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1. An increase in CD62L dim neutrophils precedes the development of pulmonary embolisms in COVID‐19 patients

Author

Spijkerman, Roy, Jorritsma, Nikita K. N., Bongers, Suzanne H., Bindels, Bas J. J., Jukema, Bernard N., Hesselink, Lillian, Hietbrink, Falco, Leenen, Luke P. H., Goor, Harriët M. R., Vrisekoop, Nienke, Kaasjager, Karin A. H., Koenderman, Leo, Stiphout, Feike, Nijdam, Thomas M. P., van de Ven, Nils L. M., Verhaegh, Remi, Spanjaard, Judith S., Verboeket, Benjamin W., Laane, Duco, van Wessem, Karlijn, van spengler, Daan E. J., Buitenwerf, Wiebe, Giustarini, Giulio, Mulder, Eva, Heijerman, Harry, Zabaleta, Amely Daza, van den bos, Frederique, Rademaker, Emma, Varkila, Meri R. J., de Mul, Nikki, Cremer, Olaf L., Slooter, Arjen, Delemarre, Eveline M., Nierkens, Stefan, Limper, Maarten, van Wijk, Femke, Pandit, Aridaman, Leavis, Helen, Clark, Chantal C., Barendrecht, Arjan D., Seinen, Cor W., Drost‐Verhoef, Sandra, Smits, Simone, Parr, Naomi M. J., Sebastian, Sylvie A. E., Koekman, Arnold C., van Wesel, Annet C., van der Vries, Erhard, Maas, Coen, de Maat, Steven, Haitjema, Saskia, and Hoefer, Imo E.

Subjects
Male, 0301 basic medicine, pulmonary embolism, Neutrophils, Receptor expression, SARS‐CoV‐2, Neutrophil Activation, law.invention, Cohort Studies, 0302 clinical medicine, Immunophenotyping, law, L‐selectin, L-Selectin, biology, Incidence (epidemiology), Regular Article, General Medicine, Middle Aged, Prognosis, Thrombosis, Intensive care unit, Pulmonary embolism, Intensive Care Units, Female, L-selectin, Disease Susceptibility, medicine.medical_specialty, Intensive Care Unit, Immunology, CD16, 03 medical and health sciences, COVID‐19, Internal medicine, medicine, CD62L, Humans, Aged, SARS-CoV-2, business.industry, COVID-19, medicine.disease, 030104 developmental biology, biology.protein, business, Biomarkers, Regular Articles, 030215 immunology
Abstract

Objectives A high incidence of pulmonary embolism (PE) is reported in patients with critical coronavirus disease 2019 (COVID‐19). Neutrophils may contribute to this through a process referred to as immunothrombosis. The aim of this study was to investigate the occurrence of neutrophil subpopulations in blood preceding the development of COVID‐19 associated PE. Methods We studied COVID‐19 patients admitted to the ICU of our tertiary hospital between 19‐03‐2020 and 17‐05‐2020. Point‐of‐care fully automated flow cytometry was performed prior to ICU admission, measuring the neutrophil activation/maturation markers CD10, CD11b, CD16 and CD62L. Neutrophil receptor expression was compared between patients who did or did not develop PE (as diagnosed on CT angiography) during or after their ICU stay. Results Among 25 eligible ICU patients, 22 subjects were included for analysis, of whom nine developed PE. The median (IQR) time between neutrophil phenotyping and PE occurrence was 9 (7‐12) days. A significant increase in the immune‐suppressive neutrophil phenotype CD16bright/CD62Ldim was observed on the day of ICU admission (P = 0.014) in patients developing PE compared to patients who did not. Conclusion The increase in this neutrophil phenotype indicates that the increased number of CD16bright/CD62Ldim neutrophils might be used as prognostic marker to predict those patients that will develop PE in critical COVID‐19 patients.

