, R., Mora, S., Prinster, C., Bognetti, E., Meschi, F., Puzzovio, M., Proverbio, M. C., and Chiumello, G.
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- 1997
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30. Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM
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Genovese, S., Bonfanti, R., Bazzigaluppi, E., Lampasona, V., Benazzi, E., Bosi, E., Chiumello, G., and Bonifacio, E.
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- 1996
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31. Association of interferon-γ and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes
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Alizadeh, B. Z., Hanifi-Moghaddam, P., Eerligh, P., van der Slik, A. R., Kolb, H., Kharagjitsingh, A. V., Arias, A. M. Pereira, Ronkainen, M., Knip, M., Bonfanti, R., Bonifacio, E., Devendra, D., Wilkin, T., Giphart, M. J., Koeleman, B. P. C., Nolsøe, R., Poulsen, T. Mandrup, Schloot, N. C., and Roep, B. O.
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- 2006
32. Insulin resistance and whole body energy homeostasis in obese adolescents with fatty liver disease: 019
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Bonfanti, R., Perseghin, G., Magni, S., De Cobelli, F., Canu, T., Scifo, P., Del Maschio, A., Luzi, L., and Chiumello, G.
- Published
- 2006
33. Insulin pump failures in Italian children with Type 1 diabetes: retrospective 1-year cohort study
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Rabbone, I., Minuto, N., Bonfanti, R., Marigliano, M., Cerutti, F., Cherubini, V., d(')Annunzio, G., Frongia, A. P., Iafusco, D., Ignaccolo, G., Lombardo, F., Schiaffini, R., Toni, S., Tumini, S., Zucchini, S., Pistorio, A., Scaramuzza, A. E., Scaramuuzza, A. E., Lera, R., Secco, A., Bobbio, A., Bechaz, M., Piccinno, E., Natale, M. P., Ortolani, F., Zecchino, C., Lonero, A., Maltoni, G., Pasquino, B., Gallo, F., Frongia, P., Ripoli, C., Lo Presti, D., Timpanaro, T., Citriniti, F., Suprani, T., Carinci, S., Cipriano, P., Lazzaro, N., De Donno, V., Gallarotti, F., Lenzi, L., Piccini, B., Vittorio, L., Russo, C., Borea, R., Mamm(`i), F., Bruzzese, M., Ventrici, C., Salzano, G., Frontino, G., Bonura, C., Favalli, V., Scaramuzza, A., Zuccotti, G. V., Ferrari, M., Iughetti, L., Predieri, B., Franzese, A., Mozzillo, E., Buono, P., Confetto, S., Zanfardino, A., Cadario, F., Savastio, S., Fiorito, C., Barbieri, P., Piredda, G., Cardella, F., Ropolo, R., Federico, G., Marchi, B., Benevento, D., Carducci, C., Mancabitti, M. L., Delvecchio, M., Lapolla, R., Gaiero, A., Fichera, G., Ignaccolo, M. G., Tinti, D., Cauvin, V., Franceschi, R., Biagioni, M., Salvatoni, A., Scolari, A., Maffeis, C., Sabbion, A., Arnaldi, C., Tosini, D., Rabbone, I, Minuto, N., Bonfanti, R., Marigliano, M., Cerutti, F., Cherubini, V., D'Annunzio, G., Frongia, A. P., Iafusco, Dario, Ignaccolo, G., Lombardo, F., Schiaffini, R., Toni, S., Tumini, S., Zucchini, S., Pistorio, A., Scaramuzza, A. E., Rabbone, I., Iafusco, D., Lera, R., Secco, A., Bobbio, A., Bechaz, M., Piccinno, E., Natale, M. P., Ortolani, F., Zecchino, C., Lonero, A., Maltoni, G., Pasquino, B., Gallo, F., Frongia, P., Ripoli, C., Lo Presti, D., Timpanaro, T., Citriniti, F., Suprani, T., Carinci, S., Cipriano, P., Lazzaro, N., De Donno, V., Gallarotti, F., Lenzi, L., Piccini, B., Vittorio, L., Russo, C., Borea, R., Mammi, F., Bruzzese, M., Ventrici, C., Salzano, G., Frontino, G., Bonura, C., Favalli, V., Scaramuzza, A., Zuccotti, G. V., Ferrari, M., Iughetti, L., Predieri, B., Franzese, A., Mozzillo, E., Buono, P., Confetto, S., Zanfardino, A., Cadario, F., Savastio, S., Fiorito, C., Barbieri, P., Piredda, G., Cardella, F., Ropolo, R., Federico, G., Marchi, B., Benevento, D., Carducci, C., Mancabitti, M. L., Del Vecchio, M., Lapolla, R., Gaiero, A., Fichera, G., Ignaccolo, M. G., Tinti, D., Cauvin, V., Franceschi, R., Biagioni, M., Salvatoni, A., Scolari, A., Maffeis, C., Sabbion, A., Arnaldi, C., Tosini, D., Rabbone, Minuto, Mammì, F., and Mozzillo, Enza.
