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12 results on '"Bonfantini, Francesca"'

7. Hypofractionated whole-breast radiotherapy in large breast size patients: is it really a resolved issue?

Author

Colciago, R, Cavallo, A, Magri, M, Vitullo, A, La Rocca, E, Giandini, C, Bonfantini, F, Di Cosimo, S, Baili, P, Sant, M, Pignoli, E, Valdagni, R, Lozza, L, De Santis, M, Colciago, Riccardo Ray, Cavallo, Anna, Magri, Maria Chiara, Vitullo, Angelo, La Rocca, Eliana, Giandini, Carlotta, Bonfantini, Francesca, Di Cosimo, Serena, Baili, Paolo, Sant, Milena, Pignoli, Emanuele, Valdagni, Riccardo, Lozza, Laura, De Santis, Maria Carmen, Colciago, R, Cavallo, A, Magri, M, Vitullo, A, La Rocca, E, Giandini, C, Bonfantini, F, Di Cosimo, S, Baili, P, Sant, M, Pignoli, E, Valdagni, R, Lozza, L, De Santis, M, Colciago, Riccardo Ray, Cavallo, Anna, Magri, Maria Chiara, Vitullo, Angelo, La Rocca, Eliana, Giandini, Carlotta, Bonfantini, Francesca, Di Cosimo, Serena, Baili, Paolo, Sant, Milena, Pignoli, Emanuele, Valdagni, Riccardo, Lozza, Laura, and De Santis, Maria Carmen

Abstract

The purpose of this study was to evaluate the impact of breast size on acute and late side effects in breast cancer (BC) patients treated with hypofractionated radiotherapy (Hypo-RT). In this study we analyzed patients over 50 years with a diagnosis of early BC, candidate for Hypo-RT after conservative surgery. Acute and late skin toxicities were evaluated in accordance with the RTOG scale. Multivariable logistic analysis was performed using dosimetric/anatomical factors resulted associated with toxicity outcome in univariable analysis. Among patients treated between 2009 and 2015, 425 had at least 5 years of follow-up. At RT end, acute skin toxicity ≥ G2 and edema ≥ G2 occurred in 88 (20.7%) and 4 (0.9%) patients, respectively. The multivariable analysis showed association of skin toxicity with boost administration (p < 0.01), treated skin area (TSA) receiving more than 20 Gy (p = 0.027) and breast volume receiving 105% of the prescription dose (V105%) (p = 0.016), but not breast size. At 5 years after RT, fibrosis ≥ G1 occurred in 89 (20.9%) patients and edema ≥ G1 in 36 (8.5%) patients. Fibrosis resulted associated with breast volume ≥ 1000 cm3 (p = 0.04) and hypertension (p = 0.04). As for edema, multivariable logistic analysis showed a correlation with hypertension and logarithm of age, but not with boost administration. Breast volume had an unclear impact (p = 0.055). A recurrent association was found between acute and late toxicities and breast V105%, which is correlated with breast size. This may suggest that a more homogenous RT technique may be preferred for patients with larger breast size.

Published
2021

8. Hypofractionated irradiation in 794 elderly breast cancer patients: An observational study

Author

La Rocca, Eliana, primary, Meneghini, Elisabetta, additional, Dispinzieri, Michela, additional, Fiorentino, Alba, additional, Bonfantini, Francesca, additional, Di Cosimo, Serena, additional, Gennaro, Massimiliano, additional, Cosentino, Vito, additional, Sant, Milena, additional, Pignoli, Emanuele, additional, Valdagni, Riccardo, additional, Lozza, Laura, additional, and De Santis, Maria Carmen, additional

Published
2019
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10. Interobserver variability (between radiation oncologist and radiation therapist) in tumor bed contouring after breast-conserving surgery

Author

La Rocca, Eliana, primary, Lici, Vanessa, additional, Giandini, Tommaso, additional, Bonfantini, Francesca, additional, Frasca, Sarah, additional, Dispinzieri, Michela, additional, Gennaro, Massimiliano, additional, Di Cosimo, Serena, additional, Lozza, Laura, additional, Pignoli, Emanuele, additional, Valdagni, Riccardo, additional, and De Santis, Maria Carmen, additional

Published
2019
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11. Hypofractionated irradiation in 794 elderly breast cancer patients: An observational study.

Author

La Rocca, Eliana, Meneghini, Elisabetta, Dispinzieri, Michela, Fiorentino, Alba, Bonfantini, Francesca, Di Cosimo, Serena, Gennaro, Massimiliano, Cosentino, Vito, Sant, Milena, Pignoli, Emanuele, Valdagni, Riccardo, Lozza, Laura, and De Santis, Maria Carmen

Subjects
AGE distribution, BREAST tumors, CONFIDENCE intervals, DEATH, SCIENTIFIC observation, PATIENT safety, RADIATION doses, RISK assessment, COMORBIDITY, TREATMENT effectiveness, DISEASE progression, DESCRIPTIVE statistics, ODDS ratio, OLD age
Abstract

To assess the efficacy, and the acute and late toxicity of hypofractionated radiotherapy (Hypo‐RT), and the impact of age and comorbidities on disease progression and death in elderly breast cancer (BC) patients. Women aged ≥65 years who received Hypo‐RT (42.4 Gy in 16 fractions, plus a boost for high‐risk patients) were considered for the present analysis. Competing risk analysis was used to estimate the 5‐year cumulative incidence of BC progression and BC‐related death, calculating the adjusted subhazard ratios (SHR) with 95% confidence intervals (95%CI) in relation to age, hypertension‐augmented Charlson Comorbidity Index (hCCI), tumor characteristics, and chemotherapy. The sample included 794 patients with a median age of 74 years (range 65‐91 years). At the baseline, 70% of these patients had at least one comorbidity. With a median follow‐up of 48.3 months, the 5‐year cumulative incidence of BC progression and BC‐related death was 6.7% (95%CI 4.8%‐9.2%) and 2.3% (95%CI 1.2%‐3.9%), respectively. Old age (≥80 years) and a high burden of comorbidity (hCCI ≥ 2) were independently associated with BC progression. Hypo‐RT is safe in elderly BC patients, but age and comorbidities influence BC progression. Further studies are warranted. [ABSTRACT FROM AUTHOR]

Published
2020
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12. Axillary Coverage by Whole Breast Irradiation in 1 to 2 Positive Sentinel Lymph Nodes in Breast Cancer Patients

Author

De Santis, Maria Carmen, primary, Bonfantini, Francesca, additional, Dispinzieri, Michela, additional, Meroni, Silvia, additional, Diletto, Barbara, additional, Mantero, Elisa D., additional, Franceschini, Marzia, additional, Soncini, Fulvia, additional, Di Cosimo, Serena, additional, Cosentino, Vito, additional, Pignoli, Emanuele, additional, and Lozza, Laura, additional

Published
2016
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