Published
2021
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2. Kinetics of Neutrophil Subsets in Acute, Subacute, and Chronic Inflammation

Author

Bongers, Suzanne H., Chen, Na, Grinsven, E. van, Staveren, S. van, Hassani, M., Spijkerman, Roy, Leijte, G.P., Kox, M., Pickkers, P., Koenderman, L., Vrisekoop, Nienke, Bongers, Suzanne H., Chen, Na, Grinsven, E. van, Staveren, S. van, Hassani, M., Spijkerman, Roy, Leijte, G.P., Kox, M., Pickkers, P., Koenderman, L., and Vrisekoop, Nienke

Abstract

Contains fulltext : 235162.pdf (Publisher’s version ) (Open Access)

Published
2021

3. Kinetics of Neutrophil Subsets in Acute, Subacute, and Chronic Inflammation

Author

Infection & Immunity, Experimentele Afdeling Longziekten, Onderzoek Longziekten, Zorgeenheid Traumatologie, Longziekten, Bongers, Suzanne H., Chen, Na, van Grinsven, Erinke, van Staveren, Selma, Hassani, Marwan, Spijkerman, Roy, Hesselink, Lilian, Lo Tam Loi, Adèle T., van Aalst, Corneli, Leijte, Guus P., Kox, Matthijs, Pickkers, Peter, Hietbrink, Falco, Leenen, Luke P.H., Koenderman, Leo, Vrisekoop, Nienke, Infection & Immunity, Experimentele Afdeling Longziekten, Onderzoek Longziekten, Zorgeenheid Traumatologie, Longziekten, Bongers, Suzanne H., Chen, Na, van Grinsven, Erinke, van Staveren, Selma, Hassani, Marwan, Spijkerman, Roy, Hesselink, Lilian, Lo Tam Loi, Adèle T., van Aalst, Corneli, Leijte, Guus P., Kox, Matthijs, Pickkers, Peter, Hietbrink, Falco, Leenen, Luke P.H., Koenderman, Leo, and Vrisekoop, Nienke

Published
2021

4. The Systemic Immune Response in COVID-19 Is Associated with a Shift to Formyl-Peptide Unresponsive Eosinophils

Author

Experimentele Afdeling Longziekten, Infection & Immunity, Cancer, Orthopaedie Opleiding, Acute geneeskunde, MS Interne Geneeskunde, Circulatory Health, Koenderman, Leo, Siemers, Maarten J, van Aalst, Corneli, Bongers, Suzanne H, Spijkerman, Roy, Bindels, Bas J J, Giustarini, Giulio, van Goor, Harriët M R, Kaasjager, Karin A H, Vrisekoop, Nienke, Experimentele Afdeling Longziekten, Infection & Immunity, Cancer, Orthopaedie Opleiding, Acute geneeskunde, MS Interne Geneeskunde, Circulatory Health, Koenderman, Leo, Siemers, Maarten J, van Aalst, Corneli, Bongers, Suzanne H, Spijkerman, Roy, Bindels, Bas J J, Giustarini, Giulio, van Goor, Harriët M R, Kaasjager, Karin A H, and Vrisekoop, Nienke

Published
2021

5. Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation: A normal response to an abnormal situation

Author

Experimentele Afdeling Longziekten, Zorgeenheid Traumatologie, MS Orthopaedie Algemeen, Infection & Immunity, CTI UDAIR, CDL Patiëntenzorg MI, CTI Research, Cancer, Acute geneeskunde, MS Interne Geneeskunde, Circulatory Health, Longziekten, Unit Opleiding Aios, MS Geriatrie, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, DVF Medisch, Brain, MS Reumatologie/Immunologie/Infectie, CTI Van Wijk, Child Health, CTI Pandit, Lab Reumatologie/Klinische Immunologie, CDL Contact activatie, CDL Research analisten, Centraal Diagnostisch Laboratorium, CDL Staf Research, CDL Arcadia, Spijkerman, Roy, Bongers, Suzanne H., Bindels, Bas J.J., Tinnevelt, Gerjen H., Giustarini, Giulio, Jorritsma, Nikita K.N., Buitenwerf, Wiebe, van Spengler, Daan E.J., Delemarre, Eveline M., Nierkens, Stefan, van Goor, Harriët M.R., Jansen, Jeroen J., Vrisekoop, Nienke, Hietbrink, Falco, Leenen, Luke P.H., Kaasjager, Karin A.H., Koenderman, Leo, the COVPACH study group, Experimentele Afdeling Longziekten, Zorgeenheid Traumatologie, MS Orthopaedie Algemeen, Infection & Immunity, CTI UDAIR, CDL Patiëntenzorg MI, CTI Research, Cancer, Acute geneeskunde, MS Interne Geneeskunde, Circulatory Health, Longziekten, Unit Opleiding Aios, MS Geriatrie, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, DVF Medisch, Brain, MS Reumatologie/Immunologie/Infectie, CTI Van Wijk, Child Health, CTI Pandit, Lab Reumatologie/Klinische Immunologie, CDL Contact activatie, CDL Research analisten, Centraal Diagnostisch Laboratorium, CDL Staf Research, CDL Arcadia, Spijkerman, Roy, Bongers, Suzanne H., Bindels, Bas J.J., Tinnevelt, Gerjen H., Giustarini, Giulio, Jorritsma, Nikita K.N., Buitenwerf, Wiebe, van Spengler, Daan E.J., Delemarre, Eveline M., Nierkens, Stefan, van Goor, Harriët M.R., Jansen, Jeroen J., Vrisekoop, Nienke, Hietbrink, Falco, Leenen, Luke P.H., Kaasjager, Karin A.H., Koenderman, Leo, and the COVPACH study group