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Blood Glucose ,Male ,Pediatrics ,Adolescent ,Blood Glucose Self-Monitoring ,Child ,Child, Preschool ,Diabetes Mellitus, Type 1 ,Equipment Failure ,Female ,Humans ,Infant ,Insulin ,Italy ,Retrospective Studies ,Insulin Infusion Systems ,type 1 diabetes ,medicine.medical_treatment ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,Endocrinology ,0302 clinical medicine ,Retrospective Studie ,Medicine ,030212 general & internal medicine ,Diabetes ,Diabetology ,failure ,Diabetes and Metabolism ,children and adolescents ,insulin pump ,Cohort study ,Type 1 ,Human ,Insulin pump ,medicine.medical_specialty ,Disease duration ,030209 endocrinology & metabolism ,03 medical and health sciences ,Diabetes mellitus ,Diabetes Mellitus ,Preschool ,Type 1 diabetes ,business.industry ,Diabetes, Type1, Pump, Insulin ,Type1 ,Retrospective cohort study ,Pump ,medicine.disease ,Surgery ,Insulin Infusion System ,business - Abstract
Aims Insulin pump failure and/or malfunction requiring replacement have not been thoroughly investigated. This study evaluated pump replacement in children and adolescents with Type 1 diabetes using insulin pump therapy. Methods Data were collected for all participants younger than 19 years, starting insulin pump therapy before 31 December 2013. For each child, age, disease duration, date of insulin pump therapy initiation, insulin pump model, failure/malfunction/replacement yes/no and reason were considered for the year 2013. Results Data were returned by 40 of 43 paediatric centres belonging to the Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetology. In total, 1574 of 11 311 (13.9%) children and adolescents with Type 1 diabetes were using an insulin pump: 29.2% Animas VIBE™, 9.4% Medtronic MiniMed 715/515™, 34.3% Medtronic MiniMed VEO™, 24.3% Accu-Check Spirit Combo™ and 2.8% other models. In 2013, 0.165 insulin pump replacements per patient-year (11.8% due to pump failure/malfunction and 4.7% due to accidental damage) were recorded. Animas VIBE™ (22.1%) and Medtronic MiniMed VEO™ (17.7%) were the most replaced. Conclusions In a large cohort of Italian children and adolescents with Type 1 diabetes, insulin pump failure/malfunction and consequent replacement are aligned with rates previously reported and higher in more sophisticated pump models. This article is protected by copyright. All rights reserved.
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- 2017
34. Is Fat Mass Accretion of Late Preterm Infants Associated with Insulin Resistance?
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Liotto N., Gianni M. L., Taroni F., Roggero P., Condello C. C., Orsi A., Menis C., Bonfanti R., Mosca F., Liotto, N., Gianni, M. L., Taroni, F., Roggero, P., Condello, C. C., Orsi, A., Menis, C., Bonfanti, R., and Mosca, F.
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Late preterm infants ,Fat mass ,Insulin - Abstract
Background: Late preterm infants show a major fat mass accretion from birth to term. The contribution of preterm birth to the development of the metabolic syndrome is still under investigation. Objectives: To evaluate body composition changes in late preterm infants during the first 3 months and to investigate their insulin sensitivity and resistance. Methods: We conducted an observational, longitudinal study. A total of 216 late preterm infants underwent body composition assessment using an air displacement plethysmograph at term and at 3 months of corrected age. In a subgroup of infants (n = 48) the blood glucose and insulin concentration were determined at term and insulin resistance (homeostasis model assessment for insulin resistance; HOMA-IR) and sensitivity (quantitative insulin sensitivity check index; QUICKI) were then calculated. The reference group comprised 71 healthy term infants. Results: The mean birth weight and gestational age were 2,390 ± 391 g and 35.2 ± 0.8 weeks, respectively. At term the fat mass index (kg/m2) of late preterm infants, born adequate for their gestational age and small for their gestational age, was higher than that of term infants (2.08 ± 0.82 vs. 1.62 ± 0.64 vs. 1.03 ± 0.36, p < 0.005, respectively), whereas at 3 months of corrected age no difference was found among the groups. The mean values of glucose, insulin, HOMA-IR, and QUICKI were within the 5th and 95th percentiles. Conclusions: On the basis of these preliminary findings, fat mass accretion of late preterm infants appears not to be associated with perturbation of the glucose homeostasis.
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- 2017
35. Growth and autoantibodies to IA-2 in children with type 1 diabetes
- Author
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Cianfarani, S, Bonfanti, R, Manca Bitti, M L, Chiumello, G, and Boscherini, B
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- 2000
36. Frequency and correlates of severe hypoglycaemia in children and adolescents with diabetes mellitus
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Bognetti, E., Brunelli, A., Meschi, F., Viscardi, M., Bonfanti, R., and Chiumello, G.
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- 1997
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- View/download PDF
37. Effects of drug-loaded nanostructured lipid carrier on glioblastoma cell cultures investigated by delayed luminescence spectroscopy
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Grasso, R., Campisi, A., Gulino, M., Bonfanti, R., Carbone, C., Puglisi, G., Musumeci, F., and Scordino, Agata
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mithocondria functionality ,nanoparticles lipid carrier ,apoptosis ,Delayed Luminescence - Published
- 2018
38. Nicotinamide and insulin secretion in normal subjects
- Author
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Bingley, P. J., Caldas, G., Bonfanti, R., and Gale, E. A. M.
- Published
- 1993
- Full Text
- View/download PDF
39. PUMP FAILURE AND MALFUNCTIONS IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES IN INSULIN PUMP THERAPY: AN ITALIAN PROSPECTIVE STUDYin 9th International Conference on Advanced Technologies & Treatment of Diabetes (ATTD) Barcellona 2016
- Author
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Rabbone I., Minuto N., Ignaccolo G., Bonfanti R., Iafusco D., Lombardo F., Cherubini V., Frongia A. P., Pistorio A., Marigliano M., Toni S., Scaramuzza A. E., P. F. Diabetes Study Group of ISPED, Rabbone, I., Minuto, N., Ignaccolo, G., Bonfanti, R., Iafusco, D., Lombardo, F., Cherubini, V., Frongia, A. P., Pistorio, A., Marigliano, M., Toni, S., Scaramuzza, A. E., and P. F., Diabetes Study Group of ISPED
- Abstract
Background and Aim: Current literature regarding insulin pump-associated adverse events including pump malfunction, infusion set/site issues is discussed. We evaluated metabolic and non–metabolic adverse events in a large cohort of children and adolescents with type 1 diabetes (T1D), using insulin pump therapy. Methods: Data have been collected on patients younger than 19 years, starting insulin pump therapy before December 31 2013. For each patient age, disease duration, date of insulin pump therapy initiation, insulin pump model, breakdown/malfunction/pump replacement yes/no and reason, catheter/infusion set failures have been considered prospectively for the calendar year 2014. Results: Data have been returned by 20 pediatric Centers belonging to the Italian Diabetes Study Group about 916 T1D children and adolescents using insulin pump. During 2014, the most frequent infusion set and site problems were bubbles (38.2%), kinking (13%), leakage (10.3%), tunneling (10.2%), blockage (8.8%), bleeding (11%), lipohypertrophy (7.1%), infection (1.4%). Pump device has been replaced in 19.2% of patients: 82% for pump breakdown/malfunctions and 18% for ‘physiologic’ replacement after warranty. HbA1C mean value was 7.6% for the whole population. No relationship between pump replacement and HbA1C value was found. Only 1 DKA has been recorded due to pump failure. No severe hypoglycemia has been recorded due to pump or infusion set malfunction. Conclusions: Despite frequent infusion set problems, pump breakdown/malfunction and consequent replacement and metabolic adverse events in a large cohort of pediatric Italian patients with T1D are not as frequent as previously reported. Continuous educational programs are necessary for pump therapy management.
- Published
- 2016
40. IMPROVEMENT OF THE CHILDREN POPULATION INCLUDED INTO THE UVA/PADOVA TYPE 1 DIABETES SIMULATOR in 9th International Conference on Advanced Technologies & Treatment of Diabetes - Barcellona 2016
- Author
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Visentin R., Man C. Dalla, Bonfanti R., Iafusco D., Schiaffini R., Rabbone I., Bruttomesso D., Cobelli C, Visentin, R., Man C., Dalla, Bonfanti, R., Iafusco, D., Schiaffini, R., Rabbone, I., Bruttomesso, D., and Cobelli, C
- Abstract
Background and Aims: The UVA/Padova Type 1 Diabetes Simulator (T1DMS) has proven to be very useful for the preclinical testing of control algorithms in adults, also thanks to the availability of data which allowed to refine and validate the in silico population. This facilitated several successful artificial pancreas inpatient and outpatient studies. Artificial pancreas studies in children are increasing and the T1DMS could play an important role in algorithmic development. The aim of this study is to assess and, if necessary, to update the in silico children included into the T1DMS. Method: The data set consisted of 13 T1DM prepubertals recruited among the centers of Milano, Napoli, Roma and Torino (Italy). Subjects wore a sensor-augmented insulin pump, and received a standardized breakfast (30g of carbohydrates [CHO]). The T1DMS model was identified from subcutaneous glucose sensor and insulin pump data using a Bayesian approach. Results: The model well fitted the data and provided precise estimates of model parameters. Our results suggest that meal glucose absorption is faster and insulin sensitivity lower, on average, than those included so far in the T1DMS (Figure 1). Based on these findings, a new children population was generated. The new T1DMS was then validated by comparing real vs simulated glucose curves in response to 30 g CHO meal: as a result, the new T1DMS well described the glucose variability observed in the data. Conclusion: The new in silico children population will enable a safer and effective preclinical testing of the closed-loop control in pediatric clinical trials.