Published
2021

6. An increase in CD62Ldim neutrophils precedes the development of pulmonary embolisms in COVID-19 patients

Author

Experimentele Afdeling Longziekten, Cancer, Trialbureau Beeld, Zorgeenheid Traumatologie, MS Orthopaedie Algemeen, Infection & Immunity, Acute geneeskunde, MS Interne Geneeskunde, Circulatory Health, Medische Staf Intensive Care, Spijkerman, Roy, Jorritsma, Nikita Kn, Bongers, Suzanne H, Bindels, Bas Jj, Jukema, Bernard N, Hesselink, Lillian, Hietbrink, Falco, Leenen, Luke Ph, van Goor, Harriët Mr, Vrisekoop, N, Kaasjager, Karin Ah, Koenderman, Leo, COVPACH study group, Experimentele Afdeling Longziekten, Cancer, Trialbureau Beeld, Zorgeenheid Traumatologie, MS Orthopaedie Algemeen, Infection & Immunity, Acute geneeskunde, MS Interne Geneeskunde, Circulatory Health, Medische Staf Intensive Care, Spijkerman, Roy, Jorritsma, Nikita Kn, Bongers, Suzanne H, Bindels, Bas Jj, Jukema, Bernard N, Hesselink, Lillian, Hietbrink, Falco, Leenen, Luke Ph, van Goor, Harriët Mr, Vrisekoop, N, Kaasjager, Karin Ah, Koenderman, Leo, and COVPACH study group

Published
2021

7. Kinetics of Neutrophil Subsets in Acute, Subacute, and Chronic Inflammation

Author

Bongers, Suzanne H., primary, Chen, Na, additional, van Grinsven, Erinke, additional, van Staveren, Selma, additional, Hassani, Marwan, additional, Spijkerman, Roy, additional, Hesselink, Lilian, additional, Lo Tam Loi, Adèle T., additional, van Aalst, Corneli, additional, Leijte, Guus P., additional, Kox, Matthijs, additional, Pickkers, Peter, additional, Hietbrink, Falco, additional, Leenen, Luke P. H., additional, Koenderman, Leo, additional, and Vrisekoop, Nienke, additional

Published
2021
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9. Thrombotic Events in COVID-19 Are Associated With a Lower Use of Prophylactic Anticoagulation Before Hospitalization and Followed by Decreases in Platelet Reactivity

Author

Clark, Chantal C., primary, Jukema, Bernard N., additional, Barendrecht, Arjan D., additional, Spanjaard, Judith S., additional, Jorritsma, Nikita K. N., additional, Smits, Simone, additional, de Maat, Steven, additional, Seinen, Cor W., additional, Verhoef, Sandra, additional, Parr, Naomi M. J., additional, Sebastian, Silvie A. E., additional, Koekman, Arnold C., additional, van Wesel, Annet C. W., additional, van Goor, Harriet M. R., additional, Spijkerman, Roy, additional, Bongers, Suzanne H., additional, van der Vries, Erhard, additional, Nierkens, Stefan, additional, Boes, Marianne, additional, Koenderman, Leo, additional, Kaasjager, Karin A. H., additional, and Maas, Coen, additional

Published
2021
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10. An increase in CD62Ldim neutrophils precedes the development of pulmonary embolisms in COVID‐19 patients.