- Published
- 2016
41. THE SOCIAL ACCEPTANCE OF FUTURE ARTIFICIAL PANCREAS TECHNOLOGY: PARENTS' PERCEPTIONS OF PEDARPAN (PEDIATRICS ARTIFICIAL PANCREAS) in 9th International Conference on Advanced Technologies & Treatment of Diabetes - Barcellona 2016
- Author
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Troncone A., Bonfanti R., Iafusco D., Rabbone I., Sabbion A., Schiaffini R., Galderisi A., Marigliano M., Rapini N., Rigamonti A., Tinti D., Vallone V., Zanfardino A., Boscari F., Del Favero S., Galasso S., Lanzola G., Messori M., Di Palma F., Visentin R., Calore R., Leal Y., Magni L., Losiouk E., Chernavvsky D., Quaglini S., Cobelli C., Bruttomesso D., Troncone, A., Bonfanti, R., Iafusco, D., Rabbone, I., Sabbion, A., Schiaffini, R., Galderisi, A., Marigliano, M., Rapini, N., Rigamonti, A., Tinti, D., Vallone, V., Zanfardino, A., Boscari, F., Del Favero, S., Galasso, S., Lanzola, G., Messori, M., Di Palma, F., Visentin, R., Calore, R., Leal, Y., Magni, L., Losiouk, E., Chernavvsky, D., Quaglini, S., Cobelli, C., and Bruttomesso, D.
- Abstract
Background and Aims: To explore the experiences of parents of 5–8-year-old children with type 1 diabetes participating in a clinical trial regarding artificial pancreas (AP), semistructured interviews, based on the Technology Acceptance Model, were conducted after 3 days of children's treatment. Method: Questions focused on evaluating parents' perceived usefulness of, perceived ease of use of, trust in, and intention to use the new system. Interviews were conducted by a psychologist, and the answers, both audiorecorded and transcribed verbatim, were assessed using qualitative research methods. Results: Altogether, 27 (22 mothers) of 30 parents were interviewed (Table 1), and their overall attitude toward AP was positive (96%). Perceived advantages included stable glucose regulation (52%), better quality of life for children (22%), relief of parents' daily concerns (15%), and reduced need for continual parental monitoring of nocturnal blood glucose (11%), while perceived disadvantages included having to constantly wear a bulky, heavy device (37%) and the risk of technical error (33%). Participants were mostly confident in the positive impact of AP on diabetes control (96%) and in children's, especially older ones', capability to use the system (55%). The reactions of teachers and friends were reported to be generally positive, though some parents (28%) expected an initially fearful reaction from teachers. Nearly all participants expressed trust in AP and in the quality of glucose control (96%), as well as the intention to use the new system when available (100%). Conclusion: Results indicate that, thanks to the psychological and physical benefits of AP, parents expressed a strong likelihood of future acceptance.
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- 2016
42. THE SOCIAL ACCEPTANCE OF FUTURE ARTIFICIAL PANCREAS TECHNOLOGY: PARENTS' PERCEPTIONS OF PEDARPAN (PEDIATRICS ARTIFICIAL PANCREAS)
- Author
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Troncone, A., Bonfanti, R., Iafusco, D., Rabbone, I., Sabbion, A., Schiaffini, R., Galderisi, A., Marigliano, M., Rapini, N., Rigamonti, A., Tinti, D., Vallone, V., Zanfardino, A., Boscari, F., Del Favero, S., Galasso, S., Lanzola, G., Messori, M., Di Palma, F., Visentin, R., Calore, R., Leal, Y., Magni, L., Eleonora Losiouk, Chernavvsky, D., Quaglini, S., Cobelli, C., Bruttomesso, D., Troncone, Alda, Bonfanti, R, Iafusco, Dario, Rabbone, I, Sabbion, A, Schiaffini, R, Galderisi, A, Marigliano, M, Rapini, N, Rigamonti, A, Tinti, D, Vallone, V, Zanfardino, A, Boscari, F, Del Favero, S, Galasso, S, Lanzola, G, Messori, M, Di Palma, F, Visentin, R, Calore, R, Leal, Y, Magni, L, Losiouk, E, Chernavvsky, D, Quaglini, S, Cobelli, C, and Bruttomesso, D.
- Published
- 2016
43. PERCEIVED UTILITY OF A REMOTE MONITORING SYSTEM FOR PEDIATRIC SUBJECTS AFFECTED BY TYPE 1 DIABETES IN PEDARPAN (PEDIATRICS ARTIFICIAL PANCREAS) SUMMER CAMP in 9th International Conference on Advanced Technologies & Treatment of Diabetes (ATTD) Barcellona 2016
- Author
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Losiouk E., Lanzola G., Bonfanti R., Iafusco D., Rabbone I., Sabbion A., Schiaffini R., Galderisi A., Marigliano M., Rapini N., Rigamonti A., Tinti D., Vallone V., Zanfardino A., Boscari F., Galasso S., Troncone A., Del Favero S., Visentin R., Calore R., Leal M. Y., Palma F. Di, Messori M., Chernavvsky D., Magni L., Bruttomesso D., Quaglini S., Cobelli C, Losiouk, E., Lanzola, G., Bonfanti, R., Iafusco, D., Rabbone, I., Sabbion, A., Schiaffini, R., Galderisi, A., Marigliano, M., Rapini, N., Rigamonti, A., Tinti, D., Vallone, V., Zanfardino, A., Boscari, F., Galasso, S., Troncone, A., Del Favero, S., Visentin, R., Calore, R., Leal, M. Y., Palma F., Di, Messori, M., Chernavvsky, D., Magni, L., Bruttomesso, D., Quaglini, S., and Cobelli, C
- Published
- 2016
44. EPIDEMIOLOGY OF INSULIN PUMP THERAPY IN ITALY: THE IMITAS STUDIES in 9th International Conference on Advanced Technologies & Treatment of Diabetes (ATTD) Barcellona 2016
- Author
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Bruttomesso D., Lepore G., Bonfanti R., Bozzetto L., Di Blasi V., Girelli A., Grassi G., Iafusco D., Rabbone I., Schiaffini R., Laviola L., Bruttomesso, D., Lepore, G., Bonfanti, R., Bozzetto, L., Di Blasi, V., Girelli, A., Grassi, G., Iafusco, D., Rabbone, I., Schiaffini, R., and Laviola, L.
- Abstract
Background: continuous subcutaneous insulin infusion (CSII) is increasing due to effectiveness and improved technology. Aim: to evaluate the current status of CSII in Italy. Materials and Methods: clinical features, pump technology, patient management and metabolic control of CSII patients were investigated in two questionnaire-based surveys to 272 Italian diabetes centers. Results: 217 centers (79,8%) answered the first questionnaire giving information on 10,152 patients, 98.2% with type 1 diabetes mellitus, 81,4% adults, 57% female, 61% with a conventional pump and 39% with a sensoraugmented pump. CSII advanced functions were used by 68% of patients, and glucose sensors were used 12 days/month on average. Fifty-eight percent of centers had >20 CSII patients. Main indication for CSII was poor glucose control. Dropout was mostly due to pump wearability or bad glucose control. A complete dedicated team was available in 23% of adult centers and in 53% of pediatric units. In the second survey, data were obtained from 114 centers on 6,886 patients with overall characteristics comparable to the previous one. Mean HbA1c was 60.1 ± 10.7 mM/M. Lower HbA1c levels were associated to age 6–13, pregnancy in the last year, use of advanced functions, sensor use ≥10 days/month, availability of a dedicated team. 6,1% of patients had ≥1 severe hypoglycemic event over the previous year. Conclusions: Advanced patient skills, compliance to sensor use and an integrated team approach are associated to better metabolic outcomes in Italian CSII patients.
- Published
- 2016
45. MULTI-CENTER RANDOMIZED CROSS-OVER ITALIAN PEDIATRIC SUMMER CAMP: AP VS SAP IN 5–9 YEAR OLD CHILDREN in 9th International Conference on Advanced Technologies & Treatment of Diabetes (ATTD) Barcellona 2016
- Author
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Del Favero S., Boscari F., Messori M., Rabbone I., Bonfanti R., Sabbion A., Iafusco D., Schiaffini R., Visentin R., Calore R., Leal Y., Galasso S., Galderisi A., Vallone V., Di Palma F., Losiouk E., Lanzola G., Tinti T., Rigamonti A., Marigliano M., Zanfardino A., Rapini N., Avogaro A., Chernavvsky D., Magni L., Cobelli C., Bruttomesso D., Del Favero, S., Boscari, F., Messori, M., Rabbone, I., Bonfanti, R., Sabbion, A., Iafusco, D., Schiaffini, R., Visentin, R., Calore, R., Leal, Y., Galasso, S., Galderisi, A., Vallone, V., Di Palma, F., Losiouk, E., Lanzola, G., Tinti, T., Rigamonti, A., Marigliano, M., Zanfardino, A., Rapini, N., Avogaro, A., Chernavvsky, D., Magni, L., Cobelli, C., and Bruttomesso, D.
- Abstract
Background and Aims: The Artificial Pancreas (AP) system based on the Modular Model Predictive Control algorithm (MMPC) running on the wearable platform Diabetes Assistant (DiAs, University of Virginia) has been successfully used for 2 months in adults patients reducing time-in-hypo (CGM
- Published
- 2016
46. The artificial pancreas in children: First tests in Italy
- Author
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Boscari F., Del Favero S., Messori M., Rabbone I., Bonfanti R., Sabbion A., Iafusco D., Schiaffini R., Visentin R., Calore R., Leal Y., Galasso S., Galderisi A., Vallone V., Di Palma F., Losiouk E., Lanzola G., Tinti D., Rigamonti A., Marigliano M., Zanfardino A., Rapini N., Avogaro A., Chernavvsky D., Magni L., Cobelli C., Bruttomesso D., Boscari, F., Del Favero, S., Messori, M., Rabbone, I., Bonfanti, R., Sabbion, A., Iafusco, D., Schiaffini, R., Visentin, R., Calore, R., Leal, Y., Galasso, S., Galderisi, A., Vallone, V., Di Palma, F., Losiouk, E., Lanzola, G., Tinti, D., Rigamonti, A., Marigliano, M., Zanfardino, A., Rapini, N., Avogaro, A., Chernavvsky, D., Magni, L., Cobelli, C., and Bruttomesso, D.