Author

Spijkerman, Roy, Jorritsma, Nikita K. N., Bongers, Suzanne H., Bindels, Bas J. J., Jukema, Bernard N., Hesselink, Lillian, Hietbrink, Falco, Leenen, Luke P. H., Goor, Harriët M. R., Vrisekoop, Nienke, Kaasjager, Karin A. H., Koenderman, Leo, Stiphout, Feike, Nijdam, Thomas M. P., van de Ven, Nils L. M., Verhaegh, Remi, Spanjaard, Judith S., Verboeket, Benjamin W., Laane, Duco, and van Wessem, Karlijn

Subjects
COVID-19, PULMONARY embolism, NEUTROPHILS
Abstract

Objectives: A high incidence of pulmonary embolism (PE) is reported in patients with critical coronavirus disease 2019 (COVID‐19). Neutrophils may contribute to this through a process referred to as immunothrombosis. The aim of this study was to investigate the occurrence of neutrophil subpopulations in blood preceding the development of COVID‐19 associated PE. Methods: We studied COVID‐19 patients admitted to the ICU of our tertiary hospital between 19‐03‐2020 and 17‐05‐2020. Point‐of‐care fully automated flow cytometry was performed prior to ICU admission, measuring the neutrophil activation/maturation markers CD10, CD11b, CD16 and CD62L. Neutrophil receptor expression was compared between patients who did or did not develop PE (as diagnosed on CT angiography) during or after their ICU stay. Results: Among 25 eligible ICU patients, 22 subjects were included for analysis, of whom nine developed PE. The median (IQR) time between neutrophil phenotyping and PE occurrence was 9 (7‐12) days. A significant increase in the immune‐suppressive neutrophil phenotype CD16bright/CD62Ldim was observed on the day of ICU admission (P = 0.014) in patients developing PE compared to patients who did not. Conclusion: The increase in this neutrophil phenotype indicates that the increased number of CD16bright/CD62Ldim neutrophils might be used as prognostic marker to predict those patients that will develop PE in critical COVID‐19 patients. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
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11. Flow cytometric evaluation of the neutrophil compartment in COVID‐19 at hospital presentation: A normal response to an abnormal situation.

Author

Spijkerman, Roy, Bongers, Suzanne H., Bindels, Bas J. J., Tinnevelt, Gerjen H., Giustarini, Giulio, Jorritsma, Nikita K. N., Buitenwerf, Wiebe, Spengler, Daan E. J., Delemarre, Eveline M., Nierkens, Stefan, Goor, Harriët M. R., Jansen, Jeroen J., Vrisekoop, Nienke, Hietbrink, Falco, Leenen, Luke P. H., Kaasjager, Karin A. H., and Koenderman, Leo

Subjects
COVID-19, ADULT respiratory distress syndrome, PANDEMICS, SARS-CoV-2, FLOW cytometry, NEUTROPHILS
Abstract

Coronavirus disease 2019 (COVID‐19) is a rapidly emerging pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Critical COVID‐19 is thought to be associated with a hyper‐inflammatory process that can develop into acute respiratory distress syndrome, a critical disease normally mediated by dysfunctional neutrophils. This study tested the hypothesis whether the neutrophil compartment displays characteristics of hyperinflammation in COVID‐19 patients. Therefore, a prospective study was performed on all patients with suspected COVID‐19 presenting at the emergency room of a large academic hospital. Blood drawn within 2 d after hospital presentation was analyzed by point‐of‐care automated flow cytometry and compared with blood samples collected at later time points. COVID‐19 patients did not exhibit neutrophilia or eosinopenia. Unexpectedly neutrophil activation markers (CD11b, CD16, CD10, and CD62L) did not differ between COVID‐19‐positive patients and COVID‐19‐negative patients diagnosed with other bacterial/viral infections, or between COVID‐19 severity groups. In all patients, a decrease was found in the neutrophil maturation markers indicating an inflammation‐induced left shift of the neutrophil compartment. In COVID‐19 this was associated with disease severity. [ABSTRACT FROM AUTHOR]

Published
2021
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