- Subjects
Artificial pancreas ,Hypoglycemia ,Type 1 diabetes mellitus in children - Abstract
Background. The artificial pancreas (AP) system based on the Modular Model Predictive Control algorithm (MMPC) running on the wearable platform Diabetes Assistant (DiAs) has been used in adult outpatients with type 1 diabetes (T1D), reducing the time spent in hypoglycemia and increasing the time spent in the near-normal range of 70-180 mg/dl compared to Sensor Augmented Pump therapy (SAP). Objective. In the PEDiatric ARtificial PANcreas (PedArPan) project we tested a children-specific version of the MMPC on DiAs in 5-9 yearold children during a summer camp. This is the first outpatient AP trial in a population of this age. Study design and methods. Thirty 5-9 year-old children with T1D and their parents were recruited from five Italian pediatric centers and completed an open label, randomized, crossover trial in a summer camp (supervised outpatient setting). Glucose control in three days of AP use was compared with three days of parent-managed SAP. Results. Overnight (00:00-07:30). The AP significantly reduced time-in-hypo compared to SAP, 0% [0.00-2.22] vs. 2.19% [0.00- 12.30], p = 0.002, with no significant difference in time-in-target (70-180 mg/dl), 55.97% (22.53) vs. 59.69% (21.24), p = 0.430, or time-in-tight-target (80-140 mg/dl), 31.27% (20.23) vs. 33.02% (19.80), p = 0.694. Overall (00:00-24:00). There was a threefold reduction of time-in-hypo, 2.02% [1.17-4.54] vs. 6.67% [2.26-11.54], p < 0.001, with AP at the expense of some deterioration of time-in-target, 56.79% (13.47) vs. 63.09% (10.98), p = 0.022. Conclusions. This study showed the feasibility and safety of a wearable MMPC in young children. Next steps will include overnight testing at home and re-tuning the algorithm to boost efficacy during daytime.
- Published
- 2016
47. Il pancreas artificiale in età pediatrica: Prima esperienza Italiana
- Author
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Federico Boscari, Simone Del Favero, Messori, M., Rabbone, I., Bonfanti, R., Sabbion, Alberto, Iafusco, D., Schiaffini, R., Roberto Visentin, Calore, R., Leal Moncada, Yenny Teresa, Galasso, S., Alfonso Galderisi, Vallone, V., Di Palma, F., Eleonora Losiouk, Lanzola, G., Tinti, D., Rigamonti, A., Marigliano, M., Zanfardino, A., Rapini, N., ANGELO AVOGARO, Chernavvsky, Daniel, Magni, L., Claudio Cobelli, Bruttomesso, Daniela, Boscari, F, Del Favero, S., Messori, M., Rabbone, I., Bonfanti, R., Sabbion, A., Iafusco, Dario, Schiaffini, R., Visentin, R., Calore, R., Leal, Y., Galasso, S., Galderisi, A., Vallone, V., Di Palma, F., Losiouk, E., Lanzola, G., Tinti, D., Rigamonti, A., Marigliano, M., Zanfardino, A., Rapini, N., Avogaro, A., Chernavvsky, D., Magni, L., Cobelli, C., and Bruttomesso, Daniela
- Subjects
Diabetes and Metabolism ,Endocrinology ,Endocrinology, Diabetes and Metabolism ,Artificial pancreas ,Hypoglycemia ,Type 1 diabetes mellitus in children ,Internal Medicine ,Artificial pancrea - Abstract
Background. The artificial pancreas (AP) system based on the Modular Model Predictive Control algorithm (MMPC) running on the wearable platform Diabetes Assistant (DiAs) has been used in adult outpatients with type 1 diabetes (T1D), reducing the time spent in hypoglycemia and increasing the time spent in the near-normal range of 70-180 mg/dl compared to Sensor Augmented Pump therapy (SAP). Objective. In the PEDiatric ARtificial PANcreas (PedArPan) project we tested a children-specific version of the MMPC on DiAs in 5-9 yearold children during a summer camp. This is the first outpatient AP trial in a population of this age. Study design and methods. Thirty 5-9 year-old children with T1D and their parents were recruited from five Italian pediatric centers and completed an open label, randomized, crossover trial in a summer camp (supervised outpatient setting). Glucose control in three days of AP use was compared with three days of parent-managed SAP. Results. Overnight (00:00-07:30). The AP significantly reduced time-in-hypo compared to SAP, 0% [0.00-2.22] vs. 2.19% [0.00- 12.30], p = 0.002, with no significant difference in time-in-target (70-180 mg/dl), 55.97% (22.53) vs. 59.69% (21.24), p = 0.430, or time-in-tight-target (80-140 mg/dl), 31.27% (20.23) vs. 33.02% (19.80), p = 0.694. Overall (00:00-24:00). There was a threefold reduction of time-in-hypo, 2.02% [1.17-4.54] vs. 6.67% [2.26-11.54], p < 0.001, with AP at the expense of some deterioration of time-in-target, 56.79% (13.47) vs. 63.09% (10.98), p = 0.022. Conclusions. This study showed the feasibility and safety of a wearable MMPC in young children. Next steps will include overnight testing at home and re-tuning the algorithm to boost efficacy during daytime.
- Published
- 2016
48. Organization and regional distribution of centers for the management of children and adolescents with diabetes in Italy
- Author
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Giorgetti C., Ferrito L., Zallocco F., Iannilli A., Cherubini V., Maghnie M., Rabbone I., Lera R., De Luna L., Kienberger B., Gualtieri A., Zecchino C., Piccino E., Ortolani F., Zucchini S., Maltoni G., Pasquino B., Reinstadler P., Prandi E., Zattoni V., Gallo F., Morganti G., Guerraggio L., Ripoli C., Frongia M., Pusceddu P., La Loggia A., Scanu P., Cardinale G., Ponzi G., Tomaselli L. G., Rapisarda V., Citriniti F., Soprani T., Tumini S., Lazzaro N., De Donno V., Banin P., Toni S., Lenzi L., Mainetti B., Coccioli M. S., D'Annunzio G., Minuto N., Montani E., Maccioni R., Marongiu U., Beccaria L., Bruzzese M., Mammi F., Pardi D., Lombardo F., Ventrici C., Scaramazza A., Ferrari M., Bonfanti R., Rigamonti A., Iughetti L., Predieri B., Iafusco D., Confetto S., Zanfardino A., Prisco F., Francese A., De Nitto E., Cadario F., Milia A., Piredda G., Mereu L., Soro M., Correddu A., Pipia A., Monciotti C., Cardella F., De Berardinis F., Santoro G., Chiari G., Berioli M. G., Federico G., Zanette G., Marsciani A., Pedini A., Patera I. P., Schiaffini R., Bitti M., Lidano R., Pietrosanti S., Delvecchio M., Trada M., Marinaro A., Meloni G., Galero A., Fichera G., Bulciolu P., Ignaccolo G., Cauvin V., Franceschi R., Faleschini E., Tornese G., Salvatoni A., Cardani R., Maffeis C., Marigliano M., Sabbion A., Arnaldi C., Giorgetti, Chiara, Ferrito, Lucia, Zallocco, Federica, Iannilli, Antonio, Cherubini, Valentino, Maghnie, Mohamad, Rabbone, Ivana, Lera, R., De Luna, L., Kienberger, B., Gualtieri, A., Zecchino, C., Piccino, E., Ortolani, F., Zucchini, S., Maltoni, G., Pasquino, B., Reinstadler, P., Prandi, E., Zattoni, V., Gallo, F., Morganti, G., Guerraggio, L., Ripoli, C., Frongia, M., Pusceddu, P., La Loggia, A., Scanu, P., Cardinale, G., Ponzi, G., Tomaselli, L. G., Rapisarda, V., Citriniti, F., Soprani, T., Tumini, S., Lazzaro, N., De Donno, V., Banin, P., Toni, S., Lenzi, L., Mainetti, B., Coccioli, M. S., D’Annunzio, G., Minuto, N., Montani, E., Maccioni, R., Marongiu, U., Beccaria, L., Bruzzese, M., Mammì, F., Pardi, D., Lombardo, F., Ventrici, C., Scaramazza, A., Ferrari, M., Bonfanti, R., Rigamonti, A., Iughetti, L., Predieri, B., Iafusco, Dario, Confetto, S., Zanfardino, A., Prisco, Francesco, Francese, A., De Nitto, E., Cadario, F., Milia, A., Piredda, G., Mereu, L., Soro, M., Correddu, A., Pipia, A., Monciotti, C., Cardella, F., De Berardinis, F., Santoro, G., Chiari, G., Berioli, M. G., Federico, G., Zanette, G., Marsciani, A., Pedini, A., Patera, I. P., Schiaffini, R., Bitti, M., Lidano, R., Pietrosanti, S., Delvecchio, M., Trada, M., Marinaro, A., Meloni, G., Galero, A., Fichera, G., Bulciolu, P., Rabbone, I., Ignaccolo, G., Cauvin, V., Franceschi, R., Faleschini, E., Tornese, G., Salvatoni, A., Cardani, R., Maffeis, C., Marigliano, M., Sabbion, A., Arnaldi, C., Study Group for Diabetes of, Isped, Tornese, Gianluca, Giorgetti, C., Ferrito, L., Zallocco, F., Iannilli, A., Cherubini, V., Maghnie, M., D'Annunzio, G., Mammi, F., Iafusco, D., and Prisco, F.
- Subjects
Male ,medicine.medical_specialty ,Type 1 diabete ,Adolescent ,MEDLINE ,Staffing ,Distribution (economics) ,Legislation ,diabetes ,children ,T1D ,Italy ,Pediatrics ,Regional Medical Program ,Prevalence ,Surveys and Questionnaire ,Medicine ,Regional legislation ,Practice Patterns, Physicians' ,Disease management (health) ,Child ,Organization of care ,Pediatric diabetes centers ,Type 1 diabetes ,Pediatrics, Perinatology and Child Health ,business.industry ,Incidence ,Incidence (epidemiology) ,Research ,Disease Management ,Perinatology and Child Health ,medicine.disease ,Diabetes Mellitus, Type 1 ,diabete ,Family medicine ,Female ,Organizational structure ,Pediatric diabetes center ,business ,Delivery of Health Care ,Human - Abstract
Background: The incidence of type 1 diabetes in childhood is increasing by 3 % per year, placing growing demands on healthcare professionals and medical expenditures. Aim of this study wars to assess the organization of care to children with diabetes in Italy. Methods: During 2012 a structured questionnaire was sent to all of the members of Italian Society of Paediatric Endocrinology and Diabetology (ISPED). Questions examined organizational structure of Centers, personnel dedicated to the care of children with diabetes, number of subjects followed, local legal legislation supporting centres. Results: A total of 68 centers taking care to 15,563 children and adolescents with diabetes under 18 years of age were identified with a prevalence of 1.4 per 1,000 people. A wide variation in the organizational background was also reported. Fourty-four centers were organized as outpatient departments, 17 as simple units, 5 as complex units and 2 as simple departmental structures. Most centers had a multidisciplinary team. Ten out of twenty Italian regions had introduced supportive regional legislation, but it was fully applied only in six of them. Conclusion: Great differences between regions were found in organizational structures, staffing levels and supportive legislation. The national legislation on diabetes was broadly implemented throughout the country regions. Further efforts are needed to improve standards and consistency of pediatric diabetes care in Italy.
- Published
- 2015
49. Closing the Loop
- Author
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Revital, Nimri, Nathan, Murray, Alexander, Ochs, Jordan, E Pinsker, Eyal, Dassau, Pinsker, Je, Lee, Jb, Dassau, E, Seborg, De, Bradley, Pk, Gondhalekar, R, Bevier, Wc, Huyett, L, Zisser, Hc, FJ Doyle III, DEL FAVERO, Simone, Boscari, F, Messori, M, Rabbone, I, Bonfanti, R, Sabbion, A, Iafusco, D, Schiaffini, R, Visentin, R, Calore, R, Moncada, Yl, Galasso, S, Galderisi, A, Vallone, V, DI PALMA, Federico, Losiouk, E, Lanzola, G, Tinti, D, Rigamonti, A, Marigliano, M, Zanfardino, A, Rapini, N, Avogaro, A, Chernavvsky, D, Magni, L, Cobelli, C, Bruttomesso, D, Sherr, Jl, Patel, Ns, Michaud, Ci, Palau-Collazo, Mm, MA Van Name, Tamborlane, Wv, Cengiz, E, Carria, Lr, Tichy, Em, Weinzimer, Sa, Renard, E, Farret, A, Kropff, J, Place, J, Toffanin, C, Magni, P, Keith-Hynes, P, Kovatchev, B, Devries, Jh, AP@ home Consortium, Gingras, V, Haidar, A, Messier, V, Legault, L, Ladouceur, M, Rabasa-Lhoret, R, Tt, Ly, Maahs, Dm, Roy, A, Grosman, B, Cantwell, M, Kurtz, N, Carria, L, Messer, L, R von Eyben, Buckingham, Ba, Ruan, Y, Thabit, H, Leelarathna, L, Hartnell, S, Willinska, Me, Dellweg, S, Benesch, C, Mader, Jk, Holzer, M, Kojzar, H, Evans, Ml, Pieber, Tr, Arnolds, S, Hovorka, R, Tauschmann, M, Allen, Jm, Wilinska, Me, Stewart, Z, Cheng, P, Kollman, C, Acerini, Cl, Dunger, Db, Monaro, M, Kovatchev, Bp, AP@ home consortium1, and Heinemann, L
- Published
- 2017
50. Analysis of a cohort of pediatric patients treated with continuous subcutaneous insulin infusion
- Author
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Rubino C., Rigamonti A., Frontino G., Battaglino R., Favalli V., Bonura C., Barera G., Meschi F., Bonfanti R., Rubino, C., Rigamonti, A., Frontino, G., Battaglino, R., Favalli, V., Bonura, C., Barera, G., Meschi, F., and Bonfanti, R.
- Subjects
Type 1 diabetes ,Insulin pump ,Children - Abstract
We analyzed a cohort of pediatric patients with type 1 diabetes mellitus treated with continuous insulin infusion (CSII), followed at the San Raffaele Hospital (Milan, Italy) in the period 2007-2014. We collected data from a questionnaire and from outpatient charts for 206 patients, whose average age was 12.93 years; 93.2% followed our protocol for starting CSII. The drop-out rate was 3.4%. Mean HbA1c was comparable to that of patients on multiple daily injections (MDI) and long-term analysis did not show any significant changes before and after CSII. The incidence of acute complications was low: 1.42 episodes/100 patients/year for severe hypoglycemia (about 50% fewer than in those using MDI), 1.11 episodes/100 patients/year for diabetic ketoacidosis. CSII patients did not gain weight and we found a significant relation between follow-up BMI and HbA1c. There was also a correlation between the use of a vertical cannula and HbA1c reduction. Most of these patients used advanced functions (bolus calculator, temporary basal rates), telemedicine and carbohydrate counting, but only carbohydrate counting was related to the improvement in HbA1c: 60.2% used continuous glucose monitoring (CGM) but here too there was no relation with reduced HbA1c; 53.4% replaced the pump at least once and 41.7% reported malfunctions (no adverse events). The distribution of insulin basal rates differed between age groups 0-6, 7-12, and 13-18 years; this confirms other reports and the advantage of CSII over MDI in children under the age of six. The average number of bolus injections was lower than expected and was not significantly related with HbA1c. CSII is safe and effective. Most studies report no significant improvement in HbA1c, but there is a lower incidence of acute complications. CSII therapy is a mandatory step towards the application of new diabetes technology (artificial pancreas) but further studies need to assess long-term cost and benefits.
- Published
- 2015
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